|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-587 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1016.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 1 MSNIDLKRRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRL 80
Cdd:PRK06354 1 MSLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 81 GRFKDGPVKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLLECLVTVGGVLSN 160
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 161 NKGVNFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLI-NKNGHSTPVVAKIEKFEAIDQIDTVL 239
Cdd:PRK06354 161 KKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 240 PLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNE 319
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 320 TAVGDYPVEAVQTMATIARRIERDYPLKAIESNLA---STIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPP 396
Cdd:PRK06354 321 TAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPeftTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 397 TPILATTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKVGLVRK 476
Cdd:PRK06354 401 TPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 477 IVSRGISIGEIGVTGKARIIKTNLDLSLICPGEILFVPKELLESLPLSNNIAGIVTNKTVNEVYSLFNKKNKKISAICNV 556
Cdd:PRK06354 481 VVAKGQGIGRKSVSGKARVAKTAAEVAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580 590
....*....|....*....|....*....|.
gi 2527226681 557 EIIDDyQIQNGDIVTLQLNEGVIYMGQIEDD 587
Cdd:PRK06354 561 KNATS-LIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 757.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDtkSNLLECLVTVGGVLSNNKGVNFP 167
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 168 DVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLCDGVMV 247
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 248 ARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPV 327
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 328 EAVQTMATIARRIERDYPLKAIESNLA----STIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATT 403
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRdepeRTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2527226681 404 TERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKV 468
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
8-471 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVLTSN--EVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSnlLECLVTVGGVLSNNKGVN 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 166 FPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHS-TPVVAKIEKFEAIDQIDTVLPLCDG 244
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 245 VMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGD 324
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 325 YPVEAVQTMATIARRIER------DYPLKAIESNLASTIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTP 398
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKalayltNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2527226681 399 ILATTTERSVARRLQLVWGVTPIVV-KNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKV 471
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-474 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 520.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDG- 86
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 87 PVKVKKGDKFVLTSNE--VDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLlECLVTVGGVLSNNKGV 164
Cdd:cd00288 82 DISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTL-VCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 165 NFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLCDG 244
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 245 VMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGD 324
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 325 YPVEAVQTMATIARRIER---DYPLKAIESNLAS---TIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTP 398
Cdd:cd00288 321 YPVEAVKAMARICLEAEKalsHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 399 ILATTTERSVARRLQLVWGVTPIVVK-----NDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGiSGSTDLIKVGL 473
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILT 479
|
.
gi 2527226681 474 V 474
Cdd:cd00288 480 V 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-341 |
7.21e-141 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 412.53 E-value: 7.21e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDG- 86
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 87 -PVKVKKGDKFVLTSNEV---DCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLlECLVTVGGVLSNNK 162
Cdd:pfam00224 82 kDIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTL-VVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 163 GVNFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLC 242
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 243 DGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAV 322
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330
....*....|....*....
gi 2527226681 323 GDYPVEAVQTMATIARRIE 341
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-587 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1016.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 1 MSNIDLKRRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRL 80
Cdd:PRK06354 1 MSLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 81 GRFKDGPVKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLLECLVTVGGVLSN 160
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 161 NKGVNFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLI-NKNGHSTPVVAKIEKFEAIDQIDTVL 239
Cdd:PRK06354 161 KKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 240 PLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNE 319
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 320 TAVGDYPVEAVQTMATIARRIERDYPLKAIESNLA---STIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPP 396
Cdd:PRK06354 321 TAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPeftTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 397 TPILATTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKVGLVRK 476
Cdd:PRK06354 401 TPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 477 IVSRGISIGEIGVTGKARIIKTNLDLSLICPGEILFVPKELLESLPLSNNIAGIVTNKTVNEVYSLFNKKNKKISAICNV 556
Cdd:PRK06354 481 VVAKGQGIGRKSVSGKARVAKTAAEVAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580 590
....*....|....*....|....*....|.
gi 2527226681 557 EIIDDyQIQNGDIVTLQLNEGVIYMGQIEDD 587
Cdd:PRK06354 561 KNATS-LIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 757.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDtkSNLLECLVTVGGVLSNNKGVNFP 167
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 168 DVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLCDGVMV 247
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 248 ARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPV 327
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 328 EAVQTMATIARRIERDYPLKAIESNLA----STIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATT 403
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRdepeRTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2527226681 404 TERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKV 468
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
8-464 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 591.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVL-TSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTksNLLECLVTVGGVLSNNKGVNF 166
Cdd:PRK05826 84 ITLKTGDKFTLdTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDG--DEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 167 PDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNG-HSTPVVAKIEKFEAIDQIDTVLPLCDGV 245
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 246 MVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDY 325
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 326 PVEAVQTMATIARRIE--RDYPLKAIESNLA-STIPNAISAAVSNIARQL-DAGAIISLTKSGSTARNVSKFRPPTPILA 401
Cdd:PRK05826 322 PVEAVEAMARICKGAEkeFSINLSKHRLDRQfDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIFA 401
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527226681 402 TTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISG 464
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
8-474 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 591.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDtkSNLLECLVTVGGVLSNNKGVNFP 167
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACD--GDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 168 DVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLInknGHSTPVVAKIEKFEAIDQIDTVLPLCDGVMV 247
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAIDRLEAIVEASDAIMV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 248 ARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPV 327
Cdd:PRK06247 240 ARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 328 EAVQTMATIARRIERD--YP--LKAIESNLASTIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATT 403
Cdd:PRK06247 320 EAVRTMARIIRQVERDptYPplIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALT 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2527226681 404 TERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKVGLV 474
Cdd:PRK06247 400 PNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
8-471 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 VKVKKGDKFVLTSN--EVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSnlLECLVTVGGVLSNNKGVN 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 166 FPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHS-TPVVAKIEKFEAIDQIDTVLPLCDG 244
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 245 VMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGD 324
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 325 YPVEAVQTMATIARRIER------DYPLKAIESNLASTIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTP 398
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKalayltNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2527226681 399 ILATTTERSVARRLQLVWGVTPIVV-KNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKV 471
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-474 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 520.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDG- 86
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 87 PVKVKKGDKFVLTSNE--VDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLlECLVTVGGVLSNNKGV 164
Cdd:cd00288 82 DISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTL-VCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 165 NFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLCDG 244
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 245 VMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGD 324
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 325 YPVEAVQTMATIARRIER---DYPLKAIESNLAS---TIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTP 398
Cdd:cd00288 321 YPVEAVKAMARICLEAEKalsHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 399 ILATTTERSVARRLQLVWGVTPIVVK-----NDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGiSGSTDLIKVGL 473
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILT 479
|
.
gi 2527226681 474 V 474
Cdd:cd00288 480 V 480
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
8-474 |
3.63e-161 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 469.15 E-value: 3.63e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGP 87
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 -VKVKKGDKFVLTSN-EVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVdtKSNLLECLVTVGGVLSNNKGVN 165
Cdd:PRK09206 82 dVSLKAGQTFTFTTDkSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI--TGNEVICKVLNNGDLGENKGVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 166 FPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKN-GHSTPVVAKIEKFEAIDQIDTVLPLCDG 244
Cdd:PRK09206 160 LPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFDEILEASDG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 245 VMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGD 324
Cdd:PRK09206 240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 325 YPVEAVQTMATIARRIERDYPLKaIESNLAS---TIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILA 401
Cdd:PRK09206 320 YPLEAVSIMATICERTDRVMNSR-LESNNDNrklRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527226681 402 TTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTgISGSTDLIKVGLV 474
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-341 |
7.21e-141 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 412.53 E-value: 7.21e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDG- 86
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 87 -PVKVKKGDKFVLTSNEV---DCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLlECLVTVGGVLSNNK 162
Cdd:pfam00224 82 kDIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTL-VVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 163 GVNFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLC 242
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 243 DGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAV 322
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330
....*....|....*....
gi 2527226681 323 GDYPVEAVQTMATIARRIE 341
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-453 |
3.72e-132 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 396.27 E-value: 3.72e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 2 SNIDLKRRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLG 81
Cdd:PLN02461 15 ADGLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 82 RFKDG-PVKVKKGDKFVLT---SNEVDcSNSIAnVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLLECLVTVGGV 157
Cdd:PLN02461 95 FLKDGkPVQLKQGQEITITtdySIKGD-ENMIA-MSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAM 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 158 LSNNKGVNFPDVKLSVKALTDKDKED-LKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQID 236
Cdd:PLN02461 173 LGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFD 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 237 TVLPLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVML 316
Cdd:PLN02461 253 DILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVML 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 317 SNETAVGDYPVEAVQTMATIARRIER--DY-------------PLKAIESnLASTipnaisaAVSNiARQLDAGAIISLT 381
Cdd:PLN02461 333 SGETAAGAYPELAVKTMARICREAEAslDYgalfkeimrsaplPMSPLES-LASS-------AVRT-ANKVKASLIVVLT 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 382 KSGSTARNVSKFRPPTPILA-------------TTTERSVARRLQLVWGVTPIVVK------NDERTAKTFSLAMQKAQE 442
Cdd:PLN02461 404 RGGTTARLVAKYRPAVPILSvvvpeittdsfdwSCSDEAPARHSLIYRGLIPVLAEgsakatDSESTEEILEAAIEHAKK 483
|
490
....*....|.
gi 2527226681 443 MGFLNQGDLVV 453
Cdd:PLN02461 484 KGLCKPGDSVV 494
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
1-471 |
3.24e-121 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 368.32 E-value: 3.24e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 1 MSNIDLK-RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNL-DLDIGILQDLQGPKI 78
Cdd:PTZ00066 30 ISDNDLRqKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 79 RLGRFKDG-PVKVKKGDKFVLTSN-EVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEmiVEKVDTKSNLLECLVTVGG 156
Cdd:PTZ00066 110 RTGFLKNHkPITLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLS--CKVLEVHDDYIITKVLNNA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 157 VLSNNKGVNFPDVKLSVKALTDKDKED-LKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQI 235
Cdd:PTZ00066 188 TIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 236 DTVLPLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVM 315
Cdd:PTZ00066 268 DEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVM 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 316 LSNETAVGDYPVEAVQTMATIARRIER--DYPLKAIESNLAS----TIPNAISAAVSNIARQLDAGAIISLTKSGSTARN 389
Cdd:PTZ00066 348 LSGETANGKFPVEAVNIMAKICFEAETciDYRVLYHAIHLAVptpvSVQEAVARSAVETAEDINAKLIIALTETGNTARL 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 390 VSKFRPPTPILATTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLI 469
Cdd:PTZ00066 428 ISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLM 507
|
..
gi 2527226681 470 KV 471
Cdd:PTZ00066 508 KV 509
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-475 |
3.57e-108 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 336.90 E-value: 3.57e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 2 SNIDLKRRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQV-SKNLDLDIGILQDLQGPKIRL 80
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYnAQSKDNVIAIMLDTKGPEVRS 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 81 GRFKDgPVKVKKGDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVeKVDTkSNLLECLVTVGGVLSN 160
Cdd:PLN02623 184 GDLPQ-PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAV-KSKT-SDSVKCEVVDGGELKS 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 161 NKGVNFPDVKLSVKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLP 240
Cdd:PLN02623 261 RRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIIT 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 241 LCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNET 320
Cdd:PLN02623 341 ASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGET 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 321 AVGDYPVEAVQTMATIARRIERDYPLKAIESNLASTIPNAIS---AAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPT 397
Cdd:PLN02623 421 AHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSemfAFHATMMANTLGTSIIVFTRTGFMAILLSHYRPSG 500
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 398 PILATTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQKAQEMGFLNQGDLV--VQTAGTLTGISGSTDLIKVGLVR 475
Cdd:PLN02623 501 TIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEValVQSGRQPIWRSESTHHIQVRKVQ 580
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
13-345 |
1.04e-106 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 325.36 E-value: 1.04e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 13 VATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIrqvsKNLDLDIGILQDLQGPKIRLGRFKDGPVKVKK 92
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLV----KSLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 93 GDKFVLTSNEVDCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSnlLECLVTVGGVLSNNKGVNFPDVKLS 172
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDK--IETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 173 VKALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKNGHSTP-VVAKIEKFEAIDQIDTVLPLCDGVMVARGD 251
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPnLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 252 LGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPVEAVQ 331
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|....*..
