|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
12-531 |
0e+00 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 600.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 12 SALAPFRHGIFRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIA 91
Cdd:pfam05977 2 SPLAPLRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 92 QIFMLVVSVLLTVFTYLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGI 171
Cdd:pfam05977 82 QLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 172 IVAAAGAAAAFAANALSYVGLLIVLARWKPDLPASTLPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALL 251
Cdd:pfam05977 162 LLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 252 PLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACW 331
Cdd:pfam05977 242 PLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAW 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 332 VIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLLPLPQQAVL 411
Cdd:pfam05977 322 ITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRLPEGEAA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 412 NLDPTNRFKEPHLALDLKLRSGPIAIMIEYIIREEDVPEFLATMAERGRIRRRDGARNWTLARDLENPAIWIEHYHTPTW 491
Cdd:pfam05977 402 DLIPSNHWPEPLVALAVKPRRGPVLVLIEYSIDKEDIPAFLKAMAELRRERRRDGAYGWGLTRDLANPEVWVETFMVESW 481
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2525285247 492 LEYIRHNKRATHADAVVGERVRALHSGDEPPRVRRMI--ERP 531
Cdd:pfam05977 482 AEHLRHHQRVTAADADVQDKVTAFHSGKEPPQVRHSLsiERP 523
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
22-403 |
2.28e-71 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 233.28 E-value: 2.28e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 22 FRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVL 101
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 102 LTVFTYLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAA 181
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 182 FAANALSYVGLLIVLARWKPDLPASTLPRE-TLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVK 260
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSsLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 261 GDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNV 340
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2525285247 341 TVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-368 |
2.07e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.09 E-value: 2.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 12 SALAPFRHGIFRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIA 91
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 92 QIFMLVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGI 171
Cdd:COG2814 82 LLLFALGSLLCALAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 172 IVAAAGAAAAFAANALSYVGLLIVLARWKPDlpastlPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALL 251
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPE------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 252 PLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACW 331
Cdd:COG2814 231 PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 2525285247 332 VIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIAL 368
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-289 |
2.49e-26 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 110.49 E-value: 2.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 22 FRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVL 101
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 102 LTVFTYLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAA 181
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 182 FAANALSYV--GLLIVLAR--WKPDLPASTLPRETLgAAMGAGLRYVAMSPNIGKVLVRGAAFGF-SAGAVLALLPLVAR 256
Cdd:TIGR00900 161 IWVDAVGFAisALLIVSVRipELAASEIQALSNAVL-RDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQS 239
|
250 260 270
....*....|....*....|....*....|...
gi 2525285247 257 DVVKGDALTYGIMLGAFGIGAVGGALISVRLRQ 289
Cdd:TIGR00900 240 KYLGRGSTHYGWVLAAFGLGALLGALLLGLLGR 272
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-403 |
1.08e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 105.74 E-value: 1.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 53 SSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNP 132
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT-----SYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 133 SWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDLPASTLPRET 212
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 213 LGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILS 292
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 293 SETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWI 372
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
330 340 350
....*....|....*....|....*....|.
gi 2525285247 373 WGVVADAHGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:cd17325 344 GGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-370 |
5.44e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 5.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 27 SASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFT 106
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 107 ylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANA 186
Cdd:pfam07690 84 -----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 187 LSYVGLLIVLARWKPDLPASTLPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVArDVVKGDALTY 266
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 267 GIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFN---AAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQ 343
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGlllLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 2525285247 344 MSTPRWVVGRVLSVYQTATFGGIALGS 370
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
18-403 |
3.71e-18 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 86.96 E-value: 3.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 18 RHGIFRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLV 97
Cdd:PRK10489 15 THPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 98 VSVLLTVFTYLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAG 177
Cdd:PRK10489 95 GFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 178 AAAAFAANALSYVGLLIVLARWkPDLPASTLPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFsAGAVLALLPLVARD 257
Cdd:PRK10489 175 VAWNYGLAAAGTFITLLPLLRL-PALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTM-ASAVRVLYPALADE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 258 VVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIA-LS 336
Cdd:PRK10489 253 VWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISsLL 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2525285247 337 HFNVtVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVAdahgaefALIGAAVAMLTGGAIGLLL 403
Cdd:PRK10489 333 QYTL-LQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLG-------AMMTPVASASASGFGLLII 391
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-399 |
7.57e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 7.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 25 VWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTV 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 105 FTYLglitpWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAA--AAF 182
Cdd:cd06174 81 APSF-----WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 183 AANALSYVGLLIVLARWKPDLPASTLPRETLG--AAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVK 260
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEAssKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 261 GDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMV-RMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFN 339
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLlLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2525285247 340 VTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADA-HGAEFALIGAAVAMLTGGAI 399
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
46-399 |
6.97e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.54 E-value: 6.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 46 MMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIfmlvvsvLLTVFTYLGLITP--WTLLAFAFLI 123
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLL-------LFGIGGLLCGLSDsfALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 124 NSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDL 203
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 204 PASTLPRETLGAAMGAGLRYvamsPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIGAVGGALI 283
Cdd:cd17474 178 EKAKSSSATKLRDLKKALRG----RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 284 SVRLRQI-LSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTAT 362
Cdd:cd17474 254 VGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 2525285247 363 FGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAI 399
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-404 |
2.17e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.60 E-value: 2.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 16 PFRHGIFRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFM 95
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 96 LVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIggiivaa 175
Cdd:COG2271 86 GLATLLFGFAT-----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 176 agaaaafaanalsyVGLLIVLARWkpdlpastlpRETLGAAMGAGLryVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVA 255
Cdd:COG2271 154 --------------LGWLLAAFGW----------RAAFLILGLPGL--LLALLRFWLLALAYFLVYFALYGFLTWLPTYL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 256 RDVVKGDALTYGIMLGAFGIGAVGGALISVRL--RQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVI 333
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLsdRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2525285247 334 ALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLLP 404
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
51-407 |
4.69e-14 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 75.35 E-value: 4.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 51 ATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTYLGLitPWTLLAFAFLINSGTALY 130
Cdd:PRK08633 43 SEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGW--FWLAFAVTFLLGAQSAIY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 131 NPSWQASVGDMVPRAKLPA-----------AVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLliVLARW 199
Cdd:PRK08633 121 SPAKYGIIPELVGKENLSRanglleaftivAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGL--IFAYR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 200 KPDLPASTLPRET-----LGAAMGAGLRYVAMSPNIGKVLVrGAAF--GFSAGAVLALLPLVARDVVKGDALTYGIMLGA 272
Cdd:PRK08633 199 LPKVPAAAPEVFDkkkylFPKLLWRNLKLLRSDRVLWLAII-GLSYfwFISQLAQANFPAYAKEVLGLDNTFQVQYLLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 273 FGIGAVGGALISVRL--RQIlssET-MVRMAFVGFALCAFNAAVSDHAWQTSLGLL---IGGACWVIALshfNVTVQMST 346
Cdd:PRK08633 278 SAIGIGIGSLLAGRLsgRHI---ELgLVPLGALGLALSLFLLPTAPSLASVLVLFFlfgFSAGLFIVPL---NALIQFRA 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2525285247 347 PRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLLPLPQ 407
Cdd:PRK08633 352 PEKELGKVLAANNFLQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLYTLLLLPD 412
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-403 |
9.75e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 73.03 E-value: 9.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 23 RAVWSASLVSNFGGliqgvGAAWMMTTIATSSYQ-VALVQASTTLPIM-----LFALVAGAIADSFNRRKVMLIAQIFML 96
Cdd:cd17329 2 WVLLIGSFLNRLGF-----FMVWPFMAIYLHQQLgLSASIVGLVLALSavagiVASLIGGRLADRFGRKPVMLAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 97 VVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGgIIVAAA 176
Cdd:cd17329 77 LGFALLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 177 GAAAAFAANALSYVGLLIVLARWKPDLPASTLPREtlGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVAR 256
Cdd:cd17329 151 SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAE--KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 257 DVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSdhawQTSLGLLIGGACW----V 332
Cdd:cd17329 229 EILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA----NTLAVLILAMIVLtlgeM 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2525285247 333 IALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGaaVAMLTGGAIGLLL 403
Cdd:cd17329 305 LVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI--LAALGLIAAALLL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-394 |
3.62e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.04 E-value: 3.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 56 QVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAqIFMLVVSVLLTVFTYlgliTPWTLLAFAFLINSGTALYNPSWQ 135
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVL-LLLFILGNLLAALAP----SFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 136 ASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDLPASTLPRETLGA 215
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 216 AMGAGLRyvamSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRlrqiLSSET 295
Cdd:cd17324 190 SLLLLLR----NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR----LADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 296 MVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMstprWVV-------GRVLSVYQTATFGGIAL 368
Cdd:cd17324 262 GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT----RVLrlapearGLASSLYLAAYNLGGAL 337
|
330 340
....*....|....*....|....*.
gi 2525285247 369 GSWIWGVVADAHGAEFALIGAAVAML 394
Cdd:cd17324 338 GAALGGLVLDHGGWAGVGWVGAALLL 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-403 |
1.74e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.11 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 56 QVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQ 135
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP-----SYPLLLLALFLLGLGLGLLDVAAN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 136 ASVGDMVPRAK---LPAAVALNSLGFnltrSVGPAIGGIIVAAAGAAAAFAA-NALSYVGLLIVLARWKPDLPASTlPRE 211
Cdd:COG0738 119 PYVAALGPETAasrLNLLHAFFSLGA----LLGPLLGGLLILLGLSLSWHLPyLILAVLLLLLALLFLRSKLPEIE-EEE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 212 TLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQIL 291
Cdd:COG0738 194 EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 292 SSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGAC----WVIALSHFNVTVQMSTprwvvGRVLSVYQTATFGGIA 367
Cdd:COG0738 274 GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlslmFPTIFSLALDGLGKRT-----AAAVSAVLIMGIVGGA 348
|
330 340 350
....*....|....*....|....*....|....*.
gi 2525285247 368 LGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:COG0738 349 IGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-404 |
2.12e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 59 LVQASTTLP---IMLFALVAGAIADSFNRRKVMLIAqifmlvvSVLLTVFTYLGLITP--WTLLAFAFLINSGTALYNPS 133
Cdd:cd17473 36 LVPLLLTLPalfIALFAPLAGWLADRFGRKRLLIAG-------LLLYGIGGVAGLFLDslYALLASRALLGIGVAGIMTL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 134 WQASVGDMV---PRAKLPA-AVALNSLGFNLTRSVGpaiggiivaaagaaaafaaNALSYVG-------------LLIVL 196
Cdd:cd17473 109 ATALIGDYFegeERAKMLGlQSAAMSLGGVVFLLLG-------------------GALAEIGwrapflvyllalpVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 197 ARWKPDLPASTLPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFgfsaGAVLALLPLVARDVVKGDALTYGIMLGAFGIG 276
Cdd:cd17473 170 LLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLF----YVIPIQLPFLLQERGGGSAALIGLALAIASLA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 277 AVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLS 356
Cdd:cd17473 246 GAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2525285247 357 VYQTATFGGIALGSWIWG-VVADAHGAEFALIGAAVAMLTGGAIGLLLP 404
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGpLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-404 |
3.23e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.81 E-value: 3.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 46 MMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTylgliTPWTLLAFAFLINS 125
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP-----SLAFLIAARALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 126 GTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAiggiivaaagaaaafaanalsYVGLLIVLARWkpdlpa 205
Cdd:cd17321 97 GAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPL---------------------LGGLLLELFGW------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 206 stlpRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIGAVGGALISV 285
Cdd:cd17321 150 ----RWIFLINVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 286 RLRQILSSETMVR----MAFVGFALCAFnAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTA 361
Cdd:cd17321 226 RLADRFGPRLVLVagllLTAVGLLLLAL-LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2525285247 362 TFGGIALGSWIWGVV-----------------------ADAHGAEFALIGAAVAMLTGGAIGLLLP 404
Cdd:cd17321 305 RQLGGALGVALLGALltaglsanlgdsgvaallsaaaaAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-169 |
3.98e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 17 FRHGIFRAVWSASLVSNFG-GLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFM 95
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAfGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2525285247 96 LVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIG 169
Cdd:cd17325 276 AVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-403 |
1.59e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 53 SSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLltvftYLGLITPWTLLAFAFLINSGTALYNP 132
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL-----YLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 133 SWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAI-GGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDLPASTLPRE 211
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALgLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 212 TLGAAMGAgLRYVAMSPNIGKVLvrgaaFGFSAGAVLALLPLVARDvvKGDAlTYGIMLGAFGIGAVGGALISVRLRQIL 291
Cdd:cd17489 184 GTRAFRRL-VEKKVLPPALILFL-----ASIAYGAISTFLPLYAAE--RGIS-NAGLFFTVYAIALLLSRPFSGKLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 292 SSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSW 371
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334
|
330 340 350
....*....|....*....|....*....|..
gi 2525285247 372 IWGVVADAHGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:cd17489 335 LLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-410 |
1.81e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 23 RAVWSASLVSNFGGLIQ---GVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVS 99
Cdd:COG2223 5 RVLLLATLAFFLAFGVWylwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 100 VLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAA 179
Cdd:COG2223 85 LLLALAV-----SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 180 AAFAANALSYVGLLIVLARWKPDLPASTLPREtlgAAMGAGLRYVAMSPnigKVLVRGAAFGFSAGAVLAL---LPLVAR 256
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAA---KASLRDQLEALRDP---RFWLLSLLYFGTFGSFIGFsswLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 257 DVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDH-AWQTSLGLLIGGACWVIAL 335
Cdd:COG2223 234 DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGN 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2525285247 336 SHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGA-EFALIGAAVAMLTGGAIGLLLPLPQQAV 410
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-405 |
2.01e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.51 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 46 MMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAqIFMLVVSVLLTVFTylglITPWTLLAFAFLINS 125
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAG-LLLFILASLLCALA----SSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 126 GTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPdlpa 205
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 206 STLP---RETLGAAMGAGLRYVAMSPnigKVLVRGAAFGFSAGAVLALL---PLVARDVVKGDALTYGIMLGAFGIGAVG 279
Cdd:cd17320 176 ETLPeekRKPLLSSLLRAYKRVLKNR---RFLGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 280 GALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWV---IALSHFNVTVQMSTP-RWVVGRVL 355
Cdd:cd17320 253 GSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIffgFGLIFPNATSLALEPfPHVAGTAS 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2525285247 356 SVYQTATFGGIALGSWIwgvVADAHGAEFALIGAAVAMLTGGAIGLLLPL 405
Cdd:cd17320 333 ALLGFLQFLIGALAGAL---VGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-401 |
4.20e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 4.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 46 MMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAqifMLVVSVLLTVFTYLGliTPWTLLAFAFLINS 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG---PLLTGLGLSLLGFAP--NYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 126 GTALYNPSwQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDLPA 205
Cdd:cd17478 97 GSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 206 StlpRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDvVKGDALTYGIMLGAFGIGAVGGALISV 285
Cdd:cd17478 176 E---AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 286 RLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWViALSHFNVTVQMSTPRwVVGRVLSVYQTATFGG 365
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFA-SFPVTVVLAQELLPG-NVGLASGLMMGLSFGL 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 2525285247 366 IALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGL 401
Cdd:cd17478 330 GGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
29-403 |
1.48e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 29 SLVSNFGGLIQGVGAAWMMTTIAT-SSYQVALVQASTTLPIMLFALVAGAIADSFN-----RRKVMLIAQIFMLVVSVLL 102
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 103 -TVFTYLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVP----RAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAG 177
Cdd:COG2211 99 fTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdyeeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 178 AAAAFAANALS---YVGLLIVLARWKPDLPASTLPRETLGAAMGAGLRYVAMspniGKVLVRGAAFGFSAGAVLALLPLV 254
Cdd:COG2211 179 ALGYRLTALIFavlGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPF----LLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 255 ARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALC--AFNAAVSDHAWQTSLGLLIGGACWV 332
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGllLLFFLGPGNLWLLLVLAALAGIGLG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 333 IALSHFNVTV-------QMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHG-------AEFALIGAAVAMLTGGA 398
Cdd:COG2211 335 AILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPA 414
|
....*
gi 2525285247 399 IGLLL 403
Cdd:COG2211 415 VLLLL 419
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-306 |
3.20e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.04 E-value: 3.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 24 AVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLT 103
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 104 VftylgLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFA 183
Cdd:COG0477 98 L-----APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 184 ANALSYVgLLIVLARWKPDLPASTLPRETLGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDA 263
Cdd:COG0477 173 INAPLGL-LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2525285247 264 LTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFAL 306
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
57-309 |
9.18e-06 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 48.81 E-value: 9.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 57 VALVQASTTLPIMLFALVAGAIADSFNRRKVMLI---AQIFMLVVSVLLTVFTYLglitpWTLLAFAFLINSGTALYNPS 133
Cdd:PRK06814 54 VTLAGAVFILPFFIFSALAGQLADKYDKAKLAKIlkfAEIGIAALAIYGFHLNSV-----PLLFAALFLMGIHSALFGPI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 134 WQASVGDMVPRAKLPAAVALNSLGFNLTRSVGP-AIGGIIVAAAGAAAAFAANALSYVGLLIVLARWK-----PDLPAST 207
Cdd:PRK06814 129 KYSILPDHLNKDELLGANALVEAGTFIAILLGTiIGGLATISGNFVILVALLMGIAVLGWLASLFIPKtgnaaPDLKIDR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 208 LP-RETLGAamgagLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIG-AVGGALISv 285
Cdd:PRK06814 209 NIiRSTITL-----LKYAKADKRIWLAILGISWFWLVGAVVLSQLPLLAKETLGGDENVATLFLAVFSVGvAVGSFLAS- 282
|
250 260
....*....|....*....|....
