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Conserved domains on  [gi|2514885047|ref|WP_284522423|]
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HAMP domain-containing sensor histidine kinase [Cytobacillus pseudoceanisediminis]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
113-352 7.79e-54

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 177.02  E-value: 7.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 113 HFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNE 192
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWkQRFNSNQIICINENMIRRVFGNLFSNAVRYGNkKDLHVYLTG 272
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLEL-DLPPELPLVYADPELLEQVLANLLDNAIKYSP-PGGTITISA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 273 YAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG2205   159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 77-121 4.19e-08

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


:

Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 48.98  E-value: 4.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2514885047  77 TKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
113-352 7.79e-54

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 177.02  E-value: 7.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 113 HFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNE 192
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWkQRFNSNQIICINENMIRRVFGNLFSNAVRYGNkKDLHVYLTG 272
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLEL-DLPPELPLVYADPELLEQVLANLLDNAIKYSP-PGGTITISA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 273 YAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG2205   159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 241-353 6.46e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.03  E-value: 6.46e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  241 INENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmDNQGSGLGL 320
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGG-RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSR-KIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2514885047  321 SSCKLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 246-350 9.44e-25

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 96.52  E-value: 9.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGnKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSCKL 325
Cdd:cd00075     1 LEQVLSNLLDNALKYS-PPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRR 77

                          90       100
                  ....*....|....*....|....*
gi 2514885047 326 IIEHHGGQIHAFQANHGGLGIRFTL 350
Cdd:cd00075    78 IVEAHGGRITVESEPGGGTTFTVTL 102
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 66-350 2.38e-24

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 103.24  E-value: 2.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  66 VVLTIFFHFNIT----KPIETLNSRLKKVNIGNSRTPLH-SRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLK 140
Cdd:TIGR01386 174 VLLTALLGWWITrlglEPLRRLSAVAARISPESLDQRLDpSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELR 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 141 TPLTSITGFVELLsmqknLTKMETQDYYELIMKKSrhtveLIEtfsmYTKNEAIVETI-------------DMRPMEAH- 206
Cdd:TIGR01386 254 TPLTNLLGQTQVA-----LSQPRTGEEYREVLESN-----LEE----LERLSRMVSDMlflaradngqlalERVRLDLAa 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 207 ------RLFENIATEYETELsgfnfrltwkqRFNSNQIICINENMIRRVFGNLFSNAVRY---GNKKDLHVyltgyAQDS 277
Cdd:TIGR01386 320 elakvaEYFEPLAEERGVRI-----------RVEGEGLVRGDPQMFRRAISNLLSNALRHtpdGGTITVRI-----ERRS 383

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514885047 278 YSY-FQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANHgglGIRFTL 350
Cdd:TIGR01386 384 DEVrVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG---KTRFIL 454
envZ PRK09467
osmolarity sensor protein; Provisional
 77-353 1.55e-23

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 100.76  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  77 TKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSmq 156
Cdd:PRK09467  178 NRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMS-- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 157 knltkmETQDYY-ELIMKKSRHTVELIETFSMYTK--NEAIVETIDMrpmeaHRLFENIAT-------EYETELSgfnfr 226
Cdd:PRK09467  256 ------EEDGYLaESINKDIEECNAIIEQFIDYLRtgQEMPMEMADL-----NALLGEVIAaesgyerEIETALQ----- 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 227 ltwkqrfNSNQIICINENMIRRVFGNLFSNAVRYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVD 306
Cdd:PRK09467  320 -------PGPIEVPMNPIAIKRALANLVVNAARYGNGW---IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGD 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2514885047 307 KSRqmDNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:PRK09467  390 SAR--GSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 242-354 1.41e-21

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 88.19  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 242 NENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSyFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmdnQGSGLGLS 321
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAG-EITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADKRGG---GGTGLGLS 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2514885047 322 SCKLIIEHHGGQIHAFQANHGGLGIRFTLPLKI 354
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 77-121 4.19e-08

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 48.98  E-value: 4.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2514885047  77 TKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
75-121 1.00e-06

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 45.32  E-value: 1.00e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2514885047   75 NITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48
HAMP pfam00672
HAMP domain;
71-121 1.24e-06

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 44.92  E-value: 1.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2514885047  71 FFHFNITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
113-352 7.79e-54

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 177.02  E-value: 7.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 113 HFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNE 192
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWkQRFNSNQIICINENMIRRVFGNLFSNAVRYGNkKDLHVYLTG 272
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLEL-DLPPELPLVYADPELLEQVLANLLDNAIKYSP-PGGTITISA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 273 YAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG2205   159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
22-353 2.59e-52

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 177.82  E-value: 2.59e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  22 IAAFFVLYIKSLFSDEGHALLGNIFSPVHFQMLLLLSFLMGLIFVVLTIFFHFNITKPIETLNSRLKKVNIGNSRTPLHS 101
Cdd:COG5002    59 LLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 102 RRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVEL 181
Cdd:COG5002   139 SALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 182 IETFSMYTKNEAIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRfNSNQIICINENMIRRVFGNLFSNAVRYG 261
Cdd:COG5002   219 VNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLP-EDPLLVLGDPDRLEQVLTNLLDNAIKYT 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 262 NKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANH 341
Cdd:COG5002   298 PEGG-TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPG 376

                         330
                  ....*....|..
gi 2514885047 342 GGLGIRFTLPLK 353
Cdd:COG5002   377 KGTTFTITLPLA 388
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
118-352 1.42e-46

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 161.23  E-value: 1.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 118 EERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKNltkMETQDYYELIMKKSRHTVELIETFSMYTKNEAIVET 197
Cdd:COG0642   100 LLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD---EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 198 IDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRfNSNQIICINENMIRRVFGNLFSNAVRYGnKKDLHVYLTGYAQDS 277
Cdd:COG0642   177 LEPEPVDLAELLEEVVELFRPLAEEKGIELELDLP-DDLPTVRGDPDRLRQVLLNLLSNAIKYT-PEGGTVTVSVRREGD 254

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2514885047 278 YSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmdNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG0642   255 RVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 120-352 3.92e-33

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 127.39  E-value: 3.92e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 120 RLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELLSM--QKNLTKM--ETQDYYELIMKKSRHTVELIETFSMYTKnea 193
Cdd:COG5000   191 ELLRAERLAAwgELARRIAHEIKNPLTPIQLSAERLRRklADKLEEDreDLERALDTIIRQVDRLKRIVDEFLDFAR--- 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 194 iVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRFNSNQIICiNENMIRRVFGNLFSNAVRYGNKKDlHVYLTGY 273
Cdd:COG5000   268 -LPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLA-DRDQLEQVLINLLKNAIEAIEEGG-EIEVSTR 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2514885047 274 AQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTvdkSRQmdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG5000   345 REDGRVRIEVSDNGPGIPEEVLERIFEPFFT---TKP---KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 102-353 1.03e-30

