|
Name |
Accession |
Description |
Interval |
E-value |
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
1-303 |
9.83e-168 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 467.32 E-value: 9.83e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 1 MQRLQSSlVSDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEI 80
Cdd:COG4989 1 MKRIKLG-ASGLSVSRIVLGCMRLGEWDLSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKLSPSLREKIEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 81 VSKCSIRLAGEVSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSN 160
Cdd:COG4989 80 QTKCGIRLPSEARDNRVKHYDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVSN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 161 YLPHQTDLLQSRLSQPLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDAVRVQQALHALCESR 240
Cdd:COG4989 160 FTPSQFELLQSALDQPLVTNQIELSLLHTDAFDDGTLDYCQLNGITPMAWSPLAGGRLFGGFDEQFPRLRAALDELAEKY 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2526794215 241 GLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGRGREV 303
Cdd:COG4989 240 GVSPE----AIALAWLLRHPAGIQPVIGTTNPERIKAAAAALDIELTREEWYELYEAARGHEV 298
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
10-299 |
2.78e-148 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 417.34 E-value: 2.78e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKCSIRLA 89
Cdd:cd19092 2 EGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKCGIRLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 90 GEVSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLL 169
Cdd:cd19092 82 DDPRPGRIKHYDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIELL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 170 QSRLSQPLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDAVRVQQALHALCESRGldpqVGAM 249
Cdd:cd19092 162 QSYLDQPLVTNQIELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRLRAALEELAEEYG----VTIE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2526794215 250 QLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGR 299
Cdd:cd19092 238 AIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTREEWYEIYEAAR 287
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
10-291 |
3.42e-60 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 194.24 E-value: 3.42e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRL-TDWSYTPRER-LGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnPVLRERMEIVSKCSIR 87
Cdd:COG0667 9 SGLKVSRLGLGTMTFgGPWGGVDEAEaIAILDAALDAGINFFDTADVYGPGRSEELLGEALK--GRPRDDVVIATKVGRR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 LagevsGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTD 167
Cdd:COG0667 87 M-----GPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 LLQ--SRLSQPLVANQIEVSLLQSAPmFDGQLDYCQQHRVMPMAWSPFAGGRL---------------------FRGDDG 224
Cdd:COG0667 162 RALaiAEGLPPIVAVQNEYSLLDRSA-EEELLPAARELGVGVLAYSPLAGGLLtgkyrrgatfpegdraatnfvQGYLTE 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2526794215 225 DAVRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDW 291
Cdd:COG0667 241 RNLALVDALRAIAAEHGVTPA----QLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDL 303
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
17-294 |
9.74e-58 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 187.13 E-value: 9.74e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRLTD--WSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKCSIRLAGevsg 94
Cdd:pfam00248 1 IGLGTWQLGGgwGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDGP---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 95 ariNHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLS 174
Cdd:pfam00248 77 ---WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 175 QPLVANQIEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRL-------FRGDDGDAVRVQ-----------QALHAL 236
Cdd:pfam00248 154 IPIVAVQVEYNLLRRRQE-EELLEYCKKNGIPLIAYSPLGGGLLtgkytrdPDKGPGERRRLLkkgtplnlealEALEEI 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 237 CESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:pfam00248 233 AKEHGVSPA----QVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARI 286
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
15-280 |
3.19e-57 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 183.87 E-value: 3.19e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 15 SRIAFGLWRLtDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVlRERMEIVSKCsirlaGEVSG 94
Cdd:cd06660 1 SRLGLGTMTF-GGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGN-RDDVVIATKG-----GHPPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 95 ARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQT----DLLQ 170
Cdd:cd06660 74 GDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLaealAYAK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 171 SRLSQPLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGgrlfrgddgdavrvqqalhalcesrgldpqvGAMQ 250
Cdd:cd06660 154 AHGLPGFAAVQPQYSLLDRSPMEEELLDWAEENGLPLLAYSPLAR-------------------------------GPAQ 202
|
250 260 270
....*....|....*....|....*....|
gi 2526794215 251 LAVAWLLKHPAKMVPVLGSGNPERLVAALA 280
Cdd:cd06660 203 LALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
11-294 |
6.53e-52 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 172.33 E-value: 6.53e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 11 DFSLSRIAFGLWRL--TDWSYTPR-ERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIVSKCSIR 87
Cdd:cd19084 1 DLKVSRIGLGTWAIggTWWGEVDDqESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALK---GRRDDVVIATKCGLR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 lageVSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTD 167
Cdd:cd19084 78 ----WDGGKGVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 LLQSRLsqPLVANQIEVSLLQSApMFDGQLDYCQQHRVMPMAWSPFAGGRL---------------------FRGDD-GD 225
Cdd:cd19084 154 EARKYG--PIVSLQPPYSMLERE-IEEELLPYCRENGIGVLPYGPLAQGLLtgkykkeptfppddrrsrfpfFRGENfEK 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2526794215 226 AVRVQQALHALCESRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19084 231 NLEIVDKLKEIAEKYGKSL----AQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
16-290 |
3.24e-43 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 148.40 E-value: 3.24e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 16 RIAFGLWRLTDwSYTPRerlgLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirlagevsga 95
Cdd:cd19071 3 LIGLGTYKLKP-EETAE----AVLAALEAGYRHIDTAAAYGN---EAEVGEAIRESGVPREELFITTK------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 96 rINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAA------VLEQLVAEGKVRQLGVSNYLPHQTD-L 168
Cdd:cd19071 63 -LWPTDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEArletwrALEELVDEGLVRSIGVSNFNVEHLEeL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQSRLSQPLVaNQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRGDDgdavrvqQALHALCESRGLDPQvg 247
Cdd:cd19071 142 LAAARIKPAV-NQIELHpYLQQKEL----VEFCKEHGIVVQAYSPLGRGRRPLLDD-------PVLKEIAKKYGKTPA-- 207
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2526794215 248 amQLAVAWLLKHpaKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19071 208 --QVLLRWALQR--GVVVIPKSSNPERIKENLDVFDFELSEED 246
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
16-301 |
2.50e-41 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 143.66 E-value: 2.50e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 16 RIAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirLAGEvsga 95
Cdd:COG0656 7 ALGLGTWQLPG-----EEAAAAVRTALEAGYRHIDTAAMYGN---EEGVGEAIAASGVPREELFVTTK----VWND---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 96 riNH-YDtsatHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAvLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLS 174
Cdd:COG0656 71 --NHgYD----DTLAAFEESLERLGLDYLDLYLIHWPGPGPYVETWRA-LEELYEEGLIRAIGVSNFDPEHLEELLAETG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 175 QPLVANQIEVSL-LQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRgddgdavrvQQALHALCESRGLDPqvgAmQLAV 253
Cdd:COG0656 144 VKPAVNQVELHPyLQQREL----LAFCREHGIVVEAYSPLGRGKLLD---------DPVLAEIAEKHGKTP---A-QVVL 206
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2526794215 254 AWLLKHpaKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGRGR 301
Cdd:COG0656 207 RWHLQR--GVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGE 252
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
14-299 |
5.92e-40 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 141.18 E-value: 5.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRL---TDWSY-TPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIVSKCSIRla 89
Cdd:cd19085 1 VSRLGLGCWQFgggYWWGDqDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALK---GRRDDVVIATKVSPD-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 90 gevsgarinhyDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLL 169
Cdd:cd19085 76 -----------NLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 170 QSRlsQPLVANQIEVSLLQSAPMFDgQLDYCQQHRVMPMAWSPFAGG-------------------RLFR-GDDGDAVRV 229
Cdd:cd19085 145 LDA--GRIDSNQLPYNLLWRAIEYE-ILPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdartRLFRhFEPGAEEET 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2526794215 230 QQALHAL---CESRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGR 299
Cdd:cd19085 222 FEALEKLkeiADELGVTM----AQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDEISD 290
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
42-290 |
3.22e-39 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 139.63 E-value: 3.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDYRCEQAFGEALKlnpvlRERMEIV--SKCsirlaGEVSGARINHYDTSATHVRSAVETSLRDMG 119
Cdd:cd19087 40 LDAGINFFDTADVYGGGRSEEIIGRWIA-----GRRDDIVlaTKV-----FGPMGDDPNDRGLSRRHIRRAVEASLRRLQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 120 IEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQT----------DLLQSRLSQP---LVANQIEVSL 186
Cdd:cd19087 110 TDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIakaqgiaarrGLLRFVSEQPmynLLKRQAELEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 187 LqsaPMfdgqldyCQQHRVMPMAWSPFAGGRLF-------RGDDGDAVR---------------VQQALHALCESRGLDP 244
Cdd:cd19087 190 L---PA-------ARAYGLGVIPYSPLAGGLLTgkygkgkRPESGRLVEraryqarygleeyrdIAERFEALAAEAGLTP 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2526794215 245 qvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19087 260 ----ASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPEL 301
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
14-294 |
9.13e-39 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 138.13 E-value: 9.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLW----RLTDW--SYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvLRERMEIVSKcsir 87
Cdd:cd19093 2 VSPLGLGTWqwgdRLWWGygEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELG-DRDEVVIATK---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 LAGEvsgarinHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDP-LMDADALAAVLEQLVAEGKVRQLGVSNYLPHQT 166
Cdd:cd19093 77 FAPL-------PWRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 DLLQSRLSQ---PLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRL-------------FRGDDGDAVR-- 228
Cdd:cd19093 150 RRAHKALKErgvPLASNQVEYSLLYRDPEQNGLLPACDELGITLIAYSPLAQGLLtgkyspenpppggRRRLFGRKNLek 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2526794215 229 ---VQQALHALCESRGLDPQvgamQLAVAWLLKHPAkmVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19093 230 vqpLLDALEEIAEKYGKTPA----QVALNWLIAKGV--VPIPGAKNAEQAEENAGALGWRLSEEEVAEL 292
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
11-296 |
9.88e-39 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 136.98 E-value: 9.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 11 DFSLSRIAFGLWRLTDWSYTP----RERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnPVLRERMEIVSKcsi 86
Cdd:cd19072 1 GEEVPVLGLGTWGIGGGMSKDysddKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIK--GFDREDLFITTK--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 rlageVSGARINHYDtsathVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYlphQT 166
Cdd:cd19072 76 -----VSPDHLKYDD-----VIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNF---SL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 DLLQSRLSQ----PLVANQIEVSLLqSAPMFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDgdavrvQQALHALCESRGL 242
Cdd:cd19072 143 EELEEAQSYlkkgPIVANQVEYNLF-DREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKG------SPLLDEIAKKYGK 215
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2526794215 243 DPQvgamQLAVAWLLKHPaKMVPVLGSGNPERLVAALAALDMEMEREDwYELLR 296
Cdd:cd19072 216 TPA----QIALNWLISKP-NVIAIPKASNIEHLEENAGALGWELSEED-LQRLD 263
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
14-287 |
5.51e-38 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 135.04 E-value: 5.51e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRLT--DWSYTPRER---LGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlrERMEIVSKCSIRL 88
Cdd:cd19088 1 VSRLGYGAMRLTgpGIWGPPADReeaIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYP---DDVVIATKGGLVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 agevSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQtdL 168
Cdd:cd19088 78 ----TGPGWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQ--I 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQSRLSQPLVANQIEVSLLQSAPmfDGQLDYCQQHRVMPMAWSPFAGGRLFRGddgdavrvQQALHALCESRGLDPqvga 248
Cdd:cd19088 152 EEARAIVRIVSVQNRYNLANRDD--EGVLDYCEAAGIAFIPWFPLGGGDLAQP--------GGLLAEVAARLGATP---- 217
|
250 260 270
....*....|....*....|....*....|....*....
gi 2526794215 249 MQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEME 287
Cdd:cd19088 218 AQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
15-283 |
2.93e-37 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 134.22 E-value: 2.93e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 15 SRIAFGlwrlTDW--SYTPRERL-GLFEQMLDLGVTTFDLADIYGDY----RCEQAFGEALKLNPVlRERMEIVSKCSIR 87
Cdd:cd19082 1 SRIVLG----TADfgTRIDEEEAfALLDAFVELGGNFIDTARVYGDWvergASERVIGEWLKSRGN-RDKVVIATKGGHP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 LAGEVSGARINHYDtsathVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHqtd 167
Cdd:cd19082 76 DLEDMSRSRLSPED-----IRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTE--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 llqsRLS-----------QPLVANQIEVSL----------LQSAPMFDGQLDYCQQHRvMP-MAWSPFAGG---RLFRGD 222
Cdd:cd19082 148 ----RIAeanayakahglPGFAASSPQWSLarpneppwpgPTLVAMDEEMRAWHEENQ-LPvFAYSSQARGffsKRAAGG 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2526794215 223 DGDA------------VRVQQALHALCESRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19082 223 AEDDselrrvyyseenFERLERAKELAEEKGVSP----TQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
12-281 |
4.12e-37 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 132.22 E-value: 4.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 12 FSLSRIAFGLWRL-TDW--SYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNpvlRERMEIVSKCSIRL 88
Cdd:cd19086 1 LEVSEIGFGTWGLgGDWwgDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGR---RDKVVIATKFGNRF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 agevSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRP-DPLMDADALAAVLEQLVAEGKVRQLGVSnyLPHQTD 167
Cdd:cd19086 78 ----DGGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPpDEVLDNDELFEALEKLKQEGKIRAYGVS--VGDPEE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 LLQSRLSQPLVANQIEVSLLQSAPmFDGQLDYCQQHRVMPMAWSPFAGGRLfrgddgdavrvqqalhalcesrgldpqVG 247
Cdd:cd19086 152 ALAALRRGGIDVVQVIYNLLDQRP-EEELFPLAEEHGVGVIARVPLASGLL---------------------------TG 203
|
250 260 270
....*....|....*....|....*....|....*
gi 2526794215 248 AM-QLAVAWLLKHPAKMVPVLGSGNPERLVAALAA 281
Cdd:cd19086 204 KLaQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
11-297 |
3.86e-34 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 126.19 E-value: 3.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 11 DFSLSRIAFGLWRLTdWSYTP----RERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnPVlRERMEIVSKCSI 86
Cdd:cd19078 1 GLEVSAIGLGCMGMS-HGYGPppdkEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALK--PF-RDQVVIATKFGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 RLAGEVSGARInhYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVS----NYL 162
Cdd:cd19078 77 KIDGGKPGPLG--LDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSeagvETI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 163 --PHQTdllqsrlsQPLVANQIEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRL---------FRGDD-------- 223
Cdd:cd19078 155 rrAHAV--------CPVTAVQSEYSMMWREPE-KEVLPTLEELGIGFVPFSPLGKGFLtgkidentkFDEGDdraslprf 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2526794215 224 -GDAVRVQQALHALCESRGLDPQVGAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRA 297
Cdd:cd19078 226 tPEALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIEDA 300
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
14-290 |
7.47e-34 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 124.22 E-value: 7.47e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRLTDwSYTP-----RERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKcsirl 88
Cdd:cd19137 4 IPALGLGTWGIGG-FLTPdysrdEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFP--REDLFIVTK----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 agevsgarINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDL 168
Cdd:cd19137 76 --------VWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQSRLSQPLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGrlfrgddgdAVRVQQALHALCESRGLDPqvga 248
Cdd:cd19137 148 AISKSQTPIVCNQVKYNLEDRDPERDGLLEYCQKNGITVVAYSPLRRG---------LEKTNRTLEEIAKNYGKTI---- 214
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 249 MQLAVAWLLKHPaKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19137 215 AQIALAWLIQKP-NVVAIPKAGRVEHLKENLKATEIKLSEEE 255
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
15-281 |
1.23e-33 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 123.50 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 15 SRIAFGLWRL--TDWSYTPRERLGLFEQMLDLGVTTFDLADIYGdyRCEQAFGEALKlnPVLRERMEIVSKCsirlaGEV 92
Cdd:cd19095 1 SVLGLGTSGIgrVWGVPSEAEAARLLNTALDLGINLIDTAPAYG--RSEERLGRALA--GLRRDDLFIATKV-----GTH 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 SGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSR 172
Cdd:cd19095 72 GEGGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGEELEAAIASG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 173 LSQPLvanQIEVSLLQSApmFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDAVRVQQAlhALCESRGLDPQVGAMQLA 252
Cdd:cd19095 152 VFDVV---QLPYNVLDRE--EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYA--RRPEFAAEIGGATWAQAA 224
|
250 260
....*....|....*....|....*....
gi 2526794215 253 VAWLLKHPAKMVPVLGSGNPERLVAALAA 281
Cdd:cd19095 225 LRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
10-283 |
1.81e-33 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 124.68 E-value: 1.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYG--DYRCEQAFGEALKLN-PVLRERMEIVSKCSI 86
Cdd:cd19089 7 SGLHLPAISLGLWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGppPGSAEENFGRILKRDlRPYRDELVISTKAGY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 RLAGEVSGarinHYdTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQT 166
Cdd:cd19089 87 GMWPGPYG----DG-GSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 ----DLLqSRLSQPLVANQIEVSLLQSAPmFDGQLDYCQQHRVMPMAWSPFAGGRL----FRGDDGDAVRVQ-------- 230
Cdd:cd19089 162 rraiALL-RELGVPLIIHQPRYSLLDRWA-EDGLLEVLEEAGIGFIAFSPLAQGLLtdkyLNGIPPDSRRAAeskfltee 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2526794215 231 ----------QALHALCESRGLDpqvgAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19089 240 altpekleqlRKLNKIAAKRGQS----LAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALK 298
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
16-290 |
4.55e-33 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 121.98 E-value: 4.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 16 RIAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCSirlagevsga 95
Cdd:cd19140 10 ALGLGTYPLTG-----EECTRAVEHALELGYRHIDTAQMYGN---EAQVGEAIAASGVPRDELFLTTKVW---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 96 rinHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMD-ADALAAvLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLS 174
Cdd:cd19140 72 ---PDNYSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPlAETLGA-LNEAQEAGLARHIGVSNFTVALLREAVELSE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 175 QPLVANQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRgddgdavrvQQALHALCESRGLDPQvgamQLAV 253
Cdd:cd19140 148 APLFTNQVEYHpYLDQRKL----LDAAREHGIALTAYSPLARGEVLK---------DPVLQEIGRKHGKTPA----QVAL 210
|
250 260 270
....*....|....*....|....*....|....*..
gi 2526794215 254 AWLLKHPaKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19140 211 RWLLQQE-GVAAIPKATNPERLEENLDIFDFTLSDEE 246
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
14-289 |
7.26e-33 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 122.70 E-value: 7.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWrLTDWSYTPRER-LGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRLagev 92
Cdd:cd19074 4 VSELSLGTW-LTFGGQVDDEDaKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWP--RESYVISTKVFWPT---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQ----TDL 168
Cdd:cd19074 77 -GPGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQiaeaHDL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQSRLSQPLVANQIEVSLLQSAPmFDGQLDYCQQHRVMPMAWSPFAGG------------------------RLFRGDDG 224
Cdd:cd19074 156 ARQFGLIPPVVEQPQYNMLWREI-EEEVIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrDKKRRLLT 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2526794215 225 DAVR--VQQaLHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERE 289
Cdd:cd19074 235 DENLekVKK-LKPIADELGLTLA----QLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
10-290 |
9.38e-33 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 122.69 E-value: 9.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTD-----WSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNpVLRERMEIVSKC 84
Cdd:cd19079 8 SGLKVSRLCLGCMSFGDpkwrpWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEF-APRDEVVIATKV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 85 SIRLAGEVSGARinhydTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPH 164
Cdd:cd19079 87 YFPMGDGPNGRG-----LSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYAW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 Q-TDLL----QSRLSQP--------LVANQIEVSLlqsapmfdgqLDYCQQHRVMPMAWSPFAGGRLFR----------- 220
Cdd:cd19079 162 QfAKALhlaeKNGWTKFvsmqnhynLLYREEEREM----------IPLCEEEGIGVIPWSPLARGRLARpwgdtterrrs 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 221 -----------GDDGDAvRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERE 289
Cdd:cd19079 232 ttdtaklkydyFTEADK-EIVDRVEEVAKERGVSMA----QVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEE 306
|
.
gi 2526794215 290 D 290
Cdd:cd19079 307 E 307
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
10-294 |
2.42e-32 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 121.55 E-value: 2.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTdWSYTPR---ERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNpvlRERMEIVSKCSI 86
Cdd:cd19076 8 QGLEVSALGLGCMGMS-AFYGPAdeeESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDR---RDEVVIATKFGI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 RLAGEVSGARINhydTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPhqT 166
Cdd:cd19076 84 VRDPGSGFRGVD---GRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSEASA--D 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 DLLQSRLSQPLVANQIEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRL---------------------FRGDDGD 225
Cdd:cd19076 159 TIRRAHAVHPITAVQSEYSLWTRDIE-DEVLPTCRELGIGFVAYSPLGRGFLtgaikspedlpeddfrrnnprFQGENFD 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 226 A-VRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19076 238 KnLKLVEKLEAIAAEKGCTPA----QLALAWVLAQGDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
13-301 |
7.53e-32 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 119.26 E-value: 7.53e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 13 SLSRIAFGL---WRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirla 89
Cdd:cd19120 3 KIPAIAFGTgtaWYKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYGN---EKEVGEALKESGVPREDLFITTK------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 90 gevsgarinhYDTSATHVRSAVETSLRDMGIEQMDLLLLHRP--DPLMDADaLAAV---LEQLVAEGKVRQLGVSNYLPH 164
Cdd:cd19120 74 ----------VSPGIKDPREALRKSLAKLGVDYVDLYLIHSPffAKEGGPT-LAEAwaeLEALKDAGLVRSIGVSNFRIE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 QTD-LLQSRLSQPLVaNQIEVSllqsaPMFDGQ----LDYCQQHRVMPMAWSPFAGgrLFRGDDGDavrVQQALHALCES 239
Cdd:cd19120 143 DLEeLLDTAKIKPAV-NQIEFH-----PYLYPQqpalLEYCREHGIVVSAYSPLSP--LTRDAGGP---LDPVLEKIAEK 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 240 RGLDPQvgamQLAVAWLLKHpaKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGRGR 301
Cdd:cd19120 212 YGVTPA----QVLLRWALQK--GIVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKAGKQK 267
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
10-290 |
8.25e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 120.46 E-value: 8.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSY----TPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIVSKCS 85
Cdd:cd19149 7 SGIEASVIGLGTWAIGGGPWwggsDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIK---GRRDKVVLATKCG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 86 IRLAGEVS-------GARINHYdTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGV 158
Cdd:cd19149 84 LRWDREGGsfffvrdGVTVYKN-LSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAIGA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 159 SNYLPHQTDllQSRLSQPLVANQIEVSLLQSApMFDGQLDYCQQHRVMPMAWSPFAGG---------RLFRGDDGDAV-- 227
Cdd:cd19149 163 SNVSVEQIK--EYVKAGQLDIIQEKYSMLDRG-IEKELLPYCKKNNIAFQAYSPLEQGlltgkitpdREFDAGDARSGip 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2526794215 228 --------RVQQALHA---LCESRgldpQVGAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19149 240 wfspenreKVLALLEKwkpLCEKY----GCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAED 309
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-294 |
8.94e-32 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 119.70 E-value: 8.94e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRL--TDWSYTP-----RERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIVSKCSi 86
Cdd:cd19102 1 LTTIGLGTWAIggGGWGGGWgpqddRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALK---GLRDRPIVATKCG- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 rLAGEVSGARINHYdtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQt 166
Cdd:cd19102 77 -LLWDEEGRIRRSL--KPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQ- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 dLLQSRLSQPLVANQIEVSLLQSaPMFDGQLDYCQQHRVMPMAWSPFAGG---------RLFRGDDGDAVRVQ------- 230
Cdd:cd19102 153 -MKRCQAIHPIASLQPPYSLLRR-GIEAEILPFCAEHGIGVIVYSPMQSGlltgkmtpeRVASLPADDWRRRSpffqepn 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 231 --QALHALCESRGLDPQVGAM--QLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19102 231 laRNLALVDALRPIAERHGRTvaQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEI 298
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
7-294 |
2.49e-31 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 117.73 E-value: 2.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 7 SLVSDFSLSRIAFGLWRLTDWSYTPRE-----RLGLfeqmlDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIV 81
Cdd:cd19138 4 TLPDGTKVPALGQGTWYMGEDPAKRAQeiealRAGI-----DLGMTLIDTAEMYGDGGSEELVGEAIR---GRRDKVFLV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 82 SKCSIRLAgevsgarinhydtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAvLEQLVAEGKVRQLGVSNY 161
Cdd:cd19138 76 SKVLPSNA-------------SRQGTVRACERSLRRLGTDYLDLYLLHWRGGVPLAETVAA-MEELKKEGKIRAWGVSNF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 162 lphQTDLLQSRLSQP----LVANQIEVSLLQSAPMFDgQLDYCQQHRVMPMAWSPFA-GGRLFRGDDGDAVrvqqaLHAL 236
Cdd:cd19138 142 ---DTDDMEELWAVPgggnCAANQVLYNLGSRGIEYD-LLPWCREHGVPVMAYSPLAqGGLLRRGLLENPT-----LKEI 212
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 237 CESRGLDPQvgamQLAVAWLLKHPAkMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19138 213 AARHGATPA----QVALAWVLRDGN-VIAIPKSGSPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
17-290 |
5.02e-31 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 116.22 E-value: 5.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirlagevsgar 96
Cdd:cd19073 4 LGLGTWQLRG-----DDCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIAESGVPREDLFITTK------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 97 INHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMD-ADALAAvLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQ 175
Cdd:cd19073 63 VWRDHLRPEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPlEETLGA-LKELKEAGKVKSIGVSNFTIELLEEALDISPL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 176 PLVANQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRgddgDAVrvqqaLHALCESRGLDPqvgaMQLAVA 254
Cdd:cd19073 142 PIAVNQVEFHpFLYQAEL----LEYCRENDIVITAYSPLARGEVLR----DPV-----IQEIAEKYDKTP----AQVALR 204
|
250 260 270
....*....|....*....|....*....|....*.
gi 2526794215 255 WLLKHpaKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19073 205 WLVQK--GIVVIPKASSEDHLKENLAIFDWELTSED 238
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
11-290 |
3.26e-30 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 115.87 E-value: 3.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 11 DFSLSRIAFGLWRLTDWSY---TPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVlRERMEIVSKCSIR 87
Cdd:cd19148 1 DLPVSRIALGTWAIGGWMWggtDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGK-RDRVVIATKVGLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 LAGEVSGARinhyDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTD 167
Cdd:cd19148 80 WDEGGEVVR----NSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQME 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 LLqsRLSQPLVANQIEVSLLQSAPMFDgQLDYCQQHRVMPMAWSPFAGGRL---------FRGDDG-------------- 224
Cdd:cd19148 156 TF--RKVAPLHTVQPPYNLFEREIEKD-VLPYARKHNIVTLAYGALCRGLLsgkmtkdtkFEGDDLrrtdpkfqeprfsq 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 225 --DAVrvqQALHALCESRGldpQVGAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19148 233 ylAAV---EELDKLAQERY---GKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLNDED 294
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
13-303 |
5.32e-29 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 112.92 E-value: 5.32e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 13 SLSRIAFGLWRLTDwSYTPR----ERLGLFEQMLDLGVTTFDLADIYGDYrcEQAFGEALKLNPVLRERMEIVSKCSIRL 88
Cdd:cd19144 12 SVPALGFGAMGLSA-FYGPPkpdeERFAVLDAAFELGCTFWDTADIYGDS--EELIGRWFKQNPGKREKIFLATKFGIEK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 AGEvsgARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNylPHQTDL 168
Cdd:cd19144 89 NVE---TGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSE--CSAETL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQSRLSQPLVANQIEVSL----LQSAPMfdGQLDYCQQHRVMPMAWSP----FAGGRLFRGDD---GD----AVRVQQ-- 231
Cdd:cd19144 164 RRAHAVHPIAAVQIEYSPfsldIERPEI--GVLDTCRELGVAIVAYSPlgrgFLTGAIRSPDDfeeGDfrrmAPRFQAen 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 232 ---------ALHALCESRGldpqVGAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGRGRE 302
Cdd:cd19144 242 fpknlelvdKIKAIAKKKN----VTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIREIAEEAE 317
|
.
gi 2526794215 303 V 303
Cdd:cd19144 318 V 318
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
37-290 |
3.98e-28 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 110.20 E-value: 3.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 37 LFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnPVLRERMEIVSKCSIRLAGEVSGarinhYDTSATHVRSAVETSLR 116
Cdd:cd19083 38 LVREALDNGVNLLDTAFIYGLGRSEELVGEVLK--EYNRNEVVIATKGAHKFGGDGSV-----LNNSPEFLRSAVEKSLK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 117 DMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQtdLLQSRLSQPLVANQIEVSLLQSApMFDGQ 196
Cdd:cd19083 111 RLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLEQ--LKEANKDGYVDVLQGEYNLLQRE-AEEDI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 197 LDYCQQHRVMPMAWSPFAGGRL-------FRGDDGD---------AVRVQQALHA------LCESRGLDPQvgamQLAVA 254
Cdd:cd19083 188 LPYCVENNISFIPYFPLASGLLagkytkdTKFPDNDlrndkplfkGERFSENLDKvdklksIADEKGVTVA----HLALA 263
|
250 260 270
....*....|....*....|....*....|....*.
gi 2526794215 255 WLLKHPAKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19083 264 WYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEE 299
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
13-290 |
1.60e-27 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 107.36 E-value: 1.60e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 13 SLSRIAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirLAGev 92
Cdd:cd19132 6 QIPAIGFGTYPLKG-----DEGVEAVVAALQAGYRLLDTAFNYEN---EGAVGEAVRRSGVPREELFVTTK----LPG-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sgaRINHYDTsathVRSAVETSLRDMGIEQMDLLLLHRPDPLMD--ADALAAVLEqLVAEGKVRQLGVSNYLPHQTDLLQ 170
Cdd:cd19132 72 ---RHHGYEE----ALRTIEESLYRLGLDYVDLYLIHWPNPSRDlyVEAWQALIE-AREEGLVRSIGVSNFLPEHLDRLI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 171 SRLSQPLVANQIEVSllqsaPMF--DGQLDYCQQHRVMPMAWSPFagGRlfrgddGDAVRVQQALHALCESRGLDPQvga 248
Cdd:cd19132 144 DETGVTPAVNQIELH-----PYFpqAEQRAYHREHGIVTQSWSPL--GR------GSGLLDEPVIKAIAEKHGKTPA--- 207
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 249 mQLAVAWLLKHPAkmVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19132 208 -QVVLRWHVQLGV--VPIPKSANPERQRENLAIFDFELSDED 246
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
8-294 |
7.63e-27 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 106.93 E-value: 7.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 8 LVSDFSLSRIAFG---LWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNpvlRERMEIVSKC 84
Cdd:cd19091 12 KVSELALGTMTFGgggGFFGAWGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR---RDDVLIATKV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 85 SIRLagevsGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPH 164
Cdd:cd19091 89 RGRM-----GEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVSNFSAW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 QTDLLQS----RLSQPLVANQIEVSLLQSapmfdgqlDYcqQHRVMPMA---------WSPFAGGRL------------- 218
Cdd:cd19091 164 QIMKALGiserRGLARFVALQAYYSLLGR--------DL--EHELMPLAldqgvgllvWSPLAGGLLsgkyrrgqpapeg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 219 --FRGDDGDAVRVQQ--------ALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMER 288
Cdd:cd19091 234 srLRRTGFDFPPVDRergydvvdALREIAKETGATPA----QVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLSLTP 309
|
....*.
gi 2526794215 289 EDWYEL 294
Cdd:cd19091 310 EEIARL 315
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
9-289 |
8.07e-26 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 103.84 E-value: 8.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 9 VSDFSLSRIAFGlwrlTDWSY--TPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNpvlRERMEIVSKCSI 86
Cdd:cd19080 10 VSPLALGTMTFG----TEWGWgaDREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN---RDRIVLATKYTM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 RLAGEVSGARINHydtsATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSN----YL 162
Cdd:cd19080 83 NRRPGDPNAGGNH----RKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDtpawVV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 163 PHQTDLLQSRLSQPLVANQIEVSLLQSAPMFDgQLDYCQQHRVMPMAWSPFAGGRL-------FRGDDGDAVRVQQALHA 235
Cdd:cd19080 159 ARANTLAELRGWSPFVALQIEYSLLERTPERE-LLPMARALGLGVTPWSPLGGGLLtgkyqrgEEGRAGEAKGVTVGFGK 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2526794215 236 LCES--------RGLDPQVG--AMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERE 289
Cdd:cd19080 238 LTERnwaivdvvAAVAEELGrsAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPE 301
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
10-294 |
2.51e-25 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 102.68 E-value: 2.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLtDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDY-------RCEQAFGEALKLNpVLRERMEIVS 82
Cdd:cd19081 5 TGLSVSPLCLGTMVF-GWTADEETSFALLDAFVDAGGNFIDTADVYSAWvpgnaggESETIIGRWLKSR-GKRDRVVIAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 83 KcsIRlagevSGARINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYL 162
Cdd:cd19081 83 K--VG-----FPMGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 163 PHQT----DLLQSRLSQPLVANQIEVSLLQSAPmFDGQL-DYCQQHRVMPMAWSPFAGGRL---FRGDD--------GDA 226
Cdd:cd19081 156 AWRLqealELSRQHGLPRYVSLQPEYNLVDRES-FEGELlPLCREEGIGVIPYSPLAGGFLtgkYRSEAdlpgstrrGEA 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2526794215 227 V---------RVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19081 235 AkrylnerglRILDALDEVAAEHGATPA----QVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEVARL 307
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
42-281 |
2.63e-25 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 101.86 E-value: 2.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrCEQAFGEALKLNPvlRERMEIVSKCSIRLAGevsgarinHYDTSATHVRSAVETSLRDMGIE 121
Cdd:cd19090 30 LDLGINYIDTAPAYGD--SEERLGLALAELP--REPLVLSTKVGRLPED--------TADYSADRVRRSVEESLERLGRD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 122 QMDLLLLHRPD--PLMDADALAAVLEQLV---AEGKVRQLGVS-NYLPHQTDLLQS-RLSQPLVANQIevSLL-QSApmF 193
Cdd:cd19090 98 RIDLLMIHDPErvPWVDILAPGGALEALLelkEEGLIKHIGLGgGPPDLLRRAIETgDFDVVLTANRY--TLLdQSA--A 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 194 DGQLDYCQQHRVMPMAWSPFAGGRLFRGDD---------GDAVRVQQA--LHALCESRGLDpqvgAMQLAVAWLLKHPAK 262
Cdd:cd19090 174 DELLPAAARHGVGVINASPLGMGLLAGRPPervrytyrwLSPELLDRAkrLYELCDEHGVP----LPALALRFLLRDPRI 249
|
250
....*....|....*....
gi 2526794215 263 MVPVLGSGNPERLVAALAA 281
Cdd:cd19090 250 STVLVGASSPEELEQNVAA 268
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-282 |
6.41e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 97.66 E-value: 6.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLwrltdwSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRLAGevs 93
Cdd:cd19105 13 VSRLGFGG------GGLPRESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGLR--RDKVFLATKASPRLDK--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 94 garinhydTSATHVRSAVETSLRDMGIEQMDLLLLHR---PDPLMDADALAAVLEQLVAEGKVRQLGVSNylpH--QTDL 168
Cdd:cd19105 82 --------KDKAELLKSVEESLKRLQTDYIDIYQLHGvdtPEERLLNEELLEALEKLKKEGKVRFIGFST---HdnMAEV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 169 LQsRLSQPLVANQIEVS---LLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDAvrvqqalhalcESRGLDPq 245
Cdd:cd19105 151 LQ-AAIESGWFDVIMVAynfLNQPAEL-EEALAAAAEKGIGVVAMKTLAGGYLQPALLSVL-----------KAKGFSL- 216
|
250 260 270
....*....|....*....|....*....|....*..
gi 2526794215 246 vgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAAL 282
Cdd:cd19105 217 ---PQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
10-284 |
1.81e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 97.72 E-value: 1.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFG------LWRLTdwsyTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKlnpVLRERMEIVSK 83
Cdd:cd19104 8 TGLKVSELTFGgggiggLMGRT----TREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALK---GLPAGPYITTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 84 CSIRLAGEvsgarinhyDTSATHVRSAVETSLRDMGIEQMDLLLLH------RPDPL---------MDADALAAVLEQLV 148
Cdd:cd19104 81 VRLDPDDL---------GDIGGQIERSVEKSLKRLKRDSVDLLQLHnrigdeRDKPVggtlsttdvLGLGGVADAFERLR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 149 AEGKVRQLGVSNyLPHQTDLLQSRLSQPLVANQIEVSLLQSA------PMFDGQ-----LDYCQQHRVMPMAWSPFAGGR 217
Cdd:cd19104 152 SEGKIRFIGITG-LGNPPAIRELLDSGKFDAVQVYYNLLNPSaaearpRGWSAQdyggiIDAAAEHGVGVMGIRVLAAGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 218 L-------------FRGDDGDAVRVQQALHALCESRGLDPQvgamQLAVAWLLKHPakMVP--VLGSGNPERLVAALAAL 282
Cdd:cd19104 231 LttsldrgreapptSDSDVAIDFRRAAAFRALAREWGETLA----QLAHRFALSNP--GVStvLVGVKNREELEEAVAAE 304
|
..
gi 2526794215 283 DM 284
Cdd:cd19104 305 AA 306
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
36-283 |
7.33e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 95.48 E-value: 7.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 36 GLFEQMLDLGVTTFDLADIYGDY-------RCEQAFGEALKLNPVlRERMEIVSKCSIRLaGEVSGARINHYDTSATHVR 108
Cdd:cd19752 21 AILDRYVAAGGNFLDTANNYAFWteggvggESERLIGRWLKDRGN-RDDVVIATKVGAGP-RDPDGGPESPEGLSAETIE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 109 SAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNY----LPHQTDLLQSRLSQPLVANQIEV 184
Cdd:cd19752 99 QEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFaawrLERARQIARQQGWAEFSAIQQRH 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 185 SLLQSAPM--FDGQ-------LDYCQQHRVMP-MAWSPFAGGRLFRGD-------DG-DAVRVQQALHALCESRGldpqV 246
Cdd:cd19752 179 SYLRPRPGadFGVQrivtdelLDYASSRPDLTlLAYSPLLSGAYTRPDrplpeqyDGpDSDARLAVLEEVAGELG----A 254
|
250 260 270
....*....|....*....|....*....|....*..
gi 2526794215 247 GAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19752 255 TPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
16-290 |
1.40e-22 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 94.51 E-value: 1.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 16 RIAFGLWRLTdwsytPRERLGLFEQMLDLGVTTFDLADIYGDYR-CEQAFGEALKLNPVLRERMEIVSKcsirlagevsg 94
Cdd:cd19128 3 RLGFGTYKIT-----ESESKEAVKNAIKAGYRHIDCAYYYGNEAfIGIAFSEIFKDGGVKREDLFITSK----------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 95 arINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRP---DPLMDADALAA----------------VLEQLVAEGKVRQ 155
Cdd:cd19128 67 --LWPTMHQPENVKEQLLITLQDLQLEYLDLFLIHWPlafDMDTDGDPRDDnqiqslskkpledtwrAMEQCVDEKLTKN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 156 LGVSNY-LPHQTDLLQSRLSQPLVaNQIEVSllqsaPMF--DGQLDYCQQHRVMPMAWSPFaGGRlfRGDDGDAVRVQQA 232
Cdd:cd19128 145 IGVSNYsTKLLTDLLNYCKIKPFM-NQIECH-----PYFqnDKLIKFCIENNIHVTAYRPL-GGS--YGDGNLTFLNDSE 215
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2526794215 233 LHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVL-GSGNPERLVAALAALDMEMERED 290
Cdd:cd19128 216 LKALATKYNTTPP----QVIIAWHLQKWPKNYSVIpKSANKSRCQQNFDINDLALTKED 270
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
42-290 |
2.37e-22 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 93.61 E-value: 2.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirlageVSGARINhYDTSAthvrSAVETSLRDMGIE 121
Cdd:cd19157 34 LKNGYRSIDTAAIYGN---EEGVGKGIKESGIPREELFITSK--------VWNADQG-YDSTL----KAFEASLERLGLD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 122 QMDLLLLHRPDPLMDADALAAvLEQLVAEGKVRQLGVSNYLPHQ-TDLLQSRLSQPLVaNQIEVSllqsaPMFDGQ--LD 198
Cdd:cd19157 98 YLDLYLIHWPVKGKYKETWKA-LEKLYKDGRVRAIGVSNFQVHHlEDLLADAEIVPMV-NQVEFH-----PRLTQKelRD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 199 YCQQHRVMPMAWSPFAGGRLFRGDdgdavrvqqALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAA 278
Cdd:cd19157 171 YCKKQGIQLEAWSPLMQGQLLDNP---------VLKEIAEKYNKSVA----QVILRWDLQNGVVTIP--KSIKEHRIIEN 235
|
250
....*....|..
