|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-484 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 684.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 HaKVTLAAGSTVTVTAaetsEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKK 160
Cdd:COG0469 81 G-PVELKKGDTFTLTT----DDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILKE 240
Cdd:COG0469 156 GVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETA 320
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 321 AGKYPLEAVKMMANIALIAEATMPEHNRLDIHTDETGIRaINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPM 400
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERT-ITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 401 LPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitfTDGVTSTNVVH 480
Cdd:COG0469 394 VPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVP------VGVPGTTNTLK 467
|
....
gi 2530024050 481 VAQV 484
Cdd:COG0469 468 VHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-463 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 612.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 hAKVTLAAGSTVTVTaaeTSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKK 160
Cdd:PRK05826 82 -GKITLKTGDKFTLD---TDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKE 240
Cdd:PRK05826 158 GINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEV-APEVcPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:PRK05826 238 SDGIMVARGDLGVEIpDEEV-PGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEaTMPEHNRLDIHTDETGIRaINSAIGLAAVSTAFNVK-ARAIIIPTESGRSARLVSNFR 398
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQFDR-IDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFR 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDP 463
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
2-481 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 593.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDH 81
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 AKVTLAAGSTVTVTAAETSEdlQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISG-QDIICHVDNGGELGEKK 160
Cdd:cd00288 81 KDISLKAGDKFLVTTDPAAK--KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILKE 240
Cdd:cd00288 159 GVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEV-APEVcPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:cd00288 238 SDGIMVARGDLGVEIpAEEV-FLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEATMPEHNRLD-IHTDETGIRAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFR 398
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNeMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPV-----TEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitftDGV 473
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWP-------VGS 469
|
....*...
gi 2530024050 474 TSTNVVHV 481
Cdd:cd00288 470 GSTNTMRI 477
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-481 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 3 KRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDhA 82
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG-G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 83 KVTLAAGSTVTVTAAETSEDlqGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKKGV 162
Cdd:TIGR01064 80 EVKLKKGDKVIITTDDIKGE--GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 163 NVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKESD 242
Cdd:TIGR01064 158 NLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 243 GIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAG 322
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 323 KYPLEAVKMMANIALIAEATMPEHNRLDIHTDETGI-RAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPML 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 402 PILAVTPHDAATRKMTIYWGVDPV-TEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitfTDGVTSTNVVH 480
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGP------IGGEGGTNTIR 471
|
.
gi 2530024050 481 V 481
Cdd:TIGR01064 472 V 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
2-349 |
6.30e-165 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 469.54 E-value: 6.30e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDH 81
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 AK-VTLAAGSTVTVTAAETSEDlQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISG-QDIICHVDNGGELGEK 159
Cdd:pfam00224 81 KKdIELKAGDEMIVSTDAKYKG-ACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDdKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 160 KGVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILK 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGK-NIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 240 ESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEATMPEHNRL 349
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-484 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 684.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 HaKVTLAAGSTVTVTAaetsEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKK 160
Cdd:COG0469 81 G-PVELKKGDTFTLTT----DDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILKE 240
Cdd:COG0469 156 GVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETA 320
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 321 AGKYPLEAVKMMANIALIAEATMPEHNRLDIHTDETGIRaINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPM 400
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERT-ITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 401 LPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitfTDGVTSTNVVH 480
Cdd:COG0469 394 VPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVP------VGVPGTTNTLK 467
|
....
gi 2530024050 481 VAQV 484
Cdd:COG0469 468 VHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-463 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 612.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 hAKVTLAAGSTVTVTaaeTSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKK 160
Cdd:PRK05826 82 -GKITLKTGDKFTLD---TDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKE 240
Cdd:PRK05826 158 GINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEV-APEVcPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:PRK05826 238 SDGIMVARGDLGVEIpDEEV-PGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEaTMPEHNRLDIHTDETGIRaINSAIGLAAVSTAFNVK-ARAIIIPTESGRSARLVSNFR 398
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQFDR-IDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFR 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDP 463
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
2-481 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 593.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDH 81
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 AKVTLAAGSTVTVTAAETSEdlQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISG-QDIICHVDNGGELGEKK 160
Cdd:cd00288 81 KDISLKAGDKFLVTTDPAAK--KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILKE 240
Cdd:cd00288 159 GVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEV-APEVcPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:cd00288 238 SDGIMVARGDLGVEIpAEEV-FLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEATMPEHNRLD-IHTDETGIRAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFR 398
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNeMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPV-----TEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitftDGV 473
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWP-------VGS 469
|
....*...
