|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-470 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 768.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIPN 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 161 EVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDGIMVA 240
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 241 RGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKE 320
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 321 AVKVMNNIAITTENSFDFQNSIKSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTY 400
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTP 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 401 SEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTV 470
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-583 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 759.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEV--ISKTDKEIKCLVKNNGVIKSNKGVNI 158
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 159 PNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNN-SDIKIISKIENQEGVENIDKIIEASDGI 237
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 238 MVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKY 317
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 318 PKEAVKVMNNIAITTENSFDFQN--SIKSKNRQDIlntMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDI 395
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDilSKRPEFTTTI---TNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 396 IAVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTVGKILI 475
Cdd:PRK06354 404 LAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVA 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 476 KGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAEN 555
Cdd:PRK06354 484 KGQGIGRKSVSGKARVAKTAAEV-AKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKN 562
|
570 580
....*....|....*....|....*...
gi 2536718055 556 ATNMIKDEQLVTIDTVGGLVYDGDVKVL 583
Cdd:PRK06354 563 ATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-470 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 604.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 -EVILKAGDFYTFTIDE--VLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTD-KEIKCLVKNNGVIKSNKGV 156
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 157 NIPNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDG 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 237 IMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGK 316
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 317 YPKEAVKVMNNIAITTENSFDFQNSIKSKNRQ--DILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVD 394
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLtpRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 395 IIAVTYSEKVRRKLQIFWGVTSLISKK-----SEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGvAGTTNLIKVHT 469
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILT 479
|
.
gi 2536718055 470 V 470
Cdd:cd00288 480 V 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-467 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 596.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDE 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 82 VILKAGDFYTFTID--EVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIP 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 160 NEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDD-NNSDIKIISKIENQEGVENIDKIIEASDGIM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEkGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 239 VARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 319 KEAVKVMNNIAITTENSFDFQNSIKSKNRQDI--LNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDII 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPkpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536718055 397 AVTYSEKVRRKLQIFWGVTS-LISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKV 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPfLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-340 |
7.92e-168 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 480.71 E-value: 7.92e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKF--S 78
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkdG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 79 IDEVILKAGDFYTFTIDEVL---GNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISK-TDKEIKCLVKNNGVIKSNK 154
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 155 GVNIPNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEAS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 235 DGIMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAA 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|....*.
gi 2536718055 315 GKYPKEAVKVMNNIAITTENSFDFQN 340
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRN 346
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
471-569 |
8.05e-25 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 107.61 E-value: 8.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 471 GKILIKGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTI 550
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIADEAEL-ARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90
....*....|....*....
gi 2536718055 551 IGAENATNMIKDEQLVTID 569
Cdd:COG0574 430 VGCGDATRVLKDGDEITVD 448
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
471-580 |
7.04e-24 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 106.37 E-value: 7.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 471 GKILIKGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTI 550
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISEM-DKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100 110
....*....|....*....|....*....|....*
gi 2536718055 551 IGAENATNMIKDEQLVTI-----DTvgGLVYDGDV 580
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVscaegDT--GYVYEGLL 464
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
501-569 |
9.48e-23 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 92.09 E-value: 9.48e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536718055 501 KFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQLVTID 569
Cdd:pfam00391 1 KLPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVD 69
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-470 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 768.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIPN 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 161 EVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDGIMVA 240
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 241 RGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKE 320
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 321 AVKVMNNIAITTENSFDFQNSIKSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTY 400
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTP 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 401 SEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTV 470
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-583 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 759.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEV--ISKTDKEIKCLVKNNGVIKSNKGVNI 158
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 159 PNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNN-SDIKIISKIENQEGVENIDKIIEASDGI 237
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 238 MVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKY 317
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 318 PKEAVKVMNNIAITTENSFDFQN--SIKSKNRQDIlntMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDI 395
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDilSKRPEFTTTI---TNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 396 IAVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTVGKILI 475
Cdd:PRK06354 404 LAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVA 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 476 KGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAEN 555
Cdd:PRK06354 484 KGQGIGRKSVSGKARVAKTAAEV-AKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKN 562
|
570 580
....*....|....*....|....*...
