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Conserved domains on  [gi|2534165765|ref|WP_291075645|]
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MULTISPECIES: 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein [unclassified Empedobacter]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein( domain architecture ID 11441209)

bifunctional 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein may play a role in fatty acid metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 5-306 4.96e-98

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 305.88  E-value: 4.96e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGL---TLESKVVRNRTAQTHLDAALksnpspiydka 81
Cdd:COG1250     2 IKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEAL---ERARARiakLLDKLVKKGKLTEEEADAAL----------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  82 faSRITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEdfQKHFCGTHF 161
Cdd:COG1250    68 --ARIT---PTTDLAALADADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKR--PERFIGLHF 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 162 FNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTGS 241
Cdd:COG1250   141 FNPVPLMPLVEVIRGPATSDETVATAVAFARR-LGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRL 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 242 ILGRPKtGTFKLGDLVGLDTAYNVTKGLQQNAPNDEMiqglKDSKFLDFLIENKFLGDKTKKGFY 306
Cdd:COG1250   220 GFGFPM-GPFELADLVGLDTALAVLEVLYEALGDPRY----RPPPLLKKLVEAGRLGRKTGRGFY 279
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 492-695 2.69e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


:

Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 112.65  E-value: 2.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRS--KMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWElnMAIKM 567
Cdd:cd06558     4 ERDGGVATITLNRpeKRNALSLEMLDELAAALDEAEADpdVRVVVLTGAGKAFCAGADLKELAALSDAGEEAR--AFIRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFALkd 642
Cdd:cd06558    82 LQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRlvgpaRARELLL-- 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2534165765 643 dvkvnhlrdnfmniaTAKVAtSAYEAKNMGIIREqdivVVNAERQIAEAKKHA 695
Cdd:cd06558   160 ---------------TGRRI-SAEEALELGLVDE----VVPDEELLAAALELA 192
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 5-306 4.96e-98

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 305.88  E-value: 4.96e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGL---TLESKVVRNRTAQTHLDAALksnpspiydka 81
Cdd:COG1250     2 IKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEAL---ERARARiakLLDKLVKKGKLTEEEADAAL----------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  82 faSRITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEdfQKHFCGTHF 161
Cdd:COG1250    68 --ARIT---PTTDLAALADADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKR--PERFIGLHF 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 162 FNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTGS 241
Cdd:COG1250   141 FNPVPLMPLVEVIRGPATSDETVATAVAFARR-LGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRL 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 242 ILGRPKtGTFKLGDLVGLDTAYNVTKGLQQNAPNDEMiqglKDSKFLDFLIENKFLGDKTKKGFY 306
Cdd:COG1250   220 GFGFPM-GPFELADLVGLDTALAVLEVLYEALGDPRY----RPPPLLKKLVEAGRLGRKTGRGFY 279
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 7-205 1.89e-47

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 166.56  E-value: 1.89e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   7 HVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALksnpspiydkafaSRI 86
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAAL-------------ARI 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  87 TvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEDFQkhFCGTHFFNPPR 166
Cdd:pfam02737  68 S---FTTDLAAAVDADLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPER--FIGLHFFNPPP 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2534165765 167 YLKLFEIIPTPQTDQSVVEFLQNYAsLFLGKTPVLCKDT 205
Cdd:pfam02737 143 LMPLVEVVRGEKTSPETVATTVELA-KKIGKTPVVVKDT 180
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 5-314 1.82e-42

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 156.43  E-value: 1.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALKsnpspiydkafas 84
Cdd:PLN02545    4 IKKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLG------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEDFQkhFCGTHFFNP 164
Cdd:PLN02545   71 RIR---CTTNLEELRDADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQ--VIGMHFMNP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 165 PRYLKLFEIIPTPQTDQSVVEFLQNYASLFlGKTPVLCKDTPGFIGNRVgvySMAKVME--LAQEIGL-TIEEVDtlTGS 241
Cdd:PLN02545  146 PPIMKLVEIIRGADTSDEVFDATKALAERF-GKTVVCSQDYPGFIVNRI---LMPMINEafYALYTGVaSKEDID--TGM 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 242 ILG--RPkTGTFKLGDLVGLDTAYNVTKGLQqnapndemiQGLKDSKF-----LDFLIENKFLGDKTKKGFYYKEIDKDG 314
Cdd:PLN02545  220 KLGtnHP-MGPLHLADFIGLDTCLSIMKVLH---------EGLGDSKYrpcplLVQYVDAGRLGRKSGRGVYHYDGKKRG 289
FadB TIGR02437
fatty oxidation complex, alpha subunit FadB; Members represent alpha subunit of ...
 5-314 4.36e-35

fatty oxidation complex, alpha subunit FadB; Members represent alpha subunit of multifunctional enzyme complex of the fatty acid degradation cycle. Activities include: enoyl-CoA hydratase (EC 4.2.1.17), dodecenoyl-CoA delta-isomerase activity (EC 5.3.3.8), 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3). A representative is E. coli FadB (SP:P21177). This model excludes the FadJ family represented by SP:P77399. [Fatty acid and phospholipid metabolism, Degradation]


Pssm-ID: 131490 [Multi-domain]  Cd Length: 714  Bit Score: 142.65  E-value: 4.36e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTpqeqaKGLTLESKVVRNRTAQTHLD----AALKSNPSPIYDK 80
Cdd:TIGR02437 313 VKQAAVLGAGIMGGGIAYQSASKGTPIVMKDINQHSLD-----LGLTEAAKLLNKQVERGRITpakmAGVLNGITPTLSY 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  81 AfasritvgnfdddfeKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAegRSEDFQKHFCGTH 160
Cdd:TIGR02437 388 A---------------GFDNVDIVVEAVVENPKVKAAVLAEVEQHVREDAILASNTSTISISLLA--KALKRPENFCGMH 450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 161 FFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEiGLTIEEVDTLTG 240
Cdd:TIGR02437 451 FFNPVHRMPLVEVIRGEKSSDETIATVVAYASK-MGKTPIVVNDCPGFFVNRVLFPYFGGFSKLLRD-GADFVRIDKVME 528

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2534165765 241 SILGRPkTGTFKLGDLVGLDTAYNVTKGLQQNAPnDEMIQGLKDSkfLDFLIENKFLGDKTKKGFYYKEIDKDG 314
Cdd:TIGR02437 529 KQFGWP-MGPAYLLDVVGIDTGHHAQAVMAEGFP-DRMGKDGRDA--IDALFEAKRLGQKNGKGFYAYEADKKG 598
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 492-695 2.69e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 112.65  E-value: 2.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRS--KMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWElnMAIKM 567
Cdd:cd06558     4 ERDGGVATITLNRpeKRNALSLEMLDELAAALDEAEADpdVRVVVLTGAGKAFCAGADLKELAALSDAGEEAR--AFIRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFALkd 642
Cdd:cd06558    82 LQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRlvgpaRARELLL-- 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2534165765 643 dvkvnhlrdnfmniaTAKVAtSAYEAKNMGIIREqdivVVNAERQIAEAKKHA 695
Cdd:cd06558   160 ---------------TGRRI-SAEEALELGLVDE----VVPDEELLAAALELA 192
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 492-791 6.29e-27

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 110.26  E-value: 6.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRS--KMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWELnmaIKM 567
Cdd:COG1024     4 EREGGVATITLNRpeKLNALSLEMLAELAAALDEAEADpdVRVVVLTGAGKAFCAGADLKELAAAADPEEARAF---ARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFALkd 642
Cdd:COG1024    81 LQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRlvglaRAKELLL-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 643 dvkvnhlrdnfmniaTAKVaTSAYEAKNMGIIREqdivVVNAERQIAEAKKHAIILAEAGytqpiqRKVEVLGKEAMgmf 722
Cdd:COG1024   159 ---------------TGRR-IDAEEALELGLVNR----VVPDDELLAAALALAARLAAGP------PLALAATKRAL--- 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2534165765 723 yvgtdsmvtgrfasdhdrlianklgyvmtggNLSESTYVSEQylLDLERETFLSLCGERKTLERIQHML 791
Cdd:COG1024   210 -------------------------------NAALEAPLDEA--LELEAEAFAELFASEDAREGIAAFL 245
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 490-617 5.70e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 63.73  E-value: 5.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 490 IQDLGDGIINIEFR--SKMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMimMMAAEQDWWELNMAI 565
Cdd:PRK06688    8 LVELEDGVLTITINrpDKKNALTAAMYQALADALEAAATDpaVRVVVLTGAGRAFSAGGDIKD--FPKAPPKPPDELAPV 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 566 KMFqdtmmrVRY---SSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK06688   86 NRF------LRAiaaLPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFA 134
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 496-616 6.60e-06

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 48.51  E-value: 6.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 496 GIINIEF--RSKMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIM--MMAAEQDWWElnmaikMFQ 569
Cdd:pfam00378   5 GVAVITLnrPEAVNALSAELITELIQALEKLRTDpsVRAVVLTGGDKAFCAGADLKEMYgeGPAHQALYRE------NVL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2534165765 570 DTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVE 616
Cdd:pfam00378  79 DLWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNE 125
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 504-617 2.58e-03

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 41.36  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 504 SKMNSLGGGV---LQGINKGIELAEKDYRGVVIGNQGDNFSVGANlamIMMMAAEQDWWELNMAIKMFQDTMMRVRYSSI 580
Cdd:TIGR02441  33 SKVNTLSKELfaeFKEVMNELWTNEAIKSAVLISGKPGSFVAGAD---IQMIAACKTAQEVTQLSQEGQEMFERIEKSQK 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2534165765 581 PVVVAPHGMTLGGGCEMSM--HADKIVAAAETYIGLVEV 617
Cdd:TIGR02441 110 PIVAAISGSCLGGGLELALacHYRIATKDRKTLLGLPEV 148
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 5-306 4.96e-98

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 305.88  E-value: 4.96e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGL---TLESKVVRNRTAQTHLDAALksnpspiydka 81
Cdd:COG1250     2 IKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEAL---ERARARiakLLDKLVKKGKLTEEEADAAL----------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  82 faSRITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEdfQKHFCGTHF 161
Cdd:COG1250    68 --ARIT---PTTDLAALADADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKR--PERFIGLHF 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 162 FNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTGS 241
Cdd:COG1250   141 FNPVPLMPLVEVIRGPATSDETVATAVAFARR-LGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRL 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 242 ILGRPKtGTFKLGDLVGLDTAYNVTKGLQQNAPNDEMiqglKDSKFLDFLIENKFLGDKTKKGFY 306
Cdd:COG1250   220 GFGFPM-GPFELADLVGLDTALAVLEVLYEALGDPRY----RPPPLLKKLVEAGRLGRKTGRGFY 279
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 7-205 1.89e-47

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 166.56  E-value: 1.89e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   7 HVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALksnpspiydkafaSRI 86
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAAL-------------ARI 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  87 TvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEDFQkhFCGTHFFNPPR 166
Cdd:pfam02737  68 S---FTTDLAAAVDADLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPER--FIGLHFFNPPP 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2534165765 167 YLKLFEIIPTPQTDQSVVEFLQNYAsLFLGKTPVLCKDT 205
Cdd:pfam02737 143 LMPLVEVVRGEKTSPETVATTVELA-KKIGKTPVVVKDT 180
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 5-314 1.82e-42

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 156.43  E-value: 1.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALKsnpspiydkafas 84
Cdd:PLN02545    4 IKKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLG------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEDFQkhFCGTHFFNP 164
Cdd:PLN02545   71 RIR---CTTNLEELRDADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQ--VIGMHFMNP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 165 PRYLKLFEIIPTPQTDQSVVEFLQNYASLFlGKTPVLCKDTPGFIGNRVgvySMAKVME--LAQEIGL-TIEEVDtlTGS 241
Cdd:PLN02545  146 PPIMKLVEIIRGADTSDEVFDATKALAERF-GKTVVCSQDYPGFIVNRI---LMPMINEafYALYTGVaSKEDID--TGM 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 242 ILG--RPkTGTFKLGDLVGLDTAYNVTKGLQqnapndemiQGLKDSKF-----LDFLIENKFLGDKTKKGFYYKEIDKDG 314
Cdd:PLN02545  220 KLGtnHP-MGPLHLADFIGLDTCLSIMKVLH---------EGLGDSKYrpcplLVQYVDAGRLGRKSGRGVYHYDGKKRG 289
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 5-306 2.77e-38

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 144.92  E-value: 2.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGltlesKVVRNRTAQTHLDAALKSnpspiydkafAS 84
Cdd:PRK06130    4 IQNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEGAL---ERARG-----VIERALGVYAPLGIASAG----------MG 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RItvgNFDDDFEK-IKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSedFQKHFCGTHFFN 163
Cdd:PRK06130   66 RI---RMEAGLAAaVSGADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVT--RPERFVGTHFFT 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 164 PPRYLKLFEII----PTPQTDQSVVEFLQNyaslfLGKTPVLC-KDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTL 238
Cdd:PRK06130  141 PADVIPLVEVVrgdkTSPQTVATTMALLRS-----IGKRPVLVkKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEV 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 239 TGSILGR--PKTGTFKLGDLVGLDTAYNVTKGLQQNAPNDEMIqglkdSKFLDFLIENKFLGDKTKKGFY 306
Cdd:PRK06130  216 VKWSLGIrlALTGPLEQRDMNGLDVHLAVASYLYQDLENRTTP-----SPLLEEKVEAGELGAKSGQGFY 280
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-309 1.55e-36

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 144.60  E-value: 1.55e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   1 MRRHVKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALksnpspiydk 80
Cdd:PRK08268    3 ALPSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAAL---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  81 afaSRITVGnfdDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEG--RSEdfqkHFCG 158
Cdd:PRK08268   73 ---ARLRPV---EALADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAAlkHPE----RVAG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 159 THFFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLFlGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTl 238
Cdd:PRK08268  143 LHFFNPVPLMKLVEVVSGLATDPAVADALYALARAW-GKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDA- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 239 tgsIL---GRPKTGTFKLGDLVGLDTAYNVTKGLQQnapndemiQGLKDSKFLDFLI-----ENKFLGDKTKKGFY-YKE 309
Cdd:PRK08268  221 ---ILreaAGFRMGPFELMDLIGLDVNHAVMESVYR--------QFYQEPRFRPSLIqqelvAAGRLGRKSGQGFYrYAD 289
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
5-314 2.79e-36

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 146.55  E-value: 2.79e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPR--ELTPQEQAKGLTleSKVVRNRTAQTHLDAALksnpspiydkaf 82
Cdd:PRK11730  313 VKQAAVLGAGIMGGGIAYQSASKGVPVIMKDINQKalDLGMTEAAKLLN--KQVERGKIDGAKMAGVL------------ 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  83 aSRITVG-NFDDdfekIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEG--RSEDfqkhFCGT 159
Cdd:PRK11730  379 -SSIRPTlDYAG----FERVDVVVEAVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKAlkRPEN----FCGM 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 160 HFFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRV-----GVYSMA-----------KVME 223
Cdd:PRK11730  450 HFFNPVHRMPLVEVIRGEKTSDETIATVVAYASK-MGKTPIVVNDCPGFFVNRVlfpyfAGFSQLlrdgadfrqidKVME 528

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 224 laqeigltieevdtltgSILGRPkTGTFKLGDLVGLDTAYNVTKGLQQNAPnDEMIQGLKDSkfLDFLIENKFLGDKTKK 303
Cdd:PRK11730  529 -----------------KQFGWP-MGPAYLLDVVGIDTAHHAQAVMAEGFP-DRMKKDYRDA--IDVLFEAKRFGQKNGK 587

                         330
                  ....*....|.
gi 2534165765 304 GFYYKEIDKDG 314
Cdd:PRK11730  588 GFYRYEEDKKG 598
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
5-318 1.18e-35

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 136.84  E-value: 1.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALksnpspiydkafaS 84
Cdd:PRK09260    1 IEKLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLESAQQEIASIFEQGVARGKLTEAARQAAL-------------A 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RITVGNfdDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEG--RSEdfqkHFCGTHFF 162
Cdd:PRK09260   68 RLSYSL--DLKAAVADADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFtkRPE----RVIAMHFF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 163 NPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTGSI 242
Cdd:PRK09260  142 NPVHKMKLVELIRGLETSDETVQVAKEVAEQ-MGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLG 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2534165765 243 LGRPkTGTFKLGDLVGLDTAYNVTKGLQQNapndeMIQGLKDSKFLDFLIENKFLGDKTKKGFYykEIDKDGNTNR 318
Cdd:PRK09260  221 LNFP-MGPLELGDLVGLDTRLNNLKYLHET-----LGEKYRPAPLLEKYVKAGRLGRKTGRGVY--DYTNRENVPG 288
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 5-306 1.50e-35

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 136.25  E-value: 1.50e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMvpreltpQEQA--KGLT-----LESKVVRNRTAQTHLDAALksnpspi 77
Cdd:PRK05808    3 IQKIGVIGAGTMGNGIAQVCAVAGYDVVMVDI-------SDAAvdRGLAtitksLDRLVKKGKMTEADKEAAL------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  78 ydkafaSRITVGNfddDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEG--RSEdfqkH 155
Cdd:PRK05808   69 ------ARITGTT---DLDDLKDADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAAtkRPD----K 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 156 FCGTHFFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEV 235
Cdd:PRK05808  136 VIGMHFFNPVPVMKLVEIIRGLATSDATHEAVEALAKK-IGKTPVEVKNAPGFVVNRILIPMINEAIFVLAEGVATAEDI 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2534165765 236 DtlTGSILG--RPkTGTFKLGDLVGLDTAYNVTkglqqnapnDEMIQGLKDSKF-----LDFLIENKFLGDKTKKGFY 306
Cdd:PRK05808  215 D--EGMKLGcnHP-IGPLALADLIGLDTCLAIM---------EVLYEGFGDSKYrpcplLRKMVAAGWLGRKTGRGFY 280
FadB TIGR02437
fatty oxidation complex, alpha subunit FadB; Members represent alpha subunit of ...
 5-314 4.36e-35

fatty oxidation complex, alpha subunit FadB; Members represent alpha subunit of multifunctional enzyme complex of the fatty acid degradation cycle. Activities include: enoyl-CoA hydratase (EC 4.2.1.17), dodecenoyl-CoA delta-isomerase activity (EC 5.3.3.8), 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3). A representative is E. coli FadB (SP:P21177). This model excludes the FadJ family represented by SP:P77399. [Fatty acid and phospholipid metabolism, Degradation]


Pssm-ID: 131490 [Multi-domain]  Cd Length: 714  Bit Score: 142.65  E-value: 4.36e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTpqeqaKGLTLESKVVRNRTAQTHLD----AALKSNPSPIYDK 80
Cdd:TIGR02437 313 VKQAAVLGAGIMGGGIAYQSASKGTPIVMKDINQHSLD-----LGLTEAAKLLNKQVERGRITpakmAGVLNGITPTLSY 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  81 AfasritvgnfdddfeKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAegRSEDFQKHFCGTH 160
Cdd:TIGR02437 388 A---------------GFDNVDIVVEAVVENPKVKAAVLAEVEQHVREDAILASNTSTISISLLA--KALKRPENFCGMH 450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 161 FFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEiGLTIEEVDTLTG 240
Cdd:TIGR02437 451 FFNPVHRMPLVEVIRGEKSSDETIATVVAYASK-MGKTPIVVNDCPGFFVNRVLFPYFGGFSKLLRD-GADFVRIDKVME 528

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2534165765 241 SILGRPkTGTFKLGDLVGLDTAYNVTKGLQQNAPnDEMIQGLKDSkfLDFLIENKFLGDKTKKGFYYKEIDKDG 314
Cdd:TIGR02437 529 KQFGWP-MGPAYLLDVVGIDTGHHAQAVMAEGFP-DRMGKDGRDA--IDALFEAKRLGQKNGKGFYAYEADKKG 598
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 5-306 2.59e-33

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 130.13  E-value: 2.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTpqeqaKGLT-----LESKVVRNRTAQTHLDAALKsnpspiyd 79
Cdd:PRK07530    4 IKKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLE-----AGLAtingnLARQVAKGKISEEARAAALA-------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  80 kafasRITVGnfdDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEgrSEDFQKHFCGT 159
Cdd:PRK07530   71 -----RISTA---TDLEDLADCDLVIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLAS--ATDRPERFIGI 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 160 HFFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLfLGKTPVLCKDTPGFIGNRV-------GVYSmakvmeLAQEIGlTI 232
Cdd:PRK07530  141 HFMNPVPVMKLVELIRGIATDEATFEAAKEFVTK-LGKTITVAEDFPAFIVNRIllpmineAIYT------LYEGVG-SV 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 233 EEVDTLTGsiLG--RPkTGTFKLGDLVGLDTAYNVTKGLQqnapndemiQGLKDSKF-----LDFLIENKFLGDKTKKGF 305
Cdd:PRK07530  213 EAIDTAMK--LGanHP-MGPLELADFIGLDTCLSIMQVLH---------DGLADSKYrpcplLVKYVEAGWLGRKTGRGF 280


                  .
gi 2534165765 306 Y 306
Cdd:PRK07530  281 Y 281
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-306 4.21e-33

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 129.34  E-value: 4.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   1 MRRHVKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALksnpspiydk 80
Cdd:PRK07819    1 MSDAIQRVGVVGAGQMGAGIAEVCARAGVDVLVFETTEELATAGRNRIEKSLERAVSRGKLTERERDAAL---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  81 afaSRITvgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNF-RKPGTLVTSNTSGIPIH--LMAEGRSEdfqkHFC 157
Cdd:PRK07819   71 ---ARLR---FTTDLGDFADRQLVIEAVVEDEAVKTEIFAELDKVvTDPDAVLASNTSSIPIMklAAATKRPG----RVL 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 158 GTHFFNPPRYLKLFEIIPTPQTDQSVVEFLQNYASLFLGKTPVLCKDTPGFIGNRVGV-YSMAKVMELaqEIGL-TIEEV 235
Cdd:PRK07819  141 GLHFFNPVPVLPLVELVPTLVTSEATVARAEEFASDVLGKQVVRAQDRSGFVVNALLVpYLLSAIRMV--ESGFaTAEDI 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2534165765 236 DtlTGSILG--RPkTGTFKLGDLVGLDTAYNVTkglqqnapnDEMIQGLKDSKF-----LDFLIENKFLGDKTKKGFY 306
Cdd:PRK07819  219 D--KAMVLGcaHP-MGPLRLSDLVGLDTVKAIA---------DSMYEEFKEPLYappplLLRMVEAGLLGKKSGRGFY 284
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 2-327 6.70e-31

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 129.96  E-value: 6.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   2 RRHVKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELTPQEQAKGLTLESKVVRNRTAQTHLDAALkSNPSPIYDka 81
Cdd:TIGR02441 332 QRPVKTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKGLNKKVKRKKITSLERDSIL-SNLTPTLD-- 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  82 fasritvgnfdddFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSEdfQKHFCGTHF 161
Cdd:TIGR02441 409 -------------YSGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSR--PEKVIGMHY 473

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 162 FNPPRYLKLFEIIPTPQTDQsvvEFLQNYASLFL--GKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEiGLTIEEVDTLT 239
Cdd:TIGR02441 474 FSPVDKMQLLEIITHDGTSK---DTLASAVAVGLkqGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQE-GVDPKKLDKLT 549

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 240 GSiLGRPkTGTFKLGDLVGLDTAYNVTKGLQQnAPNDEMIQGlkDSKFLDFLIENKFLGDKTKKGFYykeIDKDGNTNRF 319
Cdd:TIGR02441 550 TK-FGFP-VGAATLADEVGVDVAEHVAEDLGK-AFGERFGGG--SAELLSELVKAGFLGRKSGKGIF---IYQEGKKGSK 621


                  ....*...
gi 2534165765 320 ALNLDTLE 327
Cdd:TIGR02441 622 KVNSDADE 629
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 5-303 8.67e-30

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 119.98  E-value: 8.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGLTLESKVVRNRTAQthldaalKSNPSPIYDKAFAS 84
Cdd:PRK06035    3 IKVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEIL---KNAMELIESGPYGLRNLVE-------KGKMSEDEAKAIMA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RITVGNfddDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEGRSedFQKHFCGTHFFNP 164
Cdd:PRK06035   73 RIRTST---SYESLSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALE--RKDRFIGMHWFNP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 165 PRYLKLFEII----PTPQTDQSVVEFlqnyaSLFLGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTG 240
Cdd:PRK06035  148 APVMKLIEVVraalTSEETFNTTVEL-----SKKIGKIPIEVADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCK 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2534165765 241 SILGRPkTGTFKLGDLVGLDTAYNVTKGLQQNAPNDEMIQGLKdskfLDFLIENKFLGDKTKK 303
Cdd:PRK06035  223 LAFGFP-MGPFELMDIIGIDTVYHIAEYLYEETGDPQFIPPNS----LKQMVLNGYVGDKKVK 280
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 492-695 2.69e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 112.65  E-value: 2.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRS--KMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWElnMAIKM 567
Cdd:cd06558     4 ERDGGVATITLNRpeKRNALSLEMLDELAAALDEAEADpdVRVVVLTGAGKAFCAGADLKELAALSDAGEEAR--AFIRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFALkd 642
Cdd:cd06558    82 LQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRlvgpaRARELLL-- 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2534165765 643 dvkvnhlrdnfmniaTAKVAtSAYEAKNMGIIREqdivVVNAERQIAEAKKHA 695
Cdd:cd06558   160 ---------------TGRRI-SAEEALELGLVDE----VVPDEELLAAALELA 192
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
5-306 9.45e-28

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 113.88  E-value: 9.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGltlesKVVRNRTAQTHLDAALKSNPSpiyDKAFAs 84
Cdd:PRK08293    3 IKNVTVAGAGVLGSQIAFQTAFHGFDVTIYDISDEAL---EKAKE-----RIAKLADRYVRDLEATKEAPA---EAALN- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  85 RITVgnFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAE--GRSEdfqkHFCGTHFF 162
Cdd:PRK08293   71 RITL--TTDLAEAVKDADLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEatGRPE----KFLALHFA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 163 NPPRYLKLFEIIPTPQTDQ----SVVEFLQNyaslfLGKTP-VLCKDTPGFIGNRVGVYSMAKVMEL-AQEIGlTIEEVD 236
Cdd:PRK08293  145 NEIWKNNTAEIMGHPGTDPevfdTVVAFAKA-----IGMVPiVLKKEQPGYILNSLLVPFLSAALALwAKGVA-DPETID 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2534165765 237 TLTGSILGRPKtGTFKLGDLVGLDTAYNVTKGlQQNAPNDEMIQGLKD--SKFLDfliENKfLGDKTKKGFY 306
Cdd:PRK08293  219 KTWMIATGAPM-GPFGILDIVGLDTAYNITSN-WAEATDDENAKKAAAllKEYID---KGK-LGVATGEGFY 284
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 492-791 6.29e-27

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 110.26  E-value: 6.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRS--KMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWELnmaIKM 567
Cdd:COG1024     4 EREGGVATITLNRpeKLNALSLEMLAELAAALDEAEADpdVRVVVLTGAGKAFCAGADLKELAAAADPEEARAF---ARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFALkd 642
Cdd:COG1024    81 LQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRlvglaRAKELLL-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 643 dvkvnhlrdnfmniaTAKVaTSAYEAKNMGIIREqdivVVNAERQIAEAKKHAIILAEAGytqpiqRKVEVLGKEAMgmf 722
Cdd:COG1024   159 ---------------TGRR-IDAEEALELGLVNR----VVPDDELLAAALALAARLAAGP------PLALAATKRAL--- 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2534165765 723 yvgtdsmvtgrfasdhdrlianklgyvmtggNLSESTYVSEQylLDLERETFLSLCGERKTLERIQHML 791
Cdd:COG1024   210 -------------------------------NAALEAPLDEA--LELEAEAFAELFASEDAREGIAAFL 245
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
3-306 4.27e-23

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 104.98  E-value: 4.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   3 RHVKHVTVLGSGVMGSGIAC---HFANIGVEVlmldmvpRELTPQEQAKGLTLESKVVRNRTAQTHLDAALKSNPSpiyd 79
Cdd:PRK11154  307 RPVNKVGVLGGGLMGGGIAYvtaTKAGLPVRI-------KDINPQGINHALKYSWDLLDKKVKRRHLKPSERDKQM---- 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  80 kafaSRITVGNfddDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIHLMAEG--RSEDfqkhFC 157
Cdd:PRK11154  376 ----ALISGTT---DYRGFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAaaRPEQ----VI 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 158 GTHFFNPPRYLKLFEIIPT----PQTDQSVVEFLQNYaslflGKTPVLCKDTPGFIGNRVgvysMAKVMELAQEIGLTIE 233
Cdd:PRK11154  445 GLHYFSPVEKMPLVEVIPHaktsAETIATTVALAKKQ-----GKTPIVVRDGAGFYVNRI----LAPYINEAARLLLEGE 515

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 234 EVDTLTGSIL--GRPkTGTFKLGDLVGLDTAYNVTKGLQqnapnDEMIQGLKDSKFLDFLIENKFLGDKTKKGFY 306
Cdd:PRK11154  516 PIEHIDAALVkfGFP-VGPITLLDEVGIDVGTKIIPILE-----AALGERFSAPAAFDKLLNDDRKGRKNGRGFY 584
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 16-237 1.11e-19

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 90.89  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  16 MGSGIACHFANIGVEVLMLDMVPRelTPQEQAK---------GLTLESKVVRNRTAQTHLDAALksnpspiydkafaSRI 86
Cdd:PRK08269    1 MGQGIALAFAFAGHDVTLIDFKPR--DAAGWRAldaearaeiERTLAALVALGRIDAAQADAVL-------------ARI 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  87 TVGNFDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPIhlmaegrsEDFQKH------FCGTH 160
Cdd:PRK08269   66 AVVARDGAADALADADLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLV--------TDLQRHvahperFLNAH 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2534165765 161 FFNPPRYLKLFEIIPTPQTDQSVVEFLqnyASLF--LGKTPVLCKDTPGFIGNRVGVYSMAKVMELAQEIGLTIEEVDT 237
Cdd:PRK08269  138 WLNPAYLMPLVEVSPSDATDPAVVDRL---AALLerIGKVPVVCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDK 213
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 207-306 2.86e-15

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 71.86  E-value: 2.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 207 GFIGNRVGVYSMAKVMELAQEIGLTIEEVDTLTGSILGRPkTGTFKLGDLVGLDTAYNVTKGLQQNAPNDemiqGLKDSK 286
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLP-MGPFELSDLVGLDVGYHILEVLAEEFGDR----AYRPPP 75

                          90       100
                  ....*....|....*....|
gi 2534165765 287 FLDFLIENKFLGDKTKKGFY 306
Cdd:pfam00725  76 LLEKLVEAGRLGRKTGKGFY 95
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 7-213 8.68e-15

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 75.85  E-value: 8.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   7 HVTVLGSGVMGSGIACHFANIGVEVLMLDMVPRELtpqEQAKGLTLEskvVRNRTAqthlDAALKSNPSPiydKAFASRI 86
Cdd:PRK06129    4 SVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAA---AAAPAYIAG---RLEDLA----AFDLLDGEAP---DAVLARI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  87 TVGnfDDDFEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGIPihlmaegrSEDFQKHFCG------TH 160
Cdd:PRK06129   71 RVT--DSLADAVADADYVQESAPENLELKRALFAELDALAPPHAILASSTSALL--------ASAFTEHLAGrerclvAH 140

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2534165765 161 FFNPPRYLKLFEIIPTPQTDQSVVE----FLQNyaslfLGKTPVLC-KDTPGFIGNRV 213
Cdd:PRK06129  141 PINPPYLIPVVEVVPAPWTAPATLAraeaLYRA-----AGQSPVRLrREIDGFVLNRL 193
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 490-617 5.70e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 63.73  E-value: 5.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 490 IQDLGDGIINIEFR--SKMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMimMMAAEQDWWELNMAI 565
Cdd:PRK06688    8 LVELEDGVLTITINrpDKKNALTAAMYQALADALEAAATDpaVRVVVLTGAGRAFSAGGDIKD--FPKAPPKPPDELAPV 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 566 KMFqdtmmrVRY---SSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK06688   86 NRF------LRAiaaLPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFA 134
PRK07066 PRK07066
L-carnitine dehydrogenase;
5-213 2.45e-09

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 59.46  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   5 VKHVTVLGSGVMGSGIACHFANIGVEVLMLDmvpreltPQEQAKgltlesKVVRNRTAQThLDAALKSNPSPIYDKA--- 81
Cdd:PRK07066    7 IKTFAAIGSGVIGSGWVARALAHGLDVVAWD-------PAPGAE------AALRANVANA-WPALERQGLAPGASPArlr 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  82 FASRITvgnfdddfEKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSG-IPIHLMAegRSEDFQKHFCGtH 160
Cdd:PRK07066   73 FVATIE--------ACVADADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGlLPTDFYA--RATHPERCVVG-H 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 161 FFNPPRYLKLFEIIPTPQTDQSVVE-FLQNYASlfLGKTPV-LCKDTPGFIGNRV 213
Cdd:PRK07066  142 PFNPVYLLPLVEVLGGERTAPEAVDaAMGIYRA--LGMRPLhVRKEVPGFIADRL 194
PRK07531 PRK07531
carnitine 3-dehydrogenase;
4-212 3.89e-09

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 59.75  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765   4 HVKHVTVLGSGVMGSGIACHFANIGVEVLMLDmvpreltPQEQAKgltleskvvrnRTAQTHLDAALKSNPSpIYDKAFA 83
Cdd:PRK07531    3 MIMKAACIGGGVIGGGWAARFLLAGIDVAVFD-------PHPEAE-----------RIIGEVLANAERAYAM-LTDAPLP 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765  84 SRITVgNFDDDF-EKIKNSDWVIEVVIERLDIKQSIFERVDNFRKPGTLVTSNTSGI-PIHLMAEGRSEDfqkHFCGTHF 161
Cdd:PRK07531   64 PEGRL-TFCASLaEAVAGADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFlPSDLQEGMTHPE---RLFVAHP 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2534165765 162 FNPPRYLKLFEIIPT----PQTDQSVVEFLQNyaslfLGKTPV-LCKDTPGFIGNR 212
Cdd:PRK07531  140 YNPVYLLPLVELVGGgktsPETIRRAKEILRE-----IGMKPVhIAKEIDAFVGDR 190
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 495-616 8.52e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 57.34  E-value: 8.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 495 DGIINIEF-RSKMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWELNmaiKMFQDT 571
Cdd:PRK07658   10 DHVAVITLnHPPANALSSQVLHELSELLDQVEKDdnVRVVVIHGEGRFFSAGADIKEFTSVTEAEQATELA---QLGQVT 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2534165765 572 MMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVE 616
Cdd:PRK07658   87 FERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPE 131
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
493-617 5.96e-07

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 52.94  E-value: 5.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 493 LGDGIINIEFRSK--MNSLGGGVLQGINKGIEL--AEKDYRGVVIGNQGDNFSVGAN----LAMIMMMAAEQDWWeLNMA 564
Cdd:PRK11730   13 LEDGIAELVFDAPgsVNKLDRATLASLGEALDAleAQSDLKGLLLTSAKDAFIVGADitefLSLFAAPEEELSQW-LHFA 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2534165765 565 IKMFQdtmmrvRYSSIPV--VVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK11730   92 NSIFN------RLEDLPVptVAAINGYALGGGCECVLATDYRVASPDARIGLPET 140
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 524-699 6.33e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 51.59  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 524 AEKDYRGVVIGNQGDNFSVGANLAMimMMAAEqdwwelnmAIKMFQDTMMRVrYSSI-----PVVVAPHGMTLGGGCEMS 598
Cdd:PRK08138   49 EDPDIRAIVLTGGEKVFAAGADIKE--FATAG--------AIEMYLRHTERY-WEAIaqcpkPVIAAVNGYALGGGCELA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 599 MHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFARRATEFalkddvkvnhlrdNFMNIATAKVATSAYEAKNMGIIREqd 678
Cdd:PRK08138  118 MHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKF-------------KAMRMALTGCMVPAPEALAIGLVSE-- 182

                         170       180
                  ....*....|....*....|.
gi 2534165765 679 ivVVNAERQIAEAKKHAIILA 699
Cdd:PRK08138  183 --VVEDEQTLPRALELAREIA 201
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
492-616 9.60e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 50.79  E-value: 9.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFR--SKMNSLGGGVLQGINKGIELAEKDYRGVVIGNQGDNFSVGANLAMimmmAAEQDWWELNMAIKMFQ 569
Cdd:PRK08150    7 ELDGGVATIGLNrpAKRNALNDGLIAALRAAFARLPEGVRAVVLHGEGDHFCAGLDLSE----LRERDAGEGMHHSRRWH 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2534165765 570 DTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVE 616
Cdd:PRK08150   83 RVFDKIQYGRVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPE 129
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 496-616 6.60e-06

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 48.51  E-value: 6.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 496 GIINIEF--RSKMNSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMIM--MMAAEQDWWElnmaikMFQ 569
Cdd:pfam00378   5 GVAVITLnrPEAVNALSAELITELIQALEKLRTDpsVRAVVLTGGDKAFCAGADLKEMYgeGPAHQALYRE------NVL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2534165765 570 DTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVE 616
Cdd:pfam00378  79 DLWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNE 125
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
505-617 2.92e-05

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 47.58  E-value: 2.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 505 KMNSLGGGVLQGINKGIELAEKD--YRGVV-IGNQGDNFSVGANlamIMMMAAEQDWWELNMAIKMFQDTMMRVRYSSIP 581
Cdd:PRK11154   27 KMNTLKAEFAEQVRAILKQLREDkeLKGVVfISGKPDNFIAGAD---INMLAACKTAQEAEALARQGQQLFAEIEALPIP 103

