|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-734 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 1138.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGEDEA----LIHKITDRISMTGNERMTVEEIQDKVELELMKSPRKEV 76
Cdd:PRK07111 1 MMLYIVKRDGREVPFDEEKITNAIFKAAEAVGGELDESeaieLTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 77 AKRYIAYRDQRNIARRAKTRdmFLEIIEAKSNDITRENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYL 156
Cdd:PRK07111 81 AKAYILYRAERTRIREIKSD--LMKAIEEIGNDTDRENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHENGDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 157 HIHDKDYYPTkSLTCVQHPLDNILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSY 236
Cdd:PRK07111 159 HIHDLDFYNL-TTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAPFVEKTF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 237 VEEVKN-----VESLTGED------YSSLYEAPIDDYLKRPLDGLKGEERAKQHAINKTVGRVHQAMEAFIHNMNTIHSR 305
Cdd:PRK07111 238 RRHRKEileklLELGVGEEvdekesLNEEEELLLLLLALDFNIAKKAQEKADELAEKETRKRTYQAMEGFIHNLNTMHSR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 306 GGNQVVFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPN 385
Cdd:PRK07111 318 AGAQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKGETPIFPIQIFRVKEGVNYNEEDPNYDLFKLACRVAAKRLFPN 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 386 FVNLDATFNYhekwDINDPHRYRYEVATMGCRTRVFENRFGEKTSIGRGNLSFSTINIVRIAIECMSIVDKeerihrFFS 465
Cdd:PRK07111 398 FSFLDAPFNK----EYYDKGRPPTEVATMGCRTRVMSNVNGEEGTKGRGNLSFTTINLPRLAIEAKKDIDK------FFE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 466 KLDEVLEIAARQLCDRYDFQKTALAKQFPLLMS-RLWNGSENLKPNDTIESVINQGTLGIGFIGLAECLVALVGKHHGES 544
Cdd:PRK07111 468 LLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGqGLWKGSENLGPDDSIEPVLKQGTLGIGFIGLAETLVALTGKHHGES 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 545 EEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHK 624
Cdd:PRK07111 548 EEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYPISIFEK 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 625 AKVEAPYHELTRGGHIFYVEIDGDATHNPEAISDIVDLMDKYNIGYGSVNHNRNRCMTCGYEDAQEnlDECPKCGSHDID 704
Cdd:PRK07111 628 IEIEAPYHKLTNGGHISYVELDGDPSKNVEAFEIIVKAMKNTNIGYGSINHPVDRCPVCGYLGVIE--DKCPKCGSTNIQ 705
|
730 740 750
....*....|....*....|....*....|
gi 2527289036 705 KLQRITGYLvGTTDRWNNAKLAELNDRIVH 734
Cdd:PRK07111 706 RIRRITGYL-GTLDRFNSAKKAERRDRVKH 734
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-724 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 792.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGE-DEALIHKITDRI-----SMTGNERMTVEEIQDKVELELMKSPRK 74
Cdd:COG1328 1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDrDEELAEEIADEVekeleRLGGGGTITVEEIQDIVEKVLMESGHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 75 EVAKRYIAYRDQRNIARRAKTRDMF-LEIIEAKSNDITRENANMnTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRN 153
Cdd:COG1328 81 EVAKAYILYREQRTRLREARTTLVDdIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 154 GYLHIHDKDYYPTkSLTCVQHPLDNILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVR 233
Cdd:COG1328 160 GDIHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 234 ssyveevknvesltgedysslyeapiddylkrpldglkgeeraKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGnQVVFS 313
Cdd:COG1328 239 -------------------------------------------KDKLEGKTYKEIKQAMQSLEYNLNTLPSRRG-QTPFT 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 314 SINYGTDT----SAEGRCIIRELLNSTYEGVGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNL 389
Cdd:COG1328 275 SITFGLGTpedfSWEMRMINKAILEVRIEGDGEGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNY 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 390 DATFNYHEKwdindphryrYEVATMGCRTRVFENRFGEKTSIGRGNLSFSTINIVRIAIECMSivDKEErihrFFSKLDE 469
Cdd:COG1328 355 DNSDELYKG----------SFKRSMGCRLFLDGWENGEELNRGRGNLGVVTLNLPRIAYEAKG--DEEK----FFEILDE 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 470 VLEIAARQLCDRYDF-QKTALAKQFPLLM-SRLWNGseNLKPNDTIESVINQGTLGIGFIGLAECLVALVGKHHGESEEA 547
Cdd:COG1328 419 RLDLAKEALEIKRKRlQKLAKAGLAPILYqTGAYLG--RLKPDDSIDELFKNGFSTIGYIGLNEMLLNFTGKHHIESEEA 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 548 QALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKV 627
Cdd:COG1328 497 KAFALEILKHMRERADEWQEETGYLYSLYATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDF 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 628 EAPYHELTRGGHIFYVEIdGDATHNPEAISDIVD-LMDKYNIGYGSVNHNRNRCMTCGYEDaqENLDECPKCGSHD-IDK 705
Cdd:COG1328 577 EDEYQPLYTGGTISYVEL-GELQPNPEALEAVVRyAYDNYRIGYLGINPPFDICPKCGYLG--GEHDECPKCGNEDtVEV 653
|
730
....*....|....*....
