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Concise Results
Standard Results
Full Results
2-oxoglutarate dehydrogenase E1 component [Glaesserella parasuis]
Protein Classification
2-oxoglutarate dehydrogenase subunit E1 ( domain architecture ID 11484076 )
2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-934
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1766.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 2 QHKNFDD W IATTA L G GAN QS Y V EE I YEQYL E DPDSVD AS W Q A V F AQ LP KAT q VEQP HS S VR DY FRRLA REN R SEA vtvid 81
Cdd:PRK09404 1 MNSAMKA W LDSSF L F GAN AA Y I EE L YEQYL K DPDSVD EE W R A F F DG LP GVA - PDVA HS A VR ES FRRLA KPA R VSS ----- 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 82 p EA S AKL VKVLQ F INAYRFRGHL E A K LDPL N yy R WK TSQ VPELD YRYH G FSDK DL EE TF TI G RYVYN K D T MK L G E LA EAL 161
Cdd:PRK09404 75 - AV S DPQ VKVLQ L INAYRFRGHL A A N LDPL G -- L WK RPD VPELD PAFY G LTEA DL DR TF NT G SLALG K E T AT L R E II EAL 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 162 K E TYCGSIG L E F MHI Q D M E QKN WLQ AK IES VLNK pl F TK E Q K VNL L TE LTAA D G L ER Y L GA KF P G A KRFSLEG SDAF IPM 241
Cdd:PRK09404 152 K K TYCGSIG V E Y MHI S D P E ERR WLQ QR IES GRPS -- F SA E E K KAI L ER LTAA E G F ER F L HT KF V G Q KRFSLEG GESL IPM 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 242 MK EIIR H AG RQ G MENV V M GMAHRGRLN M LVNVLGK K P AE LF D EF A GKH -- ADDNRT GDVKYH Q GFSSD FDV DG KH VHL A L 319
Cdd:PRK09404 230 LD EIIR R AG KL G VKEI V I GMAHRGRLN V LVNVLGK P P RD LF A EF E GKH gp DEVLGS GDVKYH L GFSSD RET DG GE VHL S L 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 320 AFNPSHLEIV S PVV I GSVRARQ T R IH D - TEH KKVL A I TV HGD S A V AGQGVV Q ETLN M S NA RGY KV GGTI R IVINNQIGFT 398
Cdd:PRK09404 310 AFNPSHLEIV N PVV E GSVRARQ D R RG D g QDR KKVL P I LI HGD A A F AGQGVV A ETLN L S QL RGY RT GGTI H IVINNQIGFT 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 399 TS N P N D t RST E YCTD I AKM I QAPI I HVNGDDPEAV A FA A R M A V EYR CL FK R D IF IDL IS YRRHGHNE A DEP LA TQP M MY G 478
Cdd:PRK09404 390 TS P P D D - RST P YCTD V AKM V QAPI F HVNGDDPEAV V FA T R L A L EYR QK FK K D VV IDL VC YRRHGHNE G DEP SF TQP L MY K 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 479 L IKKHPT P R KV YAD R L I AEGVIT GDDEI EM M N L YRDALD N G DR VV P EWR EM D TASM DW LQ YL NY EW TS P YESKF P EA R FL 558
Cdd:PRK09404 469 K IKKHPT T R EL YAD K L V AEGVIT EEEAD EM V N E YRDALD A G FE VV K EWR PA D WLAG DW SP YL GH EW DD P VDTGV P LE R LK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 559 E I A KRVCEY PE ALRP HP R V E KI YN DRREM YQ G N K LL DWGMAE TM A Y A T LLD D G TH VRLSG E D A GRGTF F HRHAV V H N Q ND 638
Cdd:PRK09404 549 E L A EKLTTV PE GFKV HP K V K KI LE DRREM AE G E K PI DWGMAE AL A F A S LLD E G YP VRLSG Q D S GRGTF S HRHAV L H D Q KT 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 639 G TG Y V PL T HL HAN Q GR FEV W DS V LSEEAVL A FEYGY A T TD P K TL T IWEAQFGDFANGAQ I VIDQFISSGEQKWGR MC GLV 718
Cdd:PRK09404 629 G ET Y I PL N HL SEG Q AS FEV Y DS P LSEEAVL G FEYGY S T AE P N TL V IWEAQFGDFANGAQ V VIDQFISSGEQKWGR LS GLV 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 719 MLLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC I P S TPAQ VY H M LRRQA I R KM R R PL IAIS PKSLLRHPLAVS T L D EL I 798
Cdd:PRK09404 709 MLLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQA L R PF R K PL VVMT PKSLLRHPLAVS S L E EL A 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 799 N G E F KT VIG EL D N LDP AQ VKRVVLCSGKVYYDLLE E RR Q R VKT DVAI I RIEQLYP Y PHE DVKKA L MP Y AHVTDY VWCQEE 878
Cdd:PRK09404 789 E G S F QP VIG DI D E LDP KK VKRVVLCSGKVYYDLLE A RR K R GID DVAI V RIEQLYP F PHE ELAAE L AK Y PNAKEV VWCQEE 868
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490852290 879 P L NQG V WY CSK H NF E ASI PE NAT L K YAGRPASASPAVGYMSLH T KQQ TQ LV DE AL S 934
Cdd:PRK09404 869 P K NQG A WY FIQ H HL E EVL PE GQK L R YAGRPASASPAVGYMSLH K KQQ EA LV ED AL G 924
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-934
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1766.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 2 QHKNFDD W IATTA L G GAN QS Y V EE I YEQYL E DPDSVD AS W Q A V F AQ LP KAT q VEQP HS S VR DY FRRLA REN R SEA vtvid 81
Cdd:PRK09404 1 MNSAMKA W LDSSF L F GAN AA Y I EE L YEQYL K DPDSVD EE W R A F F DG LP GVA - PDVA HS A VR ES FRRLA KPA R VSS ----- 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 82 p EA S AKL VKVLQ F INAYRFRGHL E A K LDPL N yy R WK TSQ VPELD YRYH G FSDK DL EE TF TI G RYVYN K D T MK L G E LA EAL 161
Cdd:PRK09404 75 - AV S DPQ VKVLQ L INAYRFRGHL A A N LDPL G -- L WK RPD VPELD PAFY G LTEA DL DR TF NT G SLALG K E T AT L R E II EAL 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 162 K E TYCGSIG L E F MHI Q D M E QKN WLQ AK IES VLNK pl F TK E Q K VNL L TE LTAA D G L ER Y L GA KF P G A KRFSLEG SDAF IPM 241
