sensor histidine kinase [Micromonospora sp. DH14]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||
| PRK11086 super family | cl35987 | sensory histidine kinase DcuS; Provisional |
40-527 | 2.65e-114 | ||||||||
sensory histidine kinase DcuS; Provisional The actual alignment was detected with superfamily member PRK11086: Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 348.83 E-value: 2.65e-114
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| Name | Accession | Description | Interval | E-value | ||||||||
| PRK11086 | PRK11086 | sensory histidine kinase DcuS; Provisional |
40-527 | 2.65e-114 | ||||||||
sensory histidine kinase DcuS; Provisional Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 348.83 E-value: 2.65e-114
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| CitA | COG3290 | Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
205-526 | 2.01e-110 | ||||||||
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms]; Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 333.74 E-value: 2.01e-110
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| HATPase_DpiB-CitA-like | cd16915 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-522 | 1.22e-31 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain. Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 117.77 E-value: 1.22e-31
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| HATPase_c | smart00387 | Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
421-522 | 7.85e-25 | ||||||||
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 98.88 E-value: 7.85e-25
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| sCache_3_2 | pfam17203 | Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
35-171 | 6.29e-23 | ||||||||
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 94.40 E-value: 6.29e-23
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| cztS_silS_copS | TIGR01386 | heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
396-522 | 5.85e-11 | ||||||||
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 64.72 E-value: 5.85e-11
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| Name | Accession | Description | Interval | E-value | ||||||||
| PRK11086 | PRK11086 | sensory histidine kinase DcuS; Provisional |
40-527 | 2.65e-114 | ||||||||
sensory histidine kinase DcuS; Provisional Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 348.83 E-value: 2.65e-114
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| CitA | COG3290 | Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
205-526 | 2.01e-110 | ||||||||
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms]; Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 333.74 E-value: 2.01e-110
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| dpiB | PRK15053 | sensor histidine kinase DpiB; Provisional |
3-522 | 3.46e-57 | ||||||||
sensor histidine kinase DpiB; Provisional Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 199.67 E-value: 3.46e-57
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| NtrY | COG5000 | Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
191-522 | 2.35e-35 | ||||||||
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 137.02 E-value: 2.35e-35
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| HATPase_DpiB-CitA-like | cd16915 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-522 | 1.22e-31 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain. Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 117.77 E-value: 1.22e-31
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| KdpD | COG2205 | K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
314-522 | 1.84e-26 | ||||||||
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 107.69 E-value: 1.84e-26
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| HATPase_c | smart00387 | Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
421-522 | 7.85e-25 | ||||||||
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 98.88 E-value: 7.85e-25
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| NtrB | COG3852 | Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
206-522 | 1.05e-24 | ||||||||
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 105.31 E-value: 1.05e-24
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| BaeS | COG0642 | Signal transduction histidine kinase [Signal transduction mechanisms]; |
213-522 | 4.71e-24 | ||||||||
Signal transduction histidine kinase [Signal transduction mechanisms]; Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 103.06 E-value: 4.71e-24
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| sCache_3_2 | pfam17203 | Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
35-171 | 6.29e-23 | ||||||||
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 94.40 E-value: 6.29e-23
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| WalK | COG5002 | Sensor histidine kinase WalK [Signal transduction mechanisms]; |
220-522 | 8.54e-23 | ||||||||
Sensor histidine kinase WalK [Signal transduction mechanisms]; Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 100.40 E-value: 8.54e-23
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| HATPase | cd00075 | Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
421-521 | 1.43e-22 | ||||||||
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains. Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 92.28 E-value: 1.43e-22
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| HATPase_c | pfam02518 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
420-525 | 4.98e-21 | ||||||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 88.19 E-value: 4.98e-21
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| PRK11360 | PRK11360 | two-component system sensor histidine kinase AtoS; |
213-528 | 4.48e-20 | ||||||||
two-component system sensor histidine kinase AtoS; Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 93.49 E-value: 4.48e-20
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| COG4191 | COG4191 | Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
393-522 | 2.45e-19 | ||||||||
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 89.47 E-value: 2.45e-19
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| HATPase_TmoS-FixL-DctS-like | cd16920 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 9.46e-17 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain. Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 75.90 E-value: 9.46e-17
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| PRK11100 | PRK11100 | sensory histidine kinase CreC; Provisional |
290-524 | 5.77e-16 | ||||||||
sensory histidine kinase CreC; Provisional Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 80.27 E-value: 5.77e-16
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| HATPase_AtoS-like | cd16943 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
419-522 | 2.03e-15 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains. Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.07 E-value: 2.03e-15
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| HATPase_HupT_MifS-like | cd16976 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-521 | 2.80e-15 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain. Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 71.72 E-value: 2.80e-15