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 121.82  E-value: 1.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 102 RRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQ-KNLTKMETQDYYELIMKKSRHTVE 180
Cdd:COG4251   256 ELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDyGDKLDEEGREYLERIRDAAERMQA 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 181 LIE---TFSMYTKNEAIVETIDMRpmeahRLFENIATEYETELSGFNFRLTWkqrfNSNQIICINENMIRRVFGNLFSNA 257
Cdd:COG4251   336 LIDdllAYSRVGRQELEFEPVDLN-----ELLEEVLEDLEPRIEERGAEIEV----GPLPTVRGDPTLLRQVFQNLISNA 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 258 VRYGNKKD-LHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmDNQGSGLGLSSCKLIIEHHGGQIHA 336
Cdd:COG4251   407 IKYSRPGEpPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRD--EYEGTGIGLAIVKKIVERHGGRIWV 484

                         250
                  ....*....|....*..
gi 2514885047 337 FQANHGGLGIRFTLPLK 353
Cdd:COG4251   485 ESEPGEGATFYFTLPKA 501
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 116-354 4.32e-26

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 106.79  E-value: 4.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELlsMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEA 193
Cdd:COG5807   133 EAEDKLLRSEKLSVagELAAGIAHEIRNPLTSIKGFLQL--LQESREDSEREEYFNIIISEIDRINTIITELLVLSKPKK 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 194 ivetIDMRPMEAHRLFENIATEYETELSGFNFRLTwKQRFNSNQIICINENMIRRVFGNLFSNAVRYGNKKDlHVYLTGY 273
Cdd:COG5807   211 ----FNFKKLNLNDVLEDVIALLSTEAILKNISIK-YDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGG-NITIKTY 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 274 AQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSrqmdnqGSGLGLSSCKLIIEHHGGQIhAFQANHGGlGIRFTLPLK 353
Cdd:COG5807   285 VEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEE------GTGLGLSICKKIIEEHNGTI-EVESKPGK-GTTFTIYLP 356


                  .
gi 2514885047 354 I 354
Cdd:COG5807   357 L 357
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 241-353 6.46e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.03  E-value: 6.46e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  241 INENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmDNQGSGLGL 320
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGG-RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSR-KIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2514885047  321 SSCKLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 116-353 1.21e-25

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 105.65  E-value: 1.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHR-----EqvdMIAAIAHDLKTPLTSITGFVELLS--MQKNLTKMETQDYYELIMKKSRHTVELIETFSMY 188
Cdd:COG4191   128 ELQEQLVQSEKlaalgE---LAAGIAHEINNPLAAILGNAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAF 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 189 TKNEaiveTIDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRFNSNQIICiNENMIRRVFGNLFSNAV-RYGNKKDLH 267
Cdd:COG4191   205 SRRD----EEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLG-DPGQLEQVLLNLLINAIdAMEEGEGGR 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 268 VYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTvDKSRQmdnQGSGLGLSSCKLIIEHHGGQIHAfqANHGGLGIR 347
Cdd:COG4191   280 ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFT-TKPVG---KGTGLGLSISYGIVEKHGGRIEV--ESEPGGGTT 353


                  ....*...
gi 2514885047 348 FT--LPLK 353
Cdd:COG4191   354 FTitLPLA 361
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
116-353 5.87e-25

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 103.77  E-value: 5.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELLSMqkNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEA 193
Cdd:COG3852   121 RLERELRRAEKLAAvgELAAGLAHEIRNPLTGIRGAAQLLER--ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 194 ivetIDMRPMEAHRLFENIATEYETELSGfnfRLTWKQRFNSNQI-ICINENMIRRVFGNLFSNAVRYGNKK-------- 264
Cdd:COG3852   199 ----PEREPVNLHEVLERVLELLRAEAPK---NIRIVRDYDPSLPeVLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtr 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 265 -DLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTvdkSRQmdnQGSGLGLSSCKLIIEHHGGQIHAfqANHGG 343
Cdd:COG3852   272 vERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT---TKE---KGTGLGLAIVQKIVEQHGGTIEV--ESEPG 343

                         250
                  ....*....|..
gi 2514885047 344 LGIRFT--LPLK 353
Cdd:COG3852   344 KGTTFRiyLPLE 355
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 116-354 8.37e-25

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 104.45  E-value: 8.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHREQ----VDMIAA-IAHDLKTPLTSITGFVELLSMQKNltKMETQDYYELIMKKSRHTVELIETFSMYTK 190
Cdd:COG5808   224 TLLERVIQEINTQklelIGTFAAsTAHEIRNPLTSIKGFIQLLQEKYP--ELEDQKYFDIIQEEIQRINQIVSEFLVLGK 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 191 NEAIVETIDmrpmEAHRLFENIATEYETELSGFNFRLTwKQRFNSNQIICINENMIRRVFGNLFSNAVRYGNKKDlHVYL 270
Cdd:COG5808   302 PTAKKLELD----DLNELIEEILSIIDSEANLKNIRVE-KQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGG-KLTI 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 271 TGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKsrqmdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTL 350
Cdd:COG5808   376 SIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKE------GGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRL 449


                  ....
gi 2514885047 351 PLKI 354
Cdd:COG5808   450 PLKK 453
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 246-350 9.44e-25

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 96.52  E-value: 9.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGnKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSCKL 325
Cdd:cd00075     1 LEQVLSNLLDNALKYS-PPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRR 77

                          90       100
                  ....*....|....*....|....*
gi 2514885047 326 IIEHHGGQIHAFQANHGGLGIRFTL 350
Cdd:cd00075    78 IVEAHGGRITVESEPGGGTTFTVTL 102
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 66-350 2.38e-24

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 103.24  E-value: 2.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  66 VVLTIFFHFNIT----KPIETLNSRLKKVNIGNSRTPLH-SRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLK 140
Cdd:TIGR01386 174 VLLTALLGWWITrlglEPLRRLSAVAARISPESLDQRLDpSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELR 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 141 TPLTSITGFVELLsmqknLTKMETQDYYELIMKKSrhtveLIEtfsmYTKNEAIVETI-------------DMRPMEAH- 206
Cdd:TIGR01386 254 TPLTNLLGQTQVA-----LSQPRTGEEYREVLESN-----LEE----LERLSRMVSDMlflaradngqlalERVRLDLAa 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 207 ------RLFENIATEYETELsgfnfrltwkqRFNSNQIICINENMIRRVFGNLFSNAVRY---GNKKDLHVyltgyAQDS 277
Cdd:TIGR01386 320 elakvaEYFEPLAEERGVRI-----------RVEGEGLVRGDPQMFRRAISNLLSNALRHtpdGGTITVRI-----ERRS 383

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514885047 278 YSY-FQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANHgglGIRFTL 350
Cdd:TIGR01386 384 DEVrVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG---KTRFIL 454
envZ PRK09467
osmolarity sensor protein; Provisional
 77-353 1.55e-23

