|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
526-760 |
6.07e-63 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 210.53 E-value: 6.07e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 526 ELIQARRLAERAE-LKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSETEKREYAGIIDTNTKLLLKLVDDVLQLSRME 604
Cdd:COG2205 1 ELEEALEELEELErLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 605 TANMSFDLRRESVRHLL-EAVYRTHSVLIKPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEG-HIRLGYVR 682
Cdd:COG2205 81 SGKLSLELEPVDLAELLeEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 683 LPatREVSIYVEDTGIGIPQEEREMIFARFY--KRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG2205 161 EG--DGVRISVSDNGPGIPEEELERIFERFYrgDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
501-760 |
1.79e-58 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 203.63 E-value: 1.79e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 501 ATVSGGKYIITGLLQNIQDVKDHEEELIQARRLAERaeLKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSETEKREYA 580
Cdd:COG5002 128 LLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQ--MRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 581 GIIDTNTKLLLKLVDDVLQLSRMETANMSFDLRRESVRHLLEAVYRTHSVLIKP-PLEFIADFPAEDAFVHADRMRLTQV 659
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEkGIELELDLPEDPLLVLGDPDRLEQV 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 660 VTNFLNNAGKFTSEGhirlGYVRLPATRE---VSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVI 732
Cdd:COG5002 286 LTNLLDNAIKYTPEG----GTITVSLREEddqVRISVRDTGIGIPEEDLPRIFERFYRvdksRSRETGGTGLGLAIVKHI 361
|
250 260
....*....|....*....|....*...
gi 2507778881 733 VERLGGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG5002 362 VEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
435-759 |
4.66e-58 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 200.52 E-value: 4.66e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 435 FYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRASENVHTHKGQYRFDFTGGGYEWWELRYSTLPATVSGGKYIITGLL 514
Cdd:COG0642 5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 515 QNIQDVKDHEEELIQARRLAERAELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPElseTEKREYAGIIDTNTKLLLKLV 594
Cdd:COG0642 85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD---EEQREYLETILRSADRLLRLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 595 DDVLQLSRMETANMSFDLRRESVRHLLEAVYRTHSVLI-KPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSE 673
Cdd:COG0642 162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAeEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 674 GhirlGYVRLPATRE---VSIYVEDTGIGIPQEEREMIFARFY--KRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGR 748
Cdd:COG0642 242 G----GTVTVSVRREgdrVRISVEDTGPGIPPEDLERIFEPFFrtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
330
....*....|.
gi 2507778881 749 GSRFTVVLPCA 759
Cdd:COG0642 318 GTTFTVTLPLA 328
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
336-757 |
8.15e-43 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 162.65 E-value: 8.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 336 HVLQRYGIPLSRIPKEYTVMYIPFTERYHYTLLYIAVLSGLLLLLFIAFLIRSLSVERRRKREAQHSLRYEHETLTLAIS 415
Cdd:COG4251 72 LLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 416 GSSTYVWRLEGEGIICDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRASENVHTHKGQYRFDFTGGGYEWWELR 495
Cdd:COG4251 152 LLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 496 YSTLPATVSGGKYIITGLLQNIQD-----VKDHEEELIQARRLAERA--ELKQsFLNNMSHEIRTPLNAIAGFANLLV-- 566
Cdd:COG4251 232 LLLLVLLLLLILLLLLLILVLELLelrleLEELEEELEERTAELERSneELEQ-FAYVASHDLREPLRKISGFSQLLEed 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 567 YDPELSEtEKREYAGIIDTNTKLLLKLVDDVLQLSRMETANMSF---DLRR--ESVRHLLEAVYRTHSVLIKpplefIAD 641
Cdd:COG4251 311 YGDKLDE-EGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFepvDLNEllEEVLEDLEPRIEERGAEIE-----VGP 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 642 FPAedafVHADRMRLTQVVTNFLNNAGKFTSEG---HIRLGYVRLPatREVSIYVEDTGIGIPQEEREMIFARFYK---R 715
Cdd:COG4251 385 LPT----VRGDPTLLRQVFQNLISNAIKYSRPGeppRIEIGAEREG--GEWVFSVRDNGIGIDPEYAEKIFEIFQRlhsR 458
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2507778881 716 SEFSqGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:COG4251 459 DEYE-GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
395-759 |
2.63e-39 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 149.18 E-value: 2.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 395 RKREAQHSLRYEHETLTLAISGSSTYVWRLEGEGIICDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRASENVH 474
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 475 THKGQYRFDFTGGGYEWWELRYSTLPATVSGGKYIITGLLQNIQDVKDHEEELIQARRLAERAELkqsfLNNMSHEIRTP 554
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGEL----AAGIAHEINNP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 555 LNAIAGFANLLV--YDPELSETEKREYAGIIDTNTKLLLKLVDDVLQLSRMETANM-SFDLRR--ESVRHLLEAVYRTHS 629
Cdd:COG4191 157 LAAILGNAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEERePVDLNEliDEALELLRPRLKARG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 630 VlikpplEFIADFPAEDAFVHADRMRLTQVVTNFLNNA-----GKftSEGHIRlgyVRL-PATREVSIYVEDTGIGIPQE 703
Cdd:COG4191 237 I------EVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameEG--EGGRIT---ISTrREGDYVVISVRDNGPGIPPE 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2507778881 704 EREMIFARFY--KRSefSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLPCA 759
Cdd:COG4191 306 VLERIFEPFFttKPV--GKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
402-760 |
3.53e-38 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 145.76 E-value: 3.53e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 402 SLRYEHETLTLAISGSSTYVWRLEGEGIICD--PHFYDLIRHPRERI---TLDEIIHFLHPDdRERFYRSYRASENVHTH 476
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYvnPAAERLLGLSAEELlgrPLAELFPEDSPL-RELLERALAEGQPVTER 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 477 KGQYRfdfTGGGYEWWeLRYSTLPATVSGGKYIITGLLQNIQDVKDHEEELIQARRLAERAELkqsfLNNMSHEIRTPLN 556
Cdd:COG3852 80 EVTLR---RKDGEERP-VDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRRAEKLAAVGEL----AAGLAHEIRNPLT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 557 AIAGFANLLvyDPELSETEKREYAGIIDTNTKlllklvddvlQL----SRMETANMSFDLRRESV--RHLLEAVYRTHSV 630
Cdd:COG3852 152 GIRGAAQLL--ERELPDDELREYTQLIIEEAD----------RLnnlvDRLLSFSRPRPPEREPVnlHEVLERVLELLRA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 631 LIKPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEG---HIRLGYVR------LPATREVSIYVEDTGIGIP 701
Cdd:COG3852 220 EAPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGgtiTIRTRVERqvtlggLRPRLYVRIEVIDNGPGIP 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2507778881 702 QEEREMIFARFykrseFS---QGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG3852 300 EEILDRIFEPF-----FTtkeKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
518-760 |
4.33e-38 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 153.01 E-value: 4.33e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 518 QDVKDHEeeliQARRLAERA-ELKQSFLNNMSHEIRTPLNAIAGFANLLVyDPELSeTEKREYAGIIDTNTKLLLKLVDD 596
Cdd:TIGR02956 445 AEVKNHA----KARAEAEEAnRAKSAFLATMSHEIRTPLNGILGTLELLG-DTGLT-SQQQQYLQVINRSGESLLDILND 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 597 VLQLSRMETANMS-----FDLRR--ESVRHLLEAvyRTHSVLIKPPLEFIADFPaedAFVHADRMRLTQVVTNFLNNAGK 669
Cdd:TIGR02956 519 ILDYSKIEAGHLSisprpFDLNAllDDVHHLMVS--RAQLKGIQLRLNIPEQLP---NWWQGDGPRIRQVLINLVGNAIK 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 670 FTSEGHIRLGyVRLPATREVSIYVEDTGIGIPQEEREMIFARFYKRS--EFSQGVGLGLPICKVIVERLGGRIEVKSQVG 747
Cdd:TIGR02956 594 FTDRGSVVLR-VSLNDDSSLLFEVEDTGCGIAEEEQATLFDAFTQADgrRRSGGTGLGLAISQRLVEAMDGELGVESELG 672
|
250
....*....|...
