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Conserved domains on  [gi|2490864661|ref|WP_279425637|]
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DNA topoisomerase IV subunit A [Glaesserella parasuis]

Protein Classification

DNA topoisomerase IV subunit A( domain architecture ID 11481105)

DNA topoisomerase IV subunit A is part of topoisomerase IV that is essential for chromosome segregation; it relaxes supercoiled DNA and performs the decatenation events required during the replication of a circular DNA molecule

EC:  5.6.2.2
Gene Ontology:  GO:0009330|GO:0003918|GO:0005524|GO:0003677|GO:0006265
PubMed:  11395412
SCOP:  4007654

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-737 0e+00

DNA topoisomerase 4 subunit A;


:

Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 1284.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   1 MTTEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFH 80
Cdd:PRK05561    1 PPDMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  81 PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPK 160
Cdd:PRK05561   81 PHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPA-AAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 161 YLPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKIYEQG 240
Cdd:PRK05561  160 VLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGEIITGRDGIRKAYETG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 241 RGSIKMRAVWKREE-----NNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNRIDYDG 315
Cdd:PRK05561  240 RGSIRVRARWEIEDlaggrWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENPVRIVIEPKSNRVDPEA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 316 LMDHLFATTDLEKSYRINMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVI 395
Cdd:PRK05561  320 LMNHLFATTDLESSYRVNMNAIGLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVI 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 396 EIIRNEDNPKAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAK 475
Cdd:PRK05561  400 RIIRESDEPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAK 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 476 AFASPRRSPLVERAEAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQNLSYKAGDSYLAHAYGKSNQPVVFIDSTG 555
Cdd:PRK05561  480 KFGDPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSIDASGLSFKEGDSLLFAFEARTTDKLLLFTSTG 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 556 RSYALDPLSLPSARSQGEPITGKISLPDGATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLTENAKV 635
Cdd:PRK05561  560 RVYSLPVHELPSARGDGEPLTGLVDLAPGEEIVHVLAFDPDQKLLLASSAGYGFVVTLEDLVARTRAGKAVINLKDGDEV 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 636 LPPQLLKEGEEnlLVAMSNTGRVLVFPVSELPELSKGKGNKIINIsaqaaKERAELLSRLLIINPTSSLVFV-SGKRKIT 714
Cdd:PRK05561  640 LPPVPVEDDDH--LAAITSNGRLLVFPLSELPELGKGKGVKLINL-----PKDDDGLVDLRVLNPEDGLVLLtAGKRKLK 712

                         730       740
                  ....*....|....*....|....
gi 2490864661 715 LKPTDIEHYRGERARKGSQL-RGL 737
Cdd:PRK05561  713 LKPSELEKYRGKRARRGRLLpRGL 736
 
Name Accession Description Interval E-value
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-737 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 1284.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   1 MTTEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFH 80
Cdd:PRK05561    1 PPDMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  81 PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPK 160
Cdd:PRK05561   81 PHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPA-AAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 161 YLPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKIYEQG 240
Cdd:PRK05561  160 VLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGEIITGRDGIRKAYETG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 241 RGSIKMRAVWKREE-----NNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNRIDYDG 315
Cdd:PRK05561  240 RGSIRVRARWEIEDlaggrWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENPVRIVIEPKSNRVDPEA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 316 LMDHLFATTDLEKSYRINMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVI 395
Cdd:PRK05561  320 LMNHLFATTDLESSYRVNMNAIGLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVI 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 396 EIIRNEDNPKAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAK 475
Cdd:PRK05561  400 RIIRESDEPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAK 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 476 AFASPRRSPLVERAEAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQNLSYKAGDSYLAHAYGKSNQPVVFIDSTG 555
Cdd:PRK05561  480 KFGDPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSIDASGLSFKEGDSLLFAFEARTTDKLLLFTSTG 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 556 RSYALDPLSLPSARSQGEPITGKISLPDGATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLTENAKV 635
Cdd:PRK05561  560 RVYSLPVHELPSARGDGEPLTGLVDLAPGEEIVHVLAFDPDQKLLLASSAGYGFVVTLEDLVARTRAGKAVINLKDGDEV 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 636 LPPQLLKEGEEnlLVAMSNTGRVLVFPVSELPELSKGKGNKIINIsaqaaKERAELLSRLLIINPTSSLVFV-SGKRKIT 714
Cdd:PRK05561  640 LPPVPVEDDDH--LAAITSNGRLLVFPLSELPELGKGKGVKLINL-----PKDDDGLVDLRVLNPEDGLVLLtAGKRKLK 712

                         730       740
                  ....*....|....*....|....
gi 2490864661 715 LKPTDIEHYRGERARKGSQL-RGL 737
Cdd:PRK05561  713 LKPSELEKYRGKRARRGRLLpRGL 736
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 10-744 0e+00

