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Conserved domains on  [gi|2539247726|ref|WP_295492926|]
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sensor histidine kinase [uncultured Ralstonia sp.]

Protein Classification

sensor histidine kinase( domain architecture ID 11467953)

sensor histidine kinase may be part of a two-component regulatory system and function as a protein kinase that phosphorylates a target protein in response to a signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 294-657 3.23e-93

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 292.86  E-value: 3.23e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 294 RLPEGAQLVRVGDRINATRYLLVSRELIEPDWELMYLTPVDPVMSAARSATVAAAFAFAFACLLLFYWRQRRLRLMEMLR 373
Cdd:COG4191     3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 374 SRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRT 453
Cdd:COG4191    83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 454 FSDNTRILLERGQHGA-ATDNLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWR 532
Cdd:COG4191   163 NAELLRRRLEDEPDPEeLREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 533 VPEAEALVRADELKLEQVLINLIGNALDAIganDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEP 612
Cdd:COG4191   243 LPPDLPPVLGDPGQLEQVLLNLLINAIDAM---EEGEGGRITISTRREGD------YVVISVRDNGPGIPPEVLERIFEP 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2539247726 613 FFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:COG4191   314 FFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 72-270 1.86e-13

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 70.44  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  72 LSQAQQAAGGRVDRYAANLKSTLDRYEYLPALIALHPFIHDLLANPTPENVARANRYLlevNDRAHATATYVIAPSGQAL 151
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLL---RSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 152 AASNYnqPDSFVGAEYRFRPYFQQAAAG-----HVGRFYGIGITREEPGYYISQPVMQD-GRVIGVTVVKLNLEWFGR-- 223
Cdd:pfam02743  81 ASSDE--SPSYPGLDVSERPWYKEALKGgggiiWVFSSPYPSSESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQEll 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2539247726 224 --ASHDASEPVMVADEHGVIFLSSVPAWQYRTVEPITPELNAHLEATRQ 270
Cdd:pfam02743 159 sqIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSG 207
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 294-657 3.23e-93

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 292.86  E-value: 3.23e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 294 RLPEGAQLVRVGDRINATRYLLVSRELIEPDWELMYLTPVDPVMSAARSATVAAAFAFAFACLLLFYWRQRRLRLMEMLR 373
Cdd:COG4191     3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 374 SRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRT 453
Cdd:COG4191    83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 454 FSDNTRILLERGQHGA-ATDNLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWR 532
Cdd:COG4191   163 NAELLRRRLEDEPDPEeLREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 533 VPEAEALVRADELKLEQVLINLIGNALDAIganDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEP 612
Cdd:COG4191   243 LPPDLPPVLGDPGQLEQVLLNLLINAIDAM---EEGEGGRITISTRREGD------YVVISVRDNGPGIPPEVLERIFEP 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2539247726 613 FFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:COG4191   314 FFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
390-662 6.56e-35

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 140.49  E-value: 6.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 390 EDRTADLMATNEQL---QHEIV-------DRTraeaELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFsdnTR 459
Cdd:PRK11360  341 RDRTIELSVSTSLLhntHGEMIgalvifsDLT----ERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY---VQ 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 460 ILLERGQHGAATDNLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEAL 539
Cdd:PRK11360  414 IWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPP 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 540 VRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVG-PAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKE 618
Cdd:PRK11360  494 IWADPELLKQVLLNILINAVQAISAR-----GKIRIRTWqYSDG------QVAVSIEDNGCGIDPELLKKIFDPFFTTKA 562

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2539247726 619 igQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRAEV 662
Cdd:PRK11360  563 --KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 542-657 9.56e-30

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 113.51  E-value: 9.56e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  542 ADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEI-- 619
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEG-----GRITVTLERDGD------HVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsr 69

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2539247726  620 -GQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:smart00387  70 kIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 3.54e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 111.39  E-value: 3.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGanDAARPgRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLG 626
Cdd:cd16976     1 IQQVLMNLLQNALDAMG--KVENP-RIRIAARRLGG------RLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLG 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2539247726 627 LAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16976    72 LSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 542-657 5.68e-27

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 105.53  E-value: 5.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 542 ADELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEGVpsplkqlSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ 621
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKH-----AAKAGEITVTLSEGGEL-------TLTVEDNGIGIPPEDLPRIFEPFSTADKRGG 68

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2539247726 622 -GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:pfam02518  69 gGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 433-657 5.52e-15

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 77.81  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 433 LGQMAAGITHELNQPLAALRTfsdNTRILLERGQHGAA-TDNLQAIADLTERMGKITAQLKLFA----GRSRRKHSDVQV 507
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLG---QTQVALSQPRTGEEyREVLESNLEELERLSRMVSDMLFLAradnGQLALERVRLDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 508 RVALDHSLALLRPrLGD---VRLELhwrvpEAEALVRADELKLEQVLINLIGNALdaigaNDAARPGRIDIDVGPAEGvp 584
Cdd:TIGR01386 318 AAELAKVAEYFEP-LAEergVRIRV-----EGEGLVRGDPQMFRRAISNLLSNAL-----RHTPDGGTITVRIERRSD-- 384

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2539247726 585 splkQLSIAVRDNGPGIPPDTMPHLFEPFF----TTKEIGQGLGLGLAISTSIARDFGGSLSAiNMPDGGAQFTLTL 657
Cdd:TIGR01386 385 ----EVRVSVSNPGPGIPPEHLSRLFDRFYrvdpARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 72-270 1.86e-13

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 70.44  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  72 LSQAQQAAGGRVDRYAANLKSTLDRYEYLPALIALHPFIHDLLANPTPENVARANRYLlevNDRAHATATYVIAPSGQAL 151
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLL---RSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 152 AASNYnqPDSFVGAEYRFRPYFQQAAAG-----HVGRFYGIGITREEPGYYISQPVMQD-GRVIGVTVVKLNLEWFGR-- 223
Cdd:pfam02743  81 ASSDE--SPSYPGLDVSERPWYKEALKGgggiiWVFSSPYPSSESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQEll 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2539247726 224 --ASHDASEPVMVADEHGVIFLSSVPAWQYRTVEPITPELNAHLEATRQ 270
Cdd:pfam02743 159 sqIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSG 207
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 94-218 3.44e-05

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 43.91  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  94 LDRYEYLPALIALHPFIHDLLANPTPENVARANRYlleVNDRAHATATYVIAPSGQALAASNynqPDSFVGAEYRFRPYF 173
Cdd:cd12914     1 LDEADLLLRSLADDLEARGAASADPAALQALLRRL---LARLPEVRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYF 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2539247726 174 QQAAAGHVGRFYG---IGITREEPGYYISQPVM-QDGRVIGVTVVKLNL 218
Cdd:cd12914    75 QAARAGGGGLFISepvISRVTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 294-657 3.23e-93

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 292.86  E-value: 3.23e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 294 RLPEGAQLVRVGDRINATRYLLVSRELIEPDWELMYLTPVDPVMSAARSATVAAAFAFAFACLLLFYWRQRRLRLMEMLR 373
Cdd:COG4191     3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 374 SRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRT 453
Cdd:COG4191    83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 454 FSDNTRILLERGQHGA-ATDNLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWR 532
Cdd:COG4191   163 NAELLRRRLEDEPDPEeLREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 533 VPEAEALVRADELKLEQVLINLIGNALDAIganDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEP 612
Cdd:COG4191   243 LPPDLPPVLGDPGQLEQVLLNLLINAIDAM---EEGEGGRITISTRREGD------YVVISVRDNGPGIPPEVLERIFEP 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2539247726 613 FFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:COG4191   314 FFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 367-661 7.88e-53

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 187.48  E-value: 7.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 367 RLMEMLRSRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQD--ELVQASKLAALGQMAAGITHEL 444
Cdd:COG5000   133 KPLEELLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDitELLRAERLAAWGELARRIAHEI 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 445 NQPLAALRTFSDNTRILLERGQHGAATDNLQAIADL---TERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPR 521
Cdd:COG5000   213 KNPLTPIQLSAERLRRKLADKLEEDREDLERALDTIirqVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPA 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 522 LGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGI 601
Cdd:COG5000   293 LKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEG-----GEIEVSTRREDG------RVRIEVSDNGPGI 361

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 602 PPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRAE 661
Cdd:COG5000   362 PEEVLERIFEPFFTTKP--KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
406-657 1.34e-50

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 179.66  E-value: 1.34e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 406 EIVDRTraeaELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDntrILLERGQHGAATDNLQAIADLTERMG 485
Cdd:COG3852   112 VLRDIT----ERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQ---LLERELPDDELREYTQLIIEEADRLN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 486 KITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDvRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGAn 565
Cdd:COG3852   185 NLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPE- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 566 daarPGRIDIDVGPAEGVPSPLKQ----LSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGGSL 641
Cdd:COG3852   263 ----GGTITIRTRVERQVTLGGLRprlyVRIEVIDNGPGIPEEILDRIFEPFFTTKE--KGTGLGLAIVQKIVEQHGGTI 336

                         250
                  ....*....|....*.
gi 2539247726 642 SAINMPDGGAQFTLTL 657
Cdd:COG3852   337 EVESEPGKGTTFRIYL 352
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
362-660 2.16e-50

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 178.18  E-value: 2.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 362 RQRRLRLMEMLRSRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQDELVQASkLAALGQMAAGIT 441
Cdd:COG0642    40 LLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEA-NEAKSRFLANVS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 442 HELNQPLAALRTFSDntriLLERGQHGAATDNLQAIADLTERMGKITAQL----KLFAGRSRRKHSDVQVRVALDHSLAL 517
Cdd:COG0642   119 HELRTPLTAIRGYLE----LLLEELDEEQREYLETILRSADRLLRLINDLldlsRLEAGKLELEPEPVDLAELLEEVVEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 518 LRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEGvpsplkQLSIAVRDN 597
Cdd:COG0642   195 FRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY-----TPEGGTVTVSVRREGD------RVRISVEDT 263

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2539247726 598 GPGIPPDTMPHLFEPFFTTKE--IGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRA 660
Cdd:COG0642   264 GPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
416-657 8.99e-44

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 156.99  E-value: 8.99e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 416 ELRATQDELVQASKLaaLGQMAAGITHELNQPLAALRTFSDntriLLERGQHGAATD---NLQAIADLTERMGKITAQL- 491
Cdd:COG2205     1 ELEEALEELEELERL--KSEFLANVSHELRTPLTSILGAAE----LLLDEEDLSPEErreLLEIIRESAERLLRLIEDLl 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 492 ---KLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANdaa 568
Cdd:COG2205    75 dlsRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG--- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 569 rpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIG--QGLGLGLAISTSIARDFGGSLSAINM 646
Cdd:COG2205   152 --GTITISARREGD------GVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESE 223

                         250
                  ....*....|.
gi 2539247726 647 PDGGAQFTLTL 657
Cdd:COG2205   224 PGGGTTFTVTL 234
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 400-641 1.33e-43

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 166.40  E-value: 1.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 400 NEQLQHEIVDRTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLERGQHGAATDNLQAIAD 479
Cdd:COG4192   400 TQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEG 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 480 LTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHwrVPEaEALVRADELKLEQVLINLIGNAL 559
Cdd:COG4192   480 LIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLH--IPD-DLMVQGDQVLLEQVLVNLLVNAL 556

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 560 DAIgandaARPGRIDIDvgpaegVPSPLKQLSIAVRDNGPGIPpdTMPHLFEPFFTTKEIgqGLGLGLAISTSIARDFGG 639
Cdd:COG4192   557 DAV-----ATQPQISVD------LLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEV--GLGLGLSICRSIMQQFGG 621


                  ..
gi 2539247726 640 SL 641
Cdd:COG4192   622 DL 623
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
299-657 2.02e-42

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 158.18  E-value: 2.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 299 AQLVRVGDRINATRYLLVSRELIEPDWELMYLTPVDPVMSAARSATVAAAFAFAFACLLLFYWRQRRLRLMEMLRSRRML 378
Cdd:COG5002    47 LLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 379 ETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRatqdelvqasklaalgQMAAGITHELNQPLAALRTFSDnt 458
Cdd:COG5002   127 LLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR----------------EFVANVSHELRTPLTSIRGYLE-- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 459 riLLERGQHG---AATDNLQAIADLTERMGKITAQL----KLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHW 531
Cdd:COG5002   189 --LLLDGAADdpeERREYLEIILEEAERLSRLVNDLldlsRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELEL 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 532 RVPEAEALVRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFE 611
Cdd:COG5002   267 DLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEG-----GTITVSLREEDD------QVRISVRDTGIGIPEEDLPRIFE 335

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2539247726 612 PFFT-----TKEIGqGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:COG5002   336 RFYRvdksrSRETG-GTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 405-657 1.51e-38

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 146.08  E-value: 1.51e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 405 HEIVDRTRAEaelratqDELVQASKLAALGQMAAGITHELNQPLAALRTFsdnTRILLERGQHGAATDNLQAIADLTERM 484
Cdd:COG5807   126 RDITKRKEAE-------DKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGF---LQLLQESREDSEREEYFNIIISEIDRI 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 485 GKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPR--LGDVRLELHwrVPEAEALVRADELKLEQVLINLIGNALDAI 562
Cdd:COG5807   196 NTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEaiLKNISIKYD--LADDEPVINGDKNQLKQVFINLIKNAIEAM 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 563 GANdaarpGRIDIdvgpaegvpSPLKQ---LSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGG 639
Cdd:COG5807   274 ETG-----GNITI---------KTYVEgdfVVISVKDEGIGIPEEVLEKIGEPFFTTKE--EGTGLGLSICKKIIEEHNG 337

                         250
                  ....*....|....*...
gi 2539247726 640 SLSAINMPDGGAQFTLTL 657
Cdd:COG5807   338 TIEVESKPGKGTTFTIYL 355
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 407-657 4.02e-35

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 139.34  E-value: 4.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 407 IVDRTraeaELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDntriLLERGQHGAATDNLQAIADLTERMGK 486
Cdd:COG5809   248 FRDIT----ERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQ----LLKDTIDEEQKTYLDIMLSELDRIES 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 487 ITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIgand 566
Cdd:COG5809   320 IISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM---- 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 567 aARPGRIDIDVGPAEGvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGGSLSAINM 646
Cdd:COG5809   396 -PEGGNITIETKAEDD-----DKVVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGLMVSYKIIEEHGGKITVESE 467

                         250
                  ....*....|.
gi 2539247726 647 PDGGAQFTLTL 657
Cdd:COG5809   468 VGKGTTFSITL 478
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
390-662 6.56e-35

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 140.49  E-value: 6.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 390 EDRTADLMATNEQL---QHEIV-------DRTraeaELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFsdnTR 459
Cdd:PRK11360  341 RDRTIELSVSTSLLhntHGEMIgalvifsDLT----ERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY---VQ 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 460 ILLERGQHGAATDNLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEAL 539
Cdd:PRK11360  414 IWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPP 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 540 VRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVG-PAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKE 618
Cdd:PRK11360  494 IWADPELLKQVLLNILINAVQAISAR-----GKIRIRTWqYSDG------QVAVSIEDNGCGIDPELLKKIFDPFFTTKA 562

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2539247726 619 igQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRAEV 662
Cdd:PRK11360  563 --KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 181-657 4.48e-32

