NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2504949786|ref|WP_282405603|]
View 

AraC family transcriptional regulator [Pseudomonas shahriarae]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117701)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain and an N-terminal arabinose binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 27-212 2.55e-40

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 140.09  E-value: 2.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  27 GLDPQPLLLQYGLDPARLNEPGARLSIPRYMRLGHAAIQQTGDPSLGLRMGQLSRMNQLGLAGVTAAQAPNVREAARTLT 106
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 107 RFEALYGaNYRGQSSFHEDAQGAWLRFYSISPYNAYNRFVVDSILAGWLQQMATLCQQPVLAERIEIEFAAPDYSASYTV 186
Cdd:pfam12625  81 RYLRLLS-DALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2504949786 187 LGDCPIQFGAELNQLRLSQHSLGLRN 212
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 6.98e-19

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 79.90  E-value: 6.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  257 EPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2504949786  336 GEFR 339
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 27-212 2.55e-40

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 140.09  E-value: 2.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  27 GLDPQPLLLQYGLDPARLNEPGARLSIPRYMRLGHAAIQQTGDPSLGLRMGQLSRMNQLGLAGVTAAQAPNVREAARTLT 106
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 107 RFEALYGaNYRGQSSFHEDAQGAWLRFYSISPYNAYNRFVVDSILAGWLQQMATLCQQPVLAERIEIEFAAPDYSASYTV 186
Cdd:pfam12625  81 RYLRLLS-DALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2504949786 187 LGDCPIQFGAELNQLRLSQHSLGLRN 212
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 6.98e-19

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 79.90  E-value: 6.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  257 EPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2504949786  336 GEFR 339
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
99-346 2.44e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 80.59  E-value: 2.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  99 REAARTLTRFEALYGANYRGQSSFHEDAQGAWLRFYSISPYNAYNRFVVDSILAGWLQQMATLCQQPVLAERIEIEFAAP 178
Cdd:COG2207    15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 179 DYSASYTVLGDCPIQFGAELNQLRLSQHSLGLRNPQHCPSTWHLLLQLCERELEQLTRTRSLRERITRLLGPMLNggrep 258
Cdd:COG2207    95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL----- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 259 DLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGE 337
Cdd:COG2207   170 TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                  ....*....
gi 2504949786 338 FRRSQRHSA 346
Cdd:COG2207   250 YRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
263-341 2.97e-12

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 61.45  E-value: 2.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 263 VAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTY-IRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRR 340
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLlLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2504949786 341 S 341
Cdd:pfam12833  81 R 81
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 239-344 3.21e-10

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 60.39  E-value: 3.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 239 SLRERITRLLGPmlNGGREPDLEEVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFA 318
Cdd:PRK15185  206 TLKERVYNIISS--SPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYD 283

                          90       100
                  ....*....|....*....|....*.
gi 2504949786 319 SAEAFQRAFKRWNSQTPGEFRRSQRH 344
Cdd:PRK15185  284 STSYFIQCFKKYFKTTPSTFIKMANH 309
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 232-346 7.37e-07

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 50.16  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 232 EQLTRTRSLRERITRLLGPML-NGGREPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFG 309
Cdd:COG4977   200 PLLVPLGHRDPRLARAQAWMEaNLEEPLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIE 279

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2504949786 310 EIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 346
Cdd:COG4977   280 EIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 27-212 2.55e-40

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 140.09  E-value: 2.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  27 GLDPQPLLLQYGLDPARLNEPGARLSIPRYMRLGHAAIQQTGDPSLGLRMGQLSRMNQLGLAGVTAAQAPNVREAARTLT 106
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 107 RFEALYGaNYRGQSSFHEDAQGAWLRFYSISPYNAYNRFVVDSILAGWLQQMATLCQQPVLAERIEIEFAAPDYSASYTV 186
Cdd:pfam12625  81 RYLRLLS-DALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 2504949786 187 LGDCPIQFGAELNQLRLSQHSLGLRN 212
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 6.98e-19

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 79.90  E-value: 6.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  257 EPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2504949786  336 GEFR 339
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
99-346 2.44e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 80.59  E-value: 2.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786  99 REAARTLTRFEALYGANYRGQSSFHEDAQGAWLRFYSISPYNAYNRFVVDSILAGWLQQMATLCQQPVLAERIEIEFAAP 178
Cdd:COG2207    15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 179 DYSASYTVLGDCPIQFGAELNQLRLSQHSLGLRNPQHCPSTWHLLLQLCERELEQLTRTRSLRERITRLLGPMLNggrep 258
Cdd:COG2207    95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL----- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 259 DLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGE 337
Cdd:COG2207   170 TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                  ....*....
gi 2504949786 338 FRRSQRHSA 346
Cdd:COG2207   250 YRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
263-341 2.97e-12