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2534165765 582 VVVAPHGMTLGGGCEMSMHADKIVAA--AETYIGLVEV 617
Cdd:PRK11154  104 VVAAIHGACLGGGLELALACHYRVCTddPKTVLGLPEV 141
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
505-617 3.50e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 46.41  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 505 KMNSLGGGVLQGINKGIEL--AEKDYRGVVIGNQGDNFSVGANLA--MIMMMAAEQDWWELNMAIK-MFQDTMMRVRYSS 579
Cdd:PRK07509   23 KMNALDFAMFEELIATIKRlkKDRGIRAVILSGEGGAFCAGLDVKsvASSPGNAVKLLFKRLPGNAnLAQRVSLGWRRLP 102

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2534165765 580 IPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK07509  103 VPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEA 140
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 507-617 4.26e-05

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 45.91  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 507 NSLGGGVLQGINKGIELAEKD--YRGVVIGNQGDNFSVGANLAMImmmaAEQDwwelnmAIKMFQDTmmRVRY------S 578
Cdd:PRK09674   24 NALNNALLTQLVNELEAAATDtsIGVCVITGNARFFAAGADLNEM----AEKD------LAATLNDP--RPQLwqrlqaF 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2534165765 579 SIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK09674   92 NKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEI 130
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 489-674 5.75e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 45.50  E-value: 5.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 489 SIQDLGDGIINIEFRSKMNSLGGGVL---QGINKGIELaEKDYRGVVIGNQGDN-FSVGANLAMIMMMAAEQdwweLNMA 564
Cdd:PRK07657    8 DYVTPHVVKITLNRPRAANALSLALLeelQNILTQINE-EANVRVVILTGAGEKaFCAGADLKERAGMNEEQ----VRHA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 565 IKMFQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEVGVGLIPGGGGSKEFAR-----RATEFa 639
Cdd:PRK07657   83 VSLIRTTMEMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRligvgRAKEL- 161

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2534165765 640 lkddvkvnhlrdnfmnIATAKvATSAYEAKNMGII 674
Cdd:PRK07657  162 ----------------IYTGR-RISAQEAKEIGLV 179
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
580-617 4.55e-04

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 42.65  E-value: 4.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2534165765 580 IPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK07938   95 VPVIAAVHGFCLGGGIGLVGNADVIVASDDATFGLPEV 132
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
492-615 5.67e-04

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 42.41  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 492 DLGDGIINIEFRSKMNSLGGGVLQGINKGIELAEKDY---RGVVIGNQGDNFSVGANLAMIMMMAAEQD-WWELNMAI-K 566
Cdd:PRK05981   11 DGGVAILTLDHPEVMNAVSIDMLGGLAEALDAIEDGKaevRCLVLTGAGRGFCTGANLQGRGSGGRESDsGGDAGAALeT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2534165765 567 MFQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETY-------IGLV 615
Cdd:PRK05981   91 AYHPFLRRLRNLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYflqafrrIGLV 146
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
496-617 1.33e-03

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 41.27  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 496 GIINIEFRSKMNSLGGGVLQGINKGIELAEKD---YRGVVIGNQGDNFSVGANLAMIMMMAAEQDWWELNMAIKMFQdtm 572
Cdd:PRK05809   15 AVVTINRPKALNALNSETLKELDTVLDDIENDdnvYAVILTGAGEKAFVAGADISEMKDLNEEEGRKFGLLGNKVFR--- 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2534165765 573 mRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIGLVEV 617
Cdd:PRK05809   92 -KLENLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEV 135
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
494-612 1.55e-03

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 41.16  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 494 GDGIINIEFRS--KMNSLGGGV---LQGINKGIElAEKDYRGVVIGNQGDNFSVGANLAMIMMMAAEQD-----WWELnm 563
Cdd:PRK07327   19 PPGVLEIVLNGpgALNAADARMhreLADIWRDVD-RDPDVRVVLIRGEGKAFSAGGDLALVEEMADDFEvrarvWREA-- 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2534165765 564 aikmfQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYI 612
Cdd:PRK07327   96 -----RDLVYNVINCDKPIVSAIHGPAVGAGLVAALLADISIAAKDARI 139
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 504-617 2.58e-03

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 41.36  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 504 SKMNSLGGGV---LQGINKGIELAEKDYRGVVIGNQGDNFSVGANlamIMMMAAEQDWWELNMAIKMFQDTMMRVRYSSI 580
Cdd:TIGR02441  33 SKVNTLSKELfaeFKEVMNELWTNEAIKSAVLISGKPGSFVAGAD---IQMIAACKTAQEVTQLSQEGQEMFERIEKSQK 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2534165765 581 PVVVAPHGMTLGGGCEMSM--HADKIVAAAETYIGLVEV 617
Cdd:TIGR02441 110 PIVAAISGSCLGGGLELALacHYRIATKDRKTLLGLPEV 148
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
524-617 3.83e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 39.96  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534165765 524 AEKDYRGVVIGNQGDNFSVGANLAMIMMMAAE-------QDWWELNMAIKMFQDTMMRVRYSSIPVVVAPHGMTLGGGCE 596
Cdd:PRK06142   47 ADPEVRAVVLSGSGKHFSYGIDLPAMAGVFGQlgkdglaRPRTDLRREILRLQAAINAVADCRKPVIAAVQGWCIGGGVD 126

                          90       100
                  ....*....|....*....|.
gi 2534165765 597 MSMHADKIVAAAETYIGLVEV 617
Cdd:PRK06142  127 LISACDMRYASADAKFSVREV 147
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
568-613 4.04e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 40.03  E-value: 4.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2534165765 568 FQDTMMRVRYSSIPVVVAPHGMTLGGGCEMSMHADKIVAAAETYIG 613
Cdd:PRK08272  116 FVRGFMSLWHAHKPTVAKVHGYCVAGGTDIALHCDQVIAADDAKIG 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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