gi 2507778881 748 RGSRFTVVLPCAE 760
Cdd:TIGR02956 673 VGSCFWFTLPLTR 685
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
394-760 |
1.39e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 145.88 E-value: 1.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 394 RRKREAQHSLRYEHETLtlaISGSSTYVWRLEGEGII--CDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRASE 471
Cdd:COG5000 79 KEQREELEERRRYLETI---LENLPAGVIVLDADGRItlANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERG 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 472 nvhthkGQYRFDFTGGGYEWWELRYSTLPatvsGGKYIITgllqnIQDVkdheEELIQARRLAERAELKQSflnnMSHEI 551
Cdd:COG5000 156 ------WQEEIELTRDGRRTLLVRASPLR----DDGYVIV-----FDDI----TELLRAERLAAWGELARR----IAHEI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 552 RTPLNAIAGFANLL--VYDPELSETEK--REYAGIIDTNTKLLLKLVDDVLQLSRMETANMS-FDLRR--ESVRHLLEAV 624
Cdd:COG5000 213 KNPLTPIQLSAERLrrKLADKLEEDREdlERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEpVDLNEllREVLALYEPA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 625 YRTHSVlikpplEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSE-GHIRlgyVRL-PATREVSIYVEDTGIGIPQ 702
Cdd:COG5000 293 LKEKDI------RLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEgGEIE---VSTrREDGRVRIEVSDNGPGIPE 363
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2507778881 703 EEREMIFARFYkrSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG5000 364 EVLERIFEPFF--TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
391-757 |
5.34e-35 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 139.72 E-value: 5.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 391 VERRRKREAQhsLRYEHETLTLAISGSSTYVWRLEGEGIICD--PHFYDLIRHPRERITLDEIIHFLHPDDRERF----- 463
Cdd:COG5809 126 ITERKRMEEA--LRESEEKFRLIFNHSPDGIIVTDLDGRIIYanPAACKLLGISIEELIGKSILELIHSDDQENVaafis 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 464 ----YRSYRASENVHTHK-GQYRfdftgggyewwELRYSTLPATVSGGKYIITGLLQNIQDVKDHEEELIQARRLAERAE 538
Cdd:COG5809 204 qllkDGGIAQGEVRFWTKdGRWR-----------LLEASGAPIKKNGEVDGIVIIFRDITERKKLEELLRKSEKLSVVGE 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 539 LKQSflnnMSHEIRTPLNAIAGFANLLVYDpelSETEKREYAGIIDTntklllklvddvlQLSRME-------------T 605
Cdd:COG5809 273 LAAG----IAHEIRNPLTSLKGFIQLLKDT---IDEEQKTYLDIMLS-------------ELDRIEsiiseflvlakpqA 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 606 ANM-SFDLRR--ESVRHLLEAVYRTHSVLIKppLEFIADFPaedaFVHADRMRLTQVVTNFLNNAGKFTSEGhirlGYVR 682
Cdd:COG5809 333 IKYePKDLNTliEEVIPLLQPQALLKNVQIE--LELEDDIP----DILGDENQLKQVFINLLKNAIEAMPEG----GNIT 402
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507778881 683 LPATRE----VSIYVEDTGIGIPQEEREMIFARFYKRSEfsQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:COG5809 403 IETKAEdddkVVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
340-757 |
4.50e-33 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 134.09 E-value: 4.50e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 340 RYGIPLSRIPKEYTVMYIPFTERYHYTLLYI-AVLSGLLLLLFIAFLIRSLSVERRRKREAQhsLRYEHETLTLAISGSS 418
Cdd:COG5805 90 RVKTRIERLQKGYDVVMIEQIYCKDGELIYVeVKLFPIYNQNGQAAILALRDITKKKKIEEI--LQEQEERLQTLIENSP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 419 TYVWRLEGEGIICD--PHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRASENVHTHKGQYRFDFTGGGYEWW-ELR 495
Cdd:COG5805 168 DLICVIDTDGRILFinESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREIITKDGRIRYfEAV 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 496 YSTLPATVSGGKYIItGLLQNIQDVKDHEEELIQARRLAERAELKQSFlnnmSHEIRTPLNAIAGFANLLvydpELSETE 575
Cdd:COG5805 248 IVPLIDTDGSVKGIL-VILRDITEKKEAEELMARSEKLSIAGQLAAGI----AHEIRNPLTSIKGFLQLL----QPGIED 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 576 KREYAGIIdtntklllklvddVLQLSRMET---------ANMSFDLRRESVRHLLEAVY-------RTHSVLIkpplefI 639
Cdd:COG5805 319 KEEYFDIM-------------LSELDRIESiiseflalaKPQAVNKEKENINELIQDVVtlleteaILHNIQI------R 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 640 ADFPAEDAFVHADRMRLTQVVTNFLNNA-------GKFTSegHIRLGYvrlpatREVSIYVEDTGIGIPQEEREMIFARF 712
Cdd:COG5805 380 LELLDEDPFIYCDENQIKQVFINLIKNAieampngGTITI--HTEEED------NSVIIRVIDEGIGIPEERLKKLGEPF 451
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2507778881 713 YKRSEfsQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:COG5805 452 FTTKE--KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
482-757 |
1.25e-31 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 131.99 E-value: 1.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 482 FDFTGGGYEWWELRysTLPATVSGGKYIitGLL---QNIQDVKDHEEELIQARRLaeraelKQSFLNNMSHEIRTPLNAI 558
Cdd:PRK11091 232 LDYPDGRKACFELR--KVPFYDRVGKRH--GLMgfgRDITERKRYQDALEKASRD------KTTFISTISHELRTPLNGI 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 559 AGFANLLVyDPELSEtEKREYAG---------------IIDtntklllklvddvlqLSRMETANMSFDLRRESVRHLLEA 623
Cdd:PRK11091 302 VGLSRILL-DTELTA-EQRKYLKtihvsaitlgnifndIID---------------MDKMERRKLQLDNQPIDFTDFLAD 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 624 VyRTHSVLIKPP--LEFIADfPAED--AFVHADRMRLTQVVTNFLNNAGKFTSEGHIRLGYVRLPATReVSIYVEDTGIG 699
Cdd:PRK11091 365 L-ENLSGLQAEQkgLRFDLE-PLLPlpHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDM-LTFEVEDSGIG 441
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2507778881 700 IPQEEREMIFARFY-----KRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK11091 442 IPEDELDKIFAMYYqvkdsHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
656-758 |
1.32e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 118.75 E-value: 1.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGHIRLgYVRLPATRE----VSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLP 727
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTL-RVSLEEEEEdgvqLRFSVEDTGIGIPEEQQARLFEPFSQadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 2507778881 728 ICKVIVERLGGRIEVKSQVGRGSRFTVVLPC 758
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
522-756 |
3.91e-31 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 124.63 E-value: 3.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 522 DHEEELIQAR---RLAERAELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSETEKREYAGIIDTNTKLLLKLVDDVL 598
Cdd:TIGR02966 93 GEEQKLLVARdvtRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 599 QLSRMETANMSFDLRRESVRHLLEAVYRTHSVLI---KPPLEFIADfpaEDAFVHADRMRLTQVVTNFLNNAGKFTSEG- 674
Cdd:TIGR02966 173 TLSRLESAASPLEDEPVDMPALLDHLRDEAEALSqgkNHQITFEID---GGVDVLGDEDELRSAFSNLVSNAIKYTPEGg 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 675 HIRLGYVRLPATREVSiyVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGS 750
Cdd:TIGR02966 250 TITVRWRRDGGGAEFS--VTDTGIGIAPEHLPRLTERFYRvdksRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGS 327
|
....*.
gi 2507778881 751 RFTVVL 756
Cdd:TIGR02966 328 TFSFIF 333
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
520-757 |
5.88e-31 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 130.53 E-value: 5.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 520 VKDHEEELIQARRLAERA-ELKQSFLNNMSHEIRTPLNAIAGFANLLvYDPELSEtekrEYAGIIDTNTKLLLKLVDDVL 598
Cdd:PRK15347 377 VAERTQALAEAKQRAEQAnKRKSEHLTTISHEIRTPLNGVLGALELL-QNTPLTA----EQMDLADTARQCTLSLLAIIN 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 599 QL---SRMETANMSFDLRRESVRHLLEAVYRT-HSVLIKPPLE---FI-ADFPAEdafVHADRMRLTQVVTNFLNNAGKF 670
Cdd:PRK15347 452 NLldfSRIESGQMTLSLEETALLPLLDQAMLTiQGPAQSKSLTlrtFVgAHVPLY---LHLDSLRLRQILVNLLGNAVKF 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 671 TSEGHIRLgYVRLPATReVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGS 750
Cdd:PRK15347 529 TETGGIRL-RVKRHEQQ-LCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGS 606
|
....*..
