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Conserved domains on  [gi|2539731967|ref|WP_295943127|]
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DUF938 domain-containing protein [uncultured Acidovorax sp.]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 7-207 1.04e-79

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam06080:

Pssm-ID: 473071  Cd Length: 201  Bit Score: 236.58  E-value: 1.04e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967   7 QHSPAAERNQGPILAQLLALLPSSGAA-LEIASGTGQHAAHFAAALPGWTWQPTDLQDTHFGSITGWAAQAGARNVQAPR 85
Cdd:pfam06080   2 PFAPAAERNREPILSVLQSYFAKTTERvLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  86 RLDVLHDRWPSEGPAfgAASFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLVTYGPYLEDGTPTAPGNLAFDASLR 165
Cdd:pfam06080  82 HLDVTRPPWPVEAPA--PASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLR 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2539731967 166 AQDAAWGIRRIEDVTAVAAHAGLQLAARHAMPANNLLLVWTH 207
Cdd:pfam06080 160 QRDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 7-207 1.04e-79

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 236.58  E-value: 1.04e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967   7 QHSPAAERNQGPILAQLLALLPSSGAA-LEIASGTGQHAAHFAAALPGWTWQPTDLQDTHFGSITGWAAQAGARNVQAPR 85
Cdd:pfam06080   2 PFAPAAERNREPILSVLQSYFAKTTERvLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  86 RLDVLHDRWPSEGPAfgAASFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLVTYGPYLEDGTPTAPGNLAFDASLR 165
Cdd:pfam06080  82 HLDVTRPPWPVEAPA--PASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLR 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2539731967 166 AQDAAWGIRRIEDVTAVAAHAGLQLAARHAMPANNLLLVWTH 207
Cdd:pfam06080 160 QRDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-199 2.97e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  18 PILAQLLALLPSSGAALEIASGTGQHAAHFAAALpGWTWQPTDLQDTHFGSITGWAAQAGARNVqaprrlDVLHDRWpSE 97
Cdd:COG0500    15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGLGNV------EFLVADL-AE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  98 GPAFGAASFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLV----TYGPYLEDGTPTAPGNLAFDASLRAQDAAWGI 173
Cdd:COG0500    87 LDPLPAESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLlsasDAAAALSLARLLLLATASLLELLLLLRLLALE 166

                         170       180
                  ....*....|....*....|....*.
gi 2539731967 174 RRIEDVTAVAAHAGLQLAARHAMPAN 199
Cdd:COG0500   167 LYLRALLAAAATEDLRSDALLESANA 192
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 7-207 1.04e-79

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 236.58  E-value: 1.04e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967   7 QHSPAAERNQGPILAQLLALLPSSGAA-LEIASGTGQHAAHFAAALPGWTWQPTDLQDTHFGSITGWAAQAGARNVQAPR 85
Cdd:pfam06080   2 PFAPAAERNREPILSVLQSYFAKTTERvLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  86 RLDVLHDRWPSEGPAfgAASFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLVTYGPYLEDGTPTAPGNLAFDASLR 165
Cdd:pfam06080  82 HLDVTRPPWPVEAPA--PASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGGVLYIYGPYNQDGELTSDSNRDFDRSLR 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2539731967 166 AQDAAWGIRRIEDVTAVAAHAGLQLAARHAMPANNLLLVWTH 207
Cdd:pfam06080 160 QRDPEWGIRDIEDVIALAAAQGLQLVKDVDMPANNRCLIFQK 201
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-199 2.97e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  18 PILAQLLALLPSSGAALEIASGTGQHAAHFAAALpGWTWQPTDLQDTHFGSITGWAAQAGARNVqaprrlDVLHDRWpSE 97
Cdd:COG0500    15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGLGNV------EFLVADL-AE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  98 GPAFGAASFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLV----TYGPYLEDGTPTAPGNLAFDASLRAQDAAWGI 173
Cdd:COG0500    87 LDPLPAESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLlsasDAAAALSLARLLLLATASLLELLLLLRLLALE 166

                         170       180
                  ....*....|....*....|....*.
gi 2539731967 174 RRIEDVTAVAAHAGLQLAARHAMPAN 199
Cdd:COG0500   167 LYLRALLAAAATEDLRSDALLESANA 192
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 20-141 3.19e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.40  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  20 LAQLLA-LLPSSGAALEIASGTGQHAAHFAAAlpGWtwqptdlqdthfgSITGW----AAQAGARNVQAPRRLDVLHDRW 94
Cdd:COG2227    14 LAALLArLLPAGGRVLDVGCGTGRLALALARR--GA-------------DVTGVdispEALEIARERAAELNVDFVQGDL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2539731967  95 psEGPAFGAASFDLVYCANML-HIAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:COG2227    79 --EDLPLEDGSFDLVICSEVLeHLPDPA---ALLRELARLLKPGGLLL 121
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 34-138 4.30e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.10  E-value: 4.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  34 LEIASGTGQHAAHFAAALpGWTWQPTDLQDTHfgsitgwAAQAGARNVQAPRRLDVLH---DRWPsegpaFGAASFDLVY 110
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-GARVTGVDLSPEM-------LERARERAAEAGLNVEFVQgdaEDLP-----FPDGSFDLVV 68

