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Conserved domains on  [gi|2498334072|ref|WP_280796033|]
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MULTISPECIES: triose-phosphate isomerase [Aurantimicrobium]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-256 9.92e-137

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 384.79  E-value: 9.92e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDaghkYTDVEVSVFPPFTDIRSVQNLVEADKLelAYGAQDVSMHDSGAYT 84
Cdd:COG0149     2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD----LADVEVVVCPPFTYLAAVAEALAGSPI--ALGAQNVHWEDSGAYT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  85 GEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS 164
Cdd:COG0149    76 GEISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 165 QD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGG 242
Cdd:COG0149   156 AEqaANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|....
gi 2498334072 243 ASLDVAEFSSIARF 256
Cdd:COG0149   236 ASLDAEDFLAIVRA 249
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-256 9.92e-137

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 384.79  E-value: 9.92e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDaghkYTDVEVSVFPPFTDIRSVQNLVEADKLelAYGAQDVSMHDSGAYT 84
Cdd:COG0149     2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD----LADVEVVVCPPFTYLAAVAEALAGSPI--ALGAQNVHWEDSGAYT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  85 GEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS 164
Cdd:COG0149    76 GEISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 165 QD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGG 242
Cdd:COG0149   156 AEqaANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|....
gi 2498334072 243 ASLDVAEFSSIARF 256
Cdd:COG0149   236 ASLDAEDFLAIVRA 249
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-259 1.68e-131

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 371.76  E-value: 1.68e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDAghkyTDVEVSVFPPFTDIRSVQNLVEADKLelAYGAQDVSMHDSGAYT 84
Cdd:PRK00042    1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA----DGVEVAVAPPFTALASVKEALKGSNI--KLGAQNVHPEDSGAFT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  85 GEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS 164
Cdd:PRK00042   75 GEISAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 165 QD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQrTRILYGGSVKANNIAGFMRQPNIDGALVGG 242
Cdd:PRK00042  155 AEqfANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGEVAEK-VRILYGGSVKPDNAAELMAQPDIDGALVGG 233

                         250
                  ....*....|....*..
gi 2498334072 243 ASLDVAEFSSIARFQKH 259
Cdd:PRK00042  234 ASLKAEDFLAIVKAAAA 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 7-255 8.71e-117

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 334.12  E-value: 8.71e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   7 PLIAGNWKMNLDHLQAIAFVQKLAWTLKDaghkYTDVEVSVFPPFTDIRSVQNLVEADKLELayGAQDVSMHDSGAYTGE 86
Cdd:cd00311     1 PLVAGNWKMNGTLAEALELAKALNAVLKD----ESGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  87 IPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVSQD 166
Cdd:cd00311    75 ISAEMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 167 AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQrTRILYGGSVKANNIAGFMRQPNIDGALVGGASLD 246
Cdd:cd00311   155 APVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGEVAEK-VRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                  ....*....
gi 2498334072 247 VAEFSSIAR 255
Cdd:cd00311   234 AESFLDIIK 242
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 7-256 2.75e-116

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 332.94  E-value: 2.75e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   7 PLIAGNWKMNLDHLQAIAFVQKLAWTLKDAghkyTDVEVSVFPPFTDIRSVQNLVEAdklELAYGAQDVSMHDSGAYTGE 86
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADE----SGVEVVVAPPFTYLSAVAELLGS---NIKVGAQNVDPEESGAFTGE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  87 IPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVSQD 166
Cdd:pfam00121  74 ISAEMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 167 AE-IVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDaAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASL 245
Cdd:pfam00121 154 QKnLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKE-VAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASL 232

                         250
                  ....*....|.
gi 2498334072 246 DVAEFSSIARF 256
Cdd:pfam00121 233 KAEDFLDIINA 243
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 8-245 2.95e-38

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 133.00  E-value: 2.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   8 LIAGNWKMnldHLQAIAFVQKLAWTLKDAGHKYTDVEVSVFPPFTDIRSVqnlveADKLELAYGAQDVSMHDSGAYTGEI 87
Cdd:TIGR00419   1 LVIGNWKT---YNESRGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMI-----KREVEIPVYAQHVDAVLSGAHTGEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  88 PGGFLKALGCSYVIIGHSERRqyHGENDeiVGNKVKAALKHGVVPVLCVgeteaeleefgpSAVPVAQLKKALEGVsqda 167
Cdd:TIGR00419  73 SAEMLKDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCT------------NNVLTTAAAAALEPD---- 132