gi 2507778881 751 RFTVVLP 757
Cdd:PRK15347 607 CFSLVLP 613
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
529-757 |
7.45e-31 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 130.03 E-value: 7.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 529 QARRLAERA-ELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSETekREYAGIIDTNTKLLLKLVDDVLQLSRMETAN 607
Cdd:PRK11466 432 QARAEAEKAsQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQ--RDDLRAITDSGESLLTILNDILDYSAIEAGG 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 608 MSFDLRRE--SVRHLLEAVYR-THSVLIKPPLEFIADFpAED--AFVHADRMRLTQVVTNFLNNAGKFTSEGHIRLGyvr 682
Cdd:PRK11466 510 KNVSVSDEpfEPRPLLESTLQlMSGRVKGRPIRLATDI-ADDlpTALMGDPRRIRQVITNLLSNALRFTDEGSIVLR--- 585
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2507778881 683 lPATREVS--IYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK11466 586 -SRTDGEQwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
651-757 |
1.04e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.21 E-value: 1.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 651 ADRMRLTQVVTNFLNNAGKFTSE-GHIRlgyVRL-PATREVSIYVEDTGIGIPQEEREMIFARFYK---RSEFSQGVGLG 725
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEgGRIT---VTLeRDGDHVEITVEDNGPGIPPEDLEKIFEPFFRtdkRSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|..
gi 2507778881 726 LPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
510-758 |
1.33e-29 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 124.48 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 510 ITGLLQNIQDVKDHEEeLIQARRlaeraelkqSFLNNMSHEIRTPLNAIAGFANLL----VYDPEL---------SETEk 576
Cdd:NF033092 352 INGLIAVLHDVTEQEK-IEQERR---------EFVANVSHELRTPLTTMRSYLEALadgaWKDPELaprflgvtqNETE- 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 577 REYAGIIDtntklllklvddVLQLSRMETANMSFDLRRESVRHLLEAVYRTHSVLIKP-PLEFIADFPAEDAFVHADRMR 655
Cdd:NF033092 421 RMIRLVND------------LLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNkNITFKREFPKRDLWVEIDTDK 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSE-GHIRlgyVRLPATR-EVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPIC 729
Cdd:NF033092 489 ITQVLDNIISNAIKYSPEgGTIT---FRLLETHnRIIISISDQGLGIPKKDLDKIFDRFYRvdkaRSRKMGGTGLGLAIA 565
|
250 260
....*....|....*....|....*....
gi 2507778881 730 KVIVERLGGRIEVKSQVGRGSRFTVVLPC 758
Cdd:NF033092 566 KEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
517-758 |
9.67e-29 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 123.42 E-value: 9.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 517 IQDVkdheeELIQARRLA-ERAELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPeLSETEkREYAGIID---TNTklllk 592
Cdd:PRK11107 274 IQNV-----ELDLAKKRAqEAARIKSEFLANMSHELRTPLNGVIGFTRQTLKTP-LTPTQ-RDYLQTIErsaNNL----- 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 593 lvddvlqLS--------------RMETANMSFDLRR--ESVRHLLeavyrTHSVLIKpPLEFIADFPAE--DAFVhADRM 654
Cdd:PRK11107 342 -------LAiindildfskleagKLVLENIPFSLREtlDEVVTLL-----AHSAHEK-GLELTLNIDPDvpDNVI-GDPL 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 655 RLTQVVTNFLNNAGKFTSEGHIRLgYVRLPATRE--VSIYVE--DTGIGIPQEEREMIFarfykrSEFSQ---------- 720
Cdd:PRK11107 408 RLQQIITNLVGNAIKFTESGNIDI-LVELRALSNtkVQLEVQirDTGIGISERQQSQLF------QAFRQadasisrrhg 480
|
250 260 270
....*....|....*....|....*....|....*...
gi 2507778881 721 GVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLPC 758
Cdd:PRK11107 481 GTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
651-757 |
1.58e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 110.15 E-value: 1.58e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 651 ADRMRLTQVVTNFLNNAGKFTSE-GHIRlgyVRLPATREVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQ-GVGLGLPI 728
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKaGEIT---VTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 2507778881 729 CKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
656-756 |
1.96e-27 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 106.53 E-value: 1.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSE-GHIRLGYVRLPatREVSIYVEDTGIGIPQEEREMIFARFY--KRSEFSQGVGLGLPICKVI 732
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPgGTIEISLRQEG--DGVVLEVEDNGPGIPEEDLERIFERFYrgDKSREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 2507778881 733 VERLGGRIEVKSQVGRGSRFTVVL 756
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
524-757 |
4.84e-26 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 110.81 E-value: 4.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 524 EEELIQARR----LAERAELKQSFLNNMSHEIRTPLNAiagfANLLVydpelsETEKREYagiIDTNTKLLLKLVD---- 595
Cdd:PRK09303 131 SDELFVLRQenetLLEQLKFKDRVLAMLAHDLRTPLTA----ASLAL------ETLELGQ---IDEDTELKPALIEqlqd 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 596 -DVLQLSRMETanMSFDLRrESVRHL-----------------LEAVYRTHSVLIKPPLEFIADFPAEDAFVHADRMRLT 657
Cdd:PRK09303 198 qARRQLEEIER--LITDLL-EVGRTRwealrfnpqkldlgslcQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIR 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 658 QVVTNFLNNAGKFTSEGhirlGYVRLPA----TREVSIYVEDTGIGIPQEEREMIFA-RF-YKRSEFSQGVGLGLPICKV 731
Cdd:PRK09303 275 QVLLNLLDNAIKYTPEG----GTITLSMlhrtTQKVQVSICDTGPGIPEEEQERIFEdRVrLPRDEGTEGYGIGLSVCRR 350
|
250 260
....*....|....*....|....*.
gi 2507778881 732 IVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK09303 351 IVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
524-757 |
1.62e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 105.82 E-value: 1.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 524 EEELIQARRLAERAELKQSflnnMSHEIRTPLNAIAGFANLLVYDPELSETekREYAGIIDTNTKLLLKLVDDVLQLSRM 603
Cdd:PRK11360 378 QRRVARQERLAALGELVAG----VAHEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSRP 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 604 ETANMS----FDLRRESVRHLLEAvyrTHSVLIKPPLEFIADFPAedafVHADRMRLTQVVTNFLNNAGK-FTSEGHIRL 678
Cdd:PRK11360 452 RESQWQpvslNALVEEVLQLFQTA---GVQARVDFETELDNELPP----IWADPELLKQVLLNILINAVQaISARGKIRI 524
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507778881 679 GyVRLPATREVSIYVEDTGIGIPQEEREMIFARFYkrSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK11360 525 R-TWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFF--TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
653-757 |
1.49e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 92.87 E-value: 1.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 653 RMRLTQVVTNFLNNAGKFTSE-GHIRlgyVRLPAT-REVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICK 730
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGrGRIT---IRTWAHvDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 2507778881 731 VIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
529-757 |
2.23e-22 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 102.81 E-value: 2.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 529 QARRLAERAELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSETEKREYAGIIDTNTKLLLKLVDDVLQLSRMETAnm 608
Cdd:PRK10490 653 QARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSG-- 730
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 609 SFDLRRE---------SVRHLLEAVYRTHSVLIkpplefiaDFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEgHIRLG 679
Cdd:PRK10490 731 GFNLRKEwltleevvgSALQMLEPGLSGHPINL--------SLPEPLTLIHVDGPLFERVLINLLENAVKYAGA-QAEIG 801
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 680 yvrLPATRE---VSIYVEDTGIGIPQEEREMIFARFYKRSEFSQ--GVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTV 754
Cdd:PRK10490 802 ---IDAHVEgerLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
...
