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MULTISPECIES: NADP-dependent malic enzyme [unclassified Agrobacterium]
Protein Classification
NADP-dependent malic enzyme ( domain architecture ID 11482649 )
NADP-dependent malic enzyme catalyzes the conversion of (S)-malate to pyruvate and carbon dioxide using NADP as a cofactor
List of domain hits
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
13-761
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1359.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 13 SVTD Q E ALD F H AEG RPGK L E I TPTKP M ATQRDLSLAYSPGVA V P VKA IA EN PA T AY D YT T RGN M VAVISNGTA I LGLGN L 92
Cdd:PRK07232 1 EQLK Q A ALD Y H RFP RPGK I E V TPTKP L ATQRDLSLAYSPGVA A P CLE IA KD PA D AY K YT A RGN L VAVISNGTA V LGLGN I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 93 GALASKPVMEGK S VLFK R FA DV D SI D L EVD T ED A D E FI NC V RY L G P S FGGINLEDIKAPECF I IE SR LRE L MDIPVFHDD 172
Cdd:PRK07232 81 GALASKPVMEGK G VLFK K FA GI D VF D I EVD E ED P D K FI EA V AA L E P T FGGINLEDIKAPECF Y IE EK LRE R MDIPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QHGTAII A AA G L I NA I EL T G RDFKTT K L V CN GAGAAAIAC MD L IK A M G FNP ENI TL CD T KGVIY Q GRTEGM NQ WK S A H AV 252
Cdd:PRK07232 161 QHGTAII S AA A L L NA L EL V G KKIEDV K I V VS GAGAAAIAC LN L LV A L G AKK ENI IV CD S KGVIY K GRTEGM DE WK A A Y AV 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 K TD N RTLAEA MK GADV VF GLS QK G AF T E EM IR SMA PK PIIFA M ANPDPEITPEE VSRI R D DAI M ATGRSDYPNQVNNVL G 332
Cdd:PRK07232 241 D TD A RTLAEA IE GADV FL GLS AA G VL T P EM VK SMA DN PIIFA L ANPDPEITPEE AKAV R P DAI I ATGRSDYPNQVNNVL C 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 333 FPYIFRGALDV R A RQ IN DA MK I AA AQ A L A D LARE D V P D D VAAAY Q G NRPR FG SQ YIIP V PFDPRLI SA I PV AVA R AA IET 412
Cdd:PRK07232 321 FPYIFRGALDV G A TT IN EE MK L AA VR A I A E LARE E V S D E VAAAY G G QKLS FG PE YIIP K PFDPRLI VK I AP AVA K AA MDS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 413 GVA Q R ELP D L DAY ARE L S A RRDPMASTTQRLYERVRRS PKRVVFAE A EEE Q V M RAA ISFTAQ GL GTA IL L GR DDI I K A NA 492
Cdd:PRK07232 401 GVA T R PIA D M DAY REK L E A FVYKTGLVMKPIFAKAKKD PKRVVFAE G EEE R V L RAA QEVVDE GL AKP IL I GR PEV I E A RI 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 493 ERA G I DL DR - ANI EI T N ARLSS R VDA Y VD Y L Y AR LQR G G FLLR D VQ RL IHN DR NHFA A C MVA M GDADA VVT G V T RN Y STA 571
Cdd:PRK07232 481 KKL G L DL KA g VDF EI V N PEDDP R YEE Y WQ Y Y Y EL LQR K G VTPE D AR RL VRR DR TVIG A M MVA R GDADA MIC G L T GR Y HEH 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 572 L EDI R RC I NTK PG - H RVIGVSLVVSRNRTV F V ADT A V HDM P N AE D LA D IA EE AA HLA RRFG Y EPRVA M L AY S T FG QPTGE 650
Cdd:PRK07232 561 L RPV R QV I GLR PG v H TAAAMNALLLKGGNL F I ADT Y V NED P T AE E LA E IA LM AA EEV RRFG I EPRVA L L SH S N FG SSDSP 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 651 RSD K V REAV KI L DK R NVNF EVDGEM SA D V ALN HHRMQSQ YPF A RL S GPANVLVMP AIHS A S IS TKM L Q ELGG ATV IGP L L 730
Cdd:PRK07232 641 SAR K M REAV EL L RE R APDL EVDGEM HG D A ALN EEIRKDL YPF S RL K GPANVLVMP NLEA A N IS YNL L K ELGG GVT IGP I L 720
730 740 750
....*....|....*....|....*....|.
gi 2495360888 731 V G LD K S V Q I A T MG A KDSD IVNM A A I A AYN A G 761
Cdd:PRK07232 721 L G MA K P V H I L T PS A TVRR IVNM T A L A VVD A Q 751
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
13-761
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1359.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 13 SVTD Q E ALD F H AEG RPGK L E I TPTKP M ATQRDLSLAYSPGVA V P VKA IA EN PA T AY D YT T RGN M VAVISNGTA I LGLGN L 92
Cdd:PRK07232 1 EQLK Q A ALD Y H RFP RPGK I E V TPTKP L ATQRDLSLAYSPGVA A P CLE IA KD PA D AY K YT A RGN L VAVISNGTA V LGLGN I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 93 GALASKPVMEGK S VLFK R FA DV D SI D L EVD T ED A D E FI NC V RY L G P S FGGINLEDIKAPECF I IE SR LRE L MDIPVFHDD 172
Cdd:PRK07232 81 GALASKPVMEGK G VLFK K FA GI D VF D I EVD E ED P D K FI EA V AA L E P T FGGINLEDIKAPECF Y IE EK LRE R MDIPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QHGTAII A AA G L I NA I EL T G RDFKTT K L V CN GAGAAAIAC MD L IK A M G FNP ENI TL CD T KGVIY Q GRTEGM NQ WK S A H AV 252
Cdd:PRK07232 161 QHGTAII S AA A L L NA L EL V G KKIEDV K I V VS GAGAAAIAC LN L LV A L G AKK ENI IV CD S KGVIY K GRTEGM DE WK A A Y AV 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 K TD N RTLAEA MK GADV VF GLS QK G AF T E EM IR SMA PK PIIFA M ANPDPEITPEE VSRI R D DAI M ATGRSDYPNQVNNVL G 332
Cdd:PRK07232 241 D TD A RTLAEA IE GADV FL GLS AA G VL T P EM VK SMA DN PIIFA L ANPDPEITPEE AKAV R P DAI I ATGRSDYPNQVNNVL C 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 333 FPYIFRGALDV R A RQ IN DA MK I AA AQ A L A D LARE D V P D D VAAAY Q G NRPR FG SQ YIIP V PFDPRLI SA I PV AVA R AA IET 412
Cdd:PRK07232 321 FPYIFRGALDV G A TT IN EE MK L AA VR A I A E LARE E V S D E VAAAY G G QKLS FG PE YIIP K PFDPRLI VK I AP AVA K AA MDS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 413 GVA Q R ELP D L DAY ARE L S A RRDPMASTTQRLYERVRRS PKRVVFAE A EEE Q V M RAA ISFTAQ GL GTA IL L GR DDI I K A NA 492
Cdd:PRK07232 401 GVA T R PIA D M DAY REK L E A FVYKTGLVMKPIFAKAKKD PKRVVFAE G EEE R V L RAA QEVVDE GL AKP IL I GR PEV I E A RI 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 493 ERA G I DL DR - ANI EI T N ARLSS R VDA Y VD Y L Y AR LQR G G FLLR D VQ RL IHN DR NHFA A C MVA M GDADA VVT G V T RN Y STA 571
Cdd:PRK07232 481 KKL G L DL KA g VDF EI V N PEDDP R YEE Y WQ Y Y Y EL LQR K G VTPE D AR RL VRR DR TVIG A M MVA R GDADA MIC G L T GR Y HEH 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 572 L EDI R RC I NTK PG - H RVIGVSLVVSRNRTV F V ADT A V HDM P N AE D LA D IA EE AA HLA RRFG Y EPRVA M L AY S T FG QPTGE 650
Cdd:PRK07232 561 L RPV R QV I GLR PG v H TAAAMNALLLKGGNL F I ADT Y V NED P T AE E LA E IA LM AA EEV RRFG I EPRVA L L SH S N FG SSDSP 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 651 RSD K V REAV KI L DK R NVNF EVDGEM SA D V ALN HHRMQSQ YPF A RL S GPANVLVMP AIHS A S IS TKM L Q ELGG ATV IGP L L 730
Cdd:PRK07232 641 SAR K M REAV EL L RE R APDL EVDGEM HG D A ALN EEIRKDL YPF S RL K GPANVLVMP NLEA A N IS YNL L K ELGG GVT IGP I L 720
730 740 750
....*....|....*....|....*....|.
