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Conserved domains on  [gi|2501502270|ref|WP_281509898|]
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MULTISPECIES: type II toxin-antitoxin system YafQ family toxin [Bacteroidales]

Protein Classification

type II toxin-antitoxin system YafQ family toxin( domain architecture ID 11239005)

type II toxin-antitoxin (TA) system YafQ family toxin similar to Escherichia coli YafQ, which functions as a sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis, and is the toxin component of the YafQ-DinJ TA module that plays a role in biofilm formation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YafQ_toxin pfam15738
Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ...
 2-90 1.11e-32

Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, pfam02604.


:

Pssm-ID: 434896  Cd Length: 88  Bit Score: 108.72  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  2 KTLRPSTQYKKDLKRIRNNPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWIdQTTNDIDLVR 81
Cdd:pfam15738  1 YKIKYTKQFKKDYKRAKKRGYDIEKLKEVIDLLAEGEPLPEKYRDHALKGNWKGHRECHIKPDWLLIYR-IDDDELILVR 79


                 ....*....
gi 2501502270 82 LGSHSELFG 90
Cdd:pfam15738 80 TGSHSDLFG 88
 
Name Accession Description Interval E-value
YafQ_toxin pfam15738
Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ...
 2-90 1.11e-32

Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, pfam02604.


Pssm-ID: 434896  Cd Length: 88  Bit Score: 108.72  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  2 KTLRPSTQYKKDLKRIRNNPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWIdQTTNDIDLVR 81
Cdd:pfam15738  1 YKIKYTKQFKKDYKRAKKRGYDIEKLKEVIDLLAEGEPLPEKYRDHALKGNWKGHRECHIKPDWLLIYR-IDDDELILVR 79


                 ....*....
gi 2501502270 82 LGSHSELFG 90
Cdd:pfam15738 80 TGSHSDLFG 88
YafQ COG3041
mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ ...
 1-89 3.03e-32

mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 442275  Cd Length: 88  Bit Score: 107.58  E-value: 3.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  1 MKTLRPSTQYKKDLKRIRNNPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWidQTTND-IDL 79
Cdd:COG3041    1 MLKIVYTKQFKKDLKKLKKRGPDIEKLKKVLRLLAEGNPLPPSLRDHALKGNLKGYRECHINPDWRLIY--RIEDDvLIL 78

                         90
                 ....*....|
gi 2501502270 80 VRLGSHSELF 89
Cdd:COG3041   79 VRIGSHSELF 88
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 7-89 2.08e-17

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 70.03  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  7 STQYKKDLKRIRN-NPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWIDQTTNDIDLVRLGSH 85
Cdd:TIGR02385  5 TEQFKKDLKKIKKyIRKDLPKLLEVIELLINGKPLERRYRDHPLTGSWKGTRECHIEPDYLLVYQVEDEVVIRLVRVGSH 84


                 ....
gi 2501502270 86 SELF 89
Cdd:TIGR02385 85 SQLF 88
 
Name Accession Description Interval E-value
YafQ_toxin pfam15738
Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ...
 2-90 1.11e-32

Bacterial toxin of type II toxin-antitoxin system, YafQ; YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, pfam02604.


Pssm-ID: 434896  Cd Length: 88  Bit Score: 108.72  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  2 KTLRPSTQYKKDLKRIRNNPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWIdQTTNDIDLVR 81
Cdd:pfam15738  1 YKIKYTKQFKKDYKRAKKRGYDIEKLKEVIDLLAEGEPLPEKYRDHALKGNWKGHRECHIKPDWLLIYR-IDDDELILVR 79


                 ....*....
gi 2501502270 82 LGSHSELFG 90
Cdd:pfam15738 80 TGSHSDLFG 88
YafQ COG3041
mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ ...
 1-89 3.03e-32

mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 442275  Cd Length: 88  Bit Score: 107.58  E-value: 3.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  1 MKTLRPSTQYKKDLKRIRNNPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWidQTTND-IDL 79
Cdd:COG3041    1 MLKIVYTKQFKKDLKKLKKRGPDIEKLKKVLRLLAEGNPLPPSLRDHALKGNLKGYRECHINPDWRLIY--RIEDDvLIL 78

                         90
                 ....*....|
gi 2501502270 80 VRLGSHSELF 89
Cdd:COG3041   79 VRIGSHSELF 88
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 7-89 2.08e-17

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 70.03  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502270  7 STQYKKDLKRIRN-NPKKAEALLEVLRLLENELPIPPIYKPHMLTSDYAGCMECHIQGDFLLIWIDQTTNDIDLVRLGSH 85
Cdd:TIGR02385  5 TEQFKKDLKKIKKyIRKDLPKLLEVIELLINGKPLERRYRDHPLTGSWKGTRECHIEPDYLLVYQVEDEVVIRLVRVGSH 84


                 ....
gi 2501502270 86 SELF 89
Cdd:TIGR02385 85 SQLF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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