                          90       100
                  ....*....|....*....|....*...
gi 2539731967 111 CANMLHIAPWACCTGLMQGAAQHLAPGG 138
Cdd:pfam13649  69 SSGVLHHLPDPDLEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 20-145 8.69e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.15  E-value: 8.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  20 LAQLLALLPSSgAALEIASGTGQHAAHFAAALpGWTWQPTDLQDTHFGSITGWAAQAGARNVQAPRRLDVLHdrWPSEGP 99
Cdd:COG2230    43 ILRKLGLKPGM-RVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRD--LPADGQ 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2539731967 100 afgaasFDLVYCANMLHIAPWACCTGLMQGAAQHLAPGGRLVTYGP 145
Cdd:COG2230   119 ------FDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHTP 158
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 20-141 1.33e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.44  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  20 LAQLLALLPSSgAALEIASGTGQHAAHFAAalpgwtwqptdlqdtHFGSITG------WAAQAGARNVQAPRRLDVLHdr 93
Cdd:COG2226    14 LLAALGLRPGA-RVLDLGCGTGRLALALAE---------------RGARVTGvdispeMLELARERAAEAGLNVEFVV-- 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2539731967  94 WPSEGPAFGAASFDLVYCANMLH-IAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:COG2226    76 GDAEDLPFPDGSFDLVISSFVLHhLPDPE---RALAEIARVLKPGGRLV 121
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
19-141 2.80e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.06  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  19 ILAQLLALLPSSGA--ALEIASGTGQHAAHFAAalpgwtwqptdlqdtHFGSITG------WAAQAGARNVQAP-RRLDV 89
Cdd:COG4976    34 LAEELLARLPPGPFgrVLDLGCGTGLLGEALRP---------------RGYRLTGvdlseeMLAKAREKGVYDRlLVADL 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2539731967  90 LHDRWPSEgpafgaaSFDLVYCANML-HIAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:COG4976    99 ADLAEPDG-------RFDLIVAADVLtYLGDLA---AVFAGVARALKPGGLFI 141
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 34-140 3.46e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.20  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  34 LEIASGTGQHAAHFAAALPGWTWQPTDLQDThfgsitgwAAQAGARNVQAPRRLDVLHDRWPSEGPAFGA-ASFDLVYCA 112
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPA--------ALEAARERLAALGLLNAVRVELFQLDLGELDpGSFDVVVAS 72

                          90       100
                  ....*....|....*....|....*....
gi 2539731967 113 NML-HIAPWAcctGLMQGAAQHLAPGGRL 140
Cdd:pfam08242  73 NVLhHLADPR---AVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
31-141 1.28e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.81  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  31 GAALEIASGTGQHAAHFAAALPGWTwqptdlqdthfgsITGW--------AAQAGARNVQApRRLDVLHdrWPSEGPafg 102
Cdd:COG4106     3 RRVLDLGCGTGRLTALLAERFPGAR-------------VTGVdlspemlaRARARLPNVRF-VVADLRD--LDPPEP--- 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2539731967 103 aasFDLVYCANMLH-IAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:COG4106    64 ---FDLVVSNAALHwLPDHA---ALLARLAAALAPGGVLA 97
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 34-141 6.75e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.64  E-value: 6.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  34 LEIASGTGQHAAHFAAalpgwtwqptdlqdtHFGSITG---------WAAQAGARNVQAPRRLDVLHdrwpsegPAFGAA 104
Cdd:pfam08241   1 LDVGCGTGLLTELLAR---------------LGARVTGvdispemleLAREKAPREGLTFVVGDAED-------LPFPDN 58

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2539731967 105 SFDLVYCANML-HIAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:pfam08241  59 SFDLVLSSEVLhHVEDPE---RALREIARVLKPGGILI 93
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-141 3.92e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 36.64  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2539731967  19 ILAQLLALLPSSGAALEIASGTGqhaaHFAAALPGWTWQPTdlqdthfgSITGWAAQAGARNVQAPRRLDVLHDRWPSEG 98
Cdd:pfam13489  12 LLLRLLPKLPSPGRVLDFGCGTG----IFLRLLRAQGFSVT--------GVDPSPIAIERALLNVRFDQFDEQEAAVPAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2539731967  99 PafgaasFDLVYCANML-HIAPWAcctGLMQGAAQHLAPGGRLV 141
Cdd:pfam13489  80 K------FDVIVAREVLeHVPDPP---ALLRQIAALLKPGGLLL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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