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Conserved domains on  [gi|2495360856|ref|WP_279655831|]
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MULTISPECIES: cupin domain-containing protein [unclassified Agrobacterium]

Protein Classification

cupin domain-containing protein( domain architecture ID 10007541)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFF1 COG3542
Predicted sugar epimerase, cupin superfamily [General function prediction only];
6-143 6.33e-75

Predicted sugar epimerase, cupin superfamily [General function prediction only];


:

Pssm-ID: 442763  Cd Length: 149  Bit Score: 219.66  E-value: 6.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   6 SAQAIIRELGLEPHPEGGFYHQTFRDR-------AGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLS 78
Cdd:COG3542     4 TAEELIEKLGLEPHPEGGYYRETYRSAeripaaaLGGGRAASTAIYFLLTAGEFSHWHRV-DSDEIWHFYAGDPLELHLI 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495360856  79 QDGREVQTFTLGPAILEGERPQVIVPANCWQSAESLG--DFTLVGCTVSPGFAFSSFVMAEPGWSPG 143
Cdd:COG3542    83 HPDGTYETVVLGPDLAAGQRPQLVVPAGTWQAARLLGggGYALVGCTVAPGFDFEDFELAPRDELLA 149
 
Name Accession Description Interval E-value
CFF1 COG3542
Predicted sugar epimerase, cupin superfamily [General function prediction only];
6-143 6.33e-75

Predicted sugar epimerase, cupin superfamily [General function prediction only];


Pssm-ID: 442763  Cd Length: 149  Bit Score: 219.66  E-value: 6.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   6 SAQAIIRELGLEPHPEGGFYHQTFRDR-------AGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLS 78
Cdd:COG3542     4 TAEELIEKLGLEPHPEGGYYRETYRSAeripaaaLGGGRAASTAIYFLLTAGEFSHWHRV-DSDEIWHFYAGDPLELHLI 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495360856  79 QDGREVQTFTLGPAILEGERPQVIVPANCWQSAESLG--DFTLVGCTVSPGFAFSSFVMAEPGWSPG 143
Cdd:COG3542    83 HPDGTYETVVLGPDLAAGQRPQLVVPAGTWQAARLLGggGYALVGCTVAPGFDFEDFELAPRDELLA 149
Cupin_5 pfam06172
Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and ...
 8-135 5.18e-64

Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.


Pssm-ID: 461843  Cd Length: 139  Bit Score: 191.96  E-value: 5.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   8 QAIIRELGLEPHPEGGFYHQTFRD---------RAGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLS 78
Cdd:pfam06172   1 QELIAKLGLEPHPEGGYFRETYRSpetipspdlDYGGPRSASTAIYFLLTAGPFSAFHRV-DSDEVWHFHAGAPLELHLI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856  79 -QDGREVQTFTLGPAILEGERPQVIVPANCWQSAESLGD--FTLVGCTVSPGFAFSSFVM 135
Cdd:pfam06172  80 hPDDGSVETVVLGPDLAAGERPQVVVPAGVWQAARLLGDdgYSLVSCTVAPGFDFEDFEL 139
cupin_YML079wp cd06121
Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes ...
 7-140 7.27e-64

Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380376  Cd Length: 153  Bit Score: 191.99  E-value: 7.27e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   7 AQAIIRELGLEPHPEGGFYHQTFRD-------RAGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLSQ 79
Cdd:cd06121     1 AEELIEKLGLEPHPEGGYFRETYRSpetvptpRDGGERPASTAIYYLLTPGDFSAFHRL-KSDEIWHFHAGDPLELHLLD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2495360856  80 DGREVQTFTLGPAILEGERPQVIVPANCWQSAESLGD--FTLVGCTVSPGFAFSSFVMAEPGW 140
Cdd:cd06121    80 PDGTYETVVLGPDLAAGERPQVVVPAGTWQAAELLGGggYALVGCTVAPGFDFEDFELGDREE 142
 
Name Accession Description Interval E-value
CFF1 COG3542
Predicted sugar epimerase, cupin superfamily [General function prediction only];
6-143 6.33e-75

Predicted sugar epimerase, cupin superfamily [General function prediction only];


Pssm-ID: 442763  Cd Length: 149  Bit Score: 219.66  E-value: 6.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   6 SAQAIIRELGLEPHPEGGFYHQTFRDR-------AGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLS 78
Cdd:COG3542     4 TAEELIEKLGLEPHPEGGYYRETYRSAeripaaaLGGGRAASTAIYFLLTAGEFSHWHRV-DSDEIWHFYAGDPLELHLI 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2495360856  79 QDGREVQTFTLGPAILEGERPQVIVPANCWQSAESLG--DFTLVGCTVSPGFAFSSFVMAEPGWSPG 143
Cdd:COG3542    83 HPDGTYETVVLGPDLAAGQRPQLVVPAGTWQAARLLGggGYALVGCTVAPGFDFEDFELAPRDELLA 149
Cupin_5 pfam06172
Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and ...
 8-135 5.18e-64

Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.


Pssm-ID: 461843  Cd Length: 139  Bit Score: 191.96  E-value: 5.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   8 QAIIRELGLEPHPEGGFYHQTFRD---------RAGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLS 78
Cdd:pfam06172   1 QELIAKLGLEPHPEGGYFRETYRSpetipspdlDYGGPRSASTAIYFLLTAGPFSAFHRV-DSDEVWHFHAGAPLELHLI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856  79 -QDGREVQTFTLGPAILEGERPQVIVPANCWQSAESLGD--FTLVGCTVSPGFAFSSFVM 135
Cdd:pfam06172  80 hPDDGSVETVVLGPDLAAGERPQVVVPAGVWQAARLLGDdgYSLVSCTVAPGFDFEDFEL 139
cupin_YML079wp cd06121
Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes ...
 7-140 7.27e-64

Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380376  Cd Length: 153  Bit Score: 191.99  E-value: 7.27e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856   7 AQAIIRELGLEPHPEGGFYHQTFRD-------RAGGERGHSTAIYYLLEKGDRSHWHRVtDAVEVWHYYAGAPIALHLSQ 79
Cdd:cd06121     1 AEELIEKLGLEPHPEGGYFRETYRSpetvptpRDGGERPASTAIYYLLTPGDFSAFHRL-KSDEIWHFHAGDPLELHLLD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2495360856  80 DGREVQTFTLGPAILEGERPQVIVPANCWQSAESLGD--FTLVGCTVSPGFAFSSFVMAEPGW 140
Cdd:cd06121    80 PDGTYETVVLGPDLAAGERPQVVVPAGTWQAAELLGGggYALVGCTVAPGFDFEDFELGDREE 142
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 10-128 1.29e-04

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 38.65  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360856  10 IIRELglePHPEggfyhqtfrdrAGGERGHSTAiYYLLEKGDRSHWHRVTDAVEVWHYYAGAPIaLHLsqDGrevQTFTL 89
Cdd:cd02214     4 LIREL---LHPD-----------NDGDPRYSLA-HARVPPGESTLPHRLKGSEEVYYILEGEGT-MEI--DG---EPREV 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2495360856  90 GPAILegerpqVIVPANCWQSAESLGDFTLVG-CTVSPGF 128
Cdd:cd02214    63 GPGDA------VLIPPGAVQRIENTGEEDLVFlCICSPAW 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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