gi 2507778881 755 VLP 757
Cdd:PRK10490 879 TLP 881
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
541-757 |
3.11e-21 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 97.46 E-value: 3.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 541 QSFLNNMSHEIRTPLNAIAGFANLLVYDPELSEtekrEYAGIIDTNtklllklVDDVLQLSRMeTANMSFDLRRESVRHL 620
Cdd:TIGR01386 242 SQFSADLAHELRTPLTNLLGQTQVALSQPRTGE----EYREVLESN-------LEELERLSRM-VSDMLFLARADNGQLA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 621 LEavyrTHSVLIKPPLEFIADF---PAED----------AFVHADRMRLTQVVTNFLNNAGKFTSEGH-IRLGYVRlpAT 686
Cdd:TIGR01386 310 LE----RVRLDLAAELAKVAEYfepLAEErgvrirvegeGLVRGDPQMFRRAISNLLSNALRHTPDGGtITVRIER--RS 383
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507778881 687 REVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRgSRFTVVLP 757
Cdd:TIGR01386 384 DEVRVSVSNPGPGIPPEHLSRLFDRFYRvdpaRSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
3.70e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 88.92 E-value: 3.70e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEG---HIRLGYVRLPatREVSIYVEDTGIGIPQEEREMIFARFYK---RSEFsQGVGLGLPIC 729
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrppRIEVGAEDVG--EEWTFYVRDNGIGIDPEYAEKVFGIFQRlhsREEY-EGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 2507778881 730 KVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
515-757 |
2.06e-20 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 97.11 E-value: 2.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 515 QNIQDVKDHEEELIQARRLAERAELKQS-FLNNMSHEIRTPLNAIAGFANLLVyDPELSETEKREYAGIIDTNTKLLLKL 593
Cdd:PRK09959 686 QDITETRDLIHALEVERNKAINATVAKSqFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGL 764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 594 VDDVLQLSRMETANMSFDLRRESVRHLLEAVYRTHSVLIKP---PLEFIADFPaEDAFVHADRMRLTQVVTNFLNNAGKF 670
Cdd:PRK09959 765 IGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASksiALSCSSTFP-DHYLVKIDPQAFKQVLSNLLSNALKF 843
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 671 TSEGHIRL--GYVRLPATREV-SIYVEDTGIGIPQEEREMIFARFYKRSEFSQ--GVGLGLPICKVIVERLGGRIEVKSQ 745
Cdd:PRK09959 844 TTEGAVKIttSLGHIDDNHAViKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMICKELIKNMQGDLSLESH 923
|
250
....*....|..
gi 2507778881 746 VGRGSRFTVVLP 757
Cdd:PRK09959 924 PGIGTTFTITIP 935
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
524-757 |
8.69e-20 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 94.66 E-value: 8.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 524 EEELIQARRLAERA-ELKQSFLNNMSHEIRTPLNAIAGfaNL-LVYDPELSETEKREYAG--------------IIDtnt 587
Cdd:PRK10841 430 EESLQEMAQAAEQAsQSKSMFLATVSHELRTPLYGIIG--NLdLLQTKELPKGVDRLVTAmnnssslllkiisdILD--- 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 588 klllklvddvlqLSRMETANMSFDLR----RESVRHLLeAVYRthSVLIKPPLE---FI-ADFPAedaFVHADRMRLTQV 659
Cdd:PRK10841 505 ------------FSKIESEQLKIEPRefspREVINHIT-ANYL--PLVVKKRLGlycFIePDVPV---ALNGDPMRLQQV 566
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 660 VTNFLNNAGKFTSEGHIRL------GYVrlpatrevSIYVEDTGIGIPQEEREMIFARFYKRSE----FSQGVGLGLPIC 729
Cdd:PRK10841 567 ISNLLSNAIKFTDTGCIVLhvrvdgDYL--------SFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrNFQGTGLGLAIC 638
|
250 260
....*....|....*....|....*...
gi 2507778881 730 KVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK10841 639 EKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
644-754 |
2.12e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 84.38 E-value: 2.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 644 AEDAFVHADRMRLTQVVTNFLNNAGKFTSEGHIRLgyVRLPATREVSIYVEDTGIGIPQEEREMIFARFYKR-SEFSQGV 722
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVE--IKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSdGQNYGGS 79
|
90 100 110
....*....|....*....|....*....|..
gi 2507778881 723 GLGLPICKVIVERLGGRIEVKSQVGRGSRFTV 754
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
521-757 |
1.20e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 90.89 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 521 KDHEEELIQAR-RLAERAELKQSFLNNMSHEIRTPLNAIAGFANLlVYDPELSETEKREYAGIIDTNTKLLLKLVDDVLQ 599
Cdd:PRK13837 430 LETERDALERRlEHARRLEAVGTLASGIAHNFNNILGAILGYAEM-ALNKLARHSRAARYIDEIISAGARARLIIDQILA 508
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 600 LSRMETANmsfdLRRESVRHLLEAVYRTHSVLIKPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGK-FTSEGHI-- 676
Cdd:PRK13837 509 FGRKGERN----TKPFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQaMDGAGRVdi 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 677 -----------RLGYVRLPATREVSIYVEDTGIGIPQEEREMIFARFYkrSEFSQGVGLGLPICKVIVERLGGRIEVKSQ 745
Cdd:PRK13837 585 slsraklrapkVLSHGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFF--TTRAGGTGLGLATVHGIVSAHAGYIDVQST 662
|
250
....*....|..
gi 2507778881 746 VGRGSRFTVVLP 757
Cdd:PRK13837 663 VGRGTRFDVYLP 674
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
529-757 |
2.30e-17 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 85.85 E-value: 2.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 529 QARRLAERAELKQSFLNNMSHEIRTPLNAIAgFANLLVYD--PELSETEKREyAGIIDTNTKLLLKLVDDVLQLSRMETA 606
Cdd:NF040691 260 QIRQLEELSRLQQRFVSDVSHELRTPLTTIR-MAADVIHDsrDDFDPATARS-AELLHTELDRFESLLSDLLEISRFDAG 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 607 NMSFDLRRESVRHLLEAVYRTHSVLI-KPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFtSEGH---IRLGyvr 682
Cdd:NF040691 338 AAELDVEPVDLRPLVRRVVDALRQLAeRAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEH-GEGKpvvVTVA--- 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 683 lPATREVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKvivE--RL-GGRIEVKSQVGRGSRFTVV 755
Cdd:NF040691 414 -QDDTAVAVTVRDHGVGLKPGEVALVFDRFWRadpaRARTTGGTGLGLAIAL---EdaRLhGGWLEAWGRPGQGSQFRLT 489
|
..
gi 2507778881 756 LP 757
Cdd:NF040691 490 LP 491
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
8.85e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 76.28 E-value: 8.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGHIRLGYVRL---PAT-REVSIYVEDTGIGIPQEEREMIFARFYkrSEFSQGVGLGLPICKV 731
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIrtsPADdRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 2507778881 732 IVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
652-757 |
8.89e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 76.73 E-value: 8.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNAGKFTSEGhirlGYVRLPATR---EVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGL 724
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTG----GKLRIRAAQtpqEVRLDVEDSAPGVSDDQLARLFERFYRvessRNRASGGSGL 76
|
90 100 110
....*....|....*....|....*....|....
gi 2507778881 725 GLPICKVIVERLGGRIEVK-SQVGrGSRFTVVLP 757
Cdd:cd16946 77 GLAICHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
493-757 |
2.21e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 81.82 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 493 ELRYSTLPATVSGGKYIITGLLQNIQDVKDHEEELIQARRLAE--RAelkqsflnnMSHEIRTPLNAIAGFANLLVYDpe 570
Cdd:COG3290 149 VLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEalRA---------QRHDFRNHLHTISGLLQLGEYD-- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 571 lsetEKREYAGIIDTNTKLLLKLVDDVLQ-----------LSRMETANMSFDLRRESvrhlleavyrthsvliKPPLEFI 639
Cdd:COG3290 218 ----EALEYIDEISEELQELIDSLLSRIGnpvlaalllgkAARARERGIDLTIDIDS----------------DLPDLPL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 640 ADfpaEDafvhadrmrLTQVVTNFLNNA-----GKFTSEGHIRLGYVRLPatREVSIYVEDTGIGIPQEEREMIFARFY- 713
Cdd:COG3290 278 SD---TD---------LVTILGNLLDNAieaveKLPEEERRVELSIRDDG--DELVIEVEDSGPGIPEELLEKIFERGFs 343
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2507778881 714 -KRSEFSqgvGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:COG3290 344 tKLGEGR---GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
3.61e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 74.92 E-value: 3.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGHIRLGYVRLPATREVSIYVEDTGIGIPQEEREMIFARFY----KRSEFSQGVGLGLPICKV 731
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYterpANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 2507778881 732 IVERLGGRI--EVKSQVG--RGSRFTVVLP 757
Cdd:cd16953 81 IIEAHGGISvaENHNQPGqvIGARFTVQLP 110
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
652-757 |
6.90e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 74.07 E-value: 6.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNAGKFTSEGhirlGYVR--LPATR--EVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQ----GVG 723
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDG----GRIRciLEKFRlnRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 2507778881 724 LGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16925 77 LGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
9.75e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 73.78 E-value: 9.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEG-HIRLGYVRLPATREVSiyVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICK 730
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSdTITVRWSQEESGARLS--VEDTGPGIPPEHIPRLTERFYRvdieRCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|....*..
