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Conserved domains on  [gi|2502538158|ref|WP_281868603|]
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iron ABC transporter permease [Brevibacillus parabrevis]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-330 1.32e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 267.71  E-value: 1.32e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  29 SLFTGVAAIPLQTVLKQ-WSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVV 107
Cdd:COG0609     1 SLSLGAVPISLSDVLRAlLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 108 VLAILFLPSIGSANLIYFAFAGAILGGFTVLGFAS-SRGMTNLKIALVGMAVHLLLTSITKGLIIY--NEHISDVMFWLS 184
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLadPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 185 GSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLM 264
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2502538158 265 IPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARKKG 330
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-330 1.32e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 267.71  E-value: 1.32e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  29 SLFTGVAAIPLQTVLKQ-WSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVV 107
Cdd:COG0609     1 SLSLGAVPISLSDVLRAlLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 108 VLAILFLPSIGSANLIYFAFAGAILGGFTVLGFAS-SRGMTNLKIALVGMAVHLLLTSITKGLIIY--NEHISDVMFWLS 184
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLadPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 185 GSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLM 264
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2502538158 265 IPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARKKG 330
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 21-328 2.11e-78

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 242.05  E-value: 2.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  21 LLAIGLWLSLFTGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVN 100
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 101 AGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSR-GMTNLKIALVGMAVHLLLTSITKGLIIY--NEHIS 177
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRgGASPLRLILAGIAVSALLSALTSLLLLLlnPEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 178 DVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGA 257
Cdd:pfam01032 161 SILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2502538158 258 VGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARK 328
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
18-330 2.28e-58

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 191.06  E-value: 2.28e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  18 LTVLLAIGLWLSLF--TGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQ 95
Cdd:PRK11228    5 PVAALIGLFWLSLFcySAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  96 VFGVNAGASLVVVLAILFLPSIGSANLIyfAFAGAILGGFT-----VLGFASSRGMTNLKIALVGMAVHLLLTSITKGLI 170
Cdd:PRK11228   85 LLGINSGAALAMALTSALSPTPFAGYSL--AFIAACGGGLSwllvmTAGGGWRHTHDRNRLILAGIALSALCMALTRITL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 171 IYNE-HISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGG 249
Cdd:PRK11228  163 LLAEdHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 250 ASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARKK 329
Cdd:PRK11228  243 ACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRR 322


                  .
gi 2502538158 330 G 330
Cdd:PRK11228  323 G 323
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-325 4.48e-49

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 165.04  E-value: 4.48e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  67 VLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSRGM 146
Cdd:cd06550     2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 147 TNLKIALVGMAVHLLLTSITKGLIIYNEHIS-DVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEV 225
Cdd:cd06550    82 SPSKLILIGIVLSAFFSAGVILISLLSDDSLqDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 226 AMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLIsFP 305
Cdd:cd06550   162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL-LP 240

                         250       260
                  ....*....|....*....|
gi 2502538158 306 FESPVGIVTALLGTPFFLYL 325
Cdd:cd06550   241 SELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 29-330 1.32e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 267.71  E-value: 1.32e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  29 SLFTGVAAIPLQTVLKQ-WSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVV 107
Cdd:COG0609     1 SLSLGAVPISLSDVLRAlLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 108 VLAILFLPSIGSANLIYFAFAGAILGGFTVLGFAS-SRGMTNLKIALVGMAVHLLLTSITKGLIIY--NEHISDVMFWLS 184
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLadPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 185 GSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLM 264
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2502538158 265 IPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARKKG 330
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 21-328 2.11e-78

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 242.05  E-value: 2.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  21 LLAIGLWLSLFTGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVN 100
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 101 AGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSR-GMTNLKIALVGMAVHLLLTSITKGLIIY--NEHIS 177
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRgGASPLRLILAGIAVSALLSALTSLLLLLlnPEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 178 DVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGA 257
Cdd:pfam01032 161 SILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2502538158 258 VGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARK 328
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
18-330 2.28e-58

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 191.06  E-value: 2.28e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  18 LTVLLAIGLWLSLF--TGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQ 95
Cdd:PRK11228    5 PVAALIGLFWLSLFcySAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  96 VFGVNAGASLVVVLAILFLPSIGSANLIyfAFAGAILGGFT-----VLGFASSRGMTNLKIALVGMAVHLLLTSITKGLI 170
Cdd:PRK11228   85 LLGINSGAALAMALTSALSPTPFAGYSL--AFIAACGGGLSwllvmTAGGGWRHTHDRNRLILAGIALSALCMALTRITL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 171 IYNE-HISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGG 249
Cdd:PRK11228  163 LLAEdHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 250 ASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYLARKK 329
Cdd:PRK11228  243 ACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRR 322


                  .
gi 2502538158 330 G 330
Cdd:PRK11228  323 G 323
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 4-325 6.35e-56

