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Conserved domains on  [gi|2485719434|ref|WP_278525155|]
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FAD-dependent oxidoreductase [Brucella anthropi]

Protein Classification

glycine oxidase ThiO( domain architecture ID 1006289)

glycine oxidase ThiO catalyzes the oxidation of glycine, leading to glyoxyl imine and hydrogen peroxide as primary products; glyoxyl imine is used for the biosynthesis of the thiazole ring of thiamine

CATH:  3.30.9.10|3.50.50.60
EC:  1.4.3.19
Gene Ontology:  GO:0050660|GO:0043799|GO:0016491|GO:0009228

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
thiamin_ThiO super family cl37093
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 23-309 1.44e-73

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


The actual alignment was detected with superfamily member TIGR02352:

Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 230.71  E-value: 1.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  23 GHAVTVIAKStEIGSDScSWFAGGMLAPWCEGESAEEPVVRLGQEAIGWWERHVSTV----------HRKGTLVFSHTRD 92
Cdd:TIGR02352   7 GHSVTLFDRD-PMGGGA-SWAAAGMLAPHAECEYAEDPLFDLALESLRLYPEWLEALkeltgldtgyHQCGTLVVAFDED 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  93 ATELRRFAR---RTEAFDTI--DQDQIDTLEPDLAGRFRQGLFFAAEGHLNPRQTLIELAEKLQKKGVVFHLGQDAKDV- 166
Cdd:TIGR02352  85 DVEHLRQLAdlqSATGMEVEwlSGRALRRLEPYLSGGIRGAVFYPDDAHVDPRALLKALEKALEKLGVEIIEHTEVQHIe 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 167 --------------KVEADITVDARGLAARDQLQD-LRGVKGEMLVVRS-RDINLKRPIRLLHPRIPLYIVPRGDGVHMI 230
Cdd:TIGR02352 165 irgekvtaivtpsgDVQADQVVLAAGAWAGELLPLpLRPVRGQPLRLEApAVPLLNRPLRAVVYGRRVYIVPRRDGRLVV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 231 GATMIESDERGGISVRSTLELLSAAYALHPAFGEAEILETGVDARPAFPDNLPRVRRR---GKTVYVNGLYRHGFLLSPA 307
Cdd:TIGR02352 245 GATMEESGFDTTPTLGGIKELLRDAYTILPALKEARLLETWAGLRPGTPDNLPYIGEHpedRRLLIATGHYRNGILLAPA 324


                  ..
gi 2485719434 308 VA 309
Cdd:TIGR02352 325 TA 326
COG3380 super family cl34596
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-36 1.72e-07

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


The actual alignment was detected with superfamily member COG3380:

Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 52.19  E-value: 1.72e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG3380     4 PDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVG 39
 
Name Accession Description Interval E-value
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 23-309 1.44e-73

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 230.71  E-value: 1.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  23 GHAVTVIAKStEIGSDScSWFAGGMLAPWCEGESAEEPVVRLGQEAIGWWERHVSTV----------HRKGTLVFSHTRD 92
Cdd:TIGR02352   7 GHSVTLFDRD-PMGGGA-SWAAAGMLAPHAECEYAEDPLFDLALESLRLYPEWLEALkeltgldtgyHQCGTLVVAFDED 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  93 ATELRRFAR---RTEAFDTI--DQDQIDTLEPDLAGRFRQGLFFAAEGHLNPRQTLIELAEKLQKKGVVFHLGQDAKDV- 166
Cdd:TIGR02352  85 DVEHLRQLAdlqSATGMEVEwlSGRALRRLEPYLSGGIRGAVFYPDDAHVDPRALLKALEKALEKLGVEIIEHTEVQHIe 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 167 --------------KVEADITVDARGLAARDQLQD-LRGVKGEMLVVRS-RDINLKRPIRLLHPRIPLYIVPRGDGVHMI 230
Cdd:TIGR02352 165 irgekvtaivtpsgDVQADQVVLAAGAWAGELLPLpLRPVRGQPLRLEApAVPLLNRPLRAVVYGRRVYIVPRRDGRLVV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 231 GATMIESDERGGISVRSTLELLSAAYALHPAFGEAEILETGVDARPAFPDNLPRVRRR---GKTVYVNGLYRHGFLLSPA 307
Cdd:TIGR02352 245 GATMEESGFDTTPTLGGIKELLRDAYTILPALKEARLLETWAGLRPGTPDNLPYIGEHpedRRLLIATGHYRNGILLAPA 324