gi 2536718055 556 ATNMIKDEQLVTIDTVGGLVYDGDVKVL 583
Cdd:PRK06354 563 ATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-460 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 621.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTF-TIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIP 159
Cdd:PRK05826 83 KITLKTGDKFTLdTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 160 NEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNS-DIKIISKIENQEGVENIDKIIEASDGIM 238
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 239 VARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYP 318
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 319 KEAVKVMNNIAITTENSFDFQNSIKSKNRQdiLNTMN-SISLSTKEIAENL-RAKAIICATASGITPISISKFRPFVDII 396
Cdd:PRK05826 323 VEAVEAMARICKGAEKEFSINLSKHRLDRQ--FDRIDeAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIF 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2536718055 397 AVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAG 460
Cdd:PRK05826 401 AVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-470 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 604.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSID 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 -EVILKAGDFYTFTIDE--VLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTD-KEIKCLVKNNGVIKSNKGV 156
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 157 NIPNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDG 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 237 IMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGK 316
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 317 YPKEAVKVMNNIAITTENSFDFQNSIKSKNRQ--DILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVD 394
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLtpRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 395 IIAVTYSEKVRRKLQIFWGVTSLISKK-----SEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGvAGTTNLIKVHT 469
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRILT 479
|
.
gi 2536718055 470 V 470
Cdd:cd00288 480 V 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-467 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 596.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDE 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 82 VILKAGDFYTFTID--EVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIP 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 160 NEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDD-NNSDIKIISKIENQEGVENIDKIIEASDGIM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEkGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 239 VARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 319 KEAVKVMNNIAITTENSFDFQNSIKSKNRQDI--LNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDII 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPkpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536718055 397 AVTYSEKVRRKLQIFWGVTS-LISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKV 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPfLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-470 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 549.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSI- 79
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 80 DEVILKAGDFYTFTID-EVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNI 158
Cdd:PRK09206 81 NDVSLKAGQTFTFTTDkSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 159 PNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNN-SDIKIISKIENQEGVENIDKIIEASDGI 237
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgENIQIISKIENQEGLNNFDEILEASDGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 238 MVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKY 317
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 318 PKEAVKVMNNIAITTENSFDFQnsIKSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIA 397
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNSR--LESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2536718055 398 VTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVgVAGTTNLIKVHTV 470
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-471 |
3.96e-176 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 506.77 E-value: 3.96e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDE 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 82 VILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIPNE 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 162 VINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNnsdIKIISKIENQEGVENIDKIIEASDGIMVAR 241
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEASDAIMVAR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 242 GDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKEA 321
Cdd:PRK06247 242 GDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 322 VKVMNNIAITTENSFDFQNSIKSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTYS 401
Cdd:PRK06247 322 VRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTPN 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 402 EKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTVG 471
Cdd:PRK06247 402 PETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIG 471
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-340 |
7.92e-168 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 480.71 E-value: 7.92e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKF--S 78
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkdG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 79 IDEVILKAGDFYTFTIDEVL---GNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISK-TDKEIKCLVKNNGVIKSNK 154
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 155 GVNIPNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEAS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 235 DGIMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAA 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|....*.
gi 2536718055 315 GKYPKEAVKVMNNIAITTENSFDFQN 340
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRN 346
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-470 |
4.74e-162 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 472.16 E-value: 4.74e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDE 81
Cdd:PLN02461 21 PKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 82 VI-LKAGDFYTFTID-EVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISkTDKE---IKCLVKNNGVIKSNKGV 156
Cdd:PLN02461 101 PVqLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLS-CDVEagtVRCRCENSAMLGERKNV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 157 NIPNEVINLPSITEKDKSDIL-FGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASD 235
Cdd:PLN02461 180 NLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 236 GIMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAG 315
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 316 KYPKEAVKVMNNIAITTENSFDFQNSIKSKNRQDIL--NTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFV 393
Cdd:PLN02461 340 AYPELAVKTMARICREAEASLDYGALFKEIMRSAPLpmSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPAV 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 394 DIIAVTYSEKVR-------------RKLQIFWGVTSLISKKS------EHTDEVIERSISATLNANYISDGDTVVLTAGI 454
Cdd:PLN02461 420 PILSVVVPEITTdsfdwscsdeapaRHSLIYRGLIPVLAEGSakatdsESTEEILEAAIEHAKKKGLCKPGDSVVALHRI 499
|
490
....*....|....*.