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 185.32  E-value: 6.35e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158   4 RRTNKRSLVQTCICLTVLLAIGLWlSLFTGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALM 83
Cdd:COG4779    16 LRLRRRALLVTLVLLLLLLALAVL-ALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  84 QAITRNPFASPQVFGVNAGASLVVVLAILFLPSiGSANLIYFAFAGAILGGFTVLGFASSRGMTNLKIALVGMAVHLLLT 163
Cdd:COG4779    95 QSLTRNPLASPDIIGITAGASAGAVAAIVVLGG-SGLAVALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 164 SITKGLIIYN--EHISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLAC 241
Cdd:COG4779   174 AVNSYLLTRAdlEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 242 AAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDyRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPF 321
Cdd:COG4779   254 LVAVALAAVATAAAGPIAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPY 332


                  ....
gi 2502538158 322 FLYL 325
Cdd:COG4779   333 LLWL 336
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
18-328 6.48e-56

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 192.36  E-value: 6.48e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  18 LTVLLAIGLWLSLFTGVAAIPLQTVLKQ-WSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQV 96
Cdd:PRK10577   17 LALLLLLALALTLTQLSAALPLSQWLQAlWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  97 FGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSRGMTNLKIALVGMAVHLLLTSITKGLIIYNEH- 175
Cdd:PRK10577   97 LGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQy 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 176 ISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVA 255
Cdd:PRK10577  177 LQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAV 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2502538158 256 GAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFES--PVGIVTALLGTPFFLYLARK 328
Cdd:PRK10577  257 GPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGEllPTGAVTALIGAPLLLWLLPR 331
btuC PRK09535
cobalamin ABC transporter permease BtuC;
47-329 1.27e-53

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 179.95  E-value: 1.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  47 SLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVVVLAILFlPSIGSANLIYFA 126
Cdd:PRK09535   80 SFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVL-PLAVPFGLQAAA 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 127 FAGAILGGFTVLGFASSRGMTNLK-IALVGMAVHLLLTSITKGLIIYN-EHISDVMFWLSGSISGATWADVRMILPWSVL 204
Cdd:PRK09535  159 FAGALVAAFGVYAIATENGRTPVAtLLLAGVAVQTFLGAVISYLLLHSgESLRRAVYWLMGHLHGSTWSDVEVALPVVVV 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 205 GLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFAS 284
Cdd:PRK09535  239 GFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTS 318

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2502538158 285 AWGGAVLVTYSDVVARliSFPFESPVGIVTALLGTPFFLYLARKK 329
Cdd:PRK09535  319 ALAGASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRTR 361
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
12-325 3.80e-53

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 177.16  E-value: 3.80e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  12 VQTCICLTVLLAIGLWLSLFTGVAAIPLQTVLKQWSLAepSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPF 91
Cdd:PRK09777    3 IALVIFITLALAGCALLSLRMGVIPLPWRALLTDWQAG--DEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  92 ASPQVFGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGgFTVLGFASSRGMTnLKIALVGMAVHLLLTSITKGLII 171
Cdd:PRK09777   81 ASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAG-LILLKMLAGTHQP-MKLALTGVALSALWASLTDYLML 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 172 YN-EHISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGA 250
Cdd:PRK09777  159 SRpQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTAT 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2502538158 251 SVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFFLYL 325
Cdd:PRK09777  239 GVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWL 313
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
4-331 2.72e-51

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 180.03  E-value: 2.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158   4 RRTNKRSLVQTCICLTVLLAIGLWLSLFTGVAAIPlqtvlkqWSLAEPSKELLIFQTiRLPRAVLGALIGANLAVAGALM 83
Cdd:PRK10577  347 VAARRRRVLAWLLALGLLLLLALVVALSFGRDAHG-------WNWLSGQLLDALLPL-RLPRLLAALLAGAMLAVAGTLL 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  84 QAITRNPFASPQVFGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSRGMTNLKIALVGMAVHLLLT 163
Cdd:PRK10577  419 QRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFT 498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 164 SITKGLIIY-NEHISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACA 242
Cdd:PRK10577  499 ALIQLLLASgDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLL 578

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 243 AIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTPFF 322
Cdd:PRK10577  579 LAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYF 658


                  ....*....
gi 2502538158 323 LYLARKKGR 331
Cdd:PRK10577  659 LWLLRRSRR 667
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-325 4.48e-49

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 165.04  E-value: 4.48e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  67 VLGALIGANLAVAGALMQAITRNPFASPQVFGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTVLGFASSRGM 146
Cdd:cd06550     2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 147 TNLKIALVGMAVHLLLTSITKGLIIYNEHIS-DVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEV 225
Cdd:cd06550    82 SPSKLILIGIVLSAFFSAGVILISLLSDDSLqDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 226 AMGLGQKIVVVRLLACAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLIsFP 305
Cdd:cd06550   162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL-LP 240

