|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
4-509 |
0e+00 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 545.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 4 LGALAKVGSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKETRSKEATEAF 83
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 84 IRHVAGMLSFVLVIVTTLGILAAPWVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFT 163
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF--DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 164 PTFLNISFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVA 243
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLGVSVS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 244 QISLVINTIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAV 323
Cdd:COG0728 239 QINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 324 GLAVLSFPLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFIS 403
Cdd:COG0728 319 GLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 404 SLKHVGLSLAIGLGACINAGLLFYLLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFeWVHVGGLRKAGQLC 483
Cdd:COG0728 399 PLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGD-WLGGGLLGRLLALA 477
|
490 500
....*....|....*....|....*.
gi 2519490089 484 ILIAIGGGLYFVSLAALGFRPRDFKR 509
Cdd:COG0728 478 LLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-432 |
1.09e-165 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 475.40 E-value: 1.09e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 11 GSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKETRSKEATEAFIRHVAGM 90
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 91 LSFVLVIVTTLGILAAPWVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNIS 170
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF--SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 171 FIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVAQISLVIN 250
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 251 TIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSF 330
Cdd:cd13123 239 TILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 331 PLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGL 410
Cdd:cd13123 319 PIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGL 398
|
410 420
....*....|....*....|..
gi 2519490089 411 SLAIGLGACINAGLLFYLLRKH 432
Cdd:cd13123 399 ALATSLSAWVNALLLLVLLRRR 420
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
2-502 |
7.17e-134 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 397.46 E-value: 7.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 2 NLLGALAKVGSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKEtRSKEATE 81
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKK-KEKEARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 82 AFIRHVAGMLSFVLVIVTTLGILAAPWVIWASAPGFAKDADKfqLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPA 161
Cdd:TIGR01695 80 AFANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 162 FTPTFLNISFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVS 241
Cdd:TIGR01695 158 FSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLPTTLGSS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 242 VAQISLVINTIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPA 321
Cdd:TIGR01695 238 ASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 322 AVGLAVLSFPLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAF 401
Cdd:TIGR01695 318 SFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 402 ISSLKHVGLSLAIGLGACINAGLLFYLLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFEWVHVGGLRkagq 481
Cdd:TIGR01695 398 IFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIVSVSLGGVLVKNLLG---- 473
|
490 500
....*....|....*....|.
gi 2519490089 482 LCILIAIGGGLYFVSLAALGF 502
Cdd:TIGR01695 474 LLAIGLIGLLVYFLGLALLKI 494
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
28-471 |
1.41e-131 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 389.73 E-value: 1.41e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 28 IARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKEtRSKEATEAFIRHVAGMLSFVLVIVTTLGILAAP 107
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKA-QDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 108 WVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNISFIVFSLYFIPYFDPPVT 187
Cdd:pfam03023 80 WLIRLLAPGF--DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 188 ALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVAQISLVINTIFASYLQSGSVSWMYY 267
Cdd:pfam03023 158 ALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 268 ADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSFPLVATLFMYREFTLFDA 347
Cdd:pfam03023 238 ADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 348 QMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGLSLAIGLGACINAGLLFY 427
Cdd:pfam03023 318 TATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYY 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2519490089 428 LLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFEWV 471
Cdd:pfam03023 398 ILRKRLGGFDLRGIKTFLASLVVPTALMAGVILLLSSLTQGPWV 441
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
4-509 |
0e+00 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 545.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 4 LGALAKVGSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKETRSKEATEAF 83
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 84 IRHVAGMLSFVLVIVTTLGILAAPWVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFT 163
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF--DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 164 PTFLNISFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVA 243
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLGVSVS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 244 QISLVINTIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAV 323
Cdd:COG0728 239 QINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 324 GLAVLSFPLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFIS 403
Cdd:COG0728 319 GLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 404 SLKHVGLSLAIGLGACINAGLLFYLLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFeWVHVGGLRKAGQLC 483
Cdd:COG0728 399 PLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGD-WLGGGLLGRLLALA 477
|
490 500
....*....|....*....|....*.
