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Conserved domains on  [gi|2527390475|ref|WP_288408601|]
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class II aldolase/adducin family protein [uncultured Acinetobacter sp.]

Protein Classification

class II aldolase/adducin family protein( domain architecture ID 10012869)

class II aldolase/adducin family protein similar to L-fuculose phosphate aldolase, which catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 8-251 6.90e-132

aldolase II superfamily protein; Provisional


:

Pssm-ID: 235916  Cd Length: 252  Bit Score: 372.26  E-value: 6.90e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   8 SHMNPVEWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsyDQGKK 87
Cdd:PRK07044    8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  88 VNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIGYHNYEGIALSLDEQQRLVSDLGTHR 167
Cdd:PRK07044   86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 168 CMILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSS-SELNLPDIEVCRHTAAQFNRKEVEPIIQDAWQAALSLIEH 246
Cdd:PRK07044  166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGgGELVLPPPEVAERTARQSLFDPGAGAGELAWPALLRKLDR 245


                  ....*
gi 2527390475 247 QQDEY 251
Cdd:PRK07044  246 IDPGY 250
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 8-251 6.90e-132

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 372.26  E-value: 6.90e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   8 SHMNPVEWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsyDQGKK 87
Cdd:PRK07044    8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  88 VNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIGYHNYEGIALSLDEQQRLVSDLGTHR 167
Cdd:PRK07044   86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 168 CMILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSS-SELNLPDIEVCRHTAAQFNRKEVEPIIQDAWQAALSLIEH 246
Cdd:PRK07044  166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGgGELVLPPPEVAERTARQSLFDPGAGAGELAWPALLRKLDR 245


                  ....*
gi 2527390475 247 QQDEY 251
Cdd:PRK07044  246 IDPGY 250
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 14-225 2.10e-72

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 220.09  E-value: 2.10e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  14 EWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGF 93
Cdd:COG0235     3 EEELREELAAAGRRLARRGLVDGTAGNISVRLDDD--RFLITPSGVDFGELTPEDLVVVDLDGNVVE----GDLKPSSET 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  94 VIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQ-HAFKFYEQIGYHNYEGIAlSLDEQQRLVSDLGTHRCMILR 172
Cdd:COG0235    77 PLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQtEAAAFLGDVPVVPYAGPG-TEELAEAIAEALGDRPAVLLR 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2527390475 173 NHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSELNLPDIEVCRHTAAQFN 225
Cdd:COG0235   156 NHGVVVWGKDLAEAFDRAEVLEEAARIQLLALALGGPLVLSDEEIDKLARKFG 208
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 19-201 5.44e-58

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 182.36  E-value: 5.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  19 CQLAALYRLIAYYRMTDLIDTHISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVESydqGKKVNAaGFVIHSA 98
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRLPGD--GFLITPSGVDFGELTPEDLVVVDLDGNVVEG---GLKPSS-ETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  99 IHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKF-YEQIGYHNYEGIAlSLDEQQRLVSDLGTHRC-MILRNHGL 176
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlGGDIPIIPYYTPG-TEELGERIAEALGGDRKaVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 2527390475 177 LATGDTLARAFHEIYFLERACQIQI 201
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 21-201 3.52e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 175.52  E-value: 3.52e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   21 LAALYRLIAYYRMTDLIDTHISLRVpDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDQGKkvNAAGFVIHSAIH 100
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGGPK--PSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  101 HARSDVNCIIHTHTADGVAVSAQKH--GLLPLSQHAFKFYEQIGYHNYEGIALSLDEQ-----QRLVSDLGTHRCMILRN 173
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALGKplPLLPTEQAAAFLGGEIPYAPYAGPGTELAEEgaelaEALAEALPDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 2527390475  174 HGLLATGDTLARAFHEIYFLERACQIQI 201
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 14-216 3.76e-37

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 129.79  E-value: 3.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  14 EWSARcQLAALYRLIAYYRMTDLIDTHISLRVPDEPcHFLINRYGIPFEKMTASNLVKIDHDGRIVESydqgkKVNAAGF 93
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSARDRDRG-YFLITPSGVDYEEMTASDLVVVDAQGKVVEG-----KKPSSET 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  94 VIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLS--QHAFKFYEQIGYHNYEGIALSLDEqQRLVSDLG--THRCM 169
Cdd:cd00398    74 PLHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGhtACAVYFTGDIPCTPYMTPETGEDE-IGTQRALGfpNSKAV 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2527390475 170 ILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSELNLPDIEV 216
Cdd:cd00398   153 LLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQLPPISLE 199
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 8-251 6.90e-132