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 1213.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  10 VEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYE 89
Cdd:TIGR01062   1 IENIDLGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  90 AMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHI 169
Cdd:TIGR01062  81 AMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 170 LLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKIYEQGRGSIKMRAV 249
Cdd:TIGR01062 161 LLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDKAEEIRKIYETGRGSFRMRAR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 250 WKREENNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNRIDYDGLMDHLFATTDLEKS 329
Cdd:TIGR01062 241 WKKEDGQIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENPIRVVIVPRSNRVDPDIVMEHLFATTDLEKS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 330 YRINMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNPKAELI 409
Cdd:TIGR01062 321 YRLNMNMIGLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVIEIIREEDEPKTILM 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 410 ARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAKAFASPRRSPLVERA 489
Cdd:TIGR01062 401 ERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKILKSERELNQLVKKEIQADATKYGLARRSSLEERE 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 490 EAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQNLSYKAGDSYLAHAYGKSNQPVVFIDSTGRSYALDPLSLPSAR 569
Cdd:TIGR01062 481 EAKQVSEIDMIPKEPVTIILSKMGWVRSAKGHDIDLSTLKYKAGDSEKAIIEGKSNQKVVFIDSTGRSYALDPDNLPSAR 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 570 SQGEPITGKISLPDGATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLTENAKVLPPQLLkEGEENLL 649
Cdd:TIGR01062 561 GQGEPLTGKLLLPIGATITNILMYSPNQLLLMASDAGYGFLCNFNDLIARNKAGKALINLPENASVIAPLPV-NGDSDMI 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 650 VAMSNTGRVLVFPVSELPELSKGKGNKIINISAQAAKERAELLSRLLIINPTSSLVFVSGKRKITLKPTDIEHYRGERAR 729
Cdd:TIGR01062 640 AAITEAGRMLVFPIDDLPELSKGKGNKLIRIPSANAKRGEDGLLDLKIFNKQDGLSWNDGKRKIQLEPEELQKFLGERGR 719

                         730
                  ....*....|....*.
gi 2490864661 730 KGSQL-RGLSGNVEVE 744
Cdd:TIGR01062 720 FGTTLpRGLPKNNRFS 735
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-731 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 837.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   1 MTTEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFH 80
Cdd:COG0188     1 MSDPPPAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  81 PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPD-DPKsfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEP 159
Cdd:COG0188    81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDgDPA--AAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 160 KYLPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItPRSEIAKIYEQ 239
Cdd:COG0188   159 TVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIV-GREGIREAYET 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 240 GRGSIKMRAVWKREE-----NNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDhENPIRIVLEPRSnRIDYD 314
Cdd:COG0188   238 GRGSIRVRAKAEIEElkrgrEQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESD-RDGMRIVIELKR-DANPE 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 315 GLMDHLFATTDLEKSYRINMNMIgLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEV 394
Cdd:COG0188   316 VVLNQLYKHTQLQTSFGINMLAL-VDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEV 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 395 IEIIRNEDNP---KAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIE 471
Cdd:COG0188   395 IAIIRASKDPdeaKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 472 ADAKAFASPRRSPLVEraEAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQN--------LSYKAGDsYLAHAY-G 542
Cdd:COG0188   475 EIKKKYGDERRTEIEE--AEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQRrggkgvsgMGTKEED-FVEHLFvA 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 543 KSNQPVVFIDSTGRSYALDPLSLP--SARSQGEPITGKISLPDGATVQYVLMA---EESRKVLMASDSGYGFICQFEDLV 617
Cdd:COG0188   552 STHDTLLFFTNKGRVYRLKVYELPegSRTAKGKPIVNLLPLEPGEKITAVLPVkefDEDKYLLFATKKGTVKKTPLSDFS 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 618 SRNKAGKAVISLTENAKVLPPQLLKeGEENLLVAMSNtGRVLVFPVSELPELS-KGKGNKIINIsaqaaKERAELLSrLL 696
Cdd:COG0188   632 NIRKNGIIAINLKEGDELVGVALTD-GDDDVLLATSN-GKAIRFPESDVRPMGrTARGVRGIRL-----KEGDEVVG-MA 703

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|
gi 2490864661 697 IINPTSSLVFVS----GKRkitlkpTDIEHYR-GERARKG 731
Cdd:COG0188   704 VVDEEDDLLTVTengyGKR------TPLSEYRlQGRGGKG 737
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 32-472 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 591.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  32 MDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNW 111
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 112 GAPDDpKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIAVGMATDIPPHNIN 191
Cdd:cd00187    81 GSRDG-DDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 192 ELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItPRSEIAKIYEQGRGSIKMRAVWKREE----NNIVINALPHQAS 267
Cdd:cd00187   160 EVIDALRALIDNPEASIDELMEIIKGPDFPTGGIIE-GRAGIREAYETGRGRYIIRGKYEIEDdegrNTIEITELPYQVN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 268 PSKVIEQIATQMRNKKLPMVDDIRDESDHeNPIRIVLEPRSNRIDyDGLMDHLFATTDLEKSYRINMNMIGLDGKPAVKN 347
Cdd:cd00187   239 KAKLKEKIAELVKDKKIEGISDVRDESDR-EGIRFVIELKRGAMA-EVVLNGLYKVTKLQTTFGINMVAFDPNGRPKKLN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 348 LLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNPKAELIARFQ---LSDEQAEAILN 424
Cdd:cd00187   317 LKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSSDEAKKALIEELEklgFSEIQADAILD 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2490864661 425 LRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEA 472
Cdd:cd00187   397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDE 444
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 13-463 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 568.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   13 MPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMV 92
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   93 LMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLN 172
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRLDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  173 GTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItprseiakiyeqGRGSIKMRAVWKR 252
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV------------GPGKYVVRGKIEI 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  253 EENN-IVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNrIDYDGLMDHLFATTDLEKSYR 331
Cdd:smart00434 229 EDDNtIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDESHDRTGVRIVIELKRG-AMAEVVLNGLYKLTKLQTTFS 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  332 INMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKI-ISRLHILEGLMIAFLNIDEVIEIIRNEDNP----KA 406
Cdd:smart00434 308 INMLALFDNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLeAERLHILEGLFIALSIIDEIIVLIRSSKDLakeaKE 387