gi 2519490089 484 ILIAIGGGLYFVSLAALGFRPRDFKR 509
Cdd:COG0728 478 LLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-432 |
1.09e-165 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 475.40 E-value: 1.09e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 11 GSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKETRSKEATEAFIRHVAGM 90
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 91 LSFVLVIVTTLGILAAPWVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNIS 170
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF--SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 171 FIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVAQISLVIN 250
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 251 TIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSF 330
Cdd:cd13123 239 TILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 331 PLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGL 410
Cdd:cd13123 319 PIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGL 398
|
410 420
....*....|....*....|..
gi 2519490089 411 SLAIGLGACINAGLLFYLLRKH 432
Cdd:cd13123 399 ALATSLSAWVNALLLLVLLRRR 420
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
2-502 |
7.17e-134 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 397.46 E-value: 7.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 2 NLLGALAKVGSLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKEtRSKEATE 81
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKK-KEKEARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 82 AFIRHVAGMLSFVLVIVTTLGILAAPWVIWASAPGFAKDADKfqLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPA 161
Cdd:TIGR01695 80 AFANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 162 FTPTFLNISFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVS 241
Cdd:TIGR01695 158 FSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLPTTLGSS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 242 VAQISLVINTIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPA 321
Cdd:TIGR01695 238 ASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 322 AVGLAVLSFPLVATLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAF 401
Cdd:TIGR01695 318 SFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 402 ISSLKHVGLSLAIGLGACINAGLLFYLLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFEWVHVGGLRkagq 481
Cdd:TIGR01695 398 IFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIVSVSLGGVLVKNLLG---- 473
|
490 500
....*....|....*....|.
gi 2519490089 482 LCILIAIGGGLYFVSLAALGF 502
Cdd:TIGR01695 474 LLAIGLIGLLVYFLGLALLKI 494
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
28-471 |
1.41e-131 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 389.73 E-value: 1.41e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 28 IARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVPILAEYKEtRSKEATEAFIRHVAGMLSFVLVIVTTLGILAAP 107
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKA-QDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 108 WVIWASAPGFakDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNISFIVFSLYFIPYFDPPVT 187
Cdd:pfam03023 80 WLIRLLAPGF--DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 188 ALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVAQISLVINTIFASYLQSGSVSWMYY 267
Cdd:pfam03023 158 ALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 268 ADRLMELPSGVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSFPLVATLFMYREFTLFDA 347
Cdd:pfam03023 238 ADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 348 QMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGLSLAIGLGACINAGLLFY 427
Cdd:pfam03023 318 TATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYY 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2519490089 428 LLRKHGIYRPGKGWGSFLGKMLLSLVVMGSGLWAAQTYLPFEWV 471
Cdd:pfam03023 398 ILRKRLGGFDLRGIKTFLASLVVPTALMAGVILLLSSLTQGPWV 441
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
95-509 |