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 372.26  E-value: 6.90e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   8 SHMNPVEWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsyDQGKK 87
Cdd:PRK07044    8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  88 VNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIGYHNYEGIALSLDEQQRLVSDLGTHR 167
Cdd:PRK07044   86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 168 CMILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSS-SELNLPDIEVCRHTAAQFNRKEVEPIIQDAWQAALSLIEH 246
Cdd:PRK07044  166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGgGELVLPPPEVAERTARQSLFDPGAGAGELAWPALLRKLDR 245


                  ....*
gi 2527390475 247 QQDEY 251
Cdd:PRK07044  246 IDPGY 250
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 14-225 2.10e-72

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 220.09  E-value: 2.10e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  14 EWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGF 93
Cdd:COG0235     3 EEELREELAAAGRRLARRGLVDGTAGNISVRLDDD--RFLITPSGVDFGELTPEDLVVVDLDGNVVE----GDLKPSSET 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  94 VIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQ-HAFKFYEQIGYHNYEGIAlSLDEQQRLVSDLGTHRCMILR 172
Cdd:COG0235    77 PLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQtEAAAFLGDVPVVPYAGPG-TEELAEAIAEALGDRPAVLLR 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2527390475 173 NHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSELNLPDIEVCRHTAAQFN 225
Cdd:COG0235   156 NHGVVVWGKDLAEAFDRAEVLEEAARIQLLALALGGPLVLSDEEIDKLARKFG 208
PRK06661 PRK06661
hypothetical protein; Provisional
 21-245 1.99e-58

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 185.42  E-value: 1.99e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  21 LAALYRLIAYYRMTDLIDTHISLRvPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKKV--NAAGFVIHSA 98
Cdd:PRK06661    7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILE----GEEYqyNKTGYFIHGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  99 IHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIGYHNYEGIALSLDEQ-QRLVSDLGTHRCMILRNHGLL 177
Cdd:PRK06661   82 IYKTRPDISAIFHYHTPASIAVSALKCGLLPISQWALHFYDRISYHNYNSLALDADKQsSRLVNDLKQNYVMLLRNHGAI 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 178 ATGDTLARAFHEIYFLERACQIQ--IKAMSSSELNLPDIEVCRHTAAQFNRKEvEPIIQDAWQAALSLIE 245
Cdd:PRK06661  162 TCGKTIHEAMFYTYHLEQACKTQclLNSTKKQELIIPSVEICKKTVKDLLSFE-EDLGKRDWAAWLRLIK 230
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 19-201 5.44e-58

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 182.36  E-value: 5.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  19 CQLAALYRLIAYYRMTDLIDTHISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVESydqGKKVNAaGFVIHSA 98
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRLPGD--GFLITPSGVDFGELTPEDLVVVDLDGNVVEG---GLKPSS-ETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  99 IHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKF-YEQIGYHNYEGIAlSLDEQQRLVSDLGTHRC-MILRNHGL 176
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlGGDIPIIPYYTPG-TEELGERIAEALGGDRKaVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 2527390475 177 LATGDTLARAFHEIYFLERACQIQI 201
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 21-201 3.52e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 175.52  E-value: 3.52e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   21 LAALYRLIAYYRMTDLIDTHISLRVpDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDQGKkvNAAGFVIHSAIH 100
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGGPK--PSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  101 HARSDVNCIIHTHTADGVAVSAQKH--GLLPLSQHAFKFYEQIGYHNYEGIALSLDEQ-----QRLVSDLGTHRCMILRN 173
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALGKplPLLPTEQAAAFLGGEIPYAPYAGPGTELAEEgaelaEALAEALPDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 2527390475  174 HGLLATGDTLARAFHEIYFLERACQIQI 201
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PRK06208 PRK06208
class II aldolase/adducin family protein;
20-223 7.43e-55

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 177.49  E-value: 7.43e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  20 QLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKK-VNAAGFVIHSA 98
Cdd:PRK06208   46 RLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE----GDRpLNRAAFAIHSA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  99 IHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIG-YHNYEGIALSLDEQQRLVSDLGTHRCMILRNHGLL 177
Cdd:PRK06208  122 IHEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDACAFYEDHAlFDDFTGVVVDTSEGRRIAAALGTHKAVILQNHGLL 201

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2527390475 178 ATGDTL-ARAFHEIYfLERACQIQIKAMSSSELNLPDIEVCRHTAAQ 223
Cdd:PRK06208  202 TVGPSVdAAAWWFIA-LERACQTQLLAEAAGPPQPIDHETARHTRSQ 247
PRK06486 PRK06486
aldolase;
15-223 2.88e-43

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 147.17  E-value: 2.88e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  15 WSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDQgkkVNAAGFV 94
Cdd:PRK06486   25 AQARVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEITASDLLICDFDGNVLAGRGE---PEATAFF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  95 IHSAIHHARSDVNCIIHTHTADGVAVS-AQKHGLLPLSQHAFKFYEQIGY-HNYEGIALSLDEQQRLVSDLGTHRCMILR 172
Cdd:PRK06486  102 IHARIHRAIPRAKAAFHTHMPYATALSlTEGRPLTTLGQTALKFYGRTAVdEDYNGLALDAAEGDRIARAMGDADIVFLK 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2527390475 173 NHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSELNLP-DIEVCRHTAAQ 223
Cdd:PRK06486  182 NHGVMVCGPRIAEAWDDLYYLERACEVQVLAMSTGRPLVPvDPAIAAAVARQ 233
PRK07490 PRK07490
hypothetical protein; Provisional
 14-223 3.24e-38

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 133.69  E-value: 3.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  14 EWSARCQLAALYRLIAYYRMTDLIDTHISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRivESYDQGKKVNAAGF 93
Cdd:PRK07490    8 EEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLDADDP--STAERPDVPDATAW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  94 VIHSAIHHARSDVNCIIHTHT--ADGVAVSAQKHgLLPLSQHAFKFYEQIGY-HNYEGIALSlDEQQRLVSDLGTHRCMI 170
Cdd:PRK07490   86 AIHGQIHRRLPHARCVMHVHSvyATALACLADPT-LPPIDQNTARFFNRVAVdTLYGGMALE-EEGERLAGLLGDKRRLL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2527390475 171 LRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSS-SELNLPDIEVCRHTAAQ 223
Cdd:PRK07490  164 MGNHGVLVTGDTVAEAFDDLYYFERACQTYITALSTgQPLRVLSDAVAEKTARD 217
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 14-216 3.76e-37

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 129.79  E-value: 3.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  14 EWSARcQLAALYRLIAYYRMTDLIDTHISLRVPDEPcHFLINRYGIPFEKMTASNLVKIDHDGRIVESydqgkKVNAAGF 93
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSARDRDRG-YFLITPSGVDYEEMTASDLVVVDAQGKVVEG-----KKPSSET 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  94 VIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLS--QHAFKFYEQIGYHNYEGIALSLDEqQRLVSDLG--THRCM 169
Cdd:cd00398    74 PLHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGhtACAVYFTGDIPCTPYMTPETGEDE-IGTQRALGfpNSKAV 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2527390475 170 ILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSELNLPDIEV 216
Cdd:cd00398   153 LLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQLPPISLE 199
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 8-209 8.07e-18

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 80.07  E-value: 8.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475   8 SHMNPVEWSARCQLAALYRLIAYYRMTDLIDTHISLRVPdEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVESydQGKK 87
Cdd:PRK07090   22 NELKDSGWTLRQKLALTCRILFDAGHDSGLAGQITARAE-APGTYYTQRLGLGFDEITASNLLLVDEDLNVLDG--EGMP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  88 VNAAGFviHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPLSQHAFKFYEQIGY-HNYEGIALSLDEQQRLVSDLGTH 166
Cdd:PRK07090   99 NPANRF--HSWIYRARPDVNCIIHTHPPHVAALSMLEVPLVVSHMDTCPLYDDCAFlKDWPGVPVGNEEGEIISAALGDK 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2527390475 167 RCMILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSEL 209
Cdd:PRK07090  177 RAILLSHHGQLVAGKSIEEACVLALLIERAARLQLLAMAAGPI 219
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
53-195 4.02e-10

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 57.83  E-value: 4.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  53 LINRYGIPFEKMTASNLVKIDHDGRivesYDQGKkVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGL----- 127
Cdd:PRK08087   39 LITPTGIPYEKLTESHIVFVDGNGK----HEEGK-LPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPIpaihy 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 128 ---------LPLSQHAFKFYEQIGYHNYEGIALSldeqqrlvsdlgthRCMILRNHGLLATGDTLARAF---HEIYFLER 195
Cdd:PRK08087  114 miaaaggnsIPCAPYATFGTRELSEHVALALKNR--------------KATLLQHHGLIACEVNLEKALwlaHEVEVLAQ 179
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
58-215 4.60e-08