gi 2527289036 706 LQRITGYLvGTTDRWNNAK 724
Cdd:COG1328 654 IRRTCGYL-GNVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
114-734 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 738.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 114 NANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSLTCVQHPLDNILKHGFTAGHGESRP 193
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 194 AKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYveevknvesltgedysslyeapiddylkrpldglkge 273
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDY------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 274 eraKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGNQVVFSSINYGTDTSAEGRC----IIRELLNSTYEGVGNGATAI-F 348
Cdd:pfam13597 124 ---EKHLKGLTYKEVKQAMQAFVYNLNTMPSRRGGQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFtF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 349 PIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNLDAtfnyhekwdiNDPHRYRYeVATMGCRTRVFeNRFGEK 428
Cdd:pfam13597 201 PIPIYKLKEGFNWDEGDPNYDLFELAFECTAKRGYPYFSNFDS----------DLLPGDGY-VASMGCRLRLD-LRPNRK 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 429 TSIG-RGNLSFSTINIVRIAIECMSivDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTALAKQ-FPLLMS-RLWNGSE 505
Cdd:pfam13597 269 RFGGlRGNIGVVTINLPRIAYEAAG--DEDK----FFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGeGYLRGGN 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 506 NlkpndtiesvinqgTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSG 585
Cdd:pfam13597 343 H--------------TLTIGFIGLNEALKALTGKHHGESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSY 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 586 KFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEIDgDATHNPEAISDIVDLMDK 665
Cdd:pfam13597 409 RFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVELG-EAQPNPEALEKLVRIAYD 487
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2527289036 666 YNIGYGSVNHNRNRCMTCGYEDAQEnldECPKCGSHD--IDKLQRITGYLVGTTDrWNNAKLAELNDRIVH 734
Cdd:pfam13597 488 TGIGYFSINPPIDVCPDCGYTGEIE---ECPNCGNHDekVEVIRRITGYLRPVSD-WNKGKQAELKDRVKH 554
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
112-734 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 603.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 112 RENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSLTCVQHPLDNILKHGFTAGHGES 191
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 192 RPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYVEEVKNVESLTGEDYSslyeapiddylkrpldglk 271
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFE------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 272 geerAKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGnQVVFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGATAIFPIQ 351
Cdd:TIGR02487 142 ----ATEYAARRTFTDVTQAMQGPEYNPNTLHSAGG-QTPFESIGYGTETSKEGRMIAKALLDVRMEGDGKGEPFIFPKI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 352 IWKKKRGVSYLPEDrNYDLYKLACKVTARRFFPNFVNLDATFNYHEKWdindphryryeVATMGCRTRVF--ENRFGEKT 429
Cdd:TIGR02487 217 IFKVREGFNWDEPD-PYDLFELAFECAAKRGYPYFLNLDPEDNVKEDV-----------RYPMGCRTFLSpnENGDGEES 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 430 SIGRGNLSFSTINIVRIAIEcmSIVDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTALAKQFPLLMS-RLWNGSENLk 508
Cdd:TIGR02487 285 YIGRGNIGVTSINLPRIAYK--SRGDEEE----FFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSqGGWDGGNLL- 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 509 pNDTIESVINQGTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFT 588
Cdd:TIGR02487 358 -DESVEEILKSGTNSIGFIGLNEALVALTGKHLHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFA 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 589 KADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEIDGdATHNPEAISDIVDLMDKYNI 668
Cdd:TIGR02487 437 KKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDE-AIPDPEALKDITKKAMKNGI 515
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2527289036 669 GYGSVNHNRNRCMTCGYEDAQENlDECPKCGSHDIDKLQRITGYLvGTTDRWNNAKLAELNDRIVH 734
Cdd:TIGR02487 516 GYFGINPPVDVCEDCGYTGEGLN-DKCPKCGSHDIEVISRITGYL-GPVENWNDGKQAEFKDRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
113-715 |
1.15e-180 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 526.86 E-value: 1.15e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 113 ENANMnTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSlTCVQHPLDNILKHGFTAGHGESR 192
Cdd:cd01675 1 ENANV-DSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLTP-YCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 193 PAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYVEevknvesltgedysslyeapiddylkrpldglkg 272
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLK---------------------------------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 273 eerakqHAINKTVGRVHQAMEAFIHNMNTiHSRGGNQVVFSSINYG-------------------TDTSAEGRCIIRELL 333
Cdd:cd01675 125 ------YRLTATRKEIKQAMQGFIYNLNT-LSRRGGQTPFTNITLGlvcpkdlefegggepvftyGDTDKEARMIQKAFL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 334 NSTYEGVGNGATAIFPIQIWKKKRGVSYLPedrNYDLYKLACKVTARRFFPNFVNLDATFNYHEkwdindphryryEVAT 413
Cdd:cd01675 198 EVRLEGDAKGRPFTFPIPTFNVTEGFNLDP---NYDLKELAFECAAKRGYPYFLNFDNSDNVPG------------DVRA 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 414 MGCRTRVFENR-----FGEKTSIGRGNLSFSTINIVRIAIEcmSIVDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTA 488