gi 2526794215 279 LAALDMEMERED 290
Cdd:cd19157 236 ADVFDFELSQED 247
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
12-294 |
2.66e-22 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 94.42 E-value: 2.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 12 FSLSRIAFGLWRLTDWSYTPR---ERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRL 88
Cdd:cd19145 10 LEVSAQGLGCMGLSGDYGAPKpeeEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGP--REKVQLATKFGIHE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 AG----EVSGarinhydtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPh 164
Cdd:cd19145 88 IGgsgvEVRG--------DPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASA- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 qTDLLQSRLSQPLVANQIEVSLLqSAPMFDGQLDYCQQHRVMPMAWSP-----FAGG-RLFRGDDGDAVR---------- 228
Cdd:cd19145 159 -DTIRRAHAVHPITAVQLEWSLW-TRDIEEEIIPTCRELGIGIVPYSPlgrgfFAGKaKLEELLENSDVRkshprfqgen 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 229 ------VQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19145 237 leknkvLYERVEALAKKKGCTPA----QLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
10-283 |
2.87e-22 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 94.39 E-value: 2.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRltdwSYTPRERLGLFEQML----DLGVTTFDLADIYGDY--RCEQAFGEALK--LNPvLRERMEIV 81
Cdd:cd19151 8 SGLKLPAISLGLWH----NFGDVDRYENSRAMLrrafDLGITHFDLANNYGPPpgSAEENFGRILKedLKP-YRDELIIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 82 SKcsirlAGEV--SGARINHydTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVS 159
Cdd:cd19151 83 TK-----AGYTmwPGPYGDW--GSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGIS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 160 NYLPHQT----DLLQsRLSQPLVANQIEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRL----FRGDDGDAvRVQQ 231
Cdd:cd19151 156 NYPPEEAreaaAILK-DLGTPCLIHQPKYSMFNRWVE-EGLLDVLEEEGIGCIAFSPLAQGLLtdryLNGIPEDS-RAAK 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 232 A-------------------LHALCESRGldpQVGAmQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19151 233 GssflkpeqiteeklakvrrLNEIAQARG---QKLA-QMALAWVLRNKRVTSVLIGASKPSQIEDAVGALD 299
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
17-301 |
3.35e-22 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 94.01 E-value: 3.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRltdwsYTPRERLGLFEQMLDLGVTTFDLADIYGDyRCE--QAFGEALKLNPVLRERMEIVSK--CSirlagev 92
Cdd:cd19123 15 LGLGTWK-----SKPGEVGQAVKQALEAGYRHIDCAAIYGN-EAEigAALAEVFKEGKVKREDLWITSKlwNN------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sgarinhyDTSATHVRSAVETSLRDMGIEQMDLLLLHRP-------------------DPLMDADALAAvLEQLVAEGKV 153
Cdd:cd19123 82 --------SHAPEDVLPALEKTLADLQLDYLDLYLMHWPvalkkgvgfpesgedllslSPIPLEDTWRA-MEELVDKGLC 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 154 RQLGVSNYLPHQTDLLQSRLSQPLVANQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGG---RLFRGDDGDAVRV 229
Cdd:cd19123 153 RHIGVSNFSVKKLEDLLATARIKPAVNQVELHpYLQQPEL----LAFCRDNGIHLTAYSPLGSGdrpAAMKAEGEPVLLE 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 230 QQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMEREDWYELLRAGRGR 301
Cdd:cd19123 229 DPVINKIAEKHGASPA----QVLIAWAIQRGTVVIP--KSVNPERIQQNLEAAEVELDASDMATIAALDRHH 294
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
19-290 |
4.54e-22 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 92.64 E-value: 4.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 19 FGLWRLTDWSYTPRERLglfeQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCSIRlagevsgarin 98
Cdd:cd19133 14 FGVFQIPDPEECERAVL----EAIKAGYRLIDTAAAYGN---EEAVGRAIKKSGIPREELFITTKLWIQ----------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 99 hyDTSATHVRSAVETSLRDMGIEQMDLLLLHRPdplmDADALAA--VLEQLVAEGKVRQLGVSNYLPHQ-TDLLQSRLSQ 175
Cdd:cd19133 76 --DAGYEKAKKAFERSLKRLGLDYLDLYLIHQP----FGDVYGAwrAMEELYKEGKIRAIGVSNFYPDRlVDLILHNEVK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 176 PLVaNQIEVSllqsaPMF--DGQLDYCQQHRVMPMAWSPFAGGR--LFRGDdgdavrvqqALHALCESRGLDpqvgAMQL 251
Cdd:cd19133 150 PAV-NQIETH-----PFNqqIEAVEFLKKYGVQIEAWGPFAEGRnnLFENP---------VLTEIAEKYGKS----VAQV 210
|
250 260 270
....*....|....*....|....*....|....*....
gi 2526794215 252 AVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19133 211 ILRWLIQRGIVVIP--KSVRPERIAENFDIFDFELSDED 247
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-290 |
1.14e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 92.66 E-value: 1.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 13 SLSRIAFGLWRLTD-WSYTPRERLGL--FEQMLDLGVTTFDLADIYGdyRCEQAFGEALKL---NPVLRERMEIVSKCSI 86
Cdd:cd19101 1 TISRVINGMWQLSGgHGGIRDEDAAVraMAAYVDAGLTTFDCADIYG--PAEELIGEFRKRlrrERDAADDVQIHTKWVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 rlagevsgaRINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDA--DALAAvLEQLVAEGKVRQLGVSNY-LP 163
Cdd:cd19101 79 ---------DPGELTMTRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPGylDAAKH-LAELQEEGKIRHLGLTNFdTE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 164 HQTDLLQSRLsqPLVANQIEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRL---FRG-DDGDAVR----------- 228
Cdd:cd19101 149 RLREILDAGV--PIVSNQVQYSLLDRRPE-NGMAALCEDHGIKLLAYGTLAGGLLsekYLGvPEPTGPAletrslqkykl 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 229 ---------VQQALHALCESRGLDPQVGAMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19101 226 midewggwdLFQELLRTLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDED 296
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
16-290 |
2.95e-21 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 90.65 E-value: 2.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 16 RIAFGLWRLTDWSytprERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirLAGEVSGa 95
Cdd:cd19156 11 RLGLGVWRVQDGA----EAENAVKWAIEAGYRHIDTAAIYKN---EEGVGQGIRESGVPREEVFVTTK----LWNSDQG- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 96 rinhYDTSAthvrSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAvLEQLVAEGKVRQLGVSNYLPHQ-TDLLQSRLS 174
Cdd:cd19156 79 ----YESTL----AAFEESLEKLGLDYVDLYLIHWPVKGKFKDTWKA-FEKLYKEKKVRAIGVSNFHEHHlEELLKSCKV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 175 QPLVaNQIEV-SLLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRgddgdavrvQQALHALCESRGLDpqvgAMQLAV 253
Cdd:cd19156 150 APMV-NQIELhPLLTQEPL----RKFCKEKNIAVEAWSPLGQGKLLS---------NPVLKAIGKKYGKS----AAQVII 211
|
250 260 270
....*....|....*....|....*....|....*..
gi 2526794215 254 AWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19156 212 RWDIQHGIITIP--KSVHEERIQENFDVFDFELTAEE 246
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
14-290 |
4.36e-21 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 89.72 E-value: 4.36e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRLTDWSYTPRERLGLfeqmlDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirlagevs 93
Cdd:cd19139 1 IPAFGLGTFRLKDDVVIDSVRTAL-----ELGYRHIDTAQIYDN---EAAVGQAIAESGVPRDELFITTK---------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 94 gARINHYDTSAthVRSAVETSLRDMGIEQMDLLLLHRPDPlMDADALAAVLEQL---VAEGKVRQLGVSNYLPHQTDLLQ 170
Cdd:cd19139 63 -IWIDNLSKDK--LLPSLEESLEKLRTDYVDLTLIHWPSP-NDEVPVEEYIGALaeaKEQGLTRHIGVSNFTIALLDEAI 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 171 SRL-SQPLVANQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLfrGDDgdavrvqQALHALCESRGLDPQvga 248
Cdd:cd19139 139 AVVgAGAIATNQIELSpYLQNRKL----VAHCKQHGIHVTSYMTLAYGKV--LDD-------PVLAAIAERHGATPA--- 202
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 249 mQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19139 203 -QIALAWAMARGYAVIP--SSTKREHLRSNLLALDLTLDADD 241
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
27-290 |
1.01e-20 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 88.97 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 27 WSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirLAGEVSGarinhYDTSath 106
Cdd:cd19131 18 WQVSNDEAASAVREALEVGYRSIDTAAIYGN---EEGVGKAIRASGVPREELFITTK----LWNSDQG-----YDST--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 107 vRSAVETSLRDMGIEQMDLLLLHRPDPLMD--ADALAAvLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQPLVANQIEV 184
Cdd:cd19131 83 -LRAFDESLRKLGLDYVDLYLIHWPVPAQDkyVETWKA-LIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 185 -SLLQSApmfdgQL-DYCQQHRVMPMAWSPFAGGRLFRgddgdavrvQQALHALCESRGLDPQvgamQLAVAWLLKHPAK 262
Cdd:cd19131 161 hPRFQQR-----ELrAFHAKHGIQTESWSPLGQGGLLS---------DPVIGEIAEKHGKTPA----QVVIRWHLQNGLV 222
|
250 260
....*....|....*....|....*...
gi 2526794215 263 MVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19131 223 VIP--KSVTPSRIAENFDVFDFELDADD 248
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
58-218 |
4.07e-20 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 87.76 E-value: 4.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 58 YRCEQAFGEALKLNPVLRERMEIVSKCSIrlagevsgariNHYDTSAThvRSAVETSLRDMGIEQMDLLLLHRPDPLMDA 137
Cdd:cd19135 49 YGCEELLGKAIKESGVPREDLFLTTKLWP-----------SDYGYEST--KQAFEASLKRLGVDYLDLYLLHWPDCPSSG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 138 D----ALAAV---LEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQPLVANQIEVSLLQSaPMfdgQL-DYCQQHRVMPMA 209
Cdd:cd19135 116 KnvkeTRAETwraLEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQN-PV---ELiEYCRDNNIVFEG 191
|
....*....
gi 2526794215 210 WSPFAGGRL 218
Cdd:cd19135 192 YCPLAKGKA 200
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
13-290 |
5.01e-20 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 87.27 E-value: 5.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 13 SLSRIAFGLWRLTDwSYTPRerlgLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsirlagev 92
Cdd:cd19130 9 SIPQLGYGVFKVPP-ADTQR----AVATALEVGYRHIDTAAIYGN---EEGVGAAIAASGIPRDELFVTTK--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sgarINHYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALA-AVLEQLVAEGKVRQLGVSNYLP-HQTDLLQ 170
Cdd:cd19130 72 ----LWNDRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPTPAAGNYVHTwEAMIELRAAGRTRSIGVSNFLPpHLERIVA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 171 SRLSQPLVaNQIEVSllqsaPMFDGQL--DYCQQHRVMPMAWSPFAGGRLFrgdDGDAVRVQQALHalcesrGLDPQvga 248
Cdd:cd19130 148 ATGVVPAV-NQIELH-----PAYQQRTirDWAQAHDVKIEAWSPLGQGKLL---GDPPVGAIAAAH------GKTPA--- 209
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 249 mQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19130 210 -QIVLRWHLQKGHVVFP--KSVRRERMEDNLDVFDFDLTDTE 248
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
17-290 |
7.62e-20 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 86.92 E-value: 7.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRLTDwsytPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALK-LNP---VLRERMEIVSKCSIRLAGEV 92
Cdd:cd19136 4 LGLGTFRLRG----EEEVRQAVDAALKAGYRLIDTASVYRN---EADIGKALRdLLPkygLSREDIFITSKLAPKDQGYE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 SgarinhydtsathVRSAVETSLRDMGIEQMDLLLLH-------RPDPLMDADALAA---VLEQLVAEGKVRQLGVSNYL 162
Cdd:cd19136 77 K-------------ARAACLGSLERLGTDYLDLYLIHwpgvqglKPSDPRNAELRREswrALEDLYKEGKLRAIGVSNYT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 163 P-HQTDLLQSRLSQPLVaNQIEVS--LLQSApmfdgQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDAVRVQQALhalces 239
Cdd:cd19136 144 VrHLEELLKYCEVPPAV-NQVEFHphLVQKE-----LLKFCKDHGIHLQAYSSLGSGDLRLLEDPTVLAIAKKY------ 211
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 240 rgldpQVGAMQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19136 212 -----GRTPAQVLLRWALQQGIGVIP--KSTNPERIAENIKVFDFELSEED 255
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
51-290 |
2.12e-19 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 85.54 E-value: 2.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 51 LADIYGDYRCEQAFGEALKLNPVLRERMEIVSKCSIRLAGevsgarinhYDTSathvRSAVETSLRDMGIEQMDLLLLHR 130
Cdd:cd19127 38 LIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYG---------YDKA----LRGFDASLRRLGLDYVDLYLLHW 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 131 PDPLMDADALAA--VLEQLVAEGKVRQLGVSNYLP-HQTDLLQSRLSQPLVaNQIEVSllqsaPMFDGQ--LDYCQQHRV 205
Cdd:cd19127 105 PVPNDFDRTIQAykALEKLLAEGRVRAIGVSNFTPeHLERLIDATTVVPAV-NQVELH-----PYFSQKdlRAFHRRLGI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 206 MPMAWSPFAGGRLFRGDDGDA---VRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAAL 282
Cdd:cd19127 179 VTQAWSPIGGVMRYGASGPTGpgdVLQDPTITGLAEKYGKTPA----QIVLRWHLQNGVSAIP--KSVHPERIAENIDIF 252
|
....*...
gi 2526794215 283 DMEMERED 290
Cdd:cd19127 253 DFALSAED 260
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
19-290 |
4.79e-19 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 84.41 E-value: 4.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 19 FGLWRLTDWSYTPRERLglfeQMLDLGVTTFDLADIYgdyRCEQAFGEALKLNPVLRERMEIVSKcsirlagevsgarIN 98
Cdd:cd19126 14 LGVFQTPDGDETERAVQ----TALENGYRSIDTAAIY---KNEEGVGEAIRESGVPREELFVTTK-------------LW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 99 HYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAvLEQLVAEGKVRQLGVSNYLPHQTD-LLQSRLSQPL 177
Cdd:cd19126 74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKDKFIDTWKA-LEKLYASGKVKAIGVSNFQEHHLEeLLAHADVVPA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 178 VaNQIEVSllqsaPMFDGQ--LDYCQQHRVMPMAWSPFAGGRLFRgddgDAVrvqqaLHALCESRGLDPQvgamQLAVAW 255
Cdd:cd19126 153 V-NQVEFH-----PYLTQKelRGYCKSKGIVVEAWSPLGQGGLLS----NPV-----LAAIGEKYGKSAA----QVVLRW 213
|
250 260 270
....*....|....*....|....*....|....*
gi 2526794215 256 LLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19126 214 DIQHGVVTIP--KSVHASRIKENADIFDFELSEDD 246
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-280 |
8.32e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 83.30 E-value: 8.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 14 LSRIAFGLWRLtdWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrCEQAFGEALKLNpvlRERMEIVSKcsirlagevS 93
Cdd:cd19100 11 VSRLGFGGGPL--GRLSQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGR---RDKVFLATK---------T 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 94 GARinhydtSATHVRSAVETSLRDMGIEQMDLLLLH------------RPDPLMDAdalaavLEQLVAEGKVRQLGVSNy 161
Cdd:cd19100 75 GAR------DYEGAKRDLERSLKRLGTDYIDLYQLHavdteedldqvfGPGGALEA------LLEAKEEGKIRFIGISG- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 162 lpHQTDLLQSRLSQPLV-ANQIEVSLL--QSAPMFDGQLDYCQQHRVMPMAWSPFAGGRLFrgdDGDAVRVQQALHalce 238
Cdd:cd19100 142 --HSPEVLLRALETGEFdVVLFPINPAgdHIDSFREELLPLAREKGVGVIAMKVLAGGRLL---SGDPLDPEQALR---- 212
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 239 srgldpqvgamqlavaWLLKHPAKMVPVLGSGNPERLVAALA 280
Cdd:cd19100 213 ----------------YALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
42-283 |
1.73e-18 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 83.75 E-value: 1.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCsirlaGEVSGARINHYDTSATHVRSAVETSLRDMGIE 121
Cdd:cd19163 43 LDSGINYIDTAPWYGQGRSETVLGKALKGIP--RDSYYLATKV-----GRYGLDPDKMFDFSAERITKSVEESLKRLGLD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 122 QMDLLLLHRPD--PLMD---ADALAAvLEQLVAEGKVRQLGVSNYlPhqTDLLQSRLSQplVANQIEVSLL--------Q 188
Cdd:cd19163 116 YIDIIQVHDIEfaPSLDqilNETLPA-LQKLKEEGKVRFIGITGY-P--LDVLKEVLER--SPVKIDTVLSychytlndT 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 189 SAPMFdgqLDYCQQHRVMPMAWSPFAGGRLfrGDDG---------DAVRVQQALHALCESRGLDpqvgAMQLAVAWLLKH 259
Cdd:cd19163 190 SLLEL---LPFFKEKGVGVINASPLSMGLL--TERGppdwhpaspEIKEACAKAAAYCKSRGVD----ISKLALQFALSN 260
|
250 260
....*....|....*....|....
gi 2526794215 260 PAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19163 261 PDIATTLVGTASPENLRKNLEAAE 284
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
10-283 |
1.82e-18 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 84.27 E-value: 1.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDY--RCEQAFGEALKLN-PVLRERMEIVSKCSI 86
Cdd:PRK09912 21 SGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPpgSAEENFGRLLREDfAAYRDELIISTKAGY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 87 RLAGEVSGArinhyDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQT 166
Cdd:PRK09912 101 DMWPGPYGS-----GGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 DLLQSRLSQ---PLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFA--------------GGRLFRgdDGDAVR- 228
Cdd:PRK09912 176 QKMVELLREwkiPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAqglltgkylngipqDSRMHR--EGNKVRg 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2526794215 229 -----VQQA-------LHALCESRGldpQVGAmQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:PRK09912 254 ltpkmLTEAnlnslrlLNEMAQQRG---QSMA-QMALSWLLKDERVTSVLIGASRAEQLEENVQALN 316
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-294 |
7.24e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 82.00 E-value: 7.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 38 FEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRLAGevsgarinhydTSATHVRSAVETSLRD 117
Cdd:cd19103 38 FDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYP--REDYIISTKFTPQIAG-----------QSADPVADMLEGSLAR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 118 MGIEQMDLLLLHRPdplMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQ---PLVANQIEVSLLQSAPMFD 194
Cdd:cd19103 105 LGTDYIDIYWIHNP---ADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKagvSLSAVQNHYSLLYRSSEEA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 195 GQLDYCQQHRVMPMAWSPFAGGRL---------FRGDDGDAV---RVQQALHAL---CESRGLDPQVGAMQLAVAWLLkh 259
Cdd:cd19103 182 GILDYCKENGITFFAYMVLEQGALsgkydtkhpLPEGSGRAEtynPLLPQLEELtavMAEIGAKHGASIAQVAIAWAI-- 259
|
250 260 270
....*....|....*....|....*....|....*.
gi 2526794215 260 pAK-MVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19103 260 -AKgTTPIIGVTKPHHVEDAARAASITLTDDEIKEL 294
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
38-294 |
7.51e-18 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 81.64 E-value: 7.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 38 FEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRL---AGEVSGARINHYDTSATHVRSAVETS 114
Cdd:cd19162 25 LDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHP--RAEYVVSTKVGRLLepgAAGRPAGADRRFDFSADGIRRSIEAS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 115 LRDMGIEQMDLLLLHRPDPLMDA---DALAAvLEQLVAEGKVRQLGV-SNYLPHQTDLLQ-SRLSQPLVANqiEVSLLQS 189
Cdd:cd19162 103 LERLGLDRLDLVFLHDPDRHLLQaltDAFPA-LEELRAEGVVGAIGVgVTDWAALLRAARrADVDVVMVAG--RYTLLDR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 190 APMfDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDGDA-----------VRVQQALHALCESRGldpqVGAMQLAVAWLLK 258
Cdd:cd19162 180 RAA-TELLPLCAAKGVAVVAAGVFNSGILATDDPAGDrydyrpatpevLARARRLAAVCRRYG----VPLPAAALQFPLR 254
|
250 260 270
....*....|....*....|....*....|....*.
gi 2526794215 259 HPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19162 255 HPAVASVVVGAASPAELRDNLALLRTPIPAEFWAEL 290
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
17-294 |
8.88e-18 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 81.56 E-value: 8.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRLTDwsytPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEAL----KLNPVLRERMEIVSKCSIrlagev 92
Cdd:cd19116 14 IALGTWKLKD----DEGVRQAVKHAIEAGYRHIDTAYLYGN---EAEVGEAIrekiAEGVVKREDLFITTKLWN------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sgarINHydtSATHVRSAVETSLRDMGIEQMDLLLLHRP--------------DPLMDADALAA--VLEQLVAEGKVRQL 156
Cdd:cd19116 81 ----SYH---EREQVEPALRESLKRLGLDYVDLYLIHWPvafkenndsesngdGSLSDIDYLETwrGMEDLVKLGLTRSI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 157 GVSNYLPHQTDLLQSRLSQPLVANQIEVSL-LQSAPMFdgqlDYCQQHRVMPMAWSPFagGRLF-RGDDGDAVRVQ-QAL 233
Cdd:cd19116 154 GVSNFNSEQINRLLSNCNIKPAVNQIEVHPtLTQEKLV----AYCQSNGIVVMAYSPF--GRLVpRGQTNPPPRLDdPTL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 234 HALCESRGLDPQvgamQLAVAWLLKHpaKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19116 228 VAIAKKYGKTTA----QIVLRYLIDR--GVVPIPKSSNKKRIKENIDIFDFQLTPEEVAAL 282
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-280 |
9.47e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 81.98 E-value: 9.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 12 FSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALK----LNPVLRERMEIVSK---- 83
Cdd:cd19099 1 LTLSSLGLGTYRGDSDDETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRelieKGGIKRDEVVIVTKagyi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 84 ---------------CSIRLAGEVSGARINH-YDTSATHVRSAVETSLRDMGIEQMDLLLLHRP---------DPLMDAD 138
Cdd:cd19099 81 pgdgdeplrplkyleEKLGRGLIDVADSAGLrHCISPAYLEDQIERSLKRLGLDTIDLYLLHNPeeqllelgeEEFYDRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 139 ALA-AVLEQLVAEGKVRQLGVSNYLPHQ--TDLLQSRLSQPLVAN--------------QIEVSLLQSAPMFDGQ----- 196
Cdd:cd19099 161 EEAfEALEEAVAEGKIRYYGISTWDGFRapPALPGHLSLEKLVAAaeevggdnhhfkviQLPLNLLEPEALTEKNtvkge 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 197 ----LDYCQQHRVMPMAWSPFAGGRLFRGDdgdavrvqqalhALCESRGLDPQVGAMQLAVAWLLKHPAKMVPVLGSGNP 272
Cdd:cd19099 241 alslLEAAKELGLGVIASRPLNQGQLLGEL------------RLADLLALPGGATLAQRALQFARSTPGVDSALVGMRRP 308
|
....*...
gi 2526794215 273 ERLVAALA 280
Cdd:cd19099 309 EHVDENLA 316
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
10-283 |
1.89e-17 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 80.96 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDY--RCEQAFGEALK--LNPvLRERMEIVSKCS 85
Cdd:cd19150 8 SGLKLPALSLGLWHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGPPpgSAEENFGRILRedFAG-YRDELIISTKAG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 86 IRL----AGEvSGARinhydtsaTHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNY 161
Cdd:cd19150 87 YDMwpgpYGE-WGSR--------KYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 162 LPHQT----DLLQsRLSQPLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRL------------------- 218
Cdd:cd19150 158 SPERTreaaAILR-ELGTPLLIHQPSYNMLNRWVEESGLLDTLQELGVGCIAFTPLAQGLLtdkylngipegsraskers 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2526794215 219 FRGDD--GDAVRVQQALHALCESRGldpQVGAmQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19150 237 LSPKMltEANLNSIRALNEIAQKRG---QSLA-QMALAWVLRDGRVTSALIGASRPEQLEENVGALD 299
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
7-290 |
2.81e-17 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 80.61 E-value: 2.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 7 SLVSDFSLSRIAFGLWRLTdwsytPRERLGLFEQMLDLGVTTFDLAdiyGDYRCEQAFGEALKL----NPVLRERMEIVS 82
Cdd:cd19112 4 TLNSGHKMPVIGLGVWRME-----PGEIKELILNAIKIGYRHFDCA---ADYKNEKEVGEALAEafktGLVKREDLFITT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 83 KCsirlagevsgarinhYDTSATHVRSAVETSLRDMGIEQMDLLLLHRP-----------DPLMDADALAAV-------- 143
Cdd:cd19112 76 KL---------------WNSDHGHVIEACKDSLKKLQLDYLDLYLVHFPvatkhtgvgttGSALGEDGVLDIdvtislet 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 144 ----LEQLVAEGKVRQLGVSNY---LPHqtDLLQSRLSQPLVaNQIEVSllqsaPMF--DGQLDYCQQHRVMPMAWSPFA 214
Cdd:cd19112 141 twhaMEKLVSAGLVRSIGISNYdifLTR--DCLAYSKIKPAV-NQIETH-----PYFqrDSLVKFCQKHGISVTAHTPLG 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 215 GGrLFRGDDGDAVRVQQ--ALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19112 213 GA-AANAEWFGSVSPLDdpVLKDLAKKYGKSAA----QIVLRWGIQRNTAVIP--KSSKPERLKENIDVFDFQLSKED 283
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
12-294 |
3.90e-17 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 79.98 E-value: 3.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 12 FSLSRIAFGLWRLTdWSYTPRERLGLFEQM---LDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCSIrl 88
Cdd:cd19077 3 KLVGPIGLGLMGLT-WRPNPTPDEEAFETMkaaLDAGSNLWNGGEFYGP---PDPHANLKLLARFFRKYPEYADKVVL-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 89 agEVSGARINH---YDTSATHVRSAVETSLRDMGI-EQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNyLPH 164
Cdd:cd19077 77 --SVKGGLDPDtlrPDGSPEAVRKSIENILRALGGtKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSE-VSA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 QTdlLQsRLSQ--PLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRL--------------FRGD----DG 224
Cdd:cd19077 154 ET--IR-RAHAvhPIAAVEVEYSLFSREIEENGVLETCAELGIPIIAYSPLGRGLLtgriksladipegdFRRHldrfNG 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2526794215 225 DAVR----VQQALHALCESRGLDPQvgamQLAVAWLLK-HPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19077 231 ENFEknlkLVDALQELAEKKGCTPA----QLALAWILAqSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEI 301
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
15-283 |
1.24e-16 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 77.60 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 15 SRIAFGLWRLTDwSYTPRERLGLFEQM----LDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRLag 90
Cdd:cd19096 1 SVLGFGTMRLPE-SDDDSIDEEKAIEMiryaIDAGINYFDTAYGYGGGKSEEILGEALKEGP--REKFYLATKLPPWS-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 91 evsgarinhyDTSATHVRSAVETSLRDMGIEQMDLLLLH---RPD--PLMDADALAAVLEQLVAEGKVRQLGVSNylpH- 164
Cdd:cd19096 76 ----------VKSAEDFRRILEESLKRLGVDYIDFYLLHglnSPEwlEKARKGGLLEFLEKAKKEGLIRHIGFSF---Hd 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 QTDLLQsrlsQPLVANQIEVSLLQ-------SAPMFDGqLDYCQQHRVMPMAWSPFAGGRLfrgddgdAVRVQQALHALC 237
Cdd:cd19096 143 SPELLK----EILDSYDFDFVQLQynyldqeNQAGRPG-IEYAAKKGMGVIIMEPLKGGGL-------ANNPPEALAILC 210
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2526794215 238 eSRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19096 211 -GAPLSP----AEWALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
8-290 |
5.07e-16 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 76.05 E-value: 5.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 8 LVSDFSLSRIAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKcsir 87
Cdd:cd19134 5 LNDDNTMPVIGLGVGELSD-----DEAERSVSAALEAGYRLIDTAAAYGN---EAAVGRAIAASGIPRGELFVTTK---- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 88 LAGEVSGarinhYDTSathvRSAVETSLRDMGIEQMDLLLLHRPDPLMD--ADALAAVLeQLVAEGKVRQLGVSNYLP-H 164
Cdd:cd19134 73 LATPDQG-----FTAS----QAACRASLERLGLDYVDLYLIHWPAGREGkyVDSWGGLM-KLREEGLARSIGVSNFTAeH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 165 QTDLLQSRLSQPLVaNQIEV-SLLQSAPMFDGQldycQQHRVMPMAWSPFAGGRLFrgdDGDAVRvqqalhALCESRGLD 243
Cdd:cd19134 143 LENLIDLTFFTPAV-NQIELhPLLNQAELRKVN----AQHGIVTQAYSPLGVGRLL---DNPAVT------AIAAAHGRT 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2526794215 244 PQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19134 209 PA----QVLLRWSLQLGNVVIS--RSSNPERIASNLDVFDFELTADH 249
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
44-290 |
3.46e-15 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 74.23 E-value: 3.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 44 LGVTTFDLADIYGDyrcEQAFGEALK----LNPVL-RERMEIVSK--CSirlagevsgarinhyDTSATHVRSAVETSLR 116
Cdd:cd19124 32 VGYRHFDTAAAYGT---EEALGEALAealrLGLVKsRDELFVTSKlwCS---------------DAHPDLVLPALKKSLR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 117 DMGIEQMDLLLLHRP---------------DPL-MDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQPLVAN 180
Cdd:cd19124 94 NLQLEYVDLYLIHWPvslkpgkfsfpieeeDFLpFDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 181 QIEVSllqsaPMFdgQL----DYCQQHRVMPMAWSPFAGGRLFRGDdgDAVRVQQALHALCESRGLDPQvgamQLAVAWL 256
Cdd:cd19124 174 QVEMN-----PAW--QQkklrEFCKANGIHVTAYSPLGAPGTKWGS--NAVMESDVLKEIAAAKGKTVA----QVSLRWV 240
|
250 260 270
....*....|....*....|....*....|....
gi 2526794215 257 LKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19124 241 YEQGVSLVV--KSFNKERMKQNLDIFDWELTEED 272
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
38-289 |
5.53e-15 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 74.14 E-value: 5.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 38 FEQM---LDLGVTTFDLADIY---------GdyRCEQAFGEALKLNPVlRERMEIVSKcsirLAGevSGARINHYDTSAT 105
Cdd:cd19094 21 HEQLdyaFDEGVNFIDTAEMYpvppspetqG--RTEEIIGSWLKKKGN-RDKVVLATK----VAG--PGEGITWPRGGGT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 106 -----HVRSAVETSLRDMGIEQMDLLLLHRPD---PLMD----------------ADALAAvLEQLVAEGKVRQLGVSN- 160
Cdd:cd19094 92 rldreNIREAVEGSLKRLGTDYIDLYQLHWPDrytPLFGggyytepseeedsvsfEEQLEA-LGELVKAGKIRHIGLSNe 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 161 -------YLPHQTDLLQSRLsqplVANQIEVSLLQSApmFDGQL-DYCQQHRVMPMAWSPFAGGRL----FRGDDGD--- 225
Cdd:cd19094 171 tpwgvmkFLELAEQLGLPRI----VSIQNPYSLLNRN--FEEGLaEACHRENVGLLAYSPLAGGVLtgkyLDGAARPegg 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 226 ----------------AVRVQQALHALCESRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDM----E 285
Cdd:cd19094 245 rlnlfpgymaryrspqALEAVAEYVKLARKHGLSP----AQLALAWVRSRPFVTSTIIGATTLEQLKENIDAFDVplsdE 320
|
....
gi 2526794215 286 MERE 289
Cdd:cd19094 321 LLAE 324
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-283 |
5.78e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 73.33 E-value: 5.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 33 ERLGLFEQMLDLGVTTFDLADIYGDyrCEQAFGEALKLNPvlreRMEIVSKCSIRLagevsgariNHYDTSATHVRSAVE 112
Cdd:cd19097 27 EAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRLD----KFKIITKLPPLK---------EDKKEDEAAIEASVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 113 TSLRDMGIEQMDLLLLHRP-DPLMDADALAAVLEQLVAEGKVRQLGVSNYlpHQTDLLQSRLSQPLVANQIEVSLLQSAP 191
Cdd:cd19097 92 ASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSVY--SPEELEKALESFKIDIIQLPFNILDQRF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 192 MFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDDG------DAVRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVP 265
Cdd:cd19097 170 LKSGLLAKLKKKGIEIHARSVFLQGLLLMEPDKlpakfaPAKPLLKKLHELAKKLGLSPL----ELALGFVLSLPEIDKI 245
|
250
....*....|....*...
gi 2526794215 266 VLGSGNPERLVAALAALD 283
Cdd:cd19097 246 VVGVDSLEQLKEIIAAFK 263
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
42-301 |
5.95e-15 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 73.18 E-value: 5.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCsirlagevsgarinhYDTSATHVRSAVETSLRDMGIE 121
Cdd:PRK11565 38 LEVGYRSIDTAAIYKN---EEGVGKALKEASVAREELFITTKL---------------WNDDHKRPREALEESLKKLQLD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 122 QMDLLLLHRPDPLMD--ADALAAVLEqLVAEGKVRQLGVSNYLPHQtdlLQSRLSQPLVA---NQIEV-SLLQSApmfdg 195
Cdd:PRK11565 100 YVDLYLMHWPVPAIDhyVEAWKGMIE-LQKEGLIKSIGVCNFQIHH---LQRLIDETGVTpviNQIELhPLMQQR----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 196 QLD-YCQQHRVMPMAWSPFAGGrlfrgddGDAVRVQQALHALCESRGLDPQvgamQLAVAWLLKhpAKMVPVLGSGNPER 274
Cdd:PRK11565 171 QLHaWNATHKIQTESWSPLAQG-------GKGVFDQKVIRDLADKYGKTPA----QIVIRWHLD--SGLVVIPKSVTPSR 237
|
250 260
....*....|....*....|....*..
gi 2526794215 275 LVAALAALDMEMEREDWYELLRAGRGR 301
Cdd:PRK11565 238 IAENFDVFDFRLDKDELGEIAKLDQGK 264
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
39-166 |
1.46e-14 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 72.59 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 39 EQMLDL----GVTTFDLADIYGDYRCEQAFGEALklnpvlrermeiVSKCSIRLAGEVSGARINHYdtSATHVRSAVETS 114
Cdd:cd19075 23 AELLDAflerGHTEIDTARVYPDGTSEELLGELG------------LGERGFKIDTKANPGVGGGL--SPENVRKQLETS 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2526794215 115 LRDMGIEQMDLLLLHRPD---PLmdADALAAVlEQLVAEGKVRQLGVSNYLPHQT 166
Cdd:cd19075 89 LKRLKVDKVDVFYLHAPDrstPL--EETLAAI-DELYKEGKFKEFGLSNYSAWEV 140
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
24-277 |
1.91e-14 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 72.15 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 24 LTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCsirlagevsgarinhYDTS 103
Cdd:cd19117 19 LGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGN---EEEVGQGIKDSGVPREEIFITTKL---------------WCTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 104 ATHVRSAVETSLRDMGIEQMDLLLLHRPDPL---------MDADALAAV------------LEQLVAEGKVRQLGVSNY- 161
Cdd:cd19117 81 HRRVEEALDQSLKKLGLDYVDLYLMHWPVPLdpdgndflfKKDDGTKDHepdwdfiktwelMQKLPATGKVKAIGVSNFs 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 162 LPHQTDLLQSRLSQPLVA-NQIEVSLLQSAPMFdgqLDYCQQHRVMPMAWSPFaggrlfrGDDGDAVRVQQALHALCESR 240
Cdd:cd19117 161 IKNLEKLLASPSAKIVPAvNQIELHPLLPQPKL---VDFCKSKGIHATAYSPL-------GSTNAPLLKEPVIIKIAKKH 230
|
250 260 270
....*....|....*....|....*....|....*..
gi 2526794215 241 GLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVA 277
Cdd:cd19117 231 GKTPA----QVIISWGLQRGYSVLP--KSVTPSRIES 261
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
18-287 |
3.19e-14 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 71.41 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 18 AFGLwrlTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALK---LNPVLRERMEIVSKCsirlagevsg 94
Cdd:cd19121 14 AVGL---GTWQAKAGEVKAAVAHALKIGYRHIDGALCYQN---EDEVGEGIKeaiAGGVKREDLFVTTKL---------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 95 arinhYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMD----------ADALAAV------------LEQLVAEGK 152
Cdd:cd19121 78 -----WSTYHRRVELCLDRSLKSLGLDYVDLYLVHWPVLLNPngnhdlfptlPDGSRDLdwdwnhvdtwkqMEKVLKTGK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 153 VRQLGVSNY-LPHQTDLLQSRLSQPlVANQIEV--SLLQSApmfdgQLDYCQQHRVMPMAWSPF--AGGRLFRGDDgdav 227
Cdd:cd19121 153 TKAIGVSNYsIPYLEELLKHATVVP-AVNQVENhpYLPQQE-----LVDFCKEKGILIEAYSPLgsTGSPLISDEP---- 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 228 rvqqaLHALCESRGLDPqvgamqlAVAWLLKHPAKMVPVL-GSGNPERLVAALAALDMEME 287
Cdd:cd19121 223 -----VVEIAKKHNVGP-------GTVLISYQVARGAVVLpKSVTPDRIKSNLEIIDLDDE 271
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
50-294 |
5.47e-14 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 70.84 E-value: 5.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 50 DLADIYGDyrcEQAFGEALK--LNP--VLRERMEIVSK--CSirlagevsgarinhyDTSATHVRSAVETSLRDMGIEQM 123
Cdd:cd19125 42 DCAAIYGN---EKEIGKALKklFEDgvVKREDLFITSKlwCT---------------DHAPEDVPPALEKTLKDLQLDYL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 124 DLLLLHRP----------DPLM----DADALAAVLEQLVAEGKVRQLGVSNY-LPHQTDLLQSRLSQPLVaNQIEV-SLL 187
Cdd:cd19125 104 DLYLIHWPvrlkkgahmpEPEEvlppDIPSTWKAMEKLVDSGKVRAIGVSNFsVKKLEDLLAVARVPPAV-NQVEChPGW 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 188 QSAPMFdgqlDYCQQHRVMPMAWSPFagGRLFRGDDGDAVRVQQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvl 267
Cdd:cd19125 183 QQDKLH----EFCKSKGIHLSAYSPL--GSPGTTWVKKNVLKDPIVTKVAEKLGKTPA----QVALRWGLQRGTSVLP-- 250
|
250 260
....*....|....*....|....*..
gi 2526794215 268 GSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19125 251 KSTNEERIKENIDVFDWSIPEEDFAKF 277
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
18-304 |
1.99e-13 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 68.90 E-value: 1.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 18 AFGL--WRLTDWSYTPRERLGLfeqmlDLGVTTFDLADIYGDyrcEQAFGEALKLNPVLRERMEIVSKCsirlagevsga 95
Cdd:PRK11172 5 AFGLgtFRLKDQVVIDSVKTAL-----ELGYRAIDTAQIYDN---EAAVGQAIAESGVPRDELFITTKI----------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 96 RINHYdtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPlMDADALAAVLEQLV---AEGKVRQLGVSNYlphQTDLLQSR 172
Cdd:PRK11172 66 WIDNL--AKDKLIPSLKESLQKLRTDYVDLTLIHWPSP-NDEVSVEEFMQALLeakKQGLTREIGISNF---TIALMKQA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 173 L----SQPLVANQIEVS-LLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFrgddGDAVrvqqaLHALCESRGLDPQvg 247
Cdd:PRK11172 140 IaavgAENIATNQIELSpYLQNRKV----VAFAKEHGIHVTSYMTLAYGKVL----KDPV-----IARIAAKHNATPA-- 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2526794215 248 amQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMEREDWYELLRAGR-GREVD 304
Cdd:PRK11172 205 --QVILAWAMQLGYSVIP--SSTKRENLASNLLAQDLQLDAEDMAAIAALDRnGRLVS 258
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
49-275 |
4.93e-13 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 67.82 E-value: 4.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 49 FDLADIYGD-YRCEQAFGEALKLNPVL-RERMEIVSK---CSIRLAgevsgarinhydtsatHVRSAVETSLRDMGIEQM 123
Cdd:cd19118 37 LDLAKVYQNqHEVGQALKELLKEEPGVkREDLFITSKlwnNSHRPE----------------YVEPALDDTLKELGLDYL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 124 DLLLLHRP------------------DPLMDAD---ALAAVLEQLVA---EGKVRQLGVSNYLP-HQTDLLQSRLSQPLV 178
Cdd:cd19118 101 DLYLIHWPvafkptgdlnpltavptnGGEVDLDlsvSLVDTWKAMVElkkTGKVKSIGVSNFSIdHLQAIIEETGVVPAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 179 aNQIEV-SLLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLfrgddGDAVRVQQ-ALHALCESRGLDPQvgamQLAVAWL 256
Cdd:cd19118 181 -NQIEAhPLLLQDEL----VDYCKSKNIHITAYSPLGNNLA-----GLPLLVQHpEVKAIAAKLGKTPA----QVLIAWG 246
|
250
....*....|....*....
gi 2526794215 257 LKHPAKMVPvlGSGNPERL 275
Cdd:cd19118 247 IQRGHSVIP--KSVTPSRI 263
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
42-281 |
6.94e-13 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 67.69 E-value: 6.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrCEQAFGEALK--LNPVLRERMEIVSKCsirlaGEVSGariNHYDTSATHVRSAVETSLRDMG 119
Cdd:cd19164 44 LELGIRAFDTSPYYGP--SEIILGRALKalRDEFPRDTYFIITKV-----GRYGP---DDFDYSPEWIRASVERSLRRLH 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 120 IEQMDLLLLHRPDPLMDADALAAV--LEQLVAEGKVRQLGVSNY----LPHQTDLLQSRLSQPLVA-------NQIEVSL 186
Cdd:cd19164 114 TDYLDLVYLHDVEFVADEEVLEALkeLFKLKDEGKIRNVGISGYplpvLLRLAELARTTAGRPLDAvlsychyTLQNTTL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 187 LQSAPMFDGqldyCQQHRVMPMAwSPFAGGRLFRGDDGD--------AVRVQQALhALCESRGLDpqvgAMQLAVAWLLK 258
Cdd:cd19164 194 LAYIPKFLA----AAGVKVVLNA-SPLSMGLLRSQGPPEwhpaspelRAAAAKAA-EYCQAKGTD----LADVALRYALR 263
|
250 260
....*....|....*....|....
gi 2526794215 259 HPAKMVP-VLGSGNPERLVAALAA 281
Cdd:cd19164 264 EWGGEGPtVVGCSNVDELEEAVEA 287
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
8-294 |
1.43e-12 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 66.67 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 8 LVSDFSLSRIAFGLWRLTdwsytPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALK--LNP--VLRERMEIVSK 83
Cdd:cd19154 6 LSNGVKMPLIGLGTWQSK-----GAEGITAVRTALKAGYRLIDTAFLYQN---EEAIGEALAelLEEgvVKREDLFITTK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 84 CSirlagevsgariNHYDTSAThVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAV-------------------L 144
Cdd:cd19154 78 LW------------THEHAPED-VEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTmengmsihdavdvedvwrgM 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 145 EQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQPLVANQIEVSLLQsaPMFDGQlDYCQQHRVMPMAWSPFA--GGRLFRGD 222
Cdd:cd19154 145 EKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYF--PQKELV-EFCKKHNISVTSYATLGspGRANFTKS 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 223 DGDAVRVQQALHALCESRGLDPQVGAMQLAVAWLLKHPAKMVPVlgSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19154 222 TGVSPAPNLLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPK--SATPSRIKENFNIFDFSLSEEDMATL 291
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
42-294 |
1.04e-11 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 64.17 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKC-------SIRLAGEVSGARINH-----YDTSATHVRS 109
Cdd:cd19152 30 WDLGIRYFDTAPWYGAGLSEERLGAALRELG--REDYVISTKVgrllvplQEVEPTFEPGFWNPLpfdavFDYSYDGILR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 110 AVETSLRDMGIEQMDLLLLHRPDPLMDADALAAV-----------LEQLVAEGKVRQLGV-SNYLPHQTDLLQ-SRLSQP 176
Cdd:cd19152 108 SIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEHfaqaikgafraLEELREEGVIKAIGLgVNDWEVILRILEeADLDWV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 177 LVANQieVSLLQSAPMFDgQLDYCQQHRVMPMAWSPF-----AGGRLFRGDDG-----DAVRVQQALHALCESRGLDPQV 246
Cdd:cd19152 188 MLAGR--YTLLDHSAARE-LLPECEKRGVKVVNAGPFnsgflAGGDNFDYYEYgpappELIARRDRIEALCEQHGVSLAA 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2526794215 247 GAMQLAVAwllkHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19152 265 AALQFALA----PPAVASVAPGASSPERVEENVALLATEIPAAFWEEL 308
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
37-283 |
2.39e-11 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 63.38 E-value: 2.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 37 LFEQMLDLGVTTFDLADIYGDYRCEQAFGEALK-LNpvlRERMEIVskCSIRLAGEVSGARINHYDTSATHVRSAVETSL 115
Cdd:cd19143 36 CMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKeLG---WPRSDYV--VSTKIFWGGGGPPPNDRGLSRKHIVEGTKASL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 116 RDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNY----------LPHQTDLLQSRLSQP----LVANQ 181
Cdd:cd19143 111 KRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWsaqqieeaheIADRLGLIPPVMEQPqynlFHRER 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 182 IEVsllQSAPMFdgqldycQQHRVMPMAWSPFAGGRLF-----------RGDDGDAVRVQQALHALCES-----RGLDP- 244
Cdd:cd19143 191 VEV---EYAPLY-------EKYGLGTTTWSPLASGLLTgkynngipegsRLALPGYEWLKDRKEELGQEkiekvRKLKPi 260
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2526794215 245 --QVGAM--QLAVAWLLKHPAKMVPVLGSGNPERLVAALAALD 283
Cdd:cd19143 261 aeELGCSlaQLAIAWCLKNPNVSTVITGATKVEQLEENLKALE 303
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
24-299 |
6.90e-11 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 61.90 E-value: 6.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 24 LTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRcEQAFG--EALKLNPVLRERMEIVSK--CSIRlagevsgarinh 99
Cdd:cd19110 9 LGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNES-EVGAGirEKIKEGVVRREDLFIVSKlwCTCH------------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 100 ydtSATHVRSAVETSLRDMGIEQMDLLLLHRP--------DPLMDADALA-----------AVLEQLVAEGKVRQLGVSN 160
Cdd:cd19110 76 ---KKSLVKTACTRSLKALKLNYLDLYLIHWPmgfkpgepDLPLDRSGMVipsdtdfldtwEAMEDLVIEGLVKNIGVSN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 161 YLPHQtdlLQSRLSQP-----LVANQIEVSllqsaPMFDGQ--LDYCQQHRVMPMAWSPFAGgrlfrGDDGDAVRVQQAL 233
Cdd:cd19110 153 FNHEQ---LERLLNKPglrvkPVTNQIECH-----PYLTQKklISFCQSRNVSVTAYRPLGG-----SCEGVDLIDDPVI 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2526794215 234 HALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMEREDWYELLRAGR 299
Cdd:cd19110 220 QRIAKKHGKSPA----QILIRFQIQRNVIVIP--KSVTPSRIKENIQVFDFELTEHDMDNLLSLDR 279
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
39-284 |
1.10e-10 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 61.60 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 39 EQMLDL----GVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKcsIRLAGEVSGARinhyDTSATHVRSAVETS 114
Cdd:cd19159 34 ERLMTIayesGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTK--LYWGGKAETER----GLSRKHIIEGLKGS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 115 LRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQ----PLVANQIEVSLLQSA 190
Cdd:cd19159 108 LQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQfnmiPPVCEQAEYHLFQRE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 191 PMfDGQL-DYCQQHRVMPMAWSPFAGGrLFRGDDGDAV-----------------------RVQQAlhALCESRGLDPQV 246
Cdd:cd19159 188 KV-EVQLpELYHKIGVGAMTWSPLACG-IISGKYGNGVpessraslkcyqwlkerivseegRKQQN--KLKDLSPIAERL 263
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2526794215 247 GAM--QLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDM 284
Cdd:cd19159 264 GCTlpQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQV 303
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
42-284 |
2.14e-10 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 60.33 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrcEQAFGEA----LKLNP-VLRERMEIVSKCsirlagevsgarINHYDtSATHVRSAVETSLR 116
Cdd:cd19122 34 LDVGYRHLDCAWFYLN---EDEVGDAvrdfLKENPsVKREDLFICTKV------------WNHLH-EPEDVKWSIDNSLK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 117 DMGIEQMDLLLLHRP---------DPLMDADALAAVL--------------EQLVAEGKVRQLGVSNY-LPHQTDLLQSR 172
Cdd:cd19122 98 NLKLDYIDLFLVHWPiaaekndqrSPKLGPDGKYVILkdltenpeptwramEEIYESGKAKAIGVSNWtIPGLKKLLSFA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 173 LSQPLVaNQIEVSllqsaPMFDGQ--LDYCQQHRVMPMAWSPFaGGRLFRGDDGDAVRVQQALHALCESRGLDpqvgAMQ 250
Cdd:cd19122 178 KVKPHV-NQIEIH-----PFLPNEelVDYCFSNDILPEAYSPL-GSQNQVPSTGERVSENPTLNEVAEKGGYS----LAQ 246
|
250 260 270
....*....|....*....|....*....|....
gi 2526794215 251 LAVAWLLKHPAKMVPvlGSGNPERLVAALAALDM 284
Cdd:cd19122 247 VLIAWGLRRGYVVLP--KSSTPSRIESNFKSIEL 278
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
42-290 |
4.23e-10 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 59.71 E-value: 4.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrcEQAFGEALK-----LNPVLRERMEIVSKCsirlagevsgarinhYDTS--ATHVRSAVETS 114
Cdd:cd19106 30 LDAGYRHIDCAAVYGN---EQEVGEALKekvgpGKAVPREDLFVTSKL---------------WNTKhhPEDVEPALRKT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 115 LRDMGIEQMDLLLLHRP--------------DPLMDADALA-----AVLEQLVAEGKVRQLGVSNYLPHQ-TDLLQSRLS 174
Cdd:cd19106 92 LKDLQLDYLDLYLIHWPyafergdnpfpknpDGTIRYDSTHyketwKAMEKLVDKGLVKAIGLSNFNSRQiDDILSVARI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 175 QPLVaNQIEvsllqSAPMFDGQ--LDYCQQHRVMPMAWSPFAG-GRLFRgDDGDAVRVQQ-ALHALCESRGLDPQvgamQ 250
Cdd:cd19106 172 KPAV-LQVE-----CHPYLAQNelIAHCKARGLVVTAYSPLGSpDRPWA-KPDEPVLLEEpKVKALAKKYNKSPA----Q 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2526794215 251 LAVAWLLKHpaKMVPVLGSGNPERLVAALAALDMEMERED 290
Cdd:cd19106 241 ILLRWQVQR--GVVVIPKSVTPSRIKQNIQVFDFTLSPEE 278
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
50-217 |
8.00e-10 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 58.66 E-value: 8.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 50 DLADIYGdyrCEQAFGEALK----LNPVLRERMEIVSKCsirlagevsgarinhYDTSATHVRSAVETSLRDMGIEQMDL 125
Cdd:cd19119 45 DTAYAYE---TEDFVGEAIKraidDGSIKREELFITTKV---------------WPTFYDEVERSLDESLKALGLDYVDL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 126 LLLHRPDPL-----------------------MDADALAAV--LEQLVAEGKVRQLGVSNY-LPHQTDLLQSRLSQPLVa 179
Cdd:cd19119 107 LLVHWPVCFekdsddsgkpftpvnddgktryaASGDHITTYkqLEKIYLDGRAKAIGVSNYsIVYLERLIKECKVVPAV- 185
|
170 180 190
....*....|....*....|....*....|....*...
gi 2526794215 180 NQIEVSLLqsAPMFDgQLDYCQQHRVMPMAWSPFAGGR 217
Cdd:cd19119 186 NQVELHPH--LPQMD-LRDFCFKHGILVTAYSPLGSHG 220
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
38-161 |
1.02e-09 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 58.32 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 38 FEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKCSIRLAGEvsgarinhYDTSATHVRSAVETSLRD 117
Cdd:cd19153 39 VAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATKVGRYRDSE--------FDYSAERVRASVATSLER 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2526794215 118 MGIEQMDLLLLH-----RPDPLMDaDALAAvLEQLVAEGKVRQLGVSNY 161
Cdd:cd19153 111 LHTTYLDVVYLHdiefvDYDTLVD-EALPA-LRTLKDEGVIKRIGIAGY 157
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
24-294 |
1.61e-09 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 57.51 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 24 LTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALKL----NPVLRERMEIVSKCSIrlagevsgarinh 99
Cdd:cd19111 9 LGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWwlknGKLKREEVFITTKLPP------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 100 YDTSATHVRSAVETSLRDMGIEQMDLLLLHRP-------DPLMDADALAAV------LEQLVAEGKVRQLGVSNYLPHQT 166
Cdd:cd19111 73 VYLEFKDTEKSLEKSLENLKLPYVDLYLIHHPcgfvnkkDKGERELASSDVtsvwraMEALVSEGKVKSIGLSNFNPRQI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 167 D-LLQSRLSQPlvAN-QIEVSL-LQSAPMfdgqLDYCQQHRVMPMAWSPFaggrlfrgddGDAVRVQQALHALCESRGLD 243
Cdd:cd19111 153 NkILAYAKVKP--SNlQLECHAyLQQREL----RKFCNKKNIVVTAYAPL----------GSPGRANQSLWPDQPDLLED 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 244 PQVgamqLAVAWLL-KHPAKM----------VPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19111 217 PTV----LAIAKELdKTPAQVllrfvlqrgtGVLPKSTNKERIEENFEVFDFELTEEHFKKL 274
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
8-294 |
3.13e-09 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 57.07 E-value: 3.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 8 LVSDFSLSRIAFGLWRLT-----DWSYtprerlglfeQMLDLGVTTFDLADIYGDyrcEQAFGE----ALKLNPVLRERM 78
Cdd:cd19113 5 LNSGYKMPSVGFGCWKLDnataaDQIY----------QAIKAGYRLFDGAEDYGN---EKEVGEgvnrAIDEGLVKREEL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 79 EIVSKCsirlagevsgarINHYDtSATHVRSAVETSLRDMGIEQMDLLLLHRP---------------------D----- 132
Cdd:cd19113 72 FLTSKL------------WNNFH-DPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycgdgDnfvye 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 133 --PLMDAdalAAVLEQLVAEGKVRQLGVSNYlPHQ--TDLLQSRLSQPlVANQIEVSLLQSAPMFdgqLDYCQQHRVMPM 208
Cdd:cd19113 139 dvPILDT---WKALEKLVDAGKIKSIGVSNF-PGAliLDLLRGATIKP-AVLQIEHHPYLQQPKL---IEYAQKAGITIT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 209 AWSPFAGGRLFRGDDGDAVRVQ-----QALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALD 283
Cdd:cd19113 211 AYSSFGPQSFVELNQGRALNTPtlfehDTIKSIAAKHNKTPA----QVLLRWATQRGIAVIP--KSNLPERLLQNLSVND 284
|
330
....*....|.
gi 2526794215 284 MEMEREDWYEL 294
Cdd:cd19113 285 FDLTKEDFEEI 295
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
30-294 |
4.78e-09 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 56.57 E-value: 4.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 30 TPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvlRERMEIVSKCSIRLAGEVSGARIN----------- 98
Cdd:cd19161 18 SNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKP--RDEFVLSTKVGRLLKPAREGSVPDpngfvdplpfe 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 99 -HYDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAV------------LEQLVAEGKVRQ--LGVSNYLP 163
Cdd:cd19161 96 iVYDYSYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRKERHhfaqlmsggfkaLEELKKAGVIKAfgLGVNEVQI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 164 HQTDLLQSRLSQPLVANqiEVSLLQSAPMfDGQLDYCQQHRVMPMAWSPFAGGRLFRG-------DDGDAV-----RVqQ 231
Cdd:cd19161 176 CLEALDEADLDCFLLAG--RYSLLDQSAE-EEFLPRCEQRGTSLVIGGVFNSGILATGtksgakfNYGDAPaeiisRV-M 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2526794215 232 ALHALCESRGLDPQVGAMQLAvawlLKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19161 252 EIEKICDAYNVPLAAAALQFP----LRHPAVASVLTGARNPAQLRQNVEAFQTDIPEELWQAL 310
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
42-159 |
5.54e-09 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 56.32 E-value: 5.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKCsirlagevsGARINHYDTSATHVRSAVETSLRDMGIE 121
Cdd:PLN02587 41 FRLGINFFDTSPYYGGTLSEKVLGKALKALGIPREKYVVSTKC---------GRYGEGFDFSAERVTKSVDESLARLQLD 111
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2526794215 122 QMDLLLLHrpdplmdaDALAAVLEQLVAE-----------GKVRQLGVS 159
Cdd:PLN02587 112 YVDILHCH--------DIEFGSLDQIVNEtipalqklkesGKVRFIGIT 152
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
5-290 |
1.49e-08 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 55.12 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 5 QSSLVSDFSLSRIAFGLWRLT-----DWSYtprerlglfeQMLDLGVTTFDLADIYG-DYRCEQAFGEALKLNPVLRERM 78
Cdd:cd19115 4 TVKLNSGYDMPLVGFGLWKVNndtcaDQVY----------NAIKAGYRLFDGACDYGnEVEAGQGVARAIKEGIVKREDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 79 EIVSKC-SIRLAGEvsgarinhydtsatHVRSAVETSLRDMGIEQMDLLLLHRP------DP--------LMDADALA-- 141
Cdd:cd19115 74 FIVSKLwNTFHDGE--------------RVEPICRKQLADWGIDYFDLFLIHFPialkyvDPavryppgwFYDGKKVEfs 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 142 --------AVLEQLVAEGKVRQLGVSNYLPHQT-DLLQSRLSQPLVAnQIEVS--LLQSApmfdgQLDYCQQHRVMPMAW 210
Cdd:cd19115 140 napiqetwTAMEKLVDKGLARSIGVSNFSAQLLmDLLRYARIRPATL-QIEHHpyLTQPR-----LVKYAQKEGIAVTAY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 211 SPFAGGRLFRGDDGDAVRV-----QQALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDME 285
Cdd:cd19115 214 SSFGPQSFLELDLPGAKDTpplfeHDVIKSIAEKHGKTPA----QVLLRWATQRGIAVIP--KSNNPKRLAQNLDVTGFD 287
|
....*
gi 2526794215 286 MERED 290
Cdd:cd19115 288 LEAEE 292
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
10-288 |
1.95e-08 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 54.78 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRltdwSYTPRERLGLFEQMLDL----GVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKcs 85
Cdd:cd19142 9 SGLRVSNVGLGTWS----TFSTAISEEQAEEIVTLayenGINYFDTSDAFTSGQAETELGRILKKKGWKRSSYIVSTK-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 86 IRLAGEVSGARInhydtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQ 165
Cdd:cd19142 83 IYWSYGSEERGL-----SRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 166 --------------TDLLQSRLSQPLVANQIEVSLLQsapMFdgqldycqqHR--VMPMAWSPFAGG-----------RL 218
Cdd:cd19142 158 imeafsiarqfncpTPICEQSEYHMFCREKMELYMPE---LY---------NKvgVGLITWSPLSLGldpgiseetrrLV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 219 FR--------------GDDGDAVRVQQA----LHALCESRGLDPqvgaMQLAVAWLLKHPAKMVPVLGSGNPERLVAALA 280
Cdd:cd19142 226 TKlsfksskykvgsdgNGIHEETRRASHklreLSLIAERLGCDL----TQLLIAWSLKNENVQCVLIGASSLEQLYSQLN 301
|
330
....*....|....*...
