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Conserved domains on  [gi|2485945133|ref|WP_278725668|]
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nitroreductase family protein [Acidaminococcus intestini]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-111 1.46e-59

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


:

Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 179.12  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   2 DFFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCAFNAPIVLMVTICRDE 81
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPRFFGAPLVIVVCYDKDE 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2485945133  82 QWVNELEkGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:cd20609    81 SWKRPYD-GKDSGDIDAAIVATHMMLAATE 109
 
Name Accession Description Interval E-value
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-111 1.46e-59

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 179.12  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   2 DFFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCAFNAPIVLMVTICRDE 81
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPRFFGAPLVIVVCYDKDE 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2485945133  82 QWVNELEkGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:cd20609    81 SWKRPYD-GKDSGDIDAAIVATHMMLAATE 109
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-111 7.78e-29

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.85  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   3 FFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT-----PCAFNAPIVLMVTI 77
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALaeanqEWVADAPVLIVVCA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2485945133  78 CRDEQWvnelEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:COG0778    81 DPDRSE----KVPERYALLDAGIAAQNLLLAARA 110
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-111 4.57e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 82.05  E-value: 4.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   7 AKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT----------------------- 63
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAAlelllvepaaalllllrrdanlk 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2485945133  64 ----PCAFNAPIVLMVTICRDEQWVNELEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:pfam00881  81 lllqDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATS 132
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
1-87 1.78e-07

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 47.27  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   1 MDFFTLAKNRYSVRKF-SERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPC--AFNAPIVL---- 73
Cdd:PRK11053    1 MDIVSVAKKRYTTKAFdPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAGnyAFNERKILdash 80

                          90
                  ....*....|....*...
gi 2485945133  74 MVTICR----DEQWVNEL 87
Cdd:PRK11053   81 VVVFCAktdmDDAYLELV 98
 
Name Accession Description Interval E-value
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-111 1.46e-59

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 179.12  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   2 DFFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCAFNAPIVLMVTICRDE 81
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPRFFGAPLVIVVCYDKDE 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2485945133  82 QWVNELEkGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:cd20609    81 SWKRPYD-GKDSGDIDAAIVATHMMLAATE 109
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-111 7.78e-29

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.85  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   3 FFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT-----PCAFNAPIVLMVTI 77
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALaeanqEWVADAPVLIVVCA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2485945133  78 CRDEQWvnelEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:COG0778    81 DPDRSE----KVPERYALLDAGIAAQNLLLAARA 110
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 8-111 5.75e-24

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 88.89  E-value: 5.75e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCA----FNAPIVlmVTICRDEqw 83
Cdd:cd02062     2 KTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNqkfiAGAPVV--IVVVADP-- 77

                          90       100
                  ....*....|....*....|....*...
gi 2485945133  84 vnelEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:cd02062    78 ----DKSRPWALEDAGAAAQNLLLAAAA 101
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-111 3.48e-23

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 87.53  E-value: 3.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   3 FFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIREltpcAFN-------APIVlmV 75
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAE----AANgqkfiaeAPVV--I 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2485945133  76 TICRDEQwVNELEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:cd02139    75 VACADPS-ESGMGCGKPYYLVDVAIAMEHLVLAATE 109
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-111 4.57e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 82.05  E-value: 4.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   7 AKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT----------------------- 63
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAAlelllvepaaalllllrrdanlk 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2485945133  64 ----PCAFNAPIVLMVTICRDEQWVNELEKGFLSGQVDAGIIGTHLMLEAWE 111
Cdd:pfam00881  81 lllqDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATS 132
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 8-111 4.52e-20

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 78.92  E-value: 4.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCAF----NAPIVlmVTICRDEQw 83
Cdd:cd20608     5 KTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAKKESPSNgwlkDAPVI--IVVCADPK- 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2485945133  84 vnelEKGFLSGQ----VDAGIIGTHLMLEAWE 111
Cdd:cd20608    82 ----DSGWLNGQnyylVDAAIAMQNLMLAATD 109
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 6-111 6.12e-20

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 78.78  E-value: 6.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   6 LAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKdAIAKIRELTpcaFNAPIVLMVTICRDEQWVN 85
Cdd:cd02136     1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGK-ARERLKKAF---FGAPVALFLTMDKVLGPWS 76

                          90       100
                  ....*....|....*....|....*.
gi 2485945133  86 elekgflsgQVDAGIIGTHLMLEAWE 111
Cdd:cd02136    77 ---------WFDLGAFLQNLMLAAHA 93
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 8-82 4.59e-17

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 71.48  E-value: 4.59e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCA---FNAPIVLMVtiCRDEQ 82
Cdd:cd02150     2 LTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHPYGkmlKEAPLAIVV--CGDPS 77
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 6-109 3.73e-16

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 69.10  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   6 LAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPCAF----NAPIVLMVTICRD- 80
Cdd:cd02151     2 LLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHGSaflkGAPAAIVVLADTEk 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 2485945133  81 -EQWVNelekgflsgqvDAGIIGTHLMLEA 109
Cdd:cd02151    82 sDTWIE-----------DASIAATYIQLAA 100
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 6-63 1.70e-15

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 68.27  E-value: 1.70e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2485945133   6 LAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT 63
Cdd:cd02143     1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAELV 58
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 8-109 6.40e-15

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 66.41  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFR-IYVLKSKDAIAKIRE-LTPC----AFNAPiVLMVTICRDE 81
Cdd:cd02138     3 AERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRfVVARRDTEAFEKLLDlLAEGnqswAKNAP-VLIVVLAKTE 81

                          90       100
                  ....*....|....*....|....*...
gi 2485945133  82 QwvNELEKGFLSGQVDAGIIGTHLMLEA 109
Cdd:cd02138    82 F--DHNGKPNRYALFDTGAAVANLALQA 107
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 8-109 2.13e-12

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 59.18  E-value: 2.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   8 KNRYSVRKF-SERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIReltPCAFNAPIV----LMVTICrdeq 82
Cdd:cd02137     5 KSRRSVRNFdPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLA---EAAYNQPQVttasAVILVL---- 77

                          90       100
                  ....*....|....*....|....*..
gi 2485945133  83 wvnelekgflsGQVDAGIIGTHLMLEA 109
Cdd:cd02137    78 -----------GDLNAGLAAMNLMLAA 93
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 8-59 1.96e-11

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 57.29  E-value: 1.96e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKI 59
Cdd:cd20610     2 KKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKI 53
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 3-61 1.59e-10

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 55.24  E-value: 1.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2485945133   3 FFTLAKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRE 61
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIRE 59
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 2-83 1.73e-10

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 54.56  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   2 DFFTLAKNRYSVRKF-SERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPcaFNAPIVL----MVT 76
Cdd:cd02149     1 NILELLNFRYATKKFdPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAW--FNQPQIKdashVVV 78


                  ....*..
gi 2485945133  77 ICRDEQW 83
Cdd:cd02149    79 FLAKKDW 85
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 7-76 2.50e-10

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 54.63  E-value: 2.50e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2485945133   7 AKNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELtpcAFN------APIVLMVT 76
Cdd:cd03370     5 IESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAA---AYGqaqvtsAPAVIVIY 77
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 8-100 6.00e-10

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 54.17  E-value: 6.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   8 KNRYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELT---PCAFNAPIVLmvTIC----RD 80
Cdd:cd02146     6 LNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAELAgnqPYVAQAPVFL--VFCadlyRH 83

                          90       100
                  ....*....|....*....|....*....
gi 2485945133  81 EQWVNELEKG---------FLSGQVDAGI 100
Cdd:cd02146    84 QKIAEEAGGKdvgldylesFLVGVVDAAL 112
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
1-87 1.78e-07

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 47.27  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   1 MDFFTLAKNRYSVRKF-SERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTPC--AFNAPIVL---- 73
Cdd:PRK11053    1 MDIVSVAKKRYTTKAFdPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAGnyAFNERKILdash 80

                          90
                  ....*....|....*...
gi 2485945133  74 MVTICR----DEQWVNEL 87
Cdd:PRK11053   81 VVVFCAktdmDDAYLELV 98
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 14-91 8.87e-07

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 44.94  E-value: 8.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133  14 RKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKireLTPC--------AFNAPIVlmVTICRDEQWVN 85
Cdd:cd02148    13 NAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKER---LVPHlsegnrekTMAAPVT--AILAYDTEFYE 87


                  ....*.
gi 2485945133  86 ELEKGF 91
Cdd:cd02148    88 HLPRLF 93
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 16-91 9.17e-07

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 45.19  E-value: 9.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133  16 FSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIReltPCAF--------NAPIVlmVTICRDEQWVNEL 87
Cdd:PRK05365   22 WLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLR---PALSegnlaktlAAPVT--AIVAYDTEFHEHL 96


                  ....
gi 2485945133  88 EKGF 91
Cdd:PRK05365   97 PKLF 100
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 4-81 2.17e-06

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 43.75  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133   4 FTLAKNRYSVRKFSERS-VEPEKLEKVLEAARVAPTAHNYQPFRIYVL----------------------KSKDAIAKIR 60
Cdd:cd02135     1 LELIKTRRSIRKFKLTGaPPEEQLEELLEAAMWAPNHGKLEPWRFIVVtgegrerlaellaaaaaarapgADPEKLEKAR 80

                          90       100
                  ....*....|....*....|.
gi 2485945133  61 ELtpcAFNAPIVLMVTICRDE 81
Cdd:cd02135    81 EK---ALRAPVVIAVVAKPDE 98
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 10-62 1.42e-05

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 41.96  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2485945133  10 RYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIREL 62
Cdd:cd02145     7 RRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHEL 59
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
12-109 2.61e-04

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 38.42  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485945133  12 SVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKDAIAKIRELTP--------------CA-FNApivlMVT 76
Cdd:PRK10765   13 SIRHFTDEPISEAQREAIINAARAASSSSFLQCSSIIRITDKALREALVELTGgqkyvaqaaefwvfCAdFNR----HLQ 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2485945133  77 ICRDEQ--WVNELekgfLSGQVDAGIIGTHLMLEA 109
Cdd:PRK10765   89 ICPDAQlgLAEQL----LIGAVDTAIMAQNALLAA 119
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 10-54 7.85e-04

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 37.30  E-value: 7.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2485945133  10 RYSVRKFSERSVEPEKLEKVLEAARVAPTAHNYQPFRIYVLKSKD 54
Cdd:PRK13294  260 RRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAA 304
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 23-47 1.91e-03

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 35.73  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*
gi 2485945133  23 PEKLEKVLEAARVAPTAHNYQPFRI 47
Cdd:pfam14512 156 PEWFKEGMEAARLAPSAMNQQPWRF 180
Frm2-like cd02140
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-50 5.64e-03

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380317  Cd Length: 192  Bit Score: 34.59  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2485945133   3 FFTLAKNRYSVRKF-SERSVEPEKLEK-VLEAARVAPTAHNYQPFRIYVL 50
Cdd:cd02140     1 FLEAAKARRTIYALgKNSPVSDEEIEEiVKEAVKHVPSSFNSQSSRAVIL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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