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 100.76  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  77 TKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSmq 156
Cdd:PRK09467  178 NRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMS-- 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 157 knltkmETQDYY-ELIMKKSRHTVELIETFSMYTK--NEAIVETIDMrpmeaHRLFENIAT-------EYETELSgfnfr 226
Cdd:PRK09467  256 ------EEDGYLaESINKDIEECNAIIEQFIDYLRtgQEMPMEMADL-----NALLGEVIAaesgyerEIETALQ----- 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 227 ltwkqrfNSNQIICINENMIRRVFGNLFSNAVRYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVD 306
Cdd:PRK09467  320 -------PGPIEVPMNPIAIKRALANLVVNAARYGNGW---IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGD 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2514885047 307 KSRqmDNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:PRK09467  390 SAR--GSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 116-353 6.37e-22

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 96.58  E-value: 6.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELLSMQKNltkMETQDYYELIMKKSRHTVELIETFSMYTKNEA 193
Cdd:COG5809   256 KLEELLRKSEKLSVvgELAAGIAHEIRNPLTSLKGFIQLLKDTID---EEQKTYLDIMLSELDRIESIISEFLVLAKPQA 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 194 I-VETIDMRP--------MEAHRLFENIATEYETELsgfnfrltwkqrfNSNQIICiNENMIRRVFGNLFSNAVRY-GNK 263
Cdd:COG5809   333 IkYEPKDLNTlieeviplLQPQALLKNVQIELELED-------------DIPDILG-DENQLKQVFINLLKNAIEAmPEG 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 264 KDLHVYlTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVdKSRqmdnqGSGLGLSSCKLIIEHHGGQIHAFQANHGG 343
Cdd:COG5809   399 GNITIE-TKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTT-KEK-----GTGLGLMVSYKIIEEHGGKITVESEVGKG 471

                         250
                  ....*....|
gi 2514885047 344 LGIRFTLPLK 353
Cdd:COG5809   472 TTFSITLPIK 481
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 242-354 1.41e-21

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 88.19  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 242 NENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSyFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmdnQGSGLGLS 321
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAG-EITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADKRGG---GGTGLGLS 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2514885047 322 SCKLIIEHHGGQIHAFQANHGGLGIRFTLPLKI 354
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
PRK10490 PRK10490
sensor protein KdpD; Provisional
 113-353 2.72e-21

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 95.10  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 113 HFNEMEE--RLyQAHREQV--DMIAAIAHDLKTPLTSITGFVELLsmqknltkmeTQDyyeLIMKKSRHTVELIETfsmy 188
Cdd:PRK10490  646 TLTASEEqaRL-ASEREQLrnALLAALSHDLRTPLTVLFGQAEIL----------TLD---LASEGSPHARQASEI---- 707

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 189 tkNEAIVETIdmrpmeahRLFENIATEYETELSGFNFRLTWKQ--------------RFNSNQI-ICINENM-------- 245
Cdd:PRK10490  708 --RQQVLNTT--------RLVNNLLDMARIQSGGFNLRKEWLTleevvgsalqmlepGLSGHPInLSLPEPLtlihvdgp 777

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 -IRRVFGNLFSNAVRY-GNKKDLHVYLTgyAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdnQGSGLGLSSC 323
Cdd:PRK10490  778 lFERVLINLLENAVKYaGAQAEIGIDAH--VEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAI--PGVGLGLAIC 853

                         250       260       270
                  ....*....|....*....|....*....|
gi 2514885047 324 KLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:PRK10490  854 RAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 248-352 2.85e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 84.68  E-value: 2.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 248 RVFGNLFSNAVRYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLII 327
Cdd:cd16949     3 RALENVLRNALRYSPSK---ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAI 79

                          90       100
                  ....*....|....*....|....*
gi 2514885047 328 EHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:cd16949    80 EQHGGKIKASNRKPGGLRVRIWLPA 104
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-351 7.63e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 83.27  E-value: 7.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNkkdLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmDNQGSGLGLSSCKL 325
Cdd:cd16950     1 LKRVLSNLVDNALRYGG---GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQR 75

                          90       100
                  ....*....|....*....|....*.
gi 2514885047 326 IIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16950    76 ISDAHGGSLTLANRAGGGLCARIELP 101
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 131-353 4.76e-19

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 87.86  E-value: 4.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 131 MIAAIAHDLKTPLTSITGFVELLSMqknltKMETQDYYELIMKKSRHTVELIET-FSMYTKNEAIVETidmrPMEAHRLF 209
Cdd:COG5805   290 LAAGIAHEIRNPLTSIKGFLQLLQP-----GIEDKEEYFDIMLSELDRIESIISeFLALAKPQAVNKE----KENINELI 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 210 ENIATEYETE--LSGFNFRLtwkQRFNSNQIICINENMIRRVFGNLFSNAVRY---GNKKDLHVYLTgyaqDSYSYFQIE 284
Cdd:COG5805   361 QDVVTLLETEaiLHNIQIRL---ELLDEDPFIYCDENQIKQVFINLIKNAIEAmpnGGTITIHTEEE----DNSVIIRVI 433

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 285 DNGVGVPSKDLSSLFLKFFTVDKsrqmdnQGSGLGLSSCKLIIEHHGGQIHaFQANHG-GLGIRFTLPLK 353
Cdd:COG5805   434 DEGIGIPEERLKKLGEPFFTTKE------KGTGLGLMVSYKIIENHNGTID-IDSKVGkGTTFTITLPLS 496
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
78-352 3.47e-18

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 85.45  E-value: 3.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  78 KPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGfvELLSMQK 157
Cdd:PRK10549  190 APVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRG--ELEAIQD 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 158 NLTKMETQDYYELIMKKSRHT--VELIETFSM-------YTKneaivETIDMRPMeahrlfeniateyeTELSGFNFRlt 228
Cdd:PRK10549  268 GVRKFTPESVASLQAEVGTLTklVDDLHQLSLsdegalaYRK-----TPVDLVPL--------------LEVAGGAFR-- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 229 wkQRFNSNQI---ICINENMIrrVFG----------NLFSNAVRYGNKK-DLHVylTGYAQDSYSYFQIEDNGVGVPSKD 294
Cdd:PRK10549  327 --ERFASRGLtlqLSLPDSAT--VFGdpdrlmqlfnNLLENSLRYTDSGgSLHI--SAEQRDKTLRLTFADSAPGVSDEQ 400

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2514885047 295 LSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:PRK10549  401 LQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
116-354 5.73e-18

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 85.02  E-value: 5.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 116 EMEERLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELLsmQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTK-NE 192
Cdd:PRK11360  376 RLQRRVARQERLAAlgELVAGVAHEIRNPLTAIRGYVQIW--RQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpRE 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIVETIDMRPM--EAHRLFE--------NIATEYETELSgfnfrltwkqrfnsnqIICINENMIRRVFGNLFSNAVRYGN 262
Cdd:PRK11360  454 SQWQPVSLNALveEVLQLFQtagvqarvDFETELDNELP----------------PIWADPELLKQVLLNILINAVQAIS 517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 263 KKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTvdkSRQmdnQGSGLGLSSCKLIIEHHGGQIHAfqANHG 342
Cdd:PRK11360  518 ARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFT---TKA---KGTGLGLALSQRIINAHGGDIEV--ESEP 589

                         250
                  ....*....|..
gi 2514885047 343 GLGIRFTLPLKI 354
Cdd:PRK11360  590 GVGTTFTLYLPI 601
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-351 6.98e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 78.27  E-value: 6.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 242 NENMIRRVFGNLFSNAVRY---GNKkdLHVYLTGYAQDSYSYFqiEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGL 318
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYtdtGGK--LRIRAAQTPQEVRLDV--EDSAPGVSDDQLARLFERFYRVESSRNRASGGSGL 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2514885047 319 GLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16946    77 GLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
PRK10604 PRK10604
sensor protein RstB; Provisional
 114-353 7.44e-18

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 84.27  E-value: 7.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 114 FNEMEERLYQ--AHREQvdMIAAIAHDLKTPLtsitgfVEL---LSMQKNLTKMETQ----DYYELimkksrhtVELIET 184
Cdd:PRK10604  198 FNQMADNINAliASKKQ--LIDGIAHELRTPL------VRLryrLEMSDNLSAAESQalnrDIGQL--------EALIEE 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 185 FSMYTK-----NEAIVETIDMRPMEAHRL--FENIATEYETELSgfnfrltwkqRFNSNQIICINENMIRRVFGNLFSNA 257
Cdd:PRK10604  262 LLTYARldrpqNELHLSEPDLPAWLSTHLadIQAVTPEKTVRLD----------TPHQGDYGALDMRLMERVLDNLLNNA 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 258 VRYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAF 337
Cdd:PRK10604  332 LRYAHSR---VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCD 408

                         250
                  ....*....|....*.
gi 2514885047 338 QANHGGLGIRFTLPLK 353
Cdd:PRK10604  409 ESELGGARFSFSWPVW 424
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
114-352 2.12e-17

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 83.06  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 114 FNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQ----KNLTKMETQdyyelIMKKSRHTVELIETFSMYT 189
Cdd:PRK09470  229 FNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRqgesKELERIETE-----AQRLDSMINDLLVLSRNQQ 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 190 KNEAIVETIDmrpmeAHRLFENIA--TEYETELSGFNFRLTW--KQRF-NSNQIICIN--ENMIRrvfgnlfsNAVRYGN 262
Cdd:PRK09470  304 KNHLERETFK-----ANSLWSEVLedAKFEAEQMGKSLTVSAppGPWPiNGNPNALASalENIVR--------NALRYSH 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 263 KkdlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANHG 342
Cdd:PRK09470  371 T---KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLG 447

                         250
                  ....*....|
gi 2514885047 343 GLGIRFTLPL 352
Cdd:PRK09470  448 GLRLTIWLPL 457
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
75-352 1.59e-16

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 80.59  E-value: 1.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  75 NITKPIETLNSRLKKVNIGNSRTPLhsrrkdEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTsitgfvells 154
Cdd:PRK09835  215 SVSRQIQNITSKDLDVRLDPQTVPI------ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPIT---------- 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 155 mqkNLTkmeTQDyyELIMKKSRHTVEL-------IETFSMYTK-------------NEAIVE--TIDMRPmEAHRLF--- 209
Cdd:PRK09835  279 ---NLI---TQT--EIALSQSRSQKELedvlysnLEELTRMAKmvsdmlflaqadnNQLIPEkkMLDLAD-EVGKVFdff 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 210 ENIATEYETELsgfnfrltwkqRFN-SNQIICINENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGV 288
Cdd:PRK09835  350 EAWAEERGVEL-----------RFVgDPCQVAGDPLMLRRAISNLLSNALRYTPAGE-AITVRCQEVDHQVQLVVENPGT 417

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514885047 289 GVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIhafQANHGGLGIRFTLPL 352
Cdd:PRK09835  418 PIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTV---AVTSDARGTRFVISL 478
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
130-354 5.01e-15

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 75.82  E-value: 5.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 130 DMIAAIAHDLKTPLTSITGFVE---------------LLSMQKNLTKMETqdyyeliMKKSRHTVELIETFSMYTKNEai 194
Cdd:PRK11006  206 NFFANVSHELRTPLTVLQGYLEmmqdqplegalrekaLHTMREQTQRMEG-------LVKQLLTLSKIEAAPTIDLNE-- 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 195 veTIDMrPMEAHRLfeniatEYETE-LSGFNFRLTwkqrFNSNQIICI--NENMIRRVFGNLFSNAVRYgNKKDLHVYLT 271
Cdd:PRK11006  277 --KVDV-PMMLRVL------EREAQtLSQGKHTIT----FEVDNSLKVfgNEDQLRSAISNLVYNAVNH-TPEGTHITVR 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 272 GYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:PRK11006  343 WQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422


                  ...
gi 2514885047 352 LKI 354
Cdd:PRK11006  423 ERL 425
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 246-352 6.21e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 69.83  E-value: 6.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNKKD--LHVYLTGYAQDSYS-YFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSS 322
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEvtLRVSLEEEEEDGVQlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2514885047 323 CKLIIEHHGGQIHAFqaNHGGLGIRF--TLPL 352
Cdd:cd16922    81 SKKLVELMGGDISVE--SEPGQGSTFtfTLPL 110
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 102-353 2.21e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 73.34  E-value: 2.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 102 RRKDEIgdlynhfNEMEERLYQAhREQVDMIAAIAHDLKTPLTSITGFVELLSMQknltkmETQDYyelIMKKSRHTVEL 181
Cdd:COG3290   171 RDRTEL-------ERLEEELEGV-KELAEALRAQRHDFRNHLHTISGLLQLGEYD------EALEY---IDEISEELQEL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 182 IETFSMYTKNEAIVETIdmrpmeahRLFENIATEyetelSGFNFRLTWKQRFNSnqiICINENMIRRVFGNLFSNAVRYG 261
Cdd:COG3290   234 IDSLLSRIGNPVLAALL--------LGKAARARE-----RGIDLTIDIDSDLPD---LPLSDTDLVTILGNLLDNAIEAV 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 262 NKKDLH---VYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSrqmdnQGSGLGLSSCKLIIEHHGGQIHAFQ 338
Cdd:COG3290   298 EKLPEEerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG-----EGRGLGLALVKQIVEKYGGTIEVES 372

                         250
                  ....*....|....*
gi 2514885047 339 ANHGGLGIRFTLPLK 353
Cdd:COG3290   373 EEGEGTVFTVRLPKE 387
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-349 3.25e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 68.00  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKL 325
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSD-TITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKH 79

                          90       100
                  ....*....|....*....|....
gi 2514885047 326 IIEHHGGQIHAfqANHGGLGIRFT 349
Cdd:cd16952    80 VMSRHDARLLI--ASELGKGSRFT 101
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 247-351 3.30e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 67.80  E-value: 3.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 247 RRVFGNLFSNAVRYgNKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmDNQGSGLGLSSCKLI 326
Cdd:cd16923     2 QRVFSNLLSNAIKY-SPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAI 78

