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Conserved domains on  [gi|2515253459|ref|WP_284671560|]
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MoxR family ATPase [Pseudomonas sp. HR1]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 2-259 2.11e-54

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 177.67  E-value: 2.11e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459   2 AFQGTERYVATAELSLAVNAAIQLGRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEYDAVSrlrds 81
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQ----- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  82 qlgdpqvQEVANYIKPGKLwdaFTaedpVVLLIDEIDKADIEFPNDLLLELDRMEFHVYetGETIRAQRRPVIIITSN-- 159
Cdd:COG0714    82 -------QTGEFEFRPGPL---FA----NVLLADEINRAPPKTQSALLEAMEERQVTIP--GGTYKLPEPFLVIATQNpi 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 160 ---NEKELPDAFLRRC-FFHFIRFPERDTLERIVQVHY--------PDLQG-------RLVKE----------ALDLFLD 210
Cdd:COG0714   146 eqeGTYPLPEAQLDRFlLKLYIGYPDAEEEREILRRHTgrhlaevePVLSPeellalqELVRQvhvseavldyIVDLVRA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2515253459 211 LRSVPGLKKKPSTSELVDWLALLlgdeAAQRALHGEGGLPP-----LAGALVKN 259
Cdd:COG0714   226 TREHPDLRKGPSPRASIALLRAA----RALALLDGRDYVTPddvkaVAGPVLKH 275
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 2-259 2.11e-54

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 177.67  E-value: 2.11e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459   2 AFQGTERYVATAELSLAVNAAIQLGRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEYDAVSrlrds 81
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQ----- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  82 qlgdpqvQEVANYIKPGKLwdaFTaedpVVLLIDEIDKADIEFPNDLLLELDRMEFHVYetGETIRAQRRPVIIITSN-- 159
Cdd:COG0714    82 -------QTGEFEFRPGPL---FA----NVLLADEINRAPPKTQSALLEAMEERQVTIP--GGTYKLPEPFLVIATQNpi 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 160 ---NEKELPDAFLRRC-FFHFIRFPERDTLERIVQVHY--------PDLQG-------RLVKE----------ALDLFLD 210
Cdd:COG0714   146 eqeGTYPLPEAQLDRFlLKLYIGYPDAEEEREILRRHTgrhlaevePVLSPeellalqELVRQvhvseavldyIVDLVRA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2515253459 211 LRSVPGLKKKPSTSELVDWLALLlgdeAAQRALHGEGGLPP-----LAGALVKN 259
Cdd:COG0714   226 TREHPDLRKGPSPRASIALLRAA----RALALLDGRDYVTPddvkaVAGPVLKH 275
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 29-180 3.99e-11

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 59.14  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  29 LLVKGEPGTGKTLLAEQVAESQGARLITWhvksttkaqqglyeydAVSRLRDSQLGdpqvqEVANYIKpgKLWDAFTAED 108
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEI----------------SGSELVSKYVG-----ESEKRLR--ELFEAAKKLA 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 109 PVVLLIDEIDK----------ADIEFPNDLLLELdrMEfhvyetGETIRAQRRPVIIITsnNEKELPDAFLRRCFFHFIR 178
Cdd:pfam00004  58 PCVIFIDEIDAlagsrgsggdSESRRVVNQLLTE--LD------GFTSSNSKVIVIAAT--NRPDKLDPALLGRFDRIIE 127