Cdd:PRK09404 152 K K TYCGSIG V E Y MHI S D P E ERR WLQ QR IES GRPS -- F SA E E K KAI L ER LTAA E G F ER F L HT KF V G Q KRFSLEG GESL IPM 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 242 MK EIIR H AG RQ G MENV V M GMAHRGRLN M LVNVLGK K P AE LF D EF A GKH -- ADDNRT GDVKYH Q GFSSD FDV DG KH VHL A L 319
Cdd:PRK09404 230 LD EIIR R AG KL G VKEI V I GMAHRGRLN V LVNVLGK P P RD LF A EF E GKH gp DEVLGS GDVKYH L GFSSD RET DG GE VHL S L 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 320 AFNPSHLEIV S PVV I GSVRARQ T R IH D - TEH KKVL A I TV HGD S A V AGQGVV Q ETLN M S NA RGY KV GGTI R IVINNQIGFT 398
Cdd:PRK09404 310 AFNPSHLEIV N PVV E GSVRARQ D R RG D g QDR KKVL P I LI HGD A A F AGQGVV A ETLN L S QL RGY RT GGTI H IVINNQIGFT 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 399 TS N P N D t RST E YCTD I AKM I QAPI I HVNGDDPEAV A FA A R M A V EYR CL FK R D IF IDL IS YRRHGHNE A DEP LA TQP M MY G 478
Cdd:PRK09404 390 TS P P D D - RST P YCTD V AKM V QAPI F HVNGDDPEAV V FA T R L A L EYR QK FK K D VV IDL VC YRRHGHNE G DEP SF TQP L MY K 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 479 L IKKHPT P R KV YAD R L I AEGVIT GDDEI EM M N L YRDALD N G DR VV P EWR EM D TASM DW LQ YL NY EW TS P YESKF P EA R FL 558
Cdd:PRK09404 469 K IKKHPT T R EL YAD K L V AEGVIT EEEAD EM V N E YRDALD A G FE VV K EWR PA D WLAG DW SP YL GH EW DD P VDTGV P LE R LK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 559 E I A KRVCEY PE ALRP HP R V E KI YN DRREM YQ G N K LL DWGMAE TM A Y A T LLD D G TH VRLSG E D A GRGTF F HRHAV V H N Q ND 638
Cdd:PRK09404 549 E L A EKLTTV PE GFKV HP K V K KI LE DRREM AE G E K PI DWGMAE AL A F A S LLD E G YP VRLSG Q D S GRGTF S HRHAV L H D Q KT 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 639 G TG Y V PL T HL HAN Q GR FEV W DS V LSEEAVL A FEYGY A T TD P K TL T IWEAQFGDFANGAQ I VIDQFISSGEQKWGR MC GLV 718
Cdd:PRK09404 629 G ET Y I PL N HL SEG Q AS FEV Y DS P LSEEAVL G FEYGY S T AE P N TL V IWEAQFGDFANGAQ V VIDQFISSGEQKWGR LS GLV 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 719 MLLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC I P S TPAQ VY H M LRRQA I R KM R R PL IAIS PKSLLRHPLAVS T L D EL I 798
Cdd:PRK09404 709 MLLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQA L R PF R K PL VVMT PKSLLRHPLAVS S L E EL A 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 799 N G E F KT VIG EL D N LDP AQ VKRVVLCSGKVYYDLLE E RR Q R VKT DVAI I RIEQLYP Y PHE DVKKA L MP Y AHVTDY VWCQEE 878
Cdd:PRK09404 789 E G S F QP VIG DI D E LDP KK VKRVVLCSGKVYYDLLE A RR K R GID DVAI V RIEQLYP F PHE ELAAE L AK Y PNAKEV VWCQEE 868
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490852290 879 P L NQG V WY CSK H NF E ASI PE NAT L K YAGRPASASPAVGYMSLH T KQQ TQ LV DE AL S 934
Cdd:PRK09404 869 P K NQG A WY FIQ H HL E EVL PE GQK L R YAGRPASASPAVGYMSLH K KQQ EA LV ED AL G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
1-935
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1764.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 1 M QH K NF D D wia TTA L G GAN QS Y V EE I YEQYLEDPDSVD A SW Q A V F AQ LP K - ATQVEQP HS SV R DY FR R LA RENRSE A VT - 78
Cdd:COG0567 1 M LM K AM D R --- SSF L S GAN AA Y I EE L YEQYLEDPDSVD P SW R A F F DG LP D v PGARDFA HS PI R EE FR K LA KNGAGA A AS a 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 79 VI DPEA SA K L V K VLQ F INAYR F RGHL E AKLDPL N yy RWKTSQ VPELD YRYH G FSDK DL EET F TI G RYV y NKD T MK L G E LA 158
Cdd:COG0567 78 AA DPEA AR K Q V R VLQ L INAYR V RGHL F AKLDPL G -- LRERPY VPELD PAFY G LTEA DL DTV F NT G SLL - GLE T AT L R E II 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 159 E ALKETYCGSIG L E F MHI Q D M E Q K N W L Q AKI ES VL N K P L F TK E Q K VNL L TE LTAA D G L E RY L GA K FP G A KRFSLEG SDAF 238
Cdd:COG0567 155 A ALKETYCGSIG V E Y MHI S D P E E K R W I Q ERL ES TR N R P S F SA E E K KRI L EK LTAA E G F E KF L HT K YV G Q KRFSLEG GESL 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 239 IP MMK E I I RH AG RQ G MENV V M GMAHRGRLN M LVN V LGK K P AEL F D EF A GK H A D D - NRT GDVKYH Q GFSSD FDVD G KH VHL 317
Cdd:COG0567 235 IP ALD E L I ER AG EL G VKEI V I GMAHRGRLN V LVN I LGK P P RDI F S EF E GK S A E D v LGS GDVKYH L GFSSD VETP G GK VHL 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 318 A LAFNPSHLEIV S PVV I GSVRARQ T R IH DT EHK KVL A I TV HGD S A V AGQGVV Q ETLNMS NA RGY KV GGTI R IVINNQIGF 397
Cdd:COG0567 315 S LAFNPSHLEIV N PVV E GSVRARQ D R RG DT DRD KVL P I LI HGD A A F AGQGVV Y ETLNMS QL RGY RT GGTI H IVINNQIGF 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 398 TTS n P N D T RS TE YCTD I AKM I QAPI I HVNGDDPEAV A F A AR M A VE YR CL FK R D IF IDL IS YRRHGHNE A DEP LA TQP M MY 477
