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Conserved domains on  [gi|2524693297|ref|WP_286715899|]
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MULTISPECIES: isoprenylcysteine carboxylmethyltransferase family protein [unclassified Marinobacter]

Protein Classification

methyltransferase family protein( domain architecture ID 10005179)

methyltransferase family protein such as methanethiol S-methyltransferase that catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS)

EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 101-209 1.82e-31

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 111.02  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 101 FHLLSTVFIGGGFYLIAAGWRTLYAAQKERKLATSGLYSYVRHPQYVGFVLIMFGFLLQWPTLITLAMFPVLLWMYARLS 180
Cdd:COG2020     5 LILLGLLLRLWAVLTLGRSWTTLVPPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLLLYVLRI 84

                          90       100
                  ....*....|....*....|....*....
gi 2524693297 181 ISEEREAEKTFGEAWRHYADNTPRFLPRL 209
Cdd:COG2020    85 RREERRLRARFGEEYRAYAARVPRLIPRL 113
 
Name Accession Description Interval E-value
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 101-209 1.82e-31

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 111.02  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 101 FHLLSTVFIGGGFYLIAAGWRTLYAAQKERKLATSGLYSYVRHPQYVGFVLIMFGFLLQWPTLITLAMFPVLLWMYARLS 180
Cdd:COG2020     5 LILLGLLLRLWAVLTLGRSWTTLVPPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLLLYVLRI 84

                          90       100
                  ....*....|....*....|....*....
gi 2524693297 181 ISEEREAEKTFGEAWRHYADNTPRFLPRL 209
Cdd:COG2020    85 RREERRLRARFGEEYRAYAARVPRLIPRL 113
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 100-194 1.31e-07

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 48.33  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 100 PFHLLSTVFIGGGFYLIAAGWRTL---------YAAQKERKLATSGLYSYVRHPQYVGFVLIMFG-FLLQWPTLITLAMF 169
Cdd:pfam04191   1 LRLILGLLLIALGLWLVLSSYRALgifgtfygdFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGlALITGSPAGLLLAL 80

                          90       100
                  ....*....|....*....|....*
gi 2524693297 170 PVLLWMYARLSISEEREAEKTFGEA 194
Cdd:pfam04191  81 LVLLVYFIALKFVEEPHMAKIYGKR 105
 
Name Accession Description Interval E-value
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 101-209 1.82e-31

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 111.02  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 101 FHLLSTVFIGGGFYLIAAGWRTLYAAQKERKLATSGLYSYVRHPQYVGFVLIMFGFLLQWPTLITLAMFPVLLWMYARLS 180
Cdd:COG2020     5 LILLGLLLRLWAVLTLGRSWTTLVPPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLLLYVLRI 84

                          90       100
                  ....*....|....*....|....*....
gi 2524693297 181 ISEEREAEKTFGEAWRHYADNTPRFLPRL 209
Cdd:COG2020    85 RREERRLRARFGEEYRAYAARVPRLIPRL 113
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 100-194 1.31e-07

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 48.33  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 100 PFHLLSTVFIGGGFYLIAAGWRTL---------YAAQKERKLATSGLYSYVRHPQYVGFVLIMFG-FLLQWPTLITLAMF 169
Cdd:pfam04191   1 LRLILGLLLIALGLWLVLSSYRALgifgtfygdFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGlALITGSPAGLLLAL 80

                          90       100
                  ....*....|....*....|....*
gi 2524693297 170 PVLLWMYARLSISEEREAEKTFGEA 194
Cdd:pfam04191  81 LVLLVYFIALKFVEEPHMAKIYGKR 105
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 120-187 1.22e-05

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 42.34  E-value: 1.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524693297 120 WRTLYAAQKERKLATSGLYSYVRHPQYVGFVLIMFG--FLLQWPTLITLAMFPVLLWMYARLSISEEREA 187
Cdd:pfam04140  23 WNHRVAILPDHRLVTSGPYRYLRHPNYFGWFIWEIAtqPLLCNAWYTALVFYALNAWLLFSVRIRQEEKA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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