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Conserved domains on  [gi|2444576009|ref|WP_273594821|]
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nucleotide exchange factor GrpE [Roseateles koreensis]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793971)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 3-180 5.08e-80

heat shock protein GrpE; Provisional


:

Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 235.64  E-value: 5.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009   3 TAQTPQPDLSSDQAAAADVGADGAAAHPAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEAL 82
Cdd:PRK14139    9 SEQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  83 LPVMDSMEAAIAMPDAKVETVLEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 162
Cdd:PRK14139   89 LPVKDSLEAALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINP-VGEKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 167

                         170
                  ....*....|....*...
gi 2444576009 163 TIADRVLRPALITVSAPR 180
Cdd:PRK14139  168 TIADRVLRPALVTVAAPK 185
 
Name Accession Description Interval E-value
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 3-180 5.08e-80

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 235.64  E-value: 5.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009   3 TAQTPQPDLSSDQAAAADVGADGAAAHPAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEAL 82
Cdd:PRK14139    9 SEQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  83 LPVMDSMEAAIAMPDAKVETVLEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 162
Cdd:PRK14139   89 LPVKDSLEAALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINP-VGEKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 167

                         170
                  ....*....|....*...
gi 2444576009 163 TIADRVLRPALITVSAPR 180
Cdd:PRK14139  168 TIADRVLRPALVTVAAPK 185
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 36-179 8.98e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 169.95  E-value: 8.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  36 AEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAM--PDAKVETVLEGVHATKRQ 113
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAaeEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 114 LAAALERNKVLEINPaAGVKFDPHQHQAISMVPA-EQEPNTVVAVLQKGYTIADRVLRPALITVSAP 179
Cdd:COG0576    82 LLDVLEKHGVEEIEP-VGEPFDPNLHEAVSQVPSpDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 43-176 9.29e-51

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 159.59  E-value: 9.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  43 AEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP--DAKVETVLEGVHATKRQLAAALER 120
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAApkEEELKNLLEGVEMTLKQLLKVLEK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 121 NKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITV 176
Cdd:cd00446    81 HGVEEIEP-EGEKFDPNLHEAVMQVESPDkEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
32-177 3.65e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 158.93  E-value: 3.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAM--PDAKVETVLEGVHA 109
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSapENEDVKSLLEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2444576009 110 TKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:pfam01025  97 TLKQLLKILEKHGVEKIEP-EGEPFDPNLHEAVSQVPSPEkPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
 
Name Accession Description Interval E-value
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 3-180 5.08e-80

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 235.64  E-value: 5.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009   3 TAQTPQPDLSSDQAAAADVGADGAAAHPAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEAL 82
Cdd:PRK14139    9 SEQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  83 LPVMDSMEAAIAMPDAKVETVLEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 162
Cdd:PRK14139   89 LPVKDSLEAALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINP-VGEKFDPHQHQAISMVPAEQEPNTVVAVLQKGY 167

                         170
                  ....*....|....*...
gi 2444576009 163 TIADRVLRPALITVSAPR 180
Cdd:PRK14139  168 TIADRVLRPALVTVAAPK 185
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 36-179 8.98e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 169.95  E-value: 8.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  36 AEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAM--PDAKVETVLEGVHATKRQ 113
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAaeEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 114 LAAALERNKVLEINPaAGVKFDPHQHQAISMVPA-EQEPNTVVAVLQKGYTIADRVLRPALITVSAP 179
Cdd:COG0576    82 LLDVLEKHGVEEIEP-VGEPFDPNLHEAVSQVPSpDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 43-176 9.29e-51

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 159.59  E-value: 9.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  43 AEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP--DAKVETVLEGVHATKRQLAAALER 120
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAApkEEELKNLLEGVEMTLKQLLKVLEK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 121 NKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITV 176
Cdd:cd00446    81 HGVEEIEP-EGEKFDPNLHEAVMQVESPDkEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
32-177 3.65e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 158.93  E-value: 3.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAM--PDAKVETVLEGVHA 109
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSapENEDVKSLLEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2444576009 110 TKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:pfam01025  97 TLKQLLKILEKHGVEKIEP-EGEPFDPNLHEAVSQVPSPEkPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 30-178 8.00e-48