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2490864661  407 ELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLN 463
Cdd:smart00434 388 KLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
34-471 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 534.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  34 RALPFIGDGLKPVQRRIIYAMSELgLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGA 113
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 114 PDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIAVGMATDIPPHNINEL 193
Cdd:pfam00521  80 RIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 194 AAASVKLLDNPTASLsdILDVVQGPDYPTEAEIItPRSEIAKIYEQGRGSIKMRAVWKREE-NNIVINALPHQASPSKVI 272
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGII-GKGGIKEAYKTGRGKITVRAKVEIEDrKTIVITELPYGVWTSDLI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 273 EQIATQMRNKKLPMVDDIRDESDheNPIRIVLEPRSNrIDYDGLMDHLFATTDLEKSYRINMNMIGlDGKPAVKNLLTIL 352
Cdd:pfam00521 237 EKIEELVKNGKIKGISDIRDESD--RGVRIVIELKRG-ADPEVVLNDLYKKTKLQTSFSTNNLVLF-DGGPKYLGLKEIL 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 353 TEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDN---PKAELIARfqLSDEQAEAILNLRLRH 429
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDrkkAKKNLIEE--LSEIQADYLLDMRLRR 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2490864661 430 LAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIE 471
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
 
Name Accession Description Interval E-value
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-737 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 1284.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   1 MTTEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFH 80
Cdd:PRK05561    1 PPDMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  81 PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPK 160
Cdd:PRK05561   81 PHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPA-AAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 161 YLPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKIYEQG 240
Cdd:PRK05561  160 VLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGEIITGRDGIRKAYETG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 241 RGSIKMRAVWKREE-----NNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNRIDYDG 315
Cdd:PRK05561  240 RGSIRVRARWEIEDlaggrWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENPVRIVIEPKSNRVDPEA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 316 LMDHLFATTDLEKSYRINMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVI 395
Cdd:PRK05561  320 LMNHLFATTDLESSYRVNMNAIGLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVI 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 396 EIIRNEDNPKAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAK 475
Cdd:PRK05561  400 RIIRESDEPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAK 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 476 AFASPRRSPLVERAEAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQNLSYKAGDSYLAHAYGKSNQPVVFIDSTG 555
Cdd:PRK05561  480 KFGDPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSIDASGLSFKEGDSLLFAFEARTTDKLLLFTSTG 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 556 RSYALDPLSLPSARSQGEPITGKISLPDGATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLTENAKV 635
Cdd:PRK05561  560 RVYSLPVHELPSARGDGEPLTGLVDLAPGEEIVHVLAFDPDQKLLLASSAGYGFVVTLEDLVARTRAGKAVINLKDGDEV 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 636 LPPQLLKEGEEnlLVAMSNTGRVLVFPVSELPELSKGKGNKIINIsaqaaKERAELLSRLLIINPTSSLVFV-SGKRKIT 714
Cdd:PRK05561  640 LPPVPVEDDDH--LAAITSNGRLLVFPLSELPELGKGKGVKLINL-----PKDDDGLVDLRVLNPEDGLVLLtAGKRKLK 712

                         730       740
                  ....*....|....*....|....
gi 2490864661 715 LKPTDIEHYRGERARKGSQL-RGL 737
Cdd:PRK05561  713 LKPSELEKYRGKRARRGRLLpRGL 736
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 10-744 0e+00

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 1213.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  10 VEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYE 89
Cdd:TIGR01062   1 IENIDLGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  90 AMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHI 169
Cdd:TIGR01062  81 AMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 170 LLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKIYEQGRGSIKMRAV 249
Cdd:TIGR01062 161 LLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDKAEEIRKIYETGRGSFRMRAR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 250 WKREENNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNRIDYDGLMDHLFATTDLEKS 329
Cdd:TIGR01062 241 WKKEDGQIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENPIRVVIVPRSNRVDPDIVMEHLFATTDLEKS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 330 YRINMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNPKAELI 409
Cdd:TIGR01062 321 YRLNMNMIGLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVIEIIREEDEPKTILM 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 410 ARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAKAFASPRRSPLVERA 489
Cdd:TIGR01062 401 ERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKILKSERELNQLVKKEIQADATKYGLARRSSLEERE 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 490 EAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQNLSYKAGDSYLAHAYGKSNQPVVFIDSTGRSYALDPLSLPSAR 569
Cdd:TIGR01062 481 EAKQVSEIDMIPKEPVTIILSKMGWVRSAKGHDIDLSTLKYKAGDSEKAIIEGKSNQKVVFIDSTGRSYALDPDNLPSAR 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 570 SQGEPITGKISLPDGATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLTENAKVLPPQLLkEGEENLL 649
Cdd:TIGR01062 561 GQGEPLTGKLLLPIGATITNILMYSPNQLLLMASDAGYGFLCNFNDLIARNKAGKALINLPENASVIAPLPV-NGDSDMI 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 650 VAMSNTGRVLVFPVSELPELSKGKGNKIINISAQAAKERAELLSRLLIINPTSSLVFVSGKRKITLKPTDIEHYRGERAR 729
Cdd:TIGR01062 640 AAITEAGRMLVFPIDDLPELSKGKGNKLIRIPSANAKRGEDGLLDLKIFNKQDGLSWNDGKRKIQLEPEELQKFLGERGR 719