                         250       260
                  ....*....|....*....|
gi 2502538158 306 FESPVGIVTALLGTPFFLYL 325
Cdd:cd06550   241 SELPVGPVTALLGAPYFLYL 260
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 1-325 1.96e-48

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 165.41  E-value: 1.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158   1 MTMRRTNKRSLVQTCICLTVLLAIGLWLSLFTGVAAIPLQTVLKqwslaePSKELLIFQtIRLPRAVLGALIGANLAVAG 80
Cdd:COG4139     1 MQLPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLS------EAWQLFVWQ-LRLPRTLAAVLVGASLAVSG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  81 ALMQAITRNPFASPQVFGVNAGASLVVVLAILFLPSIGSANLIYF-AFAGAILGGFTVLGFASsRGMTNLKIALVGMAVH 159
Cdd:COG4139    74 AVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLaAIAGALLVTLLLLAFAR-RRLSNARLLLIGVALG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 160 LLLTSITKGLIIY--NEHISDVMFWLSGSISGATWADVRMILPwSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVR 237
Cdd:COG4139   153 IICSAIMTWAVYFssSLDLRQLMYWMMGSFGGVDWRQLWLLLA-LLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 238 LLACAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALL 317
Cdd:COG4139   232 NLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATL 311


                  ....*...
gi 2502538158 318 GTPFFLYL 325
Cdd:COG4139   312 GAPVFIWL 319
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
17-332 1.83e-47

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 162.95  E-value: 1.83e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  17 CLTVLLAIGLWLSLFTGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGALMQAITRNPFASPQV 96
Cdd:PRK10441   15 GLLLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  97 FGVNAGASLVVVLAILFLPSIGSANLIYFAFAGAILGGFTV--LGFASSRGMTNLKIALVGMAVHLLLTSITKGLIIYNE 174
Cdd:PRK10441   95 LGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVafTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 175 HISDVM-FWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLACAAIVILGGASVA 253
Cdd:PRK10441  175 DVYDQLrFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATA 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2502538158 254 VAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISfPFESPVGIVTALLGTPFFLYLARKKGRE 332
Cdd:PRK10441  255 VVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKTRG 332
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 4-331 7.61e-47

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 161.28  E-value: 7.61e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158   4 RRTNKRSLvqtcICLTVLLAIGLWLSLFTGvaaiplQTVLKQWSLAEPSKELLIFQtIRLPRAVLGALIGANLAVAGALM 83
Cdd:PRK03784   11 QRRNRRWL----LGLSVLLLLALLLSLCAG------EQWISPGDWLSPRGELFVWQ-LRLPRTLAVLLVGAALAVSGAVM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  84 QAITRNPFASPQVFGVNAGASLVVVLAILFLPSIGSANLIYF-AFAGAILGGFTVLGFASSRGMTNLKIALVGMAVHLLL 162
Cdd:PRK03784   80 QALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLcAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIIC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 163 TSITKGLIIYNEHIS--DVMFWLSGSISGATWADVRMILPWsVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVVRLLA 240
Cdd:PRK03784  160 SALMTWAVYFSTSLDlrQLMYWMMGGFGGVDWRQSWLMLAL-LPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 241 CAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDYRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTALLGTP 320
Cdd:PRK03784  239 VLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAP 318

                         330
                  ....*....|.
gi 2502538158 321 FFLYLARKKGR 331
Cdd:PRK03784  319 VFIWLLLRSHR 329
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
3-325 3.35e-32

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 122.51  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158   3 MRRTNKRSLVQTCICLTVLLAIGLWlSLFTGVAAIPLQTVLKQWSLAEPSKELLIFQTIRLPRAVLGALIGANLAVAGAL 82
Cdd:PRK10440    1 MIYVSRRLLITCLLLLAACVAAGLW-GLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158  83 MQAITRNPFASPQVFGVNAGA-SLVVVLAILF---LPSIGSAnliyfAFAGAILGGFTVLGFASSRGMTNLKIALVGMAV 158
Cdd:PRK10440   80 FQSLMRNPLGSPDVMGFNTGAwSGVLVAMVLFgqdLTAIALA-----AMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 159 HLLLTSITKGLIIYN--EHISDVMFWLSGSISGATWADVRMILPWSVLGLALAAGLAGSLSVFRLGEEVAMGLGQKIVVV 236
Cdd:PRK10440  155 RAMLVAFNTWLLLKAslETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502538158 237 RLLACAAIVILGGASVAVAGAVGFIGLMIPHIARKLVGTDyRAVIFASAWGGAVLVTYSDVVARLISFPFESPVGIVTAL 316
Cdd:PRK10440  235 RLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVS 313


                  ....*....
gi 2502538158 317 LGTPFFLYL 325
Cdd:PRK10440  314 LGGIYLIVL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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