Cdd:COG0567 395 TTS - P R D A RS ST YCTD V AKM V QAPI F HVNGDDPEAV V F V AR L A LD YR QK FK K D VV IDL VC YRRHGHNE G DEP AF TQP L MY 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 478 GL IKKHPT P R KV YAD R L I AEGVIT GDDEI EM MNL YR D ALD N G DR VV P E WREMDTASM -- DW -- LQY L NYE W TS P YESKF P 553
Cdd:COG0567 474 KK IKKHPT T R EI YAD K L V AEGVIT AEEAD EM VDE YR A ALD E G FE VV K E YKPNKADWL eg DW sp YRR L GED W DD P VDTGV P 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 554 EARFL E IAKRVCEY PE ALRP HP R VEKI YN DRR E M YQ G N K L LDWGMAE TM AYA T LLD D G TH VRLSG E D A GRGTF F HRHAV V 633
Cdd:COG0567 554 LEKLK E LGEKLTTL PE GFKL HP K VEKI LE DRR K M AE G E K P LDWGMAE AL AYA S LLD E G YP VRLSG Q D S GRGTF S HRHAV L 633
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 634 H N Q ND G TG YVPL T HL HAN Q G RFEV WD S V LSEEAVL A FEYGYA TTD P K TL T IWEAQFGDFANGAQ I VIDQFISSGE Q KWGR 713
Cdd:COG0567 634 H D Q KT G ET YVPL N HL SEG Q A RFEV YN S L LSEEAVL G FEYGYA LAE P N TL V IWEAQFGDFANGAQ V VIDQFISSGE S KWGR 713
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 714 MC GLVMLLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC I P S TPAQ VY H M LRRQ AI R KM R R PLI AIS PKSLLRH P LAVS T 793
Cdd:COG0567 714 LS GLVMLLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQ MK R PF R K PLI VMT PKSLLRH K LAVS S 793
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 794 L D EL IN G E F KT VI GEL D N LDP AQ VKRVVLCSGKVYYDLLEERR Q R VKT DVAI I RIEQLYP Y P H E DVKKA L MP Y AHVTDY V 873
Cdd:COG0567 794 L E EL AE G S F QE VI DDT D E LDP KK VKRVVLCSGKVYYDLLEERR E R GRD DVAI V RIEQLYP F P E E ELAAE L AK Y PNAKEV V 873
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2490852290 874 WCQEEP L N Q G V WY CSK H NF E ASI P ENAT L K YAGRPASASPA V GYMS L H TKQ Q TQ LV D EAL SV 935
Cdd:COG0567 874 WCQEEP K N M G A WY FIQ H RL E EVL P KGQR L R YAGRPASASPA T GYMS V H KAE Q KA LV E EAL GI 935
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
14-933
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1597.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 14 A L G GANQSY V EE I YE Q YL E DPDSVDASW QAV F A QLP K - ATQVE Q P HS SV R D YFRRLA RENRSEA VT VI DP EASAKL VKVL 92
Cdd:TIGR00239 1 Y L S GANQSY I EE L YE D YL T DPDSVDASW RST F D QLP G p GPAPD Q F HS PT R S YFRRLA KDASRGS VT IS DP DTNVSQ VKVL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 93 Q F I N AYRFRGHL E A K LDPL N yy RWKTSQ VPELD YRYH G FSDK DL E ETF T IG RY V YN KD - TMKL G -- EL AE ALK E TYCGSI 169
Cdd:TIGR00239 81 Q L I R AYRFRGHL H A N LDPL G -- LKQQDK VPELD LSFY G LTEA DL Q ETF N IG SF V SG KD a TMKL S nl EL LQ ALK Q TYCGSI 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 170 G L E F MHI QDM E Q K N WLQ AK IES v LNKPL F TK E Q K VNL L TE LTAA D G L ER Y LGAKFPGAKRFSLEG S DA FI PM M KEIIRH A 249
Cdd:TIGR00239 159 G A E Y MHI TST E E K R WLQ QR IES - GERAQ F NS E E K KRF L SR LTAA E G F ER F LGAKFPGAKRFSLEG L DA LV PM L KEIIRH S 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 250 GRQ G MEN VV M GMAHRGRLN M LVNVLGK K P AEL F D EFAGKH ADD -- NR TGDVKYH Q G - FSSDF DV DGK H VHLALAFNPSHL 326
Cdd:TIGR00239 238 VNS G TRD VV L GMAHRGRLN V LVNVLGK P P EDI F S EFAGKH KSH lp DG TGDVKYH M G r FSSDF TT DGK L VHLALAFNPSHL 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 327 EIVSPVVIGS V RAR QT R IH D - T E HK KVLAI TV HGD S A V AGQGVVQETLNMS NA RGY K VGGTI R I V INNQIGFTT s NP N D T 405
Cdd:TIGR00239 318 EIVSPVVIGS T RAR LD R LN D s P E ST KVLAI LI HGD A A F AGQGVVQETLNMS KL RGY S VGGTI H I I INNQIGFTT - NP L D A 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 406 RST E YC T D I AKMIQAPI I HVN G DDPEAVAFA A R M AVEYR CL FKRD I FIDL IS YRRHGHNEADEP L ATQP M MY GL IKKHPT 485
Cdd:TIGR00239 397 RST P YC S D L AKMIQAPI F HVN A DDPEAVAFA T R L AVEYR NT FKRD V FIDL VG YRRHGHNEADEP S ATQP L MY QK IKKHPT 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 486 PRKVYAD R L IA EGV I T GD D EI EM M NLYRDAL DNG D R VVP E WREM D TAS MD W LQY LN Y EW TSP Y ES K FPEA R FL E I AKR VC 565
Cdd:TIGR00239 477 PRKVYAD K L VS EGV A T EE D VT EM V NLYRDAL EAA D C VVP S WREM N TAS FT W SPE LN H EW DEE Y PN K VEMK R LQ E L AKR IS 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 566 E Y PE ALRP H P RV E KIY N DR - RE M YQ G N KL L DWG M AE TM A Y ATL L DDG TH VRLSGED AG RGTFF H RHAV V H N Q ND G TG Y V P 644
Cdd:TIGR00239 557 E V PE GVEM H S RV A KIY F DR t KA M AA G E KL F DWG G AE NL A F ATL V DDG IP VRLSGED SE RGTFF Q RHAV L H D Q SN G ST Y T P 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 645 L T HLH AN QG R F E VW D SVLSEE A VL A FEYGYATT D P K TL T IWEAQFGDFANGAQ I VIDQFISSGEQKWG R M C GLVMLLPHG 724
Cdd:TIGR00239 637 L Q HLH NG QG A F R VW N SVLSEE S VL G FEYGYATT S P R TL V IWEAQFGDFANGAQ V VIDQFISSGEQKWG Q M S GLVMLLPHG 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 725 YEGQGPEHSS A RLER Y LQL C AEQNMQVC I P S TPAQV Y H M LRRQA I R K MRRPL IAI SPKSLLRHPLAVS T L D EL IN G E F KT 804