                         730
                  ....*....|....*.
gi 2490864661 730 KGSQL-RGLSGNVEVE 744
Cdd:TIGR01062 720 FGTTLpRGLPKNNRFS 735
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-731 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 837.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   1 MTTEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFH 80
Cdd:COG0188     1 MSDPPPAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  81 PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPD-DPKsfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEP 159
Cdd:COG0188    81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDgDPA--AAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 160 KYLPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItPRSEIAKIYEQ 239
Cdd:COG0188   159 TVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIV-GREGIREAYET 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 240 GRGSIKMRAVWKREE-----NNIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDhENPIRIVLEPRSnRIDYD 314
Cdd:COG0188   238 GRGSIRVRAKAEIEElkrgrEQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESD-RDGMRIVIELKR-DANPE 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 315 GLMDHLFATTDLEKSYRINMNMIgLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEV 394
Cdd:COG0188   316 VVLNQLYKHTQLQTSFGINMLAL-VDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEV 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 395 IEIIRNEDNP---KAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIE 471
Cdd:COG0188   395 IAIIRASKDPdeaKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 472 ADAKAFASPRRSPLVEraEAKAISESDLTPTEPVTVILSEKGWVRCAKGHDIDVQN--------LSYKAGDsYLAHAY-G 542
Cdd:COG0188   475 EIKKKYGDERRTEIEE--AEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQRrggkgvsgMGTKEED-FVEHLFvA 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 543 KSNQPVVFIDSTGRSYALDPLSLP--SARSQGEPITGKISLPDGATVQYVLMA---EESRKVLMASDSGYGFICQFEDLV 617
Cdd:COG0188   552 STHDTLLFFTNKGRVYRLKVYELPegSRTAKGKPIVNLLPLEPGEKITAVLPVkefDEDKYLLFATKKGTVKKTPLSDFS 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 618 SRNKAGKAVISLTENAKVLPPQLLKeGEENLLVAMSNtGRVLVFPVSELPELS-KGKGNKIINIsaqaaKERAELLSrLL 696
Cdd:COG0188   632 NIRKNGIIAINLKEGDELVGVALTD-GDDDVLLATSN-GKAIRFPESDVRPMGrTARGVRGIRL-----KEGDEVVG-MA 703

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|
gi 2490864661 697 IINPTSSLVFVS----GKRkitlkpTDIEHYR-GERARKG 731
Cdd:COG0188   704 VVDEEDDLLTVTengyGKR------TPLSEYRlQGRGGKG 737
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 20-724 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 620.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  20 EDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFS 99
Cdd:PRK05560   15 KRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 100 YRYPLIDGQGNWGAPD-DPKsfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIA 178
Cdd:PRK05560   95 MRYPLVDGQGNFGSIDgDPA--AAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 179 VGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITpRSEIAKIYEQGRGSIKMRAVWKREENN-- 256
Cdd:PRK05560  173 VGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILG-RSGIREAYRTGRGSIVMRAKAEIEEIKgr 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 257 --IVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENpIRIVLEPR----SNRIdydglMDHLFATTDLEKSY 330
Cdd:PRK05560  252 eaIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDG-MRIVIELKrdavPEVV-----LNNLYKHTQLQTSF 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 331 riNMNMIGL-DGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNP---KA 406
Cdd:PRK05560  326 --GINMLALvDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPaeaKE 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 407 ELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAKAFASPRRSPLV 486
Cdd:PRK05560  404 GLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPERLLEIIKEELLEIKEKFGDPRRTEII 483

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 487 ERAEakAISESDLTPTEPVTVILSEKGWV------------RCAKGhdidVQNLSYKAGDsYLAHAYGKSN-QPVVFIDS 553
Cdd:PRK05560  484 EGEG--DIDDEDLIPEEDVVVTLTHGGYIkrtpldeyraqrRGGKG----VSGAKTKEDD-FVEHLFVASThDTLLFFTN 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 554 TGRSYALD----PLSLPSAR----------SQGEPITGKISLPDGATVQYVLMAEES---RKVLMasdsgygficqfEDL 616
Cdd:PRK05560  557 RGRVYRLKvyeiPEASRTARgrpivnllplEPGEKITAILPVREFDDDKYLFFATKNgtvKKTSL------------SEF 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 617 VSRNKAGKAVISLTENAKVLPPQLLKEGEENLLVamSNTGRVLVFPVSELPELSKG-KGNKIINIsaqaaKERAELLSrL 695
Cdd:PRK05560  625 SNIRSNGIIAINLDEGDELIGVRLTDGDDDILLA--TKNGKAIRFPESDVRPMGRTaRGVRGIKL-----REGDEVVS-M 696

                         730       740       750
                  ....*....|....*....|....*....|....
gi 2490864661 696 LIINPTSSLVFV-----SGKRkitlkpTDIEHYR 724
Cdd:PRK05560  697 DVVREDSQEILTvtengYGKR------TPVSEYR 724
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 20-731 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 595.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  20 EDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFS 99
Cdd:TIGR01063  11 KRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 100 YRYPLIDGQGNWGAPD-DPKsfAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIA 178
Cdd:TIGR01063  91 LRYPLVDGQGNFGSIDgDPP--AAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 179 VGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITpRSEIAKIYEQGRGSIKMRAVWKREEN--- 255
Cdd:TIGR01063 169 VGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILG-RSGIRSAYETGRGSIVIRARAEIEEDskg 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 256 --NIVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENpIRIVLEPRSnriDYDG--LMDHLFATTDLEKSYR 331
Cdd:TIGR01063 248 reAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREG-IRIVIELKR---DAVAevVLNNLYKQTQLQVSFG 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 332 INMNMIgLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNP---KAEL 408
Cdd:TIGR01063 324 INMLAL-VKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVIALIRASQNTeeaKTRL 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 409 IARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAKAFASPRRSPLVER 488
Cdd:TIGR01063 403 VERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEERVLEIIREELEEIKEQFGDPRRTEIVYD 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 489 AEAKaISESDLTPTEPVTVILSEKGWV------------RCAKGhdidVQNLSYKAGDSyLAHAYGKSNQ-PVVFIDSTG 555
Cdd:TIGR01063 483 ESED-IDIEDLIARENVVVTLSHNGYVkrvpvsayrlqkRGGKG----VSGADMKDDDF-IEQLLVASTHdYLLFFTNRG 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 556 RSYALDPLSLPSA--RSQGEPITGKISLPDG---ATVQYVLMAEESRKVLMASDSGYGFICQFEDLVSRNKAGKAVISLT 630
Cdd:TIGR01063 557 KVYWLKVYQIPEAsrTAKGKPIVNLLPLQPDeriTAILSVKEFDDGLYLFFATKNGVVKKTSLTEFSNIRSNGIIAIKLD 636

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 631 ENAKVLPPQLLKEGEENLLVamSNTGRVLVFPVSELPELSKG-KGNKIINIsaqaAKEraELLSRLLIINPTSSLVFVS- 708
Cdd:TIGR01063 637 DGDELISVRLTSGEDEVMLG--SKNGKAVRFPEEDVRPMGRAaRGVRGIKL----KNE--DFVVSLLVVSEESYLLIVTe 708

                         730       740
                  ....*....|....*....|....*..
gi 2490864661 709 ---GKRkitlkpTDIEHYRGE-RARKG 731
Cdd:TIGR01063 709 ngyGKR------TSIEEYRETsRGGKG 729
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 32-472 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 591.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  32 MDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNW 111
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 112 GAPDDpKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIAVGMATDIPPHNIN 191
Cdd:cd00187    81 GSRDG-DDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 192 ELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItPRSEIAKIYEQGRGSIKMRAVWKREE----NNIVINALPHQAS 267
Cdd:cd00187   160 EVIDALRALIDNPEASIDELMEIIKGPDFPTGGIIE-GRAGIREAYETGRGRYIIRGKYEIEDdegrNTIEITELPYQVN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 268 PSKVIEQIATQMRNKKLPMVDDIRDESDHeNPIRIVLEPRSNRIDyDGLMDHLFATTDLEKSYRINMNMIGLDGKPAVKN 347
Cdd:cd00187   239 KAKLKEKIAELVKDKKIEGISDVRDESDR-EGIRFVIELKRGAMA-EVVLNGLYKVTKLQTTFGINMVAFDPNGRPKKLN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 348 LLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDNPKAELIARFQ---LSDEQAEAILN 424
Cdd:cd00187   317 LKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSSDEAKKALIEELEklgFSEIQADAILD 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2490864661 425 LRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEA 472
Cdd:cd00187   397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDE 444
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 13-463 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 568.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   13 MPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMV 92
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   93 LMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLN 172
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRLDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  173 GTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIItprseiakiyeqGRGSIKMRAVWKR 252
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV------------GPGKYVVRGKIEI 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  253 EENN-IVINALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVLEPRSNrIDYDGLMDHLFATTDLEKSYR 331
Cdd:smart00434 229 EDDNtIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDESHDRTGVRIVIELKRG-AMAEVVLNGLYKLTKLQTTFS 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  332 INMNMIGLDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKI-ISRLHILEGLMIAFLNIDEVIEIIRNEDNP----KA 406
Cdd:smart00434 308 INMLALFDNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLeAERLHILEGLFIALSIIDEIIVLIRSSKDLakeaKE 387