gi 2507778881 731 VIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16952 79 HVMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
525-757 |
1.99e-15 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 79.28 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 525 EELIQARRLAERAEL---KQSFLNNMSHEIRTPLNAIAGFANLLvYDPELsETEKREYA-GIIDTNTKLLLKLVDDVLQL 600
Cdd:PRK11006 186 QLLMVARDVTQMHQLegaRRNFFANVSHELRTPLTVLQGYLEMM-QDQPL-EGALREKAlHTMREQTQRMEGLVKQLLTL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 601 SRMETANMSfDLR-RESVRHLLEAVYRTHSVLI--KPPLEFIADfpaEDAFVHADRMRLTQVVTNFLNNAGKFTSEG-HI 676
Cdd:PRK11006 264 SKIEAAPTI-DLNeKVDVPMMLRVLEREAQTLSqgKHTITFEVD---NSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHI 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 677 RLGYVRLPATREVSiyVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRF 752
Cdd:PRK11006 340 TVRWQRVPQGAEFS--VEDNGPGIAPEHIPRLTERFYRvdkaRSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRF 417
|
....*
gi 2507778881 753 TVVLP 757
Cdd:PRK11006 418 SFVLP 422
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
621-756 |
2.69e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 73.05 E-value: 2.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 621 LEAVYRTHSVLIKpplefiADFPAEDAFvHADRMRLTQVVTNFLNNAGKFTSEgHIRLGYVRLPAtrEVSIYVEDTGIGI 700
Cdd:cd16954 10 LNKVYQRKGVSIS------LDISPELRF-PGERNDLMELLGNLLDNACKWCLE-FVEVTARQTDG--GLHLIVDDDGPGV 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2507778881 701 PQEEREMIFARFYKRSEFSQGVGLGLPICKVIVERLGGRIEV-KSQVGrGSRFTVVL 756
Cdd:cd16954 80 PESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
652-757 |
8.99e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 71.03 E-value: 8.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNA-----GKFTSEGHIRlgyVRLPATRE--VSIYVEDTGIGIPQEEREMIFARFYKRSEfsQGVGL 724
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaieGRPSDVGEVR---IRVEADQDgrIVLIVCDNGKGFPREMRHRATEPYVTTRP--KGTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 2507778881 725 GLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
680-757 |
9.95e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 70.87 E-value: 9.95e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2507778881 680 YVRLPATREVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16919 39 YRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
530-758 |
1.53e-14 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 76.60 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 530 ARRLAERAELKQSFLNNMSHEIRTPLNAIAGFANLL-----VYDPELSETEKREYA---GIIDTntklllklvddVLQLS 601
Cdd:PRK10549 230 ASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIqdgvrKFTPESVASLQAEVGtltKLVDD-----------LHQLS 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 602 RMETANMSFdlRRESVR--HLLE-AVYRTHSVLIKPPLEFIADFPaEDAFVHADRMRLTQVVTNFLNNAGKFTSEG---H 675
Cdd:PRK10549 299 LSDEGALAY--RKTPVDlvPLLEvAGGAFRERFASRGLTLQLSLP-DSATVFGDPDRLMQLFNNLLENSLRYTDSGgslH 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 676 IRLGYvrlpATREVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVK-SQVGrGS 750
Cdd:PRK10549 376 ISAEQ----RDKTLRLTFADSAPGVSDEQLQKLFERFYRtegsRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GV 450
|
....*...
gi 2507778881 751 RFTVVLPC 758
Cdd:PRK10549 451 SITVELPL 458
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
546-757 |
1.54e-14 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 76.81 E-value: 1.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 546 NMSHEIRTPLNAIAGFANLLvyDPELSETEKREYAGIIDTNTKLLLKLVDDVLQLSRMEtaNMSFDLRRESV------RH 619
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELL--QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLE--QRQELEVLEPValaallEE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 620 LLEAV---YRTHSVLIKpplefiadFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEGhirlGYVRLPATRE---VSIYV 693
Cdd:PRK11100 338 LVEAReaqAAAKGITLR--------LRPDDARVLGDPFLLRQALGNLLDNAIDFSPEG----GTITLSAEVDgeqVALSV 405
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2507778881 694 EDTGIGIPQEEREMIFARFYKRSEFSQGV---GLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK11100 406 EDQGPGIPDYALPRIFERFYSLPRPANGRkstGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-756 |
2.80e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 69.41 E-value: 2.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNA----GKFtSEGHIRLGYVRLPATREVSiyVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKV 731
Cdd:cd16976 1 IQQVLMNLLQNAldamGKV-ENPRIRIAARRLGGRLVLV--VRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 2507778881 732 IVERLGGRIEVKSQVGRGSRFTVVL 756
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
641-756 |
4.26e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 69.46 E-value: 4.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 641 DFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEGHIrLGYVRLPATREVSIYVEDTGIGIPQEEREMIFARFY----KRS 716
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKF-LGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYtledSRN 84
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2507778881 717 EFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVL 756
Cdd:cd16947 85 SAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
548-757 |
5.12e-14 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 75.21 E-value: 5.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 548 SHEIRTPLNAIAGFANllvYDPEL--SETEKREYAGIIdtntklllklVDDVLQLSRMetanmsfdlrresVRHLLEAVY 625
Cdd:PRK10364 245 AHEIRNPLSSIKGLAK---YFAERapAGGEAHQLAQVM----------AKEADRLNRV-------------VSELLELVK 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 626 RTH--------SVLIKPPLEFIA----------DFPAEDAF--VHADRMRLTQVVTNFLNNAGKFTSEGhirlGYVRLPA 685
Cdd:PRK10364 299 PTHlalqavdlNDLINHSLQLVSqdansreiqlRFTANDTLpeIQADPDRLTQVLLNLYLNAIQAIGQH----GVISVTA 374
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507778881 686 TR---EVSIYVEDTGIGIPQEEREMIFARFYKRSefSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK10364 375 SEsgaGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
530-757 |
6.20e-14 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 74.86 E-value: 6.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 530 ARRLAERAELKQSFLNNMSHEIRTPLNAIAGFANLLV-----YDPELSETEKREYAGIidtntkllLKLVDDVLQLSRME 604
Cdd:NF012163 230 ASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQdgirkFTPESLDSLQAEVGTL--------TKLVDDLHDLSMSD 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 605 TANMSFDLRRESVRHLLE-AVYRTHSVLIKPPLEFIADFPAEdAFVHADRMRLTQVVTNFLNNAGKFT-SEGHIRLGYVR 682
Cdd:NF012163 302 EGALAYQKASVDLVPLLEvEGGAFRERFASAGLELEVSLPDS-SLVFGDRDRLMQLFNNLLENSLRYTdSGGSLHISASQ 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507778881 683 LPatREVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:NF012163 381 RP--KEVTLTVADSAPGVSDEQLARLFERFYRvevsRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
2.03e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 66.93 E-value: 2.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGHIRLGYVRLPAT---REVSIYVEDTGIGIPQEEREMIFARFYKRSEFSqGVGLGLPICKVI 732
Cdd:cd16915 1 LITIVGNLIDNALDALAATGAPNKQVEVFLRdegDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 2507778881 733 VERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
518-756 |
1.39e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 67.79 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 518 QDVKDHEEELIQARRLAERAELKQSflnnMSHEIRTPLNAIagfaNLLVYDPELSETEK-----REYAGIIDTNTKLLLK 592
Cdd:COG4192 415 KNLRQTQDELIQAAKMAVVGQTMTS----LAHELNQPLNAM----SMYLFSAKKALEQEnyaqlPTSLDKIEGLIERMDK 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 593 LVDDVLQLSR-METANMSFDLRR--ESVRHLLEAVYRTHSVLIKPPlefiadfpaEDAFVHADRMRLTQVVTNFLNN--- 666
Cdd:COG4192 487 IIKSLRQFSRkSDTPLQPVDLRQviEQAWELVESRAKPQQITLHIP---------DDLMVQGDQVLLEQVLVNLLVNald 557
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 667 AGKFTSEGHIRLgyvrLPATREVSIYVEDTGIGIPQEERemIFARFYKRSEFsqGVGLGLPICKVIVERLGGRIEVKSQV 746
Cdd:COG4192 558 AVATQPQISVDL----LSNAENLRVAISDNGNGWPLVDK--LFTPFTTTKEV--GLGLGLSICRSIMQQFGGDLYLASTL 629
|
250
....*....|
gi 2507778881 747 GRGSrfTVVL 756
Cdd:COG4192 630 ERGA--MVIL 637
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
631-757 |
2.37e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 66.55 E-value: 2.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 631 LIKPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFtSEGHIRLGYVRLPATreVSIYVEDTGIGIPQEEREMIFA 710
Cdd:PRK10604 295 AVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY-AHSRVRVSLLLDGNQ--ACLIVEDDGPGIPPEERERVFE 371
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2507778881 711 RFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK10604 372 PFVRldpsRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-743 |
3.08e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 60.55 E-value: 3.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGhirlGYVRLPA---TREVSIYVEDTGIGIPQEEREMIFARFYK--RSEFSQ-GVGLGLPIC 729
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEG----GLIALQLeadTEGIELLVFDEGSGIPDYALNRVFERFYSlpRPHSGQkSTGLGLAFV 80
|
90
....*....|....
