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Conserved domains on  [gi|2532338615|ref|WP_289859991|]
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iron ABC transporter permease [uncultured Muribaculum sp.]

Protein Classification

iron ABC transporter permease( domain architecture ID 10470548)

iron ABC transporter permease is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and/or iron-containing compounds

Gene Ontology:  GO:0140359|GO:0042626|GO:0006826
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BtuC super family cl42616
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 43-333 1.05e-84

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


The actual alignment was detected with superfamily member COG4139:

Pssm-ID: 443314  Cd Length: 327  Bit Score: 258.63  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  43 AARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGtisaggysVGGYVAVM 122
Cdd:COG4139    46 AWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGG--------LLPPWLLS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 123 AAAFAGSMLIMGLLLLFSSWLKNDLMLLITGIMVGYMTSSVISLLNYMSSADGVQSYVMWGMGNFNGVSLSRLPLFALIT 202
Cdd:COG4139   118 LAAIAGALLVTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 203 LAgIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDnHRVLM 282
Cdd:COG4139   198 PV-LLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTD-HRFLL 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2532338615 283 PATLISGAIVALGCNLVCVLP-ESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:COG4139   276 PACALAGAALLLLADIIARLAlSSAELPIGVVTATLGAPVFIWLLLRRRKIR 327
 
Name Accession Description Interval E-value
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 43-333 1.05e-84

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 258.63  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  43 AARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGtisaggysVGGYVAVM 122
Cdd:COG4139    46 AWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGG--------LLPPWLLS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 123 AAAFAGSMLIMGLLLLFSSWLKNDLMLLITGIMVGYMTSSVISLLNYMSSADGVQSYVMWGMGNFNGVSLSRLPLFALIT 202
Cdd:COG4139   118 LAAIAGALLVTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 203 LAgIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDnHRVLM 282
Cdd:COG4139   198 PV-LLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTD-HRFLL 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2532338615 283 PATLISGAIVALGCNLVCVLP-ESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:COG4139   276 PACALAGAALLLLADIIARLAlSSAELPIGVVTATLGAPVFIWLLLRRRKIR 327
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-328 2.53e-58

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 190.43  E-value: 2.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  17 NLYFGSVAISAADVTDILLGHDGDygAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLG 96
Cdd:pfam01032   9 SLFIGAVKISPSDVFSALLGGDDS--LAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  97 VAIVMLFLGGTisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSSWLK--NDLMLLITGIMVGYMTSSVISLLNYMSSAD 174
Cdd:pfam01032  87 AVLAILLGGSL---------SLFALPLAAFIGALLAALLVYFLSRGRGgaSPLRLILAGIAVSALLSALTSLLLLLLNPE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 175 GVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAY 254
Cdd:pfam01032 158 ALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAV 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532338615 255 CGPISFIGLAVPHIARLLFRTdNHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILR 328
Cdd:pfam01032 238 VGPIGFVGLIVPHIARLLVGA-NHRRLLPLSALLGALLLLLADILArTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 52-333 2.24e-43

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 152.03  E-value: 2.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  52 RLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTISaggysvggYVAVMAAAFAGSML 131
Cdd:PRK03784   58 RLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLP--------PWALSLCAIAGALL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 132 IMGLLLLFSSWLK-NDLMLLITGIMVGYMTSSVISLLNYMSSADGVQSYVMWGMGNFNGVSLsRLPLFALITLAGIVMAL 210
Cdd:PRK03784  130 ITLILLRFARRHRlSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDW-RQSWLMLALLPVLIWLC 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 211 LLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDnHRVLMPATLISGA 290
Cdd:PRK03784  209 CQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTD-HRVLLPGCALAGA 287

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2532338615 291 IVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:PRK03784  288 SLLLLADIVArLALASAELPIGVVTATLGAPVFIWLLLRSHRAR 331
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 57-326 2.61e-34

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 126.13  E-value: 2.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  57 VTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTISAggysvggyvAVMAAAFAGSMLI-MGL 135
Cdd:cd06550     2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY---------ALGAFAFAGALAIaLLV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 136 LLLFSSWLKNDLMLLITGIMVGYMTSSVISLLNYMSSaDGVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKP 215
Cdd:cd06550    73 LLLASRGGLSPSKLILIGIVLSAFFSAGVILISLLSD-DSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 216 LNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFrTDNHRVLMPATLISGAIVALG 295
Cdd:cd06550   152 LNLLTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLF-GRSHRYLLPLSALLGAILLLL 230

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2532338615 296 CNLVCVLPESTILPINAVTPLVGAPVILYVI 326
Cdd:cd06550   231 GDLLSRTLLPSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 43-333 1.05e-84

