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Conserved domains on  [gi|2536127730|ref|WP_292887360|]
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MoxR family ATPase [Methanobrevibacter sp. UBA212]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 13-245 3.31e-63

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 200.39  E-value: 3.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  13 KMLLEESYVSNTEISTTLYLSFLLGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEGITFEQIVGEWNYQKQllhl 92
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ---- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  93 eaarndsnnvdeiFDDEFFIRRSLLNaflndkdSVLLIDEIDKADEEVESFLLQALGEQEITInDLGTFQLKNDLIVILT 172
Cdd:COG0714    83 -------------TGEFEFRPGPLFA-------NVLLADEINRAPPKTQSALLEAMEERQVTI-PGGTYKLPEPFLVIAT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 173 SN-----SQRSLLDETKDRCLF-LYIPYPTVEREIEIVKSKLPG-------------------------VEDETVSYVVK 221
Cdd:COG0714   142 QNpieqeGTYPLPEAQLDRFLLkLYIGYPDAEEEREILRRHTGRhlaevepvlspeellalqelvrqvhVSEAVLDYIVD 221

                         250       260
                  ....*....|....*....|....*
gi 2536127730 222 LVHQIRNLN-LMKKPSVRGTVDWVR 245
Cdd:COG0714   222 LVRATREHPdLRKGPSPRASIALLR 246
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 13-245 3.31e-63

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 200.39  E-value: 3.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  13 KMLLEESYVSNTEISTTLYLSFLLGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEGITFEQIVGEWNYQKQllhl 92
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ---- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  93 eaarndsnnvdeiFDDEFFIRRSLLNaflndkdSVLLIDEIDKADEEVESFLLQALGEQEITInDLGTFQLKNDLIVILT 172
Cdd:COG0714    83 -------------TGEFEFRPGPLFA-------NVLLADEINRAPPKTQSALLEAMEERQVTI-PGGTYKLPEPFLVIAT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 173 SN-----SQRSLLDETKDRCLF-LYIPYPTVEREIEIVKSKLPG-------------------------VEDETVSYVVK 221
Cdd:COG0714   142 QNpieqeGTYPLPEAQLDRFLLkLYIGYPDAEEEREILRRHTGRhlaevepvlspeellalqelvrqvhVSEAVLDYIVD 221

                         250       260
                  ....*....|....*....|....*
gi 2536127730 222 LVHQIRNLN-LMKKPSVRGTVDWVR 245
Cdd:COG0714   222 LVRATREHPdLRKGPSPRASIALLR 246
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 39-187 1.14e-15

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 71.94  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  39 PMLIEGPPGVGKTELAKVIAKAFDRD-FFRIQCYEGITFEQIVGEWNYQKQLlhleAARNDSnnvdeifddeffirrSLL 117
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRpVFYVQLTRDTTEEDLFGRRNIDPGG----ASWVDG---------------PLV 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2536127730 118 NAFLNDKdsVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQLK--NDLIVILTSNSQRSLLDE----TKDRC 187
Cdd:pfam07728  62 RAAREGE--IAVLDEINRANPDVLNSLLSLLDERRLLLPDGGELVKAapDGFRLIATMNPLDRGLNElspaLRSRF 135
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 36-182 8.25e-12

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 61.92  E-value: 8.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  36 LGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEgiTFEQIVGEwnyqkqllhLEAarndsnNVDEIFDDeffIRRS 115
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSS--LLSKYVGE---------SEK------NLRKIFER---ARRL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536127730 116 llnaflndKDSVLLIDEIDKA------------DEEVESFLLQALGEQEITindlgtfqlkNDLIVILTSNsQRSLLDE 182
Cdd:cd19481    85 --------APCILFIDEIDAIgrkrdssgesgeLRRVLNQLLTELDGVNSR----------SKVLVIAATN-RPDLLDP 144
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 37-181 8.41e-11

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.92  E-value: 8.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730   37 GKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIqcyegitfEQIVGEWNYQKQLLHLEAARNDSNNVDEIFDDEFFIRRSL 116
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGV--------IYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALAL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2536127730  117 LNAFLNDkdsVLLIDEIDKADEEVESFLLQALGEQEITINdlgtFQLKNDLIVILTSNSQRSLLD 181
Cdd:smart00382  74 ARKLKPD---VLILDEITSLLDAEQEALLLLLEELRLLLL----LKSEKNLTVILTTNDEKDLGP 131
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 44-68 2.09e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 48.54  E-value: 2.09e-06
                          10        20
                  ....*....|....*....|....*
gi 2536127730  44 GPPGVGKTELAKVIAKAFDRDFFRI 68
Cdd:PRK13342   43 GPPGTGKTTLARIIAGATDAPFEAL 67
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 13-245 3.31e-63