gi 2507778881 730 KVIVERLGGRIEVK 743
Cdd:cd16945 81 QEVAQLHGGRITLR 94
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
4.47e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 60.03 E-value: 4.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFtSEGHIRLGYVRlpATREVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKV 731
Cdd:cd16949 1 LARALENVLRNALRY-SPSKILLDISQ--DGDQWTITITDDGPGVPEDQLEQIFLPFYRvdsaRDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 2507778881 732 IVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
540-757 |
7.05e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 65.18 E-value: 7.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 540 KQS-FLNNMSHEIRTPLNAiagfanlLVYDPE--LSETE-KREYAGIIDTNtklllklvddVLQLSRME--TANMSF--- 610
Cdd:PRK09835 261 RQSnFSADIAHEIRTPITN-------LITQTEiaLSQSRsQKELEDVLYSN----------LEELTRMAkmVSDMLFlaq 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 611 -------------DLRRE--SVRHLLEAVYRTHSVlikpPLEFIADFPAedafVHADRMRLTQVVTNFLNNAGKFTSEGH 675
Cdd:PRK09835 324 adnnqlipekkmlDLADEvgKVFDFFEAWAEERGV----ELRFVGDPCQ----VAGDPLMLRRAISNLLSNALRYTPAGE 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 676 IRLgyVRLPAT-REVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKVIVERLGGRIEVKSQVgRGS 750
Cdd:PRK09835 396 AIT--VRCQEVdHQVQLVVENPGTPIAPEHLPRLFDRFYRvdpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGT 472
|
....*..
gi 2507778881 751 RFTVVLP 757
Cdd:PRK09835 473 RFVISLP 479
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
1.23e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.95 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEGH--IRLG-----YVRLPATRE---VSIYVEDTGIGIPQEEREMIFARFYKRSEfsQGVGLG 725
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeIILRtrtqrQVTLGHPRHrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRE--NGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 2507778881 726 LPICKVIVERLGGRIEVKSQVGRgSRFTVVLP 757
Cdd:cd16918 79 LAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
652-757 |
1.45e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 58.84 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNAGKFTSEGH---IRL----GYVRLpatrevsiYVEDTGIGIPQEEREMIFARFY---KRSEFSQG 721
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGkieIYSetneQGVVL--------SIKDFGIGIPEEDLPRVFDKGFtgeNGRNFQES 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 2507778881 722 VGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16948 74 TGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
532-757 |
1.56e-10 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 64.76 E-value: 1.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 532 RLAERAELKQSFLNNMSHEIRTPLnAI--AGFANLlvydpELSET--EKREYAGIIDTNTKLLLKLVDDVLQLSRMETAN 607
Cdd:TIGR03785 477 RLRQYTHYLENMSSRLSHELRTPV-AVvrSSLENL-----ELQALeqEKQKYLERAREGTERLSMILNNMSEATRLEQAI 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 608 MS-----FDLRResVRHLLEAVYRthsvLIKPPLEFIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEGhiRLGYVR 682
Cdd:TIGR03785 551 QSaevedFDLSE--VLSGCMQGYQ----MTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPED--GLIEVG 622
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 683 LPAT-REVSIYVEDTGIGIPQEEREMIFARFYK-RSEFSQGV---GLGLPICKVIVERLGGRIEVKSQV-GRGSRFTVVL 756
Cdd:TIGR03785 623 LSQNkSHALLTVSNEGPPLPEDMGEQLFDSMVSvRDQGAQDQphlGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISL 702
|
.
gi 2507778881 757 P 757
Cdd:TIGR03785 703 P 703
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
8.72e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 56.30 E-value: 8.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSeGHIRL-GYVRLPATRevsIYVEDTGIGIPQEEREMIFARFYK--RSEFSQGVGLGLPICKVI 732
Cdd:cd16950 1 LKRVLSNLVDNALRYGG-GWVEVsSDGEGNRTR---IQVLDNGPGIAPEEVDELFQPFYRgdNARGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 2507778881 733 VERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
524-757 |
1.27e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 60.48 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 524 EEELIQARRLAERaELkqsfLNNMSHEIRTPLNAIAGFANLL---VYDPELsetekREYAGIIdtntklllklvddvlql 600
Cdd:PRK11073 119 QEQLQHAQQVAAR-DL----VRGLAHEIKNPLGGLRGAAQLLskaLPDPAL-----TEYTKVI----------------- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 601 srMETANMsfdLR----------------RESVRHLLEAVYRTHSVLIKPPLEFIADF-PAEDAFVHaDRMRLTQVVTNF 663
Cdd:PRK11073 172 --IEQADR---LRnlvdrllgpqrpgthvTESIHKVAERVVQLVSLELPDNVRLIRDYdPSLPELAH-DPDQIEQVLLNI 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 664 LNNAGKFTSEGHirlGYVRLpATREV--------------SIYVEDTGIGIPQEEREMIFARFYKRSEfsQGVGLGLPIC 729
Cdd:PRK11073 246 VRNALQALGPEG---GTITL-RTRTAfqltlhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGRE--GGTGLGLSIA 319
|
250 260
....*....|....*....|....*...
gi 2507778881 730 KVIVERLGGRIEVKSQVGRgSRFTVVLP 757
Cdd:PRK11073 320 RNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
599-755 |
1.29e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 61.19 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 599 QLSRMET--------ANMSFD---LRRE--SVRHLLEA-------VYRTHSVLIKpplefiADFPAEDAFV--HADRMrl 656
Cdd:PRK10815 309 QISRISQqigyylhrASMRSEhnlLSRElhSVAPLLDNltsalnkVYQRKGVNIT------LDISPEITFVgeKNDFM-- 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 657 tQVVTNFLNNAGKFTSEghirlgYVRLPAT---REVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKVIV 733
Cdd:PRK10815 381 -EVMGNVLDNACKYCLE------FVEISARqtdEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREIT 453
|
170 180
....*....|....*....|..
gi 2507778881 734 ERLGGRIEVKSQVGRGSRFTVV 755
Cdd:PRK10815 454 EQYEGKISAGDSPLGGARMEVI 475
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
656-757 |
2.54e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 60.31 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNA-----GKFTSEGHIRLGYVRlpatREVSIYVEDTGIGIPQEEREMIFARFYkrSEFSQGVGLGLPICK 730
Cdd:PRK11086 434 LITILGNLIENAleavgGEEGGEISVSLHYRN----GWLHCEVSDDGPGIAPDEIDAIFDKGY--STKGSNRGVGLYLVK 507
|
90 100
....*....|....*....|....*..
gi 2507778881 731 VIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK11086 508 QSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
538-587 |
1.04e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 52.21 E-value: 1.04e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2507778881 538 ELKQSFLNNMSHEIRTPLNAIAGFANLLVYDPELSEtEKREYAGIIDTNT 587
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDE-EQREYLERIREEA 50
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
1.19e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 53.20 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFtSEGHIRLGYvRLPATReVSIYVEDTGIGIPQEEREMIFARFYK----RSEFSQGVGLGLPICKV 731
Cdd:cd16939 1 MARALDNLLRNALRY-AHRTVRIAL-LVSGGR-LTLIVEDDGPGIPAAARERVFEPFVRldpsRDRATGGFGLGLAIVHR 77
|
90 100
....*....|....*....|....*..