                  ..
gi 2485719434 308 VA 309
Cdd:TIGR02352 325 TA 326
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 2-314 6.37e-44

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 153.71  E-value: 6.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDScSWFAGGMLAPWCEgESAEEPVVRLGQEAIGWWERHVST--- 78
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGA-SGRNAGLIHPGLR-YLEPSELARLALEALDLWEELEEElgi 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  79 ---VHRKGTLVFSHTRDATELRRFARRTEAFD----TIDQDQIDTLEPDLAGrFRQGLFFAAEGHLNPRQTLIELAEKLQ 151
Cdd:pfam01266  79 dcgFRRCGVLVLARDEEEEALEKLLAALRRLGvpaeLLDAEELRELEPLLPG-LRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 152 KKGVVFHLGQDAKDVKVEADIT-----------VDARGLAARDQLQD-----LRGVKGEMLVVRSR-DINLKRPIRLL-H 213
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWgvvttgeadavVNAAGAWADLLALPglrlpVRPVRGQVLVLEPLpEALLILPVPITvD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 214 PRIPLYIVPRGDGVHMIGATMIESD-ERGGISVRSTLELLSAAYALHPAFGEAEILETGVdaRPaFPDNLPRVRRRGK-- 290
Cdd:pfam01266 238 PGRGVYLRPRADGRLLLGGTDEEDGfDDPTPDPEEIEELLEAARRLFPALADIERAWAGL--RP-LPDGLPIIGRPGSpg 314

                         330       340
                  ....*....|....*....|....
gi 2485719434 291 TVYVNGLYRHGFLLSPAVARMAVA 314
Cdd:pfam01266 315 LYLATGHGGHGLTLAPGIGKLLAE 338
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-312 1.73e-39

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 142.74  E-value: 1.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKStEIGSdSCSWFAGGMLAPWCeGESAEEPVVRLGQEAIGWWERHVST-- 78
Cdd:COG0665     3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLERG-RPGS-GASGRNAGQLRPGL-AALADRALVRLAREALDLWRELAAElg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  79 ----VHRKGTLVFSHT-RDATELRRFARRTEAFD----TIDQDQIDTLEPDLA-GRFRQGLFFAAEGHLNPRQTLIELAE 148
Cdd:COG0665    80 idcdFRRTGVLYLARTeAELAALRAEAEALRALGlpveLLDAAELREREPGLGsPDYAGGLYDPDDGHVDPAKLVRALAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 149 KLQKKGVVFHLGQDAKDVK---------------VEADITVDARGLAARDQLQDL------RGVKGEMLVVRSRDINLKR 207
Cdd:COG0665   160 AARAAGVRIREGTPVTGLEreggrvtgvrtergtVRADAVVLAAGAWSARLLPMLglrlplRPVRGYVLVTEPLPDLPLR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 208 PIrLLHPRIplYIVPRGDGVHMIGATMIESDERGGISVRSTLELLSAAYALHPAFGEAEILETGVDARPAFPDNLP---R 284
Cdd:COG0665   240 PV-LDDTGV--YLRPTADGRLLVGGTAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRPMTPDGLPiigR 316

                         330       340
                  ....*....|....*....|....*...
gi 2485719434 285 VRRRGKTVYVNGLYRHGFLLSPAVARMA 312
Cdd:COG0665   317 LPGAPGLYVATGHGGHGVTLAPAAGRLL 344
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-36 1.72e-07

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 52.19  E-value: 1.72e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG3380     4 PDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVG 39
PRK06753 PRK06753
hypothetical protein; Provisional
 1-35 2.23e-06

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 48.92  E-value: 2.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEI 35
Cdd:PRK06753    1 MKIAIIGAGIGGLTAAALLQEQGHEVKVFEKNESV 35
PRK07233 PRK07233
hypothetical protein; Provisional
 2-54 1.37e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 43.34  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIgsdscswfaGGMLAPWCEG 54
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQL---------GGLAASFEFG 44
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 1-29 8.48e-04

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 40.67  E-value: 8.48e-04
                          10        20
                  ....*....|....*....|....*....
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVI 29
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGV 29
HI0933_like pfam03486
HI0933-like protein;
2-37 3.61e-03