gi 2495360888 731 V G LD K S V Q I A T MG A KDSD IVNM A A I A AYN A G 761
Cdd:PRK07232 721 L G MA K P V H I L T PS A TVRR IVNM T A L A VVD A Q 751
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
11-432
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 682.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 11 R TSVTD QEAL DF H AEGRP GK LEIT PT K P MA TQ R DLSLAY S PGVA VPVKA IAE N P AT AY D YT TR GN M VAV ISN GTA I LGLG 90
Cdd:COG0281 5 R VETLE QEAL EY H RIYDR GK ILVY PT V P LH TQ E DLSLAY T PGVA EACLE IAE D P RL AY G YT AK GN L VAV VTD GTA V LGLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 91 NL G A LA SK PVMEGK S VLFK R FA DV D SIDLEV DT E D A DEF INC V RY L G P S FGGINLEDIKAP E CF I IE S RLRE LM DIPVFH 170
Cdd:COG0281 85 DI G P LA GM PVMEGK A VLFK A FA GI D AFPICL DT N D P DEF VEA V KA L E P T FGGINLEDIKAP N CF E IE E RLRE EL DIPVFH 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 171 DDQHGTAI IAA A G L I NA IE L T G RDFKTT K L V C NGAGAA A IA CMD L IK A M G FNP ENI TLC D T KG VI Y Q GRT e GM N QW K SAH 250
Cdd:COG0281 165 DDQHGTAI VVL A A L L NA LK L V G KKLEDQ K I V I NGAGAA G IA IAR L LV A A G LSE ENI IMV D S KG LL Y E GRT - DL N PY K REF 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 251 A VK T DN R ---- TLAEA M KGADV VF G L S QK GAFTEEM IR SMA PK PIIFA M ANP D PEITPE EVSRIR D D AI M ATGRSDYPNQ 326
Cdd:COG0281 244 A RD T NP R glkg TLAEA I KGADV FI G V S AP GAFTEEM VK SMA KR PIIFA L ANP T PEITPE DAKAWG D G AI V ATGRSDYPNQ 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 327 VNNVL G FP Y IFRGALDVRA RQ I N D A MK I aaaqaladlaredvpddv AAA Y ---- QGNRPRF G SQ YIIP V PFDPR LIS A IP 402
Cdd:COG0281 324 VNNVL I FP G IFRGALDVRA TR I T D E MK L ------------------ AAA R alad LVDEEEL G PD YIIP S PFDPR VSP A VA 385
410 420 430
....*....|....*....|....*....|
gi 2495360888 403 V AVA R AAIE T GVA Q R ELP dl DA Y ARE L S AR 432
Cdd:COG0281 386 A AVA K AAIE S GVA R R PID -- ED Y REA L E AR 413
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
439-757
1.60e-114
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 348.92
E-value: 1.60e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 439 TTQ R LY ER VRRSP KR V VF A E A E E E Q V MR AA ISFTA QG LGTA IL L G rd D I I KAN A ERA G I DLD RAN IEI TNARL S S R VDA Y 518
Cdd:pfam01515 1 FLE R IF ER AKKAK KR I VF P E G E D E R V LK AA QKLLQ QG IADP IL I G -- D E I EIK A KAL G L DLD LDG IEI VDPET S P R LEE Y 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 519 V D YL Y ARLQ R G G FLLRDVQRLI h N D R N H FAA CM V AM G D AD AV V T G VTRNYSTA L EDIRRC I N TKPG HRVI - G V SLVVSRN 597
Cdd:pfam01515 79 A D FY Y ELRK R K G MTPEIAREIV - R D P N Y FAA ML V KL G E AD GM V S G AVNTTADT L RPALQI I G TKPG VKTV s S V FIMLLPD 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 598 RTV F V AD T AV HDM P N AE D LA D IA EEA A HL A R RFG - Y EPRVA M L A YSTFG QPT GE RSD KVREA V KI LDK R NVNFE VDGE MS 676
Cdd:pfam01515 158 GLL F F AD C AV NPN P T AE E LA E IA LMS A KT A K RFG i I EPRVA L L S YSTFG SGK GE DVE KVREA T KI VRE R APDLV VDGE LQ 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 677 A D V AL NHHRMQSQY P FARLS G P ANV L V M P AIHSAS I ST K ML Q E LGGA TV IGP L L V GL D K S V QIATM GA KDS DIVN M AAI A 756
Cdd:pfam01515 238 F D A AL VEEVAAQKA P DSPVA G K ANV F V F P DLEAGN I GY K IA Q R LGGA EA IGP I L Q GL A K P V NDLSR GA SVE DIVN T AAI T 317
.
gi 2495360888 757 A 757
Cdd:pfam01515 318 A 318
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
173-410
9.01e-111
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 335.92
E-value: 9.01e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 Q H GTAI IAA AGL I NA IEL TG RDFKTTKL V C NGAGAA A I ACMD L IK A M G FNPE NI T L C D T KG VIYQ GR TEGM N QW K SAH A V 252
Cdd:smart00919 1 Q Q GTAI VVL AGL L NA LKI TG KKLEDQRI V V NGAGAA G I GIAK L LV A A G VKRK NI W L V D S KG LLTK GR EDNL N PY K KPF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 KT DN R --- TL A EA M KGADV VF G L S - QK GAFTEEM IR SMA PK PIIFA MA NP D PEI T P EEVSRI R - DD AI M ATGRSDYPNQV 327
Cdd:smart00919 81 KT NE R etg TL E EA V KGADV LI G V S g PG GAFTEEM VK SMA ER PIIFA LS NP T PEI E P TAADAY R w TA AI V ATGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 328 NNVL G FP Y IF R GALDVRAR Q I N D A MK I A aaqaladlared VPDDV A A A YQGNRPRF G SQ YIIP V PFD P R LISAIP VAVA R 407
Cdd:smart00919 161 NNVL I FP G IF L GALDVRAR R I T D E MK L A ------------ AAEAL A D A VPVSEEEL G PG YIIP S PFD R R VSARVA VAVA K 228
...
