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Conserved domains on  [gi|2525148015|ref|WP_287035404|]
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phosphotransferase family protein [Enterococcus sp.]

Protein Classification

phosphotransferase family protein( domain architecture ID 10007008)

phosphotransferase family protein may catalyze the phosphorylation of aminoglycosides and confer aminoglycoside antibiotic resistance; similar to viomycin phosphotransferase, 4-hydroxytryptamine kinase, and hygromycin B phosphotransferase

CATH:  1.10.510.10
EC:  2.7.-.-
Gene Ontology:  GO:0016301|GO:0005524|GO:0016310
PubMed:  16244704
SCOP:  3000066

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-235 1.08e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


:

Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 95.18  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015   7 QAAIEKVYPDLV-IENFEFLGSGFDSDAFLL--NQSYVFKF-PRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESN 82
Cdd:COG3173     9 RALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALGEDG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  83 RKHQLEFVGHEKINGVPLTaDILQSLTTEEKENLNKELAAFFKALHEIKLPEsiEGLEVDKKT---------KAAYEYKV 153
Cdd:COG3173    89 EVIGAPFYVMEWVEGETLE-DALPDLSPAERRALARALGEFLAALHAVDPAA--AGLADGRPEglerqlarwRAQLRRAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 154 IKQAAYPllpksvqlEIDEVYRRILQQDFHYQK--CLIHNDFGASNVYYDQATNQICGLIDFGDVAIYDRDMEFVCLMFD 231
Cdd:COG3173   166 ARTDDLP--------ALRERLAAWLAANLPEWGppVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLLLY 237


                  ....
gi 2525148015 232 YEEG 235
Cdd:COG3173   238 WRLP 241
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-235 1.08e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 95.18  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015   7 QAAIEKVYPDLV-IENFEFLGSGFDSDAFLL--NQSYVFKF-PRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESN 82
Cdd:COG3173     9 RALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALGEDG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  83 RKHQLEFVGHEKINGVPLTaDILQSLTTEEKENLNKELAAFFKALHEIKLPEsiEGLEVDKKT---------KAAYEYKV 153
Cdd:COG3173    89 EVIGAPFYVMEWVEGETLE-DALPDLSPAERRALARALGEFLAALHAVDPAA--AGLADGRPEglerqlarwRAQLRRAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 154 IKQAAYPllpksvqlEIDEVYRRILQQDFHYQK--CLIHNDFGASNVYYDQATNQICGLIDFGDVAIYDRDMEFVCLMFD 231
Cdd:COG3173   166 ARTDDLP--------ALRERLAAWLAANLPEWGppVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLLLY 237


                  ....
gi 2525148015 232 YEEG 235
Cdd:COG3173   238 WRLP 241
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 22-242 6.70e-19

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 83.70  E-value: 6.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  22 FEFLGSGFDSDAFLL---NQSYVFKFPRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESNRKHQLEFVGHEKINGV 98
Cdd:pfam01636   2 LRPISSGASNRTYLVttgDGRYVLRLPPPGRAAEELRRELALLRHLAAAGVPPVPRVLAGCTDAELLGLPFLLMEYLPGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  99 PLTADILQslttEEKENLNKELAAFFKALHEIKLP------ESIEGLEVDKKTKAAYEYKVikqaayPLLPKSVQLEIDE 172
Cdd:pfam01636  82 VLARPLLP----EERGALLEALGRALARLHAVDPAalplagRLARLLELLRQLEAALARLL------AAELLDRLEELEE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2525148015 173 VYRRILQQ--DFHYQKCLIHNDFGASNVYYDqATNQICGLIDFGDVAIYDRDMEFVCLMFDYEEGFNQEFVQ 242
Cdd:pfam01636 152 RLLAALLAllPAELPPVLVHGDLHPGNLLVD-PGGRVSGVIDFEDAGLGDPAYDLAILLNSWGRELGAELLA 222
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 25-234 5.23e-15