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 38.72  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGS 37
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGR 37
 
Name Accession Description Interval E-value
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 23-309 1.44e-73

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 230.71  E-value: 1.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  23 GHAVTVIAKStEIGSDScSWFAGGMLAPWCEGESAEEPVVRLGQEAIGWWERHVSTV----------HRKGTLVFSHTRD 92
Cdd:TIGR02352   7 GHSVTLFDRD-PMGGGA-SWAAAGMLAPHAECEYAEDPLFDLALESLRLYPEWLEALkeltgldtgyHQCGTLVVAFDED 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  93 ATELRRFAR---RTEAFDTI--DQDQIDTLEPDLAGRFRQGLFFAAEGHLNPRQTLIELAEKLQKKGVVFHLGQDAKDV- 166
Cdd:TIGR02352  85 DVEHLRQLAdlqSATGMEVEwlSGRALRRLEPYLSGGIRGAVFYPDDAHVDPRALLKALEKALEKLGVEIIEHTEVQHIe 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 167 --------------KVEADITVDARGLAARDQLQD-LRGVKGEMLVVRS-RDINLKRPIRLLHPRIPLYIVPRGDGVHMI 230
Cdd:TIGR02352 165 irgekvtaivtpsgDVQADQVVLAAGAWAGELLPLpLRPVRGQPLRLEApAVPLLNRPLRAVVYGRRVYIVPRRDGRLVV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 231 GATMIESDERGGISVRSTLELLSAAYALHPAFGEAEILETGVDARPAFPDNLPRVRRR---GKTVYVNGLYRHGFLLSPA 307
Cdd:TIGR02352 245 GATMEESGFDTTPTLGGIKELLRDAYTILPALKEARLLETWAGLRPGTPDNLPYIGEHpedRRLLIATGHYRNGILLAPA 324


                  ..
gi 2485719434 308 VA 309
Cdd:TIGR02352 325 TA 326
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 2-314 6.37e-44

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 153.71  E-value: 6.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDScSWFAGGMLAPWCEgESAEEPVVRLGQEAIGWWERHVST--- 78
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGA-SGRNAGLIHPGLR-YLEPSELARLALEALDLWEELEEElgi 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  79 ---VHRKGTLVFSHTRDATELRRFARRTEAFD----TIDQDQIDTLEPDLAGrFRQGLFFAAEGHLNPRQTLIELAEKLQ 151
Cdd:pfam01266  79 dcgFRRCGVLVLARDEEEEALEKLLAALRRLGvpaeLLDAEELRELEPLLPG-LRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 152 KKGVVFHLGQDAKDVKVEADIT-----------VDARGLAARDQLQD-----LRGVKGEMLVVRSR-DINLKRPIRLL-H 213
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWgvvttgeadavVNAAGAWADLLALPglrlpVRPVRGQVLVLEPLpEALLILPVPITvD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 214 PRIPLYIVPRGDGVHMIGATMIESD-ERGGISVRSTLELLSAAYALHPAFGEAEILETGVdaRPaFPDNLPRVRRRGK-- 290
Cdd:pfam01266 238 PGRGVYLRPRADGRLLLGGTDEEDGfDDPTPDPEEIEELLEAARRLFPALADIERAWAGL--RP-LPDGLPIIGRPGSpg 314

                         330       340
                  ....*....|....*....|....
gi 2485719434 291 TVYVNGLYRHGFLLSPAVARMAVA 314
Cdd:pfam01266 315 LYLATGHGGHGLTLAPGIGKLLAE 338
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-312 1.73e-39

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 142.74  E-value: 1.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKStEIGSdSCSWFAGGMLAPWCeGESAEEPVVRLGQEAIGWWERHVST-- 78
Cdd:COG0665     3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLERG-RPGS-GASGRNAGQLRPGL-AALADRALVRLAREALDLWRELAAElg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  79 ----VHRKGTLVFSHT-RDATELRRFARRTEAFD----TIDQDQIDTLEPDLA-GRFRQGLFFAAEGHLNPRQTLIELAE 148
Cdd:COG0665    80 idcdFRRTGVLYLARTeAELAALRAEAEALRALGlpveLLDAAELREREPGLGsPDYAGGLYDPDDGHVDPAKLVRALAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 149 KLQKKGVVFHLGQDAKDVK---------------VEADITVDARGLAARDQLQDL------RGVKGEMLVVRSRDINLKR 207
Cdd:COG0665   160 AARAAGVRIREGTPVTGLEreggrvtgvrtergtVRADAVVLAAGAWSARLLPMLglrlplRPVRGYVLVTEPLPDLPLR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434 208 PIrLLHPRIplYIVPRGDGVHMIGATMIESDERGGISVRSTLELLSAAYALHPAFGEAEILETGVDARPAFPDNLP---R 284
Cdd:COG0665   240 PV-LDDTGV--YLRPTADGRLLVGGTAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRPMTPDGLPiigR 316