6.97e-20 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 92.53 E-value: 6.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 95 LVIVTTLGILAAPwVIWASAPGFAKDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPT---FLNISF 171
Cdd:COG5841 89 LLLLLILGLVFFL-LLFFGAPFIARLLLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVieqIVRVIF 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 172 IVFSLYFIPYFDPP--VTALAWAVFVGGILQLGF-------QLPWLAKLGFLKLPKLNFQDRA-VNRVMKQMAPAILGVS 241
Cdd:COG5841 168 ILLLAYLLLPYGLEyaAAGATFGAVIGALAGLLVllyyyrkRKKKLKRLLEKSKTKSKESSKDiLKELLRIAIPITLSSL 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 242 VAQISLVINTI-FASYLQSGSVSW-----MY-----YADRLMELPSgVLGAALGTILLPTLSKHAANQNTEQFSGLLDWG 310
Cdd:COG5841 248 VLPLFQLIDSFtVPRRLQAAGLSAseatsLYgilsgMAQPLVNLPT-VLATALATSLVPAISEAFAKKDRKLVRRRINQA 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 311 LRLCMLLTLPAAVGLAVLSFPLVATLFMYREFTlfdaqmtqHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFT 390
Cdd:COG5841 327 LRLTLLIGLPAAVGLAVLAEPINTLLFGNPEGG--------GILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIG 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 391 LICTQLMNLAFISSLKHVGLSLAIGLGACINAGLLFYLLRKHGIYRPgkGWGSFLGKMLLSLVVMGSGLWAAQTYLPFeW 470
Cdd:COG5841 399 LLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKL--DLRRRLLKPLLASLIMGIVVLLLYRLLSL-F 475
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 2519490089 471 VHVGGLRKAGQLCILIAIGGGLYFVSLAALG-FRPRDFKR 509
Cdd:COG5841 476 LPESRLGALLATLIAVLVGAIVYLLLLLKLGlITKEELRR 515
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
69-432 |
1.23e-14 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 75.97 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 69 AEYKETRSKEATEAFIRHVAGMLSFVLVIVTTLGILAAPWViwasAPGFAKDADkfqlSIDLLRITFPYILLISLSSFVG 148
Cdd:cd13124 60 AEYNALGDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFL----AQLLLGDPR----LAPVIRALAPAILIVPLLSVLR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 149 SILNSYHKFSIPA---FTPTFLNISFI-VFSLYFIPYFDPPVTALAWAVF---VGGILQLGFQLPWLAKLGFLKLPKLNF 221
Cdd:cd13124 132 GYFQGLQNMTPTAvsqVIEQIVRVIVIlVLAYLLLPVGGGLYYAAAGATFgavIGALAGLLVLLYYYRKKRRELKRLLRK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 222 QDRAV-------NRVMKQMAPAILGVSVAQISLVINTIF-------ASYLQSGSVSWM-YYADR---LMELPSgVLGAAL 283
Cdd:cd13124 212 SPRSKistkeilKELLSYAIPITLSSLILPLLQLIDSFTvprrlqaAGLSESEATALYgILTGRaqpLVQLPT-VIATAL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 284 GTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSFPLVATLFMYREFTlfdaqmtqHALIAYSFGLIG 363
Cdd:cd13124 291 STSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGG--------LILQILAPSILF 362
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2519490089 364 LIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGLSLAIGLGACINAGLLFYLLRKH 432
Cdd:cd13124 363 LSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
91-430 |
5.01e-12 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 67.57 E-value: 5.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 91 LSFVLVIVTTLGILAAPwVIWASAPGFAKDAdkfQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNIS 170
Cdd:cd13128 76 ISTSLVLKLILGILALL-LLFLFAFLIAFYD---PELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 171 FIVFSLYFIpYFDPPVTALAWAVFVGGILQLGFQLpWLAKLGFLKLPKLNFQDRAVNRVMKQMAPAILGVSVAQISLVIN 250
Cdd:cd13128 152 SLILALILV-LLGGGLIGFALAYLIASVLSAILLL-YIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRID 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 251 TIFASYLQS-GSVSWMYYADRLMELPSGVLgAALGTILLPTLSKHAANqNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLS 329
Cdd:cd13128 230 TIMLGYFLGdAAVGIYNAAYRIAELLLFIP-SAISTALFPRISELYKN-DKDELKKLLKKSFKYLFLISLPIAIGLFLFA 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 330 FPLVatLFMYREFTLFDAQMTQHALIAYSFGLIGLIMIKVLApgfyARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVG 409
Cdd:cd13128 308 EPII--TLLFGEEYLPAALVLQILAWGFLFIFLNGIFGSILQ----AIGKQKLTLKILLIGALLNVILNLLLIPKYGIIG 381
|
330 340
....*....|....*....|.