Cdd:TIGR00239 717 YEGQGPEHSS G RLER F LQL A AEQNMQVC V P T TPAQV F H I LRRQA L R G MRRPL VVM SPKSLLRHPLAVS S L E EL AE G T F QP 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 805 VIGE LDN ---- LDP AQ VKR V VLCSGKVYYDL L E E RR QRVKT DVAI I RIEQLYP Y PH ED VK KA L MP Y AHVTDY VWCQEEPL 880
Cdd:TIGR00239 797 VIGE IEE sgls LDP EG VKR L VLCSGKVYYDL H E Q RR KNGQK DVAI V RIEQLYP F PH KA VK EV L QQ Y PNLKEI VWCQEEPL 876
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 2490852290 881 N Q G V WY C S KHNFEAS IPE NATLK YAGRPASASPAVGYMSLH T KQQ TQ L VDE AL 933
Cdd:TIGR00239 877 N M G A WY Y S QPHLREV IPE GVSVR YAGRPASASPAVGYMSLH Q KQQ QD L LND AL 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
216-477
8.88e-159
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 466.24
E-value: 8.88e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 216 L E RY L GA KFPG A KRF S LEG SDAF IP MMK E I I RH A GRQ G M E N VV M GMAHRGRLN M L V NVLGK KPAEL F D EF A GK HA --- DD 292
Cdd:cd02016 1 F E QF L AT KFPG Q KRF G LEG AESL IP ALD E L I DR A AEL G V E E VV I GMAHRGRLN V L A NVLGK PLEQI F S EF E GK SE fpe DD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 293 NRT GDVKYH Q G F SSD FDVD - GK H VHL A LA F NPSHLE I V S PVV I G SV RA R Q TRIH D T E HK KVL A I TV HGD S A V AGQGVV Q E 371
Cdd:cd02016 81 EGS GDVKYH L G Y SSD RKTP s GK K VHL S LA P NPSHLE A V N PVV M G KT RA K Q DYRG D G E RD KVL P I LI HGD A A F AGQGVV Y E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 372 TLN M SN AR GY KV GGTI R IV I NNQIGFTT s N P N D T RS TE YCTD I AKMI Q API I HVNGDDPEAV AF A A R M A V EYR CL FK R D I 451
Cdd:cd02016 161 TLN L SN LP GY TT GGTI H IV V NNQIGFTT - D P R D S RS SP YCTD V AKMI G API F HVNGDDPEAV VR A T R L A L EYR QK FK K D V 239
250 260
....*....|....*....|....*.
gi 2490852290 452 F IDL IS YRRHGHNE A DEP LA TQP M MY 477
Cdd:cd02016 240 V IDL VC YRRHGHNE L DEP SF TQP L MY 265
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
791-933
1.32e-70
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 230.02
E-value: 1.32e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 791 V S T L D E LIN G - E F KT VI GELDN L - DP AQ VKRVVLCSGKVYYDLL E ER RQ R VK - T DVAI I RIEQLYP Y P HEDV K KA L MP Y A 867
Cdd:pfam16870 1 R S S L E E FTP G t H F QR VI PDPEP L v DP EK VKRVVLCSGKVYYDLL K ER EE R GG i K DVAI V RIEQLYP F P FDLL K EE L DK Y P 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2490852290 868 HVTDY VWCQEEP L NQG V W YCSKHNF E ASIP E - NAT L K YAGRP A SASPA V G YM S L H TKQ Q TQ L V D E A L 933
Cdd:pfam16870 81 NAAEI VWCQEEP K NQG A W SFVQPRL E TVLN E t GHR L R YAGRP P SASPA T G SK S V H LAE Q EA L L D D A F 147
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
656-786
2.25e-29
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 113.74
E-value: 2.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 656 EVW D SVLS E E A VLA F EY G Y A TTD pkt L TIWEAQ F GD F ANG A QIV I DQFIS SG E qkwgr MCGLVMLLPH G YE G Q - GP E H S S 734
Cdd:smart00861 16 LAI D TGIA E Q A MVG F AA G L A LHG --- L RPVVEI F FT F FDR A KDQ I RSAGA SG N ----- VPVVFRHDGG G GV G E d GP T H H S 87
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2490852290 735 ARL E - RYLQLC aeq NMQ V CI PS T PA QVYHM LR R q AIR KMRRPL I AISP KSL L R 786
Cdd:smart00861 88 IED E a LLRAIP --- GLK V VA PS D PA EAKGL LR A - AIR DDGPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-934
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1766.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 2 QHKNFDD W IATTA L G GAN QS Y V EE I YEQYL E DPDSVD AS W Q A V F AQ LP KAT q VEQP HS S VR DY FRRLA REN R SEA vtvid 81
Cdd:PRK09404 1 MNSAMKA W LDSSF L F GAN AA Y I EE L YEQYL K DPDSVD EE W R A F F DG LP GVA - PDVA HS A VR ES FRRLA KPA R VSS ----- 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 82 p EA S AKL VKVLQ F INAYRFRGHL E A K LDPL N yy R WK TSQ VPELD YRYH G FSDK DL EE TF TI G RYVYN K D T MK L G E LA EAL 161
Cdd:PRK09404 75 - AV S DPQ VKVLQ L INAYRFRGHL A A N LDPL G -- L WK RPD VPELD PAFY G LTEA DL DR TF NT G SLALG K E T AT L R E II EAL 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 162 K E TYCGSIG L E F MHI Q D M E QKN WLQ AK IES VLNK pl F TK E Q K VNL L TE LTAA D G L ER Y L GA KF P G A KRFSLEG SDAF IPM 241
Cdd:PRK09404 152 K K TYCGSIG V E Y MHI S D P E ERR WLQ QR IES GRPS -- F SA E E K KAI L ER LTAA E G F ER F L HT KF V G Q KRFSLEG GESL IPM 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 242 MK EIIR H AG RQ G MENV V M GMAHRGRLN M LVNVLGK K P AE LF D EF A GKH -- ADDNRT GDVKYH Q GFSSD FDV DG KH VHL A L 319
Cdd:PRK09404 230 LD EIIR R AG KL G VKEI V I GMAHRGRLN V LVNVLGK P P RD LF A EF E GKH gp DEVLGS GDVKYH L GFSSD RET DG GE VHL S L 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 320 AFNPSHLEIV S PVV I GSVRARQ T R IH D - TEH KKVL A I TV HGD S A V AGQGVV Q ETLN M S NA RGY KV GGTI R IVINNQIGFT 398