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2490864661  407 ELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLN 463
Cdd:smart00434 388 KLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
34-471 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 534.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  34 RALPFIGDGLKPVQRRIIYAMSELgLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGA 113
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 114 PDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIAVGMATDIPPHNINEL 193
Cdd:pfam00521  80 RIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 194 AAASVKLLDNPTASLsdILDVVQGPDYPTEAEIItPRSEIAKIYEQGRGSIKMRAVWKREE-NNIVINALPHQASPSKVI 272
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGII-GKGGIKEAYKTGRGKITVRAKVEIEDrKTIVITELPYGVWTSDLI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 273 EQIATQMRNKKLPMVDDIRDESDheNPIRIVLEPRSNrIDYDGLMDHLFATTDLEKSYRINMNMIGlDGKPAVKNLLTIL 352
Cdd:pfam00521 237 EKIEELVKNGKIKGISDIRDESD--RGVRIVIELKRG-ADPEVVLNDLYKKTKLQTSFSTNNLVLF-DGGPKYLGLKEIL 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 353 TEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIRNEDN---PKAELIARfqLSDEQAEAILNLRLRH 429
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDrkkAKKNLIEE--LSEIQADYLLDMRLRR 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2490864661 430 LAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIE 471
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 12-569 3.55e-123

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 391.39  E-value: 3.55e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  12 QMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAM 91
Cdd:PRK13979   15 KIPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  92 VLMAQPFSYRYPLIDGQGNWGAPDDpKSFAAMRYTESKLSKMAEILLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILL 171
Cdd:PRK13979   95 VILAQDFTTRMPLIDGHGNWGSIDG-DSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 172 NGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSDILDVVQGPDYPTEAEIITPRSEIAKiYEQGRGSIKMRAVWK 251
Cdd:PRK13979  174 NGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSA-YETGEGKVTLRAKTK 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 252 RE--ENN---IVINALPHQASPSKVIEQIATQMRNKK----LPMVDDIRDESDhENPIRIVLE-PRSNRIDY-DGLMDHL 320
Cdd:PRK13979  253 IEklENGrlgIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESD-RNGIRAVIEfKKSADEDVaEKVLKYL 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 321 FATTDLEKSyrINMNMIGL-DGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILEGLMIAFLNIDEVIEIIR 399
Cdd:PRK13979  332 YKKTDLQCN--ISFNMVALaDGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGFIKAIGIMDEIIKTIR 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 400 NEDNPK---AELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQGILGSERRLNNLIKKEIEADAKA 476
Cdd:PRK13979  410 SSKSKKdasENLIEKFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKLTKILSSEKELLKVIKKELKEVKEK 489

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 477 FASPRRSPLVERAEAKAISESDLTPTEPVTVILSEKGWV-----RCAKGHDIDVQNLSYKAGDS--YLAHAYGKSNQpVV 549
Cdd:PRK13979  490 YGDERRTSIIEDDEKAKIDVEELIVVEDVVITLSNEGFIkriplKSYNRSNSNVEDIEYREGDFnkFLIQSNTKDTL-LI 568

                         570       580
                  ....*....|....*....|
gi 2490864661 550 FIDStGRSYALDPLSLPSAR 569
Cdd:PRK13979  569 FTDK-GNMYQIKGINIPEFK 587
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 13-500 1.86e-57

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 206.87  E-value: 1.86e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  13 MPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGlnaAAKYKKSARTVGDVLgKFHPHGDSACYEAMV 92
Cdd:PRK09631    2 MDIKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLFEMH---DGKFHKVANVVGNTM-KYHPHGDASIYEALV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  93 LMAQpfsyRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLgeLGQGTVDYQPNFDGSLEEPKYLPARLPHILLN 172
Cdd:PRK09631   78 NLAN----KDLFIDKQGNFGNLFTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILIQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 173 GTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSdildvvqgPDYPTEAeiITPRSEiakiYEQGRGSIKMRA-VWK 251
Cdd:PRK09631  152 GAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGG--IVDVSE----YADGNGKVLVRAkIET 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 252 REENNIVINALPHQASPSKVIEQIATQMRNKKLPmVDDIRDESDHENPIRIVLePRSnrIDYDGLMDHLFATTDLEKSYR 331
Cdd:PRK09631  218 KDEKTIVIREIPFGTTTESLIASIEKAARKGKIK-ISSINDYTAENVEIEIKL-PRG--VYASEVIEALYAYTDCEVSIS 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 332 INMNMIGlDGKPAVKNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLH--ILEGLMIA---FLNIDE------VIEIIRN 400
Cdd:PRK09631  294 VNLLVIK-DRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKIFakTLEQIFIEeriYKRIETisseedVISIVLS 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 401 EDNPKAELIARfQLSDEQAEAILNLRLRHLAKLE----EHELKAEQQKLEEEREHLQGILG-SERRLNNLIKKEieadAK 475
Cdd:PRK09631  373 ELKPFKEELSR-DVTEEDIENLLKIPIRRISLFDidknQKEIRILNKELKSVEKNLKSIKGyAINFIDKLLAKY----SK 447

                         490       500
                  ....*....|....*....|....*..
gi 2490864661 476 AFasPRRS--PLVERAEAKAISESDLT 500
Cdd:PRK09631  448 EY--PRKTeiSLIKSVDVREIATKNLK 472
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
3-471 3.32e-53