                         330       340
                  ....*....|....*....|....*...
gi 2485719434 285 VRRRGKTVYVNGLYRHGFLLSPAVARMA 312
Cdd:COG0665   317 LPGAPGLYVATGHGGHGVTLAPAAGRLL 344
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-36 1.72e-07

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 52.19  E-value: 1.72e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG3380     4 PDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVG 39
PRK06753 PRK06753
hypothetical protein; Provisional
 1-35 2.23e-06

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 48.92  E-value: 2.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEI 35
Cdd:PRK06753    1 MKIAIIGAGIGGLTAAALLQEQGHEVKVFEKNESV 35
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-171 2.57e-05

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 45.31  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDScswfAGGMLAPWcegesaeepvvrlGQEA---IGWWERHVS 77
Cdd:COG0654     4 TDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDG----RGIALSPR-------------SLELlrrLGLWDRLLA 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  78 TVHRKGTLVFSHTRDATELRRFarrteafdtidqdqidtlePDLAGRFRQGLFFaaeghlnPRQTLIE-LAEKLQKKGVV 156
Cdd:COG0654    67 RGAPIRGIRVRDGSDGRVLARF-------------------DAAETGLPAGLVV-------PRADLERaLLEAARALGVE 120

                         170
                  ....*....|....*
gi 2485719434 157 FHLGQDAKDVKVEAD 171
Cdd:COG0654   121 LRFGTEVTGLEQDAD 135
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-36 6.42e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 44.44  E-value: 6.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVG 37
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-29 7.64e-05

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 44.14  E-value: 7.64e-05
                          10        20
                  ....*....|....*....|....*...
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVI 29
Cdd:COG1231     9 DVVIVGAGLAGLAAARELRKAGLDVTVL 36
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
5-52 7.76e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 40.21  E-value: 7.76e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2485719434   5 IIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDSCSWFAGGMLAPWC 52
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYG 48
PRK07233 PRK07233
hypothetical protein; Provisional
 2-54 1.37e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 43.34  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIgsdscswfaGGMLAPWCEG 54
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQL---------GGLAASFEFG 44
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 3-190 1.82e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 43.05  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   3 VTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGsdSCSWFAGGMLA-----PWCEGESAEEPV---------------- 61
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFG--GATAWSSGGIDalgnpPQGGIDSPELHPtdtlkgldeladhpyv 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  62 ---VRLGQEAIGWWERHvstvHRKGTLVFSHTRDATEL--RRFARRTeAFDTIDQDQIDTLEPDLAGRFRQGLfFAAEGH 136
Cdd:pfam00890  80 eafVEAAPEAVDWLEAL----GVPFSRTEDGHLDLRPLggLSATWRT-PHDAADRRRGLGTGHALLARLLEGL-RKAGVD 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2485719434 137 LNPRQTLIELAEKLQK-KGVVFHLGQDAKDVKVEADI-TVDARGlaARDQLQDLRG 190
Cdd:pfam00890 154 FQPRTAADDLIVEDGRvTGAVVENRRNGREVRIRAIAaVLLATG--GFGRLAELLL 207
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 3-201 2.22e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 42.90  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434   3 VTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDScSWFAGGMLAP------WCEGESAEEpvvrlgqeaigwwerhv 76
Cdd:COG1053     6 VVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHT-AAAQGGINAAgtnvqkAAGEDSPEE----------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485719434  77 stvHRKGTLVFSHTR-DATELRRFARrtEAFDTIDQdqidtLEpdlagrfRQGLFFAAE---------GHLNPR------ 140
Cdd:COG1053    68 ---HFYDTVKGGDGLaDQDLVEALAE--EAPEAIDW-----LE-------AQGVPFSRTpdgrlpqfgGHSVGRtcyagd 130