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2498334072 168 eiVIAYEPVWAIGTGKVATEEQAEAVCAAIRVAlGEVlgdaaAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASL 245
Cdd:TIGR00419 133 --VVAVEPPELIGTGIPVSPAQPEVVHGSVRAV-KEV-----NESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSL 202
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-256 9.92e-137

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 384.79  E-value: 9.92e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDaghkYTDVEVSVFPPFTDIRSVQNLVEADKLelAYGAQDVSMHDSGAYT 84
Cdd:COG0149     2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD----LADVEVVVCPPFTYLAAVAEALAGSPI--ALGAQNVHWEDSGAYT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  85 GEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS 164
Cdd:COG0149    76 GEISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 165 QD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGG 242
Cdd:COG0149   156 AEqaANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGG 235

                         250
                  ....*....|....
gi 2498334072 243 ASLDVAEFSSIARF 256
Cdd:COG0149   236 ASLDAEDFLAIVRA 249
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-259 1.68e-131

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 371.76  E-value: 1.68e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDAghkyTDVEVSVFPPFTDIRSVQNLVEADKLelAYGAQDVSMHDSGAYT 84
Cdd:PRK00042    1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA----DGVEVAVAPPFTALASVKEALKGSNI--KLGAQNVHPEDSGAFT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  85 GEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS 164
Cdd:PRK00042   75 GEISAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 165 QD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQrTRILYGGSVKANNIAGFMRQPNIDGALVGG 242
Cdd:PRK00042  155 AEqfANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGEVAEK-VRILYGGSVKPDNAAELMAQPDIDGALVGG 233

                         250
                  ....*....|....*..
gi 2498334072 243 ASLDVAEFSSIARFQKH 259
Cdd:PRK00042  234 ASLKAEDFLAIVKAAAA 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 7-255 8.71e-117

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 334.12  E-value: 8.71e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   7 PLIAGNWKMNLDHLQAIAFVQKLAWTLKDaghkYTDVEVSVFPPFTDIRSVQNLVEADKLELayGAQDVSMHDSGAYTGE 86
Cdd:cd00311     1 PLVAGNWKMNGTLAEALELAKALNAVLKD----ESGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  87 IPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVSQD 166
Cdd:cd00311    75 ISAEMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 167 AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQrTRILYGGSVKANNIAGFMRQPNIDGALVGGASLD 246
Cdd:cd00311   155 APVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGEVAEK-VRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                  ....*....
gi 2498334072 247 VAEFSSIAR 255
Cdd:cd00311   234 AESFLDIIK 242
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 7-256 2.75e-116

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 332.94  E-value: 2.75e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   7 PLIAGNWKMNLDHLQAIAFVQKLAWTLKDAghkyTDVEVSVFPPFTDIRSVQNLVEAdklELAYGAQDVSMHDSGAYTGE 86
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADE----SGVEVVVAPPFTYLSAVAELLGS---NIKVGAQNVDPEESGAFTGE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  87 IPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVSQD 166
Cdd:pfam00121  74 ISAEMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 167 AE-IVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDaAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASL 245
Cdd:pfam00121 154 QKnLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKE-VAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASL 232

                         250
                  ....*....|.
gi 2498334072 246 DVAEFSSIARF 256
Cdd:pfam00121 233 KAEDFLDIINA 243
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 3-256 6.44e-109

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 327.84  E-value: 6.44e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   3 NTRTPLIAGNWKMNLDHLQAIAFVQKLAWTLKDAghkytDVEVSVFPPFTDIRSVQNLVEADKLElaYGAQDVSMHDSGA 82
Cdd:PRK13962  395 NPRKPIIAGNWKMNKTPAEAKEFVNELKKYVKDA-----QAEVVVCPPFTALPSVKEAVDGSNIK--LGAQNVFYEEKGA 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  83 YTGEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEG 162
Cdd:PRK13962  468 YTGEISGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNG 547