Cdd:PRK09404 310 AFNPSHLEIV N PVV E GSVRARQ D R RG D g QDR KKVL P I LI HGD A A F AGQGVV A ETLN L S QL RGY RT GGTI H IVINNQIGFT 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 399 TS N P N D t RST E YCTD I AKM I QAPI I HVNGDDPEAV A FA A R M A V EYR CL FK R D IF IDL IS YRRHGHNE A DEP LA TQP M MY G 478
Cdd:PRK09404 390 TS P P D D - RST P YCTD V AKM V QAPI F HVNGDDPEAV V FA T R L A L EYR QK FK K D VV IDL VC YRRHGHNE G DEP SF TQP L MY K 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 479 L IKKHPT P R KV YAD R L I AEGVIT GDDEI EM M N L YRDALD N G DR VV P EWR EM D TASM DW LQ YL NY EW TS P YESKF P EA R FL 558
Cdd:PRK09404 469 K IKKHPT T R EL YAD K L V AEGVIT EEEAD EM V N E YRDALD A G FE VV K EWR PA D WLAG DW SP YL GH EW DD P VDTGV P LE R LK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 559 E I A KRVCEY PE ALRP HP R V E KI YN DRREM YQ G N K LL DWGMAE TM A Y A T LLD D G TH VRLSG E D A GRGTF F HRHAV V H N Q ND 638
Cdd:PRK09404 549 E L A EKLTTV PE GFKV HP K V K KI LE DRREM AE G E K PI DWGMAE AL A F A S LLD E G YP VRLSG Q D S GRGTF S HRHAV L H D Q KT 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 639 G TG Y V PL T HL HAN Q GR FEV W DS V LSEEAVL A FEYGY A T TD P K TL T IWEAQFGDFANGAQ I VIDQFISSGEQKWGR MC GLV 718
Cdd:PRK09404 629 G ET Y I PL N HL SEG Q AS FEV Y DS P LSEEAVL G FEYGY S T AE P N TL V IWEAQFGDFANGAQ V VIDQFISSGEQKWGR LS GLV 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 719 MLLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC I P S TPAQ VY H M LRRQA I R KM R R PL IAIS PKSLLRHPLAVS T L D EL I 798
Cdd:PRK09404 709 MLLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQA L R PF R K PL VVMT PKSLLRHPLAVS S L E EL A 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 799 N G E F KT VIG EL D N LDP AQ VKRVVLCSGKVYYDLLE E RR Q R VKT DVAI I RIEQLYP Y PHE DVKKA L MP Y AHVTDY VWCQEE 878
Cdd:PRK09404 789 E G S F QP VIG DI D E LDP KK VKRVVLCSGKVYYDLLE A RR K R GID DVAI V RIEQLYP F PHE ELAAE L AK Y PNAKEV VWCQEE 868
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 2490852290 879 P L NQG V WY CSK H NF E ASI PE NAT L K YAGRPASASPAVGYMSLH T KQQ TQ LV DE AL S 934
Cdd:PRK09404 869 P K NQG A WY FIQ H HL E EVL PE GQK L R YAGRPASASPAVGYMSLH K KQQ EA LV ED AL G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
1-935
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1764.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 1 M QH K NF D D wia TTA L G GAN QS Y V EE I YEQYLEDPDSVD A SW Q A V F AQ LP K - ATQVEQP HS SV R DY FR R LA RENRSE A VT - 78
Cdd:COG0567 1 M LM K AM D R --- SSF L S GAN AA Y I EE L YEQYLEDPDSVD P SW R A F F DG LP D v PGARDFA HS PI R EE FR K LA KNGAGA A AS a 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 79 VI DPEA SA K L V K VLQ F INAYR F RGHL E AKLDPL N yy RWKTSQ VPELD YRYH G FSDK DL EET F TI G RYV y NKD T MK L G E LA 158
Cdd:COG0567 78 AA DPEA AR K Q V R VLQ L INAYR V RGHL F AKLDPL G -- LRERPY VPELD PAFY G LTEA DL DTV F NT G SLL - GLE T AT L R E II 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 159 E ALKETYCGSIG L E F MHI Q D M E Q K N W L Q AKI ES VL N K P L F TK E Q K VNL L TE LTAA D G L E RY L GA K FP G A KRFSLEG SDAF 238
Cdd:COG0567 155 A ALKETYCGSIG V E Y MHI S D P E E K R W I Q ERL ES TR N R P S F SA E E K KRI L EK LTAA E G F E KF L HT K YV G Q KRFSLEG GESL 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 239 IP MMK E I I RH AG RQ G MENV V M GMAHRGRLN M LVN V LGK K P AEL F D EF A GK H A D D - NRT GDVKYH Q GFSSD FDVD G KH VHL 317
Cdd:COG0567 235 IP ALD E L I ER AG EL G VKEI V I GMAHRGRLN V LVN I LGK P P RDI F S EF E GK S A E D v LGS GDVKYH L GFSSD VETP G GK VHL 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 318 A LAFNPSHLEIV S PVV I GSVRARQ T R IH DT EHK KVL A I TV HGD S A V AGQGVV Q ETLNMS NA RGY KV GGTI R IVINNQIGF 397
Cdd:COG0567 315 S LAFNPSHLEIV N PVV E GSVRARQ D R RG DT DRD KVL P I LI HGD A A F AGQGVV Y ETLNMS QL RGY RT GGTI H IVINNQIGF 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 398 TTS n P N D T RS TE YCTD I AKM I QAPI I HVNGDDPEAV A F A AR M A VE YR CL FK R D IF IDL IS YRRHGHNE A DEP LA TQP M MY 477
Cdd:COG0567 395 TTS - P R D A RS ST YCTD V AKM V QAPI F HVNGDDPEAV V F V AR L A LD YR QK FK K D VV IDL VC YRRHGHNE G DEP AF TQP L MY 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 478 GL IKKHPT P R KV YAD R L I AEGVIT GDDEI EM MNL YR D ALD N G DR VV P E WREMDTASM -- DW -- LQY L NYE W TS P YESKF P 553
Cdd:COG0567 474 KK IKKHPT T R EI YAD K L V AEGVIT AEEAD EM VDE YR A ALD E G FE VV K E YKPNKADWL eg DW sp YRR L GED W DD P VDTGV P 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 554 EARFL E IAKRVCEY PE ALRP HP R VEKI YN DRR E M YQ G N K L LDWGMAE TM AYA T LLD D G TH VRLSG E D A GRGTF F HRHAV V 633