gi 2495360888 408 AAI 410
Cdd:smart00919 229 AAI 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
173-409
6.40e-97
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 299.95
E-value: 6.40e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QHGTAI IAA AGL I NA IE L T G RDFKTT K L V C NGAGAA A IA CMD L IK A M G FN PENI TLC D T KGVIY Q GR TEGM N QW K SAH A V 252
Cdd:cd05311 1 QHGTAI VTL AGL L NA LK L V G KKIEEV K I V I NGAGAA G IA IAR L LL A A G AK PENI VVV D S KGVIY E GR EDDL N PD K NEI A K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 K T DNR ---- TL A EA M KGADV VF G L S QK G AFTE EMI RS MA PK PI I FA M ANP D PEI T PEE VSRIRD D a I M ATGRSD Y PNQVN 328
Cdd:cd05311 81 E T NPE ktgg TL K EA L KGADV FI G V S RP G VVKK EMI KK MA KD PI V FA L ANP V PEI W PEE AKEAGA D - I V ATGRSD F PNQVN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 329 NVLGFP Y IFRGALDVRA RQ I NDA MK I AAA Q A L ADLA R E D V P ddvaaayqgnrprf G SQ YIIP V PFDPR LISAIPV AVA R A 408
Cdd:cd05311 160 NVLGFP G IFRGALDVRA TK I TEE MK L AAA E A I ADLA E E E V L -------------- G EE YIIP T PFDPR VVPRVAT AVA K A 225
.
gi 2495360888 409 A 409
Cdd:cd05311 226 A 226
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
13-761
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1359.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 13 SVTD Q E ALD F H AEG RPGK L E I TPTKP M ATQRDLSLAYSPGVA V P VKA IA EN PA T AY D YT T RGN M VAVISNGTA I LGLGN L 92
Cdd:PRK07232 1 EQLK Q A ALD Y H RFP RPGK I E V TPTKP L ATQRDLSLAYSPGVA A P CLE IA KD PA D AY K YT A RGN L VAVISNGTA V LGLGN I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 93 GALASKPVMEGK S VLFK R FA DV D SI D L EVD T ED A D E FI NC V RY L G P S FGGINLEDIKAPECF I IE SR LRE L MDIPVFHDD 172
Cdd:PRK07232 81 GALASKPVMEGK G VLFK K FA GI D VF D I EVD E ED P D K FI EA V AA L E P T FGGINLEDIKAPECF Y IE EK LRE R MDIPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QHGTAII A AA G L I NA I EL T G RDFKTT K L V CN GAGAAAIAC MD L IK A M G FNP ENI TL CD T KGVIY Q GRTEGM NQ WK S A H AV 252
Cdd:PRK07232 161 QHGTAII S AA A L L NA L EL V G KKIEDV K I V VS GAGAAAIAC LN L LV A L G AKK ENI IV CD S KGVIY K GRTEGM DE WK A A Y AV 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 K TD N RTLAEA MK GADV VF GLS QK G AF T E EM IR SMA PK PIIFA M ANPDPEITPEE VSRI R D DAI M ATGRSDYPNQVNNVL G 332
Cdd:PRK07232 241 D TD A RTLAEA IE GADV FL GLS AA G VL T P EM VK SMA DN PIIFA L ANPDPEITPEE AKAV R P DAI I ATGRSDYPNQVNNVL C 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 333 FPYIFRGALDV R A RQ IN DA MK I AA AQ A L A D LARE D V P D D VAAAY Q G NRPR FG SQ YIIP V PFDPRLI SA I PV AVA R AA IET 412
Cdd:PRK07232 321 FPYIFRGALDV G A TT IN EE MK L AA VR A I A E LARE E V S D E VAAAY G G QKLS FG PE YIIP K PFDPRLI VK I AP AVA K AA MDS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 413 GVA Q R ELP D L DAY ARE L S A RRDPMASTTQRLYERVRRS PKRVVFAE A EEE Q V M RAA ISFTAQ GL GTA IL L GR DDI I K A NA 492
Cdd:PRK07232 401 GVA T R PIA D M DAY REK L E A FVYKTGLVMKPIFAKAKKD PKRVVFAE G EEE R V L RAA QEVVDE GL AKP IL I GR PEV I E A RI 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 493 ERA G I DL DR - ANI EI T N ARLSS R VDA Y VD Y L Y AR LQR G G FLLR D VQ RL IHN DR NHFA A C MVA M GDADA VVT G V T RN Y STA 571
Cdd:PRK07232 481 KKL G L DL KA g VDF EI V N PEDDP R YEE Y WQ Y Y Y EL LQR K G VTPE D AR RL VRR DR TVIG A M MVA R GDADA MIC G L T GR Y HEH 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 572 L EDI R RC I NTK PG - H RVIGVSLVVSRNRTV F V ADT A V HDM P N AE D LA D IA EE AA HLA RRFG Y EPRVA M L AY S T FG QPTGE 650
Cdd:PRK07232 561 L RPV R QV I GLR PG v H TAAAMNALLLKGGNL F I ADT Y V NED P T AE E LA E IA LM AA EEV RRFG I EPRVA L L SH S N FG SSDSP 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 651 RSD K V REAV KI L DK R NVNF EVDGEM SA D V ALN HHRMQSQ YPF A RL S GPANVLVMP AIHS A S IS TKM L Q ELGG ATV IGP L L 730
Cdd:PRK07232 641 SAR K M REAV EL L RE R APDL EVDGEM HG D A ALN EEIRKDL YPF S RL K GPANVLVMP NLEA A N IS YNL L K ELGG GVT IGP I L 720
730 740 750
....*....|....*....|....*....|.