gi 2525285247 286 rlrQILSSETMVRMAFVGFALCAF 309
Cdd:PRK06814 283 ---KLSEGRITLLYVPIGALLMGL 303
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
64-403 |
1.04e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 64 TTLPIMLFAL---VAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASVGD 140
Cdd:COG2807 59 TTLPLLAFGLfapLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP-----SVALLLAGTALIGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 141 MVPRaKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALsyVGLLIVLARWkpdLPASTLPRETLGAAMGAG 220
Cdd:COG2807 134 WFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL--LALLALLLWL---PLLRRRPAAAAAAPAAAS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 221 LRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDvvKG-DALTYGIMLGAFGIGAVGGALISVRL-----RQILSSE 294
Cdd:COG2807 208 LRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD--AGlSAATAGLLLSLFQLAGIPGSLLVPLLadrlgDRRPLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 295 TMVRMAFVGFALCAFNAAVSDHAWQTSLGLlIGGACWVIALSHFnvtVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWG 374
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWAVLLGL-GQGGLFPLALTLI---GLRARTPAEAAALSGMAQSVGYLLAALGPLLVG 361
|
330 340 350
....*....|....*....|....*....|
gi 2525285247 375 VVADA-HGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:COG2807 362 ALHDAtGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
237-403 |
1.27e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 237 GAAFGFSAGAVLALLPLVARDVvKGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDH 316
Cdd:COG2814 19 AFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 317 AWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTG 396
Cdd:COG2814 98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177
|
....*..
gi 2525285247 397 GAIGLLL 403
Cdd:COG2814 178 LLLLLRL 184
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
239-404 |
1.52e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 239 AFGFSAGAVLALLPLVARDVVKGDALTyGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAW 318
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 319 QTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGA 398
Cdd:cd17325 86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165
|
....*.
gi 2525285247 399 IGLLLP 404
Cdd:cd17325 166 LALLLL 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-147 |
1.84e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 3 DDEPDSERVSALAPFRHGIFRAVWSASLVSNFGGLIQGVGAAWMMT-TIATSSYQVALVQASTTLPIMLFALVAGAIADS 81
Cdd:COG2211 211 EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2525285247 82 FNRRKVMLIAQIFMLVVSVLLTVftyLGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKL 147
Cdd:COG2211 291 FGKKKAFIIGLLLAALGLLLLFF---LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEW 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-166 |
6.71e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 10 RVSALAPFRHGIFRAVWSASLVSNFGGLIQGVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVML 89
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2525285247 90 IAQIFMLVVSVLLTVFTylGLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGP 166
Cdd:pfam07690 270 LALLLLILAALGLLLLS--LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
53-394 |
1.40e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.11 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 53 SSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTYLglitpWTLLAFAFlINSGTALYNP 132
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL-----WLLFLARF-LDGLTGGNVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 133 SWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPaiggiivaaagaaaafaanalsyvglliVLARWKPDLPASTLPreT 212
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGP----------------------------ALGGFLSTPYGYALP--F 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 213 LGAAMGAGLRYVAMS---PNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGI-GAVGGALISVRLR 288
Cdd:cd17330 156 LVAAALALLNLVLVLfflPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIaGILAQLLLIPRLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 289 QILSSETMVR----MAFVGFALCAFnAAVSDHAWQTSLGLLIGGAcwvIALSHFNVTVQMSTPRWVVGRVLSVYQTATFG 364
Cdd:cd17330 236 KRLGERKLLRlgllLAIIGLLLLPF-ASSVPLLVLAAAILAFGTG---IVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311
|
330 340 350
....*....|....*....|....*....|
gi 2525285247 365 GIALGSWIWGVVADAHGAEFALIGAAVAML 394
Cdd:cd17330 312 ARIIGPLLAGPLYSFLGPGVPFLLAAGLLL 341
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
40-158 |
1.51e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.10 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 40 GVGAAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTYLGLITPWTLLAF 119
Cdd:cd17320 222 AAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAP 301
|
90 100 110
....*....|....*....|....*....|....*....
gi 2525285247 120 AFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGF 158
Cdd:cd17320 302 LFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQF 340
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
240-409 |
2.04e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 240 FGFSAGAVLALLPLVARDVVKGDALTyGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDHAWQ 319
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 320 TSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAI 399
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL 166
|
170
....*....|
gi 2525285247 400 GLLLPLPQQA 409
Cdd:cd17489 167 VFLVKDPPPV 176
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
59-166 |
4.68e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 59 LVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTylgliTPWTLLAFAFLINSGTALYNPSWQASV 138
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQ-----TPWQLGILRFLLGLATGGLLPAINSLL 318
|
90 100
....*....|....*....|....*...
gi 2525285247 139 GDMVPRAKLPAAVALNSLGFNLTRSVGP 166
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGP 346
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-403 |
5.41e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 39 QGVG--AAWMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAQIFMLVVSVLLTVFTYLglitpWTL 116
Cdd:cd17475 13 QGIPalAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY-----PVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 117 LAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVL 196
Cdd:cd17475 88 LVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 197 ARWKPDLPASTLPRETlGAAMGAGLRYVAMSPNIGKVLVRGAAFGFSAGAVLALLPLVARDVVKGDALTYGIMLGAFGIG 276
Cdd:cd17475 168 WLFYREPPAASAATES-ASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 277 AVGG----ALISVRLRqilSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACW--VIALS----HFNVTVQMST 346
Cdd:cd17475 247 GALGriglGRVSDRVF---GGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILlgLFAIGwnglYLTLVAESAG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2525285247 347 PRWvVGRVLSVYQTATFGGIALGSWIWGVVADAHGAeFALIGAAVAMLTGGAIGLLL 403
Cdd:cd17475 324 PEQ-AGTALGLANTINFIGIAIGPPLFGLLVDATHS-YAPAWLALALLLVLAALLLL 378
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
56-405 |
1.05e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 56 QVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIaqifmlvVSVLLTVFTYLGLITPW-TLLAFAFLINSGTALYNP-- 132
Cdd:cd17335 33 QIGILIGIRPFVRFLSAPLWGALADRFGKRKALLL-------LSLLAAVLFFLSLFFVAqIFWLLLLLVILGAFFSAPvv 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 133 --------SWQASVGDMVPRAKLpaavaLNSLGFNLTR-SVGPAIGGIIVAAAGAAAAFAANALSyvgLLIVLARWKPDL 203
Cdd:cd17335 106 plvdsitlQYLGEERERYGKQRL-----WGSIGFGIAAlLVGILIDRSSTYKNYTIAFYVFAVLM---LLALLLALKFPF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 204 PASTLPRETLGAAMGAGLRyvamSPNIGKVLVRGAAFGFSAGAVLALLPLVARDvVKGDALTYGImlgAFGIGAVGGALI 283
Cdd:cd17335 178 RPKHPEPNENTGGLLALLR----NPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGL---LWTVGVVSEIPF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 284 ---SVRLRQILSsetMVRMAFVGFALCAFNAAVsdHAWQTSLGLLIG---------GACWVIALSHfnvtVQMSTPRWVV 351
Cdd:cd17335 250 fffSSRLIQRFG---HVGLLYLGLLAYVVRWLL--YSFLENPWLVLPiellhgltfALVWAAAVSY----ASAAAPPGLR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2525285247 352 GRVLSVYQTATFG-GIALGSWIWGVVADAHGAEFALIGAAVAMLTGGAIGLLLPL 405
Cdd:cd17335 321 ATAQGLLQGLYFGlGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| YgiN |
COG1359 |
Quinol monooxygenase YgiN [Energy production and conversion]; |
435-527 |
1.69e-03 |
|
Quinol monooxygenase YgiN [Energy production and conversion];
Pssm-ID: 440970 Cd Length: 91 Bit Score: 37.62 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 435 IAIMIEYIIREEDVPEFLATMAE-RGRIRRRDGARNWTLARDLENPAIW--IEHYHTPTWLEyiRHNKRAtHADAVVgER 511
Cdd:COG1359 1 ITVIAKLTVKPGKRDEFLAALRElVEATRAEPGCLSYELYRDPDDPNRFvlYERWEDEAALE--AHLASP-HFKAFL-AA 76
|
90
....*....|....*.
gi 2525285247 512 VRALhsGDEPPRVRRM 527
Cdd:COG1359 77 LAPL--LAEPPEVRVY 90
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
59-395 |
2.51e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 40.44 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 59 LVQASTTLPIMLFA---LVAGAIADSFNRRKVMLIAqIFMLVVSVLLTVFTYlgliTPWTLLAFAFLINSGTALYNPSWQ 135
Cdd:TIGR00710 41 IVQMTLTLYLLGFAagqLLWGPLSDRYGRRPVLLLG-LFIFALSSLGLALSN----NIETLLVLRFVQAFGASAGSVISQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 136 ASVGDMVPRAKLPAAVALNSLGFNLTRSVGPAIGGIIVAAAGAAAAFAANALSYVGLLIVLARWKPDlpasTLPREtlgA 215
Cdd:TIGR00710 116 ALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPE----TLPYE---A 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 216 AMGAGLRYVAMSPNIGKVLVRGAAF--GFSAGAVLALL---PLVARDVVKGDALTYGIMLGAFGIGAVGGALISVRLRQI 290
Cdd:TIGR00710 189 RIQISTYFETFLLLLKSKMFWGYALiyGASFGGFFAFFsgaPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKK 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 291 LSSETMVRMAFVGFALCAF---NAAVSDH-AWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGgi 366
Cdd:TIGR00710 269 WGAKSLLRMGLILFAVSAVlleITAILGLgSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLV-- 346
|
330 340
....*....|....*....|....*....
gi 2525285247 367 aLGSWIWGVVADAHGAEFALIGAAVAMLT 395
Cdd:TIGR00710 347 -LGAIVGYLVSLIHGNTAWPMSLSCLVLA 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
21-165 |
4.25e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.47 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 21 IFRAVWSASLVSNFGGLIQGVGAA----WMMTTIATSSYQVALVQASTTLPIMLFALVAGAIADSFNR-RKVMLIAQIFM 95
Cdd:cd17502 165 LLRTILLSSIFGFLFGGALFGLIYylplYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILM 244
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 96 LVVSVLLTVFTYlgLITPWTLLAFAFLINSGTALYNPSWQASVGDMVPRAKLPAAVALNSLGFNLTRSVG 165
Cdd:cd17502 245 SVGAGLLTTLTL--DTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG 312
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-439 |
5.72e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 237 GAAFGFSAGAVLALLPLVARDVVkGDALTYGIMLGAFGIGAVGGALISVRLRQILSSETMVRMAFVGFALCAFNAAVSDH 316
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 317 AWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRVLSVYQTATFGGIALGSWIWGVVADAHGAEFA---LIGAAVAM 393
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRavfLIAAALAL 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2525285247 394 LTGGAIGLLLPLPQQAVLNLDPTNRFKEPHLALDLKLRSGPIAIMI 439
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLL 209
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-128 |
5.78e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 5.78e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2525285247 53 SSYQVALVQASTTLPIMLFALVAGAIADSFNRRKVMLIAqIFMLVVSVLLTVFTylglITPWTLLAFAFLINSGTA 128
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLS-TLVTAVSGVLTAFS----PNYTVFLVFRLLVGMGIG 195
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
275-403 |
6.31e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 275 IGAVGGALISVRLrQILSSETMVRMAFVGFALCAFNAAVSDHAWQTSLGLLIGGACWVIALSHFNVTVQMSTPRWVVGRV 354
Cdd:cd17319 230 IGMILGGRLSDRL-LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
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90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2525285247 355 LSVYQTATFGGIALGSWIWGVVADA-HGAEFALIGAAVAMLTGGAIGLLL 403
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
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| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-165 |
7.47e-03 |
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Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.76 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525285247 59 LVQASTTLPIMLFALVAGAIADSFNRRKVMLIAqIFMLVVSVLLTVFTYlgliTPWTLLAFAFLINSGTALYNPSWQASV 138
Cdd:cd17328 38 LLQTVFIISYMVLSPIFGYLGDRYNRKWILAVG-ILIWSAATLLSSFAP----NFWQLLLFRALVGIGEASYSPIAPTII 112
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90 100
....*....|....*....|....*..
gi 2525285247 139 GDMVPRAKLPAAVALNSLGFNLTRSVG 165
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLG 139
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