gi 2519490089 410 LSLAIGLGACINAGLLFYLLR 430
Cdd:cd13128 382 AAIATLISEFIIFILLLYLLK 402
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
1-426 |
1.61e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 47.25 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 1 MNLLGALAKVGSLTMVSRILGFVRDTVIARAFGAGMAtDAFFVAFKLPNLLrRVFAEGAFAQAFVPILAEYKEtrskEAT 80
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEY-GLFALALSIVALL-SVLADLGLSTALVRFIAEYRE----EEL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 81 EAFIRHVAGMLSFVLVIVTTLGILAAPWVIWASapgfakdadKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIP 160
Cdd:COG2244 76 RRLLSTALLLRLLLSLLLALLLLLLAPFIAALL---------GEPELALLLLLLALALLLSALSAVLLALLRGLERFKLL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 161 AFTPTFLNISFIVFSLYFIpYFDPPVTALawavfvggilqlgfqlpwlaklgflklpklnfqdravnrVMKQMAPAILGV 240
Cdd:COG2244 147 ALINILSSLLSLLLALLLA-LLGLGLWGL---------------------------------------VLKYSLPLLLSG 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 241 SVAQISLVINTIF-ASYLQSGSVSWMYYADRLMELPSgVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTL 319
Cdd:COG2244 187 LLGLLLTNLDRLLlGALLGPAAVGIYSAAYRLASLLL-LLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 320 PAAVGLAVLSFPLVATLFMYreftlfDAQMTQHALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNL 399
Cdd:COG2244 266 PLALGLALLAPPLLSLLFGP------EYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNL 339
|
410 420
....*....|....*....|....*..
gi 2519490089 400 AFISSLKHVGLSLAIGLGACINAGLLF 426
Cdd:COG2244 340 LLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
13-430 |
3.45e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 46.16 E-value: 3.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 13 LTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLRRVFAEGAFAQAFVpilAEYKETRSKEATEAFIRHVAGMLS 92
Cdd:cd12082 6 LSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALI---SQAIGAGDEEKARRVLVQSIVLAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 93 FVLVIVTTLGILAAPWVIWAsapgFAKDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFLNISFI 172
Cdd:cd12082 83 LLGLLLAALLLFFSPLILSL----LGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 173 VFSLYFIPYFDPP---VTALAWAVFVGGILQLGFQLPWLAKLGFLKLPKLNFQDRAVN---RVMKQMAPAILGVSVAQIS 246
Cdd:cd12082 159 LLDPLLIFGLGPPelgIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLEllrRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 247 LVINTIFASYLQSGSVSWMY-YADRLMELPSgVLGAALGTILLPTLSKHAANQNTEQFSGLLDWGLRLCMLLTLPAAVGL 325
Cdd:cd12082 239 LLIIVAIVAAFGGAAALAAYtVAFRIASLAF-MPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 326 AVLSFPLVATLFMYREFTLFDAQMTQhaLIAYSFGLIGLIMikVLAPGFYARQNIKTPVKIAIFTLICTQLMnLAFISSL 405
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLR--ILAIYYLFVGIGY--VLQAGFQAAGRTLKSLIVSLLSYWVVRLP-LAYVLAY 392
|
410 420
....*....|....*....|....*...
gi 2519490089 406 KHVGLS---LAIGLGACINAGLLFYLLR 430
Cdd:cd12082 393 LGLGLYgiwLALVISLILAALVLLLFFR 420
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
14-337 |
1.30e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 44.40 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 14 TMVSRILGFVRDTVIAR-----AFG-AGMATdaFFVAFKlpnllrRVFAEGAFAQAFVpilaeyketRSKEATEAFIRHV 87
Cdd:cd13127 12 QVVVQLLQFVVTIILARlltpeDFGlVAMAT--VFIAFA------QLFSDLGLSSALI---------QRKDLTEEDLSTV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 88 AGMLSFVLVIVTTLGILAAPWVIWasapgFAKDadkfQLSIDLLRITFPYILLISLSSFVGSILNSYHKFSIPAFTPTFL 167
Cdd:cd13127 75 FWLNLLLGLLLYLLLFLLAPLIAA-----FYNE----PELIPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELIS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 168 NISFIVFSLYFIpYFDPPVTALAWAVFVGGILQLGFQLpWLAKlgflKLPKLNFQDRAVNRV----MKQMAPAILGVSVA 243
Cdd:cd13127 146 TLVSGVVAIVLA-LLGFGVWALVAQQLVGALVSTVLLW-ILSR----WRPRLSFSLASLKELlsfgSKLLGSNLLNYFSR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 244 QISlviNTIFASYLQSGSVSWMYYADRLMELPSGVLGAALGTILLPTLSKHAANQntEQFSGLLDWGLRLCMLLTLPAAV 323
Cdd:cd13127 220 NLD---NLIIGKFLGAAALGYYSRAYRLALLPVQNITGPITRVLFPALSRLQDDP--ERLRRAYLKALRLLALITFPLMV 294
|
330
....*....|....