gi 2495360888 731 V G LD K S V Q I A T MG A KDSD IVNM A A I A AYN A G 761
Cdd:PRK07232 721 L G MA K P V H I L T PS A TVRR IVNM T A L A VVD A Q 751
PRK12862
PRK12862 malic enzyme; Reviewed
1-762
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1097.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 1 M SD TTKP A ST R tsvtd QE ALD F H AEGR PGK L EI T PTKP M A T QRDL S LAYSPGVA V P VKA IA EN PA T A YD YT T RGN M VAV I 80
Cdd:PRK12862 2 S SD ASAK A EL R ----- EA ALD Y H RFPT PGK I EI A PTKP L A N QRDL A LAYSPGVA A P CLE IA AD PA N A AR YT S RGN L VAV V 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 81 SNGTA I LGLGN L G A LASKPVMEGK S VLFK R FA DV D SI D L E V D TE D A D EFINC V RY L G P S FGGINLEDIKAPECF I IE SR L 160
Cdd:PRK12862 77 SNGTA V LGLGN I G P LASKPVMEGK A VLFK K FA GI D VF D I E L D ES D P D KLVEI V AA L E P T FGGINLEDIKAPECF Y IE RE L 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 161 RE L M D IPVFHDDQHGTAII A AA G L I N AIE L T G R D FKTT KLV CN GAGAAA I AC M DL IKAM G FNP ENI TLC D T KGV I Y Q GRT 240
Cdd:PRK12862 157 RE R M K IPVFHDDQHGTAII V AA A L L N GLK L V G K D IEDV KLV AS GAGAAA L AC L DL LVSL G VKR ENI WVT D I KGV V Y E GRT 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 241 E G M NQ WK SAH A V KTD N RTLAE AMK GADV VF GLS QK G AFTE EM IRS MAP K P I IFA M ANP D PEI T PEE VSRI R D DAI M ATGR 320
Cdd:PRK12862 237 E L M DP WK ARY A Q KTD A RTLAE VIE GADV FL GLS AA G VLKP EM VKK MAP R P L IFA L ANP T PEI L PEE ARAV R P DAI I ATGR 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 321 SDYPNQVNNVL G FPYIFRGALDV R A RQ IN DA MKIAA AQ A L A D LARE DVP D D VAAAY Q G NRPR FG SQ Y I IP V PFDPRLI SA 400
Cdd:PRK12862 317 SDYPNQVNNVL C FPYIFRGALDV G A TT IN EE MKIAA VR A I A E LARE EQS D V VAAAY G G EDLS FG PD Y L IP K PFDPRLI LK 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 401 I PV AVA R AA IET GVA Q R ELP D L DAY ARE L SARRDPMASTTQRLYERVRRS PKRVVFAE A E E E Q V M RAA ISFTAQ GL GTA I 480
Cdd:PRK12862 397 I AP AVA Q AA MDS GVA T R PIE D M DAY REQ L NQFVYHSGLIMKPVFAAAKAA PKRVVFAE G E D E R V L RAA QVVVDE GL AKP I 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 481 L L GR DDI I K A NA ERAG ID L - DRANI EI T N ARLSS R VDA Y V D YLY A RLQ R G G FLLRDVQ R LIHNDRNHFA A C MV AM G D ADA 559
Cdd:PRK12862 477 L I GR PAV I E A RI ERAG LR L r PGVDF EI V N PEDDP R YRD Y W D TYH A LMG R K G VTPEMAR R EVRRRTTLIG A M MV KR G E ADA 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 560 VVT G VTRN Y STA LE DIRRC I NTK PG H RV I - GV SL VVSRN RT V F V ADT A V HDM P N AE D LA D I AEE AA HLA RRFG Y EP R VA M 638
Cdd:PRK12862 557 MIC G TEGR Y ERH LE FVLQV I GKR PG V RV Y a AM SL LILPG RT L F L ADT H V NED P T AE E LA E I TIL AA EEV RRFG I EP K VA L 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 639 L AY S T FG QPTGERSD K V REA VK IL DK R NVNF EVDGEM SA D V AL NHHRMQSQY P FA RL S G P AN V LV M P AIHS A S I STKM L Q 718
Cdd:PRK12862 637 L SH S N FG SSDSPSAR K M REA LE IL RE R APDL EVDGEM HG D A AL DEELRDRIF P DS RL E G E AN L LV F P NLDA A N I AYNL L K 716
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 2495360888 719 ELG G ATV - I GP L L V G LD K S V Q I A T MG A KDSD IVNM A A I A AYN A GR 762
Cdd:PRK12862 717 TAA G NGL a V GP I L L G AA K P V H I L T PS A TVRR IVNM T A L A VAD A NA 761
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
11-432
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 682.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 11 R TSVTD QEAL DF H AEGRP GK LEIT PT K P MA TQ R DLSLAY S PGVA VPVKA IAE N P AT AY D YT TR GN M VAV ISN GTA I LGLG 90
Cdd:COG0281 5 R VETLE QEAL EY H RIYDR GK ILVY PT V P LH TQ E DLSLAY T PGVA EACLE IAE D P RL AY G YT AK GN L VAV VTD GTA V LGLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 91 NL G A LA SK PVMEGK S VLFK R FA DV D SIDLEV DT E D A DEF INC V RY L G P S FGGINLEDIKAP E CF I IE S RLRE LM DIPVFH 170
Cdd:COG0281 85 DI G P LA GM PVMEGK A VLFK A FA GI D AFPICL DT N D P DEF VEA V KA L E P T FGGINLEDIKAP N CF E IE E RLRE EL DIPVFH 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 171 DDQHGTAI IAA A G L I NA IE L T G RDFKTT K L V C NGAGAA A IA CMD L IK A M G FNP ENI TLC D T KG VI Y Q GRT e GM N QW K SAH 250
Cdd:COG0281 165 DDQHGTAI VVL A A L L NA LK L V G KKLEDQ K I V I NGAGAA G IA IAR L LV A A G LSE ENI IMV D S KG LL Y E GRT - DL N PY K REF 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 251 A VK T DN R ---- TLAEA M KGADV VF G L S QK GAFTEEM IR SMA PK PIIFA M ANP D PEITPE EVSRIR D D AI M ATGRSDYPNQ 326
Cdd:COG0281 244 A RD T NP R glkg TLAEA I KGADV FI G V S AP GAFTEEM VK SMA KR PIIFA L ANP T PEITPE DAKAWG D G AI V ATGRSDYPNQ 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 327 VNNVL G FP Y IFRGALDVRA RQ I N D A MK I aaaqaladlaredvpddv AAA Y ---- QGNRPRF G SQ YIIP V PFDPR LIS A IP 402
Cdd:COG0281 324 VNNVL I FP G IFRGALDVRA TR I T D E MK L ------------------ AAA R alad LVDEEEL G PD YIIP S PFDPR VSP A VA 385
410 420 430
....*....|....*....|....*....|
gi 2495360888 403 V AVA R AAIE T GVA Q R ELP dl DA Y ARE L S AR 432
Cdd:COG0281 386 A AVA K AAIE S GVA R R PID -- ED Y REA L E AR 413
PRK12861
PRK12861 malic enzyme; Reviewed
12-762
0e+00
malic enzyme; Reviewed
Pssm-ID: 183798 [Multi-domain]
Cd Length: 764
Bit Score: 680.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 12 T SVTD Q E ALD F H AEGR PGK LEITPT KP MA TQRDL S LAY S PGVA VPVKA IA EN P AT A YDY T T RGN M V A VI S NGTA I LGLGN 91
Cdd:PRK12861 4 T ETQR Q A ALD Y H EFPT PGK ISVVAS KP LV TQRDL A LAY T PGVA SACEE IA AD P LN A FRF T S RGN L V G VI T NGTA V LGLGN 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 92 L GALASKPVMEGK S VLFK R FA DV D SI D L E VDTE D A D EFINCVRY L G P S FGGINLEDIKAPECF II E SR LRE L M D IPVFHD 171
Cdd:PRK12861 84 I GALASKPVMEGK A VLFK K FA GI D VF D I E INET D P D KLVDIIAG L E P T FGGINLEDIKAPECF TV E RK LRE R M K IPVFHD 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 172 DQHGTAI IAA A GL IN AIELT G RDF K TT K L V CN GAGAAA I AC M DL IKAM G FNP ENI TLC D TK GV I Y Q GRT EG M NQW K SAH A 251
