|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-442 |
1.00e-101 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 310.16 E-value: 1.00e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 13 LFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFE 92
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 93 VTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLI 172
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 173 AAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQNAI 252
Cdd:cd13138 161 IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 253 FAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVLGG 332
Cdd:cd13138 241 VSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 333 ILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIWVFtIFAHYR 412
Cdd:cd13138 321 LVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAY-LLSRLT 399
|
410 420 430
....*....|....*....|....*....|..
gi 2540502296 413 --TVESLFLLYPFSWAATAVFEIVYFAIIYKK 442
Cdd:cd13138 400 glGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
8-435 |
3.79e-84 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 264.70 E-value: 3.79e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 8 MTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKN 87
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 88 YKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSP 167
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 168 LLYLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAG 247
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 248 LQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAG 327
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 328 FVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIWVFTI 407
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*...
gi 2540502296 408 FAHYRTVESLFLLYPFSWAATAVFEIVY 435
Cdd:COG0534 400 AFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
15-436 |
5.69e-63 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 209.68 E-value: 5.69e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVT 94
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRL-GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 95 VRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAA 174
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 175 GIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQN 250
Cdd:cd13137 160 NVLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 251 AIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVL 330
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 331 GGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVI--WVFTIF 408
Cdd:cd13137 320 GLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPlaYLLGFV 399
|
410 420
....*....|....*....|....*...
gi 2540502296 409 AHYrTVESLFLLYPFSWAATAVFEIVYF 436
Cdd:cd13137 400 LGL-GLTGIWLAMFVDTIVRAILLLYRF 426
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-390 |
1.70e-46 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 166.16 E-value: 1.70e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 11 GSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKD 90
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRL-GSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 91 FEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTK-PELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLL 169
Cdd:cd13140 80 ARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGdAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 170 YLIAAGIVNVFLDLLLVIVF----KLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVP 245
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 246 AGLQNAIFAIANLFIVAAVNSFDAAMVAgnAATMNG--DNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYA 323
Cdd:cd13140 240 VALQSILFALISMILARIIASFGPVAIA--AQKVGSqiESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIA 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2540502296 324 AIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSI 390
Cdd:cd13140 318 SAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAI 384
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-401 |
7.11e-44 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 159.28 E-value: 7.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 7 DMTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQK 86
Cdd:cd13142 3 NILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRL-GADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 87 NYKdfevtvRASAVACFCIGILLLVAGVFSATG-------ILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILS 159
Cdd:cd13142 82 DYD------KANKVAGQTFSFVIILSLILAVLGyilsrplLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 160 AQGDTRSPLLYLIAAGIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYK-----VLSKNNF--DFKY 228
Cdd:cd13142 156 GIGDTKTPMKIMFGSVLLNVILDPLLIfgigPFPGLGVAGAALATVISRGIAAVIGLYLLFKgrvglKISLRDLkpDWEW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 229 rqissykILQIIKIGVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHK 308
Cdd:cd13142 236 -------LKKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQ 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 309 KKRILSSYFISMGYAAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVP 388
Cdd:cd13142 309 IDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTA 388
|
410
....*....|...
gi 2540502296 389 SIMVFIGSCVLRV 401
Cdd:cd13142 389 MIISILRLWVIRI 401
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-436 |
2.29e-41 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 151.89 E-value: 2.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 12 SLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGST--GQMVFFCSGILTGLGGGVnvLAAICVGQKNYK 89
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVfpIIMLLMALGLMIGVGGAS--LISRRLGAGDRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 90 DFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLL 169
Cdd:cd13143 79 KANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 170 YLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQ 249
Cdd:cd13143 159 GMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 250 NAIFAIANLFIVAAVNSFD-AAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGF 328
Cdd:cd13143 239 QLSSSVVTIVLNLTLLGYGgDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 329 VLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIWVFtIF 408
Cdd:cd13143 319 VLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLL-IL 397
|
410 420
....*....|....*....|....*...