Cdd:COG0567 554 LEKLK E LGEKLTTL PE GFKL HP K VEKI LE DRR K M AE G E K P LDWGMAE AL AYA S LLD E G YP VRLSG Q D S GRGTF S HRHAV L 633
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 634 H N Q ND G TG YVPL T HL HAN Q G RFEV WD S V LSEEAVL A FEYGYA TTD P K TL T IWEAQFGDFANGAQ I VIDQFISSGE Q KWGR 713
Cdd:COG0567 634 H D Q KT G ET YVPL N HL SEG Q A RFEV YN S L LSEEAVL G FEYGYA LAE P N TL V IWEAQFGDFANGAQ V VIDQFISSGE S KWGR 713
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 714 MC GLVMLLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC I P S TPAQ VY H M LRRQ AI R KM R R PLI AIS PKSLLRH P LAVS T 793
Cdd:COG0567 714 LS GLVMLLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQ MK R PF R K PLI VMT PKSLLRH K LAVS S 793
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 794 L D EL IN G E F KT VI GEL D N LDP AQ VKRVVLCSGKVYYDLLEERR Q R VKT DVAI I RIEQLYP Y P H E DVKKA L MP Y AHVTDY V 873
Cdd:COG0567 794 L E EL AE G S F QE VI DDT D E LDP KK VKRVVLCSGKVYYDLLEERR E R GRD DVAI V RIEQLYP F P E E ELAAE L AK Y PNAKEV V 873
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2490852290 874 WCQEEP L N Q G V WY CSK H NF E ASI P ENAT L K YAGRPASASPA V GYMS L H TKQ Q TQ LV D EAL SV 935
Cdd:COG0567 874 WCQEEP K N M G A WY FIQ H RL E EVL P KGQR L R YAGRPASASPA T GYMS V H KAE Q KA LV E EAL GI 935
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
14-933
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1597.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 14 A L G GANQSY V EE I YE Q YL E DPDSVDASW QAV F A QLP K - ATQVE Q P HS SV R D YFRRLA RENRSEA VT VI DP EASAKL VKVL 92
Cdd:TIGR00239 1 Y L S GANQSY I EE L YE D YL T DPDSVDASW RST F D QLP G p GPAPD Q F HS PT R S YFRRLA KDASRGS VT IS DP DTNVSQ VKVL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 93 Q F I N AYRFRGHL E A K LDPL N yy RWKTSQ VPELD YRYH G FSDK DL E ETF T IG RY V YN KD - TMKL G -- EL AE ALK E TYCGSI 169
Cdd:TIGR00239 81 Q L I R AYRFRGHL H A N LDPL G -- LKQQDK VPELD LSFY G LTEA DL Q ETF N IG SF V SG KD a TMKL S nl EL LQ ALK Q TYCGSI 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 170 G L E F MHI QDM E Q K N WLQ AK IES v LNKPL F TK E Q K VNL L TE LTAA D G L ER Y LGAKFPGAKRFSLEG S DA FI PM M KEIIRH A 249
Cdd:TIGR00239 159 G A E Y MHI TST E E K R WLQ QR IES - GERAQ F NS E E K KRF L SR LTAA E G F ER F LGAKFPGAKRFSLEG L DA LV PM L KEIIRH S 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 250 GRQ G MEN VV M GMAHRGRLN M LVNVLGK K P AEL F D EFAGKH ADD -- NR TGDVKYH Q G - FSSDF DV DGK H VHLALAFNPSHL 326
Cdd:TIGR00239 238 VNS G TRD VV L GMAHRGRLN V LVNVLGK P P EDI F S EFAGKH KSH lp DG TGDVKYH M G r FSSDF TT DGK L VHLALAFNPSHL 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 327 EIVSPVVIGS V RAR QT R IH D - T E HK KVLAI TV HGD S A V AGQGVVQETLNMS NA RGY K VGGTI R I V INNQIGFTT s NP N D T 405
Cdd:TIGR00239 318 EIVSPVVIGS T RAR LD R LN D s P E ST KVLAI LI HGD A A F AGQGVVQETLNMS KL RGY S VGGTI H I I INNQIGFTT - NP L D A 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 406 RST E YC T D I AKMIQAPI I HVN G DDPEAVAFA A R M AVEYR CL FKRD I FIDL IS YRRHGHNEADEP L ATQP M MY GL IKKHPT 485
Cdd:TIGR00239 397 RST P YC S D L AKMIQAPI F HVN A DDPEAVAFA T R L AVEYR NT FKRD V FIDL VG YRRHGHNEADEP S ATQP L MY QK IKKHPT 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 486 PRKVYAD R L IA EGV I T GD D EI EM M NLYRDAL DNG D R VVP E WREM D TAS MD W LQY LN Y EW TSP Y ES K FPEA R FL E I AKR VC 565
Cdd:TIGR00239 477 PRKVYAD K L VS EGV A T EE D VT EM V NLYRDAL EAA D C VVP S WREM N TAS FT W SPE LN H EW DEE Y PN K VEMK R LQ E L AKR IS 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 566 E Y PE ALRP H P RV E KIY N DR - RE M YQ G N KL L DWG M AE TM A Y ATL L DDG TH VRLSGED AG RGTFF H RHAV V H N Q ND G TG Y V P 644
Cdd:TIGR00239 557 E V PE GVEM H S RV A KIY F DR t KA M AA G E KL F DWG G AE NL A F ATL V DDG IP VRLSGED SE RGTFF Q RHAV L H D Q SN G ST Y T P 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 645 L T HLH AN QG R F E VW D SVLSEE A VL A FEYGYATT D P K TL T IWEAQFGDFANGAQ I VIDQFISSGEQKWG R M C GLVMLLPHG 724
Cdd:TIGR00239 637 L Q HLH NG QG A F R VW N SVLSEE S VL G FEYGYATT S P R TL V IWEAQFGDFANGAQ V VIDQFISSGEQKWG Q M S GLVMLLPHG 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 725 YEGQGPEHSS A RLER Y LQL C AEQNMQVC I P S TPAQV Y H M LRRQA I R K MRRPL IAI SPKSLLRHPLAVS T L D EL IN G E F KT 804
Cdd:TIGR00239 717 YEGQGPEHSS G RLER F LQL A AEQNMQVC V P T TPAQV F H I LRRQA L R G MRRPL VVM SPKSLLRHPLAVS S L E EL AE G T F QP 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 805 VIGE LDN ---- LDP AQ VKR V VLCSGKVYYDL L E E RR QRVKT DVAI I RIEQLYP Y PH ED VK KA L MP Y AHVTDY VWCQEEPL 880
Cdd:TIGR00239 797 VIGE IEE sgls LDP EG VKR L VLCSGKVYYDL H E Q RR KNGQK DVAI V RIEQLYP F PH KA VK EV L QQ Y PNLKEI VWCQEEPL 876
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 2490852290 881 N Q G V WY C S KHNFEAS IPE NATLK YAGRPASASPAVGYMSLH T KQQ TQ L VDE AL 933
