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Conserved domains on  [gi|2443352732|ref|WP_273009770|]
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AraC family transcriptional regulator [Alcanivorax sp.]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117664)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain and an N-terminal arabinose binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  12596232|10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-209 1.74e-34

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 124.68  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  25 GIDRQTCLLGTGIADEALSSGEGLVTRTQEMRLIENLMLALPAAGVGgFELGRQYNLATFGVWGFALRTCKTLRDAAALG 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALG-LRLGRRLRPGSLGLLGYAALSSPTLGEALDRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 105 VRYLPLSTAYCRITVCEQ-GDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDVAASAVAE 183
Cdd:pfam12625  80 LRYLRLLSDALELRLEEGeGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2443352732 184 LCGVMPTFHARANR*LVNRAGANQPF 209
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
97-333 3.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.08  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  97 LRDAAALGVRYLPLSTAYCRITVCEQGDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDV 176
Cdd:COG2207    14 LALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 177 AASAVAELCGVMPTFHARANR*LVNRAGANQPFPGYDPVLTRMLEQQCRQRMDTVESSGVAGKVRQKLLGELGLGATLND 256
Cdd:COG2207    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEE 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2443352732 257 MASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:COG2207   174 LARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-209 1.74e-34

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 124.68  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  25 GIDRQTCLLGTGIADEALSSGEGLVTRTQEMRLIENLMLALPAAGVGgFELGRQYNLATFGVWGFALRTCKTLRDAAALG 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALG-LRLGRRLRPGSLGLLGYAALSSPTLGEALDRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 105 VRYLPLSTAYCRITVCEQ-GDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDVAASAVAE 183
Cdd:pfam12625  80 LRYLRLLSDALELRLEEGeGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2443352732 184 LCGVMPTFHARANR*LVNRAGANQPF 209
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
97-333 3.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.08  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  97 LRDAAALGVRYLPLSTAYCRITVCEQGDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDV 176
Cdd:COG2207    14 LALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 177 AASAVAELCGVMPTFHARANR*LVNRAGANQPFPGYDPVLTRMLEQQCRQRMDTVESSGVAGKVRQKLLGELGLGATLND 256
Cdd:COG2207    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEE 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2443352732 257 MASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:COG2207   174 LARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
253-333 8.17e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 87.61  E-value: 8.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  253 TLNDMASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSE 331
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 2443352732  332 YR 333
Cdd:smart00342  83 YR 84
HTH_18 pfam12833
Helix-turn-helix domain;
257-333 3.16e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 72.62  E-value: 3.16e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2443352732 257 MASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLL-SNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 214-333 3.25e-13

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 68.80  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 214 PVLTRMLEQQCRQRMDTVESSGVAGKvrqkllgelglgATLNDMASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQ 293
Cdd:PRK09978  133 PLLLNVLQPNMRTRVCTVINNNIAHE------------WTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQ 200

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2443352732 294 LLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK09978  201 LIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-209 1.74e-34

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 124.68  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  25 GIDRQTCLLGTGIADEALSSGEGLVTRTQEMRLIENLMLALPAAGVGgFELGRQYNLATFGVWGFALRTCKTLRDAAALG 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALG-LRLGRRLRPGSLGLLGYAALSSPTLGEALDRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 105 VRYLPLSTAYCRITVCEQ-GDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDVAASAVAE 183
Cdd:pfam12625  80 LRYLRLLSDALELRLEEGeGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2443352732 184 LCGVMPTFHARANR*LVNRAGANQPF 209
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
97-333 3.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.08  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  97 LRDAAALGVRYLPLSTAYCRITVCEQGDTFGVTFDPDPIPAHLRQFLLERDMATALNLVREITLQGVAFTGIEFTGEPDV 176
Cdd:COG2207    14 LALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 177 AASAVAELCGVMPTFHARANR*LVNRAGANQPFPGYDPVLTRMLEQQCRQRMDTVESSGVAGKVRQKLLGELGLGATLND 256
Cdd:COG2207    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEE 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2443352732 257 MASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:COG2207   174 LARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
253-333 8.17e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 87.61  E-value: 8.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732  253 TLNDMASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSE 331
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 2443352732  332 YR 333
Cdd:smart00342  83 YR 84
HTH_18 pfam12833
Helix-turn-helix domain;
257-333 3.16e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 72.62  E-value: 3.16e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2443352732 257 MASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLL-SNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 214-333 3.25e-13