gi 2540502296 409 AHYRTVESLFLLYPFSWAATAVFEIVYF 436
Cdd:cd13143 398 PRLFGLDGIWLAFPLAEILTLLLALILL 425
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-436 |
5.13e-40 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 148.24 E-value: 5.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 21 SVPLVITNVLQILFNMTDTAVVGRFAGYLpLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVTVRASAV 100
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDA-LAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 101 ACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVF 180
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 181 LDLLLV---IVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQNAIFAIAN 257
Cdd:cd12082 160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 258 LFIVAAVNSFDAAM-VAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVLGGILFV 336
Cdd:cd12082 240 LIIVAIVAAFGGAAaLAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 337 FGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIWVFTIFAHYRTVES 416
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYG 399
|
410 420
....*....|....*....|
gi 2540502296 417 LFLLYPFSWAATAVFEIVYF 436
Cdd:cd12082 400 IWLALVISLILAALVLLLFF 419
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-357 |
8.09e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 148.03 E-value: 8.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVT 94
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRY-SDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 95 VRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAA 174
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 175 GIVNVFLDLLLVIVF----KLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQN 250
Cdd:cd13134 162 NILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 251 AIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVL 330
Cdd:cd13134 242 LSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAV 321
|
330 340
....*....|....*....|....*..
gi 2540502296 331 GGILFVFGQEFLSLFTKDQAVVGYAMQ 357
Cdd:cd13134 322 ALLLALFREPILGLFTDDPEIIALGKT 348
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
23-357 |
8.69e-40 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 145.85 E-value: 8.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 23 PLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVTVRASAVAC 102
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 103 FCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVFLD 182
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 183 LLLVIVF--KLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQNAIFAIANLFI 260
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 261 VAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVLGGILFVFGQE 340
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330
....*....|....*..
gi 2540502296 341 FLSLFTKDQAVVGYAMQ 357
Cdd:TIGR00797 320 IARLFTNDPEVLELAAI 336
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
13-394 |
2.18e-38 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 143.86 E-value: 2.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 13 LFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKD-F 91
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEaI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASAVACFcIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYL 171
Cdd:cd13136 81 ALLVRALLLALA-IGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 172 IAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVPAGLQNA 251
Cdd:cd13136 160 IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 252 IFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVLG 331
Cdd:cd13136 240 ALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2540502296 332 GILFVFGQEFLSLFTKDQAVVGYAMQ--KFKIMTFSFGISAFM-DGT---IAASRGLRKTLVPSIMVFI 394
Cdd:cd13136 320 LLFFLGGEPIIRLFTDDPAVLALAATylPWLALLPPIGALAFVlDGIfigATDTRYLRNSMLVSLAVFL 388
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-401 |
2.08e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 135.89 E-value: 2.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 8 MTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKN 87
Cdd:cd13149 2 LTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKL-GTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 88 YKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSP 167
Cdd:cd13149 81 RNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 168 LLYLIAAGIVNVFLDLLLVIVF----KLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIG 243
Cdd:cd13149 161 SLVMLGAALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 244 VPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYA 323
Cdd:cd13149 241 IPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFS 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2540502296 324 AIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRV 401
Cdd:cd13149 321 LIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYI 398
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-436 |
2.88e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 129.95 E-value: 2.88e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVT 94
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 95 VRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAA 174
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 175 GIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNF-DFKYRQISSYKILQIIKIGVPAGLQ 249
Cdd:cd13133 164 VVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFgLRRAWRFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 250 NAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFV 329
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 330 LGGILFVFGQEFLSLFTKD---QAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIWVFT 406
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|
gi 2540502296 407 IFAHYRTVESLFLLYPFSWAATAVFEIVYF 436
Cdd:cd13133 404 LVVLGAGLAGAWTVETVYVIVLALIFLLRF 433
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
14-395 |
5.25e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 129.16 E-value: 5.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 14 FKKIFIFSVPLVITNVLQILFNMTDTAVVGRfAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEV 93
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 94 TVRASAVACFCIGILLLVAgVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIA 173
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLL-LWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 174 AGIVNVFLDLLLVI----VFKLSVVGVGVATVIAQYISCILTLRKIY--KVLSKNNFDFKYRQISSYKILQIIKIGVPAG 247
Cdd:cd13131 160 ALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRrhKRFRRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 248 LqnAIFAIANLFIVAAV--NSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAI 325
Cdd:cd13131 240 L--TIFFEVSLFAAVALlmGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVG 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2540502296 326 AGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQkFKIMTFSFGISAFMDGTIA-ASRGLRKTLVPSIMVFIG 395
Cdd:cd13131 318 FAALTALLLLLFPEQIAGLYTNDPAVIALAAS-LLVFAALFQLFDGIQVVAAgALRGYKDTRVPFLLALIS 387
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-439 |
1.73e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 125.04 E-value: 1.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 8 MTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKN 87
Cdd:cd13144 1 MGSGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARL-GENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 88 YKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSP 167
Cdd:cd13144 80 QKEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 168 LLYLIAAGIVNVFLDLLLVIVF----KLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIG 243
Cdd:cd13144 160 MIAQLIGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 244 VPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYA 323
Cdd:cd13144 240 LPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 324 AIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGSCVLRVIW 403
Cdd:cd13144 320 VVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 2540502296 404 VFtIFAHYRTVESLFLLYPFSWAATAVFEIVYFAII 439
Cdd:cd13144 400 AW-LLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKRL 434
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-431 |
8.94e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 123.11 E-value: 8.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 5 EMDMTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVG 84
Cdd:cd13139 4 EQDFTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRL-GALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 85 QKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDT 164
Cdd:cd13139 83 EKDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 165 RSPLLYLIAAGIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQII 240
Cdd:cd13139 163 AIAMRSLWLANGLNIILDPLFIfglgPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKII 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 241 KIGVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGnaATMNGDNLVFNIMSAF--YTAGATFIGQNLGAHKKKRILSSYFI 318
Cdd:cd13139 243 KIAVGGILQFLIASSSWIFLVRIIAEFGSTALAG--YTIAIRIIMFALLPAWglSNAAATLVGQNLGAGQPDRAEKSVWR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 319 SMGYAAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGScv 398
Cdd:cd13139 321 AGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGF-- 398
|
410 420 430
....*....|....*....|....*....|...
gi 2540502296 399 lrviWVFTIFAHYrtveslFLLYPFSWAATAVF 431
Cdd:cd13139 399 ----WLFQIPLAY------LLARHLNLGPKGVF 421
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-355 |
3.32e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 112.77 E-value: 3.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLpLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVT 94
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRY-YSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 95 VRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAA 174
Cdd:cd13135 80 AISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 175 GIVNVFLDLLLVI----VFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKN----NFDFKYRQISSYKilQIIKIGVPA 246
Cdd:cd13135 160 NLLNVILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTfklsNTKVLKANIRPYK--FTIKLGLPL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 247 GLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIA 326
Cdd:cd13135 238 GGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLI 317
|
330 340
....*....|....*....|....*....
