|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
1-236 |
1.76e-131 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 371.05 E-value: 1.76e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALAR 80
Cdd:PRK00481 9 ILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAK--PNAAHRALAE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 81 LERlLPGRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEE-LCSCCQFphPLRPHVVWFGEMP 159
Cdd:PRK00481 87 LEK-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPpRCPKCGG--ILRPDVVLFGEML 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2427736851 160 --LGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFVDELLQ 236
Cdd:PRK00481 164 peLAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEELLA 242
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-232 |
2.54e-117 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 335.21 E-value: 2.54e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALAR 80
Cdd:COG0846 10 LLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAE--PNAAHRALAE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 81 LERLLPgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEE-----LCSCCQfpHPLRPHVVWF 155
Cdd:COG0846 88 LEKAGK-LVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEgelppRCPKCG--GLLRPDVVWF 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2427736851 156 GEM--PLGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFVD 232
Cdd:COG0846 165 GEMlpEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
6-231 |
7.04e-115 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 328.40 E-value: 7.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALARLERLL 85
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQ--PNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 86 PgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEELCSCCQFPHPLRPHVVWFGEM-PLGLDR 164
Cdd:cd01412 79 P-NVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNEEIPEEELPRCPKCGGLLRPGVVWFGESlPLALLE 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2427736851 165 IYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFV 231
Cdd:cd01412 158 AVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
13-186 |
8.69e-69 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 209.80 E-value: 8.69e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 13 GAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQ---RFYNARRHQLqRAEIHPNPAHYALARLERLLPgRV 89
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWdpePFYNIARELL-PGEAQPNPAHYFIAKLEDKGK-LL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 90 TLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEW---RGDLHQEELCSCCQFPHPLRPHVVWFGEM-PLGLDRI 165
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
gi 2427736851 166 YSALAQCNLFISIGTSGAVYP 186
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
1-236 |
1.76e-131 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 371.05 E-value: 1.76e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALAR 80
Cdd:PRK00481 9 ILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAK--PNAAHRALAE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 81 LERlLPGRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEE-LCSCCQFphPLRPHVVWFGEMP 159
Cdd:PRK00481 87 LEK-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPpRCPKCGG--ILRPDVVLFGEML 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2427736851 160 --LGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFVDELLQ 236
Cdd:PRK00481 164 peLAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEELLA 242
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-232 |
2.54e-117 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 335.21 E-value: 2.54e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALAR 80
Cdd:COG0846 10 LLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAE--PNAAHRALAE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 81 LERLLPgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEE-----LCSCCQfpHPLRPHVVWF 155
Cdd:COG0846 88 LEKAGK-LVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEgelppRCPKCG--GLLRPDVVWF 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2427736851 156 GEM--PLGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFVD 232
Cdd:COG0846 165 GEMlpEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
6-231 |
7.04e-115 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 328.40 E-value: 7.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALARLERLL 85
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQ--PNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 86 PgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEELCSCCQFPHPLRPHVVWFGEM-PLGLDR 164
Cdd:cd01412 79 P-NVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNEEIPEEELPRCPKCGGLLRPGVVWFGESlPLALLE 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2427736851 165 IYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFV 231
Cdd:cd01412 158 AVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
5-236 |
2.54e-109 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 315.22 E-value: 2.54e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 5 AKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEIHPNPAHYALARLER- 83
Cdd:PTZ00408 4 CRCITILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLSSSVKPNKAHFALAKLERe 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 84 LLPGRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDL-HQEELCSCCQFPHPLRPHVVWFGEMPLGL 162