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 200.39  E-value: 3.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  13 KMLLEESYVSNTEISTTLYLSFLLGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEGITFEQIVGEWNYQKQllhl 92
Cdd:COG0714     7 RAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ---- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  93 eaarndsnnvdeiFDDEFFIRRSLLNaflndkdSVLLIDEIDKADEEVESFLLQALGEQEITInDLGTFQLKNDLIVILT 172
Cdd:COG0714    83 -------------TGEFEFRPGPLFA-------NVLLADEINRAPPKTQSALLEAMEERQVTI-PGGTYKLPEPFLVIAT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 173 SN-----SQRSLLDETKDRCLF-LYIPYPTVEREIEIVKSKLPG-------------------------VEDETVSYVVK 221
Cdd:COG0714   142 QNpieqeGTYPLPEAQLDRFLLkLYIGYPDAEEEREILRRHTGRhlaevepvlspeellalqelvrqvhVSEAVLDYIVD 221

                         250       260
                  ....*....|....*....|....*
gi 2536127730 222 LVHQIRNLN-LMKKPSVRGTVDWVR 245
Cdd:COG0714   222 LVRATREHPdLRKGPSPRASIALLR 246
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 39-187 1.14e-15

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 71.94  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  39 PMLIEGPPGVGKTELAKVIAKAFDRD-FFRIQCYEGITFEQIVGEWNYQKQLlhleAARNDSnnvdeifddeffirrSLL 117
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRpVFYVQLTRDTTEEDLFGRRNIDPGG----ASWVDG---------------PLV 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2536127730 118 NAFLNDKdsVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQLK--NDLIVILTSNSQRSLLDE----TKDRC 187
Cdd:pfam07728  62 RAAREGE--IAVLDEINRANPDVLNSLLSLLDERRLLLPDGGELVKAapDGFRLIATMNPLDRGLNElspaLRSRF 135
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 40-174 4.93e-13

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 64.50  E-value: 4.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEGITFEQIVGEwnyqkqllhleaarndsnnvdEIFDD---EFFIRRSL 116
Cdd:pfam07726   2 VLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGT---------------------EVFDQktrEFEFRPGP 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2536127730 117 LnaFLNdkdsVLLIDEIDKADEEVESFLLQALGEQEITInDLGTFQLKNDLIVILTSN 174
Cdd:pfam07726  61 V--FAN----VLLADEINRAPPKTQSALLEAMQERQVTI-DGETHPLPEPFFVLATQN 111
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 36-182 8.25e-12

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 61.92  E-value: 8.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  36 LGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEgiTFEQIVGEwnyqkqllhLEAarndsnNVDEIFDDeffIRRS 115
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSS--LLSKYVGE---------SEK------NLRKIFER---ARRL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536127730 116 llnaflndKDSVLLIDEIDKA------------DEEVESFLLQALGEQEITindlgtfqlkNDLIVILTSNsQRSLLDE 182
Cdd:cd19481    85 --------APCILFIDEIDAIgrkrdssgesgeLRRVLNQLLTELDGVNSR----------SKVLVIAATN-RPDLLDP 144
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 37-187 2.56e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 60.62  E-value: 2.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  37 GKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCyegITFEQIVGEWnyqkqllhleaarndsnnvDEIFDDEFFIRRSL 116
Cdd:cd00009    19 PKNLLLYGPPGTGKTTLARAIANELFRPGAPFLY---LNASDLLEGL-------------------VVAELFGHFLVRLL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2536127730 117 LNAFLNDKDSVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQlkndLIVILTSNSQRSLLDETKDRC 187
Cdd:cd00009    77 FELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNDLRIDRENVR----VIGATNRPLLGDLDRALYDRL 143
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 40-194 5.58e-11

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 59.14  E-value: 5.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEgiTFEQIVGEwnyqkqllhleaarnDSNNVDEIFDDEFFIRRsllna 119
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSE--LVSKYVGE---------------SEKRLRELFEAAKKLAP----- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 120 flndkdSVLLIDEIDK-----------ADEEVESFLLQALGEQEItindlgtfqLKNDLIVILTSNSQRSLLDETKDRC- 187
Cdd:pfam00004  59 ------CVIFIDEIDAlagsrgsggdsESRRVVNQLLTELDGFTS---------SNSKVIVIAATNRPDKLDPALLGRFd 123


                  ....*..
gi 2536127730 188 LFLYIPY 194
Cdd:pfam00004 124 RIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 37-181 8.41e-11

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.92  E-value: 8.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730   37 GKPMLIEGPPGVGKTELAKVIAKAFDRDFFRIqcyegitfEQIVGEWNYQKQLLHLEAARNDSNNVDEIFDDEFFIRRSL 116
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGV--------IYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALAL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2536127730  117 LNAFLNDkdsVLLIDEIDKADEEVESFLLQALGEQEITINdlgtFQLKNDLIVILTSNSQRSLLD 181
Cdd:smart00382  74 ARKLKPD---VLILDEITSLLDAEQEALLLLLEELRLLLL----LKSEKNLTVILTTNDEKDLGP 131
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 36-210 5.27e-10

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 59.54  E-value: 5.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  36 LGKPMLIEGPPGVGKTELAKVIAKAFDRDFFRiqcyegITFEQIVGEWnyqkqllHLEAARndsnNVDEIFDDeffIRRS 115
Cdd:COG0464   190 PPRGLLLYGPPGTGKTLLARALAGELGLPLIE------VDLSDLVSKY-------VGETEK----NLREVFDK---ARGL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 116 llnaflndKDSVLLIDEIDK------------ADEEVeSFLLQALGEqeitindlgtfqLKNDLIVILTSNSQRSL---- 179
Cdd:COG0464   250 --------APCVLFIDEADAlagkrgevgdgvGRRVV-NTLLTEMEE------------LRSDVVVIAATNRPDLLdpal 308

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2536127730 180 ---LDETkdrclfLYIPYPTVEREIEIVKSKLPG 210
Cdd:COG0464   309 lrrFDEI------IFFPLPDAEERLEIFRIHLRK 336
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 44-174 1.12e-07

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 50.64  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  44 GPPGVGKTELAKVIAKAF---DRDFFRIQCYEgitfeqivgewnyqKQLLHlEAARNDSNNVDEIFDDEffiRRSLLNAF 120
Cdd:cd19499    48 GPTGVGKTELAKALAELLfgdEDNLIRIDMSE--------------YMEKH-SVSRLIGAPPGYVGYTE---GGQLTEAV 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2536127730 121 LNDKDSVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQLKNdLIVILTSN 174
Cdd:cd19499   110 RRKPYSVVLLDEIEKAHPDVQNLLLQVLDDGRLTDSHGRTVDFKN-TIIIMTSN 162
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 37-68 2.90e-07

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 49.48  E-value: 2.90e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2536127730  37 GKPMLIEGPPGVGKTELAKVIAKAFDRDFFRI 68
Cdd:cd19500    37 GPILCLVGPPGVGKTSLGKSIARALGRKFVRI 68
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 41-222 3.39e-07

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 50.78  E-value: 3.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  41 LIEGPPGVGKTELAKVIAKAFDRDFFRiqcyegITFEQIVGEWnyqkqllhL-EAARndsnNVDEIFDdefFIRRSllna 119
Cdd:COG1222   116 LLYGPPGTGKTLLAKAVAGELGAPFIR------VRGSELVSKY--------IgEGAR----NVREVFE---LAREK---- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 120 flndKDSVLLIDEID----KADEEVESfllqalGEQEITINDLGT----FQLKNDLIVILTSNSQRSLldetkDRCLF-- 189
Cdd:COG1222   171 ----APSIIFIDEIDaiaaRRTDDGTS------GEVQRTVNQLLAeldgFESRGDVLIIAATNRPDLL-----DPALLrp 235

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2536127730 190 ------LYIPYPTVEREIEIVK---SKLPGVEDETVSYVVKL 222
Cdd:COG1222   236 grfdrvIEVPLPDEEAREEILKihlRDMPLADDVDLDKLAKL 277
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 40-68 1.98e-06

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 48.51  E-value: 1.98e-06
                          10        20
                  ....*....|....*....|....*....
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRDFFRI 68
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVAL 80
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 44-68 2.09e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 48.54  E-value: 2.09e-06
                          10        20
                  ....*....|....*....|....*
gi 2536127730  44 GPPGVGKTELAKVIAKAFDRDFFRI 68
Cdd:PRK13342   43 GPPGTGKTTLARIIAGATDAPFEAL 67
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 44-68 2.98e-06

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 48.47  E-value: 2.98e-06
                          10        20
                  ....*....|....*....|....*
gi 2536127730  44 GPPGVGKTELAKVIAKAFDRDFFRI 68
Cdd:COG0466   359 GPPGVGKTSLGKSIARALGRKFVRI 383
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 41-174 7.91e-06