gi 2540502296 327 GFVLGGILFVFGQEFLSLFTKDQAVVGYA 355
Cdd:cd13135 318 YIAAAIVFLAFPYKILSLFTNDPELINYS 346
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
14-382 |
6.04e-26 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 109.20 E-value: 6.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 14 FKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAG-YLPLGSVGSTGQMVFfCSGILTGLGGGVNVLAAICVGQKNYKDFE 92
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKlELAAASLASSFANVT-GFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 93 VTVRASAV----ACFCIGILLLVAGvfsatGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPL 168
Cdd:cd13132 81 VYLQRALVilllCCVPISLLWLNTE-----PILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 169 LYLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLrkIYKVLSKNNFDFKY--RQISSYKILQIIKIGVPA 246
Cdd:cd13132 156 YISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLL--LYIFFSKGHKATWGgfSREAFRGWGPFLKLAIPS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 247 GLQNAIFAIANLFIVAAVNSFDA-AMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAI 325
Cdd:cd13132 234 ALMLCLEWWAFEILVLLAGLLPGtVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2540502296 326 AGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMtfsfGISAFMDGTIAASRGL 382
Cdd:cd13132 314 IGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPIL----ALFQIFDGLQAVLSGV 366
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-440 |
7.86e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 108.84 E-value: 7.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 7 DMTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAvvgrFAGYLPLGSVG--STGQMVFFCS-GILTGLGGGVNVLAAICV 83
Cdd:cd13145 1 DLTKGPIPKLIRKLAIPASVGFFFNTMFNVVDTF----FAGKISTEALAalSLSFPIFFIIiAIGVGIGTGTTALIGNAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 84 GQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGD 163
Cdd:cd13145 77 GAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 164 TRSPLLYLIAAGIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYKvlSKNNFDFKYR----QISSYK 235
Cdd:cd13145 157 TKSYRNFLIIGFFLNIILDPLFIfgggGIPAMGVSGIALATIISQFIGMFYLLYKVRK--SGIISGCRLRdfipRLDVYK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 236 ilQIIKIGVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSS 315
Cdd:cd13145 235 --EILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRET 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 316 YFISMGYAAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPsIMVFIG 395
Cdd:cd13145 313 YKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFA-LWIGLY 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2540502296 396 SCVLRVIWVFTIFAHYRTVESLFLLYpfswaatAVFEIVYFAIIY 440
Cdd:cd13145 392 RQLVGPALVFWLLVNVLGLGVTGIWW-------GIFTIVWSAAII 429
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-402 |
6.04e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 100.55 E-value: 6.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 8 MTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLP--LGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQ 85
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 86 KNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTR 165
Cdd:cd13146 81 QRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 166 SPLLYLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKIGVP 245
Cdd:cd13146 161 YMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 246 AGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFIS--MGYA 323
Cdd:cd13146 241 QMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAviLGIV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 324 AIAGFVLGGILfvFGQEFLSLFTKDQAVVGYAMQKFKIM-------TFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGS 396
Cdd:cd13146 321 VVLVLVLGYVL--VAPWLFSLFTTVPEVVAYAVLQVRTMalalpfvAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPV 398
|
....*.
gi 2540502296 397 CVLRVI 402
Cdd:cd13146 399 VYLLAY 404
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-366 |
8.08e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 100.08 E-value: 8.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 7 DMTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQK 86
Cdd:cd13141 3 DLTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQL-GDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 87 NYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRS 166
Cdd:cd13141 82 DQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 167 PLLYLIAAGIVNVFLDLLLV----IVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKILQIIKI 242
Cdd:cd13141 162 FMVIQILAVLLNIILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRLLKI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 243 GVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGY 322
Cdd:cd13141 242 GLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAIL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2540502296 323 AAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSF 366
Cdd:cd13141 322 TTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNF 365
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
21-346 |
1.89e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 87.21 E-value: 1.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 21 SVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVTVRASAV 100
Cdd:cd13147 15 SIPMIIAMLLQTLYNLVDAIWVAGL-GADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 101 ACFCIGILLLVAGVFSATGILNLLNTKpELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVF 180
Cdd:cd13147 94 LGLIISIILTIVLLPFLEPILVLMGAG-EVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNII 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 181 LDLLLVIVFKLSVVGVGVATVIAQYISCILTlrkIYKVLSKN----NFDFKYRQISSYKILQIIKIGVPAGLQNAIFAIA 256
Cdd:cd13147 173 LDPIFIYTLGLGIAGAAWATVISMLISSLVL---LYWFFVKKdtyvSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 257 NLFI-VAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAAIAGFVLGGILF 335
Cdd:cd13147 250 MIILnLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIF 329
|
330
....*....|.
gi 2540502296 336 VFGQEFLSLFT 346
Cdd:cd13147 330 IFAPQIAYLFT 340
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
23-184 |
1.66e-16 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 76.45 E-value: 1.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 23 PLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVTVRASAVAC 102
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL-GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 103 FCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVFLD 182
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 2540502296 183 LL 184
Cdd:pfam01554 160 YL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
15-357 |
2.89e-16 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 80.63 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRF-AGYLPLGSVGSTGQM--VFFCSGILTGLgggvNVLAAICVGQKNYKDF 91
Cdd:PRK01766 12 RQLLALALPILLAQVAQTAMGFVDTVMAGGVsATDLAAVAIGTSIWLpvILFGHGLLLAL----TPIVAQLNGAGRRERI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYL 171
Cdd:PRK01766 88 AHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 172 IAAGIVNVFLDLLLVI----VFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDF--KYRQISSYKILQIIKIGVP 245
Cdd:PRK01766 168 FLGLLINIPLNYIFIYgkfgFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLfkGLYKPDWAVIKRLLKLGLP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 246 AGLqnAIFAIANLFIVAA--VNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYA 323
Cdd:PRK01766 248 IGL--AIFFEVSLFAVVTllVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVG 325
|
330 340 350
....*....|....*....|....*....|....
gi 2540502296 324 AIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQ 357
Cdd:PRK01766 326 LGMALLTAIFLVLFREQIALLYTDDPEVVALASH 359
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-361 |
5.40e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 73.46 E-value: 5.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 8 MTQGSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRfagylpLGSVGSTGQMVFFCSGILT------GLGGGVNVLAAI 81
Cdd:cd13148 5 LLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQ------LGTDALAGVALVFPLLMLTqmmsngAMGGGVSSAIAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 82 CVGQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQ 161
Cdd:cd13148 79 ALGAGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 162 GDTRSPLLYLIAAGIVNVFLDLLLVI----VFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKIL 237
Cdd:cd13148 159 GNMRVPALVTLVGAVVQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 238 QIIKIGVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYF 317
Cdd:cd13148 239 DILRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAW 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2540502296 318 ISMGYAAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKI 361
Cdd:cd13148 319 TGALMAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRI 362
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
245-396 |
4.93e-11 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 61.04 E-value: 4.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 245 PAGLQNAIFAIANLFIVAAVNSFDAAMVAGNAATMNGDNLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISMGYAA 324
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2540502296 325 IAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMTFSFGISAFMDGTIAASRGLRKTLVPSIMVFIGS 396
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-213 |
1.05e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 60.22 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 12 SLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDF 91
Cdd:cd13137 223 KIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASY-GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASA-VACFCIGILLLVAGVFsATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLL- 169
Cdd:cd13137 302 RRYGKRALrLGVLFMGLLGLLLFIF-APPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIi 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2540502296 170 YLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLR 213
Cdd:cd13137 381 NLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLY 424
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
3-377 |
5.42e-08 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 55.00 E-value: 5.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 3 SIEMDMTQgSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAIC 82
Cdd:PRK09575 1 SITIMMNQ-SIYRTFWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 83 VGQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYM------LCMPAMAMYnfgna 156
Cdd:PRK09575 80 RGEGDLEKAKRILTTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIwgclftLGAIALPFL----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 157 ILSAQGDTRSPLLYLIAAgIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDFKYRQISSYKI 236
Cdd:PRK09575 155 LRNDESPNLATGLMVIGA-LINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 237 LQIIKIGVPAGLQNAIFAianlFIVAAVNSFdaAMVAGNAATMNGDNLVFNIMSAFYTAgATFIGQ--------NLGAHK 308
Cdd:PRK09575 234 PKIVLLGSSSFFMYLYGS----FVVALHNRL--FMEYGSALTVGAYAIVGYLMVLYYLV-AEGIAEgmqppvsyYFGARQ 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 309 KKRILSSYFISMGYAAIAGFVLGGILFVFGQEFLSLFTK-DQAVVGYAMQKFKIMTFSFgisaFMDGTIA 377
Cdd:PRK09575 307 YDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALFNSgDSELIAETIVGIRLHLFAM----FLDGFLV 372
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
17-212 |
9.20e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 53.80 E-value: 9.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 17 IFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDFEVTVR 96
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 97 ASAVACFCIGILLLVAGVFSATGILNLLNTKPelLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGI 176
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*.
gi 2540502296 177 VNVFLDLLLVIVFklSVVGVGVATVIAQYISCILTL 212
Cdd:COG2244 333 LNLVLNLLLIPRY--GLVGAAIATLLSYLVLLLLLL 366
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
74-275 |
1.64e-07 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 53.20 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 74 GVNVLAAICVGQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLL--NTKPELLHDAAVYFKIYMLCMPAMAMY 151
Cdd:PRK10189 87 GTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVagDATPEVKALALTYLELTVWSYPAAAIT 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 152 NFGNAILSAQGDTRSPLLYLIAAGIVNVFLDLLLVI-VFK---LSVVGVGVATVIAQYI---SCILTLRKIYKVLSKNNF 224
Cdd:PRK10189 167 LIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYgLFSwqgLGFVGAGLGLTISRYIgavAIIWVLMIGFNPALRISL 246
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2540502296 225 DFKYRQISSYKILQIIKIGVPAGLQNAIFAIANLFIVAAVNSFDAAMVAGN 275
Cdd:PRK10189 247 KSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGN 297
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
12-216 |
3.63e-07 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 52.16 E-value: 3.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 12 SLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVnVLAAICVGQKNYKDF 91
Cdd:cd13128 203 KLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTAL-FPRISELYKNDKDEL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASAVACFCIGILLLVAGVFSATGILNLLNTkpELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYL 171
Cdd:cd13128 282 KKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFG--EEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKIL 359
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2540502296 172 IAAGIVNVFLDLLLviVFKLSVVGVGVATVIAQYISCILTLRKIY 216
Cdd:cd13128 360 LIGALLNVILNLLL--IPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
15-219 |
3.77e-07 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 52.05 E-value: 3.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 15 KKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKdfevt 94
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQ----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 95 vrASAVACFCIGILLLVAGVFSATG-------ILNLLNTKPELLHDAAVYFKIYMLCMPA-MAMYNFGNAILSAQGdTRS 166
Cdd:PRK10367 84 --ALARALVQPLLLALGAGALIALLrtplidlALHIVGGSEAVLEQARRFLEIRWLSAPAsLANLVLLGWLLGVQY-ARA 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2540502296 167 PLLYLIAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVL 219
Cdd:PRK10367 161 PVILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVL 213
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
11-219 |
1.93e-06 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 49.77 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 11 GSLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFagyLPLGSVGSTGQMVFFcsGILTGLGG-----GVNVLAAICV-- 83
Cdd:cd13124 220 KEILKELLSYAIPITLSSLILPLLQLIDSFTVPRR---LQAAGLSESEATALY--GILTGRAQplvqlPTVIATALSTsl 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 84 --------GQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPEllhdAAVYFKIYMLCMPAMAMYNFGN 155
Cdd:cd13124 295 vpaiseayAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTA 370
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2540502296 156 AILSAQGDTRSPLLYLIAAGIVNVFLDLLLVIVFKlsVVGVGVATVIAQYISCILTLRKIYKVL 219
Cdd:cd13124 371 AILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFG--IYGAAIATVIGFLVAALLNLRALKKLL 432
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
12-212 |
5.32e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 48.47 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 12 SLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDF 91
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYL 171
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2540502296 172 IAAGIVNVFLDLLLVIVFKLSVVGVGVATVIAQYISCILTL 212
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-196 |
1.69e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 46.73 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 12 SLFKKIFIFSVPLVITNVLQILFNMTDTAVVGRFaGYLPLGSVGSTGQMVFFCSGILTGLGGGVNVLAAICVGQKNYKDF 91
Cdd:cd13134 225 KLLKKILKIGLPSAGEELSYNLSQTVITAFIARL-GTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEA 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 92 EVTVRASAVACFCIGILLLVAGVFSATGILNLLNTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLY- 170
Cdd:cd13134 304 YKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIg 383
|
170 180
....*....|....*....|....*.