Cdd:cd01675 263 MGCRLFLDKNElkrggGLEGSGDGTGNIGVVTINLPRIAYE--ARGDEEK----FFELLDEYLELAKDALEIRRKRLKEA 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 489 LAKQFPLLMSR-LWNGSEnlkpndtiESVINQGTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSE 567
Cdd:cd01675 337 LARGLPPLYQEgLGGGKL--------LFILKRHTLTIGFIGLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKE 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 568 KYQHNFSVLATPAEGLSGKFTKADRKSFG-VLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEId 646
Cdd:cd01675 409 ETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIEL- 487
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2527289036 647 GDATHNPEAISDIVDLMDKYNIGYGSVNHNRNRCMTCGYEDAqENLDECPKCGSHDIDKLQRITGYLVG 715
Cdd:cd01675 488 GEAKPNPEALEALVKKAAKRGVIYFGINTPIDICNDCGYIGE-GEGFKCPKCGSEDVEVISRITGYLGP 555
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-734 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 1138.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGEDEA----LIHKITDRISMTGNERMTVEEIQDKVELELMKSPRKEV 76
Cdd:PRK07111 1 MMLYIVKRDGREVPFDEEKITNAIFKAAEAVGGELDESeaieLTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 77 AKRYIAYRDQRNIARRAKTRdmFLEIIEAKSNDITRENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYL 156
Cdd:PRK07111 81 AKAYILYRAERTRIREIKSD--LMKAIEEIGNDTDRENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHENGDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 157 HIHDKDYYPTkSLTCVQHPLDNILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSY 236
Cdd:PRK07111 159 HIHDLDFYNL-TTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAPFVEKTF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 237 VEEVKN-----VESLTGED------YSSLYEAPIDDYLKRPLDGLKGEERAKQHAINKTVGRVHQAMEAFIHNMNTIHSR 305
Cdd:PRK07111 238 RRHRKEileklLELGVGEEvdekesLNEEEELLLLLLALDFNIAKKAQEKADELAEKETRKRTYQAMEGFIHNLNTMHSR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 306 GGNQVVFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPN 385
Cdd:PRK07111 318 AGAQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKGETPIFPIQIFRVKEGVNYNEEDPNYDLFKLACRVAAKRLFPN 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 386 FVNLDATFNYhekwDINDPHRYRYEVATMGCRTRVFENRFGEKTSIGRGNLSFSTINIVRIAIECMSIVDKeerihrFFS 465
Cdd:PRK07111 398 FSFLDAPFNK----EYYDKGRPPTEVATMGCRTRVMSNVNGEEGTKGRGNLSFTTINLPRLAIEAKKDIDK------FFE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 466 KLDEVLEIAARQLCDRYDFQKTALAKQFPLLMS-RLWNGSENLKPNDTIESVINQGTLGIGFIGLAECLVALVGKHHGES 544
Cdd:PRK07111 468 LLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGqGLWKGSENLGPDDSIEPVLKQGTLGIGFIGLAETLVALTGKHHGES 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 545 EEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHK 624
Cdd:PRK07111 548 EEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYPISIFEK 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 625 AKVEAPYHELTRGGHIFYVEIDGDATHNPEAISDIVDLMDKYNIGYGSVNHNRNRCMTCGYEDAQEnlDECPKCGSHDID 704
Cdd:PRK07111 628 IEIEAPYHKLTNGGHISYVELDGDPSKNVEAFEIIVKAMKNTNIGYGSINHPVDRCPVCGYLGVIE--DKCPKCGSTNIQ 705
|
730 740 750
....*....|....*....|....*....|
gi 2527289036 705 KLQRITGYLvGTTDRWNNAKLAELNDRIVH 734
Cdd:PRK07111 706 RIRRITGYL-GTLDRFNSAKKAERRDRVKH 734
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-724 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 792.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGE-DEALIHKITDRI-----SMTGNERMTVEEIQDKVELELMKSPRK 74
Cdd:COG1328 1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDrDEELAEEIADEVekeleRLGGGGTITVEEIQDIVEKVLMESGHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 75 EVAKRYIAYRDQRNIARRAKTRDMF-LEIIEAKSNDITRENANMnTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRN 153
Cdd:COG1328 81 EVAKAYILYREQRTRLREARTTLVDdIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 154 GYLHIHDKDYYPTkSLTCVQHPLDNILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVR 233
Cdd:COG1328 160 GDIHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 234 ssyveevknvesltgedysslyeapiddylkrpldglkgeeraKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGnQVVFS 313
Cdd:COG1328 239 -------------------------------------------KDKLEGKTYKEIKQAMQSLEYNLNTLPSRRG-QTPFT 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 314 SINYGTDT----SAEGRCIIRELLNSTYEGVGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNL 389
Cdd:COG1328 275 SITFGLGTpedfSWEMRMINKAILEVRIEGDGEGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNY 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 390 DATFNYHEKwdindphryrYEVATMGCRTRVFENRFGEKTSIGRGNLSFSTINIVRIAIECMSivDKEErihrFFSKLDE 469
Cdd:COG1328 355 DNSDELYKG----------SFKRSMGCRLFLDGWENGEELNRGRGNLGVVTLNLPRIAYEAKG--DEEK----FFEILDE 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 470 VLEIAARQLCDRYDF-QKTALAKQFPLLM-SRLWNGseNLKPNDTIESVINQGTLGIGFIGLAECLVALVGKHHGESEEA 547
Cdd:COG1328 419 RLDLAKEALEIKRKRlQKLAKAGLAPILYqTGAYLG--RLKPDDSIDELFKNGFSTIGYIGLNEMLLNFTGKHHIESEEA 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 548 QALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKV 627
Cdd:COG1328 497 KAFALEILKHMRERADEWQEETGYLYSLYATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDF 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 628 EAPYHELTRGGHIFYVEIdGDATHNPEAISDIVD-LMDKYNIGYGSVNHNRNRCMTCGYEDaqENLDECPKCGSHD-IDK 705
Cdd:COG1328 577 EDEYQPLYTGGTISYVEL-GELQPNPEALEAVVRyAYDNYRIGYLGINPPFDICPKCGYLG--GEHDECPKCGNEDtVEV 653
|
730
....*....|....*....
