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Conserved domains on  [gi|2532876748|ref|WP_290292569|]
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SoxR reducing system RseC family protein [Lutimonas halocynthiae]

Protein Classification

SoxR reducing system RseC family protein( domain architecture ID 10515214)

SoxR reducing system RseC family protein, may play a role in the reduction of the iron-sulfur cluster regulatory protein SoxR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 9-133 2.81e-24

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


:

Pssm-ID: 461236  Cd Length: 130  Bit Score: 90.33  E-value: 2.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748   9 KITNSTITVSLEPNINCEGCKAKAACGASESSSKEIEIDNPNLIQKQAGQnfvlneEVAVVLNEELGLKAVFWAYLFPFM 88
Cdd:pfam04246   3 AVEGGTAWVEIERKSACGSCAARSGCKLGASGSKEKIIEVANPIGAKVGD------RVEVGIPESSLLKAALLVYLLPLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2532876748  89 LLVSVLVIASSFF--SEGLAGLIALSVLIPYYITLYILNAFFKKKFK 133
Cdd:pfam04246  77 GLILGALLGQALLggSELAAALGGLLGLALGFLILRLLDRRLKKKGK 123
 
Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 9-133 2.81e-24

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


Pssm-ID: 461236  Cd Length: 130  Bit Score: 90.33  E-value: 2.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748   9 KITNSTITVSLEPNINCEGCKAKAACGASESSSKEIEIDNPNLIQKQAGQnfvlneEVAVVLNEELGLKAVFWAYLFPFM 88
Cdd:pfam04246   3 AVEGGTAWVEIERKSACGSCAARSGCKLGASGSKEKIIEVANPIGAKVGD------RVEVGIPESSLLKAALLVYLLPLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2532876748  89 LLVSVLVIASSFF--SEGLAGLIALSVLIPYYITLYILNAFFKKKFK 133
Cdd:pfam04246  77 GLILGALLGQALLggSELAAALGGLLGLALGFLILRLLDRRLKKKGK 123
RseC COG3086
RseC, positive regulator of sigma E activity [Signal transduction mechanisms];
1-133 1.04e-22

RseC, positive regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442320  Cd Length: 149  Bit Score: 86.86  E-value: 1.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748   1 MKHSGAISKITNSTITVSLEPNINCEGCKAKAACGASESS----SKEIEIDNPNLIQKQAGQnfvlneEVAVVLNEELGL 76
Cdd:COG3086     2 IEETGTVVAVEGGTAWVETQRKSACGSCAAKSGCGTGLLSklfpSKEHRLEVPNPLGLKVGD------RVEVGIPESSLL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748  77 KAVFWAYLFPFMLLVSVLVIASSFF---SEGLAGLIALSVLIPYYITLYILNAFFKKKFK 133
Cdd:COG3086    76 KAALLVYLLPLLGLLLGALLGQALGpggSELLAALGGLLGLALGFLLARRLSRRLAKKSK 135
 
Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 9-133 2.81e-24

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


Pssm-ID: 461236  Cd Length: 130  Bit Score: 90.33  E-value: 2.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748   9 KITNSTITVSLEPNINCEGCKAKAACGASESSSKEIEIDNPNLIQKQAGQnfvlneEVAVVLNEELGLKAVFWAYLFPFM 88
Cdd:pfam04246   3 AVEGGTAWVEIERKSACGSCAARSGCKLGASGSKEKIIEVANPIGAKVGD------RVEVGIPESSLLKAALLVYLLPLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2532876748  89 LLVSVLVIASSFF--SEGLAGLIALSVLIPYYITLYILNAFFKKKFK 133
Cdd:pfam04246  77 GLILGALLGQALLggSELAAALGGLLGLALGFLILRLLDRRLKKKGK 123
RseC COG3086
RseC, positive regulator of sigma E activity [Signal transduction mechanisms];
1-133 1.04e-22

RseC, positive regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442320  Cd Length: 149  Bit Score: 86.86  E-value: 1.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748   1 MKHSGAISKITNSTITVSLEPNINCEGCKAKAACGASESS----SKEIEIDNPNLIQKQAGQnfvlneEVAVVLNEELGL 76
Cdd:COG3086     2 IEETGTVVAVEGGTAWVETQRKSACGSCAAKSGCGTGLLSklfpSKEHRLEVPNPLGLKVGD------RVEVGIPESSLL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2532876748  77 KAVFWAYLFPFMLLVSVLVIASSFF---SEGLAGLIALSVLIPYYITLYILNAFFKKKFK 133
Cdd:COG3086    76 KAALLVYLLPLLGLLLGALLGQALGpggSELLAALGGLLGLALGFLLARRLSRRLAKKSK 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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