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2485719434 141 ---QTLIE-LAEKLQKKGVVFHLGQDAKDVKVEADitvDARGLAARDQlqdlrgvKGEMLVVRSR 201
Cdd:COG1053   131 gtgHALLAtLYQAALRLGVEIFTETEVLDLIVDDG---RVVGVVARDR-------TGEIVRIRAK 185
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 2-36 4.67e-04

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 41.69  E-value: 4.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:PRK12810  145 KVAVVGSGPAGLAAADQLARAGHKVTVFERADRIG 179
PLN02487 PLN02487
zeta-carotene desaturase
 1-42 4.89e-04

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 41.71  E-value: 4.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGSDSCSW 42
Cdd:PLN02487   76 LKVAIIGAGLAGMSTAVELLDQGHEVDIYESRPFIGGKVGSF 117
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 1-29 8.48e-04

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 40.67  E-value: 8.48e-04
                          10        20
                  ....*....|....*....|....*....
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVI 29
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGV 29
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 2-58 1.02e-03

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 40.86  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHaVTVIAKSTEigSDSCSWFA-GGMLAPWCEGESAE 58
Cdd:COG0029     6 DVLVIGSGIAGLSAALKLAERGR-VTLLTKGEL--GESNTRWAqGGIAAVLDPGDSPE 60
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 1-32 1.05e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 40.23  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKS 32
Cdd:COG1893     1 MKIAILGAGAIGGLLGARLARAGHDVTLVARG 32
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-34 1.09e-03

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 40.22  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTE 34
Cdd:PRK06522    1 MKIAILGAGAIGGLFGAALAQAGHDVTLVARRGA 34
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 2-36 1.41e-03

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 40.12  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG0493   123 KVAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPG 157
PRK08071 PRK08071
L-aspartate oxidase; Provisional
 2-49 1.48e-03

L-aspartate oxidase; Provisional


Pssm-ID: 236147 [Multi-domain]  Cd Length: 510  Bit Score: 40.36  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHaVTVIAKSTeiGSDSCSWFAGGMLA 49
Cdd:PRK08071    5 DVIIIGSGIAALTVAKELCHEYN-VIIITKKT--KRNSNSHLAQGGIA 49
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
2-36 1.54e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 40.23  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG1148   142 RALVIGGGIAGMTAALELAEQGYEVYLVEKEPELG 176
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-36 2.21e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 39.45  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG1233     4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPG 39
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-28 2.71e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.45  E-value: 2.71e-03
                          10        20
                  ....*....|....*....|....*...
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTV 28
Cdd:COG3349     4 PRVVVVGGGLAGLAAAVELAEAGFRVTL 31
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 1-77 2.90e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.84  E-value: 2.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIakstEIGSDsCSWFaGGMLAPWCEGESAEEPVVRLGQEAIGWWERHVS 77
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLI----EDEGT-CPYG-GCVLSKALLGAAEAPEIASLWADLYKRKEEVVK 71
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
3-29 3.00e-03

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 39.39  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|....*..
gi 2485719434   3 VTIIGAGVAGLVCAAEFHDQGHAVTVI 29
Cdd:COG3573     8 VIVVGAGLAGLVAAAELADAGRRVLLL 34
HI0933_like pfam03486
HI0933-like protein;
2-37 3.61e-03

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 38.72  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIGS 37
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGR 37
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 1-28 3.75e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 39.01  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*...
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTV 28
Cdd:PRK11749  141 KKVAVIGAGPAGLTAAHRLARKGYDVTI 168
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-36 4.24e-03

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 38.69  E-value: 4.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2485719434   3 VTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:PLN02172   13 VAVIGAGAAGLVAARELRREGHTVVVFEREKQVG 46
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-36 4.39e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 38.69  E-value: 4.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:COG2072     7 VDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVG 42
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-35 4.73e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 35.64  E-value: 4.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2485719434   2 RVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEI 35
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTVVERRDRL 34
PRK07208 PRK07208
hypothetical protein; Provisional
 3-36 8.32e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 37.95  E-value: 8.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2485719434   3 VTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTEIG 36
Cdd:PRK07208    7 VVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVG 40
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 1-34 9.82e-03

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 36.46  E-value: 9.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2485719434   1 MRVTIIGAGVAGLVCAAEFHDQGHAVTVIAKSTE 34
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEIGHDVIGVDIDEE 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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