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Conserved domains on  [gi|2540601057|ref|WP_296761342|]
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flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [Varibaculum sp.]

Protein Classification

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase( domain architecture ID 10011395)

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, part of an alternative non-mevalonate pathway for isoprenoid biosynthesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-361 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


:

Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 613.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  10 PRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADI 89
Cdd:PRK00366    8 PRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLPVPLVADI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  90 HFQPKYVFAAIEGGCAGVRVNPGNIRKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEAR 169
Cdd:PRK00366   88 HFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVESALRHAK 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 170 LFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVE 249
Cdd:PRK00366  168 ILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVSLTADPVE 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 250 EIKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNG 329
Cdd:PRK00366  248 EVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEH-IKMPLKVAVMGCVVNGPGEAKEADIGIAGGNP 326
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLIAEAHRQAE 361
Cdd:PRK00366  327 KGPVFVDGEKIKTLPEENIVEELEAEIEAYAE 358
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-361 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 613.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  10 PRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADI 89
Cdd:PRK00366    8 PRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLPVPLVADI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  90 HFQPKYVFAAIEGGCAGVRVNPGNIRKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEAR 169
Cdd:PRK00366   88 HFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVESALRHAK 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 170 LFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVE 249
Cdd:PRK00366  168 ILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVSLTADPVE 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 250 EIKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNG 329
Cdd:PRK00366  248 EVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEH-IKMPLKVAVMGCVVNGPGEAKEADIGIAGGNP 326
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLIAEAHRQAE 361
Cdd:PRK00366  327 KGPVFVDGEKIKTLPEENIVEELEAEIEAYAE 358
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
10-361 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 588.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  10 PRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADI 89
Cdd:COG0821     7 PRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPLVADI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  90 HFQPKYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEAR 169
Cdd:COG0821    87 HFDYRLALEAAEAGVDKLRINPGNI-GSDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESALEHAR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 170 LFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVE 249
Cdd:COG0821   166 ILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTADPVE 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 250 EIKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNG 329
Cdd:COG0821   246 EVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRD-IKEPLKVAVMGCVVNGPGEAKEADIGIAGGGG 324
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLIAEAHRQAE 361
Cdd:COG0821   325 EGLLFKKGEIIRKVPEDEIVEELLEEIEKYVA 356
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
14-355 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 565.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  14 TRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADIHFQP 93
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  94 KYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEARLFEQ 173
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNI-GSEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 174 YDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVEEIKV 253
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 254 GIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNGKGKI 333
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEH-LKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGEGLL 318
                         330       340
                  ....*....|....*....|..
gi 2540601057 334 FIKGKVIKTVPEEEIVPTLIAE 355
Cdd:pfam04551 319 FKKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
11-353 2.62e-151

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 430.69  E-value: 2.62e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  11 RKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADIH 90
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  91 FQPKYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEARL 170
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNI-GFEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 171 FEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVEE 250
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 251 IKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKdEIKVPLRVAVMGCVVNGPGEAREADLG-VASGNG 329
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALS-HLKTPLKVAVMGCVVNGPGEAKHADIGiSGPGTG 318
                         330       340
                  ....*....|....*....|....
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLI 353
Cdd:TIGR00612 319 FAWLFKHGKPKAKVPETDMVDELI 342
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-361 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 613.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  10 PRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADI 89
Cdd:PRK00366    8 PRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLPVPLVADI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  90 HFQPKYVFAAIEGGCAGVRVNPGNIRKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEAR 169
Cdd:PRK00366   88 HFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVESALRHAK 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 170 LFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVE 249
Cdd:PRK00366  168 ILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVSLTADPVE 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 250 EIKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNG 329
Cdd:PRK00366  248 EVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEH-IKMPLKVAVMGCVVNGPGEAKEADIGIAGGNP 326
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLIAEAHRQAE 361
Cdd:PRK00366  327 KGPVFVDGEKIKTLPEENIVEELEAEIEAYAE 358
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
10-361 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 588.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  10 PRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADI 89
Cdd:COG0821     7 PRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPLVADI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  90 HFQPKYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEAR 169
Cdd:COG0821    87 HFDYRLALEAAEAGVDKLRINPGNI-GSDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESALEHAR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 170 LFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVE 249
Cdd:COG0821   166 ILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTADPVE 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 250 EIKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNG 329
Cdd:COG0821   246 EVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRD-IKEPLKVAVMGCVVNGPGEAKEADIGIAGGGG 324
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLIAEAHRQAE 361
Cdd:COG0821   325 EGLLFKKGEIIRKVPEDEIVEELLEEIEKYVA 356
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
14-355 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 565.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  14 TRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADIHFQP 93
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  94 KYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEARLFEQ 173
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNI-GSEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 174 YDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVEEIKV 253
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 254 GIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKDeIKVPLRVAVMGCVVNGPGEAREADLGVASGNGKGKI 333
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEH-LKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGEGLL 318
                         330       340
                  ....*....|....*....|..
gi 2540601057 334 FIKGKVIKTVPEEEIVPTLIAE 355
Cdd:pfam04551 319 FKKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
11-353 2.62e-151

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 430.69  E-value: 2.62e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  11 RKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVIAQKSTIPVVADIH 90
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  91 FQPKYVFAAIEGGCAGVRVNPGNIrKFDDQVEEITKCARKHGTALRIGINAGSLDPRVMARHGKATPEALAESAVNEARL 170
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNI-GFEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 171 FEQYDFHDFAISVKHHDPVTMIRAYELLSEMGDWPLHLGVTEAGPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVEE 250
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 251 IKVGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKLANAVTDALKdEIKVPLRVAVMGCVVNGPGEAREADLG-VASGNG 329
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALS-HLKTPLKVAVMGCVVNGPGEAKHADIGiSGPGTG 318
                         330       340
                  ....*....|....*....|....
gi 2540601057 330 KGKIFIKGKVIKTVPEEEIVPTLI 353
Cdd:TIGR00612 319 FAWLFKHGKPKAKVPETDMVDELI 342
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
11-251 6.05e-63

