NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2501502552|ref|WP_281510180|]
View 

MULTISPECIES: response regulator transcription factor [Muribaculum]

Protein Classification

response regulator transcription factor( domain architecture ID 11450879)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; similar to Staphylococcus aureus response regulator VraR

CATH:  1.10.10.10
Gene Ontology:  GO:0000160|GO:0006355|GO:0003677
PubMed:  10966457
SCOP:  3001179

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 192-254 5.25e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 74.93  E-value: 5.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLIH 254
Cdd:COG2197    69 LLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 192-254 5.25e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 74.93  E-value: 5.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLIH 254
Cdd:COG2197    69 LLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 193-244 6.83e-15

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 67.17  E-value: 6.83e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552  193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAV 244
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 193-249 1.25e-14

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 66.40  E-value: 1.25e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFR 249
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
193-244 5.63e-13

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 61.83  E-value: 5.63e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAV 244
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
PRK10360 PRK10360
transcriptional regulator UhpA;
193-250 2.38e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 46.89  E-value: 2.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTaaaVEIGFRM 250
Cdd:PRK10360  138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSND---VELARRM 192
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 193-236 4.14e-03

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 36.94  E-value: 4.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2501502552 193 LSKRQVEILSMLA-KGVGSKQIADKLNISVHTVSRHRQDILSRLR 236
Cdd:TIGR02937 111 LPEREREVLVLRYlEGLSYKEIAEILGISVGTVKRRLKRARKKLR 155
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 192-254 5.25e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 74.93  E-value: 5.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLIH 254
Cdd:COG2197    69 LLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 193-244 6.83e-15

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 67.17  E-value: 6.83e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552  193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAV 244
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 193-249 1.25e-14

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 66.40  E-value: 1.25e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFR 249
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
193-253 1.54e-13

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 67.09  E-value: 1.54e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLI 253
Cdd:COG2771   128 LTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
GerE pfam00196
Bacterial regulatory proteins, luxR family;
193-244 5.63e-13

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 61.83  E-value: 5.63e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAV 244
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 192-253 4.87e-12

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 59.97  E-value: 4.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLI 253
Cdd:COG5905    12 LLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 193-246 1.07e-10

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 59.34  E-value: 1.07e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEI 246
Cdd:COG4566   138 LTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELVRL 191
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
203-254 5.08e-08

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 51.63  E-value: 5.08e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 203 MLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLIH 254
Cdd:COG2909   133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
PRK10360 PRK10360
transcriptional regulator UhpA;
193-250 2.38e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 46.89  E-value: 2.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTaaaVEIGFRM 250
Cdd:PRK10360  138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSND---VELARRM 192
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
192-243 2.80e-06

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 46.77  E-value: 2.80e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAA 243
Cdd:PRK10403  153 VLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
PRK15369 PRK15369
two component system response regulator;
192-253 6.02e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 45.84  E-value: 6.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2501502552 192 LLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAVEIGFRMHLI 253
Cdd:PRK15369  149 LLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
193-239 1.15e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 44.87  E-value: 1.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTN 239
Cdd:PRK09935  150 LSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHS 196
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 162-244 1.41e-04

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 41.94  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502552 162 LAHGLVEGCMTNTRTGKAVDSEqylqydnllLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRL----RV 237
Cdd:PRK10651  134 LTPVLAASLRANRATTERDVNQ---------LTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMklksRV 204


                  ....*..
gi 2501502552 238 tntAAAV 244
Cdd:PRK10651  205 ---EAAV 208
rcsA PRK15411
transcriptional regulator RcsA;
191-239 1.69e-04

transcriptional regulator RcsA;


Pssm-ID: 185309 [Multi-domain]  Cd Length: 207  Bit Score: 41.66  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2501502552 191 LLLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTN 239
Cdd:PRK15411  136 LSLSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHN 184
PRK10100 PRK10100
transcriptional regulator CsgD;
185-244 1.55e-03

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 38.70  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501502552 185 YLQYDNLLLSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAAAV 244
Cdd:PRK10100  148 YNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAV 207
PRK09483 PRK09483
response regulator; Provisional
 193-239 2.60e-03

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 38.16  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTN 239
Cdd:PRK09483  149 LSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISG 195
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 194-236 2.74e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 34.73  E-value: 2.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2501502552 194 SKRQVEILSMLAKG---VGskQIADKLNISVHTVSRHrqdiLSRLR 236
Cdd:pfam01022   1 DPTRLKILKLLAEGelcVC--ELAEELGLSQSTVSHH----LKKLR 40
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 193-236 4.14e-03

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 36.94  E-value: 4.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2501502552 193 LSKRQVEILSMLA-KGVGSKQIADKLNISVHTVSRHRQDILSRLR 236
Cdd:TIGR02937 111 LPEREREVLVLRYlEGLSYKEIAEILGISVGTVKRRLKRARKKLR 155
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 193-242 4.91e-03

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 37.12  E-value: 4.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2501502552 193 LSKRQVEILSMLAKGVGSKQIADKLNISVHTVSRHRQDILSRLRVTNTAA 242
Cdd:PRK10840  151 LSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIA 200
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 193-228 5.40e-03

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 33.84  E-value: 5.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2501502552 193 LSKRQV-EILSMLAKGVGSKQIADKLNISVHTVSRHR 228
Cdd:cd00569     6 LTPEQIaEARRLLAAGESVAEIARELGVSRSTLYRYL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH