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Conserved domains on  [gi|2524904597|ref|WP_286855292|]
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hypothetical protein, partial [Marinobacter sp. UBA4489]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lldD super family cl29522
L-lactate dehydrogenase; Provisional
 1-29 8.70e-17

L-lactate dehydrogenase; Provisional


The actual alignment was detected with superfamily member PRK11197:

Pssm-ID: 183033  Cd Length: 381  Bit Score: 70.05  E-value: 8.70e-17
                          10        20
                  ....*....|....*....|....*....
gi 2524904597   1 MIISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:PRK11197    1 MIISAASDYRAAAQRRLPPFLFHYIDGGA 29
 
Name Accession Description Interval E-value
lldD PRK11197
L-lactate dehydrogenase; Provisional
 1-29 8.70e-17

L-lactate dehydrogenase; Provisional


Pssm-ID: 183033  Cd Length: 381  Bit Score: 70.05  E-value: 8.70e-17
                          10        20
                  ....*....|....*....|....*....
gi 2524904597   1 MIISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:PRK11197    1 MIISAASDYRAAAQRRLPPFLFHYIDGGA 29
L_lactate_LldD NF033901
FMN-dependent L-lactate dehydrogenase LldD; LldD is an FMN-dependent L-lactate dehydrogenase. ...
 1-29 2.32e-14

FMN-dependent L-lactate dehydrogenase LldD; LldD is an FMN-dependent L-lactate dehydrogenase. It occurs in E. coli, Salmonella, and as one of two L-lactate dehydrogenases in Pseudomonas aeruginosa. It is unrelated to the NAD-dependent enzyme.


Pssm-ID: 411463  Cd Length: 377  Bit Score: 63.30  E-value: 2.32e-14
                          10        20
                  ....*....|....*....|....*....
gi 2524904597   1 MIISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:NF033901    1 MIISASTDYRAAAQRKLPPFLFHYIDGGA 29
LldD COG1304
FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl ...
 3-29 1.42e-07

FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase [Energy production and conversion, Lipid transport and metabolism, General function prediction only]; FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440915 [Multi-domain]  Cd Length: 357  Bit Score: 43.97  E-value: 1.42e-07
                          10        20
                  ....*....|....*....|....*..
gi 2524904597   3 ISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:COG1304     4 ILSIEDLRRIARRKLPRFAFDYIDGGA 30
alpha_hydroxyacid_oxid_FMN cd02809
Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in ...
 7-29 4.92e-07

Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO). In green plants, glycolate oxidase is one of the key enzymes in photorespiration where it oxidizes glycolate to glyoxylate. LMO catalyzes the oxidation of L-lactate to acetate and carbon dioxide. MDH oxidizes (S)-mandelate to phenylglyoxalate. It is an enzyme in the mandelate pathway that occurs in several strains of Pseudomonas which converts (R)-mandelate to benzoate.


Pssm-ID: 239203 [Multi-domain]  Cd Length: 299  Bit Score: 42.43  E-value: 4.92e-07
                          10        20
                  ....*....|....*....|...
gi 2524904597   7 HDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:cd02809     1 ADLRALARRRLPKAVFDYIDGGA 23
FMN_dh pfam01070
FMN-dependent dehydrogenase;
13-29 2.12e-04

FMN-dependent dehydrogenase;


Pssm-ID: 426029 [Multi-domain]  Cd Length: 350  Bit Score: 34.81  E-value: 2.12e-04
                          10
                  ....*....|....*..
gi 2524904597  13 AKRRLPPFLFHYIDGGA 29
Cdd:pfam01070   1 ARKRLPRFAFDYLDGGA 17
 
Name Accession Description Interval E-value
lldD PRK11197
L-lactate dehydrogenase; Provisional
 1-29 8.70e-17

L-lactate dehydrogenase; Provisional


Pssm-ID: 183033  Cd Length: 381  Bit Score: 70.05  E-value: 8.70e-17
                          10        20
                  ....*....|....*....|....*....
gi 2524904597   1 MIISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:PRK11197    1 MIISAASDYRAAAQRRLPPFLFHYIDGGA 29
L_lactate_LldD NF033901
FMN-dependent L-lactate dehydrogenase LldD; LldD is an FMN-dependent L-lactate dehydrogenase. ...
 1-29 2.32e-14

FMN-dependent L-lactate dehydrogenase LldD; LldD is an FMN-dependent L-lactate dehydrogenase. It occurs in E. coli, Salmonella, and as one of two L-lactate dehydrogenases in Pseudomonas aeruginosa. It is unrelated to the NAD-dependent enzyme.


Pssm-ID: 411463  Cd Length: 377  Bit Score: 63.30  E-value: 2.32e-14
                          10        20
                  ....*....|....*....|....*....
gi 2524904597   1 MIISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:NF033901    1 MIISASTDYRAAAQRKLPPFLFHYIDGGA 29
LldD COG1304
FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl ...
 3-29 1.42e-07

FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase [Energy production and conversion, Lipid transport and metabolism, General function prediction only]; FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440915 [Multi-domain]  Cd Length: 357  Bit Score: 43.97  E-value: 1.42e-07
                          10        20
                  ....*....|....*....|....*..
gi 2524904597   3 ISSTHDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:COG1304     4 ILSIEDLRRIARRKLPRFAFDYIDGGA 30
alpha_hydroxyacid_oxid_FMN cd02809
Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in ...
 7-29 4.92e-07

Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO). In green plants, glycolate oxidase is one of the key enzymes in photorespiration where it oxidizes glycolate to glyoxylate. LMO catalyzes the oxidation of L-lactate to acetate and carbon dioxide. MDH oxidizes (S)-mandelate to phenylglyoxalate. It is an enzyme in the mandelate pathway that occurs in several strains of Pseudomonas which converts (R)-mandelate to benzoate.


Pssm-ID: 239203 [Multi-domain]  Cd Length: 299  Bit Score: 42.43  E-value: 4.92e-07
                          10        20
                  ....*....|....*....|...
gi 2524904597   7 HDYRLAAKRRLPPFLFHYIDGGA 29
Cdd:cd02809     1 ADLRALARRRLPKAVFDYIDGGA 23
MDH_FMN cd04736
Mandelate dehydrogenase (MDH)-like FMN-binding domain. MDH is part of a widespread family of ...
 8-29 3.55e-05

Mandelate dehydrogenase (MDH)-like FMN-binding domain. MDH is part of a widespread family of homologous FMN-dependent a-hydroxy acid oxidizing enzymes that oxidizes (S)-mandelate to phenylglyoxalate. MDH is an enzyme in the mandelate pathway that occurs in several strains of Pseudomonas which converts (R)-mandelate to benzoate. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO).


Pssm-ID: 240087  Cd Length: 361  Bit Score: 37.12  E-value: 3.55e-05
                          10        20
                  ....*....|....*....|..
gi 2524904597   8 DYRLAAKRRLPPFLFHYIDGGA 29
Cdd:cd04736     2 DYRSLAKKRLPRMVFDYLEGGA 23
FMN_dh pfam01070
FMN-dependent dehydrogenase;
13-29 2.12e-04

FMN-dependent dehydrogenase;


Pssm-ID: 426029 [Multi-domain]  Cd Length: 350  Bit Score: 34.81  E-value: 2.12e-04
                          10
                  ....*....|....*..
gi 2524904597  13 AKRRLPPFLFHYIDGGA 29
Cdd:pfam01070   1 ARKRLPRFAFDYLDGGA 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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