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Conserved domains on  [gi|2427903675|ref|WP_270710047|]
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helix-turn-helix transcriptional regulator [Bacillus cereus group sp. TH160LC]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-41 4.75e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 42.68  E-value: 4.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2427903675   1 MSIGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRR 41
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRN 46
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-41 4.75e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 42.68  E-value: 4.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2427903675   1 MSIGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRR 41
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRN 46
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-48 1.44e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 37.92  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2427903675   4 GKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPsLETLEK 46
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-48 4.95e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.73  E-value: 4.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2427903675   10 ARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKRKPsLETLKK 44
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-48 5.33e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 36.36  E-value: 5.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2427903675   7 VAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPsLETLKK 43
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-41 4.75e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 42.68  E-value: 4.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2427903675   1 MSIGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRR 41
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRN 46
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-40 8.47e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 41.76  E-value: 8.47e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2427903675   1 MSIGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQR 40
Cdd:COG1476     3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKY 42
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-48 1.44e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 37.92  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2427903675   4 GKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPsLETLEK 46
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 3-48 3.57e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.22  E-value: 3.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2427903675   3 IGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRLPEDLRK 48
Cdd:COG1813    13 YGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLR 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-48 4.95e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.73  E-value: 4.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2427903675   10 ARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:smart00530   5 LREEKGLTQEELAEKLGVSRSTLSRIENGKRKPsLETLKK 44
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-48 5.33e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 36.36  E-value: 5.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2427903675   7 VAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRL-PEDLRK 48
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPsLETLKK 43
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 3-43 1.46e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 35.58  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2427903675   3 IGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRLP 43
Cdd:pfam13560   2 LGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGRP 42
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 4-45 1.50e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 35.34  E-value: 1.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2427903675   4 GKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQRRLPED 45
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAE 42
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-45 9.14e-03

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 33.62  E-value: 9.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2427903675   1 MSIGKEVAMARKRKGITQEQLSLEIPVSRESLAKYETEQR-RLPED 45
Cdd:COG1426     4 ETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFdALPGP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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