                  ..
gi 2515253459 179 FP 180
Cdd:pfam00004 128 FP 129
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 26-181 5.73e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.47  E-value: 5.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  26 GRPLLVKGEPGTGKTLLAEQVA---ESQGARLITWHVKSttkaqqgLYEYDAVSRLRDSQLGDpQVQEVANYIKPGklwd 102
Cdd:cd00009    19 PKNLLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASD-------LLEGLVVAELFGHFLVR-LLFELAEKAKPG---- 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2515253459 103 aftaedpvVLLIDEIDKADIEFPNDLLLELDRMEFHVYETGETIraqrrpVIIITSNNEKELPDAFLRRCFFHFIRFPE 181
Cdd:cd00009    87 --------VLFIDEIDSLSRGAQNALLRVLETLNDLRIDRENVR------VIGATNRPLLGDLDRALYDRLDIRIVIPL 151
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 26-180 3.83e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 54.30  E-value: 3.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459   26 GRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEYDAVSRLRDSQLGDPQVQEVANYIKpgklwDAFt 105
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALA-----LAR- 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2515253459  106 AEDPVVLLIDEIDKADIEFPNDLLLELDRMEFhvyetGETIRAQRRPVIIITSNNEKELPDAFLRRCFFHFIRFP 180
Cdd:smart00382  76 KLKPDVLILDEITSLLDAEQEALLLLLEELRL-----LLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLL 145
ycf46 CHL00195
Ycf46; Provisional
 18-192 1.84e-04

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 42.70  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  18 AVNAAIQLGRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEydavSRLRdsqlgdpQVQEVANYIKP 97
Cdd:CHL00195  251 ASNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESE----SRMR-------QMIRIAEALSP 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  98 GKLWdaftaedpvvllIDEIDKA--DIEFPNDllleldrmefhvyeTGETIRA----------QRRPVIII-TSNNEKEL 164
Cdd:CHL00195  320 CILW------------IDEIDKAfsNSESKGD--------------SGTTNRVlatfitwlseKKSPVFVVaTANNIDLL 373

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2515253459 165 PDAFLRRCFFH---FIRFPERDTLERIVQVH 192
Cdd:CHL00195  374 PLEILRKGRFDeifFLDLPSLEEREKIFKIH 404
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 14-138 3.32e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 38.38  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  14 ELSLAVNAAIQLGRPL--LVKGEPGTGKTLLA-------EQVAESQGARLITWHVksttKAQQGLYEYDAVSRLRDS-QL 83
Cdd:TIGR02928  26 ELAKALRPILRGSRPSnvFIYGKTGTGKTAVTkyvmkelEEAAEDRDVRVVTVYV----NCQILDTLYQVLVELANQlRG 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2515253459  84 GDPQV-------QEVANyikpgKLWDAFTAEDPVVLLI-DEIDKADIEfPNDLLLELDRMEFH 138
Cdd:TIGR02928 102 SGEEVpttglstSEVFR-----RLYKELNERGDSLIIVlDEIDYLVGD-DDDLLYQLSRARSN 158
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 2-259 2.11e-54

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 177.67  E-value: 2.11e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459   2 AFQGTERYVATAELSLAVNAAIQLGRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEYDAVSrlrds 81
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQ----- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  82 qlgdpqvQEVANYIKPGKLwdaFTaedpVVLLIDEIDKADIEFPNDLLLELDRMEFHVYetGETIRAQRRPVIIITSN-- 159
Cdd:COG0714    82 -------QTGEFEFRPGPL---FA----NVLLADEINRAPPKTQSALLEAMEERQVTIP--GGTYKLPEPFLVIATQNpi 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 160 ---NEKELPDAFLRRC-FFHFIRFPERDTLERIVQVHY--------PDLQG-------RLVKE----------ALDLFLD 210
Cdd:COG0714   146 eqeGTYPLPEAQLDRFlLKLYIGYPDAEEEREILRRHTgrhlaevePVLSPeellalqELVRQvhvseavldyIVDLVRA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2515253459 211 LRSVPGLKKKPSTSELVDWLALLlgdeAAQRALHGEGGLPP-----LAGALVKN 259
Cdd:COG0714   226 TREHPDLRKGPSPRASIALLRAA----RALALLDGRDYVTPddvkaVAGPVLKH 275
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 29-180 3.99e-11