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 163 VSQD--AEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALV 240
Cdd:PRK13962  548 LSAEqvKKVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLV 627

                         250
                  ....*....|....*.
gi 2498334072 241 GGASLDVAEFSSIARF 256
Cdd:PRK13962  628 GGASLKAQEFAAIANY 643
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 4-260 2.58e-83

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 249.83  E-value: 2.58e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   4 TRTPLIAGNWKMNLdhlqAIAFVQKLAWTLKDAGHKYTDVEVSVFPPFTDIRSVQNLVEADKLELayGAQDVSMHDSGAY 83
Cdd:PTZ00333    3 KRKPFVGGNWKCNG----TKASIKELIDSFNKLKFDPNNVDVVVAPPSLHIPLVQEKLKNKNFKI--SSQNVSLTGSGAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  84 TGEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGV 163
Cdd:PTZ00333   77 TGEISAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 164 SQDAE--IVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVG 241
Cdd:PTZ00333  157 SDEAWdnIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVG 236

                         250
                  ....*....|....*....
gi 2498334072 242 GASLDvAEFSSIARFQKHV 260
Cdd:PTZ00333  237 GASLK-PDFVDIIKSAEQS 254
PLN02561 PLN02561
triosephosphate isomerase
 5-255 4.66e-58

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 185.41  E-value: 4.66e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   5 RTPLIAGNWKMNldhlQAIAFVQKLAWTLKDAGHKYTD-VEVSVFPPFTDIRSVQNLVEADkleLAYGAQDVSMHDSGAY 83
Cdd:PLN02561    3 RKFFVGGNWKCN----GTVEEVKKIVTTLNEAEVPSEDvVEVVVSPPFVFLPLVKSLLRPD---FQVAAQNCWVKKGGAF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  84 TGEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGV 163
Cdd:PLN02561   76 TGEISAEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 164 SQDAEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVALGEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGA 243
Cdd:PLN02561  156 SDWANVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGA 235

                         250
                  ....*....|..
gi 2498334072 244 SLDvAEFSSIAR 255
Cdd:PLN02561  236 SLK-PEFIDIIK 246
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 8-253 4.88e-54

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 174.56  E-value: 4.88e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   8 LIAGNWKMNLDHLQAIAFVQKLAWTLKDAGHkytDVEVSVFPPFTDIRSVQNLVEADKLelayGAQDVSMHDSGAYTGEI 87
Cdd:PRK14565    4 LIVANWKMNGDFSLFSSFLKELSNKLANNEI---TLKLVICPPFTAMSSFVECNPNIKL----GAQNCFYGSSGGYTGEI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  88 PGGFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALegvSQDA 167
Cdd:PRK14565   77 SAKMLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCL---PKHG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 168 EIVIAYEPVWAIGTGKVATEEQAEAVCAAIRvalgevlgdAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASLDV 247
Cdd:PRK14565  154 EFIIAYEPVWAIGGSTIPSNDAIAEAFEIIR---------SYDSKSHIIYGGSVNQENIRDLKSINQLSGVLVGSASLDV 224


                  ....*.
gi 2498334072 248 AEFSSI 253
Cdd:PRK14565  225 DSFCKI 230
PLN02429 PLN02429
triosephosphate isomerase
 42-253 1.62e-49

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 165.35  E-value: 1.62e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  42 DVEVSVFPPFTDIRSVQNLVeADKLELAygAQDVSMHDSGAYTGEIPGGFLKALGCSYVIIGHSERRQYHGENDEIVGNK 121
Cdd:PLN02429   96 DVDVVVSPPFVYIDQVKSSL-TDRIDIS--GQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKK 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 122 VKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVSQDAEIVIAYEPVWAIGTGKVATEEQAEAVCAAIRVAL 201
Cdd:PLN02429  173 AAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWDNIVVAYEPVWAIGTGKVASPQQAQEVHVAVRGWL 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2498334072 202 GEVLGDAAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASLDVAEFSSI 253
Cdd:PLN02429  253 KKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATI 304
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 12-253 1.26e-45