gi 2526794215 281 ALDM----------EMER 288
Cdd:cd19142 302 SLQLlpklnsavmeELER 319
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
45-282 |
3.26e-08 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 53.99 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 45 GVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKcsIRLAGEVSGARinhyDTSATHVRSAVETSLRDMGIEQMD 124
Cdd:cd19141 43 GINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTK--IFWGGKAETER----GLSRKHIIEGLKASLERLQLEYVD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 125 LLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQ----PLVANQIEVSLLQSAPMfDGQLDYC 200
Cdd:cd19141 117 IVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEAYSVARQfnliPPIVEQAEYHLFQREKV-EMQLPEL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 201 qQHR--VMPMAWSPFAGGrLFRGDDGDAV-----------------------RVQQALhaLCESRGLDPQVGAM--QLAV 253
Cdd:cd19141 196 -FHKigVGAMTWSPLACG-ILSGKYDDGVpeysraslkgyqwlkekilseegRRQQAK--LKELQIIADRLGCTlpQLAI 271
|
250 260
....*....|....*....|....*....
gi 2526794215 254 AWLLKHPAKMVPVLGSGNPERLVAALAAL 282
Cdd:cd19141 272 AWCLKNEGVSSVLLGASSTEQLYENLQAI 300
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
10-284 |
4.48e-08 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 53.55 E-value: 4.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 10 SDFSLSRIAFGLWRLTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKcsIRLA 89
Cdd:cd19158 9 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTK--IFWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 90 GEVSGARinhyDTSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLL 169
Cdd:cd19158 87 GKAETER----GLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 170 QSRLSQ----PLVANQIEVSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGrLFRGDDGDAV------------------ 227
Cdd:cd19158 163 YSVARQfnliPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACG-IVSGKYDSGIppysraslkgyqwlkdki 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2526794215 228 -----RVQQAlhALCESRGLDPQVGAM--QLAVAWLLKHPAKMVPVLGSGNPERLVAALAALDM 284
Cdd:cd19158 242 lseegRRQQA--KLKELQAIAERLGCTlpQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQV 303
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
42-213 |
4.52e-08 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 53.58 E-value: 4.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADIYGDyrcEQAFGEA----LKLNPVLRERMEIVSK--CSIrlagevsgarinhYDTSAthVRSAVETSL 115
Cdd:cd19107 27 IDAGYRHIDCAYVYQN---ENEVGEAiqekIKEQVVKREDLFIVSKlwCTF-------------HEKGL--VKGACQKTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 116 RDMGIEQMDLLLLHRP------DPLMDADALAAVL-------------EQLVAEGKVRQLGVSNYLPHQTDLLQSR--LS 174
Cdd:cd19107 89 SDLKLDYLDLYLIHWPtgfkpgKELFPLDESGNVIpsdttfldtweamEELVDEGLVKAIGVSNFNHLQIERILNKpgLK 168
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2526794215 175 QPLVANQIEVS--LLQsapmfDGQLDYCQQHRVMPMAWSPF 213
Cdd:cd19107 169 YKPAVNQIECHpyLTQ-----EKLIQYCQSKGIVVTAYSPL 204
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
17-290 |
7.62e-08 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 52.56 E-value: 7.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 17 IAFGLWRLTDwsytpRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFG----EALKLNPVLRERMEIVSKCsirlagev 92
Cdd:cd19114 7 VGFGTAKIKA-----NETEEVIYNAIKVGYRLIDGALLYGN---EAEVGrgirKAIQEGLVKREDLFIVTKL-------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 93 sgarINHYDtSATHVRSAVETSLRDMGIEQMDLLLLHRPDPLM-------------DADALAAVLEQ------------L 147
Cdd:cd19114 71 ----WNNFH-GKDHVREAFDRQLKDYGLDYIDLYLIHFPIPAAyvdpaenypflwkDKELKKFPLEQspmqecwremekL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 148 VAEGKVRQLGVSNYLPHQT-DLLQSRLSQPLVAnQIEV-SLLQSAPMfdgqLDYCQQHRVMPMAWSPFAGGRLFRGDDGD 225
Cdd:cd19114 146 VDAGLVRNIGIANFNVQLIlDLLTYAKIKPAVL-QIEHhPYLQQKRL----IDWAKKQGIQITAYSSFGNAVYTKVTKHL 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2526794215 226 AVRVQQALHALCESRGLDPQVGAMQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19114 221 KHFTNLLEHPVVKKLADKHKRDTGQVLLRWAVQRNITVIP--KSVNVERMKTNLDITSYKLDEED 283
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
45-282 |
1.33e-07 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 52.29 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 45 GVTTFDLADIYGDYRCEQAFGEALKLNPVLRERMEIVSKcsIRLAGEVSGARinhyDTSATHVRSAVETSLRDMGIEQMD 124
Cdd:cd19160 46 GVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVTTK--IYWGGQAETER----GLSRKHIIEGLRGSLDRLQLEYVD 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 125 LLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSNYLPHQTDLLQSRLSQ----PLVANQIEVSLLQSAPMfDGQL-DY 199
Cdd:cd19160 120 IVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVARQfnliPPVCEQAEYHLFQREKV-EMQLpEL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 200 CQQHRVMPMAWSPFAGGRLFRGDDG---DAVRV-------------------QQA----LHALCESRGLDpqvgAMQLAV 253
Cdd:cd19160 199 YHKIGVGSVTWSPLACGLITGKYDGrvpDTCRAavkgyqwlkekvqseegkkQQAkvkeLHPIADRLGCT----VAQLAI 274
|
250 260
....*....|....*....|....*....
gi 2526794215 254 AWLLKHPAKMVPVLGSGNPERLVAALAAL 282
Cdd:cd19160 275 AWCLRSEGVSSVLLGVSSAEQLIENLGSI 303
|
|
| PRK14863 |
PRK14863 |
bifunctional regulator KidO; Provisional |
107-294 |
6.09e-07 |
|
bifunctional regulator KidO; Provisional
Pssm-ID: 184865 [Multi-domain] Cd Length: 292 Bit Score: 49.92 E-value: 6.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 107 VRSAVETSLRDMGIEQMDLLLLHRPDPLMDADAlAAVLEQLVA---EGKVRQLGVSNYLPHQTDLLQSRLSQPLVanQIE 183
Cdd:PRK14863 88 VEAEARASLRRMGVERADAILVHSPTELFGPHG-AALWERLQAlkdQGLFAKIGVSAHASDDPVGVARRFKPDIL--QAP 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 184 VSLLQSAPMFDGQLDYCQQHRVMPMAWSPFAGGRLFRGDD-------GDAVRVQQALHALCESRgLDPqvgaMQLAVAWL 256
Cdd:PRK14863 165 ASLLDQRLLADGSLQRIAGMGVEVHLRSIFLNGLLFLPPDrvpaqlkGASGRLSRVRRMIAEGR-SDP----LQAALGFA 239
|
170 180 190
....*....|....*....|....*....|....*...
gi 2526794215 257 LKHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:PRK14863 240 LSRPEGSAVLVGVNSAAELSAVVAAASSPPPDLDWDDM 277
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
107-290 |
1.46e-06 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 49.03 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 107 VRSAVETSLRDMGIEQMDLLLLHRPDPLMDADA----------------LAAVLEQLVA---EGKVRQLGVSNYLPHQTD 167
Cdd:cd19109 84 VRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEiyprdengkwlyhktnLCATWEALEAckdAGLVKSIGVSNFNRRQLE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 168 LLQSR--LSQPLVANQIEVSllqsaPMFDGQ--LDYCQQHRVMPMAWSPFaggrlfrGDDGDAVRVQQALHALCE----- 238
Cdd:cd19109 164 LILNKpgLKHKPVSNQVECH-----PYFTQPklLEFCQQHDIVIVAYSPL-------GTCRDPIWVNVSSPPLLEdplln 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2526794215 239 SRGLDPQVGAMQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMERED 290
Cdd:cd19109 232 SIGKKYNKTAAQVVLRFNIQRGVVVIP--KSFNPERIKENFQIFDFSLTEEE 281
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
50-294 |
1.67e-06 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 48.96 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 50 DLADIYGDYRCEQAFGE--ALKLNpvlRERMEIVSKCSI--RLAGEVSgARINHYDTSATHVRSAVETSLRDMGIEQMDL 125
Cdd:cd19146 53 DTANNYQGEESERWVGEwmASRGN---RDEMVLATKYTTgyRRGGPIK-IKSNYQGNHAKSLRLSVEASLKKLQTSYIDI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 126 LLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSN----YLPHQTDLLQSRLSQPLVANQIEvsllQSAPMFDGQLDYCQ 201
Cdd:cd19146 129 LYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDtpawVVSKANAYARAHGLTQFVVYQGH----WSAAFRDFERDILP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 202 QHRVMPMAWSPF------------------AGGRLFRGDDGDAVRVQQALHALCESRGldpqVGAMQLAVAWLLKHPAKM 263
Cdd:cd19146 205 MCEAEGMALAPWgvlgqgqfrteeefkrrgRSGRKGGPQTEKERKVSEKLEKVAEEKG----TAITSVALAYVMHKAPYV 280
|
250 260 270
....*....|....*....|....*....|.
gi 2526794215 264 VPVLGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19146 281 FPIVGGRKVEHLKGNIEALGISLSDEEIQEI 311
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
31-299 |
5.30e-06 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 46.89 E-value: 5.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 31 PRER---LGLFEQMLDLGVTTFDLADIYGDYRCEQAFGEALklNPvLRERMEIVSKCSIRLAGEVS--GARinhydtSAT 105
Cdd:PRK10376 36 PKDRdaaIAVLREAVALGVNHIDTSDFYGPHVTNQLIREAL--HP-YPDDLTIVTKVGARRGEDGSwlPAF------SPA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 106 HVRSAVETSLRDMGIEQMDLLLL------HRPDPLMDADALAAVLEqLVAEGKVRQLGVSNYLPHQtdLLQSRLSQPLVA 179
Cdd:PRK10376 107 ELRRAVHDNLRNLGLDVLDVVNLrlmgdgHGPAEGSIEEPLTVLAE-LQRQGLVRHIGLSNVTPTQ--VAEARKIAEIVC 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 180 NQIEVSLLQSAPmfDGQLDYCQQHRVmpmAWSPF--AGGrlFRGDDGDavrvqqALHALCESRGLDPqvgaMQLAVAWLL 257
Cdd:PRK10376 184 VQNHYNLAHRAD--DALIDALARDGI---AYVPFfpLGG--FTPLQSS------TLSDVAASLGATP----MQVALAWLL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2526794215 258 KHPAKMVPVLGSGNPERLVAALAALDMEMEREDWYELLRAGR 299
Cdd:PRK10376 247 QRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDGIAR 288
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
24-294 |
5.54e-06 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 47.14 E-value: 5.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 24 LTDWSYTPRERLGLFEQMLDLGVTTFDLADIYGDyrcEQAFGEALK----LNPVLRERMEIVSKCSIrlagevSGARinh 99
Cdd:cd19155 17 LGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRN---EAAIGNVLKkwidSGKVKREELFIVTKLPP------GGNR--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 100 ydtsATHVRSAVETSLRDMGIEQMDLLLLHRP---------------------DPLMDADALAAVLEQLVAEGKVRQLGV 158
Cdd:cd19155 85 ----REKVEKFLLKSLEKLQLDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQVDQGLTRSIGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 159 SNYLPHQ-TDLLQSRLSQPlVANQIEVSL-LQSAPMfdgqLDYCQQHRVMPMAWSPFA--GGRLFRGDDGDAVRVQ---- 230
Cdd:cd19155 161 SNFNREQmARILKNARIKP-ANLQVELHVyLQQKDL----VDFCSTHSITVTAYAPLGspGAAHFSPGTGSPSGSSpdll 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2526794215 231 --QALHALCESRGLDPQvgamQLAVAWLLKHPAKMVPvlGSGNPERLVAALAALDMEMEREDWYEL 294
Cdd:cd19155 236 qdPVVKAIAERHGKSPA----QVLLRWLMQRGVVVIP--KSTNAARIKENFQVFDFELTEADMAKL 295
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
37-160 |
4.91e-05 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 44.43 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 37 LFEQMLDLGVTTFDLADIYGDYRCEQAFGEALKLNPvLRERMEIVSKCSIRL-AGEVSGARINHYdtSATHVRS---AVE 112
Cdd:cd19147 39 LLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRK-NRDQIVIATKFTTDYkAYEVGKGKAVNY--CGNHKRSlhvSVR 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2526794215 113 TSLRDMGIEQMDLLLLHRPDPLMDADALAAVLEQLVAEGKVRQLGVSN 160
Cdd:cd19147 116 DSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSD 163
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
42-212 |
1.03e-04 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 43.21 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 42 LDLGVTTFDLADiygDYRCEQAFGEA----LKLNPVLRERMEIVSKCsirlagevsgARINHydtSATHVRSAVETSLRD 117
Cdd:cd19129 29 LEAGFRHFDCAE---RYRNEAEVGEAmqevFKAGKIRREDLFVTTKL----------WNTNH---RPERVKPAFEASLKR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 118 MGIEQMDLLLLHRP---------DPlmdADALAAV--------------LEQLVAEGKVRQLGVSnylphqtDLLQSRLS 174
Cdd:cd19129 93 LQLDYLDLYLIHTPfafqpgdeqDP---RDANGNViyddgvtlldtwraMERLVDEGRCKAIGLS-------DVSLEKLR 162
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2526794215 175 QPLVANQIEVSLLQ--SAPMFDGQ--LDYCQQHRVMPMAWSP 212
Cdd:cd19129 163 EIFEAARIKPAVVQveSHPYLPEWelLDFCKNHGIVLQAFAP 204
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
107-211 |
6.18e-04 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 40.68 E-value: 6.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2526794215 107 VRSAVETSLRDMGIEQMDLLLLHRPDPLMDADALAAV-------------------LEQLVAEGKVRQLGVSNYLPHQtd 167
Cdd:cd19108 90 VRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKdengklifdtvdlcatweaMEKCKDAGLAKSIGVSNFNRRQ-- 167
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2526794215 168 lLQSRLSQP-----LVANQIE--VSLLQSApmfdgQLDYCQQHRVMPMAWS 211
Cdd:cd19108 168 -LEMILNKPglkykPVCNQVEchPYLNQSK-----LLDFCKSKDIVLVAYS 212
|
|
| |