Cdd:PRK12861 164 DQHGTAI TVS A AF IN GLKVV G KSI K EV K V V TS GAGAAA L AC L DL LVDL G LPV ENI WVT D IE GV V Y R GRT TL M DPD K ERF A 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 252 VK TD N RTLAE AMK GADV VF GLS QK G AFTE EM IRS MA PK P I I F A M ANP D PEI T PE EVSRI RDD AIM ATGRSDYPNQVNNVL 331
Cdd:PRK12861 244 QE TD A RTLAE VIG GADV FL GLS AG G VLKA EM LKA MA AR P L I L A L ANP T PEI F PE LAHAT RDD VVI ATGRSDYPNQVNNVL 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 332 G FPYIFRGALDV R A RQ I NDA M K IAA AQ A L A D LA R E DVP D D VAAAY QGNRPR FG S QY I IP V PFDPRLI SA I PV AVA R AA I E 411
Cdd:PRK12861 324 C FPYIFRGALDV G A TT I TRE M E IAA VH A I A G LA E E EQN D V VAAAY GAYDVS FG P QY L IP K PFDPRLI VR I AP AVA K AA M E 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 412 T GVA Q R ELP DLDAY ARE L S ------- A RRD P MASTTQR L yer VR RSP K - R V VF A E A E E E Q V M RA AISFTAQG L GTA IL L G 483
Cdd:PRK12861 404 G GVA T R PIA DLDAY VEQ L Q qfvyhsg A FMK P LFAAARQ L --- VR DGG K a R I VF T E G E D E R V L RA VQVIVDEK L ARP IL V G 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 484 R DDIIK A NA ER A G ID L DRA - NI E I TN ARLSS R VDA Y VDYLYARLQ R G G f LLRDVQ R LIHND R - NHFA A C MV AM GDAD AVV 561
Cdd:PRK12861 481 R PEVLL A RI ER F G LR L RLG q DV E V TN PEYDE R FPQ Y WTTYWELRC R D G - ISKEMA R VEMRR R l TLIG A M MV RL GDAD GMI 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 562 T G VTRN Y STA L EDIRRC I NT KPG HRVIG - VSLVVSRN RTV FVA DT A V H D M P N AE DL A DIAEE AA HLARRFGYE P R VA M L A 640
Cdd:PRK12861 560 C G TVGE Y HNH L RFVDEV I GR KPG ASTYA a MNILLLDQ RTV ALV DT H V N D N P D AE QI A EFTIA AA RQMEWLNLT P K VA L L S 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 641 Y S T FG QPTGERSD K V R E A VK I LDKRNVNF E V DGEM SA D V AL NHHRMQSQY P FAR L S G P AN V LV M P AIHSAS I STKM L QEL 720
Cdd:PRK12861 640 R S N FG SGSAASGV K M R R A LE I VREQAPDL E A DGEM HG D C AL DEGLRARLL P MSP L K G A AN L LV C P NVDAGN I AYNL L KTE 719
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 2495360888 721 G G AT V - I GP L L V G LDKS V Q I A T MG A KDSD IVNMAA IAAYN A G R 762
Cdd:PRK12861 720 A G SN V a V GP F L L G VNAP V N I L T SS A TVRR IVNMAA LTVIE A N R 762
Pta
COG0280 Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production ...
441-757
3.43e-129
Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production and conversion];
Pssm-ID: 440049 [Multi-domain]
Cd Length: 320
Bit Score: 386.73
E-value: 3.43e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 441 QR L Y ER VRRS PKR V VFAE A E E E Q V M RAA ISFTAQ GL GTA IL L GR DDI I K A N AE RA G I DL D ra NI EI TNARL S S R VDA Y VD 520
Cdd:COG0280 4 RP L I ER AKAA PKR I VFAE G E D E R V L RAA QEALDE GL AEP IL V GR PEK I E A R AE EL G L DL S -- GF EI IDPED S P R YEE Y AE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 521 YL Y ARLQ R G G FLLRDVQR L IH n D RNH FAA C MV AM G D AD AV V T G VTRNYSTA L EDIRRC I NTK PG HRVI - G V S L VVSRN R T 599
Cdd:COG0280 82 AY Y ELRK R K G VTPEEARE L VR - D AAY FAA M MV RL G E AD GL V K G AVGTTADL L RPVLQI I GLR PG VKRV s H V F L MELPD R L 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 600 V F VA DTAV HDM P N AE D LADIA EE AA HL AR R FG Y EP R VA M L AY S T FG Q P T G ERS DKVREA V K ILDKRNVNF EVDGE MSA D V 679
Cdd:COG0280 161 L F IT DTAV NID P T AE Q LADIA IN AA DT AR A FG I EP K VA L L SA S E FG S P K G PST DKVREA T K MARGQIPDL EVDGE LQF D A 240
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2495360888 680 AL NHHRMQSQY P FARLS G P ANVLV M P AIHSAS I ST K M LQ E L G GA TV IGP L L V GL D K S V QIATM G AKDS DIVN MA A I AA 757
Cdd:COG0280 241 AL SPEAAKRKG P DSPVA G D ANVLV F P DLEAGN I LY K L LQ R L A GA EA IGP I L L GL A K P V HLLSR G DSVR DIVN SI A L AA 318
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
439-757
1.60e-114
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 348.92
E-value: 1.60e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 439 TTQ R LY ER VRRSP KR V VF A E A E E E Q V MR AA ISFTA QG LGTA IL L G rd D I I KAN A ERA G I DLD RAN IEI TNARL S S R VDA Y 518
Cdd:pfam01515 1 FLE R IF ER AKKAK KR I VF P E G E D E R V LK AA QKLLQ QG IADP IL I G -- D E I EIK A KAL G L DLD LDG IEI VDPET S P R LEE Y 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 519 V D YL Y ARLQ R G G FLLRDVQRLI h N D R N H FAA CM V AM G D AD AV V T G VTRNYSTA L EDIRRC I N TKPG HRVI - G V SLVVSRN 597
Cdd:pfam01515 79 A D FY Y ELRK R K G MTPEIAREIV - R D P N Y FAA ML V KL G E AD GM V S G AVNTTADT L RPALQI I G TKPG VKTV s S V FIMLLPD 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 598 RTV F V AD T AV HDM P N AE D LA D IA EEA A HL A R RFG - Y EPRVA M L A YSTFG QPT GE RSD KVREA V KI LDK R NVNFE VDGE MS 676
Cdd:pfam01515 158 GLL F F AD C AV NPN P T AE E LA E IA LMS A KT A K RFG i I EPRVA L L S YSTFG SGK GE DVE KVREA T KI VRE R APDLV VDGE LQ 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 677 A D V AL NHHRMQSQY P FARLS G P ANV L V M P AIHSAS I ST K ML Q E LGGA TV IGP L L V GL D K S V QIATM GA KDS DIVN M AAI A 756
Cdd:pfam01515 238 F D A AL VEEVAAQKA P DSPVA G K ANV F V F P DLEAGN I GY K IA Q R LGGA EA IGP I L Q GL A K P V NDLSR GA SVE DIVN T AAI T 317
.
gi 2495360888 757 A 757
Cdd:pfam01515 318 A 318
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
173-410
9.01e-111
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 335.92
E-value: 9.01e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 Q H GTAI IAA AGL I NA IEL TG RDFKTTKL V C NGAGAA A I ACMD L IK A M G FNPE NI T L C D T KG VIYQ GR TEGM N QW K SAH A V 252
Cdd:smart00919 1 Q Q GTAI VVL AGL L NA LKI TG KKLEDQRI V V NGAGAA G I GIAK L LV A A G VKRK NI W L V D S KG LLTK GR EDNL N PY K KPF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 KT DN R --- TL A EA M KGADV VF G L S - QK GAFTEEM IR SMA PK PIIFA MA NP D PEI T P EEVSRI R - DD AI M ATGRSDYPNQV 327
Cdd:smart00919 81 KT NE R etg TL E EA V KGADV LI G V S g PG GAFTEEM VK SMA ER PIIFA LS NP T PEI E P TAADAY R w TA AI V ATGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 328 NNVL G FP Y IF R GALDVRAR Q I N D A MK I A aaqaladlared VPDDV A A A YQGNRPRF G SQ YIIP V PFD P R LISAIP VAVA R 407
Cdd:smart00919 161 NNVL I FP G IF L GALDVRAR R I T D E MK L A ------------ AAEAL A D A VPVSEEEL G PG YIIP S PFD R R VSARVA VAVA K 228
...