gi 2530024050 474 TSTNVVHV 481
Cdd:cd00288 470 GSTNTMRI 477
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-481 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 3 KRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDhA 82
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG-G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 83 KVTLAAGSTVTVTAAETSEDlqGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKKGV 162
Cdd:TIGR01064 80 EVKLKKGDKVIITTDDIKGE--GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 163 NVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKESD 242
Cdd:TIGR01064 158 NLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 243 GIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAG 322
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 323 KYPLEAVKMMANIALIAEATMPEHNRLDIHTDETGI-RAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPML 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 402 PILAVTPHDAATRKMTIYWGVDPV-TEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitfTDGVTSTNVVH 480
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGP------IGGEGGTNTIR 471
|
.
gi 2530024050 481 V 481
Cdd:TIGR01064 472 V 472
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-485 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 546.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:PRK06354 6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 HAkVTLAAGSTVTVTaaetSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSI--SGQDIICHVDNGGELGE 158
Cdd:PRK06354 86 GP-IELKTGDEFILT----SREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVLVGGVLSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 159 KKGVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEIL 238
Cdd:PRK06354 161 KKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 239 KESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGE 318
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 319 TAAGKYPLEAVKMMANIALIAEATMPEHNRLDIHTDETgiRAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFR 398
Cdd:PRK06354 321 TAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFT--TTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPdtsitftDGVT-STN 477
Cdd:PRK06354 399 PKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTL-------VGESgSTD 471
|
....*...
gi 2530024050 478 VVHVAQVR 485
Cdd:PRK06354 472 LMKVHVVG 479
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
3-481 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 514.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 3 KRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDHA 82
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 83 KVTLAAGSTVTVTaaeTSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKKGV 162
Cdd:PRK09206 82 DVSLKAGQTFTFT---TDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 163 NVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKESD 242
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 243 GIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAG 322
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 323 KYPLEAVKMMANIALIAEATMPehNRLDIHTDETGIRaINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPMLP 402
Cdd:PRK09206 319 KYPLEAVSIMATICERTDRVMN--SRLESNNDNRKLR-ITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDAT 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2530024050 403 ILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGdpdtsITFTDGVTSTNVVHV 481
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSG-----ALVPSGTTNTASVHV 469
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
2-349 |
6.30e-165 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 469.54 E-value: 6.30e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDH 81
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 AK-VTLAAGSTVTVTAAETSEDlQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISG-QDIICHVDNGGELGEK 159
Cdd:pfam00224 81 KKdIELKAGDEMIVSTDAKYKG-ACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDdKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 160 KGVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILK 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGK-NIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 240 ESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGET 319
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 2530024050 320 AAGKYPLEAVKMMANIALIAEATMPEHNRL 349
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-484 |
5.30e-159 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 459.39 E-value: 5.30e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 1 MNKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKD 80
Cdd:PRK06247 3 RNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 81 HaKVTLAAGSTVTVTaaetSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKK 160
Cdd:PRK06247 83 G-KVQLANGQTFRLD----VDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 161 GVNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCqengGGNIDIFPKIECAVAVYHFDEILKE 240
Cdd:PRK06247 158 GVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII----GGRVPVMAKIEKPQAIDRLEAIVEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 241 SDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETA 320