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| COG4251 | COG4251 | Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
63-522 | 3.26e-14 | ||||||||
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 75.21 E-value: 3.26e-14
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| HATPase_NtrY-like | cd16944 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 3.73e-13 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains. Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 65.64 E-value: 3.73e-13
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| HATPase_RstB-like | cd16939 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 1.21e-12 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain. Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 63.99 E-value: 1.21e-12
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| KinE | COG5809 | Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
212-524 | 1.22e-12 | ||||||||
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 70.00 E-value: 1.22e-12
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| PRK10604 | PRK10604 | sensor protein RstB; Provisional |
314-524 | 2.08e-12 | ||||||||
sensor protein RstB; Provisional Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 68.86 E-value: 2.08e-12
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| HATPase_BasS-like | cd16940 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-521 | 2.11e-12 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain. Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 63.58 E-value: 2.11e-12
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| HATPase_TutC-TodS-like | cd16925 | Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
424-522 | 2.42e-12 | ||||||||
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain. Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 63.67 E-value: 2.42e-12
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| PRK10364 | PRK10364 | two-component system sensor histidine kinase ZraS; |
393-527 | 2.99e-12 | ||||||||
two-component system sensor histidine kinase ZraS; Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 68.66 E-value: 2.99e-12
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| HATPase_AgrC-ComD-like | cd16935 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-512 | 7.08e-12 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence. Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 62.98 E-value: 7.08e-12
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| KinA | COG5805 | Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
427-522 | 8.89e-12 | ||||||||
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 67.45 E-value: 8.89e-12
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| HATPase_EnvZ-like | cd16950 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 1.09e-11 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain. Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 61.31 E-value: 1.09e-11
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| cztS_silS_copS | TIGR01386 | heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
396-522 | 5.85e-11 | ||||||||
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 64.72 E-value: 5.85e-11
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| HATPase_PhoQ-like | cd16954 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
420-521 | 9.96e-11 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain. Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 59.57 E-value: 9.96e-11
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| HATPase_VanS-like | cd16923 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 1.02e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain. Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 58.55 E-value: 1.02e-10
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| HATPase_CpxA-like | cd16949 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
427-522 | 1.10e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain. Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 58.49 E-value: 1.10e-10
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| HATPase_Glnl-NtrB-like | cd16918 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-522 | 2.14e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s). Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 57.80 E-value: 2.14e-10
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| HATPase_BvrS-ChvG-like | cd16953 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-522 | 2.55e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain. Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.58 E-value: 2.55e-10
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| HATPase_BaeS-like | cd16946 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-522 | 4.64e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain. Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 57.09 E-value: 4.64e-10
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| HATPase_EvgS-ArcB-TorS-like | cd16922 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
424-522 | 9.14e-10 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain. Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 55.96 E-value: 9.14e-10
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| envZ | PRK09467 | osmolarity sensor protein; Provisional |
424-522 | 1.49e-09 | ||||||||
osmolarity sensor protein; Provisional Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 59.92 E-value: 1.49e-09
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| HATPase_FilI-like | cd16921 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
424-522 | 6.26e-09 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain. Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.48 E-value: 6.26e-09
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| HATPase_CheA-like | cd16916 | Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
401-522 | 1.26e-08 | ||||||||
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain. Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 54.51 E-value: 1.26e-08
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| YesM | COG2972 | Sensor histidine kinase YesM [Signal transduction mechanisms]; |
312-526 | 1.64e-08 | ||||||||
Sensor histidine kinase YesM [Signal transduction mechanisms]; Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 56.95 E-value: 1.64e-08
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| HATPase_c_5 | pfam14501 | GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
420-519 | 5.56e-08 | ||||||||
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 50.68 E-value: 5.56e-08
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| cpxA | PRK09470 | envelope stress sensor histidine kinase CpxA; |
421-522 | 8.96e-08 | ||||||||
envelope stress sensor histidine kinase CpxA; Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 54.55 E-value: 8.96e-08
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| PRK10549 | PRK10549 | two-component system sensor histidine kinase BaeS; |
427-522 | 2.17e-07 | ||||||||