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 198.30  E-value: 3.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   3 TEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGlnaAAKYKKSARTVGDVLgKFHPH 82
Cdd:PRK12758   11 EEESSEDEALTHVSGMYKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMD---DGRYNKVANVVGHTM-QYHPH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  83 GDSACYEAMVLMAQpfsyRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMA-EILLGElgqGTVDYQPNFDGSLEEPKY 161
Cdd:PRK12758   87 GDASIGDALVQLGQ----KDLLIDTQGNWGNILTGDGAAAPRYIEARLSKFAlEVVFNP---KTTEWQLSYDGRKKEPVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 162 LPARLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNPTASLSdildvvqgPDYPTEAEIitprsEIAKiYEQGR 241
Cdd:PRK12758  160 LPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGGII-----DVSN-YNDGE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 242 --GSIKMRA-VWKREENNIVINALPHQASPSKVIEQIATQMRNKKLPmVDDIRDESDHENPIRIVLEPrsnRIDYDGLMD 318
Cdd:PRK12758  226 rgGRVRVRAkIEKLDKKTLVITEIPYGTTTSSLIDSILKANDKGKIK-IKKVEDNTAADVEILVHLAP---GVSPDKTID 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 319 HLFATTDLEKSYRINMNMIgLDGKP---AVKNLLTILTEwlafrRTT--VTRRLNFRLDKIISRLHI--LEGLMI----- 386
Cdd:PRK12758  302 ALYAFTDCEVSISPNACVI-IDNKPhflGVSDILRRSTD-----HTVslLKQELEIRLSELEEQWHFasLEKIFIeeriy 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 387 ----AFLNIDEVIEIIRNEDNPKAELIARfQLSDEQAEAILNLRLRHLAKLEEHelKAEQ--QKLEEEREHLqgilgsER 460
Cdd:PRK12758  376 keieEAETWEAVIEAIDKGLEPFKKQFIR-EVTEDDIVRLTEIKIKRISKFDSD--KADEliARLEAEIAEV------KH 446

                         490
                  ....*....|.
gi 2490864661 461 RLNNLIKKEIE 471
Cdd:PRK12758  447 HLAHLTDYAIA 457
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 23-304 2.33e-38

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 149.27  E-value: 2.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  23 YLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGlnaAAKYKKSARTVGDVLGkFHPHGDSACYEAMVLMAQpfsyRY 102
Cdd:PRK09630   12 FMHYASYVILERAIPHILDGLKPVQRRLLWTLFRMD---DGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLAN----KG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 103 PLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEILLgeLGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTTGIAVGMA 182
Cdd:PRK09630   84 YLIDTQGNFGNPLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 183 TDIPPHNINELAAASVKLLDNPTASLSdildvvqgPDYPTEAeiITPRSEiakiYEQGRGSIKMRA-VWKREENNIVINa 261
Cdd:PRK09630  162 TKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGG--TMDASE----YQDGLGSITLRAsIDIINDKTLLIK- 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2490864661 262 lphQASPSKVIEQIATQMRN---KKLPMVDDIRDESDHENPIRIVL 304
Cdd:PRK09630  227 ---EICPSTTTETLIRSIENaakRGIIKIDSIQDFSTDLPHIEIKL 269
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 15-454 3.55e-34

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 135.95  E-value: 3.55e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  15 IKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHPHGDSACYEAMVLM 94
Cdd:PHA02592    8 LKSIVNNEALEYAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVADLGYHHGETSAQDAGALM 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  95 AQPFSYRYPLIDGQGNWGAPDDPKSfAAMRYTESKLSKMAEILLGElgqgtVDYQPNF-DGSLEEPK-YLPArLPHILLN 172
Cdd:PHA02592   88 ANTWNNNIPLLDGQGNFGSRLVQKA-AAARYIFARVHDNFRKIYKD-----EDLAPVHeDPEHIPPAfYLPI-IPMVLLN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 173 GTTGIAVGMATDIPPHNINELAAASVKLLdnptaslsdildvvQGPDyPTEAEIITP--RSEIAKIyeqGRGSIKMRAVW 250
Cdd:PHA02592  161 GVSGIATGYATNILPHSPKSVIKAVLAAL--------------NGKD-ITEPKVQFPefKGEVVEI---EPGSYEIRGTY 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 251 KRE-ENNIVINALPHQASPSKVIEqIATQMRNKKLPMVDDirDESDHENPIRIVLeprsnRIDYDGLMDHlfatTDLEKS 329
Cdd:PHA02592  223 ELNgKTKLHITEIPVKYDRETYVA-VLDPLEEKGKIVSYD--DCTEDGFRFKVTL-----KREENEEATH----EKIMKD 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661 330 YRI------NMNMIGLDGKPAV-KNLLTILTEWLAFRRTTVTRRLNFRLDKIISRLHILeGLMIAFLN--IDEVIEIIRN 400
Cdd:PHA02592  291 FGLiervsqNITVINENGKLKVyENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLA-LAKAEFIKrvIAGEIVLQGK 369

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2490864661 401 EDNPKAELIARFQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEEREHLQG 454
Cdd:PHA02592  370 TRSELTEELSDNKDFGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKK 423
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 15-470 1.01e-21

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 101.28  E-value: 1.01e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   15 IKRFTEDAYLNYSM---------------YVIMD--RALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVlG 77
Cdd:PTZ00108   644 ITNYKGGTYVDHSKkkltysdfvnkelilFSIADneRSIPSLVDGLKPGQRKILFACFKRNLKNEIKVAQLSGYVSEH-S 722