gi 2495360888 408 AAI 410
Cdd:smart00919 229 AAI 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
173-409
6.40e-97
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 299.95
E-value: 6.40e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QHGTAI IAA AGL I NA IE L T G RDFKTT K L V C NGAGAA A IA CMD L IK A M G FN PENI TLC D T KGVIY Q GR TEGM N QW K SAH A V 252
Cdd:cd05311 1 QHGTAI VTL AGL L NA LK L V G KKIEEV K I V I NGAGAA G IA IAR L LL A A G AK PENI VVV D S KGVIY E GR EDDL N PD K NEI A K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 253 K T DNR ---- TL A EA M KGADV VF G L S QK G AFTE EMI RS MA PK PI I FA M ANP D PEI T PEE VSRIRD D a I M ATGRSD Y PNQVN 328
Cdd:cd05311 81 E T NPE ktgg TL K EA L KGADV FI G V S RP G VVKK EMI KK MA KD PI V FA L ANP V PEI W PEE AKEAGA D - I V ATGRSD F PNQVN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 329 NVLGFP Y IFRGALDVRA RQ I NDA MK I AAA Q A L ADLA R E D V P ddvaaayqgnrprf G SQ YIIP V PFDPR LISAIPV AVA R A 408
Cdd:cd05311 160 NVLGFP G IFRGALDVRA TK I TEE MK L AAA E A I ADLA E E E V L -------------- G EE YIIP T PFDPR VVPRVAT AVA K A 225
.
gi 2495360888 409 A 409
Cdd:cd05311 226 A 226
eutD
PRK09653 phosphotransacetylase;
441-757
8.33e-68
phosphotransacetylase;
Pssm-ID: 236609 [Multi-domain]
Cd Length: 324
Bit Score: 226.65
E-value: 8.33e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 441 QR L Y E RVRRSP K RV V FA E A E E E Q V MR AA ISFTAQ GL GTA ILLG RDDI I K A N A ERA G I DLD ra NI EI TNARLSSRVDAYVD 520
Cdd:PRK09653 5 ES L K E KAKGKK K KI V LP E G E D E R V LK AA KRLQKE GL VEP ILLG NPEE I R A K A KEL G L DLD -- GV EI IDPETYPLLEEFAE 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 521 YLYAR lq R G G FLLRDVQRLIHN D R N H F AACM V AM G D AD AV V T G V tr NY STA le D IR R ---- C I N TKPG HRVI - G V SLV V S 595
Cdd:PRK09653 83 AFVEL -- R K G KGTEEDAAELLK D P N Y F GTML V KL G K AD GM V S G A -- IH STA -- D TL R palq I I K TKPG VKTV s S V FIM V K 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 596 RNRTVFV AD T AV HDM P N AE D LA D IA EEA A HL A RR FG YE P R VAML AY ST F G QPT G ERS DKV R EA VK I LDKRNVNFEV DGE M 675
Cdd:PRK09653 157 GDERYIF AD C AV NPN P T AE Q LA E IA INS A ET A KA FG ID P K VAML SF ST K G SAK G PEV DKV Q EA TE I AKELAPDLKI DGE L 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 676 SA D V A LNHHRMQSQY P FARLS G P ANV L V M P AIHSAS I ST K ML Q E LGG ATVI GP L L V GL D K S V QIATM G AKDS DI V N M A A I 755
Cdd:PRK09653 237 QF D A A FVPEVAAKKA P GSPVA G K ANV F V F P SLEAGN I GY K IA Q R LGG FEAV GP I L Q GL N K P V NDLSR G CSVE DI Y N L A L I 316
..
gi 2495360888 756 A A 757
Cdd:PRK09653 317 T A 318
malic
pfam00390 Malic enzyme, N-terminal domain;
28-161
5.46e-40
Malic enzyme, N-terminal domain;
Pssm-ID: 395314 [Multi-domain]
Cd Length: 182
Bit Score: 145.48
E-value: 5.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 28 P GK L E ITPT K PMA T Q -- R DL SLA Y S P G V AVPVK AI A E NPATAY - D YT TR GN M ---------------- V A V ISN G TA ILG 88
Cdd:pfam00390 1 Q GK N E VLFY K LLS T H ie E DL PIV Y T P T V GEACQ AI S E IYRRPR g L YT SI GN L gkikdilknwpeedvr V I V VTD G ER ILG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 89 LG N LG A l A SK P V MEGK SV L FKR FA DV D --- SIDLEV D T --------------------------- E DA DEF INC V RY L G P 138
Cdd:pfam00390 81 LG D LG V - A GM P I MEGK LA L YTA FA GI D psr VLPIVL D V gtnnekllndplylglrhkrvrgeeyd E FV DEF VEA V KA L F P 159
170 180
....*....|....*....|...
gi 2495360888 139 S FGGI NL ED IK AP EC F I I ES R L R 161
Cdd:pfam00390 160 P FGGI QF ED FG AP NA F E I LE R Y R 182
PRK05632
PRK05632 phosphate acetyltransferase; Reviewed
442-757
6.25e-37
phosphate acetyltransferase; Reviewed
Pssm-ID: 235537 [Multi-domain]
Cd Length: 684
Bit Score: 147.99
E-value: 6.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 442 R L Y ER V R RSP KR V V FA E AE E EQVMR AA ISFTAQ G LGTAI LLG RDDI I KAN A ERA G I DL D r A N IEI TNARLSS rv DA YV D y 521
Cdd:PRK05632 368 Q L T ER A R AAK KR I V LP E GD E PRTLK AA AICLER G IADCV LLG NPEE I RRV A AAQ G V DL P - A G IEI IDPSEVR -- ER YV A - 443
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 522 LYAR L QRGGFLLRD V Q R LIHN D RNH F AAC M V A M G DA D AV V T G VT rn YS TA ------ L ED I R rcin T K PG hrvig V SLV V S 595
Cdd:PRK05632 444 PLVE L RKHKGMTEE V A R EQLE D NVY F GTM M L A L G EV D GL V S G AV -- HT TA ntirpa L QL I K ---- T A PG ----- S SLV S S 512
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 596 rnrt VF V ---------- A D T AV HDM P N AE D LA D IA EEA A HL A RR FG Y EPRVAML A YST FGQPT G ERSD KVREA VKILDK R 665
Cdd:PRK05632 513 ---- VF F mllpdqvlvy G D C AV NPD P T AE Q LA E IA IQS A DS A AA FG I EPRVAML S YST GTSGS G ADVE KVREA TRLARE R 588
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 666 NVNFEV DG EMSA D V A LNHHRMQ S QY P FARLS G P A N V LVM P AIHSASIST K ML Q ELG GA TV IGP L L V GL D K S V QIATM GA K 745
Cdd:PRK05632 589 RPDLLI DG PLQY D A A VDPSVAR S KA P NSPVA G R A T V FIF P DLNTGNTTY K AV Q RSA GA VS IGP M L Q GL R K P V NDLSR GA L 668
330
....*....|..