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 45.26  E-value: 7.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  41 LIEGPPGVGKTELAKVIAKA---FDRDFFRIQCYEgITFEQIVgewnyqkqlLHLEAARNDSNNVDEifddeffiRRSLL 117
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELlfgDERALIRIDMSE-YMEEHSV---------SRLIGAPPGYVGYEE--------GGQLT 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2536127730 118 NAFLNDKDSVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQLKNDLIvILTSN 174
Cdd:pfam07724  69 EAVRRKPYSIVLIDEIEKAHPGVQNDLLQILEGGTLTDKQGRTVDFKNTLF-IMTGN 124
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
40-208 1.81e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 44.87  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRDFFRIQcyegitFEQIVGEwnyqkqllHL-EAARndsnNVDEIFDdefFIRRslln 118
Cdd:COG1223    38 ILFYGPPGTGKTMLAEALAGELKLPLLTVR------LDSLIGS--------YLgETAR----NLRKLFD---FARR---- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 119 aflndKDSVLLIDEID-----KADE-------EVESFLLQALGEqeitindlgtfqLKNDLIVILTSNsQRSLLDET-KD 185
Cdd:COG1223    93 -----APCVIFFDEFDaiakdRGDQndvgevkRVVNALLQELDG------------LPSGSVVIAATN-HPELLDSAlWR 154

                         170       180
                  ....*....|....*....|....
gi 2536127730 186 RC-LFLYIPYPTVEREIEIVKSKL 208
Cdd:COG1223   155 RFdEVIEFPLPDKEERKEILELNL 178
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 40-152 2.13e-05

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRD---FFRIQCYEGIT-------------FEQIVGEWNYQKQLLHLEAARNDSNNVD 103
Cdd:pfam13191  27 VLLTGEAGTGKTTLLRELLRALERDggyFLRGKCDENLPyspllealtreglLRQLLDELESSLLEAWRAALLEALAPVP 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2536127730 104 EIFDDEFFIRRSLLNAFL-----NDKDSVLLIDEIDKADEEVESFLLQALGEQE 152
Cdd:pfam13191 107 ELPGDLAERLLDLLLRLLdllarGERPLVLVLDDLQWADEASLQLLAALLRLLE 160
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 38-134 2.35e-05

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 43.81  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  38 KPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEgiTFEQIVGEwnyqkqllhLEAArndsnnVDEIFddeffiRRSLL 117
Cdd:cd19511    28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPE--LFSKYVGE---------SERA------VREIF------QKARQ 84

                          90
                  ....*....|....*..
gi 2536127730 118 NAflndkDSVLLIDEID 134
Cdd:cd19511    85 AA-----PCIIFFDEID 96
PRK10865 PRK10865
ATP-dependent chaperone ClpB;
41-182 5.88e-05

ATP-dependent chaperone ClpB;


Pssm-ID: 182791 [Multi-domain]  Cd Length: 857  Bit Score: 44.45  E-value: 5.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  41 LIEGPPGVGKTELAKVIAK-AFDRD--FFRIQCYEGI---TFEQIVGE----WNYQKQLLHLEAARndsnnvdeifddef 110
Cdd:PRK10865  602 LFLGPTGVGKTELCKALANfMFDSDdaMVRIDMSEFMekhSVSRLVGAppgyVGYEEGGYLTEAVR-------------- 667

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536127730 111 fiRRSLlnaflndkdSVLLIDEIDKADEEVESFLLQALGEQEITINDLGTFQLKNDlIVILTSNSQRSLLDE 182
Cdd:PRK10865  668 --RRPY---------SVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNT-VVIMTSNLGSDLIQE 727
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
36-198 9.22e-05

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 43.04  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  36 LGKPMLIEGPPGVGKTELAKVIAkafdRDFFRIQCYEGITFEQIVGEWNYQKQ---LLHLEA-ARNDSNNVDEIFD-DEF 110
Cdd:COG0470    17 LPHALLLHGPPGIGKTTLALALA----RDLLCENPEGGKACGQCHSRLMAAGNhpdLLELNPeEKSDQIGIDQIRElGEF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730 111 FIRRSLLNAFlndkdSVLLIDEIDKADEEVESFLLQALGEqeitindlgtfqLKNDLIVILTSNSQRSLLDETKDRCLFL 190
Cdd:COG0470    93 LSLTPLEGGR-----KVVIIDEADAMNEAAANALLKTLEE------------PPKNTPFILIANDPSRLLPTIRSRCQVI 155


                  ....*...
gi 2536127730 191 YIPYPTVE 198
Cdd:COG0470   156 RFRPPSEE 163
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 38-142 2.29e-04