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 153.92  E-value: 8.00e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVESRLAEMS----DAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDAKVETV-- 103
Cdd:PRK14150   38 EADARIAELEAQLAEAQaeerDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVIDNLERALQAADKENEALka 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 104 -LEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITVSA 178
Cdd:PRK14150  118 lIEGVELTLKSLLDTVAKFGVEVVGP-VGEPFNPEVHQAISMQESEDhEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 31-178 2.08e-41

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 137.82  E-value: 2.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  31 AEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP--DAKVETVLEGVH 108
Cdd:PRK14140   42 EQAKIAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEadDEQTKSLLKGVE 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2444576009 109 ATKRQLAAALERNKVlEINPAAGVKFDPHQHQAI-SMVPAEQEPNTVVAVLQKGYTIADRVLRPALITVSA 178
Cdd:PRK14140  122 MVHRQLLEALKKEGV-EVIEAVGEQFDPNLHQAVmQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 33-177 4.87e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 123.35  E-value: 4.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  33 AKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDAKVETV---LEGVHA 109
Cdd:PRK14151   27 ARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGLELSSADDEAIkpmREGVEL 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2444576009 110 TKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14151  107 TLKMFQDTLKRYQLEAVDP-HGEPFNPEHHQAMAMQEsADVEPNSVLKVFQKGYLLNGRLLRPAMVVVS 174
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 30-177 2.11e-34

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 120.16  E-value: 2.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAI--------AMPDAKVE 101
Cdd:PRK14141   35 PEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALdaipaearAAADAGLK 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 102 TVLEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQEP-NTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14141  115 ALIEGVEMTERAMLNALERHGVKKLDP-EGQKFDPNFHQAMFEVPNPDVPnNTVVQVVQAGYTIGERVLRPAMVGVA 190
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 29-177 4.32e-34

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 119.44  E-value: 4.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  29 HPA----EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPD-AKVETV 103
Cdd:PRK14144   44 HPSytalEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQALQLADkNSDPSM 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2444576009 104 LEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPA-EQEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14144  124 HEGLELTMKLFLDALQKFDVEQIDP-LGQTFDPQQHEAMSMQPApGAPPNSVITVFQKGYKLSDRVIRPARVIVS 197
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 30-178 3.34e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 109.67  E-value: 3.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVesrlAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP-----DAKVETVL 104
Cdd:PRK14155   21 EIEALKAEV----AALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASpkdsaDPAVKNFI 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2444576009 105 EGVHATKRQLAAALERNKVLEINPAAGVKFDPHQHQAISMVPA-EQEPNTVVAVLQKGYTIADRVLRPALITVSA 178
Cdd:PRK14155   97 IGVEMTEKELLGAFERNGLKKIDPAKGDKFDPHLHQAMMEQPStEVAAGGVLQVMQAGYELMGRLVRPAMVAVAA 171
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 31-176 1.80e-29

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 107.15  E-value: 1.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  31 AEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMpDAKVETVL---EGV 107
Cdd:PRK14148   45 AKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKH-EVKLEEAIamkEGI 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009 108 HATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITV 176
Cdd:PRK14148  124 ELTAKMLVDILKKNGVEELDP-KGEKFDPNLHEAMAMIPnPEFEDNTIFDVFQKGYMLNGRIVRAAKVVI 192
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 31-177 1.06e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 105.30  E-value: 1.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  31 AEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP--DAKVETVLEGVH 108
Cdd:PRK14162   44 LEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVKadDEAAKQLKKGVQ 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2444576009 109 ATKRQLAAALERNKVLEINpAAGVKFDPHQHQAISMVPAE--QEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14162  124 MTLDHLVKALKDHGVTEIK-ADGEKFDPTLHQAVQTVAAEndDQKDHVVQVLQKGYQYKDRTLRPAMVVVA 193
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 8-178 3.70e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 103.11  E-value: 3.70e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009   8 QPDLSSDQAAAADVGADgaaahPAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMD 87
Cdd:PRK14147    5 HPEFDSEDLAQNPPETD-----PLKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  88 SMEAAIAMPDAKVETVLEGVHATKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIAD 166
Cdd:PRK14147   80 SLDAGLTAAGTEPSPLRDGLELTYKQLLKVAADNGLTLLDP-VGQPFNPEHHQAISQGEAEGvAPGHVVQVFQKGYLLNE 158