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 258.63  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  43 AARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGtisaggysVGGYVAVM 122
Cdd:COG4139    46 AWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGG--------LLPPWLLS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 123 AAAFAGSMLIMGLLLLFSSWLKNDLMLLITGIMVGYMTSSVISLLNYMSSADGVQSYVMWGMGNFNGVSLSRLPLFALIT 202
Cdd:COG4139   118 LAAIAGALLVTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 203 LAgIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDnHRVLM 282
Cdd:COG4139   198 PV-LLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTD-HRFLL 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2532338615 283 PATLISGAIVALGCNLVCVLP-ESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:COG4139   276 PACALAGAALLLLADIIARLAlSSAELPIGVVTATLGAPVFIWLLLRRRKIR 327
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 18-330 1.38e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 244.98  E-value: 1.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  18 LYFGSVAISAADVTDILLGHDGDyGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGV 97
Cdd:COG0609     2 LSLGAVPISLSDVLRALLGPDGD-PTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  98 AIVMLFLGGTisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSSWLKND--LMLLITGIMVGYMTSSVISLLNYMSSADG 175
Cdd:COG0609    81 VLAIVLGGGL---------SALGLPLAAFLGALLAALLVYLLARRGGGLspLRLVLAGVAVSALFSALTSLLLLLADPEQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 176 VQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYC 255
Cdd:COG0609   152 LRSIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVA 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532338615 256 GPISFIGLAVPHIARLLFRTDnHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRER 330
Cdd:COG0609   232 GPIGFVGLVVPHIARLLVGPD-HRRLLPASALLGALLLLLADTLArTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-328 2.53e-58

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 190.43  E-value: 2.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  17 NLYFGSVAISAADVTDILLGHDGDygAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLG 96
Cdd:pfam01032   9 SLFIGAVKISPSDVFSALLGGDDS--LAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  97 VAIVMLFLGGTisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSSWLK--NDLMLLITGIMVGYMTSSVISLLNYMSSAD 174
Cdd:pfam01032  87 AVLAILLGGSL---------SLFALPLAAFIGALLAALLVYFLSRGRGgaSPLRLILAGIAVSALLSALTSLLLLLLNPE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 175 GVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAY 254
Cdd:pfam01032 158 ALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAV 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2532338615 255 CGPISFIGLAVPHIARLLFRTdNHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILR 328
Cdd:pfam01032 238 VGPIGFVGLIVPHIARLLVGA-NHRRLLPLSALLGALLLLLADILArTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 18-333 8.16e-50

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 169.15  E-value: 8.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  18 LYFGSVAISAADVTDILLGHDGdyGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGV 97
Cdd:COG4779    41 LTLGDYPLSPGDVLRALLGEGD--PGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  98 AIVMLFLGGtisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSsWLK--NDLMLLITGIMVGYMTSSVISLLNYMSSADG 175
Cdd:COG4779   119 VAAIVVLGG----------SGLAVALGALAGGLATALLVYLLA-WRGgvSGYRLILVGIGVSAMLTAVNSYLLTRADLED 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 176 VQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYC 255
Cdd:COG4779   188 AQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAA 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2532338615 256 GPISFIGLAVPHIARLLFRTdnHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:COG4779   268 GPIAFVALAAPQIARRLTRS--PGPPLLPSALVGALLLLAADLVAqHLLAPVQLPVGVVTGALGGPYLLWLLIRENRRG 344
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 52-333 2.24e-43

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 152.03  E-value: 2.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  52 RLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTISaggysvggYVAVMAAAFAGSML 131
Cdd:PRK03784   58 RLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLP--------PWALSLCAIAGALL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 132 IMGLLLLFSSWLK-NDLMLLITGIMVGYMTSSVISLLNYMSSADGVQSYVMWGMGNFNGVSLsRLPLFALITLAGIVMAL 210
Cdd:PRK03784  130 ITLILLRFARRHRlSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDW-RQSWLMLALLPVLIWLC 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 211 LLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDnHRVLMPATLISGA 290
Cdd:PRK03784  209 CQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTD-HRVLLPGCALAGA 287

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2532338615 291 IVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:PRK03784  288 SLLLLADIVArLALASAELPIGVVTATLGAPVFIWLLLRSHRAR 331
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
21-334 1.05e-36

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 139.59  E-value: 1.05e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  21 GSVAISAADVTDILLGHDGDyGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIV 100
Cdd:PRK10577   32 LSAALPLSQWLQALWGPDAD-DLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 101 MLFLGGTISAGGysvggyvavMAAAFAGSMLIMGLLLLFsSWLKN--DLMLLITGIMVGYMTSSVISLLNYMsSADGVQS 178
Cdd:PRK10577  111 TLFAPALLALAS---------QLAAFAGGLLAAALVFAL-AGGKRlsPLRLVLAGMVVSLYLGALTTLLLLF-NEQYLQG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 179 YVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPI 258
Cdd:PRK10577  180 LFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPI 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 259 SFIGLAVPHIARLL-FRTdnHRVLMPATLISGAIVALGCNLVCVL---PESTILPINAVTPLVGAPVILYVILRERRGRH 334
Cdd:PRK10577  260 GFIGLAAPNLARLLgARR--LRARLPLSPLIGALLLLLTDQLVRLlagVGGELLPTGAVTALIGAPLLLWLLPRLRSAQS 337
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 57-326 2.61e-34

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 126.13  E-value: 2.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  57 VTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTISAggysvggyvAVMAAAFAGSMLI-MGL 135
Cdd:cd06550     2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY---------ALGAFAFAGALAIaLLV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 136 LLLFSSWLKNDLMLLITGIMVGYMTSSVISLLNYMSSaDGVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKP 215
Cdd:cd06550    73 LLLASRGGLSPSKLILIGIVLSAFFSAGVILISLLSD-DSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 216 LNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFrTDNHRVLMPATLISGAIVALG 295
Cdd:cd06550   152 LNLLTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLF-GRSHRYLLPLSALLGAILLLL 230

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2532338615 296 CNLVCVLPESTILPINAVTPLVGAPVILYVI 326
Cdd:cd06550   231 GDLLSRTLLPSELPVGPVTALLGAPYFLYLL 261
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
52-331 4.35e-33

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 129.19  E-value: 4.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  52 RLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTisaggysvgGYVAVMAAAFAGSML 131
Cdd:PRK10577  397 RLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGA---------GFGWLLAAALLGALA 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 132 IMGLLLLFSSWLK-NDLMLLITGIMVGYMTSSVISLLnyMSSAD-GVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMA 209
Cdd:PRK10577  468 ALALILLLARRGGfAPERLLLTGIALSALFTALIQLL--LASGDpRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALA 545

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 210 LLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLL-FRTdnHRVLMPATLIS 288
Cdd:PRK10577  546 LLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLgGRR--ARPQLVLAALL 623

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2532338615 289 GAIVALGCNLV--CVLPESTIlPINAVTPLVGAPVILYVILRERR 331
Cdd:PRK10577  624 GALLMVLADWLgrTLLFPYQI-PAGLLAALIGAPYFLWLLRRSRR 667
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
16-333 1.47e-30

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 118.27  E-value: 1.47e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  16 MNLYFGSVAISAADVTDILLGHDgdYGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASL 95
Cdd:PRK10441   26 LSLLIGAKSLPASVVLEALSGTC--QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASF 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  96 GVAIVMLFLGGTisaggySVGGYvavMAAAFAGSmLIMGLLLLFSSWLK----NDLMLLITGIMVGYM---TSSVISLLN 168
Cdd:PRK10441  104 AIVLGAALFGYS------SAQEQ---LAMAFAGA-LVASLIVAFTGSQGggqlSPVRLTLAGVALAAVlegLTSGIALLN 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 169 ymssADGVQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLT 248
Cdd:PRK10441  174 ----PDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLC 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 249 AVITAYCGPISFIGLAVPHIARLLFRTDnHRVLMPATLISGAIVALGCNLVCVLPESTILPINAVTPLVGAPVILYVILR 328
Cdd:PRK10441  250 GSATAVVGPIAFIGLMMPHMARWLVGAD-HRWSLPVTLLATPALLLFADIIGRLLVPGELRVSVVSAFIGAPVLIFLVRR 328


                  ....*
gi 2532338615 329 ERRGR 333
Cdd:PRK10441  329 KTRGG 333
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
16-330 1.62e-29

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 115.14  E-value: 1.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  16 MNLYFGSVAISAADVTDILLGHDGDYgaarFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASL 95
Cdd:PRK09777   19 LSLRMGVIPLPWRALLTDWQAGDEHY----YVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  96 GVAIVMLFLGGTisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSSwLKNDLMLLITGIMVGYMTSSVISLLnYMSSADG 175
Cdd:PRK09777   95 ASVGALLLFPSL---------PVMWLPLLAFIGGMAGLILLKMLAG-THQPMKLALTGVALSALWASLTDYL-MLSRPQD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 176 VQSYVMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYC 255
Cdd:PRK09777  164 INNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAAC 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2532338615 256 GPISFIGLAVPHIARLLFrTDNHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRER 330
Cdd:PRK09777  244 GPISFIGLVVPHLMRSLV-GGRHRRLLPVSALTGALLLLLADLLArIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
21-333 1.68e-28