gi 2527289036 706 LQRITGYLvGTTDRWNNAK 724
Cdd:COG1328 654 IRRTCGYL-GNVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
114-734 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 738.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 114 NANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSLTCVQHPLDNILKHGFTAGHGESRP 193
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 194 AKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYveevknvesltgedysslyeapiddylkrpldglkge 273
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDY------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 274 eraKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGNQVVFSSINYGTDTSAEGRC----IIRELLNSTYEGVGNGATAI-F 348
Cdd:pfam13597 124 ---EKHLKGLTYKEVKQAMQAFVYNLNTMPSRRGGQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFtF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 349 PIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNLDAtfnyhekwdiNDPHRYRYeVATMGCRTRVFeNRFGEK 428
Cdd:pfam13597 201 PIPIYKLKEGFNWDEGDPNYDLFELAFECTAKRGYPYFSNFDS----------DLLPGDGY-VASMGCRLRLD-LRPNRK 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 429 TSIG-RGNLSFSTINIVRIAIECMSivDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTALAKQ-FPLLMS-RLWNGSE 505
Cdd:pfam13597 269 RFGGlRGNIGVVTINLPRIAYEAAG--DEDK----FFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGeGYLRGGN 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 506 NlkpndtiesvinqgTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSG 585
Cdd:pfam13597 343 H--------------TLTIGFIGLNEALKALTGKHHGESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSY 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 586 KFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEIDgDATHNPEAISDIVDLMDK 665
Cdd:pfam13597 409 RFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVELG-EAQPNPEALEKLVRIAYD 487
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2527289036 666 YNIGYGSVNHNRNRCMTCGYEDAQEnldECPKCGSHD--IDKLQRITGYLVGTTDrWNNAKLAELNDRIVH 734
Cdd:pfam13597 488 TGIGYFSINPPIDVCPDCGYTGEIE---ECPNCGNHDekVEVIRRITGYLRPVSD-WNKGKQAELKDRVKH 554
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
98-735 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 736.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 98 MFLEIIEAKSNDITRENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSLTCVQHPLD 177
Cdd:PRK14704 14 VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDFYATGTTTCSQIPLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 178 NILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYVEEVKNVESLtgedysslyea 257
Cdd:PRK14704 94 QMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFDVDLAPYVRKTVERHKKRLQSY----------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 258 piddylkrPLDGLKGEERAKQHAINKTvgrvHQAMEAFIHNMNTIHSRGGNQVVFSSINYGTDTSAEGRCIIRELLNSTY 337
Cdd:PRK14704 163 --------PLTKEQIEEFAWKETENDT----YQACEAFIHNSNSMHSRGGGQVPFISINYGTDTSKEGRLLIKQLLKATQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 338 EGVGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNLDATFN--YHEKwdindphRYRYEVATMG 415
Cdd:PRK14704 231 AGLGKGETPIFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNavHYDG-------RPESEVCYMG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 416 CRTRVFENRFGEKTSIGRGNLSFSTINIVRIAIecMSivdkeERIHRFFSKLDEVLEIAARQLCDRYDFQKTALAKQFPL 495
Cdd:PRK14704 304 CRTRVMSNIHGEETAIGRGNLSFTSINLVKLAL--IS-----GSKEAFFEALNYYLDLGIKQLLERFEYQCTKRARDFRF 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 496 LMSR-LWNGSENLKPNDTIESVINQGTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFS 574
Cdd:PRK14704 377 LYSQgVWRGGEKLQPEDSVASILKQGTLSLGFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEHELNFS 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 575 VLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEIDGDATHNPE 654
Cdd:PRK14704 457 VIATPAEGLSGKFVKKDREEFGVISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKK 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 655 AISDIVDLMDKYNIGYGSVNHNRNRCMTCGYEDAQENldECPKCGS---HDIDKLQRITGYLVGTTDRWNNAKLAELNDR 731
Cdd:PRK14704 537 ALKQIVQAMAEHGVGYGSINHPVDRCKCCSYHGVIGN--ECPSCGNedeANIERIRRITGYLVGDMSKWNSAKRSEEMDR 614
|
....
gi 2527289036 732 IVHK 735
Cdd:PRK14704 615 VKHK 618
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
112-734 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 603.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 112 RENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSLTCVQHPLDNILKHGFTAGHGES 191
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 192 RPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYVEEVKNVESLTGEDYSslyeapiddylkrpldglk 271
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFE------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 272 geerAKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGnQVVFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGATAIFPIQ 351
Cdd:TIGR02487 142 ----ATEYAARRTFTDVTQAMQGPEYNPNTLHSAGG-QTPFESIGYGTETSKEGRMIAKALLDVRMEGDGKGEPFIFPKI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 352 IWKKKRGVSYLPEDrNYDLYKLACKVTARRFFPNFVNLDATFNYHEKWdindphryryeVATMGCRTRVF--ENRFGEKT 429
Cdd:TIGR02487 217 IFKVREGFNWDEPD-PYDLFELAFECAAKRGYPYFLNLDPEDNVKEDV-----------RYPMGCRTFLSpnENGDGEES 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 430 SIGRGNLSFSTINIVRIAIEcmSIVDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTALAKQFPLLMS-RLWNGSENLk 508
Cdd:TIGR02487 285 YIGRGNIGVTSINLPRIAYK--SRGDEEE----FFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSqGGWDGGNLL- 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 509 pNDTIESVINQGTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFT 588
Cdd:TIGR02487 358 -DESVEEILKSGTNSIGFIGLNEALVALTGKHLHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFA 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 589 KADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEIDGdATHNPEAISDIVDLMDKYNI 668
Cdd:TIGR02487 437 KKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDE-AIPDPEALKDITKKAMKNGI 515
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2527289036 669 GYGSVNHNRNRCMTCGYEDAQENlDECPKCGSHDIDKLQRITGYLvGTTDRWNNAKLAELNDRIVH 734
Cdd:TIGR02487 516 GYFGINPPVDVCEDCGYTGEGLN-DKCPKCGSHDIEVISRITGYL-GPVENWNDGKQAEFKDRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
113-715 |
1.15e-180 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 526.86 E-value: 1.15e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 113 ENANMnTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYLHIHDKDYYPTKSlTCVQHPLDNILKHGFTAGHGESR 192
Cdd:cd01675 1 ENANV-DSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLTP-YCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 193 PAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSSYVEevknvesltgedysslyeapiddylkrpldglkg 272
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLK---------------------------------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 273 eerakqHAINKTVGRVHQAMEAFIHNMNTiHSRGGNQVVFSSINYG-------------------TDTSAEGRCIIRELL 333
Cdd:cd01675 125 ------YRLTATRKEIKQAMQGFIYNLNT-LSRRGGQTPFTNITLGlvcpkdlefegggepvftyGDTDKEARMIQKAFL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 334 NSTYEGVGNGATAIFPIQIWKKKRGVSYLPedrNYDLYKLACKVTARRFFPNFVNLDATFNYHEkwdindphryryEVAT 413
Cdd:cd01675 198 EVRLEGDAKGRPFTFPIPTFNVTEGFNLDP---NYDLKELAFECAAKRGYPYFLNFDNSDNVPG------------DVRA 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 414 MGCRTRVFENR-----FGEKTSIGRGNLSFSTINIVRIAIEcmSIVDKEErihrFFSKLDEVLEIAARQLCDRYDFQKTA 488
Cdd:cd01675 263 MGCRLFLDKNElkrggGLEGSGDGTGNIGVVTINLPRIAYE--ARGDEEK----FFELLDEYLELAKDALEIRRKRLKEA 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 489 LAKQFPLLMSR-LWNGSEnlkpndtiESVINQGTLGIGFIGLAECLVALVGKHHGESEEAQALGLRIVSHMRSRANEFSE 567
Cdd:cd01675 337 LARGLPPLYQEgLGGGKL--------LFILKRHTLTIGFIGLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKE 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 568 KYQHNFSVLATPAEGLSGKFTKADRKSFG-VLPGITDKIYYTNSNHVPVYYHCSPRHKAKVEAPYHELTRGGHIFYVEId 646
Cdd:cd01675 409 ETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIEL- 487
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2527289036 647 GDATHNPEAISDIVDLMDKYNIGYGSVNHNRNRCMTCGYEDAqENLDECPKCGSHDIDKLQRITGYLVG 715
Cdd:cd01675 488 GEAKPNPEALEALVKKAAKRGVIYFGINTPIDICNDCGYIGE-GEGFKCPKCGSEDVEVISRITGYLGP 555
|
|
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-734 |
2.82e-143 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 436.23 E-value: 2.82e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEMgEDEALIHKITDRIS--MTGNERMTVEEIQDKVELELMKSPRKEVAK 78
Cdd:PRK09263 1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEV-DDEDYCATVAAEIAsrVEGRDEVDIEEIQDAVENQLMAGPYKALAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 79 RYIAYRDQRNIARRAKTR--DMFLEIIEAKSNDITRENANMNTDSPAGMMMKFASETTKPFVDDYLLSHEAREAVRNGYL 156
Cdd:PRK09263 80 AYIEYRHDRDIAREKATDlnEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGDI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 157 HIHDKDYYPTKSLT-CVQHPLDNILKHGFTAGHGESRPAKRIETAS-----IIGCISletaqNEMHGGQAIPAFDFYLAP 230
Cdd:PRK09263 160 HYHDLDYSPFFPMFnCCLIDLKGMLTNGFKIGNAEIESPKSIQTATavtaqIIAQVA-----SSQYGGCTINRIDEVLAP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 231 FVRSSYVEEVKNVESLTGEdysslyeapiddylkrpldglkgeERAKQHAINKTVGRVHQAMEAFIHNMNTIHSRGGnQV 310
Cdd:PRK09263 235 YAEKSYEKHLKDAEEWVIE------------------------EKAEAYARARTEKEIYDAMQSLEYEINTLHTSNG-QT 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 311 VFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGA-TAIFPIQIWKKKRGVSYLPEDRNYDLYKLACKVTARRFFPNFVNL 389
Cdd:PRK09263 290 PFVTLGFGLGTSWESRLIQKAILRNRIAGLGKERkTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNY 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 390 DATFNYHEKWdindphryryeVATMGCRT--RVFENRFGEKTSIGRGNLSFSTINIVRIAIEcmSIVDKEerihRFFSKL 467
Cdd:PRK09263 370 DKIVELTGSF-----------KTPMGCRSflQGWKDENGEEVHDGRNNLGVVTLNLPRIALE--AKGDED----KFWEIL 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 468 DEVLEIAARQLCDRYDFQKTALAKQFPLLmsrlW-NGS--ENLKPNDTIESVINQG--TLGIGFIGLAECLVALVGKHHG 542
Cdd:PRK09263 433 DERLELAKKALMTRIERLKGAKPRVAPIL----YmYGAfgVRLKADDDVDELFKNGraTISLGYIGLYETINALYGGSWE 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 543 ESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLPGITDKIYYTNSNHVPVYYHCSPR 622
Cdd:PRK09263 509 VNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPF 588
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 623 HKAKVEAPYHELTRGGHIFYVEIDgDATHNPEAISDIVDLMdkY-NIGYGSVNHNRNRCMTCGYE---DAQENLDECPKC 698
Cdd:PRK09263 589 EKLDFEKPYPPLASGGFIHYCEYP-NLQHNLKALEAVWDYS--YdRVGYLGTNTPIDECYECGFTgefECTEKGFTCPKC 665
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 2527289036 699 GSHDIDKL---QRITGYLvGTTDR--WNNAKLAELNDRIVH 734
Cdd:PRK09263 666 GNHDPKTVsvtRRTCGYL-GNPDArpFNHGRQEEIKRRVKH 705
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
1-710 |
5.17e-76 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 257.85 E-value: 5.17e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQTEmGEDEALIHKITDRI--SMTGNERMTVEEIQDKVELELMKSPRKEVAK 78
Cdd:PRK08270 1 MPTKIIKRDGRIVPFDAEKITEAIAKAFKATG-EFDPSEAERLALRVieKLEDEDIPSVEEIQDIVEKVLIEAGYFKTAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 79 RYIAYRDQRNIARRAKTrdMFLEIIEAKSNDITR------ENANMnTDSPAGMMMKFASETTKpfvdDYLLSH----EAR 148
Cdd:PRK08270 80 AYILYREQHARLRNDKK--TLLDVEDTVDEYLDRedwrvnENSNM-GYSLQGLILNISGKVTA----NYWLNKvyppEIG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 149 EAVRNGYLHIHDKDYYptkSLTCVQHPLDNILKHGFT--AGHGESRPAKRIETAsiIGCI--SLETAQNEMHGGQAIPAF 224
Cdd:PRK08270 153 EAHRNGDLHIHDLDML---SGYCAGWSLRDLLLEGFNgvPGKVESKPPKHFRSA--LGQIvnFLGTLQNEWAGAQAFSSF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 225 DFYLAPFVRssyveevknvesltgedysslyeapiddylkrpLDGLKGEErakqhainktvgrVHQAMEAFIHNMNTiHS 304
Cdd:PRK08270 228 DTYLAPFVR---------------------------------KDGLSYKE-------------VKQAIQEFVFNLNV-PS 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 305 RGGNQVVFSSInygT------DTSAEGRCII-RELLNSTY-------------------EGVGNGATAIFPIQiwkkkrg 358
Cdd:PRK08270 261 RWGFQTPFTNL---TfdltvpEDLKDQPVIIgGEEMDFTYgdfqkemdminrafievmlEGDANGRVFTFPIP------- 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 359 vSY-LPEDRNYD--LYKLACKVTARR---FFPNFVNLDAtfnyhekwdinDPHryryEVATMGCRTRVfENR-------- 424
Cdd:PRK08270 331 -TYnITKDFDWDseNADLLFEMTAKYglpYFQNFINSDL-----------KPE----DVRSMCCRLQL-DLRelrkrggg 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 425 -FG--EKT-SIGrgnlsFSTINIVRIAIECMsivDKEErihrFFSKLDEVLEIAarqlcdrydfqKTALAKQfpllmsRl 500
Cdd:PRK08270 394 lFGsaELTgSIG-----VVTINLPRLGYLSK---DEEE----FFARLDELMDLA-----------KDSLEIK------R- 443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 501 wngsenlkpnDTIESVINQGT-------LG--------IGFIGLAECLVALVGKHHGeSEEAQALGLRIVSHMRSRANEF 565
Cdd:PRK08270 444 ----------KVIERLTDKGLypytkryLGtlrnhfstIGLNGMNEACLNFLGKDIT-TEEGRAFALRVLDHMRERLVEF 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 566 SEKYQHNFSVLATPAEGLSGKFTKADRKSFgvlPGI-----TDKIYYTNSNHVPVYYHCSP----RHKAKVEAPYhelTr 636
Cdd:PRK08270 513 QEETGNLYNLEATPAEGTTYRLAKEDKKRY---PDIitagtDEEPYYTNSTQLPVGYTDDPfealELQDELQTKY---T- 585
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2527289036 637 GG---HIFYveidGDATHNPEAISDIV-DLMDKYNIGYGSVNHNRNRCMTCGYEDAQEnlDECPKCGShDIDKLQRIT 710
Cdd:PRK08270 586 GGtvfHLYL----GEAISDAEACKKLVkKALENYRLPYITITPTFSICPKHGYLSGEH--EFCPKCGE-ETEVYSRVV 656
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
93-731 |
1.17e-26 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 115.62 E-value: 1.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 93 AKTRDMFLEIIEAKSNDITrENANMNTdSPAGMMMKFASETTKPFVDDYLLShEAREAVRNGYLHIH---DKDYYPTksl 169
Cdd:PRK08579 7 MKKRDIIEEYAAWNSLDVN-ENANRYP-GPTGFFAYVLEEALKESLVSLLPE-PGLEAHFSGDIYIHklpYSLYIPY--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 170 tCVQHPLDNILKHGFTAGHGESRPAKRIETASIIGCISLETAQNEMHGGQAIPAFDFYLAPFVRSsyveevknvesltge 249
Cdd:PRK08579 81 -CTGHSISRLLEKGLKTPTIISRPARHFDTFVDHVANYLITMQHYFTGAQAFSSVEWYAGPFIRK--------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 250 dysslyeapiddylkrplDGLkGEERAKQHainktvgrvhqaMEAFIHNMNtIHSRGGNQVVFSSINYGTDTSA------ 323
Cdd:PRK08579 145 ------------------DGL-DYRKIKQN------------IQRLVYNLN-YPSRVGMQTPFTNFTVTLDAPKkmlegd 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 324 -----------------EGRCIIRELLNSTYEGVGNGATAIFPI--------QIWKKkrgvsylPEdrnydLYKLACKVT 378
Cdd:PRK08579 193 yavydgkkvgplgeyeeEAKLFLLALTEVLREGDALGQPFTFPIptlmttakMLWDD-------PE-----VFEAVFTTA 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 379 ARR--FF---PNFVNLDATFNYHEKWDInDPHRYRYEVATMGCRTRVFENRFGE---KTSIGR-----------GNLSFS 439
Cdd:PRK08579 261 AKRgsFYwlnTRVVDPDASYAMCCRINI-DKNELMYAFGVGGKSRRDLEDAEEEyleKLEKQRfgglwampditGSVNVT 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 440 TINIVRIAIECMSIVDKeerihrFFSKLDEVLEIAARQLC---DRYdfqkTALAKQFPLLMSRLWNGSENLkPNdtieSV 516
Cdd:PRK08579 340 TVNLPRIALEARGDDDK------FWELYEERLELVRITLDwfrERY----VKLLKTYPEMYSMIKEYLEEF-PS----SH 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 517 INQgtlgIGFIGLAECLVALVGK-------HHGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTK 589
Cdd:PRK08579 405 FNT----IGIIGLPEAAAIYLGEpklwtegSRRDWLEAAELMKKMVEFAVEKAREWMKETGTPWNVEEVPGESAAAKLAI 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 590 ADRKSF----GVLPGITDKIYytnSNHVPVYYHCSP-RHKAKVEAPYHELTRGG---HIFYVEidgdaTHNPEAISDIVD 661