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 52.06  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  58 GIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQK------HGLLPLS 131
Cdd:PRK06833   46 GIDYFEIKPEDIVIMDLDGKVVE----GERKPSSELDMHLIFYRNREDINAIVHTHSPYATTLACLGwelpavHYLIAVA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 132 QHAFKFYEqigYHNYEGIALSLDEQQRLVSdlgtHRCMILRNHGLLATGDTLARAFHEIYFLERACQIQIKAMSSSE-LN 210
Cdd:PRK06833  122 GPNVRCAE---YATFGTKELAENAFEAMED----RRAVLLANHGLLAGANNLKNAFNIAEEIEFCAEIYYQTKSIGEpKL 194


                  ....*
gi 2527390475 211 LPDIE 215
Cdd:PRK06833  195 LPEDE 199
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 41-194 1.84e-07

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 50.39  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  41 ISLRVPDEPcHFLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAV 120
Cdd:PRK06557   35 VSARDPGTD-LVVIKPSGVSYDDLTPEDMVVVDLDGNVVE----GDLKPSSDTASHLYVYRHMPDVGGVVHTHSTYATAW 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 121 SAQKHGlLP--LSQHAFKFYEQIGYHNYegiALSLDEQ--QRLVSDLGTHR--CMILRNHGLLATGDTLARAFHEIYFLE 194
Cdd:PRK06557  110 AARGEP-IPcvLTAMADEFGGPIPVGPF---ALIGDEAigKGIVETLKGGRspAVLMQNHGVFTIGKDAEDAVKAAVMVE 185
PRK08130 PRK08130
putative aldolase; Validated
 41-194 2.40e-07

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 49.87  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  41 ISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDQGKKVnaagfVIHSAIHHARSDVNCIIHTHTADGVAV 120
Cdd:PRK08130   30 ISARLDDG--GWLVTPTGSCLGRLDPARLSKVDADGNWLSGDKPSKEV-----PLHRAIYRNNPECGAVVHLHSTHLTAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 121 SAQ------------------KHGLLPLsqhafkfyeqIGYHNYEGIALSldeqqRLVSDL-GTHRCMILRNHGLLATGD 181
Cdd:PRK08130  103 SCLggldptnvlppftpyyvmRVGHVPL----------IPYYRPGDPAIA-----EALAGLaARYRAVLLANHGPVVWGS 167

                         170
                  ....*....|...
gi 2527390475 182 TLARAFHEIYFLE 194
Cdd:PRK08130  168 SLEAAVNATEELE 180
araD PRK13145
L-ribulose-5-phosphate 4-epimerase; Provisional
 52-215 2.86e-07

L-ribulose-5-phosphate 4-epimerase; Provisional


Pssm-ID: 183870 [Multi-domain]  Cd Length: 234  Bit Score: 49.83  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  52 FLINRYGIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAvSAQKHGLLPL- 130
Cdd:PRK13145   40 IVIKPSGVDYDELTPENMVVTDLDGNVVE----GDLNPSSDLPTHVELYKAWPEVGGIVHTHSTEAVG-WAQAGRDIPFy 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 131 -SQHAFKFYEQI------------GYHNYEGIALSLDEQQRLVSDLGTHRCMILRNHGLLATGDTLARAFHEIYFLERAC 197
Cdd:PRK13145  115 gTTHADYFYGPIpcarsltkdevnGAYEKETGSVIIEEFEKRGLDPMAVPGIVVRNHGPFTWGKNPEQAVYHSVVLEEVA 194

                         170
                  ....*....|....*...
gi 2527390475 198 qiqiKAMSSSELNLPDIE 215
Cdd:PRK13145  195 ----KMNRLTEQINPRVE 208
PRK05874 PRK05874
L-fuculose-phosphate aldolase; Validated
 40-231 3.64e-06

L-fuculose-phosphate aldolase; Validated


Pssm-ID: 102036 [Multi-domain]  Cd Length: 217  Bit Score: 46.56  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  40 HISLRVPDEpcHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDqgKKVNAAGFVIHSAIHHARSDVNCIIHTHTAdGVA 119
Cdd:PRK05874   30 NISARRSDG--NVVITPSSVDYAEMLLHDLVLVDAGGAVLHAKD--GRSPSTELNLHLACYRAFDDIGSVIHSHPV-WAT 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 120 VSAQKHGLLPLSQHAFKFYEQIGYHNYEGIALSLDEQQR-LVSDLGTHRCMILRNHGLLATGDTLARAFHEIYFLERACQ 198
Cdd:PRK05874  105 MFAVAHEPIPACIDEFAIYCGGDVRCTEYAASGTPEVGRnAVRALEGRAAALIANHGLVAVGPRPDQVLRVTALVERTAQ 184