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 321 AGKYPLEAVKMMANIALIAEATmPEHNRLdIHTDETGIRAINS-AIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRP 399
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERD-PTYPPL-IHAQRPQPEATKRdAISYAARDIAERLDLAALVAYTSSGDTALRAARERP 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 400 MLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGDPDTsitfTDGvtSTNVV 479
Cdd:PRK06247 392 PLPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPG----TPG--STNML 465
|
....*
gi 2530024050 480 HVAQV 484
Cdd:PRK06247 466 RIAYI 470
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-461 |
3.20e-151 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 441.12 E-value: 3.20e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRElgIP---VGILLDTKGPEIRTGFL 78
Cdd:PTZ00066 37 QKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKA--RPnanLGILLDTKGPEIRTGFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 79 KDHAKVTLAAGSTVTVTaaeTSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGE 158
Cdd:PTZ00066 115 KNHKPITLKEGQTLKIT---TDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 159 KKGVNVPNAKLSLPTITEQDRKDIL-FGIEEGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEI 237
Cdd:PTZ00066 192 RKNMNLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR-HIKIIPKIENIEGLINFDEI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 238 LKESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSG 317
Cdd:PTZ00066 271 LAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSG 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 318 ETAAGKYPLEAVKMMANIALIAEATM--PEHNRLDIHTDETGIrAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVS 395
Cdd:PTZ00066 351 ETANGKFPVEAVNIMAKICFEAETCIdyRVLYHAIHLAVPTPV-SVQEAVARSAVETAEDINAKLIIALTETGNTARLIS 429
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2530024050 396 NFRPMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVG 461
Cdd:PTZ00066 430 KYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHG 495
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-461 |
7.31e-147 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 429.78 E-value: 7.31e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDH 81
Cdd:PLN02461 20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 AKVTLAAGSTVTVTaaeTSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKS--ISGQDIICHVDNGGELGEK 159
Cdd:PLN02461 100 KPVQLKQGQEITIT---TDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGER 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 160 KGVNVPNAKLSLPTITEQDRKDIL-FGIEEGIDFIAASFIRDAAGVREIRKLCQEnGGGNIDIFPKIECAVAVYHFDEIL 238
Cdd:PLN02461 177 KNVNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGE-HAKSILLISKVENQEGLDNFDDIL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 239 KESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGE 318
Cdd:PLN02461 256 AESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 319 TAAGKYPLEAVKMMANIALIAEATMpEHNRLDIHTDETGIRAINSAIGLA--AVSTAFNVKARAIIIPTESGRSARLVSN 396
Cdd:PLN02461 336 TAAGAYPELAVKTMARICREAEASL-DYGALFKEIMRSAPLPMSPLESLAssAVRTANKVKASLIVVLTRGGTTARLVAK 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 397 FRPMLPILAV-------------TPHDAATRKMTIYWGVDPV-TEGEIGDK-----RYIVRTALECAKKRGVVRVGD--V 455
Cdd:PLN02461 415 YRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVlAEGSAKATdsestEEILEAAIEHAKKKGLCKPGDsvV 494
|
....*.
gi 2530024050 456 AVLTVG 461
Cdd:PLN02461 495 ALHRIG 500
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
29-462 |
7.61e-131 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 386.71 E-value: 7.61e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 29 MNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDHAKVtLAAGSTVTVTAAETSEDlQGTAE 108
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAV-MERGATCYVTTDPAFAD-KGTKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 109 HFYLDHLELPREVHPGGTILVDDGLIGLTVKSISG-QDIICHVDNGGELGEKKGVNVPNAKLSLPTITEQDRKDILFGIE 187
Cdd:PTZ00300 79 KFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDeQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 188 EGIDFIAASFIRDAAGVREIRKLCQENGGgNIDIFPKIECAVAVYHFDEILKESDGIMVARGDLGVEVAPEVCPTIQKEI 267
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGG-DIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 268 IQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAGKYPLEAVKMMANIALIAEATMPEHN 347
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 348 RLD-IHTDETGIRAINSAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPMLPILAVTPHDAATRKMTIYWGVDPV- 425
Cdd:PTZ00300 318 FFNsIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVf 397
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 2530024050 426 ----TEGEIGDKRYIVRTALECAKKRGVVRVGDVAVLTVGD 462
Cdd:PTZ00300 398 fdaeRLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHAD 438
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
3-461 |
1.33e-101 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 316.10 E-value: 1.33e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 3 KRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPV-GILLDTKGPEIRTGFLKDh 81