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 130.68  E-value: 4.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 181 VGRFYGIGITREEPGYYISQPVMQDGRVIGVTVVKLNLEWFGRASHDASEPVMVADEHGVIFLSSVPAWQYRTVEPITPE 260
Cdd:COG4251    32 LALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 261 LNAHLEATRQYYRKQITPLPLRPEVPAFLKLVGRLPEGAQLVRVGDRINATRYLLVSRELIEPDWELMYLTPVDPVMSAA 340
Cdd:COG4251   112 LLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 341 RSATVAAAFAFAFACLLLFYWRQRRLRLMEMLRSRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRAT 420
Cdd:COG4251   192 LLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEER 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 421 QDELVQASKlaALGQMAAGITHELNQPLAALRTFSDntrILLERGQHGA---ATDNLQAIADLTERMGKITAQLKLFA-- 495
Cdd:COG4251   272 TAELERSNE--ELEQFAYVASHDLREPLRKISGFSQ---LLEEDYGDKLdeeGREYLERIRDAAERMQALIDDLLAYSrv 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 496 GRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWR-VPEaealVRADELKLEQVLINLIGNALDaigANDAARPGRID 574
Cdd:COG4251   347 GRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGpLPT----VRGDPTLLRQVFQNLISNAIK---YSRPGEPPRIE 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 575 IDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFT--TKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQ 652
Cdd:COG4251   420 IGAEREGG------EWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGAT 493


                  ....*
gi 2539247726 653 FTLTL 657
Cdd:COG4251   494 FYFTL 498
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 407-657 3.63e-30

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 124.84  E-value: 3.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 407 IVDRTRAEAELRatqdelvQASKLAALGQMAAGITHELNQPLAALRTFsdntrilLERGQHGAATDN--LQAIADLTERM 484
Cdd:COG5805   268 ITEKKEAEELMA-------RSEKLSIAGQLAAGIAHEIRNPLTSIKGF-------LQLLQPGIEDKEeyFDIMLSELDRI 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 485 GKITAQLkLFAGR----SRRK---HSDVQVRVALDHSLALLRprlgDVRLELHWRVPEAEalVRADELKLEQVLINLIGN 557
Cdd:COG5805   334 ESIISEF-LALAKpqavNKEKeniNELIQDVVTLLETEAILH----NIQIRLELLDEDPF--IYCDENQIKQVFINLIKN 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 558 ALDAIgandaARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDF 637
Cdd:COG5805   407 AIEAM-----PNGGTITIHTEEEDN------SVIIRVIDEGIGIPEERLKKLGEPFFTTKE--KGTGLGLMVSYKIIENH 473

                         250       260
                  ....*....|....*....|
gi 2539247726 638 GGSLSAINMPDGGAQFTLTL 657
Cdd:COG5805   474 NGTIDIDSKVGKGTTFTITL 493
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 542-657 9.56e-30

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 113.51  E-value: 9.56e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  542 ADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEI-- 619
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEG-----GRITVTLERDGD------HVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsr 69

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2539247726  620 -GQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:smart00387  70 kIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 3.54e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 111.39  E-value: 3.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGanDAARPgRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLG 626
Cdd:cd16976     1 IQQVLMNLLQNALDAMG--KVENP-RIRIAARRLGG------RLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLG 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2539247726 627 LAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16976    72 LSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
408-657 7.75e-29

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 122.86  E-value: 7.75e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 408 VDRTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLERGQHgaATDNLQAIADLTERMGKI 487
Cdd:PRK13837  425 IERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSR--AARYIDEIISAGARARLI 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 488 TAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDvRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANda 567
Cdd:PRK13837  503 IDQILAFGRKGERNTKPFDLSELVTEIAPLLRVSLPP-GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGA-- 579

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 568 arpGRIDIDV---------GPAEGVPSPLKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKeiGQGLGLGLAISTSIARDFG 638
Cdd:PRK13837  580 ---GRVDISLsraklrapkVLSHGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTR--AGGTGLGLATVHGIVSAHA 654

                         250
                  ....*....|....*....
gi 2539247726 639 GSLSAINMPDGGAQFTLTL 657
Cdd:PRK13837  655 GYIDVQSTVGRGTRFDVYL 673
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 409-657 9.94e-29

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 119.85  E-value: 9.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 409 DRTRAEaelRATQDElvQASKLAALGQMAAGITHELNQPLAALRTFsdntrILLERGQHGAATDNL--QAIADLTERMGK 486
Cdd:COG5808   222 RKTLLE---RVIQEI--NTQKLELIGTFAASTAHEIRNPLTSIKGF-----IQLLQEKYPELEDQKyfDIIQEEIQRINQ 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 487 ITAQLKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANd 566
Cdd:COG5808   292 IVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEG- 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 567 aarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGGSLSAINM 646
Cdd:COG5808   371 ----GKLTISIENDDE------KAVIEVIDNGEGIPEDIIDEIFEPFVTTKE--GGTGLGLSVCKRIVEMHGGEIDIESE 438

                         250
                  ....*....|.
gi 2539247726 647 PDGGAQFTLTL 657
Cdd:COG5808   439 EGKGTTFTIRL 449
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 547-657 2.42e-28

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 109.23  E-value: 2.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAigandAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEI--GQGLG 624
Cdd:cd00075     1 LEQVLSNLLDNALKY-----SPPGGTIEISLRQEGD------GVVLEVEDNGPGIPEEDLERIFERFYRGDKSreGGGTG 69

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2539247726 625 LGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd00075    70 LGLAIVRRIVEAHGGRITVESEPGGGTTFTVTL 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
410-657 6.22e-28

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 117.58  E-value: 6.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 410 RTRAEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSdntRILLERGQHGAATDNL-QAIADLTERMGKIT 488
Cdd:PRK10364  214 YRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLA---KYFAERAPAGGEAHQLaQVMAKEADRLNRVV 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 489 AQLKLFAGRSRRKHSDVQVRVALDHSLALLRprlGDVR---LELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGan 565
Cdd:PRK10364  291 SELLELVKPTHLALQAVDLNDLINHSLQLVS---QDANsreIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIG-- 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 566 daaRPGRIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKeiGQGLGLGLAISTSIARDFGGSLSAIN 645
Cdd:PRK10364  366 ---QHGVISVTASESG------AGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVAS 434

                         250
                  ....*....|..
gi 2539247726 646 MPDGGAQFTLTL 657
Cdd:PRK10364  435 QEGKGATFTLWL 446
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 542-657 5.68e-27

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 105.53  E-value: 5.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 542 ADELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEGVpsplkqlSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ 621
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKH-----AAKAGEITVTLSEGGEL-------TLTVEDNGIGIPPEDLPRIFEPFSTADKRGG 68

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2539247726 622 -GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:pfam02518  69 gGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 6.81e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 102.12  E-value: 6.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLG 626
Cdd:cd16943     4 LNQVLLNLLVNAAQAMEGR-----GRITIRTWAHV------DQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLG 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2539247726 627 LAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16943    73 LSLSYRIIQKHGGTIRVASVPGGGTRFTIIL 103
PRK13557 PRK13557
histidine kinase; Provisional
 418-640 1.92e-24

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 107.83  E-value: 1.92e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 418 RATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLE-----RGQHGAATDNlqaIADLTERMGKITAQLK 492
Cdd:PRK13557  148 RDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALShpdadRGRMARSVEN---IRAAAERAATLTQQLL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 493 LFAGRSRrkhsdVQVRVALDHSLA-----LLRPRLGD---VRLELhwrvpeAEAL--VRADELKLEQVLINLIGNALDAI 562
Cdd:PRK13557  225 AFARKQR-----LEGRVLNLNGLVsgmgeLAERTLGDavtIETDL------APDLwnCRIDPTQAEVALLNVLINARDAM 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 563 gandaARPGRIDI-----DVGPAE----GVPSPLKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLGLAISTSI 633
Cdd:PRK13557  294 -----PEGGRVTIrtrnvEIEDEDlamyHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGF 368


                  ....*..
gi 2539247726 634 ARDFGGS 640
Cdd:PRK13557  369 AKQSGGA 375
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 3.47e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 97.47  E-value: 3.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIgANDAARPGRIDIDVGPAEgvpspLKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLG 626
Cdd:cd16920     1 IQQVLINLVRNGIEAM-SEGGCERRELTIRTSPAD-----DRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMG 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2539247726 627 LAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16920    73 LSICRSIIEAHGGRLSVESPAGGGATFQFTL 103
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 415-657 4.44e-21