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2527390475 199 IQIKAMS-SSELNLPDiEVCRHTAAQFNRKEVEP 231
Cdd:PRK05874  185 IVWGARAlGGPVPIPE-DVCRNFTGVYGYLRANP 217
PRK08660 PRK08660
aldolase;
41-199 3.73e-05

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 43.02  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  41 ISLRVPDEpchFLINRYGIPFEKMTASNLVKIDhdgriVESYDQGKKVNAAGFVIHSAIHhARSDVNCIIHTHTADGVAV 120
Cdd:PRK08660   25 ISVRTGDG---LLITRTGSMLDEITEGDVIEVG-----IDDDGSVDPLASSETPVHRAIY-RRTSAKAIVHAHPPYAVAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 121 SAQKHGLLPLSQHAFKFYEQI----GYHNYEGIAlsldeqQRLVSDLGTHRCMILRNHGLLATGDTLARAFHEIYFLERA 196
Cdd:PRK08660   96 SLLEDEIVPLDSEGLYFLGTIpvvgGDIGSGELA------ENVARALSEHKGVVVRGHGTFAIGKTLEEAYIYTSQLEHS 169


                  ...
gi 2527390475 197 CQI 199
Cdd:PRK08660  170 CKV 172
mtnB PRK06754
methylthioribulose 1-phosphate dehydratase;
41-116 7.50e-05

methylthioribulose 1-phosphate dehydratase;


Pssm-ID: 180679 [Multi-domain]  Cd Length: 208  Bit Score: 42.73  E-value: 7.50e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2527390475  41 ISLRVPDEPCHFLINRYGIPFEKMTASNLVKIDHDGRIVEsyDQGKKVNAAGfVIHSAIHHaRSDVNCIIHTHTAD 116
Cdd:PRK06754   31 LSIKVSDDPLTFLVTASGKDKRKTTPEDFLLVDHDGKPVE--ETELKPSAET-LLHTHIYN-NTNAGCVLHVHTVD 102
PRK08333 PRK08333
aldolase;
25-199 1.13e-03

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 39.04  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  25 YRLIAYYR------MTDLIDTHISLRVPDepcHFLINRYGIPFEKMTASNLVKIDHDGRIVESYDQGKKvnaagFVIHSA 98
Cdd:PRK08333    6 AQLVKYSKlahergLTAAFGGNLSIRVGN---LVFIKATGSVMDELTREQVAVIDLNGNQLSSVRPSSE-----YRLHLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  99 IHHARSDVNCIIHTHTADGVAVSAQKHGLLP-LSQHAFKFYEQIGYHNYEGiALSLDEQQRLVSDLGTHRCMILRNHGLL 177
Cdd:PRK08333   78 VYRNRPDVRAIAHLHPPYSIVASTLLEEELPiITPEAELYLKKIPILPFRP-AGSVELAEQVAEAMKEYDAVIMERHGIV 156

                         170       180
                  ....*....|....*....|..
gi 2527390475 178 ATGDTLARAFHEIYFLERACQI 199
Cdd:PRK08333  157 TVGRSLREAFYKAELVEESAKL 178
araD PRK08193
L-ribulose-5-phosphate 4-epimerase AraD;
58-141 7.07e-03

L-ribulose-5-phosphate 4-epimerase AraD;


Pssm-ID: 236181  Cd Length: 231  Bit Score: 36.74  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  58 GIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVSAQKHGLLPL-SQHAFK 136
Cdd:PRK08193   45 GVDYDKMTAEDMVVVDLEGNVVE----GKLKPSSDTPTHLVLYKAFPEIGGIVHTHSRHATAWAQAGRDIPALgTTHADY 120


                  ....*
gi 2527390475 137 FYEQI 141
Cdd:PRK08193  121 FYGDI 125
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 58-205 7.82e-03

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 36.70  E-value: 7.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475  58 GIPFEKMTASNLVKIDHDGRIVEsydqGKKVNAAGFVIHSAIHHARSDVNCIIHTHTADGVAVsAQKHGLLPL--SQHAF 135
Cdd:PRK12348   44 GVAYETMKADDMVVVDMSGKVVE----GEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAW-AQAGLAIPAlgTTHAD 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527390475 136 KFYEQIG----------YHNYEgialsLDEQQRLVSDLGTHR-----CMILRNHGLLATGDTLARAFHEIYFLERACQIQ 200
Cdd:PRK12348  119 YFFGDIPctrglseeevQGEYE-----LNTGKVIIETLGNAEplhtpGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMA 193


                  ....*
gi 2527390475 201 IKAMS 205
Cdd:PRK12348  194 WIARG 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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