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 82 aKVTLAAGSTVTVTAAETSedlqGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKKG 161
Cdd:PLN02623 189 -PIMLEEGQEFTFTIKRGV----STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRH 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 162 VNVPNAKLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQeNGGGNIDIFPKIECAVAVYHFDEILKES 241
Cdd:PLN02623 264 LNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLK-SCNADIHVIVKIESADSIPNLHSIITAS 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 242 DGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAA 321
Cdd:PLN02623 343 DGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 322 GKYPLEAVKMMANIALIAEATMPEHNrldihTDETGIRAINSAIG--LAAVSTAF-NVKARAIIIPTESGRSARLVSNFR 398
Cdd:PLN02623 423 GKFPLKAVKVMHTVALRTEATLPEGT-----TPPNLGQAFKNHMSemFAFHATMMaNTLGTSIIVFTRTGFMAILLSHYR 497
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2530024050 399 PMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGD-VAVLTVG 461
Cdd:PLN02623 498 PSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEeVALVQSG 561
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
5-462 |
5.58e-99 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 307.37 E-value: 5.58e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 5 TKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTgFLKDHAKV 84
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQV-INKTEKPI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 85 TLAAGSTVTVTAAETSEdlqGTAEHFYLDHLELPREVHPGGTILVDDGL--------IGLTVKSISGQDIICHVDNGGEL 156
Cdd:PLN02765 109 SLKAGNTVTLTPDQSKE---ASSEVLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKGDDVVCTVKNSATL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 157 -GEKKGVNVPNAKLSLPTITEQDRKDI-LFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHF 234
Cdd:PLN02765 186 aGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTHF 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 235 DEILKESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITaTQMLDSMIRNPRPTRAEVTDVANAINDGTDATM 314
Cdd:PLN02765 266 DEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAIL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 315 LSGETAAGKYPLEAVKMMANIALIAEATMPEHN---RLDIHTDE--TGIRAINSaiglAAVSTAFNVKARAIIIPTESGR 389
Cdd:PLN02765 345 LGAETLRGLYPVETISTVGRICAEAEKVFNQDLyfkKTVKYVGEpmSHLESIAS----SAVRAAIKVKASVIIVFTSSGR 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 390 SARLVSNFRPMLPILAVTPHDAAT-------------RKMTIYWGVDPV-------TEGEIGDKRYIVRTALECAKKRGV 449
Cdd:PLN02765 421 AARLIAKYRPTMPVLSVVIPRLKTnqlkwsftgafqaRQCLIVRGLFPMladprhsAESTSATNESVLKVALDHGKAAGV 500
|
490
....*....|....*
gi 2530024050 450 VRVGDVAVL--TVGD 462
Cdd:PLN02765 501 IKSHDRVVVcqKVGD 515
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
3-469 |
1.25e-97 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 303.59 E-value: 1.25e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 3 KRTKIVCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTGFLKDHA 82
Cdd:PLN02762 25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 83 KVTLAAGS--TVTVTAAETSE---DLQGTAEHFYLDhlelpreVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELg 157
Cdd:PLN02762 105 SAKAEDGEewTFTVRKFDGSRpefTIQVNYDGFAED-------VKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLL- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 158 ekkgvnVPNAKLS--------------LPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENG-GGNIDIF 222
Cdd:PLN02762 177 ------LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 223 PKIECAVAVYHFDEILKESDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDV 302
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 303 ANAINDGTDATMLSGETAAGKYPLEAVKMMANIALIAEATMPEHNRLD-IHTDETGIR---AINSAIGLAAVSTAFNVKA 378
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEaLELPQLSSSlsdRISEEICNSAAKMANNLGV 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 379 RAIIIPTESGRSARLVSNFRPMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALECAKKRGVVRVGDVaVL 458
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDL-VI 489
|
490
....*....|.
gi 2530024050 459 TVGDPDTSITF 469
Cdd:PLN02762 490 AVSDLTPSSML 500
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
8-340 |
5.43e-97 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 296.47 E-value: 5.43e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 8 VCTMGPACDDDDILREMIKSGMNVARFNFSHGSHEEQhirmERVKRISRELGIPVGILLDTKGPEIRTGFLKDHaKVTLA 87
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESH----KDIIRLVKSLDDSIKILGDVQGPKIRLGEIKGE-QITLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 88 AGSTVTVTaaetSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEKKGVNVPNA 167
Cdd:PRK06739 81 AGDSFILH----TQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 168 KLSLPTITEQDRKDILFGIEEGIDFIAASFIRDAAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKESDGIMVA 247
Cdd:PRK06739 157 IVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 248 RGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAGKYPLE 327
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316
|
330
....*....|...