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 214.24  E-value: 6.05e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  11 RKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVI----AQKS-TIPV 85
Cdd:PLN02925   77 RRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIkntlVQKGyNIPL 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  86 VADIHFQPKYVFAAIEggC-AGVRVNPGNI----RKFDD-------------QVEEI-----TKCaRKHGTALRIGINAG 142
Cdd:PLN02925  157 VADIHFAPSVALRVAE--CfDKIRVNPGNFadrrAQFEKleyteddyqkeleHIEEVftplvEKC-KKYGRAMRIGTNHG 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 143 SLDPRVMARHGKaTPEALAESAVNEARLFEQYDFHDFAISVKHHDPVTMIRAYELL-SEM----GDWPLHLGVTEAGPAF 217
Cdd:PLN02925  234 SLSDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLvAEMyvlgWDYPLHLGVTEAGEGE 312
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2540601057 218 QGTIKSATAFGALLRQGIGDTIRVSLSADPVEEI 251
Cdd:PLN02925  313 DGRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 346
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
8-253 5.18e-61

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 206.61  E-value: 5.18e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057   8 GFPRKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALPVI-----AQKST 82
Cdd:PRK02048    5 NYSRRKTSVVNIGATPLGGPNPIRIQSMTNTSTMDTEACVAQAKRIIDAGGEYVRLTTQGVREAENLMNIniglrSQGYM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  83 IPVVADIHFQPKYVFAAIeGGCAGVRVNPGN---------------------IRKFDDQVEEITKCARKHGTALRIGINA 141
Cdd:PRK02048   85 VPLVADVHFNPKVADVAA-QYAEKVRINPGNyvdpgrtfkkleytdeeyaqeIQKIRDRFVPFLNICKENHTAIRIGVNH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 142 GSLDPRVMARHGKaTPEALAESAVNEARLFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGD-----WPLHLGVTEAGPA 216
Cdd:PRK02048  164 GSLSDRIMSRYGD-TPEGMVESCMEFLRICVEEHFTDVVISIKASNTVVMVRTVRLLVAVMEaegmhYPLHLGVTEAGDG 242
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2540601057 217 FQGTIKSATAFGALLRQGIGDTIRVSLSADPVEEIKV 253
Cdd:PRK02048  243 EDGRIKSAVGIGALLADGIGDTIRVSLSEEPEAEIPV 279
PRK00694 PRK00694
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
11-259 1.61e-60

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated


Pssm-ID: 234812  Cd Length: 606  Bit Score: 205.46  E-value: 1.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  11 RKKTRKIRCGNVEIGGDAPISVQSMCTTKTTDIGATLQQIAALTAAGCDIVRVACPSADDAEALP-----VIAQKSTIPV 85
Cdd:PRK00694   12 RRKTHPVRIGNLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLKEAQACEhikerLIQQGISIPL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057  86 VADIHFQPKyvfAAIE-GGCAG-VRVNPGNI-------------------------RKFDDQVEeitKCARKhGTALRIG 138
Cdd:PRK00694   92 VADIHFFPQ---AAMHvADFVDkVRINPGNYvdkrnmftgkiytdeqyahsllrleEKFSPLVE---KCKRL-GKAMRIG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 139 INAGSLDPRVMARHGKaTPEALAESAVNEARLFEQYDFHDFAISVKHHDPVTMIRAYELLSEMGD-----WPLHLGVTEA 213
Cdd:PRK00694  165 VNHGSLSERVMQRYGD-TIEGMVYSALEYIEVCEKLDYRDVVFSMKSSNPKVMVAAYRQLAKDLDargwlYPLHLGVTEA 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2540601057 214 GPAFQGTIKSATAFGALLRQGIGDTIRVSLSADPVEEIKVGIEILQ 259
Cdd:PRK00694  244 GSGTDGIIKSAVGIGTLLSEGLGDTIRCSLTGCPTNEIPVCISLLK 289
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
221-354 6.78e-20

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 91.43  E-value: 6.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 221 IKSATAFGALLRQGIGDTIRV----SLSADPVEEIKVGIeiLQSMGLKERTLEIVSCPSCGRAQVDVYKLA---NAVTDA 293
Cdd:PRK02048  467 LKAAADMGALIFDGLCDGIFLfnqgKLSHVVVDATAFGI--LQAGRLRTSKTEYISCPGCGRTLYDLQSTIariKEATSH 544
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2540601057 294 LKDeikvpLRVAVMGCVVNGPGEAREADLGVAsGNGKGKI-FIKGK--VIKTVPEEEIVPTLIA 354
Cdd:PRK02048  545 LKG-----LKIGIMGCIVNGPGEMADADYGYV-GAGRGKIsLYKQKecVEKNIPEEEAVERLIE 602
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
221-353 1.74e-12

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 68.63  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540601057 221 IKSATAFGALLRQGIGDTIRVSLSADPVEEIK-VGIEILQSMGLKERTLEIVSCPSCGRAQVDVYKlanaVTDALKDEI- 298
Cdd:PLN02925  584 IQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRnTSFGLLQGCRMRNTKTEYVSCPSCGRTLFDLQE----VSAEIREKTs 659
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2540601057 299 KVP-LRVAVMGCVVNGPGEAREADLGVAsGNGKGKIFI---KGKVIKTVPEEEIVPTLI 353
Cdd:PLN02925  660 HLPgVSIAIMGCIVNGPGEMADADFGYV-GGAPGKIDLyvgKEVVKRGIAMEEATDALI 717
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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