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Conserved domains on  [gi|2525417458|ref|WP_287234660|]
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calcium-binding protein [Microcystis sp. Msp_OC_L_20101000_S702]

Protein Classification

calcium-binding protein( domain architecture ID 11458495)

RTX toxin-related calcium-binding protein belongs to the serralysin-like M10 metalloprotease family, such as Bordetella pertussis adenylate cyclase toxin

CATH:  2.150.10.10|3.40.390.10
Gene Ontology:  GO:0005509
PubMed:  32860773|27058787|1558765
SCOP:  4002779|3001975

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.32e-12

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 63.00  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    35 GGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   115 LTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGND 194
 
Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.32e-12

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 63.00  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    35 GGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   115 LTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGND 194
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 108-157 7.12e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 41.59  E-value: 7.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2525417458 108 GSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWEND 157
Cdd:pfam08548  87 GSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD 136
 
Name Accession Description Interval E-value
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.32e-12

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 63.00  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    35 GGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   115 LTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGND 194
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 1.14e-11

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 61.08  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    44 GGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.07e-11

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 60.30  E-value: 2.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    26 GGGGGGGGGGGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFgLYGGDGN 166
Cdd:COG2931   106 GDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDT-LTGGAGN 184
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 1.31e-10

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 57.99  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    55 GGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLY 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 fiATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   135 --GGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 3.50e-10

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 56.84  E-value: 3.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931    17 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFgLYGGDGN 166
Cdd:COG2931    97 GGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDT-LDGGAGN 175
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 7.97e-09

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 52.99  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGsGADNLN 86
Cdd:COG2931    63 GGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYG-GAGNDT 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   142 LTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDD 221
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.48e-08

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 51.45  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931     8 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFgLYGGDGN 166
Cdd:COG2931    88 DGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDT-LYGGAGN 166
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 6.87e-07

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.59  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQItpITITYTDTQVVTSGVGDTFKAIEGIYLLSGsGADNLN 86
Cdd:COG2931    74 GGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDT--LTGGDGNDTLTGGAGDDTLYGGAGNDTLTG-GAGNDT 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   151 LYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDD 230
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 9-166 2.36e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 46.05  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   9 NDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDYSAQITPITITYTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLNFI 88
Cdd:COG2931     1 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2525417458  89 ATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFgLYGGDGN 166
Cdd:COG2931    81 GGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDT-LYGGAGN 157
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 108-157 7.12e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 41.59  E-value: 7.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2525417458 108 GSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWEND 157
Cdd:pfam08548  87 GSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD 136
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-166 2.73e-04

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 39.89  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLgldysaqitpitITYTDTQVVTSGVGDTFkaiegiyLLSGSGADNLN 86
Cdd:COG2931   119 DGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTL------------YGGAGNDTLYGGAGNDT-------LDGGAGNDTLT 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458  87 fiatslnsniqGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSGGAGNDGDYYDWENDFGLYGGDGN 166
Cdd:COG2931   180 -----------GGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGDD 248
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 7-143 1.01e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 38.35  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2525417458   7 NGNDILNGGSEDDYLDGGAGSDTIDGGSGNDNLGLDysaqitpitityTDTQVVTSGVGDTFKAIEGIYLLSGSGADNLN 86
Cdd:COG2931   128 AGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGG------------AGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDT 195

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2525417458  87 FIATSLNSNIQGGGGNDFIALGSGNDSLYGQDGNDTLNSGGGQDRLEGGDGDDLLSG 143
Cdd:COG2931   196 LDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGDDGLGG 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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