                          90       100
                  ....*....|....*....|....*
gi 2514885047 327 IEHHGGQIHAFQANHGGLgIRFTLP 351
Cdd:cd16923    79 IELHGGSASAEYDDNHDL-FKVRLP 102
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-348 9.33e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 66.72  E-value: 9.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 242 NENMIRRVFGNLFSNAVRYgNKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmDNQGSGLGLS 321
Cdd:cd16975     1 DTLLLSRALINIISNACQY-APEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMGLY 78

                          90       100
                  ....*....|....*....|....*..
gi 2514885047 322 SCKLIIEHHGGQIHAFQANHGGLGIRF 348
Cdd:cd16975    79 IAKNLVEKHGGSLIIENSQKGGAEVTV 105
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-351 1.61e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 65.81  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNKKDLHVYLTGYAQDSYSY-FQIEDNGVGVPSKDLSSLFLKFFTVDKsrQMDNQGSGLGLSSCK 324
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWtFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78

                          90       100
                  ....*....|....*....|....*..
gi 2514885047 325 LIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16921    79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-335 1.95e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 66.38  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 242 NENMIRRVFGNLFSNAVRYGNKKDLhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLS 321
Cdd:cd16947    17 NTEALQRILKNLISNAIKYGSDGKF-LGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95

                          90
                  ....*....|....
gi 2514885047 322 SCKLIIEHHGGQIH 335
Cdd:cd16947    96 ITKRLAESMGGSIY 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 64-353 3.59e-13

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 70.26  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFfhfnITKPIETLNSRLKKVNIGNsRTPLHSRRKDEIGDLYNHFNEMEERLyqAHREQV-DMIAAIAHDLKTP 142
Cdd:PRK11100  198 IGAGVVWW----LNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKL--EGKAYVeQYVQTLTHELKSP 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 143 LTSITGFVELLsmQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEAIVETIDMRPMEAHRLFENIATEYETELSG 222
Cdd:PRK11100  271 LAAIRGAAELL--QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAA 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 223 FNFRLTWkqRFNSNQIICiNENMIRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKF 302
Cdd:PRK11100  349 KGITLRL--RPDDARVLG-DPFLLRQALGNLLDNAIDFSPEGG-TITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERF 424

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2514885047 303 FTV------DKSrqmdnqgSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLPLK 353
Cdd:PRK11100  425 YSLprpangRKS-------TGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 117-354 3.79e-13

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 70.70  E-value: 3.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 117 MEERLYQAHREQVD-----MIAAIAHDLKTPLTSITGFVELLSMQKNLTKmeTQDYYELIMKKSRHTVELIETFSMYTKN 191
Cdd:PRK11466  428 IEHRQARAEAEKASqaksaFLAAMSHEIRTPLYGILGTAQLLADNPALNA--QRDDLRAITDSGESLLTILNDILDYSAI 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 192 EAIVETIDM--RPMEAHRLFENIATEYETELSGFNFRL---------TWKQRfnsnqiiciNENMIRRVFGNLFSNAVRY 260
Cdd:PRK11466  506 EAGGKNVSVsdEPFEPRPLLESTLQLMSGRVKGRPIRLatdiaddlpTALMG---------DPRRIRQVITNLLSNALRF 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 261 GNKKdlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmdnQGSGLGLSSCKLIIEHHGGQIHAFQAN 340
Cdd:PRK11466  577 TDEG--SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTP 650

                         250
                  ....*....|....
gi 2514885047 341 HGGLGIRFTLPLKI 354
Cdd:PRK11466  651 EVGSCFCLRLPLRV 664
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
106-354 4.41e-13

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 70.53  E-value: 4.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  106 EIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSmQKNLTKMETQDYYELIMKKSRHTVELIETF 185
Cdd:PRK09959   690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEI 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  186 SMYTKNEAIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRFNSNQIICINENMIRRVFGNLFSNAVRYGNKKD 265
Cdd:PRK09959   769 LDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGA 848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  266 LHVYLT-GYAQDSYSYFQ--IEDNGVGVPSKDLSSLFLKFFTVDKSRQmdNQGSGLGLSSCKLIIEHHGGQIHAfqANHG 342
Cdd:PRK09959   849 VKITTSlGHIDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQ--QTGSGLGLMICKELIKNMQGDLSL--ESHP 924

                          250
                   ....*....|..
gi 2514885047  343 GLGIRFTLPLKI 354
Cdd:PRK09959   925 GIGTTFTITIPV 936
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 248-352 4.57e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 64.76  E-value: 4.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 248 RVFGNLFSNAVRYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLII 327
Cdd:cd16939     3 RALDNLLRNALRYAHRT---VRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79

                          90       100
                  ....*....|....*....|....*
gi 2514885047 328 EHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:cd16939    80 LWHGGHVECDDSELGGACFRLTWPR 104
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 248-352 7.66e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 64.13  E-value: 7.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 248 RVFGNLFSNAVRYGNKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSSCKLII 327
Cdd:cd16953     3 QVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82

                          90       100
                  ....*....|....*....|....*..
gi 2514885047 328 EHHGGQIHAFQANHGGL--GIRFTLPL 352
Cdd:cd16953    83 EAHGGISVAENHNQPGQviGARFTVQL 109
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-350 8.51e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 64.96  E-value: 8.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 249 VFGNLFSNAVRYGNKkdlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQmdnqGSGLGLSSCKLIIE 328
Cdd:cd16954    41 LLGNLLDNACKWCLE---FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVE 113

                          90       100
                  ....*....|....*....|..
gi 2514885047 329 HHGGQIHAFQANHGGLGIRFTL 350
Cdd:cd16954   114 QYGGELSLSDSPLGGARFEVVF 135
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-346 1.47e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 63.58  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 245 MIRRVFGNLFSNAVRY---GNKKDLHVYLTGYAQdsysyFQIEDNGVGVPSKDLSSLFLKFFTVDKsrqMDNQGSGLGLS 321
Cdd:cd16940    13 LLFLLLRNLVDNAVRYspqGSRVEIKLSADDGAV-----IRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLS 84

                          90       100
                  ....*....|....*....|....*
gi 2514885047 322 SCKLIIEHHGGQIHAFQANHGGLGI 346
Cdd:cd16940    85 IVKRIVELHGGQIFLGNAQGGGLEA 109
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-351 2.69e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 62.41  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSN---AVRYGN--KKDLHVYLTGYAQDSYSYFqIEDNGVGVPSKDLSSLFLKFFTVDKsrqmdnQGSGLGL 320
Cdd:cd16920     1 IQQVLINLVRNgieAMSEGGceRRELTIRTSPADDRAVTIS-VKDTGPGIAEEVAGQLFDPFYTTKS------EGLGMGL 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2514885047 321 SSCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16920    74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
PRK09303 PRK09303
histidine kinase;
126-351 9.19e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 65.36  E-value: 9.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 126 REQVD----MIAAIAHDLKTPLTSITGFVEllSMQKNLTKMETQDYYELIMKKSRHT---VELIETFSM------YTKNE 192
Cdd:PRK09303  145 LEQLKfkdrVLAMLAHDLRTPLTAASLALE--TLELGQIDEDTELKPALIEQLQDQArrqLEEIERLITdllevgRTRWE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIveTIDMRPMEAHRLFENIATEYEtelsgfNFRLTWKQRFNS---NQIICI--NENMIRRVFGNLFSNAVRYGNKKDlH 267
Cdd:PRK09303  223 AL--RFNPQKLDLGSLCQEVILELE------KRWLAKSLEIQTdipSDLPSVyaDQERIRQVLLNLLDNAIKYTPEGG-T 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 268 VYLTGYAQDS-YSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDnqGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGI 346
Cdd:PRK09303  294 ITLSMLHRTTqKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCF 371