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 59.14  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  29 LLVKGEPGTGKTLLAEQVAESQGARLITWhvksttkaqqglyeydAVSRLRDSQLGdpqvqEVANYIKpgKLWDAFTAED 108
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEI----------------SGSELVSKYVG-----ESEKRLR--ELFEAAKKLA 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 109 PVVLLIDEIDK----------ADIEFPNDLLLELdrMEfhvyetGETIRAQRRPVIIITsnNEKELPDAFLRRCFFHFIR 178
Cdd:pfam00004  58 PCVIFIDEIDAlagsrgsggdSESRRVVNQLLTE--LD------GFTSSNSKVIVIAAT--NRPDKLDPALLGRFDRIIE 127


                  ..
gi 2515253459 179 FP 180
Cdd:pfam00004 128 FP 129
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 26-181 5.73e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.47  E-value: 5.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  26 GRPLLVKGEPGTGKTLLAEQVA---ESQGARLITWHVKSttkaqqgLYEYDAVSRLRDSQLGDpQVQEVANYIKPGklwd 102
Cdd:cd00009    19 PKNLLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASD-------LLEGLVVAELFGHFLVR-LLFELAEKAKPG---- 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2515253459 103 aftaedpvVLLIDEIDKADIEFPNDLLLELDRMEFHVYETGETIraqrrpVIIITSNNEKELPDAFLRRCFFHFIRFPE 181
Cdd:cd00009    87 --------VLFIDEIDSLSRGAQNALLRVLETLNDLRIDRENVR------VIGATNRPLLGDLDRALYDRLDIRIVIPL 151
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 28-172 5.37e-10

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.15  E-value: 5.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  28 PLLVKGEPGTGKTLLAEQVAesqgARLITWHV------KSTTKAQ-QGLYEYDAV-SRLRDSQLGDpqvqevanyikpgk 99
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLA----AALSNRPVfyvqltRDTTEEDlFGRRNIDPGgASWVDGPLVR-------------- 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2515253459 100 lwdafTAEDPVVLLIDEIDKADIEFPNDLLLELDRMEFHVYETGETIRAQRRPVIIITSNNE-----KELPDAFLRRC 172
Cdd:pfam07728  63 -----AAREGEIAVLDEINRANPDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPldrglNELSPALRSRF 135
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 23-207 1.25e-09

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 58.00  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  23 IQLGRPLLVKGEPGTGKTLLAEQVAESQGARLItwHVKsttkaqqglyeydaVSRLRDSQLGdpqvqEVANYIKpgKLWD 102
Cdd:COG0464   188 LPPPRGLLLYGPPGTGKTLLARALAGELGLPLI--EVD--------------LSDLVSKYVG-----ETEKNLR--EVFD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 103 AFTAEDPVVLLIDEIDK--ADIEFPND---------LLLELDRMEFHVyetgetiraqrrpVIIITSNNEKELPDAFLRR 171
Cdd:COG0464   245 KARGLAPCVLFIDEADAlaGKRGEVGDgvgrrvvntLLTEMEELRSDV-------------VVIAATNRPDLLDPALLRR 311

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2515253459 172 CFFHF-IRFPERDTLERIVQVHypdLQGRLVKEALDL 207
Cdd:COG0464   312 FDEIIfFPLPDAEERLEIFRIH---LRKRPLDEDVDL 345
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 23-182 1.60e-09

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 55.37  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  23 IQLGRPLLVKGEPGTGKTLLAEQVAESQGARLItwHVKSTTKAQQGLYEYDAvsrlrdsqlgdpqvqevanyiKPGKLWD 102
Cdd:cd19481    23 LGLPKGILLYGPPGTGKTLLAKALAGELGLPLI--VVKLSSLLSKYVGESEK---------------------NLRKIFE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 103 AFTAEDPVVLLIDEIDKADIEFP------------NDLLLELDRMEfhvyetgetiraQRRPVIII-TSNNEKELPDAFL 169
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDssgesgelrrvlNQLLTELDGVN------------SRSKVLVIaATNRPDLLDPALL 147