Cdd:PTZ00408 84 YRGGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVvHGSSRCKCCGCVGTLRPHIVWFGEMPLYM 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2427736851 163 DRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGPASLLVPAFVDELLQ 236
Cdd:PTZ00408 164 DEIESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGTNYSQFDESIYGKASVIVPAWVDRVLK 237
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
6-222 |
5.83e-89 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 262.51 E-value: 5.83e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVA-TPEGYARDPELVQRFYNARRHQLQraeIHPNPAHYALARLERL 84
Cdd:cd01407 1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPEELAfSPEAFRRDPELFWGFYRERRYPLN---AQPNPAHRALAELERK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 85 LPgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLHQEE-----LCSCCQFPhpLRPHVVWFGEM- 158
Cdd:cd01407 78 GK-LKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDreevpRCPKCGGL--LRPDVVFFGESl 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2427736851 159 PLGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEKRYGP 222
Cdd:cd01407 155 PEELDEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
6-222 |
5.80e-79 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 237.24 E-value: 5.80e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFR-ACDGLWEEHRVEDVA-TPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALARLER 83
Cdd:cd00296 1 KRVVVFTGAGISTESGIPDFRgLGTGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTPLDAK--PNPAHRALAELER 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 84 LLPgRVTLVTQNIDNLHESAGSK--NLIHMHGELLKARCPGSGQVIEWRGDLHQEELCSCCQFPHPLRPHVVWFGEMPL- 160
Cdd:cd00296 79 KGK-LKRIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPDVVDFGEALPk 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2427736851 161 -GLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSE--VGSQFDEKRYGP 222
Cdd:cd00296 158 eWFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREPTPadALKKADLVILGD 222
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
13-186 |
8.69e-69 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 209.80 E-value: 8.69e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 13 GAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQ---RFYNARRHQLqRAEIHPNPAHYALARLERLLPgRV 89
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWdpePFYNIARELL-PGEAQPNPAHYFIAKLEDKGK-LL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 90 TLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEW---RGDLHQEELCSCCQFPHPLRPHVVWFGEM-PLGLDRI 165
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
gi 2427736851 166 YSALAQCNLFISIGTSGAVYP 186
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
2-216 |
1.04e-61 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 193.35 E-value: 1.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 2 VQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALARL 81
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQ--PNKAHYFLAEL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 82 ERLLPgRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDL----HQEELCSCCQFphPLRPHVVWFGE 157
Cdd:cd01413 79 EKQGI-IKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVKyakkHEVPRCPKCGG--IIRPDVVLFGE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2427736851 158 M-PLGLDRI-YSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFD 216
Cdd:cd01413 156 PlPQALLREaIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIAD 216
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
2-216 |
5.66e-41 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 140.58 E-value: 5.66e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 2 VQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRVEdvaTPEGY------ARDPElvqRFYNARRHQLQRAEIHPNPAH 75
Cdd:cd01411 5 LKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYKY---SPEYLlshdflEREPE---KFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 76 YALARLERLlpGRVTLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEWRGDLhQEELCSCCqfpHP-LRPHVVW 154
Cdd:cd01411 79 QKMAELEKM--GLKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYL-KSPYHAKC---GGvIRPDIVL 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2427736851 155 FGEMP--LGLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGlNGAHTVELNLEPSEVGSQFD 216
Cdd:cd01411 153 YEEMLneSVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQ-AGANLIAINKEPTQLDSPAT 215
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
1-218 |
4.53e-39 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 136.97 E-value: 4.53e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFR-ACDGLWEEHRVEDVATPEGYARDPElvqRFYNARRHQLQRAEIHPNPAHYALA 79
Cdd:PTZ00409 24 MIRKCKYVVALTGSGTSAESNIPSFRgPSSSIWSKYDPKIYGTIWGFWKYPE---KIWEVIRDISSDYEIELNPGHVALS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 80 RLERLlpGRV-TLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVIEwrgdLHQEELCSCCQFPHPL---------- 148
Cdd:PTZ00409 101 TLESL--GYLkFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQ----LNKIMLQKTSHFMHQLppecpcggif 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2427736851 149 RPHVVWFGE-MPLGLDR-IYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSEVGSQFDEK 218
Cdd:PTZ00409 175 KPNVILFGEvIPKSLLKqAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKTYITNRISDY 246
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
6-210 |
4.64e-34 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 122.02 E-value: 4.64e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRACDGLWEEHRvedvatPEGYARDpelvqrfynaRRHQLQRAEihPNPAHYALARLERll 85