gi 2519490089 324 GLAVLSFPLVATLF 337
Cdd:cd13127 295 GLALLAEPLVLLLL 308
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
353-501 |
3.97e-04 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 40.63 E-value: 3.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 353 ALIAYSFGLIGLIMIKVLAPGFYARQNIKTPVKIAIFTLICTQLMNLAFISSLKHVGLSLAIGLGACINAGLLFYLLRKH 432
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2519490089 433 GIYRPGKGWgsfLGKMLLSLVVMGSGLWAaqtylpFEWVHVGGLRKAGQLCILIAIGGGLYFVSLAALG 501
Cdd:pfam14667 81 LGLRLLLRR---LLKPLLAALVMGIVVYL------LLLLLGLLLGLALALLLAVLVGALVYLLLLLLLK 140
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
11-337 |
1.11e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 41.37 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 11 GSLTMVSRILGFVRDTVIARAFG-AGMATDAFFVAFKLpnlLRRVFAEGAFAQAFVPILAEYKEtrSKEATEAFIRHVAG 89
Cdd:cd13125 7 GISTLIKILAGLIINKVVAVYLGpSGVALLGQLQNFVT---ILQTIAGGGINNGVVKYTAEYKD--DEEKLARVWSTAFR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 90 MLSFVLVIVTTLGILAAPWViwasAPGFAKDADkFQLSIDLLRITFPyilLISLSSFVGSILNSYHKFSIPAFTPTFLNI 169
Cdd:cd13125 82 ITLILSILGGLLLLLFSKPL----SSLLFGDID-YSWVFILLGLALP---LFALNNLLLAILNGLKEIKRYALINIISSL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 170 SFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLpwLAKLGFLKLPKLNFqdRAVNRVMKQMAPAILGVSVAQISLVI 249
Cdd:cd13125 154 IGLLVSVLLVYFYGLKGALLALVLNQSLIFLVTLIY--SRKQPWFKLKYLWG--RLDKDIIKKLLKFSLMALVSALSLPL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 250 NTIFASYLQSGSVSWM---YY--ADRLMELPSGVLGAALGTILLPTLSkhaANQNTEQFSGLLDWGLRLCMLLTLPAAVG 324
Cdd:cd13125 230 SQIIVRNILIRQLGWEaagYWqaVWKISDVYLGFITTALSTYYLPRLS---AIKDNKELKREVNKQLKVILPLVAIGALL 306
|
330
....*....|...
gi 2519490089 325 LAVLSFPLVATLF 337
Cdd:cd13125 307 IYLLRDLIIQILF 319
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
268-337 |
3.44e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 39.50 E-value: 3.44e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 268 ADRLMELPSGVLGAALGTILLPTLSKhaANQNTEQFSGLLDWGLRLCMLLTLPAAVGLAVLSFPLVATLF 337
Cdd:pfam13440 217 AYRLALLPTANITSVITKVLFPALSR--IQDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLL 284
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
2-208 |
7.16e-03 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 38.84 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 2 NLLGALAKVG---SLTMVSRILGFVRDTVIARAFGAGMATDAFFVAFKLPNLLrrVFAEGAFAQAFVPILAEYKETRSKE 78
Cdd:cd12082 216 ELLRRLLRIGlpsAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLA--FMPALGLAQAALPVVGQNLGAGNFD 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519490089 79 ATEAFIRHVAGMLSFVLVIVTTLGILAAPWVIWAsapgFAKDADKFQLSIDLLRITFPYILLISLSSFVGSILNSYHKFS 158
Cdd:cd12082 294 RARRITWVALLIGLLIGAVLGLLILLFPEPILSL----FTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTL 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2519490089 159 IPAFTPTFLNISFIVFSLYFIPYFDPPVTALAWAVFVGGILQLGFQLPWL 208
Cdd:cd12082 370 KSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| |
