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Conserved domains on  [gi|2533798448|ref|WP_290726672|]
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helix-turn-helix domain-containing protein [Archaeoglobus sp.]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-92 6.14e-11

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 54.10  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2533798448  16 ITKTLKMLARSGVCDVISSLKPGPRGFSQLMFET-KLNPGVLSRHLKALTEHAVVEKHSNS-------YGLTDKGRKLVE 87
Cdd:COG1733    12 VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPevpprveYSLTEKGRSLLP 91


                  ....*
gi 2533798448  88 ILEEI 92
Cdd:COG1733    92 VLDAL 96
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-92 6.14e-11

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 54.10  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2533798448  16 ITKTLKMLARSGVCDVISSLKPGPRGFSQLMFET-KLNPGVLSRHLKALTEHAVVEKHSNS-------YGLTDKGRKLVE 87
Cdd:COG1733    12 VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPevpprveYSLTEKGRSLLP 91


                  ....*
gi 2533798448  88 ILEEI 92
Cdd:COG1733    92 VLDAL 96
HTH_45 pfam14947
Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal ...
 30-97 7.71e-07

Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerization of this domain.


Pssm-ID: 405615 [Multi-domain]  Cd Length: 77  Bit Score: 42.98  E-value: 7.71e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2533798448 30 DVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKHSNSYGLTDKGRKLVEILEEISKTIK 97
Cdd:pfam14947 10 DILEACSNGGAKKTKIMYNANLSYKLLNKYLDMLVDNGLIKNDGGKYVLTEKGLELLEKLREFRELAK 77
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 20-94 2.83e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.82  E-value: 2.83e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2533798448 20 LKMLARSGVCDVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKHSNS----YGLTDkGRKLVEILEEISK 94
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGrrvyYSLTD-AERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-71 4.70e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 4.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2533798448  30 DVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEK 71
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVES 42
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-92 6.14e-11

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 54.10  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2533798448  16 ITKTLKMLARSGVCDVISSLKPGPRGFSQLMFET-KLNPGVLSRHLKALTEHAVVEKHSNS-------YGLTDKGRKLVE 87
Cdd:COG1733    12 VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPevpprveYSLTEKGRSLLP 91


                  ....*
gi 2533798448  88 ILEEI 92
Cdd:COG1733    92 VLDAL 96
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
30-97 1.92e-08

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 47.17  E-value: 1.92e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2533798448 30 DVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKH----SNSYGLTDKGRKLVEILEEISKTIK 97
Cdd:COG3432   12 DILEALKNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEddggRRIYRITEKGREFLEKYEEIKELLE 83
HTH_45 pfam14947
Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal ...
 30-97 7.71e-07

Winged helix-turn-helix; This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerization of this domain.


Pssm-ID: 405615 [Multi-domain]  Cd Length: 77  Bit Score: 42.98  E-value: 7.71e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2533798448 30 DVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKHSNSYGLTDKGRKLVEILEEISKTIK 97
Cdd:pfam14947 10 DILEACSNGGAKKTKIMYNANLSYKLLNKYLDMLVDNGLIKNDGGKYVLTEKGLELLEKLREFRELAK 77
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 25-63 1.11e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 38.96  E-value: 1.11e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2533798448 25 RSGVCDVISSLKPGPRGFSQLMFETKLNPGVLSRHLKAL 63
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKL 39
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 20-94 2.83e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.82  E-value: 2.83e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2533798448 20 LKMLARSGVCDVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKHSNS----YGLTDkGRKLVEILEEISK 94
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGrrvyYSLTD-AERLLALLESLLE 78
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
20-96 4.15e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 40.26  E-value: 4.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2533798448  20 LKMLARSGV-CDVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEKHSNSYGLTDKGRKLVEILEEISKTI 96
Cdd:COG4742     9 LDFLFLSEKrKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGEYELTTLGRLVVEEMEPLLDTL 86
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 31-94 1.97e-03

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 34.20  E-value: 1.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2533798448 31 VISSLKPGPRGFSQLmfeTKLNPG----VLSRHLKALTEHAVVEKHSNS-------YGLTDKGRKLVEILEEISK 94
Cdd:pfam01638 10 ILRELLDGKKRFSEL---KRAIPGitqkMLTQRLRELEQDGIINREVYPevppkveYSLTEKGRSLEPILQELCD 81
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-71 4.70e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 4.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2533798448  30 DVISSLKPGPRGFSQLMFETKLNPGVLSRHLKALTEHAVVEK 71
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVES 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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