                  ....*
gi 2514885047 347 RFTLP 351
Cdd:PRK09303  372 HFTLP 376
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 118-353 2.14e-11

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 64.96  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 118 EERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLsMQKNLTKmETQDYYELImkksrHT--VELIETFSmytkneaiv 195
Cdd:PRK11091  273 QDALEKASRDKTTFISTISHELRTPLNGIVGLSRIL-LDTELTA-EQRKYLKTI-----HVsaITLGNIFN--------- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 196 ETIDMRPMEAHRL--------FENIATEYETeLSGF-----NFRLTWKQRFNSNQIICINENMIRRVFGNLFSNAVRYGN 262
Cdd:PRK11091  337 DIIDMDKMERRKLqldnqpidFTDFLADLEN-LSGLqaeqkGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQ 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 263 KKdlHVYLT-GYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmDNQ---GSGLGLSSCKLIIEHHGGQIHAfq 338
Cdd:PRK11091  416 QG--GVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSH--GGKpatGTGIGLAVSKRLAQAMGGDITV-- 489

                         250
                  ....*....|....*
gi 2514885047 339 ANHGGLGIRFTLPLK 353
Cdd:PRK11091  490 TSEEGKGSCFTLTIH 504
PRK15347 PRK15347
two component system sensor kinase;
64-352 3.28e-11

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 64.66  E-value: 3.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFF--HFNITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDL---YNHF----------------------NE 116
Cdd:PRK15347  307 VLLTSVLFLllRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIakaYNQLldtlneqydtlenkvaertqalAE 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 117 MEERLYQAHREQVDMIAAIAHDLKTPLTSITGFVELLSMQKnLTkMETQDYYELIMKKSRHTVELIETFSMYTKNEA--- 193
Cdd:PRK15347  387 AKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTP-LT-AEQMDLADTARQCTLSLLAIINNLLDFSRIESgqm 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 194 --IVETIDMRPMeahrLFENIATeyeTELSGFNFRLTWKQRFNSN--QIICINENMIRRVFGNLFSNAVRYgnKKDLHVY 269
Cdd:PRK15347  465 tlSLEETALLPL----LDQAMLT---IQGPAQSKSLTLRTFVGAHvpLYLHLDSLRLRQILVNLLGNAVKF--TETGGIR 535

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 270 LTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDksrqMDNQGSGLGLSSCKLIIEHHGGQIHAFQANhgGLGIRFT 349
Cdd:PRK15347  536 LRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGGELTLFSTP--GVGSCFS 609


                  ...
gi 2514885047 350 LPL 352
Cdd:PRK15347  610 LVL 612
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
64-353 3.29e-11

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 64.27  E-value: 3.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFFHFNITKPIETLNSRLKKVNIGNSrTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIA------- 136
Cdd:COG2972   169 LALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkal 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 137 ------HDLKTPLTSITGFVELLSMQknltkmETQDYYELIMKKSRHtvelietfSMYTKNEAIVETIDMRPMEAH---- 206
Cdd:COG2972   248 qaqinpHFLFNTLNSIRWLAELEDPE------EAEEMLEALSKLLRY--------SLSKGDELVTLEEELELIKSYleiq 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 207 --RLFENIATEYETELSgfnfrltwkqrfnsnqiiCINENMIRRVFGNLFSNAVRYG---NKKDLHVYLTGYAQDSYSYF 281
Cdd:COG2972   314 klRFGDRLEVEIEIDEE------------------LLDLLIPKLILQPLVENAIEHGiepKEGGGTIRISIRKEGDRLVI 375

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2514885047 282 QIEDNGVGVPSKDLSSLFLKFftvdksrQMDNQGSGLGLSSCKLIIEHH---GGQIHAFQANHGGLGIRFTLPLK 353
Cdd:COG2972   376 TVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIPLE 443
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-352 1.23e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 57.85  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAV-RYGNKKDLHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSrqmdNQGSGLGLSSCK 324
Cdd:cd16976     1 IQQVLMNLLQNALdAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV----GKGTGLGLSISY 76

                          90       100
                  ....*....|....*....|....*...
gi 2514885047 325 LIIEHHGGQIHAfqANHGGLGIRFTLPL 352
Cdd:cd16976    77 GIVEEHGGRLSV--ANEEGAGARFTFDL 102
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
246-326 1.54e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 62.68  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRY---GNkkdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGLSS 322
Cdd:PRK10841  563 LQQVISNLLSNAIKFtdtGC-----IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI 637


                  ....*
gi 2514885047 323 C-KLI 326
Cdd:PRK10841  638 CeKLI 642
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
64-212 2.50e-10

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 61.67  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFFHFNITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPL 143
Cdd:COG2770   224 LALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLL 303

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2514885047 144 TSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEAIVETIDMRPMEAHRLFENI 212
Cdd:COG2770   304 EALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAE 372
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 127-193 2.62e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 55.68  E-value: 2.62e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2514885047 127 EQVDMIAAIAHDLKTPLTSITGFVELLsmQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEA 193
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-354 3.63e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 56.66  E-value: 3.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNKKDlHVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVdksrQMDNQGSGLGLSSCKL 325
Cdd:cd16943     4 LNQVLLNLLVNAAQAMEGRG-RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTT----KPVGEGTGLGLSLSYR 78

                          90       100
                  ....*....|....*....|....*....
gi 2514885047 326 IIEHHGGQIHAfqANHGGLGIRFTLPLKI 354
Cdd:cd16943    79 IIQKHGGTIRV--ASVPGGGTRFTIILPI 105
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 113-353 5.78e-10

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 60.27  E-value: 5.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 113 HFNEMEERLYQAHREQV--DMIAAIAHDLKTPLTSITGFVELLsMQKNLTKMETQDYYELIMKK--------------SR 176
Cdd:COG5806   184 ENILLRKELQRAEKLEVvsELAASIAHEVRNPLTVVRGFIQLL-QEPELSDEKRKQYIRIALEEldraeaiitdyltfAK 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 177 HTVELIETFSMYTKNEAIVETidMRPMeahrlfeniATEYETELSgfnfrltwkQRFNSNQIICINENMIRRVFGNLFSN 256
Cdd:COG5806   263 PQPEKLEKIDVSEELEHVIDV--LSPY---------ANMNNVEIQ---------TELEPGLYIEGDRQKLQQCLINIIKN 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 257 AVR-YGNKKDLHVYLtgYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKsrqmdnQGSGLGLSSCKLIIEHHGGQIH 335
Cdd:COG5806   323 GIEaMPNGGTLTIDV--SIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKE------KGTGLGTMVSYRIIEAMNGTIR 394