gi 2507778881 732 IVERLGGRIEV-KSQVGrGSRFTVVLP 757
Cdd:cd16939 78 VALWHGGHVECdDSELG-GACFRLTWP 103
|
|
| COG2984 |
COG2984 |
ABC-type uncharacterized transport system, periplasmic component [General function prediction ... |
31-346 |
2.19e-08 |
|
ABC-type uncharacterized transport system, periplasmic component [General function prediction only];
Pssm-ID: 442223 Cd Length: 284 Bit Score: 56.07 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 31 YKIALVH-SYEAGYPDAgrtREMLSDALARHGISCDFReyfLDCDDllSAKEEERCSDFIDDFTRWGARLVAVLDDQALY 109
Cdd:COG2984 3 KKIGILQiSEHPALDAA---REGFKDGLAEAGYGKNLK---LDYQN--AQGDQATAAQIAAKLVADKPDLIVAIGTPAAQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 110 SLMAcgnpRLHDLPVVFGGVNYPN-----RKLLERYPNVTGYADAPDYLNTIRMVERIM-GKSRVCVI-NRNSILDRFIW 182
Cdd:COG2984 75 AAAN----ATKDIPVVFTAVTDPVgaglvKSLEKPGGNVTGVSDLLPIEKQLELIKKLLpDAKRIGVLyNPSEANSVAQV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 183 NDLTRQLRGKGYEIYcgqigaHVSVHRglSSALPPAASGMSRenerfDTTAIVrLNGDSLsltqmawtghghrtlcLFTR 262
Cdd:COG2984 151 EELKKAAKKLGLELV------EATVTS--SNEIQQALQSLAG-----KVDAIY-VPTDNT----------------VVSA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 263 REFIAVHSANffHN-PCFeTVNEGFgTSDYALGGYFAPLETQLDDMAQGIAERLRGGTPD----RQVRYcaKRYVVNWHV 337
Cdd:COG2984 201 LEAIAKVAAR--AKiPVF-GGDDSS-VKAGALAGYGIDYYELGRQAAEMALRILKGEKPAdipvETPKK--FELVINLKT 274
|
....*....
gi 2507778881 338 LQRYGIPLS 346
Cdd:COG2984 275 AKALGITLP 283
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
517-757 |
3.97e-08 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 56.86 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 517 IQDvKDHE----EELIQARRLAERA-ELKQSFLNNMSHEIRTPLNAIAGFANLLVYD-------PELSE-TEKREYA-GI 582
Cdd:PRK10618 423 LRD-QDREvlvnKKLQQAQREYEKNqQARKAFLQNIGDELKQPLQSLAQLAAQLRQTsdeeqqqPELDQlAEQSDVLvRL 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 583 IDTNTKlllklvddvlqLSRMET-----ANMSF---DLRRESVRHLLEAVYR-----THSVLIKPPLEFIADFPAedafv 649
Cdd:PRK10618 502 VDNIQL-----------LNMLETqdwkpEQELFslqDLIDEVLPEVLPAIKRkglqlLIHNHLKAEQLRIGDRDA----- 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 650 hadrmrLTQVVTNFLNNAGKFTSEGHIRLGyVRLPATRE--VSIYVEDTGIGIPQEEREMI---FARFYKRSEFSQGVGL 724
Cdd:PRK10618 566 ------LRKILLLLLNYAITTTAYGKITLE-VDQDESSPdrLTIRILDTGAGVSIKELDNLhfpFLNQTQGDRYGKASGL 638
|
250 260 270
....*....|....*....|....*....|...
gi 2507778881 725 GLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK10618 639 TFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
540-587 |
4.35e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 50.26 E-value: 4.35e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2507778881 540 KQSFLNNMSHEIRTPLNAIAGFANLLVyDPELSEtEKREYAGIIDTNT 587
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLL-DTELSE-EQREYLETILREA 47
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
540-587 |
8.45e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 49.52 E-value: 8.45e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2507778881 540 KQSFLNNMSHEIRTPLNAIAGFANLLVyDPELSEtEKREYAGIIDTNT 587
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLR-DEKLDE-EQREYLETILRSA 47
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
541-757 |
9.70e-08 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 55.32 E-value: 9.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 541 QSFLNNMSHEIRTPL------NAIA----GfanllvydpELSETEKreyagiIDTNTKLLLKLVDDVLQLSRMETANmsf 610
Cdd:PRK09470 244 QRLLSDISHELRTPLtrlqlaTALLrrrqG---------ESKELER------IETEAQRLDSMINDLLVLSRNQQKN--- 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 611 dlrresvrHLLEAVYRTHS----VLIKPPLE-------FIADFPAEDAFVHADRMRLTQVVTNFLNNAGKFTSEgHIRLG 679
Cdd:PRK09470 306 --------HLERETFKANSlwseVLEDAKFEaeqmgksLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT-KIEVA 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 680 -YVRlpaTREVSIYVEDTGIGIPQEEREMIFARFYKRSEF----SQGVGLGLPICKVIVERLGGRIEV-KSQVGrGSRFT 753
Cdd:PRK09470 377 fSVD---KDGLTITVDDDGPGVPEEEREQIFRPFYRVDEArdreSGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLT 452
|
....
gi 2507778881 754 VVLP 757
Cdd:PRK09470 453 IWLP 456
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
679-757 |
1.10e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 52.58 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 679 GYVRLPATRE---VSIYVEDTGIGIPQE---------------------EREM---IFAR-FYKRSEFSQ--GVGLGLPI 728
Cdd:cd16916 70 GTITLRAEHQgnqVVIEVSDDGRGIDREkirekaierglitadeaatlsDDEVlnlIFAPgFSTAEQVTDvsGRGVGMDV 149
|
90 100
....*....|....*....|....*....
gi 2507778881 729 CKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16916 150 VKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-757 |
3.62e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 48.92 E-value: 3.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 656 LTQVVTNFLNNAGKFTSEG---HIRLGYvrlpATREVSIYVEDTGIGIPQEEREMIFARFYK--RSEFSQGVGLGLPICK 730
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENtriYITSFL----TDDVVNIMFKNPSSHPLDFKLEKLFERFYRgdNSRNTEGAGLGLSIAK 76
|
90 100
....*....|....*....|....*..
gi 2507778881 731 VIVERLGGRIEVKSQvGRGSRFTVVLP 757
Cdd:cd16923 77 AIIELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
455-757 |
5.08e-07 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 53.14 E-value: 5.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 455 LHPDDRERFYRSYR--ASENVHTHKGQYRFDFTGGGYEWWELRySTLPATVSGGKYIITGLLQNIQDVKdHEEELIQARr 532
Cdd:PRK13560 525 IHPADLEQVAAEVAefAAQGVDRFEQEYRILGKGGAVCWIDDQ-SAAERDEEGQISHFEGIVIDISERK-HAEEKIKAA- 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 533 LAEraelKQSFLNNMSHEIRTPLNAIAGFANLL---VYDPE----LSETEKREYAgiidtntklllkLVDDVLQLSRmeT 605
Cdd:PRK13560 602 LTE----KEVLLKEIHHRVKNNLQIISSLLDLQaekLHDEEakcaFAESQDRICA------------MALAHEKLYQ--S 663
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 606 ANMSFDLRRESVRHLLEAVYRThsvlikppleFIADFPAEDAFVHADRMRL------------TQVVTNFLNNAGKFTSE 673
Cdd:PRK13560 664 EDLADIDFLDYIESLTAHLKNS----------FAIDFGRIDCKIDADDGCLdidkaipcgliiSELLSNALKHAFPDGAA 733
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 674 GHIRLGyVRLPATREVSIYVEDTGIGIPqeeremifARFykrsEFSQGVGLGLPICKVIVERLGGRIEVKSQvgRGSRFT 753
Cdd:PRK13560 734 GNIKVE-IREQGDGMVNLCVADDGIGLP--------AGF----DFRAAETLGLQLVCALVKQLDGEIALDSR--GGARFN 798
|
....
gi 2507778881 754 VVLP 757
Cdd:PRK13560 799 IRFP 802
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
677-760 |
1.97e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.21 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 677 RLGYVRLPATREVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVL 756
Cdd:PRK13557 313 LAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
|
....
gi 2507778881 757 PCAE 760
Cdd:PRK13557 393 PASD 396
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
667-757 |
5.97e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 49.80 E-value: 5.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 667 AGKfTSEGHIRLGyvrlpATRE---VSIYVEDTGIGI----------------PQEEREM--------IFArfykrSEFS 719
Cdd:COG0643 303 AGK-PETGTITLS-----AYHEggrVVIEVSDDGRGLdlekirakaiekglitAEEAAALsdeellelIFA-----PGFS 371
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2507778881 720 --------QGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:COG0643 372 taeevtdlSGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
659-757 |
8.65e-06 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 48.75 E-value: 8.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 659 VVTNFLNNAGKFTSeghirlGYVRLPATRE---VSIYVEDTGIGIPQEEREMIFARFYK----RSefSQGVGLGLPICKV 731
Cdd:PRK09467 335 ALANLVVNAARYGN------GWIKVSSGTEgkrAWFQVEDDGPGIPPEQLKHLFQPFTRgdsaRG--SSGTGLGLAIVKR 406
|
90 100
....*....|....*....|....*.