Cdd:TIGR00239 877 N M G A WY Y S QPHLREV IPE GVSVR YAGRPASASPAVGYMSLH Q KQQ QD L LND AL 929
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
67-933
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1124.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 67 R L A RENRSEAVTVI D peasa K LVK V LQF I N AYR F RGHL E A KL DPL N Y y R WKTS qv P E LD YRY HG FSDK DL EET F TI G RYV 146
Cdd:PRK12270 370 R W A TDIPADHEDEV D ----- K NAR V MEL I H AYR V RGHL M A DT DPL E Y - R QRSH -- P D LD VLT HG LTLW DL DRE F PV G GFG 441
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 147 y N K DT MKL GELAEA L KET YC GSI G L E F MHIQD M EQ KN WLQ AKI E SVLN KP lf T K E QKVNL L TE L T AA DGL E RY L GA K FP G 226
Cdd:PRK12270 442 - G K ER MKL RDILGV L RDS YC RTV G I E Y MHIQD P EQ RR WLQ ERV E RPHE KP -- T R E EQKRI L SK L N AA EAF E TF L QT K YV G 518
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 227 A KRFSLEG SDAF IP MMKEIIRH A GRQ G MEN VV M GMAHRGRLN M L V N VL GK KPAEL F D EF A G KH ad D N R T ---- GDVKYH Q 302
Cdd:PRK12270 519 Q KRFSLEG GESL IP LLDAVLDQ A AEH G LDE VV I GMAHRGRLN V L A N IV GK PYSQI F R EF E G NL -- D P R S aqgs GDVKYH L 596
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 303 G FSSD F - DVD G KHVHLA LA F NPSHLE I V S PV VI G S VRA R Q T R IHD - T E HKK VL A I TV HGD S A V AGQGVV Q ETLN M S NA RG 380
Cdd:PRK12270 597 G AEGT F t QMF G DEIKVS LA A NPSHLE A V D PV LE G I VRA K Q D R LDK g E E GFT VL P I LL HGD A A F AGQGVV A ETLN L S QL RG 676
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 381 Y KV GGTI R IV I NNQ I GFTT S n P NDT RS T EY C TD I AKMIQAPI I HVNGDDPEAV AFA AR M A V EYR CL F KR D IF IDL IS YRR 460
Cdd:PRK12270 677 Y RT GGTI H IV V NNQ V GFTT A - P ESS RS S EY A TD V AKMIQAPI F HVNGDDPEAV VRV AR L A F EYR QR F HK D VV IDL VC YRR 755
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 461 H GHNE A D E P LA TQP M MY G LI KKHPTP RK V Y ADR LI AE G V IT GDDEIEMMNL Y RDA L D ngd RV VP E W RE MDTASMDWL -- Q 538
Cdd:PRK12270 756 R GHNE G D D P SM TQP L MY D LI DAKRSV RK L Y TEA LI GR G D IT VEEAEQALRD Y QGQ L E --- RV FN E V RE AEKKPPEPP es V 832
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 539 YLNYEWTSPYESKFPEARFLE I AKRVCEY PE ALRP HP RVEKIYND RREM - YQ G N kl L DW GMA E TM A YAT LL DD GT H VRLS 617
Cdd:PRK12270 833 ESDQGPPAGVDTAVSAEVLER I GDAHVNL PE GFTV HP KLKPLLEK RREM a RE G G -- I DW AFG E LL A FGS LL LE GT P VRLS 910
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 618 G E D AG RGTF FH RHAV VHNQND G TG Y V PL TH L HAN QG R F E V W DS V LSE E A VLA FEYGY ATTD P KT L TI WEAQFGDFANGAQ 697
Cdd:PRK12270 911 G Q D SR RGTF SQ RHAV LIDRET G EE Y T PL QN L SDD QG K F L V Y DS L LSE Y A AMG FEYGY SVER P DA L VL WEAQFGDFANGAQ 990
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 698 IV ID Q FISSGE Q KWG RMC G L V M LLPHGYEGQGP E HSSAR L ER Y LQLCAE Q NM Q V CI PSTPA QVY H M LRRQA IRKM RRPL I 777
Cdd:PRK12270 991 TI ID E FISSGE A KWG QRS G V V L LLPHGYEGQGP D HSSAR I ER F LQLCAE G NM T V AQ PSTPA NYF H L LRRQA LSGP RRPL V 1070
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 778 AIS PKS L LR HPL AVS TLDELIN G E F KT VI GELDNL D P A Q V K RV V LCSGK V YYDL LEE R RQRVKT D V AI I R I EQLYP Y P HE 857
Cdd:PRK12270 1071 VFT PKS M LR LKA AVS DVEDFTE G K F RP VI DDPTVD D G A K V R RV L LCSGK L YYDL AAR R EKDGRD D T AI V R V EQLYP L P RA 1150
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2490852290 858 DVKK AL MP Y AHV T DY VW C QEEP L NQG V W YCSKH N FEASI P ENAT L KYAG RPASASPA V G YMSL H TKQ Q TQ L V DEA L 933
Cdd:PRK12270 1151 ELRE AL AR Y PNA T EV VW V QEEP A NQG A W PFMAL N LPELL P DGRR L RRVS RPASASPA T G SAKV H AVE Q QE L L DEA F 1226
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
216-477
8.88e-159
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 466.24
E-value: 8.88e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 216 L E RY L GA KFPG A KRF S LEG SDAF IP MMK E I I RH A GRQ G M E N VV M GMAHRGRLN M L V NVLGK KPAEL F D EF A GK HA --- DD 292
Cdd:cd02016 1 F E QF L AT KFPG Q KRF G LEG AESL IP ALD E L I DR A AEL G V E E VV I GMAHRGRLN V L A NVLGK PLEQI F S EF E GK SE fpe DD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 293 NRT GDVKYH Q G F SSD FDVD - GK H VHL A LA F NPSHLE I V S PVV I G SV RA R Q TRIH D T E HK KVL A I TV HGD S A V AGQGVV Q E 371
Cdd:cd02016 81 EGS GDVKYH L G Y SSD RKTP s GK K VHL S LA P NPSHLE A V N PVV M G KT RA K Q DYRG D G E RD KVL P I LI HGD A A F AGQGVV Y E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 372 TLN M SN AR GY KV GGTI R IV I NNQIGFTT s N P N D T RS TE YCTD I AKMI Q API I HVNGDDPEAV AF A A R M A V EYR CL FK R D I 451
Cdd:cd02016 161 TLN L SN LP GY TT GGTI H IV V NNQIGFTT - D P R D S RS SP YCTD V AKMI G API F HVNGDDPEAV VR A T R L A L EYR QK FK K D V 239
250 260
....*....|....*....|....*.