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 61.45  E-value: 2.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 263 VAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTY-IRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRR 340
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLlLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 2504949786 341 S 341
Cdd:pfam12833  81 R 81
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 239-344 3.21e-10

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 60.39  E-value: 3.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 239 SLRERITRLLGPmlNGGREPDLEEVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFA 318
Cdd:PRK15185  206 TLKERVYNIISS--SPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYD 283

                          90       100
                  ....*....|....*....|....*.
gi 2504949786 319 SAEAFQRAFKRWNSQTPGEFRRSQRH 344
Cdd:PRK15185  284 STSYFIQCFKKYFKTTPSTFIKMANH 309
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 229-338 1.43e-08

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 55.07  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 229 RELEQltrtRSLRERITRLLgpMLNGGREPDLEEVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAF 308
Cdd:PRK15186  175 RELSQ----NTLAENIYNII--ISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNI 248

                          90       100       110
                  ....*....|....*....|....*....|
gi 2504949786 309 GEIAYLLGFASAEAFQRAFKRWNSQTPGEF 338
Cdd:PRK15186  249 TRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 232-346 7.37e-07

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 50.16  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 232 EQLTRTRSLRERITRLLGPML-NGGREPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFG 309
Cdd:COG4977   200 PLLVPLGHRDPRLARAQAWMEaNLEEPLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIE 279

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2504949786 310 EIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 346
Cdd:COG4977   280 EIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
259-341 1.07e-05

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 43.76  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 259 DLEEVAARLKLPTWTLRRklaeegtQFRAILNDT--------RRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRW 330
Cdd:PRK10219   23 NIDVVAKKSGYSKWYLQR-------MFRTVTHQTlgdyirqrRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQ 95

                          90
                  ....*....|.
gi 2504949786 331 NSQTPGEFRRS 341
Cdd:PRK10219   96 FDRTPSDYRHR 106
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 262-344 2.07e-05

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 45.79  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 262 EVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRS 341
Cdd:PRK15044  213 EVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSFMRT 292


                  ...
gi 2504949786 342 QRH 344
Cdd:PRK15044  293 MNH 295
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 253-344 4.82e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.53  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 253 NGGREPDLEEVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNS 332
Cdd:PRK09978  154 NIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYG 233

                          90
                  ....*....|...
gi 2504949786 333 QTPGEFR-RSQRH 344
Cdd:PRK09978  234 MTPTEYQeRSAQG 246
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 256-343 6.67e-05

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 44.27  E-value: 6.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 256 REPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIrDTELAFGEIAYLLGFASAEAFQRAFKRWNSQT 334
Cdd:COG2169    99 DRPSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMT 177


                  ....*....
gi 2504949786 335 PGEFRRSQR 343
Cdd:COG2169   178 PSAYRRGGA 186
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 222-343 2.31e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 42.33  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 222 LLLQLCERELEQLTRTRSLRERITRLLGPML------NGGR----------------EPDL--EEVAARLKLPTWTLRRK 277
Cdd:PRK09685  155 LLQQSMNGPALSETESEALLEALIALLRPALhqresvQPRRerqfqkvvalidqsiqEEILrpEWIAGELGISVRSLYRL 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2504949786 278 LAEEGTQF-RAILNdTRRDLAMTYIR----DTELAfgEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQR 343
Cdd:PRK09685  235 FAEQGLVVaQYIRN-RRLDRCADDLRpaadDEKIT--SIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 303-340 2.50e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.21  E-value: 2.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2504949786 303 DTELAFGEIAYLLGFaSAEAFQRAFKRWNSQTPGEFRR 340
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 288-341 2.81e-03

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 38.97  E-value: 2.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2504949786 288 ILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRS 341
Cdd:PRK10296  220 IINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
242-339 3.37e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 38.89  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 242 ERITRLLGPMLNG-GREPDLEEVAARLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFAS 319
Cdd:PRK13503  171 ARLNQLLAWLEDHfAEEVNWEALADQFSLSLRTLHRQLKQQtGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGD 250

                          90       100
                  ....*....|....*....|
gi 2504949786 320 AEAFQRAFKRWNSQTPGEFR 339
Cdd:PRK13503  251 SNHFSTLFRREFSWSPRDIR 270
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 260-343 4.74e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 38.14  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504949786 260 LEEVAARLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRdTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFR 339
Cdd:PRK09940  153 LKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIR-VEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVS 231


                  ....
gi 2504949786 340 RSQR 343
Cdd:PRK09940  232 KEYR 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH