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Conserved domains on  [gi|2537515233|ref|WP_294087172|]
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PTS glucose transporter subunit IIA [Pseudoalteromonas sp.]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagE super family cl43637
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
3-146 2.22e-11

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2190:

Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 57.83  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQV---KNAgkeYILQAKNGLKVLLnlsfssvee 79
Cdd:COG2190     8 IYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVfptKHA---IGLTSDDGLEVLI--------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233  80 HINhTNIAKLNGS----------KISQGERLAYFDL-------RELSSPMLgtlcVLNSQHLGPL-YYSLSQVIAGvDTL 141
Cdd:COG2190    76 HIG-IDTVKLNGEgftvlvkegdKVKAGDPLIEFDLdaikaagYSLITPVV----VTNSDEYKSVeLTKSGQVKAG-DPL 149


                  ....*
gi 2537515233 142 LTVTK 146
Cdd:COG2190   150 LTVKL 154
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
3-146 2.22e-11

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 57.83  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQV---KNAgkeYILQAKNGLKVLLnlsfssvee 79
Cdd:COG2190     8 IYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVfptKHA---IGLTSDDGLEVLI--------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233  80 HINhTNIAKLNGS----------KISQGERLAYFDL-------RELSSPMLgtlcVLNSQHLGPL-YYSLSQVIAGvDTL 141
Cdd:COG2190    76 HIG-IDTVKLNGEgftvlvkegdKVKAGDPLIEFDLdaikaagYSLITPVV----VTNSDEYKSVeLTKSGQVKAG-DPL 149


                  ....*
gi 2537515233 142 LTVTK 146
Cdd:COG2190   150 LTVKL 154
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 3-110 9.41e-11

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 55.72  E-value: 9.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVEEHIN 82
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100
                  ....*....|....*....|....*...
gi 2537515233  83 HTNIAKLNGSKISQGERLAYFDLRELSS 110
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKK 108
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
1-108 8.97e-10

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 52.77  E-value: 8.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   1 MAIKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQV---KNAgkeYILQAKNGLKVLLnlsfssv 77
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVfptKHA---IGITTDDGVEVLI------- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2537515233  78 eehinHTNI--AKLNG----------SKISQGERLAYFDLREL 108
Cdd:pfam00358  71 -----HIGIdtVKLKGegfeslvkegDKVKAGDLLLEFDLEAI 108
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-105 4.63e-08

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 48.44  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVeehin 82
Cdd:cd00210     1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTV----- 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2537515233  83 htniaKLNG----------SKISQGERLAYFDL 105
Cdd:cd00210    76 -----KLNGegftshveegQRVKQGDKLLEFDL 103
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 5-137 9.78e-06

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 44.09  E-value: 9.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   5 SPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVEehINHT 84
Cdd:PRK10255  503 SPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVA--LEGK 580

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2537515233  85 NIAKL--NGSKISQGERLAYFDLRELSS---PMLGTLCVLNSQHLGPLYYSLS-QVIAG 137
Cdd:PRK10255  581 GFKRLveEGAQVSAGQPILEMDLDYLNAnarSMISPVVCSNIDDFSGLIIKAQgHVVAG 639
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
3-146 2.22e-11

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 57.83  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQV---KNAgkeYILQAKNGLKVLLnlsfssvee 79
Cdd:COG2190     8 IYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVfptKHA---IGLTSDDGLEVLI--------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233  80 HINhTNIAKLNGS----------KISQGERLAYFDL-------RELSSPMLgtlcVLNSQHLGPL-YYSLSQVIAGvDTL 141
Cdd:COG2190    76 HIG-IDTVKLNGEgftvlvkegdKVKAGDPLIEFDLdaikaagYSLITPVV----VTNSDEYKSVeLTKSGQVKAG-DPL 149


                  ....*
gi 2537515233 142 LTVTK 146
Cdd:COG2190   150 LTVKL 154
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 3-110 9.41e-11

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 55.72  E-value: 9.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVEEHIN 82
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100
                  ....*....|....*....|....*...
gi 2537515233  83 HTNIAKLNGSKISQGERLAYFDLRELSS 110
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKK 108
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
1-108 8.97e-10

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 52.77  E-value: 8.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   1 MAIKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQV---KNAgkeYILQAKNGLKVLLnlsfssv 77
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVfptKHA---IGITTDDGVEVLI------- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2537515233  78 eehinHTNI--AKLNG----------SKISQGERLAYFDLREL 108
Cdd:pfam00358  71 -----HIGIdtVKLKGegfeslvkegDKVKAGDLLLEFDLEAI 108
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-105 4.63e-08

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 48.44  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVeehin 82
Cdd:cd00210     1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTV----- 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2537515233  83 htniaKLNG----------SKISQGERLAYFDL 105
Cdd:cd00210    76 -----KLNGegftshveegQRVKQGDKLLEFDL 103
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 5-137 9.78e-06

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 44.09  E-value: 9.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   5 SPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVEehINHT 84
Cdd:PRK10255  503 SPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVA--LEGK 580

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2537515233  85 NIAKL--NGSKISQGERLAYFDLRELSS---PMLGTLCVLNSQHLGPLYYSLS-QVIAG 137
Cdd:PRK10255  581 GFKRLveEGAQVSAGQPILEMDLDYLNAnarSMISPVVCSNIDDFSGLIIKAQgHVVAG 639
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 3-146 2.29e-05

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 41.88  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2537515233   3 IKSPFTGRVKSISEHPELFFRFATLGPSISVELTSHNIIAPFDGTLLQVKNAGKEYILQAKNGLKVLLNLSFSSVEEHIN 82
Cdd:PRK09439   23 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2537515233  83 -HTNIAKlNGSKISQGERLAYFD---LRELSSPMLGTLCVLNSQHLGPLYYSLSQVIAGVDTLLTVTK 146
Cdd:PRK09439  103 gFKRIAE-EGQRVKVGDPIIEFDlplLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAGETPVIRVKK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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