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 96.09  E-value: 4.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 415 AELRatqDELVQASKLAALGQMAAGITHELNQPLAALRTFsdntrILLERGQHGAATDNLQAIA------DLTERMgkIT 488
Cdd:COG5806   186 ILLR---KELQRAEKLEVVSELAASIAHEVRNPLTVVRGF-----IQLLQEPELSDEKRKQYIRialeelDRAEAI--IT 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 489 AQLKlFAgrsrRKHSDVQVRVALD----HSLALLRPrLGDVR-LELHWRVPEaEALVRADELKLEQVLINLIGNALDAIG 563
Cdd:COG5806   256 DYLT-FA----KPQPEKLEKIDVSeeleHVIDVLSP-YANMNnVEIQTELEP-GLYIEGDRQKLQQCLINIIKNGIEAMP 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 564 ANdaarpGRIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLGLAISTSIARDFGGSL-- 641
Cdd:COG5806   329 NG-----GTLTIDVSIDK------NKVIISIKDTGVGMTKEQLERLGEPYFSTKE--KGTGLGTMVSYRIIEAMNGTIrv 395

                         250
                  ....*....|....*..
gi 2539247726 642 -SAINMpdgGAQFTLTL 657
Cdd:COG5806   396 eSEVGK---GTTFTITL 409
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 441-660 1.38e-20

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 95.30  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 441 THELNQPLAALRTFSDntriLL------ERGQHGAATDNLQA--IADLTERMgkiTAQLKLFAGRSRRKHSDVQVRVALD 512
Cdd:PRK11100  264 THELKSPLAAIRGAAE----LLqedpppEDRARFTGNILTQSarLQQLIDRL---LELARLEQRQELEVLEPVALAALLE 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 513 HSLALLRPRLGDVRLELHWRVPEAEalVRADELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEGvpsplkQLSI 592
Cdd:PRK11100  337 ELVEAREAQAAAKGITLRLRPDDAR--VLGDPFLLRQALGNLLDNAIDF-----SPEGGTITLSAEVDGE------QVAL 403

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2539247726 593 AVRDNGPGIPPDTMPHLFEPFFTTKEIGQGL---GLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRA 660
Cdd:PRK11100  404 SVEDQGPGIPDYALPRIFERFYSLPRPANGRkstGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 547-657 3.59e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 86.01  E-value: 3.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNAL---DAigandaarpGRIDIDVGpAEGVPSPLKQLSIAVRDNGPGIPPDTMPHLFEPFF-----TTKE 618
Cdd:cd16922     1 LRQILLNLLGNAIkftEE---------GEVTLRVS-LEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadssTTRK 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2539247726 619 IGqGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16922    71 YG-GTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTL 108
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 547-657 8.94e-19

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 82.43  E-value: 8.94e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGandaaRPGRIDI----DVGPAEGVPS-----PLKQLSIAVRDNGPGIPPDTMPHLFEPFFTTK 617
Cdd:cd16919     1 LELAILNLAVNARDAMP-----EGGRLTIetsnQRVDADYALNyrdliPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTK 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2539247726 618 EIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16919    76 EVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 412-657 2.22e-18

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 87.60  E-value: 2.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 412 RAEAELRATQDELVQASKLAalgQMAAGITHELNQPLAALRTfsdntriLLERGQHGAAtdnLQAIADLTERMGKITaql 491
Cdd:COG3290   171 RDRTELERLEEELEGVKELA---EALRAQRHDFRNHLHTISG-------LLQLGEYDEA---LEYIDEISEELQELI--- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 492 klfaGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEAlvraDELKLEQVLINLIGNALDAIGANDAARPg 571
Cdd:COG3290   235 ----DSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPL----SDTDLVTILGNLLDNAIEAVEKLPEEER- 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 572 RIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEiGQGLGLGLAISTSIARDFGGSLSAINMPDGGA 651
Cdd:COG3290   306 RVELSIRDDGD------ELVIEVEDSGPGIPEELLEKIFERGFSTKL-GEGRGLGLALVKQIVEKYGGTIEVESEEGEGT 378


                  ....*.
gi 2539247726 652 QFTLTL 657
Cdd:COG3290   379 VFTVRL 384
PRK10604 PRK10604
sensor protein RstB; Provisional
 430-657 1.29e-17

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 85.81  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 430 LAALGQMAAGITHELNQPLAALR---TFSDNtrilLERGQHGAATDNLQAIADLTERMgkitaqlkLFAGRSRRKHSDVQ 506
Cdd:PRK10604  209 IASKKQLIDGIAHELRTPLVRLRyrlEMSDN----LSAAESQALNRDIGQLEALIEEL--------LTYARLDRPQNELH 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 507 VrVALDhSLALLRPRLGDVRL-----ELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGandaarpGRIDIdvgpae 581
Cdd:PRK10604  277 L-SEPD-LPAWLSTHLADIQAvtpekTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAH-------SRVRV------ 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 582 GVPSPLKQLSIAVRDNGPGIPPDTMPHLFEPFF-----TTKEIGqGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLT 656
Cdd:PRK10604  342 SLLLDGNQACLIVEDDGPGIPPEERERVFEPFVrldpsRDRATG-GCGLGLAIVHSIALAMGGSVNCDESELGGARFSFS 420


                  .
gi 2539247726 657 L 657
Cdd:PRK10604  421 W 421
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 543-657 1.03e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 76.04  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 543 DELKLEQVLINLIGNALDAIGANDAARP-GRIDIDVGPAEgvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGq 621
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIEGRPSDVGeVRIRVEADQDG-------RIVLIVCDNGKGFPREMRHRATEPYVTTRPKG- 72

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2539247726 622 gLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16944    73 -TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 1.35e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 75.90  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGANDAARPGRIDIDVGPAEGVPSPLKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEigQGLGLG 626
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRE--NGTGLG 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2539247726 627 LAISTSIARDFGGSLSAINMPdGGAQFTLTL 657
Cdd:cd16918    79 LAIAQNIVSQHGGVIECDSQP-GHTVFSVSL 108
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 553-657 1.64e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 72.71  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 553 NLIGNALDAIGANDAArPGRIDIDVGpAEGvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGqGLGLGLAISTS 632
Cdd:cd16915     7 NLIDNALDALAATGAP-NKQVEVFLR-DEG-----DDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQ 78

                          90       100
                  ....*....|....*....|....*
gi 2539247726 633 IARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16915    79 SVERLGGSITVESEPGGGTTFSIRI 103
PRK10490 PRK10490
sensor protein KdpD; Provisional
 514-657 3.38e-15

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 79.69  E-value: 3.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 514 SLALLRPRLGDVRLELhwRVPEAEALVRADELKLEQVLINLIGNALDAigANDAARPGrIDIDVGPaegvpsplKQLSIA 593
Cdd:PRK10490  748 ALQMLEPGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLENAVKY--AGAQAEIG-IDAHVEG--------ERLQLD 814

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2539247726 594 VRDNGPGIPPDTMPHLFEPFFT-TKEIG-QGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK10490  815 VWDNGPGIPPGQEQLIFDKFARgNKESAiPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 433-657 5.52e-15

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 77.81  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 433 LGQMAAGITHELNQPLAALRTfsdNTRILLERGQHGAA-TDNLQAIADLTERMGKITAQLKLFA----GRSRRKHSDVQV 507
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLG---QTQVALSQPRTGEEyREVLESNLEELERLSRMVSDMLFLAradnGQLALERVRLDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 508 RVALDHSLALLRPrLGD---VRLELhwrvpEAEALVRADELKLEQVLINLIGNALdaigaNDAARPGRIDIDVGPAEGvp 584
Cdd:TIGR01386 318 AAELAKVAEYFEP-LAEergVRIRV-----EGEGLVRGDPQMFRRAISNLLSNAL-----RHTPDGGTITVRIERRSD-- 384

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2539247726 585 splkQLSIAVRDNGPGIPPDTMPHLFEPFF----TTKEIGQGLGLGLAISTSIARDFGGSLSAiNMPDGGAQFTLTL 657
Cdd:TIGR01386 385 ----EVRVSVSNPGPGIPPEHLSRLFDRFYrvdpARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
PRK15347 PRK15347
two component system sensor kinase;
378-657 5.65e-15

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 78.92  E-value: 5.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 378 LETAYDQLERRVEDRTADLmatneqlqheivDRTRAEAElratqdelvQASKLAALgqMAAGITHELNQPL----AALR- 452
Cdd:PRK15347  366 LNEQYDTLENKVAERTQAL------------AEAKQRAE---------QANKRKSE--HLTTISHEIRTPLngvlGALEl 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 453 ----TFSDNTRILLERGQHgaATDNLQAI-----------ADLTERMGKITAQLKLFagrsrrkhsD-----VQVRvALD 512
Cdd:PRK15347  423 lqntPLTAEQMDLADTARQ--CTLSLLAIinnlldfsrieSGQMTLSLEETALLPLL---------DqamltIQGP-AQS 490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 513 HSLALlRPRLG-DVRLELHwrvpeaealvrADELKLEQVLINLIGNALDAIGAndaarpGRIDIDVGPAEgvpsplKQLS 591
Cdd:PRK15347  491 KSLTL-RTFVGaHVPLYLH-----------LDSLRLRQILVNLLGNAVKFTET------GGIRLRVKRHE------QQLC 546

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2539247726 592 IAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK15347  547 FTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 367-657 7.46e-15

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 78.41  E-value: 7.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 367 RLMEMLRSR-RMLETAYDQLERRVEDRTADLMATneQLQHEivdRTRAEAElRATQdelvqaSKLAALGQMaagiTHELN 445
Cdd:PRK11466  393 RLMDAFRSNvHALNRHREQLAAQVKARTAELQEL--VIEHR---QARAEAE-KASQ------AKSAFLAAM----SHEIR 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 446 QPLAALRtfsDNTRILLERGQHGAATDNLQAIADLTERMGKITAQL----KLFAGRSRRKHSD--VQVRVALDHSLALLR 519
Cdd:PRK11466  457 TPLYGIL---GTAQLLADNPALNAQRDDLRAITDSGESLLTILNDIldysAIEAGGKNVSVSDepFEPRPLLESTLQLMS 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 520 PRLGDVRLELHWRVPEA-EALVRADELKLEQVLINLIGNALDAigandaARPGRIDIDVGPAEgvpsplKQLSIAVRDNG 598
Cdd:PRK11466  534 GRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRF------TDEGSIVLRSRTDG------EQWLVEVEDSG 601

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2539247726 599 PGIPPDTMPHLFEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK11466  602 CGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 1.33e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 70.05  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAigandaaRPGRIDIDVGpAEGvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ----G 622
Cdd:cd16949     1 LARALENVLRNALRY-------SPSKILLDIS-QDG-----DQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDresgG 67

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2539247726 623 LGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16949    68 TGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWL 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 543-657 1.65e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 69.80  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 543 DELKLEQVLINLIGNALDAIGANdaarpGRIDIDvgpAEGVPsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKE---- 618
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTG-----GKLRIR---AAQTP---QEVRLDVEDSAPGVSDDQLARLFERFYRVESsrnr 69

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2539247726 619 IGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16946    70 ASGGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTL 108
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 72-270 1.86e-13

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 70.44  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  72 LSQAQQAAGGRVDRYAANLKSTLDRYEYLPALIALHPFIHDLLANPTPENVARANRYLlevNDRAHATATYVIAPSGQAL 151
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLL---RSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 152 AASNYnqPDSFVGAEYRFRPYFQQAAAG-----HVGRFYGIGITREEPGYYISQPVMQD-GRVIGVTVVKLNLEWFGR-- 223
Cdd:pfam02743  81 ASSDE--SPSYPGLDVSERPWYKEALKGgggiiWVFSSPYPSSESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQEll 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2539247726 224 --ASHDASEPVMVADEHGVIFLSSVPAWQYRTVEPITPELNAHLEATRQ 270
Cdd:pfam02743 159 sqIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSG 207
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 2.64e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 66.44  E-value: 2.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGANDaarpGRIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTK----EIGQG 622
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDT----GRITVSAMPTG------KMVTISVEDEGPGIPQEKLESIFDRFYTERpaneAFGQH 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2539247726 623 LGLGLAISTSIARDFGGSLSA--INMPDG--GAQFTLTL 657
Cdd:cd16953    71 SGLGLSISRQIIEAHGGISVAenHNQPGQviGARFTVQL 109
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-659 5.05e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 65.53  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALdaigaNDAARPGRIDIDVGpaegvpspLKQLSIAVRDNGPGIPPDTMPHLFEPFF-----TTKEIGq 621
Cdd:cd16939     1 MARALDNLLRNAL-----RYAHRTVRIALLVS--------GGRLTLIVEDDGPGIPAAARERVFEPFVrldpsRDRATG- 66

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2539247726 622 GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVR 659
Cdd:cd16939    67 GFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWPR 104
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-657 9.90e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 64.66  E-value: 9.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNAldaIGANDAARPGRIDIDVGPAEGVPSplkqlsIAVRDNGPGIPPDTMPHLFEPF--FTTKEIGQGLG 624
Cdd:cd16921     1 LGQVLTNLLGNA---IKFRRPRRPPRIEVGAEDVGEEWT------FYVRDNGIGIDPEYAEKVFGIFqrLHSREEYEGTG 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2539247726 625 LGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16921    72 VGLAIVRKIIERHGGRIWLESEPGEGTTFYFTL 104
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 543-657 1.20e-11

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 61.74  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 543 DELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEGvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ- 621
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKF-----TPDGGRIRCILEKFRL-----NRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTr 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2539247726 622 ---GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16925    71 ahgGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVEL 109
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-650 3.75e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 60.16  E-value: 3.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALdaigandaaRPGRIDIDVGpAEGVPsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEI--GQGLG 624
Cdd:cd16950     1 LKRVLSNLVDNAL---------RYGGGWVEVS-SDGEG---NRTRIQVLDNGPGIAPEEVDELFQPFYRGDNArgTSGTG 67

                          90       100
                  ....*....|....*....|....*.
gi 2539247726 625 LGLAISTSIARDFGGSLSAINMPDGG 650
Cdd:cd16950    68 LGLAIVQRISDAHGGSLTLANRAGGG 93
PRK09303 PRK09303
histidine kinase;
383-657 5.49e-11

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 64.97  E-value: 5.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 383 DQLERRVEDRTADLMATN---EQLQHEIVDRTRAEAELRATQDELVQ--------ASKLAALGQMAAGITHELNQPLA-- 449
Cdd:PRK09303   90 QQLKNWWPRWQQEGATYSglgENLQPSEIDSGRYSQELLQLSDELFVlrqenetlLEQLKFKDRVLAMLAHDLRTPLTaa 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 450 --ALRTfsdntrilLERGQHGAATDNLQAiadLTERMGK-ITAQLK---------LFAGRSRRKHSDVQ-VRVALDhSLA 516
Cdd:PRK09303  170 slALET--------LELGQIDEDTELKPA---LIEQLQDqARRQLEeierlitdlLEVGRTRWEALRFNpQKLDLG-SLC 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 517 L-----LRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVgpaegvpspLKQLS 591
Cdd:PRK09303  238 QevileLEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEG-----GTITLSM---------LHRTT 303

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2539247726 592 ----IAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ--GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK09303  304 qkvqVSICDTGPGIPEEEQERIFEDRVRLPRDEGteGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTL 375
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 414-650 6.88e-11

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 64.93  E-value: 6.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 414 EAELRATQDELVQASKLAALGQMAAGITHELNQPLAALrtfSDNTRILLERGQHG---AATDNLQAIadLTERMGKITAQ 490
Cdd:TIGR02938 257 RARLSALQALMAEEERLEAIRETLSAAIHRLQGPMNLI---SAAISVLQRRGDDAgnpASAAMLQQA--LSAGREHMEAL 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 491 LKLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANDAARP 570
Cdd:TIGR02938 332 RQVIPQSPQEIVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAATLPAILGRELQLRSLFKALVDNAIEAMNIKGWKRR 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 571 gridiDVGPAEGVPSPLkqLSIAVRDNGPGIPPDTMPHLFEPFFTTK-EIGQGLGLGLAISTSIARDFGGSLSAINMPDG 649
Cdd:TIGR02938 412 -----ELSITTALNGDL--IVVSILDSGPGIPQDLRYKVFEPFFTTKgGSRKHIGMGLSVAQEIVADHGGIIDLDDDYSE 484


                  .
gi 2539247726 650 G 650
Cdd:TIGR02938 485 G 485
envZ PRK09467
osmolarity sensor protein; Provisional
 406-659 8.84e-11

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 64.55  E-value: 8.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 406 EIVDRTRAEAELRATQDELVQASKLaalgqMAAGITHELNQPLaalrtfsdnTRILLERGQHGAATDNL-QAIADLTERM 484
Cdd:PRK09467  207 EVRSVTRAFNQMAAGIKQLEDDRTL-----LMAGVSHDLRTPL---------TRIRLATEMMSEEDGYLaESINKDIEEC 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 485 GKITAQ----LKLFAGRSRrkhSDVQVRVALDHSLALLRPRLGDVRLELhwrvPEAEALVRADELKLEQVLINLIGNALd 560
Cdd:PRK09467  273 NAIIEQfidyLRTGQEMPM---EMADLNALLGEVIAAESGYEREIETAL----QPGPIEVPMNPIAIKRALANLVVNAA- 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 561 aigandaaRPGRIDIDVgpAEGVPspLKQLSIAVRDNGPGIPPDTMPHLFEPfFTTKEI---GQGLGLGLAISTSIARDF 637
Cdd:PRK09467  345 --------RYGNGWIKV--SSGTE--GKRAWFQVEDDGPGIPPEQLKHLFQP-FTRGDSargSSGTGLGLAIVKRIVDQH 411

                         250       260
                  ....*....|....*....|....
gi 2539247726 638 GGSLSAINMPDGG--AQFTLTLVR 659
Cdd:PRK09467  412 NGKVELGNSEEGGlsARAWLPLTT 435
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 550-657 1.49e-10

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 64.16  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 550 VLINLIGNALDAIGANDAarpGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKeiGQGLGLGLAI 629
Cdd:PRK11086  437 ILGNLIENALEAVGGEEG---GEISVSLHYRNG------WLHCEVSDDGPGIAPDEIDAIFDKGYSTK--GSNRGVGLYL 505

                          90       100
                  ....*....|....*....|....*...
gi 2539247726 630 STSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK11086  506 VKQSVENLGGSIAVESEPGVGTQFFVQI 533
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
411-657 1.49e-10

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 63.88  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 411 TRAEAelrATQDELVQ--------ASKLAALGQM----AAGITHELNQPLAALRTfsdntriLLERGQHGAATDNLQAIA 478
Cdd:PRK10549  209 TRVTP---TSRDELGRlaqdfnqlASTLEKNEQMrrdfMADISHELRTPLAVLRG-------ELEAIQDGVRKFTPESVA 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 479 DLTERMGKITA------QLKLF---AGRSRRKHSDVqVRVaLDHSLALLRPRLGDVRLELHWRVPEaEALVRADELKLEQ 549
Cdd:PRK10549  279 SLQAEVGTLTKlvddlhQLSLSdegALAYRKTPVDL-VPL-LEVAGGAFRERFASRGLTLQLSLPD-SATVFGDPDRLMQ 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 550 VLINLIGNALDAIGANdaarpGRIDIdvgpaEGVPSPlKQLSIAVRDNGPGIPPDTMPHLFEPFFTTK----EIGQGLGL 625
Cdd:PRK10549  356 LFNNLLENSLRYTDSG-----GSLHI-----SAEQRD-KTLRLTFADSAPGVSDEQLQKLFERFYRTEgsrnRASGGSGL 424

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2539247726 626 GLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK10549  425 GLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
533-655 3.56e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 63.45  E-value: 3.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 533 VPEAealVRADELKLEQVLINLIGNAldaIGANDAarpGRIDIDVGPAEGVpsplkqLSIAVRDNGPGIPPDTMPHLFEP 612
Cdd:PRK10841  552 VPVA---LNGDPMRLQQVISNLLSNA---IKFTDT---GCIVLHVRVDGDY------LSFRVRDTGVGIPAKEVVRLFDP 616

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2539247726 613 FFttkEIG-------QGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTL 655
Cdd:PRK10841  617 FF---QVGtgvqrnfQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTI 663
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 540-657 1.18e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 56.26  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 540 VRADELKLEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGVpsplkqlSIAVRDNGPGIPPDTMPHLFEPFF-TTKE 618
Cdd:cd16940     7 VQGDALLLFLLLRNLVDNAVRYSPQG-----SRVEIKLSADDGA-------VIRVEDNGPGIDEEELEALFERFYrSDGQ 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2539247726 619 IGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16940    75 NYGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
glnL PRK11073
nitrogen regulation protein NR(II);
418-635 4.11e-09

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 58.94  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 418 RATQDELVQASKLAAlGQMAAGITHELNQPLAALRtfsdntrillergqhGAATDNLQAIAD--LTERMGKITAQlklfA 495
Cdd:PRK11073  116 RLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLR---------------GAAQLLSKALPDpaLTEYTKVIIEQ----A 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 496 GRSRR--------KHSDVQVRVALDHSLALLRpRLgdVRLELhwrvPEAEALVR----------ADELKLEQVLINLIGN 557
Cdd:PRK11073  176 DRLRNlvdrllgpQRPGTHVTESIHKVAERVV-QL--VSLEL----PDNVRLIRdydpslpelaHDPDQIEQVLLNIVRN 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 558 ALDAIGANDaarpGRIDIDVGPAEGVPSPLKQLSIAVR----DNGPGIPPDTMPHLFEPFFTTKEIGQGLGLglaistSI 633
Cdd:PRK11073  249 ALQALGPEG----GTITLRTRTAFQLTLHGERYRLAARidieDNGPGIPPHLQDTLFYPMVSGREGGTGLGL------SI 318


                  ..
gi 2539247726 634 AR 635
Cdd:PRK11073  319 AR 320
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 396-658 1.10e-08

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 58.32  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 396 LMATNEQLQHEIvDRtrAEAELRAT------QD-ELVQASKLAalgQMAAGI--------THELNQPLAALRTFsdnTRI 460
Cdd:PRK11107  247 LSAYHEEMQQNI-DQ--ATSDLRETleqmeiQNvELDLAKKRA---QEAARIkseflanmSHELRTPLNGVIGF---TRQ 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 461 LLERGQHGAATDNLQAIadltER-----MGKITAQL---KLFAGRSRRKHSDVQVRVALDHSLALLRPRLGDVRLEL--- 529
Cdd:PRK11107  318 TLKTPLTPTQRDYLQTI----ERsannlLAIINDILdfsKLEAGKLVLENIPFSLRETLDEVVTLLAHSAHEKGLELtln 393

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 530 -HWRVPEAealVRADELKLEQVLINLIGNaldAIGANDAarpGRIDIDV----GPAEGVpsplkQLSIAVRDNGPGIPPD 604
Cdd:PRK11107  394 iDPDVPDN---VIGDPLRLQQIITNLVGN---AIKFTES---GNIDILVelraLSNTKV-----QLEVQIRDTGIGISER 459

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2539247726 605 TMPHLFEPFfttkeiGQ----------GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLV 658
Cdd:PRK11107  460 QQSQLFQAF------RQadasisrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
588-657 1.44e-08

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 57.63  E-value: 1.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2539247726 588 KQLSIAVRDNGPGIPPDTMPHLFEPFFTT-----KEIGqGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK09470  382 DGLTITVDDDGPGVPEEEREQIFRPFYRVdeardRESG-GTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 551-657 1.75e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 53.40  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 551 LINLIGNALDaiganDAAR--PGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQGLGLGLA 628
Cdd:cd16954    38 LMELLGNLLD-----NACKwcLEFVEVTARQTDG------GLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLA 106

                          90       100
                  ....*....|....*....|....*....
gi 2539247726 629 ISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16954   107 IAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 430-495 1.46e-07

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 48.75  E-value: 1.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2539247726 430 LAALGQMAAGITHELNQPLAALRTFSDntriLLERGQHGAAT--DNLQAIADLTERMGKITAQLKLFA 495
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALE----LLEEELLDDEEqrEYLERIREEAERLLRLINDLLDLS 64
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 543-657 1.75e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 49.77  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 543 DELKLEQVLINLIGNAldaigandaarpgridIDVGPAEGVPSPL-----KQLSIAVRDNGPGIPPDTMPHLFEPFFTTK 617
Cdd:cd16945     1 DPFLLRQAINNLLDNA----------------IDFSPEGGLIALQleadtEGIELLVFDEGSGIPDYALNRVFERFYSLP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2539247726 618 EIGQG---LGLGLAISTSIARDFGGSLSAINMPDGGAQFtLTL 657
Cdd:cd16945    65 RPHSGqksTGLGLAFVQEVAQLHGGRITLRNRPDGVLAF-LTL 106
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 528-657 1.86e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 50.20  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 528 ELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGAndaarpGR-IDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTM 606
Cdd:cd16947     2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSD------GKfLGMTLREDE------KHVYIDIWDKGKGISETEK 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2539247726 607 PHLFEPFFTTKEIG----QGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16947    70 DHVFERLYTLEDSRnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 432-495 6.26e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 46.82  E-value: 6.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2539247726 432 ALGQMAAGITHELNQPLAALRTFSDntrILLERGQHGAATDNLQAIADLTERMGKITAQLKLFA 495
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLE---LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLS 61
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 538-658 3.20e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 50.32  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 538 ALVRADELKLEQVLINLIGNALDAigandaARPGRIDIDVGPAEGvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTK 617
Cdd:PRK11091  390 HKVITDGTRLRQILWNLISNAVKF------TQQGGVTVRVRYEEG-----DMLTFEVEDSGIGIPEDELDKIFAMYYQVK 458

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2539247726 618 EIGQGL-----GLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLV 658
Cdd:PRK11091  459 DSHGGKpatgtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
383-650 3.52e-06

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 49.58  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 383 DQLERRVEDRTADlmatneQLQ--------HEIVDRTRAEAELRATQDELVQASKLaalgqMAAGITHELNQPLAALRTF 454
Cdd:PRK10755   90 AELQKELEARTAD------NLTpiaihsstLEIEAVTSALNQLVSRLTSTLDQERL-----FTADVAHELRTPLAGIRLH 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 455 SDntriLLERgQHGAATDNLQAIADlteRMGKITAQLKLFAGRSRRKHSDVQVRVALDHSLAL-----LRPRLGDVRLEL 529
Cdd:PRK10755  159 LE----LLEK-QHHIDVAPLIARLD---QMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILpsqdeLSEMLEQRQQTL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 530 HWRVPEAEALVRADELKLEQVLINLIGNAldaigANDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHL 609
Cdd:PRK10755  231 LLPESAADITVQGDATLLRLLLRNLVENA-----HRYSPEGSTITIKLSQEDG------GAVLAVEDEGPGIDESKCGEL 299

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2539247726 610 FEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDGG 650
Cdd:PRK10755  300 SKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERS 340
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 554-617 4.34e-06

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 47.82  E-value: 4.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2539247726 554 LIGNALDAiGANdaarpgRIDIDVGPAegvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTK 617
Cdd:cd16926    21 LVENSIDA-GAT------RIDVEIEEG-------GLKLIRVTDNGSGISREDLELAFERHATSK 70
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 432-495 5.11e-06

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 44.48  E-value: 5.11e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2539247726  432 ALGQMAAGITHELNQPLAALRTFSDntrILLERGQHGAATDNLQAIADLTERMGKITAQLKLFA 495
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLE---LLLDTELSEEQREYLETILREAERLLRLINDLLDLS 61
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
457-625 5.35e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 49.25  E-value: 5.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 457 NTrilLERGQHGAATDNLQAIADLTERMGKitaqlkLFAGRSRRKHSDVQVRVALDHS---LALLRPRLGDvRLELHWRV 533
Cdd:COG2972   258 NT---LNSIRWLAELEDPEEAEEMLEALSK------LLRYSLSKGDELVTLEEELELIksyLEIQKLRFGD-RLEVEIEI 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 534 PEA--EALVradeLKLeqVLINLIGNALDAiGANDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPHLFE 611
Cdd:COG2972   328 DEEllDLLI----PKL--ILQPLVENAIEH-GIEPKEGGGTIRISIRKEGD------RLVITVEDNGVGMPEEKLEKLLE 394

                         170
                  ....*....|....
gi 2539247726 612 PFFTTKEiGQGLGL 625
Cdd:COG2972   395 ELSSKGE-GRGIGL 407
PRK10337 PRK10337
sensor protein QseC; Provisional
 591-656 1.12e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 48.49  E-value: 1.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2539247726 591 SIAVRDNGPGIPPDTMPHLFEPFFttKEIGQ---GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLT 656
Cdd:PRK10337  382 NFTVRDNGPGVTPEALARIGERFY--RPPGQeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 94-218 3.44e-05

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 43.91  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  94 LDRYEYLPALIALHPFIHDLLANPTPENVARANRYlleVNDRAHATATYVIAPSGQALAASNynqPDSFVGAEYRFRPYF 173
Cdd:cd12914     1 LDEADLLLRSLADDLEARGAASADPAALQALLRRL---LARLPEVRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYF 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2539247726 174 QQAAAGHVGRFYG---IGITREEPGYYISQPVM-QDGRVIGVTVVKLNL 218
Cdd:cd12914    75 QAARAGGGGLFISepvISRVTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 543-655 6.11e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 42.45  E-value: 6.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 543 DELKLEQVLINLIGNALDAigandAARPGRIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFFTTKEI--- 619
Cdd:cd16975     1 DTLLLSRALINIISNACQY-----APEGGTVSISIYDEE------EYLYFEIWDNGHGFSEQDLKKALELFYRDDTSrrs 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2539247726 620 GQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTL 655
Cdd:cd16975    70 GGHYGMGLYIAKNLVEKHGGSLIIENSQKGGAEVTV 105
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 361-572 8.66e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 8.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 361 WRQRRLRLMEMLRSRRMLETAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRATQDELVQASKLAALGQMAAgi 440
Cdd:COG1196   381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE-- 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 441 tHELNQPLAALRTfsdntrilLERGQHGAATDNLQAIADLTERMGKITAQLKLFAGRSRRkhsdvqvrVALDHSLALLRP 520
Cdd:COG1196   459 -EALLELLAELLE--------EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG--------VKAALLLAGLRG 521

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2539247726 521 RLGDVRLELHWRVPEAEALVRADELKLEQVLINLIGNALDAIGANDAARPGR 572
Cdd:COG1196   522 LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGR 573
PDC1_HK_sensor cd18773
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ...
 94-218 9.98e-05

first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350341 [Multi-domain]  Cd Length: 125  Bit Score: 42.55  E-value: 9.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  94 LDRYEYLPALIALHPFIHDLLANPTPENVARANRYLLEVNDraHATATYVIAPSGQALAASNYNQPDSFVGAEYRFRPYF 173
Cdd:cd18773     1 LEEADLLLRSLASALEALAALGSADREELQALLRRLLERNP--EISGIYVVDADGRVVASSDRDPGGGDDDDDRDRFWYQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2539247726 174 QQAAAG--HVGRFYgIGITREEPGYYISQPVM-QDGRVIGVTVVKLNL 218
Cdd:cd18773    79 AAKATGklVISEPY-ISRVTGKPVITLSRPIRdADGRFIGVVGADIDL 125
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
438-629 1.37e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 45.00  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 438 AGITHELNQPLAALRTF----SDNTrilLERGQHGAAtdnLQAIADLTERMGKITAQLKLFAGRSRRKHSDVQVRVALDH 513
Cdd:PRK11006  209 ANVSHELRTPLTVLQGYlemmQDQP---LEGALREKA---LHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPM 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 514 SLALLRPR---LGDVRLELHWRVPEAEAlVRADELKLEQVLINLIGNALdaigaNDAARPGRIDID-VGPAEGVpsplkQ 589
Cdd:PRK11006  283 MLRVLEREaqtLSQGKHTITFEVDNSLK-VFGNEDQLRSAISNLVYNAV-----NHTPEGTHITVRwQRVPQGA-----E 351