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 153.61  E-value: 1.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  12 NWKMNLDHLQAIAFVQKLAwTLKDAGHKYTDVEVSVFPPFTDIRSVQNLVEA--DKLELAYGAQDVSMHDSGAYTGEIPG 89
Cdd:PRK15492    9 NLKMYKGIADATDFLAKLS-ELADDIPADKDIELFVIPSFTAIQDAIAATLAipHDHPIIIGAQNMNPNDNGQFTGDISP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  90 GFLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETeAELEEFGPS-AVPVAQLKKALEGVSQD-- 166
Cdd:PRK15492   88 LMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGET-LEQKNYGISdEILRTQLKIGLHGINPDql 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 167 AEIVIAYEPVWAIGTGKV-ATEEQAEAVCAAIRVALGEVLGDaAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASL 245
Cdd:PRK15492  167 AKLRIAYEPVWAIGEAGIpASADYADEKHAVIKQCLIELFGD-AGDDIPVFYGGSVNAENANELFGQPHIDGLFIGRSAW 245


                  ....*...
gi 2498334072 246 DVAEFSSI 253
Cdd:PRK15492  246 DADKFFAI 253
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 13-253 9.81e-44

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 151.34  E-value: 9.81e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  13 WKMNLDHLQAIAFVQKLAWTLKDaghKYtDVEVSVFPPFTDIRSVQNLV--EADKLELAYGAQDVSMHDSGAYTGEIPGG 90
Cdd:PRK14905   14 YKGNAETVDYLSELLAFAEKFKS---DY-DIELFVIPSYIALKDAVEAAasETGHPKIKIGAQNMNAKDKGQFTGEISPL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  91 FLKALGCSYVIIGHSERRQYHGENDEIVGNKVKAALKHGVVPVLCVGETEAELEEFGPSAVPVAQLKKALEGVS--QDAE 168
Cdd:PRK14905   90 MLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGLHGVSaeQLPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072 169 IVIAYEPVWAIGTGKV-ATEEQAEAVCAAIRVALGEVLGDaAAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASLDV 247
Cdd:PRK14905  170 LFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAE-ESKKIPVLYGGSVNLENANELIMKPHIDGLFIGRSAWDA 248


                  ....*.
gi 2498334072 248 AEFSSI 253
Cdd:PRK14905  249 QCFHAL 254
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 8-245 2.95e-38

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 133.00  E-value: 2.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072   8 LIAGNWKMnldHLQAIAFVQKLAWTLKDAGHKYTDVEVSVFPPFTDIRSVqnlveADKLELAYGAQDVSMHDSGAYTGEI 87
Cdd:TIGR00419   1 LVIGNWKT---YNESRGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMI-----KREVEIPVYAQHVDAVLSGAHTGEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  88 PGGFLKALGCSYVIIGHSERRqyHGENDeiVGNKVKAALKHGVVPVLCVgeteaeleefgpSAVPVAQLKKALEGVsqda 167
Cdd:TIGR00419  73 SAEMLKDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCT------------NNVLTTAAAAALEPD---- 132

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2498334072 168 eiVIAYEPVWAIGTGKVATEEQAEAVCAAIRVAlGEVlgdaaAQRTRILYGGSVKANNIAGFMRQPNIDGALVGGASL 245
Cdd:TIGR00419 133 --VVAVEPPELIGTGIPVSPAQPEVVHGSVRAV-KEV-----NESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSL 202
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 39-182 2.01e-12

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 64.50  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498334072  39 KYTDVEVSVFPPFTDIRSVqnlveADKLELAYGAQDVSMHDSGAYTGEIPGGFLKALGCSYVIIGHSERRQYHGEndeiV 118
Cdd:PRK04302   33 KETGVRIAVAPQALDIRRV-----AEEVDIPVYAQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTLAD----I 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2498334072 119 GNKVKAALKHGVVPVLCVG--ETEAELEEFGPSAVpvaqlkkalegvsqdaeiviAYEPVWAIGTG 182
Cdd:PRK04302  104 EAVVERAKKLGLESVVCVNnpETSAAAAALGPDYV--------------------AVEPPELIGTG 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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