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLP------EDKGRRR----------FSWRFRRAE--PTLTHMALVELER-- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 86 PGRVT-LVTQNIDNLHESAG--SKNLIHMHGELLKARCPGSGQ------VIEWRGDLHQEELCSCCQfpHPLRPHVVWFG 156
Cdd:cd01410 61 AGLLKfVISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPeyvrddVVETRGDKETGRRCHACG--GILKDTIVDFG 138
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2427736851 157 E-MPLG-LDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNLEPSE 210
Cdd:cd01410 139 ErLPPEnWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTP 194
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
2-196 |
7.32e-31 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 115.09 E-value: 7.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 2 VQSAKHIVILTGAGISAESGIKTFRACDGLWeeHRVEDVATPEGYARDPELVQRfYNARRH----QLQRAeiHPNPAHYA 77
Cdd:cd01409 5 VARSRRLLVLTGAGISTESGIPDYRSEGGLY--SRTFRPMTHQEFMRSPAARQR-YWARSFvgwpRFSAA--QPNAAHRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 78 LARLERLlpGRVT-LVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQVI--------------EWR---------GD- 132
Cdd:cd01409 80 LAALEAA--GRLHgLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTpraelqdrlealnpGFAeqaagqapdGDv 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2427736851 133 ---LHQEE-----LCSCCQfpHPLRPHVVWFGEM--PLGLDRIYSALAQCNLFISIGTSGAVYPAAGFV---HEAGL 196
Cdd:cd01409 158 dleDEQVAgfrvpECERCG--GVLKPDVVFFGENvpRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVlaaAEAGL 232
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
1-206 |
2.44e-29 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 110.68 E-value: 2.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 1 MVQSAKHIVILTGAGISAESGIKTFRACDGLWEEHRvEDVATPEGYARDPELVQRFYNARRHQLQRAEihPNPAHYALAR 80
Cdd:PRK14138 7 LLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYP-QNVFDIDFFYSHPEEFYRFAKEGIFPMLEAK--PNLAHVLLAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 81 LER--LLPGrvtLVTQNIDNLHESAGSKNLIHMHGELLKARCPGSGQ---VIEWRGDLHQEELCSCCQFPHPLRPHVVWF 155
Cdd:PRK14138 84 LEEkgLIEA---VITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKrytVEDVIEKLEKSDVPRCDDCSGLIRPNIVFF 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2427736851 156 GE-MPL-GLDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNGAHTVELNL 206
Cdd:PRK14138 161 GEaLPQdALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNL 213
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
2-206 |
4.65e-25 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 100.14 E-value: 4.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 2 VQSAKHIVILTGAGISAESGIKTFRACDGLW--------EEHRVEDVATPEGYARDPELVQRFYNARrhqlqraeihPNP 73
Cdd:PRK05333 16 VERHPRLFVLTGAGISTDSGIPDYRDRNGQWkrsppityQAFMGSDAARRRYWARSMVGWPVFGRAQ----------PNA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 74 AHYALARLERllPGRVT-LVTQNIDNLHESAGSKNLIHMHGELLKARCPGSG--------QVI------EWR-------- 130
Cdd:PRK05333 86 AHHALARLGA--AGRIErLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGarhpraeiQHVleaanpEWLaleaapap 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 131 -GDLHQEEL---------CSCCQfpHPLRPHVVWFGE-MPLG-LDRIYSALAQCNLFISIGTSGAVYPAAGFVHEAGLNG 198
Cdd:PRK05333 164 dGDADLEWAafdhfrvpaCPACG--GILKPDVVFFGEnVPRErVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQG 241
|
....*...
gi 2427736851 199 AHTVELNL 206
Cdd:PRK05333 242 KPIAALNL 249
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
6-208 |
1.05e-22 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 92.69 E-value: 1.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRACD-GLWEEHRVEDVATPEG------YARDPELvqrFYNARRHqLQRAEIHPNPAHYAL 78
Cdd:cd01408 1 KKIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPYPEAmfdisyFRKNPRP---FYALAKE-LYPGQFKPSVAHYFI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 79 ARLE---RLLpgrvTLVTQNIDNLHESAG--SKNLIHMHGELLKARCPGSGQVI--EW-RGDLHQEELCSCCQFPHPLRP 150
Cdd:cd01408 77 KLLEdkgLLL----RNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYpgDWmREDIFNQEVPKCPRCGGLVKP 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2427736851 151 HVVWFGE-MPlglDRIYSA----LAQCNLFISIGTSGAVYPAAGFVHEAGlNGAHTVELNLEP 208
Cdd:cd01408 153 DIVFFGEsLP---SRFFSHmeedKEEADLLIVIGTSLKVAPFASLPSRVP-SEVPRVLINREP 211
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
8-188 |
3.76e-08 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 53.33 E-value: 3.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 8 IVILTGAGISAESGIKTFRACD-GLWEEHRVEDVATPEGYARDPELVQR---FYN-ARRHQLQRAEIHPNPAHYALARLE 82
Cdd:PTZ00410 32 ILVMVGAGISVAAGIPDFRSPHtGIYAKLGKYNLNSPTDAFSLTLLREKpevFYSiAREMDLWPGHFQPTAVHHFIRLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 83 ---RLLpgrvTLVTQNIDNLHESAG--SKNLIHMHGELLKARCpgsgqvIEWRG--DLHQEELCS-------CCQFPHPL 148
Cdd:PTZ00410 112 degRLL----RCCTQNIDGLERAAGvpPSLLVEAHGSFSAASC------IECHTpyDIEQAYLEArsgkvphCSTCGGIV 181
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2427736851 149 RPHVVWFGE-MPLGLDRIYSALAQCNLFISIGTSGAVYPAA 188
Cdd:PTZ00410 182 KPDVVFFGEnLPDAFFNVHHDIPEAELLLIIGTSLQVHPFA 222
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
6-113 |
6.02e-07 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 48.94 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427736851 6 KHIVILTGAGISAESGIKTFRA-CDGLWEEHRVEDVA------TPEGYARDPELV-------QRFYNARRHQLQRAEIHP 71
Cdd:cd01406 1 GRVVIFVGAGVSVSSGLPDWKTlLDEIASELGLEIDGysveakDENDYLELAELLekefgtiGIKINAVLEEKTRPDFEP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2427736851 72 NPAHYALARLERLLPGRVTLVTQNIDNLHE----------------------SAGSKNLIHMHG 113
Cdd:cd01406 81 SPLHELLLRLFINNEGDVIIITTNYDRLLEtalkeinkvvkvivsvqlalsaSARFNGVYKIHG 144
|
|
| |
