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Conserved domains on  [gi|2532799794|ref|WP_290218844|]
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polymorphic toxin type 46 domain-containing protein [Pseudoalteromonas sp. APC 3218]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ntox46 super family cl21342
Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The ...
 122-258 1.47e-45

Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system.


The actual alignment was detected with superfamily member pfam15538:

Pssm-ID: 406080  Cd Length: 157  Bit Score: 150.15  E-value: 1.47e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794 122 IKQRKLVAFEFYKSQGFKEEDIPSHLTGIDFAHPVEKVMIESGQVFYQFQSPGAPQGNYYSDDPNITPTQLGISPMGTNR 201
Cdd:pfam15538  21 IRGNQETAAKFFKSKDIDPADAEGYMNGLDFNHPVFTETIAPGKNLWQFQSPGAPQGMWYSLSPDVQPGELGINPLGQIF 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2532799794 202 ALNSIEPKIKGVYIAQEDTPALRSRAKAVDDFWSVRGESYPTEGGGTQYFTANKLAF 258
Cdd:pfam15538 101 AAETIEPKILNSYQSTEKVELLRSTAAPTDDFWSVKGQPYNAIGGAQQLFSAEKELF 157
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 29-106 4.32e-34

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


:

Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 117.99  E-value: 4.32e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2532799794  29 DVYGYEESEantTNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQDPIGLVGGINHYQYAP-NPVNWVDPFGL 106
Cdd:TIGR03696   2 DPYGEVLSE---SGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYVGnNPVNWVDPLGL 77
RHS super family cl04135
RHS protein;
2-32 4.28e-05

RHS protein;


The actual alignment was detected with superfamily member pfam03527:

Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 39.98  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2532799794   2 YYYHLDQLNTPRFVTNNKTEVVWENQADVYG 32
Cdd:pfam03527   2 YYYHTDHLGTPEELTDEAGEIVWSAEYDAWG 32
 
Name Accession Description Interval E-value
Ntox46 pfam15538
Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The ...
 122-258 1.47e-45

Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system.


Pssm-ID: 406080  Cd Length: 157  Bit Score: 150.15  E-value: 1.47e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794 122 IKQRKLVAFEFYKSQGFKEEDIPSHLTGIDFAHPVEKVMIESGQVFYQFQSPGAPQGNYYSDDPNITPTQLGISPMGTNR 201
Cdd:pfam15538  21 IRGNQETAAKFFKSKDIDPADAEGYMNGLDFNHPVFTETIAPGKNLWQFQSPGAPQGMWYSLSPDVQPGELGINPLGQIF 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2532799794 202 ALNSIEPKIKGVYIAQEDTPALRSRAKAVDDFWSVRGESYPTEGGGTQYFTANKLAF 258
Cdd:pfam15538 101 AAETIEPKILNSYQSTEKVELLRSTAAPTDDFWSVKGQPYNAIGGAQQLFSAEKELF 157
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 29-106 4.32e-34

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 117.99  E-value: 4.32e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2532799794  29 DVYGYEESEantTNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQDPIGLVGGINHYQYAP-NPVNWVDPFGL 106
Cdd:TIGR03696   2 DPYGEVLSE---SGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYVGnNPVNWVDPLGL 77
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 5-108 6.38e-33

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 126.79  E-value: 6.38e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794    5 HLDQLNTPRFVTNNKTEVVWENQADVYGyeESEANTTNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQDPIGL 84
Cdd:COG3209    925 HTDHLGSVRALTDASGQVVWRYDYDPFG--NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGL 1002

                           90       100
                   ....*....|....*....|....*
gi 2532799794   85 VGGINHYQYA-PNPVNWVDPFGLSC 108
Cdd:COG3209   1003 AGGLNLYAYVgNNPVNYVDPLGLAA 1027
RHS_core NF041261
RHS element core protein;
1-106 4.06e-25

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 104.31  E-value: 4.06e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794    1 MYYYHLDQLNTPRFVTNNKTEVVWENQADVYGYEESEANTtNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQD 80
Cdd:NF041261  1157 LHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENP-HHLQQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQD 1235

                           90       100
                   ....*....|....*....|....*.
gi 2532799794   81 PIGLVGGINHYQYAPNPVNWVDPFGL 106
Cdd:NF041261  1236 PIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RHS pfam03527
RHS protein;
2-32 4.28e-05

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 39.98  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2532799794   2 YYYHLDQLNTPRFVTNNKTEVVWENQADVYG 32
Cdd:pfam03527   2 YYYHTDHLGTPEELTDEAGEIVWSAEYDAWG 32
 
Name Accession Description Interval E-value
Ntox46 pfam15538
Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The ...
 122-258 1.47e-45

Bacterial toxin 46; A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system.


Pssm-ID: 406080  Cd Length: 157  Bit Score: 150.15  E-value: 1.47e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794 122 IKQRKLVAFEFYKSQGFKEEDIPSHLTGIDFAHPVEKVMIESGQVFYQFQSPGAPQGNYYSDDPNITPTQLGISPMGTNR 201
Cdd:pfam15538  21 IRGNQETAAKFFKSKDIDPADAEGYMNGLDFNHPVFTETIAPGKNLWQFQSPGAPQGMWYSLSPDVQPGELGINPLGQIF 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2532799794 202 ALNSIEPKIKGVYIAQEDTPALRSRAKAVDDFWSVRGESYPTEGGGTQYFTANKLAF 258
Cdd:pfam15538 101 AAETIEPKILNSYQSTEKVELLRSTAAPTDDFWSVKGQPYNAIGGAQQLFSAEKELF 157
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 29-106 4.32e-34

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 117.99  E-value: 4.32e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2532799794  29 DVYGYEESEantTNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQDPIGLVGGINHYQYAP-NPVNWVDPFGL 106
Cdd:TIGR03696   2 DPYGEVLSE---SGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYVGnNPVNWVDPLGL 77
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 5-108 6.38e-33

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 126.79  E-value: 6.38e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794    5 HLDQLNTPRFVTNNKTEVVWENQADVYGyeESEANTTNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQDPIGL 84
Cdd:COG3209    925 HTDHLGSVRALTDASGQVVWRYDYDPFG--NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGL 1002

                           90       100
                   ....*....|....*....|....*
gi 2532799794   85 VGGINHYQYA-PNPVNWVDPFGLSC 108
Cdd:COG3209   1003 AGGLNLYAYVgNNPVNYVDPLGLAA 1027
RHS_core NF041261
RHS element core protein;
1-106 4.06e-25

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 104.31  E-value: 4.06e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532799794    1 MYYYHLDQLNTPRFVTNNKTEVVWENQADVYGYEESEANTtNSFTQPIRFQGQYLDIESGLHYNRYRYYSPKQQRFINQD 80
Cdd:NF041261  1157 LHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENP-HHLQQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQD 1235

                           90       100
                   ....*....|....*....|....*.
gi 2532799794   81 PIGLVGGINHYQYAPNPVNWVDPFGL 106
Cdd:NF041261  1236 PIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RHS pfam03527
RHS protein;
2-32 4.28e-05

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 39.98  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2532799794   2 YYYHLDQLNTPRFVTNNKTEVVWENQADVYG 32
Cdd:pfam03527   2 YYYHTDHLGTPEELTDEAGEIVWSAEYDAWG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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