gi 2495360888 746 DS DIVN MA AI A A 757
Cdd:PRK05632 669 VD DIVN TI AI T A 680
PTZ00317
PTZ00317 NADP-dependent malic enzyme; Provisional
77-428
9.00e-34
NADP-dependent malic enzyme; Provisional
Pssm-ID: 240357 [Multi-domain]
Cd Length: 559
Bit Score: 137.06
E-value: 9.00e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 77 V A VI SN G TA ILGLG N LGA l ASKPVME GK SV L FKRFADVD ------- SI D LEVDT E D ----------------------- A 126
Cdd:PTZ00317 151 V I VI TD G SR ILGLG D LGA - NGMGISI GK LS L YVAGGGIN psrvlpv VL D VGTNN E K llndplylglrekrldddeyyel L 229
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 127 DEF INC V RYLG P S f GGINL ED IKAPE CF IIES R LREL md IPV F H DD QH GT AIIA AAG LI NA IE L T G RDFKTTKL V CN GAG 206
Cdd:PTZ00317 230 DEF MEA V SSRW P N - AVVQF ED FSNNH CF DLLE R YQNK -- YRC F N DD IQ GT GAVI AAG FL NA LK L S G VPPEEQRI V FF GAG 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 207 A AAI ACMDL I KAM ---- G FNP E ---- NIT L C D T KG VIYQG R TEGMNQW K SAH A v K TD ------- NR TL AEAMKGA -- DVV 269
Cdd:PTZ00317 307 S AAI GVANN I ADL aaey G VTR E ealk SFY L V D S KG LVTTT R GDKLAKH K VPF A - R TD isaedss LK TL EDVVRFV kp TAL 385
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 270 F GLS - QK G A FTEE MIRS MA --- PK PIIF AMA NP -- DP E I T P E EVSRIRD - D AI M A T G ---------- RSDY P N Q V NN VLG 332
Cdd:PTZ00317 386 L GLS g VG G V FTEE VVKT MA snv ER PIIF PLS NP ts KA E C T A E DAYKWTN g R AI V A S G spfppvtlng KTIQ P S Q G NN LYV 465
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 333 FP YIFR G ALDVRARQ I N D A M K IAAA QA LA D L ared V PDDVAAAYQ gnrprfgsqy II P VPF D P R L ISA - I P V A V ARA A I E 411
Cdd:PTZ00317 466 FP GVGL G CAIAQPSY I P D E M L IAAA AS LA T L ---- V SEEDLREGK ---------- LY P PLE D I R E ISA h I A V D V IEE A Q E 531
410 420
....*....|....*....|..
gi 2495360888 412 T G V A QREL ----- PD L D A YARE 428
Cdd:PTZ00317 532 M G I A KNKD lpdnr DE L L A LVKD 553
PLN03129
PLN03129 NADP-dependent malic enzyme; Provisional
77-440
1.73e-33
NADP-dependent malic enzyme; Provisional
Pssm-ID: 215594 [Multi-domain]
Cd Length: 581
Bit Score: 136.20
E-value: 1.73e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 77 V A V ISN G TA ILGLG N LG ALA skpv M --- E GK SV L FKRFADVD ------- S ID LEVDT E D --------------------- 125
Cdd:PLN03129 174 V I V VTD G ER ILGLG D LG VQG ---- M gip V GK LD L YTAAGGIR psavlpv C ID VGTNN E K llndpfyiglrqprltgeeyd 249
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 126 -- A DEF INC V -- R Y l GP SFG g INL ED IKAPEC F IIES R L R E lm DIPV F H DD QH GTA II A A AGL IN A IEL TG R D FKTTKLV 201
Cdd:PLN03129 250 el V DEF MEA V kq R W - GP KVL - VQF ED FANKNA F RLLQ R Y R T -- THLC F N DD IQ GTA AV A L AGL LA A LRA TG G D LADQRIL 325
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 202 CN GAG A A AIACMD LI ----- KAM G FNP E ---- N I T L C D T KG VIYQG R TEGMNQW K S -- AH AVK t DNRT L A EA M K GA -- D V 268
Cdd:PLN03129 326 FA GAG E A GTGIAE LI alams RQT G ISE E eark R I W L V D S KG LVTKS R KDSLQPF K K pf AH DHE - PGAS L L EA V K AI kp T V 404
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 269 VF GLS - QK G A FT E E MIRS MA --- PK PIIFA MA NP -- DP E I T P EE VSRIRDD - AI M A T ---------- G RSDY P N Q V NN VL 331
Cdd:PLN03129 405 LI GLS g VG G T FT K E VLEA MA sln ER PIIFA LS NP ts KA E C T A EE AYTWTGG r AI F A S gspfdpveyn G KTFH P G Q A NN AY 484
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 332 G FP Y I FR GAL DVR A RQIN D A M KI AAA Q A - L A DLAR E DV pd DVA A A Y qgnr P R F GS qy I ipvpfdp R L ISA - IPV AVA RA A 409
Cdd:PLN03129 485 I FP G I GL GAL LSG A IRVT D D M LL AAA E A l A A QVTE E EL -- AKG A I Y ---- P P F SR -- I ------- R D ISA h VAA AVA AK A 549
410 420 430
....*....|....*....|....*....|...
gi 2495360888 410 I E T G V A Q R EL -- P DL DA YA R el S ARRD P MASTT 440
Cdd:PLN03129 550 Y E E G L A T R LP rp E DL VE YA E -- S CMYS P VYRPY 580
NAD_bind_1_malic_enz
cd05312 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the ...
175-428
1.14e-31
NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists of eukaryotic and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133454
Cd Length: 279
Bit Score: 124.97
E-value: 1.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 175 GTA II A A AGL IN A IEL TG RDFKTTKLVCN GAG A A A I ---- ACMDLIKAM G FNP E ---- N I T L C D T KG VIYQG R --- T EGM 243
Cdd:cd05312 3 GTA AV A L AGL LA A LRI TG KPLSDQRILFL GAG S A G I giad LIVSAMVRE G LSE E eark K I W L V D S KG LLTKD R kdl T PFK 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 244 NQWKSAHAV K t DNRT L A E AM K -- GAD V VF GLS - QK GAFTEE MI R S MA --- PK PIIFA MA NP DP -- E I T P E EVSRIR D - D A 314
Cdd:cd05312 83 KPFARKDEE K - EGKS L L E VV K av KPT V LI GLS g VG GAFTEE VV R A MA ksn ER PIIFA LS NP TS ka E C T A E DAYKWT D g R A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 315 IM A T G ---------- RSDY P N Q V NN VLG FP Y I FR GA LDVR AR Q I N D A M KI AAA Q ALA dlar ED V P D DVA A ay Q G N rprfg 384
Cdd:cd05312 162 LF A S G spfppveyng KTYV P G Q G NN AYI FP G I GL GA ILSG AR H I T D E M FL AAA E ALA ---- SL V T D EEL A -- R G R ----- 230
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2495360888 385 sqy II P VPFDP R L ISA - I P VAVA RA A I E T G V A Q R EL P -- DL DA Y ARE 428
Cdd:cd05312 231 --- LY P PLSNI R E ISA q I A VAVA KY A Y E E G L A T R YP P pe DL EE Y VKS 274
PRK13529
PRK13529 oxaloacetate-decarboxylating malate dehydrogenase;
165-421
2.68e-28
oxaloacetate-decarboxylating malate dehydrogenase;
Pssm-ID: 237414 [Multi-domain]
Cd Length: 563
Bit Score: 120.24
E-value: 2.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 165 D I PV F H DD QH GT AIIAA AGL IN A IEL TG RDFKTTKL V CN GAG A A AIACM D L I - K AM --- G FNP E ---- NITLC D TK G VIY 236