                         250       260
                  ....*....|....*....|
gi 2514885047 336 aFQANHgGLGIRFT--LPLK 353
Cdd:COG5806   395 -VESEV-GKGTTFTitLPLA 412
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 126-190 1.56e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 53.37  E-value: 1.56e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2514885047 126 REQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTKmETQDYYELIMKKSRHTVELIETFSMYTK 190
Cdd:cd00082     2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDE-EQREYLERIREEAERLLRLINDLLDLSR 65
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
133-354 2.02e-09

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 58.64  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 133 AAIAHDLKTPLTSITGFVELLSMQknlTKMETQDYyEL--IMKK-----SRHTVELIEtfsMYTKNEAIVETIDMRPMEA 205
Cdd:PRK10364  242 AGVAHEIRNPLSSIKGLAKYFAER---APAGGEAH-QLaqVMAKeadrlNRVVSELLE---LVKPTHLALQAVDLNDLIN 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 206 H--RLFENIATEYETELsgfnfrltwkqRFNSNQ---IICINENMIRRVFGNLFSNAVR-YGNKKDLHVylTGYAQDSYS 279
Cdd:PRK10364  315 HslQLVSQDANSREIQL-----------RFTANDtlpEIQADPDRLTQVLLNLYLNAIQaIGQHGVISV--TASESGAGV 381

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2514885047 280 YFQIEDNGVGVPSKDLSSLFLKFFTVDksrqmdNQGSGLGLSSCKLIIEHHGGQIHAfqANHGGLGIRFT--LPLKI 354
Cdd:PRK10364  382 KISVTDSGKGIAADQLEAIFTPYFTTK------AEGTGLGLAVVHNIVEQHGGTIQV--ASQEGKGATFTlwLPVNI 450
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-351 3.35e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 53.83  E-value: 3.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 249 VFGNLFSNAVRYGNKKD-LHVYLtgYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRQMdNQGSGLGLSSCKLII 327
Cdd:cd16948     9 IIGQIVSNALKYSKQGGkIEIYS--ETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNF-QESTGMGLYLVKKLC 85

                          90       100
                  ....*....|....*....|....
gi 2514885047 328 EHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16948    86 DKLGHKIDVESEVGEGTTFTITFP 109
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 64-343 5.35e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 57.39  E-value: 5.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFFHFN--ITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYN---HF------------NEMEER-LYQAH 125
Cdd:COG4192   337 LLAVLINYFYVRrrLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARllrVFrdqaiektqeleTEIEERkRIEKN 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 126 REQV--DMIAA------------IAHDLKTPLTSITGFvelLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKN 191
Cdd:COG4192   417 LRQTqdELIQAakmavvgqtmtsLAHELNQPLNAMSMY---LFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQ 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 192 EAIVETIDMRPMEAHRLFENIATEYETElsgfNFRLTWKQRFNSNQIICINENMIRRVFGNLFSNAVRYGN-KKDLHVYL 270
Cdd:COG4192   494 FSRKSDTPLQPVDLRQVIEQAWELVESR----AKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVAtQPQISVDL 569

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2514885047 271 tgYAQDSYSYFQIEDNGVGVPSKDlsSLFlKFFTVDKSrqmdnQGSGLGLSSCKLIIEHHGGQIHAFQANHGG 343
Cdd:COG4192   570 --LSNAENLRVAISDNGNGWPLVD--KLF-TPFTTTKE-----VGLGLGLSICRSIMQQFGGDLYLASTLERG 632
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 127-193 7.19e-09

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 51.80  E-value: 7.19e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2514885047  127 EQVDMIAAIAHDLKTPLTSITGFVELLSMQKNLTkmETQDYYELIMKKSRHTVELIETFSMYTKNEA 193
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSE--EQREYLETILREAERLLRLINDLLDLSRIEA 65
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 77-121 4.19e-08

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 48.98  E-value: 4.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2514885047  77 TKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 246-351 9.16e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 49.80  E-value: 9.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGN-----KKDLHVYLTGYAQDSysyfqIEDNGVGVPSKDLSSLFLKFFTVDKSRQMDNQGSGLGL 320
Cdd:cd16925     5 YERVVLNLLSNAFKFTPdggriRCILEKFRLNRFLLT-----VSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2514885047 321 SSCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16925    80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 246-351 1.61e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 49.07  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 246 IRRVFGNLFSNAVRYGNKKDL---HVYLTGYA-QDSYSYFQIEDNGVGVPSKDLSSLFLKFFTvDKSRqmdnqGSGLGLS 321
Cdd:cd16944     5 ISQVLTNILKNAAEAIEGRPSdvgEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVT-TRPK-----GTGLGLA 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 2514885047 322 SCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16944    79 IVKKIMEEHGGRISLSNREAGGACIRIILP 108
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
22-141 2.11e-07

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 52.33  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  22 IAAFFVLYIKSLFSDEGHALLGNIFSPVHFQMLLLLSFLMGLIFVVLTIFFHFNITKPIETLNSRLKKVNIGNSRTPLHS 101
Cdd:COG0840   152 LLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDV 231

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2514885047 102 RRKDEIGDLYNHFNEMEERLyqahREQVDMIAAIAHDLKT 141
Cdd:COG0840   232 DSKDEIGQLADAFNRMIENL----RELVGQVRESAEQVAS 267
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 64-201 8.89e-07

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 50.65  E-value: 8.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFFHFNITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHDLKTPL 143
Cdd:COG3850   130 LALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLAL 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2514885047 144 TSITGFVELLSMQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNEAIVETIDMR 201
Cdd:COG3850   210 LDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLL 267
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
75-121 1.00e-06

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 45.32  E-value: 1.00e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2514885047   75 NITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48
HAMP pfam00672
HAMP domain;
71-121 1.24e-06

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 44.92  E-value: 1.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2514885047  71 FFHFNITKPIETLNSRLKKVNIGNSRTPLHSRRKDEIGDLYNHFNEMEERL 121
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
64-333 2.41e-06

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 48.81  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047  64 IFVVLTIFFHFN----ITKPIETLNSRLKKVNIGN-SRTPLHSRrKDEIGDLYNHFNEMEERLYQAHREQVDMIAAIAHD 138
Cdd:PRK10755   69 VMVSLTLLICFQavrwITRPLAELQKELEARTADNlTPIAIHSS-TLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHE 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 139 LKTPLTSITGFVELLSMQKNltkmetQDYYELIMKKSR--HTVELI-------ETFSM--YTKNEAIVETIDmrPMEAhr 207
Cdd:PRK10755  148 LRTPLAGIRLHLELLEKQHH------IDVAPLIARLDQmmHTVEQLlqlaragQSFSSghYQTVKLLEDVIL--PSQD-- 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 208 lfeniatEYETELSGFNFRLTWKQRFnSNQIICINENMIRRVFGNLFSNAVRYGNK-KDLHVYLTgyAQDSYSYFQIEDN 286
Cdd:PRK10755  218 -------ELSEMLEQRQQTLLLPESA-ADITVQGDATLLRLLLRNLVENAHRYSPEgSTITIKLS--QEDGGAVLAVEDE 287