gi 2530024050 328 AVKMMANIALIAE 340
Cdd:PRK06739 317 SVSTLRLVSEFAE 329
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
270-482 |
1.72e-54 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 185.10 E-value: 1.72e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 270 KCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAINDGTDATMLSGETAAGKYPLEAVKMMANIALIAEATMPEHNRL 349
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 350 DIHTDETGIRAINsAIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPMLPILAVTPHDAATRKMTIYWGVDPVTEGE 429
Cdd:COG3848 81 VPRAKESSTTITD-AISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEE 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2530024050 430 IGDKRYIVRTALECAKKRGVVRVGDVAVLTVGdpdtsiTFTDGVTSTNV--VHVA 482
Cdd:COG3848 160 SASTDEMFAVAVALALEAGLVKDGDLVVITAG------VPVGVSGTTNLlkVHVV 208
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-346 |
4.48e-47 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 169.81 E-value: 4.48e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTM-GPACDDDDILREMIKSGMNVARFNFSHGSHEEQHIRMERVKRISRELGIPVGILLDTKGPEIRTG-FLK 79
Cdd:PRK08187 132 ARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGaVAG 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 80 DHAKVTLAAGSTVTVTAAETSEDLQGTAEHFYLDHLELPREVHPGGTILVDDGLIGLTVKSISGQDIICHVDNGGELGEK 159
Cdd:PRK08187 212 PLGKTRLYTGDRLALVAQGPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPKGLK 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 160 ----KGVNVPNAKLSLPTITEQDRKDILFGIEEGiDFIAASFIRDAAGVREIRKLCQENGGGNID---IFPKIECAVAVY 232
Cdd:PRK08187 292 lkpeKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDDWRklgLVLKIETPRAVA 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 233 HFDEILKESDG-----IMVARGDLGVEVAPEVCPTIQKEIIQKCNKAYKPVITATQMLDSMIRNPRPTRAEVTDVANAin 307
Cdd:PRK08187 371 NLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA-- 448
|
330 340 350
....*....|....*....|....*....|....*....
gi 2530024050 308 DGTDATMLSgetaAGKYPLEAVKMMANIAliaeATMPEH 346
Cdd:PRK08187 449 ARAECVMLN----KGPYLVEAVTFLDDLL----ARMDGH 479
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
2-335 |
3.90e-40 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 152.80 E-value: 3.90e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 2 NKRTKIVCTM-GPACDDDDILREMIKSGMNVARFNFSHGShEEQHIRM-ERVKRISRELGIPVGILLDTKGPEIRTGFLK 79
Cdd:PRK14725 138 GRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDD-PEAWRAMiANVRTAEEELGRRCRIAMDLAGPKLRTGPIA 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 80 DH-------------------AKVTLAAGSTVTVTAAETSEDLQGTAEHF------------------------------ 110
Cdd:PRK14725 217 PGprviklrptrdalgrvltpARLWLTASESPPPSPPPGPVGLPVDPEWLarlepgdelrftdargkkrkltvtevddeg 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 111 ---------YL-------------------------------DHLELPRE--------------------------VHPG 124
Cdd:PRK14725 297 vlaegsqtaYLangtllrlgrhdstrvgglppveqklrlkvgDRLVLTRDdapgdpaqgdapparisctlpeafraARVG 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 125 GTILVDDGLIGLTVKSISGQDIICHVDNGGELGEK----KGVNVPNAKLSLPTITEQDRKDILFgIEEGIDFIAASFIRD 200
Cdd:PRK14725 377 ERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRS 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 201 AAGVREIRKLCQENGGGNIDIFPKIECAVAVYHFDEILKE-----SDGIMVARGDLGVEVAPEVCPTIQKEIIQKCNKAY 275
Cdd:PRK14725 456 PEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILLEamrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAH 535
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 276 KPVITATQMLDSMIRNPRPTRAEVTDVANAINdgTDATMLSgetaAGKYPLEAVKMMANI 335
Cdd:PRK14725 536 VPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDI 589
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
364-481 |
1.97e-30 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 114.11 E-value: 1.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530024050 364 AIGLAAVSTAFNVKARAIIIPTESGRSARLVSNFRPMLPILAVTPHDAATRKMTIYWGVDPVTEGEIGDKRYIVRTALEC 443
Cdd:pfam02887 2 AIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKV 81
|
90 100 110
....*....|....*....|....*....|....*...
gi 2530024050 444 AKKRGVVRVGDVAVLTVGDPdtsitfTDGVTSTNVVHV 481
Cdd:pfam02887 82 AKEAGLVKKGDLVVITAGVP------FGVSGTTNTLKV 113
|
|
| |