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   78 KFHpHGDSACYEAMVLMAQPF--SYRYPLI--DGQ-------GnwgapddpKSFAAMRYTESKLSKMAEILLGELGQGTV 146
Cdd:PTZ00108   723 AYH-HGEQSLQQTIVGMAQNFvgSNNINLLypCGQfgsrlqgG--------KDHAAARYIFTKLSKITRYIFPEEDDPIL 793

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  147 DYQpNFDGSLEEPK-YLPArLPHILLNGTTGIAVGMATDIPPHNINELAAASVKLLDNptaslsdilDVVQGpdypteae 225
Cdd:PTZ00108   794 DYL-EDDGQSVEPFyYVPI-IPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNG---------EEVRP-------- 854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  226 iITP--RSEIAKIYEQGRGSIKMRAVW-KREENNIVINALPHQASPSKVIEQIATQMrNKKLPMVDDIRDESDHeNPIRI 302
Cdd:PTZ00108   855 -LVPwyRGFKGTIERNPKGKFISKGIYeKVPDGTVEITELPIGKWTEDYKEFLESET-LKEKDVIVDYRDYSTA-NTVHF 931

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  303 VLEPRsnridyDGLMDHlFATTDLEK------SYRINmNMIGLDGKPAVK---NLLTILTEWLAFRRTTVTRRLNFRLDK 373
Cdd:PTZ00108   932 TVKLN------DGVLEQ-WEEEGIEKvfklksTISTT-NMVLFDENGKIKkysDALDILKEFYLVRLDLYKKRKEYLLGK 1003

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  374 IISRLHILEGlMIAFLNidEVIE---IIRNEdnPKAELIArfQLSDEQAEAILNLRLRHLAKLEEHELKAEQQKLEEERE 450
Cdd:PTZ00108  1004 LERELARLSN-KVRFIK--HVINgelVITNA--KKKDLVK--ELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDE 1076

                          490       500
                   ....*....|....*....|
gi 2490864661  451 HLQGILGSERRLNNLIKKEI 470
Cdd:PTZ00108  1077 DDEEELGAAVSYDYLLSMPI 1096
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 18-342 1.10e-13

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 75.13  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   18 FTEDAYLNYSMYvIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDvLGKFHpHGDSACYEAMVLMAQP 97
Cdd:PLN03128   658 FINKELILFSQA-DLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKVAQLSGYVAE-HSAYH-HGEASLASTIIGMAQD 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   98 F--SYRYPLIDGQGNWGAP-DDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQpNFDGSLEEPKYLPARLPHILLNGT 174
Cdd:PLN03128   735 FvgSNNINLLTPSGQFGTRlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEWYCPIIPMVLVNGS 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  175 TGIAVGMATDIPPHNINELAAASVKLLDNptaslsdildvvqgpdypTEAEIITP-----RSEIAKIYEQGRGSIKMRAV 249
Cdd:PLN03128   814 EGIGTGWSTFIPNYNPRDIIANIRRLLRG------------------EELEPMHPwyrgfKGTITEVSTSRSGSYTVTGI 875

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  250 W-KREENNIVINALP--HQASPSKVIEQIATQMRNKKLPMVDDIRDESDHEN-PIRIVLEPRS-NRIDYDGLMDHLFATT 324
Cdd:PLN03128   876 IeQIGDTTIRITELPvrKWTQDYKEFLEALLTGTKKKEPEIKDFKENHTDTTvHFTVTLSEEKmARALAEGLEKKFKLST 955

                          330
                   ....*....|....*...
gi 2490864661  325 DLEKSyriNMNMIGLDGK 342
Cdd:PLN03128   956 TISTS---NMHLFDKDGK 970
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 26-202 6.39e-12

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 69.51  E-value: 6.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661   26 YSMYVIMdRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYkksARTVGDV--LGKFHpHGDSACYEAMVLMAQPF--SYR 101
Cdd:PLN03237   691 FSMADLQ-RSIPSMVDGLKPGQRKILFCSFKRNFVKEAKV---AQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgSNN 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2490864661  102 YPLIDGQGNWGA-PDDPKSFAAMRYTESKLSKMAEILLGELGQGTVDYQpNFDGSLEEPKYLPARLPHILLNGTTGIAVG 180
Cdd:PLN03237   766 INLLLPNGQFGTrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTWYMPIIPTVLVNGAEGIGTG 844

                          170       180
                   ....*....|....*....|..
gi 2490864661  181 MATDIPPHNINELAAASVKLLD 202
Cdd:PLN03237   845 WSTFIPNYNPRDIVANIRRLLN 866
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
 649-699 1.20e-03

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 37.47  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2490864661 649 LVAMSNTGRVLVFPVSELPELSKG-KGNKIINIsaqaaKERAELLSrLLIIN 699
Cdd:pfam03989   3 LLLITSKGYVKRTPLSEIREQGRGaKGVKGINL-----KEGDKVVS-VLVVN 48
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
 598-635 7.21e-03

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 35.16  E-value: 7.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2490864661 598 KVLMASDSGYGFICQFEDLV--SRNKAGKAVISLTENAKV 635
Cdd:pfam03989   2 ELLLITSKGYVKRTPLSEIReqGRGAKGVKGINLKEGDKV 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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