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2514885047 287 GVGVPSKDLSSLFLKFftvdksRQMDNQ--GSGLGLSSCKLIIEHHGGQ 333
Cdd:PRK10755  288 GPGIDESKCGELSKAF------VRMDSRygGIGLGLSIVSRITQLHHGQ 330
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 283-335 3.70e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 45.08  E-value: 3.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2514885047 283 IEDNGVGVPSKDLSSLFLKFFTvdkSRQmdnQGSGLGLSSCKLIIEHHGGQIH 335
Cdd:cd16918    48 VIDNGPGIPPDLQDTIFYPMVS---GRE---NGTGLGLAIAQNIVSQHGGVIE 94
PRK10337 PRK10337
sensor protein QseC; Provisional
 252-344 1.06e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 46.95  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 252 NLFSNAVRYGNKKDLhVYLTGYAQdsysYFQIEDNGVGVPSKDLSSLFLKFFtvdKSRQMDNQGSGLGLSSCKLIIEHHG 331
Cdd:PRK10337  359 NLLDNAIRYSPQGSV-VDVTLNAR----NFTVRDNGPGVTPEALARIGERFY---RPPGQEATGSGLGLSIVRRIAKLHG 430

                          90
                  ....*....|...
gi 2514885047 332 GQIHAFQANHGGL 344
Cdd:PRK10337  431 MNVSFGNAPEGGF 443
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-346 1.24e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.60  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 245 MIRRVFGNLFSNAVRYGNKKDLhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSrQMDNQGSGLGLSSCK 324
Cdd:cd16945     4 LLRQAINNLLDNAIDFSPEGGL-IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRP-HSGQKSTGLGLAFVQ 81

                          90       100
                  ....*....|....*....|..
gi 2514885047 325 LIIEHHGGQIHAFQANHGGLGI 346
Cdd:cd16945    82 EVAQLHGGRITLRNRPDGVLAF 103
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 252-354 9.19e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 44.45  E-value: 9.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 252 NLFSNAVRYGNKKDLHVYLTGYAQDSYSY---FQIEDNGVGVPSKDLSSLFLKFftvdksRQMDNQ------GSGLGLSS 322
Cdd:PRK11107  415 NLVGNAIKFTESGNIDILVELRALSNTKVqleVQIRDTGIGISERQQSQLFQAF------RQADASisrrhgGTGLGLVI 488

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2514885047 323 CKLIIEHHGGQIHAFQANHGGLGIRFTLPLKI 354
Cdd:PRK11107  489 TQKLVNEMGGDISFHSQPNRGSTFWFHLPLDL 520
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 120-354 1.14e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 44.15  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 120 RLYQAHRE-------QVDMIAAIAHDLKTPLTSITGFVELLsmQKNLTKMETQDYYELIMKKSRHTVELIETFSMYTKNE 192
Cdd:PRK10618  435 KLQQAQREyeknqqaRKAFLQNIGDELKQPLQSLAQLAAQL--RQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLE 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 193 AIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWKQRFNSNQIICINENMIRRVFGNLFSNAV---RYGnKKDLHVY 269
Cdd:PRK10618  513 TQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAItttAYG-KITLEVD 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 270 LTGYAQDSYsYFQIEDNGVGVPSKDLSSL---FLKFFTVDKSRqmdnQGSGLGLSSCKLIIEHHGGQIhAFQANHgGLGI 346
Cdd:PRK10618  592 QDESSPDRL-TIRILDTGAGVSIKELDNLhfpFLNQTQGDRYG----KASGLTFFLCNQLCRKLGGHL-TIKSRE-GLGT 664


                  ....*...
gi 2514885047 347 RFTLPLKI 354
Cdd:PRK10618  665 RYSIHLKM 672
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-350 1.63e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.35  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 249 VFGNLFSNAV------RYGNKKdlhVYLTGYAQDSYSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSRqmdnqGSGLGLSS 322
Cdd:cd16915     4 IVGNLIDNALdalaatGAPNKQ---VEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-----ERGIGLAL 75

                          90       100
                  ....*....|....*....|....*...
gi 2514885047 323 CKLIIEHHGGQIhaFQANHGGLGIRFTL 350
Cdd:cd16915    76 VRQSVERLGGSI--TVESEPGGGTTFSI 101
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 278-351 5.78e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 39.29  E-value: 5.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514885047 278 YSYFQIEDNGVGVPSKDLSSLFLKFFTVDKSrqmdNQGSGLGLSSCKLIIEHHGGQIHAFQANHGGLGIRFTLP 351
Cdd:cd16919    47 YVCLEVSDTGSGMPAEVLRRAFEPFFTTKEV----GKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
278-334 1.40e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.43  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2514885047 278 YSYFQIEDNGVGVPSKDLSSLFLKFFTvdkSRqmdNQGSGLGLSSCKLIIEHHGGQI 334
Cdd:PRK13837  607 YVLLRVSDTGAGIDEAVLPHIFEPFFT---TR---AGGTGLGLATVHGIVSAHAGYI 657
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
248-352 5.74e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.06  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 248 RVFGNLFSNAVRYGNKKDLHVYLTgYAQDSYSyFQIEDNGVGvpskdlsslflkfFTVDKSRqmdnqGSGLGLSSCKLII 327
Cdd:COG4585   165 RIVQEALTNALKHAGATRVTVTLE-VDDGELT-LTVRDDGVG-------------FDPEAAP-----GGGLGLRGMRERA 224

                          90       100
                  ....*....|....*....|....*
gi 2514885047 328 EHHGGQIHAFQANHGGLGIRFTLPL 352
Cdd:COG4585   225 EALGGTLTIGSAPGGGTRVRATLPL 249
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 192-353 6.23e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 38.35  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 192 EAIVETIDMRPMEAHRLFENIATEYETELSGFNFRLTWK---QRFNSNQII----CINEnmirrvfgnLFSNAVRYG--N 262
Cdd:COG3920   348 ELLYQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDgpdVELPADAAVplglILNE---------LVTNALKHAflS 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514885047 263 KKDLHVYLTGYAQDSYSYFQIEDNGVGVPSkdlsslflkffTVDKSRqmdnqGSGLGLSSCKLIIEHHGGQIHafQANHG 342
Cdd:COG3920   419 GEGGRIRVSWRREDGRLRLTVSDNGVGLPE-----------DVDPPA-----RKGLGLRLIRALVRQLGGTLE--LDRPE 480

                         170
                  ....*....|.
gi 2514885047 343 GLGIRFTLPLK 353
Cdd:COG3920   481 GTRVRITFPLA 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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