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 71.18  E-value: 5.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  25 LGSGFDSDAFLLN--QSYVFKFPRhARAARNLYKEAVVLREIKDQVPLKVPEICFVGESnrkHQLEFVGHEKINGVPLTa 102
Cdd:cd05120     6 IKEGGDNKVYLLGdpREYVLKIGP-PRLKKDLEKEAAMLQLLAGKLSLPVPKVYGFGES---DGWEYLLMERIEGETLS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 103 DILQSLTTEEKENLNKELAAFFKALHEIKLPesieglevdkktkaayeykvikqaaypllpksvqleidevyrrilqqdf 182
Cdd:cd05120    81 EVWPRLSEEEKEKIADQLAEILAALHRIDSS------------------------------------------------- 111

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2525148015 183 hyqkCLIHNDFGASNVYYDQaTNQICGLIDFGDVAIYDRDMEFVCLMFDYEE 234
Cdd:cd05120   112 ----VLTHGDLHPGNILVKP-DGKLSGIIDWEFAGYGPPAFDYAAALRDWTE 158
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-235 1.08e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 95.18  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015   7 QAAIEKVYPDLV-IENFEFLGSGFDSDAFLL--NQSYVFKF-PRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESN 82
Cdd:COG3173     9 RALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALGEDG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  83 RKHQLEFVGHEKINGVPLTaDILQSLTTEEKENLNKELAAFFKALHEIKLPEsiEGLEVDKKT---------KAAYEYKV 153
Cdd:COG3173    89 EVIGAPFYVMEWVEGETLE-DALPDLSPAERRALARALGEFLAALHAVDPAA--AGLADGRPEglerqlarwRAQLRRAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 154 IKQAAYPllpksvqlEIDEVYRRILQQDFHYQK--CLIHNDFGASNVYYDQATNQICGLIDFGDVAIYDRDMEFVCLMFD 231
Cdd:COG3173   166 ARTDDLP--------ALRERLAAWLAANLPEWGppVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLLLY 237


                  ....
gi 2525148015 232 YEEG 235
Cdd:COG3173   238 WRLP 241
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 22-242 6.70e-19

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 83.70  E-value: 6.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  22 FEFLGSGFDSDAFLL---NQSYVFKFPRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESNRKHQLEFVGHEKINGV 98
Cdd:pfam01636   2 LRPISSGASNRTYLVttgDGRYVLRLPPPGRAAEELRRELALLRHLAAAGVPPVPRVLAGCTDAELLGLPFLLMEYLPGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  99 PLTADILQslttEEKENLNKELAAFFKALHEIKLP------ESIEGLEVDKKTKAAYEYKVikqaayPLLPKSVQLEIDE 172
Cdd:pfam01636  82 VLARPLLP----EERGALLEALGRALARLHAVDPAalplagRLARLLELLRQLEAALARLL------AAELLDRLEELEE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2525148015 173 VYRRILQQ--DFHYQKCLIHNDFGASNVYYDqATNQICGLIDFGDVAIYDRDMEFVCLMFDYEEGFNQEFVQ 242
Cdd:pfam01636 152 RLLAALLAllPAELPPVLVHGDLHPGNLLVD-PGGRVSGVIDFEDAGLGDPAYDLAILLNSWGRELGAELLA 222
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 25-234 5.23e-15

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 71.18  E-value: 5.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  25 LGSGFDSDAFLLN--QSYVFKFPRhARAARNLYKEAVVLREIKDQVPLKVPEICFVGESnrkHQLEFVGHEKINGVPLTa 102
Cdd:cd05120     6 IKEGGDNKVYLLGdpREYVLKIGP-PRLKKDLEKEAAMLQLLAGKLSLPVPKVYGFGES---DGWEYLLMERIEGETLS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 103 DILQSLTTEEKENLNKELAAFFKALHEIKLPesieglevdkktkaayeykvikqaaypllpksvqleidevyrrilqqdf 182
Cdd:cd05120    81 EVWPRLSEEEKEKIADQLAEILAALHRIDSS------------------------------------------------- 111

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2525148015 183 hyqkCLIHNDFGASNVYYDQaTNQICGLIDFGDVAIYDRDMEFVCLMFDYEE 234
Cdd:cd05120   112 ----VLTHGDLHPGNILVKP-DGKLSGIIDWEFAGYGPPAFDYAAALRDWTE 158
APH_ChoK_like_1 cd05155
Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and ...
 27-220 3.58e-07

Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase; This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270704 [Multi-domain]  Cd Length: 234  Bit Score: 50.31  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  27 SGFDSDAFLLNQSYVFKFPRHARAARNLYKEAVVLREIKDQVPLKVPEICFVGESNRKHQLEFVGHEKINGVPLTADILq 106
Cdd:cd05155     8 SGWDNATFRLGDDLAVRLPRRAWAAELLEKEQRWLPRLAPRLPLPVPVPLALGKPGAGYPWPWSVYRWLEGETAADAPL- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 107 slttEEKENLNKELAAFFKALHEIKLPE-SIEGLEVDKKTKAAYEYKVIKQAAyPLLPKSVQLEIDEVYRRILQQDFHYQ 185
Cdd:cd05155    87 ----ADPAAAAEDLARFLAALHAIDPAGpPNPGRGNPLRGRDLAVRDAEEALA-ALAGLLDVAAARALWERALAAPAWAG 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2525148015 186 K-CLIHNDFGASNVYYDQatNQICGLIDFGDVAIYD 220
Cdd:cd05155   162 PpVWLHGDLHPGNLLVRD--GRLSAVIDFGDLGVGD 195
MPH2' cd05152
Macrolide 2'-Phosphotransferase; MPH2' catalyzes the transfer of the gamma-phosphoryl group ...
 16-247 4.78e-06

Macrolide 2'-Phosphotransferase; MPH2' catalyzes the transfer of the gamma-phosphoryl group from ATP to the 2'-hydroxyl of macrolide antibiotics such as erythromycin, clarithromycin, and azithromycin, among others. Macrolides penetrate the bacterial cell and bind to ribosomes, where it interrupts protein elongation, leading ultimately to the demise of the bacterium. Phosphorylation of macrolides leads to their inactivation. Based on substrate specificity and amino acid sequence, MPH2' is divided into types I and II, encoded by mphA and mphB genes, respectively. MPH2'I inactivates 14-membered ring macrolides while MPH2'II inactivates both 14- and 16-membered ring macrolides. Enzymatic inactivation of macrolides has been reported as a mechanism for bacterial resistance in clinical samples. MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270701 [Multi-domain]  Cd Length: 276  Bit Score: 47.24  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  16 DLVIENFEFLGSGFDSD-AFLL---NQSYVFKFPRHARAARNLYKEAVVLREIKDQVPLKVPEIcfvgesnRKHQLEFVG 91
Cdd:cd05152    10 DLKPATLRLNESGLDFQvAFARdteGRRWVLRIPRRPDVSERLEAEKKVLDLVTPHLPFAVPDW-------RIHTPELIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015  92 HEKINGVPLTADILQSLTTE-------EKENLNKELAAFFKALHEIKLPESIE-GLEVdkktKAAYEYKvikqaaypllp 163
Cdd:cd05152    83 YPLLPGVPAATIDPEIQNYVwnwdplaPPPVFARSLGKALAALHSIPADLAAAaGLPV----YTAEEVR----------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 164 KSVQLEIDEV-------------YRRILQQD----FHYQkcLIHNDFGASNVYYDQATNqICGLIDFGDVAIYD--RDME 224
Cdd:cd05152   148 ARMAARMDRVketfgvppallarWQAWLADDslwpFHTV--LVHGDLHPGHILVDEDGR-VTGLIDWTEAKVGDpaDDFA 224

                         250       260
                  ....*....|....*....|...
gi 2525148015 225 FVCLMFDyeegfnQEFVQKLMVA 247
Cdd:cd05152   225 WHYAAFG------EEALERLLDA 241
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
 154-256 1.31e-04

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 42.99  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525148015 154 IKQAAYPLLPKSVQL-----EIDEVYRRILQQDFHYQKCLIHNDFGASNVYYDQatNQICGLIDFGDV----AIYDrdme 224
Cdd:COG2334   142 LERLLGPLLPDPEDRalleeLLDRLEARLAPLLGALPRGVIHGDLHPDNVLFDG--DGVSGLIDFDDAgygpRLYD---- 215

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2525148015 225 F-VCLMFDYEEGFNQEFVQKLMVA----CEIDPNEIQ 256
Cdd:COG2334   216 LaIALNGWADGPLDPARLAALLEGyravRPLTEAELA 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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