                         170
                  ....*....|..
gi 2444576009 167 RVLRPALITVSA 178
Cdd:PRK14147  159 RLLRPALVVVAK 170
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 30-177 6.68e-28

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 103.21  E-value: 6.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVESRLAEMS----DAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDAK---VET 102
Cdd:PRK10325   39 PRDEKIANLEAQLAEAQtrerDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKAnpdMSA 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2444576009 103 VLEGVHATKRQLAAALERNKVlEINPAAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK10325  119 MVEGIELTLKSMLDVVRKFGV-EVIAETNVPLDPNVHQAIAMVESDDvAPGNVLGIMQKGYTLNGRTIRAAMVTVA 193
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 34-177 3.27e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 100.92  E-value: 3.27e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  34 KLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP--DAKVETVLEGVHATK 111
Cdd:PRK14159   31 EQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVEchDEISLKIKEGVQNTL 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2444576009 112 RQLAAALERNKVLEINPAAgvKFDPHQHQAISMVPAE-QEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14159  111 DLFLKKLEKHGVALIKEEK--EFDPNLHEAMFHVDSEnHQSGEVVQVLQKGYKIADRVIRPTKVSVA 175
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 32-177 7.40e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 100.39  E-value: 7.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDAK-VETVLEGVHAT 110
Cdd:PRK14158   46 EEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALDHADEEsMSAIIEGIRMT 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2444576009 111 KRQLAAALERNKVLEINPAAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14158  126 LSMLLSTLKKFGVTPVEAEKGTPFDPAYHQAMCQVEsAEQEPNTVVAVFQKGYLLNERLLRPAMVSVA 193
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 31-176 2.03e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 98.89  E-value: 2.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  31 AEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP----DAKVETVLEG 106
Cdd:PRK14161   24 ANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKpansDVEVTNIIAG 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2444576009 107 VHATKRQLAAALERNKVLEINPAAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITV 176
Cdd:PRK14161  104 VQMTKDELDKVFHKHHIEEIKPEIGSMFDYNLHNAISQIEhPDHAPNSIITLMQSGYKIRDRLLRPATVQV 174
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 36-176 3.16e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 93.40  E-value: 3.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  36 AEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAI--AMPDAKVETVLEGVHATKRQ 113
Cdd:PRK14149   46 EDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALksAAEVDKESALTKGLELTMEK 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2444576009 114 LAAALERNKVLEInpAAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITV 176
Cdd:PRK14149  126 LHEVLARHGIEGI--ECLEEFDPNFHNAIMQVKsEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 187
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 32-178 5.03e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 91.02  E-value: 5.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMP---DAKVETVLEGVH 108
Cdd:PRK14154   58 EGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPaseDPQVKSMRDGMS 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2444576009 109 ATKRQLAAALERNKVLEINPAAGVKFDPHQHQAISM--VPaEQEPNTVVAVLQKGYTIADRVLRPALITVSA 178
Cdd:PRK14154  138 LTLDLLHNTLAKHGVQVINPNPGDPFDPALHEAMSVqaVP-DAKPDTIIQVLQKGYQLNGRVLRAARVIVAG 208
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 34-177 1.29e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 86.90  E-value: 1.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  34 KLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAmPDAKVETVLEGVHATKRQ 113
Cdd:PRK14145   53 KLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNFERALA-SSGDYNSLKEGIELIYRQ 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2444576009 114 LAAALERNKVLEINpAAGVKFDPHQHQAISMVPAE-QEPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14145  132 FKKILDKFGVKEIE-AEGQIFDPYKHHAVMQEEVEgKQPNEIIEVFQKGYYLKDKVIRPSLVKVA 195
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 30-177 9.06e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 84.51  E-value: 9.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAI--AMPDAKVETVLEGV 107
Cdd:PRK14153   37 TADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALesARTAEDMNSIVEGI 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2444576009 108 HATKRQLAAALERNKVLEINPAAGvKFDPHQHQAISMVPAEQEP-NTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14153  117 EMVSKQFFSILEKYGLERIECEGE-EFDPHRHEAMMHVETSEVPdNTIVDVCKPGYALNSKVIRPAMVSVA 186
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 30-177 5.57e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 79.49  E-value: 5.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  30 PAEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMpDAKVETVLEGVHA 109
Cdd:PRK14156   31 PEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERALAV-EGLTDDVKKGLEM 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009 110 TKRQLAAALERNKVLEInpaAGVKFDPHQHQAISMVPAEQE--PNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14156  110 VQESLIQALKEEGVEEV---AVDSFDHNLHMAVQTLPADDEhpADSIAQVFQKGYKLHERLLRPAMVVVY 176
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 32-180 5.66e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 77.85  E-value: 5.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESrlaeMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSME--AAIAMPDAKVETVLEGVHA 109
Cdd:PRK14146   64 DNAKKEIES----LKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLErvGATQNQSEELKPFVEGVKM 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2444576009 110 TKRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIAD----RVLRPALITVSAPR 180
Cdd:PRK14146  140 ILKEFYSVLEKSNVIRFDP-KGEPFDPMSMEALSSEEGDQySEETVIDVYQAGYYYKEnedkFTLRPARVRIGKPK 214
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 39-177 4.58e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 75.18  E-value: 4.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  39 ESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMpDAKVETVLEGVHATKRQLAAAL 118
Cdd:PRK14160   74 ENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAAV-EGSVEDLKKGIEMTVKQFKTSL 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009 119 ERNKVLEInPAAGvKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALITVS 177
Cdd:PRK14160  153 EKLGVEEI-STEG-EFDPNLHNAVMHVEDENyGENEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 32-179 1.05e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 66.67  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDAKVETVLE------ 105
Cdd:PRK14143   73 EQELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQAlhrsyq 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2444576009 106 GVHatkRQLAAALERNKVLEINPaAGVKFDPHQHQAISMVPAEQEPNTVVAV-LQKGYTIADRVLRPALITVSAP 179
Cdd:PRK14143  153 GLY---KQLVDVLKRLGVSPMRV-VGQEFDPNLHEAVLREPSDEHPEDVVLEeLQRGYHLGGRVLRHAMVKVSMG 223
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 33-180 2.19e-12