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 112.50  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  21 GSVAISAADVTDILLGHDGdyGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIV 100
Cdd:PRK10440   30 GAVTLETSQVFAALMGDAP--RSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 101 MLFLGGtisaggysvgGYVAVMAAAFAGSMLIMGLLLLFSsWLK--NDLMLLITGIMVGYMTSSVISLLNYMSSADGVQS 178
Cdd:PRK10440  108 MVLFGQ----------DLTAIALAAMAGGIVTSLLVWLLA-WRNgiDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALT 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 179 YVMWGMGNFNGVSLSR-LPLFALITLAgIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGP 257
Cdd:PRK10440  177 AGLWNAGSLNGLTWAKtSPSAPIIILM-LIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGP 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2532338615 258 ISFIGLAVPHIARLLFRTDnhRVLMPATLISGAIVALGCNLVCV-LPESTILPINAVTPLVGAPVILYVILRERRGR 333
Cdd:PRK10440  256 ISFIALVAPHIARRLSGTA--RWGLTQAALCGALLLLAADLCAQqLFMPYQLPVGVVTVSLGGIYLIVLLIQESRKK 330
btuC PRK09535
cobalamin ABC transporter permease BtuC;
42-330 1.96e-28

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 112.92  E-value: 1.96e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  42 GAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGvAIVMLFLGGTISAGgysvggyvaV 121
Cdd:PRK09535   85 ETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVG-AVAAIVLPLAVPFG---------L 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 122 MAAAFAGSMLIMGLLLLFSSwlKND----LMLLITGIMVGYMTSSVISLLnYMSSADGVQSYVMWGMGNFNGVSLSRLPL 197
Cdd:PRK09535  155 QAAAFAGALVAAFGVYAIAT--ENGrtpvATLLLAGVAVQTFLGAVISYL-LLHSGESLRRAVYWLMGHLHGSTWSDVEV 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 198 FALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDn 277
Cdd:PRK09535  232 ALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPD- 310

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2532338615 278 HRVLMPATLISGAIVALGCNLVCVLpESTILPINAVTPLVGAPVILYvILRER 330
Cdd:PRK09535  311 HRILLPTSALAGASFLVATDTVARS-GPAEVPVGIVTAALGAPFFLY-LLRTR 361
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
22-330 6.20e-27

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 108.24  E-value: 6.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  22 SVAISAADVTDILLGHDGDyGAARFIVTGSRLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVM 101
Cdd:PRK11228   22 AIPISAADALNALLPGHTP-TLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 102 LFLGGTISaggysvgGYVAVMAAAFAGSMLIMGLLLLFSSWLKNDLM--LLITGIMVGYMTSSVISLLNYMSSaDGVQSY 179
Cdd:PRK11228  101 ALSPTPFA-------GYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRnrLILAGIALSALCMALTRITLLLAE-DHAYGI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 180 VMWGMGNFNGVSLSRLPLFALITLAGIVMALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPIS 259
Cdd:PRK11228  173 FYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVA 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2532338615 260 FIGLAVPHIARLLFRTDnHRVLMPATLISGAIVALGCNLVC-VLPESTILPINAVTPLVGAPVILYVILRER 330
Cdd:PRK11228  253 FIGLLVPHLARFWIGYD-QRNVLPMSMLLGATLMLLADLLArALAFPGELPAGAVLALIGAPCFVWLARRRG 323
CeuC COG4605
ABC-type enterochelin transport system, permease component [Inorganic ion transport and ...
 52-331 1.28e-21

ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443655  Cd Length: 317  Bit Score: 93.25  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615  52 RLPQAVTALLAGAGLAVSGLMLQTAFRNPLAGPSILGINSGASLGVAIVMLFLGGTISAGGYSVGGYVAVMAAAFAGSML 131
Cdd:COG4605    39 RGTKLAAMLLVAIAIAVSTVLFQTITNNRILTPSIMGFDSLYVLIQTLLVFFLGSAGLAALNPLLNFLLEVALMVGFSLL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 132 IMGLLllFSSWLKNDLMLLITGIMVGYMTSSVISLLNYM---SSADGVQSYVMwgmGNFNGVSLSRLPLFALITLAGIVM 208
Cdd:COG4605   119 LYRWL--FRGGRRNLHLLLLVGVVLGTLFRSLSSFLQRLidpNEFDVLQDRLF---ASFNNVNTDLLLIAAVIVLLALLL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532338615 209 ALLLIKPLNIILLGSNYARNLGISMRRVRNLLLLATGLLTAVITAYCGPISFIGLAVPHIARLLFRTDNHRVLMPATLIS 288
Cdd:COG4605   194 LWRLRRRLDVLALGRDQAINLGVDYRRVVRRLLILVAVLVAVSTALVGPITFLGLLVANLAYQLFGTYRHRYLLPAAALI 273

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2532338615 289 GAIVALGCNLVC--VLPESTILPInaVTPLVGAPVILYVILRERR 331
Cdd:COG4605   274 GVIALVGGQFVVehVFNFSTTLSV--IIEFVGGIYFLYLLLRKRR 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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