gi 2490852290 452 F IDL IS YRRHGHNE A DEP LA TQP M MY 477
Cdd:cd02016 240 V IDL VC YRRHGHNE L DEP SF TQP L MY 265
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
791-933
1.32e-70
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 230.02
E-value: 1.32e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 791 V S T L D E LIN G - E F KT VI GELDN L - DP AQ VKRVVLCSGKVYYDLL E ER RQ R VK - T DVAI I RIEQLYP Y P HEDV K KA L MP Y A 867
Cdd:pfam16870 1 R S S L E E FTP G t H F QR VI PDPEP L v DP EK VKRVVLCSGKVYYDLL K ER EE R GG i K DVAI V RIEQLYP F P FDLL K EE L DK Y P 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2490852290 868 HVTDY VWCQEEP L NQG V W YCSKHNF E ASIP E - NAT L K YAGRP A SASPA V G YM S L H TKQ Q TQ L V D E A L 933
Cdd:pfam16870 81 NAAEI VWCQEEP K NQG A W SFVQPRL E TVLN E t GHR L R YAGRP P SASPA T G SK S V H LAE Q EA L L D D A F 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
594-786
1.43e-58
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 198.16
E-value: 1.43e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 594 LDWGM A ETM A Y A T L LDDGTH V RLS G E D AGR GTF FHRHAVV H nqndgtgyvplthlha N QG RFE V W D SVLS E E A VLA F EY G 673
Cdd:pfam02779 3 IATRK A SGE A L A E L AKRDPR V VGG G A D LAG GTF TVTKGLL H ---------------- P QG AGR V I D TGIA E Q A MVG F AN G 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 674 Y A TTD P k T L TIW EA Q F G DF A N gaqi VI D QF I SS G EQKWGRMCG - L V MLL P H G YEGQ GP E H S S ARLERY L QLCA eq NMQ V C 752
Cdd:pfam02779 67 M A LHG P - L L PPV EA T F S DF L N ---- RA D DA I RH G AALGKLPVP f V V TRD P I G VGED GP T H Q S VEDLAF L RAIP -- GLK V V 139
170 180 190
....*....|....*....|....*....|....
gi 2490852290 753 I PS TP A QVYHM LR RQAI R KM R R P LIAIS P KS LLR 786
Cdd:pfam02779 140 R PS DA A ETKGL LR AAIR R DG R K P VVLRL P RQ LLR 173
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
228-501
2.38e-42
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 156.72
E-value: 2.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 228 KRFSLEGSD A FIPMMKEI I RH A GRQ G m ENVVM G ma H R GRL N M L VNV L GKK pa E L F D E FA G KH A DDN rt G DVKYHQGFS sd 307
Cdd:pfam00676 21 GIRGFYHLY A GQEAAQVG I AA A LEP G - DYIIP G -- Y R DHG N L L ARG L SLE -- E I F A E LY G RV A KGK -- G GSMHGYYGA -- 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 308 fdvdg K HVHLALAFNPSHLEI vs P VVI G SVR A RQT R ihdte H KK VL AIT VH GD S A v A G QG VVQ E T LN MSNARGYK V ggt I 387
Cdd:pfam00676 92 ----- K GNRFYGGNGILGAQV -- P LGA G IAL A AKY R ----- G KK EV AIT LY GD G A - A N QG DFF E G LN FAALWKLP V --- I 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 388 RIVI NNQ I G FT T SNPNDTR ST E Y c T D I A KMIQA P II HV N G D DP E AV AF A ARM A V E YRCLF K RDIF I D L IS YR RH GH NEA D 467
Cdd:pfam00676 156 FVCE NNQ Y G IS T PAERASA ST T Y - A D R A RGYGI P GL HV D G M DP L AV YQ A SKF A A E RARTG K GPFL I E L VT YR YG GH SMS D 234
250 260 270
....*....|....*....|....*....|....*
gi 2490852290 468 E P LATQ - PMM Y GLIK K HPT P RKVYADR L IAE GV IT 501
Cdd:pfam00676 235 D P STYR t RDE Y EEVR K KKD P IQRFKEH L VSK GV WS 269
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
656-786
2.25e-29
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 113.74
E-value: 2.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 656 EVW D SVLS E E A VLA F EY G Y A TTD pkt L TIWEAQ F GD F ANG A QIV I DQFIS SG E qkwgr MCGLVMLLPH G YE G Q - GP E H S S 734
Cdd:smart00861 16 LAI D TGIA E Q A MVG F AA G L A LHG --- L RPVVEI F FT F FDR A KDQ I RSAGA SG N ----- VPVVFRHDGG G GV G E d GP T H H S 87
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2490852290 735 ARL E - RYLQLC aeq NMQ V CI PS T PA QVYHM LR R q AIR KMRRPL I AISP KSL L R 786
Cdd:smart00861 88 IED E a LLRAIP --- GLK V VA PS D PA EAKGL LR A - AIR DDGPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
12-50
4.79e-16
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 72.56
E-value: 4.79e-16
10 20 30
....*....|....*....|....*....|....*....
gi 2490852290 12 TTA L G GAN QS Y V EE I YEQYL E DP D SVD A SW Q A V F AQ L PK 50
Cdd:pfam16078 1 DSF L S GAN AA Y I EE L YEQYL K DP S SVD P SW R A Y F DN L DD 39
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
350-508
2.96e-10
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 62.51
E-value: 2.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 350 KKVL A ITVH GD S A v AGQ G VVQ E T LN M sn A RGY K VG g T I RIVI NN QIGFT T S npnd T RSTEYC T D IA KMIQ A --- P I I H V N 426
Cdd:cd02000 125 EDRV A VCFF GD G A - TNE G DFH E A LN F -- A ALW K LP - V I FVCE NN GYAIS T P ---- T SRQTAG T S IA DRAA A ygi P G I R V D 196
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 427 G D D PE AV AF AA RM AVE y R CLF - KRDIF I DLIS YR RH GH NEA D E P LA -- T QPMMYGLI K KH P TP R kv YADR LI AE G VI T GD 503
Cdd:cd02000 197 G N D VL AV YE AA KE AVE - R ARA g GGPTL I EAVT YR LG GH STS D D P SR yr T KEEVEEWK K RD P IL R -- LRKY LI EA G IL T EE 273
....*
gi 2490852290 504 DEIEM 508
Cdd:cd02000 274 ELAAI 278
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
17-47
3.75e-08
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 57.59
E-value: 3.75e-08
10 20 30
....*....|....*....|....*....|.
gi 2490852290 17 G A N QSY VEE I Y E QYL E DP D SVD A SW QAV FA Q 47
Cdd:PRK12270 5 G Q N EWL VEE M Y Q QYL A DP N SVD P SW REF FA D 35
PLN02269
PLN02269 Pyruvate dehydrogenase E1 component subunit alpha
354-467
8.39e-06
Pyruvate dehydrogenase E1 component subunit alpha
Pssm-ID: 215152 [Multi-domain]
Cd Length: 362
Bit Score: 48.94
E-value: 8.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490852290 354 A ITVH GD S A v A G QG VVQ E T LN MSNARGYK V ggt I RIVI NN QI G FT T SNPNDTR S TE Y ctdi A K MIQ - A P IIH V N G D D PE A 432
Cdd:PLN02269 163 A FALY GD G A - A N QG QLF E A LN IAALWDLP V --- I FVCE NN HY G MG T AEWRAAK S PA Y ---- Y K RGD y V P GLK V D G M D VL A 234
90 100 110
....*....|....*....|....*....|....*
gi 2490852290 433 V AF A ARM A V E Y r C L FKRD I FIDLIS YR R HGH NEA D 467
Cdd:PLN02269 235 V KQ A CKF A K E H - A L SNGP I VLEMDT YR Y HGH SMS D 268
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