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 40.74  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  38 KPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQCYEgitfeqIVGEWnyqkqllhleaARNDSNNVDEIFDDEffirrsll 117
Cdd:cd19503    35 RGVLLHGPPGTGKTLLARAVANEAGANFLSISGPS------IVSKY-----------LGESEKNLREIFEEA-------- 89

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2536127730 118 nafLNDKDSVLLIDEID-------KADEEVES 142
Cdd:cd19503    90 ---RSHAPSIIFIDEIDalapkreEDQREVER 118
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 38-174 6.19e-04

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 39.52  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  38 KPMLIEGPPGVGKTELAKVIAKAFDRDFFRIQcyeGITF-EQIVGewnyqkqllhLEAARndsnnVDEIFddeffiRRSL 116
Cdd:cd19501    38 KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSIS---GSDFvEMFVG----------VGASR-----VRDLF------EQAK 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536127730 117 LNAflndkDSVLLIDEIDKADEEVESFLLQALGEQEITINDLGT----FQLKNDLIVILTSN 174
Cdd:cd19501    94 KNA-----PCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVemdgFESNTGVIVIAATN 150
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 31-137 1.31e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 40.14  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  31 YLSFLLGKPMLI-EGPPGVGKTELAKVIAKAF---DRDFFRIqcyegITFEQivgEWNYQKQLLHLeaarndsnnVDEIF 106
Cdd:COG1401   214 FLAALKTKKNVIlAGPPGTGKTYLARRLAEALggeDNGRIEF-----VQFHP---SWSYEDFLLGY---------RPSLD 276

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2536127730 107 DDEFFIRRSLLNAFLN------DKDSVLLIDEIDKAD 137
Cdd:COG1401   277 EGKYEPTPGIFLRFCLkaeknpDKPYVLIIDEINRAN 313
ftsH CHL00176
cell division protein; Validated
 38-174 1.89e-03

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 39.65  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  38 KPMLIEGPPGVGKTELAKVIAKAFDRDFFRIqcyEGITF-EQIVGewnyqkqllhLEAARndsnnVDEIFDDEffirrsl 116
Cdd:CHL00176  217 KGVLLVGPPGTGKTLLAKAIAGEAEVPFFSI---SGSEFvEMFVG----------VGAAR-----VRDLFKKA------- 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536127730 117 lnafLNDKDSVLLIDEIDKADEEVESFLLQALGEQEITINDLGT----FQLKNDLIVILTSN 174
Cdd:CHL00176  272 ----KENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTemdgFKGNKGVIVIAATN 329
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
41-77 2.13e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 39.02  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2536127730  41 LIEGPPGVGKTELAKVIAKAfdrdffrIQCYEGITFE 77
Cdd:COG2812    36 LFTGPRGVGKTTLARILAKA-------LNCENGPTGE 65
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 38-142 5.07e-03

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 36.95  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  38 KPMLIEGPPGVGKTELAKVIAKAFDRDFFRiqcyegITFEQIVGEWnyqkqllhleaarndsnnvdeIFDDEFFIRRSLL 117
Cdd:cd19509    33 RGILLYGPPGTGKTLLARAVASESGSTFFS------ISASSLVSKW---------------------VGESEKIVRALFA 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 2536127730 118 NAFLNdKDSVLLIDEID-----KADEEVES 142
Cdd:cd19509    86 LAREL-QPSIIFIDEIDsllseRGSGEHEA 114
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 33-69 5.89e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 36.63  E-value: 5.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2536127730  33 SFLLGKP--MLIEGPPGVGKTELAKVIAKAFDRDFFRIQ 69
Cdd:cd19520    29 SRLLQPPkgVLLYGPPGCGKTMLAKATAKEAGARFINLQ 67
AAA_22 pfam13401
AAA domain;
40-145 7.62e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 35.78  E-value: 7.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAF---DRDFFRIQCYEGITFEQIvgewnYQKQLLHLEAARNDSNNVDEIFDdefFIRRSL 116
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLpevRDSVVFVDLPSGTSPKDL-----LRALLRALGLPLSGRLSKEELLA---ALQQLL 79

                          90       100
                  ....*....|....*....|....*....
gi 2536127730 117 LNAFLndkDSVLLIDEIDKADEEVESFLL 145
Cdd:pfam13401  80 LALAV---AVVLIIDEAQHLSLEALEELR 105
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 40-69 8.19e-03

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 36.34  E-value: 8.19e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2536127730  40 MLIEGPPGVGKTELAKVIAKAFDRDFFRIQ 69
Cdd:cd19527    29 ILLYGPPGTGKTLLAKAIATECSLNFLSVK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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