Cdd:PRK08579 481 KDLKLFpelrEYLSDPENPIY---STSIAPYYGPLElWDRIEIEEKVQQEFTGGvmmHIFLGE-----EPDPEALAKLTK 552
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 662 LMDKYNIGYGSVNHNRNRCMTCGYEdAQENLDECPKCGSHDIDKLQRITGYLVGTTDrWNNAKLAELNDR 731
Cdd:PRK08579 553 RIMNTKLVYWSYTPAITVCNKCGRS-TTGLYTRCPRCGSEDVEVWSRIIGYYRPLKN-WNPYRKKEFWLR 620
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
5-89 |
2.16e-21 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 88.86 E-value: 2.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 5 VVKRDGRVVGYNDEKIKAAIRKAMLQTEMgEDEALIHKITDRISMTGNERMTVEEIQDKVELELMKSPRKEVAKRYIAYR 84
Cdd:pfam03477 3 VIKRDGRREPFDKEKIRRAIEKACEKSPD-QADELASEVEEELEKSLEDGISTEEIQDLVEKTLAEHPDYAVARAYILYR 81
|
....*
gi 2527289036 85 DQRNI 89
Cdd:pfam03477 82 NLRKE 86
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
114-714 |
2.65e-15 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 79.67 E-value: 2.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 114 NANMNTDSPAGMmmkFAsETTKPF---VDDYLLSHE---------AREAVR---NGYLHIHD----KDYyptksltCVQH 174
Cdd:PRK08271 59 NANVRHKNIATY---EA-ELMKDFfklINRYLVWNKikelfgkelADEYLRqieNHEIYVHDetslKPY-------CFSY 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 175 PLDNILKHGFTAGHGESRPAKRIEtaSIIGCIsLET---AQNEMHGGQAIPAFDFYLAPFVRSSYveevknvesltGEDY 251
Cdd:PRK08271 128 TMYPILEDGLTKIGGESKAPKHLS--SFCGSF-INFvfaVSSQFAGAVATVEFLVYFDYFARKDY-----------GDDY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 252 SSLYEAPIDDYLkrpldglkgeerakQHainktvgrvhqameaFIHNMNTIHSRGGNQVVFSSINYgtdtsaegrcIIRE 331
Cdd:PRK08271 194 LPTHRKEIENHL--------------QI---------------VVYSLNQPAAARGYQSVFWNISY----------YDRN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 332 LLNSTYEG--VGNGATAIFPIQIWKKKRGVSYLPEDRNYDLYKLACkVTARRFFPNFVNLD---ATFNYHEKWDINDPHR 406
Cdd:PRK08271 235 YFKAMFGGfvYPDGSTPNWEDIIALQKFFMEWFNKEREKAMLTFPV-VTAALLTDDGKCKDedfADFIAKENSKGNSFFI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 407 YRYEVA---TMGCRTRVFENRFGEKTSIGRGNL---SFS--TINIVRIAIECMSIVDkeerihrFFSKLDEVLE------ 472
Cdd:PRK08271 314 YISDSAdslASCCRLRNEISDNGFSYSLGAGGVntgSINviTINLPRIAQEARDRDD-------FLEILRERVDkihkyq 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 473 IAARQLCDR---------YDFQKTALAKQFpllmsrlwngsenlkpndtiesvinqGTLGIGfiGLAEcLVALVGKHHGE 543
Cdd:PRK08271 387 LAYREIMEEriaagmlplYDAGFISLDKQF--------------------------LTIGIN--GMVE-AAEFMGLTVGY 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 544 SEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRK-SFGV----------LPGIT-----DKIYY 607
Cdd:PRK08271 438 NEEYKDFVQEVLKVIYEANEKASKEYGFTFNTEFVPAENLGVKLAKWDREdGYGVprqcynsysyVVEDAntdalDKFKL 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 608 TNsnhvpvyyhcsprhkakveAPYHELTRGGHIFYVEIDgdATHNPEAISDIVDLMDKYNIGYGSVNHNRNRCMTCGYED 687
Cdd:PRK08271 518 HG-------------------KELDKYLSGGSALHLNLD--ERLSEEGYRKLLNIAAKTGCNYFAFNVKITICNDCHHID 576
|
650 660
....*....|....*....|....*..
gi 2527289036 688 aQENLDECPKCGSHDIDKLQRITGYLV 714
Cdd:PRK08271 577 -KRTGKRCPICGSENIDYYTRVIGYLK 602
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
1-94 |
2.70e-15 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 79.90 E-value: 2.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 1 MIQTVVKRDGRVVGYNDEKIKAAIRKAMLQT---EMGEDEALIHKITDRISmtGNERMTVEEIQDKVELELMKSPRK--- 74
Cdd:PRK06406 3 MVKEVIKRDGTVVPFDKKKIAMAIYKAMLSVkngSMEDAEELTDKVVERLK--KYERPTVEQIQDIVEKVLMTKKINgkd 80
|
90 100
....*....|....*....|..
gi 2527289036 75 --EVAKRYIAYRDQRNIARRAK 94
Cdd:PRK06406 81 ftDVAKSYILYREKRRKIREEK 102
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-141 |
6.22e-15 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 79.02 E-value: 6.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 5 VVKRDGRVVGYNDEKIKAAIRKAMLQTEMGEDEALIHKITDRISMTGNER------MTVEEIQDKVELELMKSPRKEVAK 78
Cdd:PRK12364 3 IIKRNGTTEPYDREKIEVAIRKAFASVGKPISDEIIYSLVAEVERFIKEKypnghnVSVEEIQDLVEKTLMEHGHYAEVK 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 79 RYIAYRDQRNIARRAKTR-------DMFLEIIEAKSNDITRENANMNTdspagMMMKFASeTTKPFVDDY 141
Cdd:PRK12364 83 SYILYRAQRTEKRKAREQiikffddDTVLGVLKEIQKDFPSDEYSLDL-----LAEKFLS-FCKPNMSEG 146
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-95 |
8.98e-15 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 78.47 E-value: 8.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 5 VVKRDGRVVGYNDEKIKAAIRKAMLQTEMGEDEA------LIHKITDRISMTGNERMT------VEEIQDKVELELMKSP 72
Cdd:PRK07207 36 VIRRNGSVVPFEPSKIAVAMTKAFLAVEGGQAAAsarvreTVEQLTEQVVRALVRRRPsggtfhIEDIQDQVELALMRSG 115
|
90 100
....*....|....*....|...
gi 2527289036 73 RKEVAKRYIAYRDQRNIARRAKT 95
Cdd:PRK07207 116 EHKVARAYVLYREKRAQERAAEA 138
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
2-96 |
1.24e-13 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 75.19 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 2 IQTVVKRDGRVVGYNDEKIKAAIRKAMLqtEMG-EDEALIHKITDRISMTGNERMT-----VEEIQDKVELELMKSPRKE 75
Cdd:PRK08332 3 VEKVMKRDGRIVPFDESRIRWAVQRAMW--EVGvRDEKKLDEVVKRIVQRINELYDgkiphIENIQDIVELELMRAGLFE 80
|
90 100
....*....|....*....|.
gi 2527289036 76 VAKRYIAYRDQRNIARRAKTR 96
Cdd:PRK08332 81 VAKAYILYRKKKAEIREEKKR 101
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-136 |
1.86e-11 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 67.66 E-value: 1.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 4 TVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGED----------EALIHKITDRISMTGNERMTV--EEIQDKVELELMKS 71
Cdd:PRK12365 119 SVIRRDGTVVHFNPMKISAALEKAFRATDKIEGmtpssvleeiNALTQNIVEEILECCSQEDRIdiEKIQDIVEQQLMVV 198
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2527289036 72 PRKEVAKRYIAYRDQRNIARRAKTRDMFLE-IIEAKSNDITRENANMNTDSPAGMMMKFA------SETTKP 136
Cdd:PRK12365 199 GHYDVAKNYILYREARARVRDNKEEDGSTEkTIAEEAYEVLSKDGSTYTMTKSQLLAHFAwacsrfPETTDA 270
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-95 |
3.00e-09 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 60.73 E-value: 3.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 4 TVVKRDGRVVGYNDEKIKAAIRKAMLQTEMGED--------EALIHKITDRI------SMTGNERMTVEEIQDKVELELM 69
Cdd:PRK12365 10 TIVKRNGMFVPFNQNRIFQALEAAFRDTRSLEDhsplpedlESSIRSITHQVvkevvqKITEGQVVTVERIQDMVESQLY 89
|
90 100
....*....|....*....|....*.
gi 2527289036 70 KSPRKEVAKRYIAYRDQRNiARRAKT 95
Cdd:PRK12365 90 VNGLQDVARDYIVYRDDRK-AHRKKS 114
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
148-650 |
3.58e-08 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 56.39 E-value: 3.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 148 REAVRNGYLHIHDKDYYPTkslTCVQHPLDNILKHGFtagHGESRPAKRIETAsiIGCISLETAQNEMH---GGQAIPAF 224
Cdd:cd00576 5 YEAVKSGVITVGRPDLPFT---GCVLVDYGDSLDPGI---KGVNETAKSINEA--IQKTYQIIALAASNqngGGVSFARA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 225 DFYLAPfvrssYVEEVKNVESLTGEDYSSLYeapiddylkrpldglkgeerakqHAINKTVGRVHQameafihnmntihs 304
Cdd:cd00576 77 SSILSP-----YGSRDYAKGSGTETDAVEAA-----------------------DAFNLALKEVGQ-------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 305 rGGNQVVFSSINYGTDTSAEGRCIIRELLNSTYEGVGNGATAIFP---IQIWKKKrgvsYLPEDRNYDLYKLACKVTARR 381
Cdd:cd00576 115 -GNGRTGAATGFIGGVHKGKGDKISQEFLNLALANGGEGIPLNFPnlsVRVSSDK----PGILVKAVELKQLIAEEARKT 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 382 FFPNFVNLDATFnyhekwdindphryryevatmgcrtrvfenrfgektsigrgnlsFSTINIVRIAiecmsivdkEERIH 461
Cdd:cd00576 190 GSPGIFNDELCN--------------------------------------------LVSLNLARIM---------EKAIN 216
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 462 RFFSKLDEVLEIAArQLCDRYDFQKTalakqfpllmsrlwngSENLKPNDTIESVINQ-GTLGIGFIGLAEcLVALVGKH 540
Cdd:cd00576 217 GSMDVVLEELEELA-FLAVRALDCVI----------------DSHDERIPTIELGGDErRTVGLGIAGVAD-LLIKLGLE 278
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527289036 541 HGESEEAQALGLRIVSHMRSRANEFSEKYQHNFSVLATPAEGLSGKFTKADRKSFGVLpgitdkIYYTNSNHVPvyyhcS 620
Cdd:cd00576 279 KVGDPEADDLAAELVDQLKKHLVKATNERGFNFLLGLSPSESNSSGAPATNGVSPSRG------*IAIVLNGDI-----G 347
|
490 500 510
....*....|....*....|....*....|
gi 2527289036 621 PRHKAKVEAPYHELTRGGHIFYVEIDGDAT 650
Cdd:cd00576 348 PEESLASVAILQFYADNGISDTITIPDSAT 377
|
|
| HybF |
COG0375 |
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion ... |
679-704 |
5.72e-04 |
|
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440144 Cd Length: 113 Bit Score: 40.15 E-value: 5.72e-04
10 20
....*....|....*....|....*..
gi 2527289036 679 RCMTCGYE-DAQENLDECPKCGSHDID 704
Cdd:COG0375 72 RCRDCGKEfELEELFLRCPKCGSPDLE 98
|
|
| NrdR |
COG1327 |
Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription]; |
4-81 |
2.04e-03 |
|
Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription];
Pssm-ID: 440938 [Multi-domain] Cd Length: 153 Bit Score: 39.29 E-value: 2.04e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2527289036 4 TVVKRDGRVVGYNDEKIKAAIRKAMlqtemgedealiHKitdR-ISMTgnermTVEEIQDKVELELMKSPRKEVAKRYI 81
Cdd:COG1327 50 MVIKKDGRREPFDREKLLRGLLRAC------------EK---RpVSAE-----QIEAAVDRIERELRASGEREVPSREI 108
|
|
| HypA |
pfam01155 |
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ... |
679-704 |
4.26e-03 |
|
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.
Pssm-ID: 460085 Cd Length: 111 Bit Score: 37.50 E-value: 4.26e-03
10 20
....*....|....*....|....*..
gi 2527289036 679 RCMTCGYE-DAQENLDECPKCGSHDID 704
Cdd:pfam01155 71 RCRDCGKEfELEERDLVCPRCGSPDVE 97
|
|
| |