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 62.84  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  33 AKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPD--AKVETVLEGVHAT 110
Cdd:PRK14163   47 AQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRAREHGElvGGFKSVAESLETT 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2444576009 111 KRQLAaalernkvLEINPAAGVKFDPHQHQAI--SMVPAEQEpNTVVAVLQKGYTIADRVLRPALITVSAPR 180
Cdd:PRK14163  127 VAKLG--------LQQFGKEGEPFDPTIHEALmhSYAPDVTE-TTCVAILQPGYRIGERTIRPARVAVAEPQ 189
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 35-180 2.29e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 57.27  E-value: 2.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  35 LAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSME---AAIAMPDAkvetvlegVHATK 111
Cdd:PRK14157   86 LGQAKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDrirEHSEMDDS--------FKAVA 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009 112 RQLAAALERNKVlEINPAAGVKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVLRPALITVSAPR 180
Cdd:PRK14157  158 AKIDKAFEKFGV-EKFGEKGEDFDPTKHDAILHKPdPDAEKETVDTVVEAGYRIGDRVIRAARVVVASPQ 226
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 32-179 3.05e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 56.73  E-value: 3.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  32 EAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDakvetVLEG-VHAT 110
Cdd:PRK14164   76 DGEASTVEAQLAERTEDLQRVTAEYANYRRRTERERQAIIETAKAGVATDLLPILDDLDLAEQHGD-----LNEGpLKAF 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2444576009 111 KRQLAAALERNKVlEINPAAGVKFDPHQHQAISMVPAEQEpNTVVAVLQKGYTIADRVLRPALITVSAP 179
Cdd:PRK14164  151 SDKLTNVLAGLKV-EKFGEEGDAFDPEIHEAVQDLSSGDE-KVLGTVLRKGYRMGDRVLRTAMVIIADP 217
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 31-176 8.10e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 41.52  E-value: 8.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009  31 AEAKLAEVESRLAEMSDAYLRAKAEVENIRRRSEDEMSKARKFAVESFAEALLPVMDSMEAAIAMPDakvetvLEG--VH 108
Cdd:PRK14142   38 AAADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGD------LESgpLK 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444576009 109 ATKRQLAAALERNKVLEINpAAGVKFDPHQHQAISMVPAEQEPNTVV--AVLQKGYTIADRVLRPALITV 176
Cdd:PRK14142  112 SVADKLDSALTGLGLVAFG-AEGEDFDPVLHEAVQHEGDGGQGSKPVigTVMRQGYQLGEQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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