two-component system sensor histidine kinase BaeS; Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 53.48 E-value: 2.17e-07
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| HATPase_CreC-like | cd16945 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
425-514 | 2.22e-07 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS. Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.38 E-value: 2.22e-07
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| HATPase_EcPhoR-like | cd16952 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-524 | 2.33e-07 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism. Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 49.12 E-value: 2.33e-07
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| KinB | COG5806 | Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
427-523 | 2.34e-07 | ||||||||
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 52.95 E-value: 2.34e-07
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| phoR | PRK11006 | phosphate regulon sensor histidine kinase PhoR; |
421-525 | 5.40e-07 | ||||||||
phosphate regulon sensor histidine kinase PhoR; Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 51.93 E-value: 5.40e-07
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| PRK10337 | PRK10337 | sensor protein QseC; Provisional |
314-520 | 6.43e-07 | ||||||||
sensor protein QseC; Provisional Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 51.96 E-value: 6.43e-07
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| RocR | COG3829 | RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
206-337 | 7.71e-07 | ||||||||
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]; Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 51.70 E-value: 7.71e-07
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| PRK09835 | PRK09835 | Cu(+)/Ag(+) sensor histidine kinase; |
394-524 | 1.13e-06 | ||||||||
Cu(+)/Ag(+) sensor histidine kinase; Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 50.93 E-value: 1.13e-06
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| PRK10490 | PRK10490 | sensor protein KdpD; Provisional |
413-522 | 3.29e-06 | ||||||||
sensor protein KdpD; Provisional Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 50.03 E-value: 3.29e-06
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| RsbW | COG2172 | Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
419-513 | 3.80e-06 | ||||||||
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 46.06 E-value: 3.80e-06
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| PRK10815 | PRK10815 | two-component system sensor histidine kinase PhoQ; |
399-519 | 6.44e-06 | ||||||||
two-component system sensor histidine kinase PhoQ; Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 48.86 E-value: 6.44e-06
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| PRK13837 | PRK13837 | two-component system VirA-like sensor kinase; |
419-524 | 6.52e-06 | ||||||||
two-component system VirA-like sensor kinase; Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 48.91 E-value: 6.52e-06
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| HATPase_RsbW-like | cd16936 | Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
421-513 | 1.58e-05 | ||||||||
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B. Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 43.41 E-value: 1.58e-05
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| PRK10755 | PRK10755 | two-component system sensor histidine kinase PmrB; |
314-528 | 2.16e-05 | ||||||||
two-component system sensor histidine kinase PmrB; Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 46.88 E-value: 2.16e-05
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| PksD | COG3321 | Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
137-512 | 4.36e-05 | ||||||||
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 46.40 E-value: 4.36e-05
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| PRK13557 | PRK13557 | histidine kinase; Provisional |
355-521 | 6.73e-05 | ||||||||
histidine kinase; Provisional Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 45.43 E-value: 6.73e-05
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| PRK09303 | PRK09303 | histidine kinase; |
424-522 | 8.77e-05 | ||||||||
histidine kinase; Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 44.94 E-value: 8.77e-05
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| ComP | COG4585 | Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
442-522 | 1.07e-04 | ||||||||
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.84 E-value: 1.07e-04
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| COG3920 | COG3920 | Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
35-522 | 1.68e-04 | ||||||||
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms]; Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.13 E-value: 1.68e-04
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| PRK09959 | PRK09959 | acid-sensing system histidine kinase EvgS; |
424-525 | 2.93e-04 | ||||||||
acid-sensing system histidine kinase EvgS; Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 43.95 E-value: 2.93e-04
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| PRK04184 | PRK04184 | DNA topoisomerase VI subunit B; Validated |
417-476 | 3.73e-04 | ||||||||
DNA topoisomerase VI subunit B; Validated Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 42.96 E-value: 3.73e-04
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| PRK10841 | PRK10841 | two-component system sensor histidine kinase RcsC; |
449-522 | 4.14e-04 | ||||||||
two-component system sensor histidine kinase RcsC; Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 43.04 E-value: 4.14e-04
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| HATPase_UhpB-NarQ-NarX-like | cd16917 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
443-522 | 5.51e-04 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains. Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.07 E-value: 5.51e-04
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| HATPase_CckA-like | cd16919 | Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
427-522 | 7.00e-04 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s). Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 39.29 E-value: 7.00e-04
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| COG4192 | COG4192 | Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
424-504 | 7.84e-04 | ||||||||
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 42.37 E-value: 7.84e-04
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| PRK11466 | PRK11466 | hybrid sensory histidine kinase TorS; Provisional |
424-527 | 8.53e-04 | ||||||||
hybrid sensory histidine kinase TorS; Provisional Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 42.20 E-value: 8.53e-04
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| HATPase_SpaK_NisK-like | cd16975 | Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
421-520 | 5.61e-03 | ||||||||
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals. Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 36.67 E-value: 5.61e-03
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