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 68.80  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 214 PVLTRMLEQQCRQRMDTVESSGVAGKvrqkllgelglgATLNDMASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQ 293
Cdd:PRK09978  133 PLLLNVLQPNMRTRVCTVINNNIAHE------------WTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQ 200

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2443352732 294 LLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK09978  201 LIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 253-333 4.71e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 65.95  E-value: 4.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 253 TLNDMASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSE 331
Cdd:COG4977   228 SVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSA 307


                  ..
gi 2443352732 332 YR 333
Cdd:COG4977   308 YR 309
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 236-332 1.21e-07

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 52.38  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 236 VAGKVRQKLLGELGLGATLNDMASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAG 315
Cdd:PRK15186  182 LAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSAS 261

                          90
                  ....*....|....*..
gi 2443352732 316 GFVRAFRRWQGCSPSEY 332
Cdd:PRK15186  262 YFTCVFKKHFKTTPSEF 278
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 254-332 2.97e-07

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 51.15  E-value: 2.97e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2443352732 254 LNDMASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEY 332
Cdd:PRK15185  225 LTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
ftrA PRK09393
transcriptional activator FtrA; Provisional
 233-333 6.37e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 50.35  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 233 SSGVAGKVRQKLLGELGLGATLNDMASELALSSRS-LRRKLEQEGTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAY 311
Cdd:PRK09393  216 ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTfLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGF 295

                          90       100
                  ....*....|....*....|..
gi 2443352732 312 TDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK09393  296 GSEESLRHHFRRRAATSPAAYR 317
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
284-333 1.96e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 48.82  E-value: 1.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2443352732 284 EEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK10572  233 EDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFR 282
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 257-333 3.14e-06

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 48.10  E-value: 3.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2443352732 257 MASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQLLSNTTM--KIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK09685  220 IAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDRCADDLRPAADdeKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYR 298
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 236-333 4.67e-06

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 47.39  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 236 VAGKVRQKLLGELGLGATLNDMASELALSSRSLRRKLEQEGTSYRDLVEEERRQLALQLLsNTTMKIEEIAAHLAYTDAG 315
Cdd:PRK09940  135 VSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLI-RVEGSVNKIAEQCGYASTS 213

                          90       100
                  ....*....|....*....|..
gi 2443352732 316 GFVRAFRRWQGCSP----SEYR 333
Cdd:PRK09940  214 YFIYAFRKHFGNSPkrvsKEYR 235
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 253-333 2.55e-05

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 45.43  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 253 TLNDMASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSnTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSE 331
Cdd:COG2169   102 SLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSA 180


                  ..
gi 2443352732 332 YR 333
Cdd:COG2169   181 YR 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 294-333 5.11e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 39.83  E-value: 5.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2443352732 294 LLSNTT--MKIEEIAAHLAYtDAGGFVRAFRRWQGCSPSEYR 333
Cdd:pfam00165   1 LRENLStnLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYR 41
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
281-333 1.02e-03

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 38.37  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2443352732 281 DLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFRRWQGCSPSEYR 333
Cdd:PRK10219   52 DYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYR 104
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
244-333 4.75e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 38.35  E-value: 4.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443352732 244 LLGELGLGATLNDMASELALSSRSLRRKLEQE-GTSYRDLVEEERRQLALQLLSNTTMKIEEIAAHLAYTDAGGFVRAFR 322
Cdd:PRK13501  185 LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQtGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFT 264

                          90
                  ....*....|.
gi 2443352732 323 RWQGCSPSEYR 333
Cdd:PRK13501  265 REAGMTPRDYR 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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