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Conserved domains on  [gi|2528074342|ref|WP_289016611|]
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DUF4292 domain-containing protein [uncultured Culturomica sp.]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4292 super family cl16635
Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. ...
 33-263 4.35e-28

Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.


The actual alignment was detected with superfamily member pfam14125:

Pssm-ID: 464088  Cd Length: 208  Bit Score: 106.59  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342  33 YSKKVELSVDING-KENSLKGMLRIRRDSFIWMSVTAPLGIEVARIYLTPDSVKFLDSYNKKYLLTDYGFFYDRFGISIS 111
Cdd:pfam14125   4 LSGKAKVRLKTNGqKQVSLNVSIRMKKDEAIWLSAIPFLGIEVARALITPDSVLVYDRLNKRYFVGDYENLSKLLGIELS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342 112 FSCIQKILTNVYFNledcssSESRNDKFKFERTDNDYVLSNIQKRainrkikkffkkkrknkdfalVLQKIHIDPEYFRP 191
Cdd:pfam14125  84 FELLQSLLLGQLLE------PGRKELSVRLSKEGGVYLLTVKSGN---------------------FTYEFVIDPSNRRL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2528074342 192 YKLTLEDLEEDMGITAVYSDFKDINGKIFPEKMIFSSNFDENRIKVVLKLSRLEFDVNVTPTFRVPAKYKQL 263
Cdd:pfam14125 137 ESLEVVDSSGRRKLEVRYSNFQSVDEVLFPAEIEIQAYEGKKETTIVLEYSEVEFDEDLSFPFNVPSGYKRI 208
 
Name Accession Description Interval E-value
DUF4292 pfam14125
Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. ...
 33-263 4.35e-28

Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.


Pssm-ID: 464088  Cd Length: 208  Bit Score: 106.59  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342  33 YSKKVELSVDING-KENSLKGMLRIRRDSFIWMSVTAPLGIEVARIYLTPDSVKFLDSYNKKYLLTDYGFFYDRFGISIS 111
Cdd:pfam14125   4 LSGKAKVRLKTNGqKQVSLNVSIRMKKDEAIWLSAIPFLGIEVARALITPDSVLVYDRLNKRYFVGDYENLSKLLGIELS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342 112 FSCIQKILTNVYFNledcssSESRNDKFKFERTDNDYVLSNIQKRainrkikkffkkkrknkdfalVLQKIHIDPEYFRP 191
Cdd:pfam14125  84 FELLQSLLLGQLLE------PGRKELSVRLSKEGGVYLLTVKSGN---------------------FTYEFVIDPSNRRL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2528074342 192 YKLTLEDLEEDMGITAVYSDFKDINGKIFPEKMIFSSNFDENRIKVVLKLSRLEFDVNVTPTFRVPAKYKQL 263
Cdd:pfam14125 137 ESLEVVDSSGRRKLEVRYSNFQSVDEVLFPAEIEIQAYEGKKETTIVLEYSEVEFDEDLSFPFNVPSGYKRI 208
LolA_like cd16329
proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein ...
 180-254 2.74e-03

proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB; This family contains uncharacterized proteins similar to the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319986  Cd Length: 225  Bit Score: 38.07  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2528074342 180 QKIHIDPEYFRPYKLTLEDLEEDMGITAVYSDFKDINGKIFPEKMIFsSNFDENRiKVVLKLSRLEFDVNVTPTF 254
Cdd:cd16329   151 RVLWVDKDTFLPLKAEYYDRSGKLLKTLTFSDIKKIGGYWRPTRMEM-KDLLTGH-KTVLEYSDIKFNVGLPDSL 223
 
Name Accession Description Interval E-value
DUF4292 pfam14125
Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. ...
 33-263 4.35e-28

Domain of unknown function (DUF4292); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.


Pssm-ID: 464088  Cd Length: 208  Bit Score: 106.59  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342  33 YSKKVELSVDING-KENSLKGMLRIRRDSFIWMSVTAPLGIEVARIYLTPDSVKFLDSYNKKYLLTDYGFFYDRFGISIS 111
Cdd:pfam14125   4 LSGKAKVRLKTNGqKQVSLNVSIRMKKDEAIWLSAIPFLGIEVARALITPDSVLVYDRLNKRYFVGDYENLSKLLGIELS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2528074342 112 FSCIQKILTNVYFNledcssSESRNDKFKFERTDNDYVLSNIQKRainrkikkffkkkrknkdfalVLQKIHIDPEYFRP 191
Cdd:pfam14125  84 FELLQSLLLGQLLE------PGRKELSVRLSKEGGVYLLTVKSGN---------------------FTYEFVIDPSNRRL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2528074342 192 YKLTLEDLEEDMGITAVYSDFKDINGKIFPEKMIFSSNFDENRIKVVLKLSRLEFDVNVTPTFRVPAKYKQL 263
Cdd:pfam14125 137 ESLEVVDSSGRRKLEVRYSNFQSVDEVLFPAEIEIQAYEGKKETTIVLEYSEVEFDEDLSFPFNVPSGYKRI 208
LolA_like cd16329
proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein ...
 180-254 2.74e-03

proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB; This family contains uncharacterized proteins similar to the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319986  Cd Length: 225  Bit Score: 38.07  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2528074342 180 QKIHIDPEYFRPYKLTLEDLEEDMGITAVYSDFKDINGKIFPEKMIFsSNFDENRiKVVLKLSRLEFDVNVTPTF 254
Cdd:cd16329   151 RVLWVDKDTFLPLKAEYYDRSGKLLKTLTFSDIKKIGGYWRPTRMEM-KDLLTGH-KTVLEYSDIKFNVGLPDSL 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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