gi 2540502296 171 LIAAGIVNVFLDLLLVIVFKLSVVGV 196
Cdd:cd13134 384 IISMWGISVPLAYLLGIVLGLGLLGV 409
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
14-226 |
3.57e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 45.94 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 14 FKKIFIFSVPLVITNVLQILFNMTDTAVVGRFAGYLPLGSVGSTGQMVFFCSGILTGLGGGVnVLAAICVGQKNYKDF-E 92
Cdd:cd13127 198 LKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSRAYRLALLPVQNITGPITRV-LFPALSRLQDDPERLrR 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 93 VTVRASAVACFCIGILLLVAGVFSATGILNLLNTKpelLHDAAVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLI 172
Cdd:cd13127 277 AYLKALRLLALITFPLMVGLALLAEPLVLLLLGEK---WLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGL 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2540502296 173 AAGIVNVfldLLLVIVFKLSVVGVGVATVIAQYISCILTLRKIYKVLSKNNFDF 226
Cdd:cd13127 354 IKAVLTV---LALLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISLLEL 404
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
135-217 |
4.23e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 45.52 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 135 AVYFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVFLDLLLviVFKLSVVGVGVATVIAQYISCILTLRK 214
Cdd:cd13123 339 ASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLL--IKPLGHVGLALATSLSAWVNALLLLVL 416
|
...
gi 2540502296 215 IYK 217
Cdd:cd13123 417 LRR 419
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
137-219 |
6.82e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 42.56 E-value: 6.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 137 YFKIYMLCMPAMAMYNFGNAILSAQGDTRSPLLYLIAAGIVNVFLDLLLVIVFklSVVGVGVATVIAQYISCILTLRKIY 216
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLF--GIVGAAIATVISLLVVALLNLYYLR 78
|
...
gi 2540502296 217 KVL 219
Cdd:pfam14667 79 RYL 81
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
83-217 |
1.16e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 44.37 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 83 VGQKNYKDFEVTVRASAVACFCIGILLLVAGVFSATGILNLL----NTKPELLHDAAVYFKIYMLCMPAMAMYNFGNAIL 158
Cdd:COG0728 290 AAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLfergAFTAEDTALTALALAAYALGLPAFALVKVLARAF 369
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2540502296 159 SAQGDTRSPLLYLIAAGIVNVFLDLLLVIVFKlsVVGVGVATVIAQYISCILTLRKIYK 217
Cdd:COG0728 370 YARQDTRTPVRIAVIAVVVNIVLNLLLVPPLG--HAGLALATSLSALVNALLLLVLLRR 426
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
245-396 |
9.34e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 37.99 E-value: 9.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540502296 245 PAGLQNAIFAIANL---FIVAAVNSFDAAMVA-GNAATMngdnLVFNIMSAFYTAGATFIGQNLGAHKKKRILSSYFISM 320
Cdd:TIGR00797 1 PAILANILQPLLGLvdtAFVGHLGPVDLAAVSlGSSVFM----FLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSL 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2540502296 321 GYAAIAGFVLGGILFVFGQEFLSLFTKDQAVVGYAMQKFKIMtfSFGISAFMDGTIAAS--RGLRKTLVPSIMVFIGS 396
Cdd:TIGR00797 77 LLALLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRIL--ILGIPAYLLNFVLRGflRGQGDTKTPMYITLIGN 152
|
|
| |