gi 2527226681 332 TMATI---ARRIERDYP 345
Cdd:PRK06739 320 TLRLVsefAEHVKKDGP 336
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
38-453 |
2.93e-103 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 320.07 E-value: 2.93e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 38 RLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGPVKVKKGDKFVLTSNEVDCSNSIAN---VTY 114
Cdd:PTZ00300 5 RMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFADKGTKDkfyIDY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 115 EKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLlECLVTVGGVLSNNKGVNFPDVKLSVKALTDKDKEDLKFGLSQGVDW 194
Cdd:PTZ00300 85 QNLSKVVRPGGYIYIDDGILILHVQSHEDEQTL-KCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVDM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 195 IALSFVRNPSDINEIKDLINKNGHSTPVVAKIEKFEAIDQIDTVLPLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANS 274
Cdd:PTZ00300 164 IFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 275 LGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPVEAVQTMATI---ARRIERDY----PLK 347
Cdd:PTZ00300 244 AGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIcleAQSAVNEYvffnSIK 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 348 AIESnLASTIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATTTERSVARRLQLVWGVTPIV----- 422
Cdd:PTZ00300 324 KLQP-IPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFfdaer 402
|
410 420 430
....*....|....*....|....*....|.
gi 2527226681 423 VKNDERTAKTFSLAMQKAQEMGFLNQGDLVV 453
Cdd:PTZ00300 403 LGHDEGKEQRVAMGVGFAKSKGYVQSGDLMV 433
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
271-585 |
1.07e-92 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 287.95 E-value: 1.07e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 271 KANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGDYPVEAVQTMATIARRIERDYPLKAIE 350
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 351 SNLAS----TIPNAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATTTERSVARRLQLVWGVTPIVVKND 426
Cdd:COG3848 81 VPRAKesstTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 427 ERTAKTFSLAMQKAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKVGLVRKIVSRGISIGEIGVTGKARIIKT-NLDLSLI 505
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSaEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 506 CPGEILFVP---KELLESLPlsnNIAGIVTnktvnEVYSLFN-----KKNKKISAICNVEIIDDyQIQNGDIVTLQLNEG 577
Cdd:COG3848 241 EEGDILVVPstdAEFVPAIE---KAAGIIT-----EEGGLTShaaivGLELGIPVIVGAEGATE-ILKDGQVVTVDAERG 311
|
....*...
gi 2527226681 578 VIYMGQIE 585
Cdd:COG3848 312 VVYRGAVN 319
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
8-453 |
5.93e-91 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 289.72 E-value: 5.93e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFkDGP 87
Cdd:PLN02762 25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL-GGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 88 --VKVKKGDKFVLTSNEVDCS--NSIANVTYEKLAQEVTKGKRILLDDGKIEM-IVEKVdtkSNLLECLVTVGGVLSNNK 162
Cdd:PLN02762 104 ssAKAEDGEEWTFTVRKFDGSrpEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKI---GPDVKCKCTDPGLLLPRA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 163 GVNF-PDVKLSVK------ALTDKDKEDLKFGLSQGVDWIALSFVRNPSDINEIKDLINKN--GHSTPVVAKIEKFEAID 233
Cdd:PLN02762 181 NLTFwRDGSLVRErnamlpTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLDSLK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 234 QIDTVLPLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDA 313
Cdd:PLN02762 261 NLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 314 VMLSNETAVGDYPVEAVQTMATIARRIER---------DYPLKAIESNLASTIPNAISAAVSNIARQLDAGAIISLTKSG 384
Cdd:PLN02762 341 LMLSGESAMGLYPEKALSVLRSVSLRMELwsreekrheALELPQLSSSLSDRISEEICNSAAKMANNLGVDAIFVYTKHG 420
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527226681 385 STARNVSKFRPPTPILATTTERSVARRLQLVWGVTPIVV--KND--ERTAKTFSLAMQKaqemGFLNQGDLVV 453
Cdd:PLN02762 421 HMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLdfSDDmeSNLNKTFSLLKAR----GMIKSGDLVI 489
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
10-453 |
1.48e-84 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 273.47 E-value: 1.48e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 10 TKIVATIGPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLGRFKDGPVK 89
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 90 VKKGDKFVLTSNE-VDCSNSIANVTYEKLAQEVTKGKRIL----LDDGKIEMIV--EKVDTKSNLLECLV----TVGGVL 158
Cdd:PLN02765 110 LKAGNTVTLTPDQsKEASSEVLPINFPGLAKAVKPGDTIFvgqyLFTGSETTSVwlEVDEVKGDDVVCTVknsaTLAGSL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 159 SNnkgVNFPDVKLSVKALTDKDKEDLK-FGLSQGVDWIALSFVRNPSDINEIKDLINKNG-HSTPVVAKIEKFEAIDQID 236
Cdd:PLN02765 190 FT---LHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 237 TVLPLCDGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITaTQMLDSMASNPRPTRAEVSDVANAILDGTDAVML 316
Cdd:PLN02765 267 EILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 317 SNETAVGDYPVEAVQTMATIARRIERDY---------------PLKAIESnLASTipnAISAAVsniarQLDAGAIISLT 381
Cdd:PLN02765 346 GAETLRGLYPVETISTVGRICAEAEKVFnqdlyfkktvkyvgePMSHLES-IASS---AVRAAI-----KVKASVIIVFT 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 382 KSGSTARNVSKFRPPTPILA-------------TTTERSVARRLQLVWGVTPIVVKNDERTAKTFS-------LAMQKAQ 441
Cdd:PLN02765 417 SSGRAARLIAKYRPTMPVLSvviprlktnqlkwSFTGAFQARQCLIVRGLFPMLADPRHSAESTSAtnesvlkVALDHGK 496
|
490
....*....|..
gi 2527226681 442 EMGFLNQGDLVV 453
Cdd:PLN02765 497 AAGVIKSHDRVV 508
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
8-342 |
4.72e-50 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 180.60 E-value: 4.72e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 8 RRTKIVATI-GPATQSEEIISDLIKAGVTTFRLNFSHGDHKDHEERIKTIRQVSKNLDLDIGILQDLQGPKIRLG--RFK 84
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGavAGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 85 DGPVKVKKGDKFVLT-------SNEVDCSnsiANVTYEKLAQEVTKGKRILLDDGKIEMIVEKVDTKSNLLEclVTV--- 154
Cdd:PRK08187 213 LGKTRLYTGDRLALVaqgpprrIDEEHFQ---VTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLE--VTHarp 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 155 GGV-LSNNKGVNFPDVKLSVKALTDKDKEDLKFgLSQGVDWIALSFVRNPSDINEIKD-LINKNGHSTP---VVAKIEKF 229
Cdd:PRK08187 288 KGLkLKPEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAaLAARRPDDWRklgLVLKIETP 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 230 EAIDQIDTVL-------PLcdGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDSMASNPRPTRAEVSD 302
Cdd:PRK08187 367 RAVANLPELIvqaagrqPF--GVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTD 444
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2527226681 303 VANAilDGTDAVMLSNetavGDYPVEAVQTMATIARRIER 342
Cdd:PRK08187 445 AAMA--ARAECVMLNK----GPYLVEAVTFLDDLLARMDG 478
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
75-342 |
1.04e-47 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 176.29 E-value: 1.04e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 75 GPKIRLGR----------FKDGPVKVKKGDKFVLTSNEV-------DCSNSIANVTYEKLAQEVTKGKRILLDDGKIEMI 137
Cdd:PRK14725 310 GTLLRLGRhdstrvgglpPVEQKLRLKVGDRLVLTRDDApgdpaqgDAPPARISCTLPEAFRAARVGERVWFDDGKIGAV 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 138 VEKVDTKSNLLECLVTVGG--VLSNNKGVNFPDVKLSVKALTDKDKEDLKFgLSQGVDWIALSFVRNPSDINEIKDLINK 215
Cdd:PRK14725 390 VVKVEADEVELRITHARPGgsKLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEK 468
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 216 NGHST-PVVAKIEKFEAIDQIDTVL------PLCdGVMVARGDLGVEMPAEEVPLLQKELIKKANSLGIPIITATQMLDS 288
Cdd:PRK14725 469 LGADDlGVVLKIETRRAFENLPRILleamrhPRF-GVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLES 547
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2527226681 289 MASNPRPTRAEVSDVANAILdgTDAVMLsNEtavGDYPVEAVQTMATIARRIER 342
Cdd:PRK14725 548 LAKKGLPSRAEITDAAMALR--AECVML-NK---GPHIVEAVRVLDDILRRMEE 595
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
359-471 |
4.75e-40 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 141.85 E-value: 4.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527226681 359 NAISAAVSNIARQLDAGAIISLTKSGSTARNVSKFRPPTPILATTTERSVARRLQLVWGVTPIVVKNDERTAKTFSLAMQ 438
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 2527226681 439 KAQEMGFLNQGDLVVQTAGTLTGISGSTDLIKV 471
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| |