                         170
                  ....*....|...
gi 2515253459 170 RRCffhfiRFPER 182
Cdd:cd19481   148 RPG-----RFDEV 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 26-180 3.83e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 54.30  E-value: 3.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459   26 GRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEYDAVSRLRDSQLGDPQVQEVANYIKpgklwDAFt 105
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALA-----LAR- 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2515253459  106 AEDPVVLLIDEIDKADIEFPNDLLLELDRMEFhvyetGETIRAQRRPVIIITSNNEKELPDAFLRRCFFHFIRFP 180
Cdd:smart00382  76 KLKPDVLILDEITSLLDAEQEALLLLLEELRL-----LLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLL 145
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
27-188 4.59e-07

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 49.88  E-value: 4.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  27 RPLLVKGEPGTGKTLLAEQVAESQGARLITwhVKSTTkaqqglyeydavsrLRDSQLGDPQVQevanyIKpgKLWDaFTA 106
Cdd:COG1223    36 RKILFYGPPGTGKTMLAEALAGELKLPLLT--VRLDS--------------LIGSYLGETARN-----LR--KLFD-FAR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 107 EDPVVLLIDEID--KADIEFPND----------LLLELDRMEFHVyetgetiraqrrpVIIITSNNEKELPDAFLRRcFF 174
Cdd:COG1223    92 RAPCVIFFDEFDaiAKDRGDQNDvgevkrvvnaLLQELDGLPSGS-------------VVIAATNHPELLDSALWRR-FD 157

                         170
                  ....*....|....
gi 2515253459 175 HFIRFPERDTLERI 188
Cdd:COG1223   158 EVIEFPLPDKEERK 171
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 30-200 2.99e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 43.34  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  30 LVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQqglyEYDAVSRLRDSQLGDPQVQEVanyikpGKLWDAFTAEDP 109
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELLFGDERALIRIDMSEYM----EEHSVSRLIGAPPGYVGYEEG------GQLTEAVRRKPY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459 110 VVLLIDEIDKADIEFPNDLLleldrmefHVYETGETIRAQRRPV------IIITSN-NEKELPDAflRRCFFHFIRFPER 182
Cdd:pfam07724  77 SIVLIDEIEKAHPGVQNDLL--------QILEGGTLTDKQGRTVdfkntlFIMTGNfGSEKISDA--SRLGDSPDYELLK 146

                         170
                  ....*....|....*....
gi 2515253459 183 DTLERIVQVHY-PDLQGRL 200
Cdd:pfam07724 147 EEVMDLLKKGFiPEFLGRL 165
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 29-171 9.60e-05

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 42.03  E-value: 9.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  29 LLVKGEPGTGKTLLAEQVAESQGARLITWHvksttkaqqglyeydaVSRLRDSQLGDPQVQEVANYIKPGKLwdaftaeD 108
Cdd:cd19520    38 VLLYGPPGCGKTMLAKATAKEAGARFINLQ----------------VSSLTDKWYGESQKLVAAVFSLASKL-------Q 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2515253459 109 PVVLLIDEIDK-ADIEFPNDllLELDRM---EFHVYETGETIRAQRRPVIIITSNNEKELPDAFLRR 171
Cdd:cd19520    95 PSIIFIDEIDSfLRQRSSTD--HEATAMmkaEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159
ycf46 CHL00195
Ycf46; Provisional
 18-192 1.84e-04

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 42.70  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  18 AVNAAIQLGRPLLVKGEPGTGKTLLAEQVAESQGARLITWHVKSTTKAQQGLYEydavSRLRdsqlgdpQVQEVANYIKP 97
Cdd:CHL00195  251 ASNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESE----SRMR-------QMIRIAEALSP 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  98 GKLWdaftaedpvvllIDEIDKA--DIEFPNDllleldrmefhvyeTGETIRA----------QRRPVIII-TSNNEKEL 164
Cdd:CHL00195  320 CILW------------IDEIDKAfsNSESKGD--------------SGTTNRVlatfitwlseKKSPVFVVaTANNIDLL 373