gi 2536718055 455 pvgvaGTTNLIKVHTV 470
Cdd:PLN02461 500 -----GGASVIKILTV 510
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-470 |
8.62e-154 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 451.14 E-value: 8.62e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREEL-DLPIAIMLDTKGPEIRLGKF-SI 79
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLkNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 80 DEVILKAGDFYTFTID-EVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNI 158
Cdd:PTZ00066 118 KPITLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 159 PNEVINLPSITEKDKSDIL-FGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDGI 237
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 238 MVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKY 317
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 318 PKEAVKVMNNIAITTENSFD----FQNSIKSKNRQdiLNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFV 393
Cdd:PTZ00066 358 PVEAVNIMAKICFEAETCIDyrvlYHAIHLAVPTP--VSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSC 435
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2536718055 394 DIIAVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTV 470
Cdd:PTZ00066 436 TILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVKI 512
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
263-583 |
1.47e-143 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 417.76 E-value: 1.47e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 263 KCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKEAVKVMNNIAITTENSFDFQNSI 342
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 343 KSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTYSEKVRRKLQIFWGVTSLISKKS 422
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 423 EHTDEVIERSISATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVHTVGKILIKGFGIGKDSVTGKACLINNEDDLKNKF 502
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 503 KDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQLVTIDTVGGLVYDGDVKV 582
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
.
gi 2536718055 583 L 583
Cdd:COG3848 321 L 321
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-470 |
9.17e-133 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 399.69 E-value: 9.17e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 2 KKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKK-AREELDLPIAIMLDTKGPEIRLGKFSiD 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLP-Q 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKAGDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIPN 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 161 EVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDGIMVA 240
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVA 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 241 RGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKE 320
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 321 AVKVMNNIAITTENSFDFqNSIKSKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTY 400
Cdd:PLN02623 429 AVKVMHTVALRTEATLPE-GTTPPNLGQAFKNHMSEMFAFHATMMANTLGTSIIVFTRTGFMAILLSHYRPSGTIFAFTN 507
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2536718055 401 SEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVL--TAGIPVGVAGTTNLIKVHTV 470
Cdd:PLN02623 508 EKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALvqSGRQPIWRSESTHHIQVRKV 579
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-450 |
3.79e-123 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 370.54 E-value: 3.79e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 28 MNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDEVILKAGDFYTFTIDEVL---GNQEIC 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFadkGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 105 SVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKE-IKCLVKNNGVIKSNKGVNIPNEVINLPSITEKDKSDILFGIQND 183
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 184 LDFIAASFVRKPEDVYEIRKILDDNNSDIKIISKIENQEGVENIDKIIEASDGIMVARGDLGVEIKAEFIPKIQKEIIRK 263
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 264 CNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKEAVKVMNNIAITTE---NSFDFQN 340
Cdd:PTZ00300 241 CNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQsavNEYVFFN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 341 SIKsKNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTYSEKVRRKLQIFWGVTSLISK 420
Cdd:PTZ00300 321 SIK-KLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFD 399
|
410 420 430
....*....|....*....|....*....|....*
gi 2536718055 421 -----KSEHTDEVIERSISATLNANYISDGDTVVL 450
Cdd:PTZ00300 400 aerlgHDEGKEQRVAMGVGFAKSKGYVQSGDLMVV 434
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-470 |
3.38e-107 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 331.32 E-value: 3.38e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 1 MKKTKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSiD 80
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLG-G 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 81 EVILKA--GDFYTFTIDEVLGNQEIC--SVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVI--KSN- 153
Cdd:PLN02762 103 ASSAKAedGEEWTFTVRKFDGSRPEFtiQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLlpRANl 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 154 ----KGVNIPNEVINLPSITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRKILDDN--NSDIKIISKIENQEGVENI 227
Cdd:PLN02762 183 tfwrDGSLVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLDSLKNL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 228 DKIIEASDGIMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIM 307
Cdd:PLN02762 263 EEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALM 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 308 LSGETAAGKYPKEAVKVMNNIAITTENSFDFQNSIKSKNRQDILNTMN-----SISLSTKEIAENLRAKAIICATASGIT 382
Cdd:PLN02762 343 LSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELPQLSSSLSdriseEICNSAAKMANNLGVDAIFVYTKHGHM 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 383 PISISKFRPFVDIIAVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSISATLNANYISDGDTVVLTAGIPvgVAGTT 462
Cdd:PLN02762 423 ASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAVSDLT--PSSML 500
|
....*...
gi 2536718055 463 NLIKVHTV 470
Cdd:PLN02762 501 QSIQVRNV 508
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-329 |
8.47e-105 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 319.97 E-value: 8.47e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 7 ICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKkareELDLPIAIMLDTKGPEIRLGKFSIDEVILKA 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVK----SLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 87 GDFYTFTIDEVLGNQEICSVSYKLLPNDVKVGGTILVDDGLVEMEVISKTDKEIKCLVKNNGVIKSNKGVNIPNEVINLP 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 167 SITEKDKSDILFGIQNDLDFIAASFVRKPEDVYEIRK-ILDDNNSDIKIISKIENQEGVENIDKIIEASDGIMVARGDLG 245
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDfIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 246 VEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGETAAGKYPKEAVKVM 325
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTL 321
|
....
gi 2536718055 326 NNIA 329
Cdd:PRK06739 322 RLVS 325
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-398 |
4.04e-99 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 311.22 E-value: 4.04e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 4 TKIICTIGPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDEVI 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 84 LKAGDFYTFTIDE-VLGNQEICSVSYKLLPNDVKVGGTILVDDGL--------VEMEVISKTDKEIKCLVKNNGVIKSNK 154
Cdd:PLN02765 110 LKAGNTVTLTPDQsKEASSEVLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKGDDVVCTVKNSATLAGSL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 155 -GVNIPNEVINLPSITEKDKSDI-LFGIQNDLDFIAASFVRKPEDVYEIRKILDDNN-SDIKIISKIENQEGVENIDKII 231
Cdd:PLN02765 190 fTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFDEIL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 232 EASDGIMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITaTQMLDSMIRNPRPTRAEVTDVANAIIDGSDCIMLSGE 311
Cdd:PLN02765 270 QEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAE 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 312 TAAGKYPKEAVKVMNNIAITTENSFDFQNSIKS--KNRQDILNTMNSISLSTKEIAENLRAKAIICATASGITPISISKF 389
Cdd:PLN02765 349 TLRGLYPVETISTVGRICAEAEKVFNQDLYFKKtvKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLIAKY 428
|
....*....
gi 2536718055 390 RPFVDIIAV 398
Cdd:PLN02765 429 RPTMPVLSV 437
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-328 |
6.72e-51 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 182.52 E-value: 6.72e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 4 TKIICTI-GPASDSVENLKELMLSGMNVCRLNFSHGSKEEHQVRIDNIKKAREELDLPIAIMLDTKGPEIRLGKFSIDEV 82
Cdd:PRK08187 135 TRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPLG 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 83 I--LKAGDFYTFT-------IDEVLGnQEICSVSyKLLPNdVKVGGTILVDDGLVEMEVISKTDKEIKCLV---KNNGV- 149
Cdd:PRK08187 215 KtrLYTGDRLALVaqgpprrIDEEHF-QVTCTLP-EILAR-LAVGARVWIDDGKLGARVERVGPGGALLEVthaRPKGLk 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 150 IKSNKGVNIPNEVINLPSITEKDKSDilfgiqndLDFIAA-------SFVRKPEDVY----EIRKILDDNNSDIKIISKI 218
Cdd:PRK08187 292 LKPEKGLNFPDTALDLPALTEKDRAD--------LDFVARhadlvgySFVQSPGDVEalqaALAARRPDDWRKLGLVLKI 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 219 ENQEGVENIDKIIEASDG-----IMVARGDLGVEIKAEFIPKIQKEIIRKCNLVGKPVITATQMLDSMIRNPRPTRAEVT 293
Cdd:PRK08187 364 ETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMT 443
|
330 340 350
....*....|....*....|....*....|....*
gi 2536718055 294 DVANAiiDGSDCIMLSgetaAGKYPKEAVKVMNNI 328
Cdd:PRK08187 444 DAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
355-468 |
3.78e-41 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 144.55 E-value: 3.78e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 355 NSISLSTKEIAENLRAKAIICATASGITPISISKFRPFVDIIAVTYSEKVRRKLQIFWGVTSLISKKSEHTDEVIERSIS 434
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|....
gi 2536718055 435 ATLNANYISDGDTVVLTAGIPVGVAGTTNLIKVH 468
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
113-328 |
1.98e-39 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 152.41 E-value: 1.98e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 113 NDVKVGGTILVDDGLVEMEVISKTDKEIKCLV---KNNGV-IKSNKGVNIPNEVINLPSITEKDKSDILFGIQNdLDFIA 188
Cdd:PRK14725 371 RAARVGERVWFDDGKIGAVVVKVEADEVELRIthaRPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 189 ASFVRKPEDVYEIRKILDD-NNSDIKIISKIENQEGVENIDKII-EA----SDGIMVARGDLGVEIKAEFIPKIQKEIIR 262
Cdd:PRK14725 450 LSFVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRILlEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILW 529
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2536718055 263 KCNLVGKPVITATQMLDSMIRNPRPTRAEVTDVANAIidGSDCIMLSgetaAGKYPKEAVKVMNNI 328
Cdd:PRK14725 530 LCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDI 589
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
471-569 |
8.05e-25 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 107.61 E-value: 8.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 471 GKILIKGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTI 550
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIADEAEL-ARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90
....*....|....*....
gi 2536718055 551 IGAENATNMIKDEQLVTID 569
Cdd:COG0574 430 VGCGDATRVLKDGDEITVD 448
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
471-580 |
7.04e-24 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 106.37 E-value: 7.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 471 GKILIKGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTI 550
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISEM-DKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100 110
....*....|....*....|....*....|....*
gi 2536718055 551 IGAENATNMIKDEQLVTI-----DTvgGLVYDGDV 580
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVscaegDT--GYVYEGLL 464
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
501-569 |
9.48e-23 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 92.09 E-value: 9.48e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536718055 501 KFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQLVTID 569
Cdd:pfam00391 1 KLPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVD 69
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
485-569 |
2.81e-13 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 73.00 E-value: 2.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 485 VTGKACLINNEDDlkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQ 564
Cdd:PRK06241 778 VEGRARVILNPED--ADLEKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENATKLIKDGQ 855
|
....*
gi 2536718055 565 LVTID 569
Cdd:PRK06241 856 RIRVD 860
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
475-575 |
3.38e-11 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 65.83 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 475 IKGFGIGKDSVTGKACLINNEDDLkNKFKDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAE 554
Cdd:PRK08296 500 LKGFAASPGVVEGPARVIRSADEL-SEVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTG 578
|
90 100
....*....|....*....|.
gi 2536718055 555 NATNMIKDEQLVTIDTVGGLV 575
Cdd:PRK08296 579 NATKRIKTGQRLRVDGTKGVV 599
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
522-576 |
1.95e-09 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 60.09 E-value: 1.95e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2536718055 522 DRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQLVTIDTVGGLVY 576
Cdd:COG1080 173 SRVAGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVI 227
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
475-583 |
4.37e-08 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 56.20 E-value: 4.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536718055 475 IKGFGIGKDSVTGKACLINNE--DDLKnkfkDGDIIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIG 552
Cdd:PRK05865 736 LRGVGVCGGRVRGRVRIVRPEtiDDLQ----PGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVD 811
|
90 100 110
....*....|....*....|....*....|.
gi 2536718055 553 AENATNMIKDEQLVTIDTVgglvyDGDVKVL 583
Cdd:PRK05865 812 AQGATRFLPPGALVEVDGA-----TGEIHVV 837
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
507-582 |
4.71e-07 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 52.44 E-value: 4.71e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2536718055 507 IIVSKFTDREYVEFIDRASGIIVETGGLTSHAAIIALHFNIPTIIGAENATNMIKDEQLVTIDTVGGLVYDGDVKV 582
Cdd:PRK05878 383 ILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAVVGCGAGVAAALAGKEITVDGYEGEVRQGVLAL 458
|
|
| |