gi 2507778881 732 IVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK09467 407 IVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
392-527 |
9.15e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 48.10 E-value: 9.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 392 ERRRKREAqhsLRYEHETLTLAISGSSTYVWRLEGEGII--CDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYRA 469
Cdd:COG2202 124 ERKRAEEA---LRESEERLRLLVENAPDGIFVLDLDGRIlyVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRR 200
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2507778881 470 SENVHTHKGQYRFDFTGGGYEWWELRYSTLPATVSGGKYIITGLLQNIQDVKDHEEEL 527
Cdd:COG2202 201 LLEGGRESYELELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
652-754 |
9.22e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.15 E-value: 9.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNAGKFTSEGhirlGYVRLPATRE---VSIYVEDTGIGIPQEEREMIFARFY--KRSEFSQG-VGLG 725
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEG----GTVSISIYDEeeyLYFEIWDNGHGFSEQDLKKALELFYrdDTSRRSGGhYGMG 76
|
90 100
....*....|....*....|....*....
gi 2507778881 726 LPICKVIVERLGGRIEVKSQVGRGSRFTV 754
Cdd:cd16975 77 LYIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
616-757 |
2.68e-05 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 45.41 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 616 SVRHLLEAVYR------THSVLIKPPLEFIADFPAEDAFVhadRMRLTQVVTNFLNNAGKFTSEGHIRLGYVRLP----- 684
Cdd:cd16929 1 SPKKVVEDASEearvlcDDYYLSSPELEIEGDPSIRFPYV---PSHLYYILFELLKNAMRATVESHGDDSDDLPPikvtv 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 685 --ATREVSIYVEDTGIGIPQEEREMIFARFYKRSEFSQ-----------------GVGLGLPICKVIVERLGGRIEVKSQ 745
Cdd:cd16929 78 akGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSM 157
|
170
....*....|..
gi 2507778881 746 VGRGSRFTVVLP 757
Cdd:cd16929 158 EGYGTDVYIYLK 169
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
654-757 |
6.24e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 43.18 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 654 MRLTQVVTNFLNNAGKFTSEGHIRLGYVRLPATREVSiyVEDTGIGIPQEEremifarfykrSEFSQGvGLGLPICKVIV 733
Cdd:cd16951 42 LVVNELLQNALKHAFSDREGGTITIRSVVDGDYLRIT--VIDDGVGLPQDE-----------DWPNKG-SLGLQIVRSLV 107
|
90 100
....*....|....*....|....
gi 2507778881 734 ERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16951 108 EGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
658-757 |
8.89e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 8.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 658 QVVTNFLNNAGKFTSEGHIRlgyVRLPAT-REVSIYVEDTGIGIPQEEREmifarfykrsefsQGVGLGLPICKVIVERL 736
Cdd:cd16917 3 RIVQEALTNALKHAGASRVR---VTLSYTaDELTLTVVDDGVGFDGPAPP-------------GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 2507778881 737 GGRIEVKSQVGRGSRFTVVLP 757
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
648-756 |
1.78e-04 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 42.06 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 648 FVHADRMRLTQVVTNFL-------NNAGKFT--------SEGHIRLGYVRLPATR-----EVSIYVEDTGIGIPQEEREM 707
Cdd:cd16938 4 VVVGDERRVFQVLLHMLgnllkmrNGGGNITfrvfleggSEDRSDRDWGPWRPSMsdesvEIRFEVEINDSGSPSIESAS 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2507778881 708 IFARFYKRS-EFSQGVGLGLPICKVIVERLGGRIEVKSQVGRGSRFTVVL 756
Cdd:cd16938 84 MRNSLNRRYnLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
429-497 |
1.85e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 40.79 E-value: 1.85e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2507778881 429 IICDPHFYDLIRHPRERI--TLDEIIHFLHPDDRERFYRSY-RASENVHTHKGQYRFDFTGGGYEWWELRYS 497
Cdd:pfam08447 2 IYWSPRFEEILGYTPEELlgKGESWLDLVHPDDRERVREALwEALKGGEPYSGEYRIRRKDGEYRWVEARAR 73
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
651-754 |
5.30e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 40.43 E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 651 ADRMRLTQVVTNFLNNAGKFTSEGHIRLGYVRLPATREVSIYVEDTGIGIPQEEREMifarfykRSEFSQ--GVGLGLPI 728
Cdd:cd16934 21 VRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEAL-------RDGFSTggGLGLGLGG 93
|
90 100
....*....|....*....|....*.
gi 2507778881 729 CKviveRLGGRIEVKSQVGRGSRFTV 754
Cdd:cd16934 94 VR----RLADEFDLHSAPGRGTVVVA 115
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
652-757 |
6.26e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.28 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 652 DRMRLTQVVTNFLNNAGKF---TSEGHIRLGYVRLPATREVSIYVEDTGIGIPQEEREMIFAR-FYKRSEFSQGVGLGLP 727
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEAslrSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQgVSTRADEPGEHGIGLY 508
|
90 100 110
....*....|....*....|....*....|
gi 2507778881 728 ICKVIVERLGGRIEVKSQVGRGSRFTVVLP 757
Cdd:PRK15053 509 LIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
689-760 |
6.69e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 42.70 E-value: 6.69e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2507778881 689 VSIYVEDTGIGIPQEEREMIFARFYKRSEFSqGVGLglpicKVIVERL------GGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG2972 373 LVITVEDNGVGMPEEKLEKLLEELSSKGEGR-GIGL-----RNVRERLklyygeEYGLEIESEPGEGTTVTIRIPLEE 444
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
351-760 |
3.72e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.66 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 351 EYTVMYIPFTERYHYTLLYIAVLSGLLLLLFIAFLIRSLSVERRRKREAQHSLRYEHETLTLAISGSSTYVWRLEGEGII 430
Cdd:COG3920 114 AALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 431 CDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRsyRASENVHTHKGQYRFDFTGGGYEWWELRYSTLPATVSGGKYII 510
Cdd:COG3920 194 LAAAALLALLLALELLLALLLLLLLLLALLLVLLA--ALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLA 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 511 TGLLQNIQDVKDHEEELIQArrLAERAELkqsfLNNMSHEIRTPLNAIAGFANL---LVYDPE----LSETEKReyagiI 583
Cdd:COG3920 272 AGIRLVITERKRAEEELEAS--LEEKELL----LRELHHRVKNNLQVVSSLLRLqarRADDPEareaLEESQNR-----I 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 584 DTntklllklvddvlqLSRM-ETANMSFDLRRESVRHLLEAVYRTH-SVLIKPPLEFIADfpAEDAFVHADR-----MRL 656
Cdd:COG3920 341 QA--------------LALVhELLYQSEDWEGVDLRDYLRELLEPLrDSYGGRGIRIELD--GPDVELPADAavplgLIL 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 657 TQVVTNFLNNAGKFTSEGHIRLGYVRlpATREVSIYVEDTGIGIPQEeremifarfykrSEFSQGVGLGLPICKVIVERL 736
Cdd:COG3920 405 NELVTNALKHAFLSGEGGRIRVSWRR--EDGRLRLTVSDNGVGLPED------------VDPPARKGLGLRLIRALVRQL 470
|
410 420
....*....|....*....|....
gi 2507778881 737 GGRIEVKSqvGRGSRFTVVLPCAE 760
Cdd:COG3920 471 GGTLELDR--PEGTRVRITFPLAE 492
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
687-760 |
6.18e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.22 E-value: 6.18e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507778881 687 REVSIYVEDTGIGIPQEEREmifarfykrsefSQGVGL-GLpicKVIVERLGGRIEVKSQVGRGSRFTVVLPCAE 760
Cdd:COG4585 192 GELTLTVRDDGVGFDPEAAP------------GGGLGLrGM---RERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
398-570 |
8.05e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 38.85 E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 398 EAQHSLRYEHETLTLAISGSSTYVWRLEGEGII--CDPHFYDLIRHPRERITLDEIIHFLHPDDRERFYRSYR-ASENVH 474
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRIlyVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRaALAGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507778881 475 THKGQYRFDFTGGGYEWWELRYSTLPATvSGGKYIITGLLQNIQDVKDHEEELIQA-RRLAERAELKQSFLNNMSHEIRT 553
Cdd:COG2202 81 VWRGELRNRRKDGSLFWVELSISPVRDE-DGEITGFVGIARDITERKRAEEALRESeERLRLLVENAPDGIFVLDLDGRI 159
|
170
....*....|....*..
gi 2507778881 554 pLNAIAGFANLLVYDPE 570
Cdd:COG2202 160 -LYVNPAAEELLGYSPE 175
|
|
| |