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2539247726 590 LSiaVRDNGPGIPPDTMPHLFEPFF-----TTKEIGqGLGLGLAI 629
Cdd:PRK11006  352 FS--VEDNGPGIAPEHIPRLTERFYrvdkaRSRQTG-GSGLGLAI 393
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 592-654 2.34e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 41.03  E-value: 2.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2539247726 592 IAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ----GLGLGLAISTSIARDFGGSLSAINMPDGGAQFT 654
Cdd:cd16952    35 LSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDARLLIASELGKGSRFT 101
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 589-657 3.55e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 40.35  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2539247726 589 QLSIAvrDNGPGIPPDTMPHLFEPFFTTK---EIGQGLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:cd16948    39 VLSIK--DFGIGIPEEDLPRVFDKGFTGEngrNFQESTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITF 108
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
588-664 6.52e-04

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 42.70  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 588 KQLSIAVRDNGPGIPPDTMPHLFEPffttkeiGQ-------GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTLVRA 660
Cdd:PRK10815  407 EHLHIVVEDDGPGIPESKRELIFDR-------GQradtlrpGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQ 479


                  ....
gi 2539247726 661 EVTS 664
Cdd:PRK10815  480 HSTP 483
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 547-647 1.05e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 40.40  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAI----GANDAARPgriDIDVGPAEGVPSplkqLSIAVRDNGPGIPPDTMPHLFEPFFTTKEIGQ- 621
Cdd:cd16929    44 LYYILFELLKNAMRATveshGDDSDDLP---PIKVTVAKGDED----LTIKISDRGGGIPREDLARLFSYMYSTAPQPSl 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2539247726 622 ----------------GLGLGLAISTSIARDFGGSLSAINMP 647
Cdd:cd16929   117 ddfsdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSME 158
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 383-550 1.27e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 41.13  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 383 DQLERRVEDRTADLMATNEQLQHEivdrtraEAELRATQDELVQASK-LAALGQMAAGITHELNQPLAALRTFSDNTRIL 461
Cdd:pfam12795  81 EELEQRLLQTSAQLQELQNQLAQL-------NSQLIELQTRPERAQQqLSEARQRLQQIRNRLNGPAPPGEPLSEAQRWA 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 462 L--ERGQHGAATDNL-QAIADLTERMGKITAQLKLFAGRSRRkhsdvqvrvaLDHSLALLRPRLGDVRLElhwrvpEAEA 538
Cdd:pfam12795 154 LqaELAALKAQIDMLeQELLSNNNRQDLLKARRDLLTLRIQR----------LEQQLQALQELLNEKRLQ------EAEQ 217

                         170
                  ....*....|..
gi 2539247726 539 LVRADELKLEQV 550
Cdd:pfam12795 218 AVAQTEQLAEEA 229
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
564-638 1.29e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.13  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2539247726 564 ANDAARPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTMPhlfEPFFTTKEigqgLGLGLAISTSIARDFG 638
Cdd:COG2172    50 AYGGDPDGPVEVELELDPD------GLEIEVRDEGPGFDPEDLP---DPYSTLAE----GGRGLFLIRRLMDEVE 111
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
539-657 1.32e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 42.03  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726  539 LVRADELKLEQVLINLIGNALDaIGANDAARPGRIDIDVGPAEGVpsplkqLSIAVRDNGPGIPPDTMPHLFEPFFTTKE 618
Cdd:PRK09959   821 LVKIDPQAFKQVLSNLLSNALK-FTTEGAVKITTSLGHIDDNHAV------IKMTIMDSGSGLSQEEQQQLFKRYSQTSA 893

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2539247726  619 IGQ--GLGLGLAISTSIARDFGGSLSAINMPDGGAQFTLTL 657
Cdd:PRK09959   894 GRQqtGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
top6b TIGR01052
DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type ...
 547-633 4.40e-03

DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type II DNA topoisomerase (DNA gyrase). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273417 [Multi-domain]  Cd Length: 488  Bit Score: 40.19  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAigANDAARPGRIDIDVGPAEGvpsplKQLSIAVRDNGPGIPPDTMPHLF-EPFFTTK--EIGQGL 623
Cdd:TIGR01052  29 LTTVIHELVTNSLDA--CEEAGILPDIKVEIEKIGK-----DHYKVTVEDNGPGIPEEYIPKVFgKMLAGSKfhRIIQSR 101

                          90
                  ....*....|.
gi 2539247726 624 GL-GLAISTSI 633
Cdd:TIGR01052 102 GQqGIGISGAV 112
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 547-629 4.85e-03

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 38.87  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIganDAAR--PgriDIDVGPAEGVPSPLKqlsIAVRDNGPGIPPDTMPHLF-EPFFTTKEIG--- 620
Cdd:cd16933    20 LYTTVRELVENSLDAT---EEAGilP---DIKVEIEEIGKDHYK---VIVEDNGPGIPEEQIPKVFgKVLYGSKYHNkqs 90

                          90
                  ....*....|..
gi 2539247726 621 ---QGLGLGLAI 629
Cdd:cd16933    91 rgqQGLGISAAV 102
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 554-610 5.72e-03

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 39.88  E-value: 5.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2539247726 554 LIGNALDAigANDAARPGRIDIDVgpaEGVPSPLKQLSIAVRDNGPGIPPDTMPHLF 610
Cdd:PRK04184   44 LVDNSLDA--CEEAGILPDIKIEI---KRVDEGKDHYRVTVEDNGPGIPPEEIPKVF 95
COG1389 COG1389
DNA topoisomerase VI, subunit B [Replication, recombination and repair];
554-610 5.91e-03

DNA topoisomerase VI, subunit B [Replication, recombination and repair];


Pssm-ID: 440999 [Multi-domain]  Cd Length: 530  Bit Score: 39.81  E-value: 5.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 554 LIGNALDAIganDAAR--PgRIDIDVGPAEGvpsplKQL-SIAVRDNGPGIPPDTMPHLF 610
Cdd:COG1389    43 AVDNSLDAC---EEAGilP-DIKVSIERVDG-----KDIyRVTVEDNGPGIPPEQIPKVF 93
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
539-661 6.07e-03

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 39.76  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 539 LVRADELKLEQVLINLIGNALDAIGANDAarpgrIDIDVGPAEgvpsplKQLSIAVRDNGPGIPPDTMPHLFEPFF---- 614
Cdd:PRK09835  368 QVAGDPLMLRRAISNLLSNALRYTPAGEA-----ITVRCQEVD------HQVQLVVENPGTPIAPEHLPRLFDRFYrvdp 436

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2539247726 615 TTKEIGQGLGLGLAISTSIARDFGGSLSAINMPDgGAQFTLTLVRAE 661
Cdd:PRK09835  437 SRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLPRLE 482
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 547-644 6.78e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 36.60  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 547 LEQVLINLIGNALDAIGANdaarpGRIDIDVGPAEGVpsplkqLSIAVRDNGPGIPPDTMPHLFEPFF---TTKEIGqGL 623
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPEN-----TRIYITSFLTDDV------VNIMFKNPSSHPLDFKLEKLFERFYrgdNSRNTE-GA 68

                          90       100
                  ....*....|....*....|.
gi 2539247726 624 GLGLAISTSIARDFGGSLSAI 644
Cdd:cd16923    69 GLGLSIAKAIIELHGGSASAE 89
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 569-664 8.91e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 39.12  E-value: 8.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539247726 569 RPGRIDIDVGPAEGvpsplkQLSIAVRDNGPGIPPDTmphlfepffttkEIGQGLGLGLAISTSIARDFGGSLSAINmpD 648
Cdd:COG3920   420 EGGRIRVSWRREDG------RLRLTVSDNGVGLPEDV------------DPPARKGLGLRLIRALVRQLGGTLELDR--P 479

                          90
                  ....*....|....*.
gi 2539247726 649 GGAQFTLTLVRAEVTS 664
Cdd:COG3920   480 EGTRVRITFPLAELAA 495
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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