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2515253459 165 PDAFLRRCFFH---FIRFPERDTLERIVQVH 192
Cdd:CHL00195  374 PLEILRKGRFDeifFLDLPSLEEREKIFKIH 404
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
14-135 8.27e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 40.22  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  14 ELSLAVNAAIQLGRP--LLVKGEPGTGKTLLA-------EQVAESQGARLITWHV---KSTTkaqqglyEYDAVSRLRDS 81
Cdd:COG1474    37 ELASALRPALRGERPsnVLIYGPTGTGKTAVAkyvleelEEEAEERGVDVRVVYVncrQAST-------RYRVLSRILEE 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2515253459  82 QLGDPQV-------QEVANyikpgKLWDAFTAED-PVVLLIDEIDKADIEFPNDLLLELDRM 135
Cdd:COG1474   110 LGSGEDIpstglstDELFD-----RLYEALDERDgVLVVVLDEIDYLVDDEGDDLLYQLLRA 166
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 27-120 9.36e-04

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 39.20  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  27 RPLLVKGEPGTGKTLLAEQVAESQGARLITW--------HVKSTTKAQQGLY--------------EYDAVSRLRDSQLG 84
Cdd:cd19503    35 RGVLLHGPPGTGKTLLARAVANEAGANFLSIsgpsivskYLGESEKNLREIFeearshapsiifidEIDALAPKREEDQR 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2515253459  85 DPQVQEVANYIkpgKLWDAFTAEDPVVLL-----IDEIDKA 120
Cdd:cd19503   115 EVERRVVAQLL---TLMDGMSSRGKVVVIaatnrPDAIDPA 152
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 14-138 3.32e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 38.38  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  14 ELSLAVNAAIQLGRPL--LVKGEPGTGKTLLA-------EQVAESQGARLITWHVksttKAQQGLYEYDAVSRLRDS-QL 83
Cdd:TIGR02928  26 ELAKALRPILRGSRPSnvFIYGKTGTGKTAVTkyvmkelEEAAEDRDVRVVTVYV----NCQILDTLYQVLVELANQlRG 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2515253459  84 GDPQV-------QEVANyikpgKLWDAFTAEDPVVLLI-DEIDKADIEfPNDLLLELDRMEFH 138
Cdd:TIGR02928 102 SGEEVpttglstSEVFR-----RLYKELNERGDSLIIVlDEIDYLVGD-DDDLLYQLSRARSN 158
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 18-171 3.73e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 37.54  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  18 AVNAAIQ-----LGRP------LLVKGEPGTGKTLLAEQVAE---SQGARLITwhvksttkAQQGLY-EYDAVSRLRDSQ 82
Cdd:cd19499    22 AVSDAIRraragLSDPnrpigsFLFLGPTGVGKTELAKALAEllfGDEDNLIR--------IDMSEYmEKHSVSRLIGAP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2515253459  83 LGdpqvqeVANYIKPGKLWDAFTAEDPVVLLIDEIDKADIEFPNdLLLEldrmefhVYETGETIRAQRRPV------III 156
Cdd:cd19499    94 PG------YVGYTEGGQLTEAVRRKPYSVVLLDEIEKAHPDVQN-LLLQ-------VLDDGRLTDSHGRTVdfkntiIIM 159

                         170
                  ....*....|....*
gi 2515253459 157 TSNNekeLPDAFLRR 171
Cdd:cd19499   160 TSNH---FRPEFLNR 171
PRK09302 PRK09302
circadian clock protein KaiC; Reviewed
 25-45 9.80e-03

circadian clock protein KaiC; Reviewed


Pssm-ID: 236461 [Multi-domain]  Cd Length: 509  Bit Score: 37.17  E-value: 9.80e-03
                          10        20
                  ....*....|....*....|.
gi 2515253459  25 LGRPLLVKGEPGTGKTLLAEQ 45
Cdd:PRK09302   30 KGRPTLVSGTAGTGKTLFALQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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