Cdd:PRK13529 263 E I CT F N DD IQ GT GAVTL AGL LA A LKI TG EPLSDQRI V FL GAG S A GCGIA D Q I v A AM vre G LSE E eark RFFMV D RQ G LLT 342
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 237 QGRT ------------- E GMNQ W KSAH avkt D NRT L A E AMKGA -- D V VF G L S - Q K GAFTEE MIRS MA --- PK PIIF AMA N 297
Cdd:PRK13529 343 DDMP dlldfqkpyarkr E ELAD W DTEG ---- D VIS L L E VVRNV kp T V LI G V S g Q P GAFTEE IVKE MA ahc ER PIIF PLS N 418
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 298 P DP -- E I TPE EVSRIR D - D A IM ATG ---------- RSDYPN Q V NN VLG FP YIFR G ALDVR AR QIN D A M KI aaaqaladla 364
Cdd:PRK13529 419 P TS ra E A TPE DLIAWT D g R A LV ATG spfapveyng KTYPIG Q C NN AYI FP GLGL G VIASG AR RVT D G M LM ---------- 488
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2495360888 365 redvpddv AAA Y ------ QGNR P RF G S qy II P VPF D P R LI S - AI PV AVA R AAIE T G V A QRELPD 421
Cdd:PRK13529 489 -------- AAA H aladcv PLAK P GE G A -- LL P PVE D I R EV S r AI AI AVA K AAIE E G L A RETSDE 542
Malic_M
pfam03949 Malic enzyme, NAD binding domain;
175-352
3.52e-28
Malic enzyme, NAD binding domain;
Pssm-ID: 427608 [Multi-domain]
Cd Length: 257
Bit Score: 114.21
E-value: 3.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 175 GTA II A A AGL IN A IEL TG RDFKTTKL V CN GAG A A A I ACM D L I K ---- AM G FNP E ---- N I TLC D TK G VIYQG R --- T EGM 243
Cdd:pfam03949 3 GTA AV A L AGL LA A LKI TG KPLSEQRI V FF GAG S A G I GIA D Q I R damv RE G LSE E eark R I WMV D RQ G LLTDD R edl T DFQ 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 244 NQW - KSAHAV K -- T D NR TL A E AMKGA -- D V VF G L S - QK GAFTEE MI R S MA --- PK PIIF AMA NP DP -- E I TPE EVSRIR D 312
Cdd:pfam03949 83 KPF a RKRAEL K gw G D GI TL L E VVRKV kp T V LI G A S g VP GAFTEE IV R A MA aht ER PIIF PLS NP TS ka E A TPE DAYKWT D 162
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2495360888 313 - D A IM ATG ---------- RSDYPN Q V NN VLG FP YIFR GA LDV RAR Q I N D A M 352
Cdd:pfam03949 163 g R A LF ATG spfppveyng KTYHIG Q G NN AYI FP GLGL GA IVS RAR R I T D E M 213
NAD_bind_malic_enz
cd00762 NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid ...
173-350
2.34e-24
NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133442
Cd Length: 254
Bit Score: 103.07
E-value: 2.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 173 QH GTA II A A AGL IN A IEL T GRDFKTT K LVC NGAGAAA IACMD LI KAMGFNP -------- EN I TLC D T KG VIYQG R T E GMN 244
Cdd:cd00762 1 IQ GTA SV A V AGL LA A LKV T KKKISEH K VLF NGAGAAA LGIAN LI V*L*VKE giskeeac KR I W*V D R KG LLVKN R K E TCP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 245 QWKSAHAVKTDN R --- T L AE A MK -- GA D VVF G L S QK G - AFT E E M IR SM A P --- K P I IFA MA NP DP -- E I T P EE VSRIRD - 312
Cdd:cd00762 81 NEYHLARFANPE R esg D L ED A VE aa KP D FLI G V S RV G g AFT P E V IR A* A E ine R P V IFA LS NP TS ka E C T A EE AYTATE g 160
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2495360888 313 D AI M A T G RSD ---------- Y P N Q V NN VLG FP YIFR G ALDV R A R Q I N D 350
Cdd:cd00762 161 R AI F A S G SPF hpvelnggty K P G Q G NN LYI FP GVAL G VILC R I R H I T D 208
PRK05805
PRK05805 phosphate butyryltransferase; Validated
436-756
5.11e-11
phosphate butyryltransferase; Validated
Pssm-ID: 180267
Cd Length: 301
Bit Score: 64.34
E-value: 5.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 436 M ASTTQRLYERVR - RS PK RVVF A E A EE E Q V MR A AISFTAQ G LGT AIL L G RDDI IK AN A ERAGI DL - D RAN I EITNA R LSS 513
Cdd:PRK05805 1 M IKSFDEILSKAK e QP PK TISV A V A QD E P V LE A VKEAKEL G IAN AIL V G DKEK IK EI A KEIDM DL e D FEI I DEKDN R KAA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 514 R vdayvdylyarlqrggfllrdvqrlihndrnh F A ACM V AM G D AD A V VT G VT rny S TA l EDI R RCI N TKP G H R V ------ 587
Cdd:PRK05805 81 L -------------------------------- K A VEL V SS G K AD M V MK G LV --- D TA - NFL R AVL N KEI G L R T gktmsh 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 588 IG V SL V VSRN R TV F VA D T A VHDM P NAEDLA DI AEE A AHL A RRF G Y E - P R VA MLAYSTFGQ P tgersd K VREAV -- KI L D K 664
Cdd:PRK05805 125 VA V FE V PKYD R LL F LT D A A FNIA P DLKEKI DI INN A VTV A HAI G I E n P K VA PICAVEVVN P ------ K MPATL da AL L S K 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 665 RNVNFE ----- VDG EMSA D V AL NHHRMQSQYPFARLS G P A NV L VM P A I HSASIST K M L QELGGAT v I G P LLVG LDKS V q I 739
Cdd:PRK05805 199 MSDRGQ ikgci VDG PLAL D N AL SEEAAKHKGIDGPVA G N A DI L LV P N I EAGNVMY K T L TYFADCK - N G G LLVG TSAP V - V 276
330
....*....|....*..
gi 2495360888 740 A T MG A k DS DIVNMAA IA 756
Cdd:PRK05805 277 L T SR A - DS HETKLNS IA 292
PRK08190
PRK08190 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
441-640
3.21e-05
bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
Pssm-ID: 236180 [Multi-domain]
Cd Length: 466
Bit Score: 47.18
E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 441 Q RL YERV R - RS P K R VVFAEAEEEQVM R A A ISFTAQ GL GTAI L L G RDDI I K A N AE R AG I DL DRAN I E itn ARLS S RVD A yv 519
Cdd:PRK08190 165 E RL LAAA R g LP P L R TAVVHPCDAESL R G A LEAAEA GL IEPV L V G PEAK I R A A AE E AG L DL SGVR I V --- DVPH S HAA A -- 239
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2495360888 520 dyly AR lqrggfllrdvqrlihndrnhf A ACMVAM G DAD A VVT G VTRNYSTALEDIR R CINTKPGH R VIG V SL -- V VSRN 597
Cdd:PRK08190 240 ---- AR ---------------------- A VALARA G EVE A LMK G SLHTDELLSAVVA R DSGLRTER R ISH V FA md V PTYP 293
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2495360888 598 R TVFVA D T A VHDM P NA ED LA DI AEE A AH LA RRF G Y E - P R VA M L A 640
Cdd:PRK08190 294 R PLLIT D A A INIA P TL ED KR DI VQN A ID LA HAL G V E e P K VA I L S 337
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
