|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
37-590 |
3.31e-174 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 501.53 E-value: 3.31e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 37 SLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESElsvsseqlavsnskgkavqaqpsprlaqnsprefc 116
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAP----------------------------------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 117 pasGSLPIPHAPVfIRVDNARKVMAPVAAQFYDNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSGHKAGFISTVQYSLGG 196
Cdd:COG0769 46 ---GALLAAGVPV-IVVPDPRAALALLAAAFYGHPSQKLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGG 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 197 EAIanPQHQTTPEATIIQRQLHEMVENGCEYAVVETSSHGLSpkLNRTGNLLFDAGIFMNVTLEHLEFHGTFEQYRDDKA 276
Cdd:COG0769 122 ELI--PSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHALD--QGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKA 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 277 NLFRKLDEhnhektilgkkvtvPSFGIVNLEDPSAEYFIKATKQPVLGFTTEGKAgksaaegaeaaplpkipasipVLLG 356
Cdd:COG0769 198 RLFDQLGP--------------GGAAVINADDPYGRRLAAAAPARVITYGLKADA---------------------DLRA 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 357 RNIASARFGLTFDMTEPHvidshakplppKVFHVKSSLPGAFNTYNLMAAIeAVSRLTGTEIEKIAALVEKLTPVKGRMT 436
Cdd:COG0769 243 TDIELSADGTRFTLVTPG-----------GEVEVRLPLIGRFNVYNALAAI-AAALALGIDLEEILAALEKLKGVPGRME 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 437 VIDKGQPFELIVDYAHTPSSFETIFPPLRRRCSGKMFALFGSGGERDLKKRPLQGEIAARFCDVVILTDEDPRGEDSVEL 516
Cdd:COG0769 311 RVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAI 390
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2540711011 517 LKMIAAGAEKAGKVLdkdlfITPDRPSAIRQAFKMAGKDDIVLLLGKAHENSIIYKDRVMPYDEISEAEKALKE 590
Cdd:COG0769 391 IADILAGIPGAGKVL-----VIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALAE 459
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
32-580 |
6.69e-172 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 496.07 E-value: 6.69e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 32 NPEISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESELSVSSEqlavsnskgkavqaqpsprlaqns 111
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVA------------------------ 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 112 prefcpasgslPIPhapvFIRVDNARKVMAPVAAQFYDNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSGHKAGFISTVQ 191
Cdd:TIGR01085 57 -----------PVP----VIIVPDLRHALSSLAAAFYGHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIG 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 192 YSLGG-EAIANPQHQTTPEATIIQRQLHEMVENGCEYAVVETSSHGLSpkLNRTGNLLFDAGIFMNVTLEHLEFHGTFEQ 270
Cdd:TIGR01085 122 YRLGGnDLIKNPAALTTPEALTLQSTLAEMVEAGAQYAVMEVSSHALA--QGRVRGVRFDAAVFTNLSRDHLDFHGTMEN 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 271 YRDDKANLFRKLDEHnhektilgkkvtvpSFGIVNLEDPSAEYFIKATKQPVLGFTTEGKAGKSAAEgaeaaplPKIpas 350
Cdd:TIGR01085 200 YFAAKASLFTELGLK--------------RFAVINLDDEYGAQFVKRLPKDITVSAITQPADGRAQD-------IKI--- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 351 ipvllgRNIASARFGLTFDMTEPHvidshakplppKVFHVKSSLPGAFNTYNLMAAIEAVSRLTGTEIEKIAALVEKLTP 430
Cdd:TIGR01085 256 ------TDSGYSFEGQQFTFETPA-----------GEGHLHTPLIGRFNVYNLLAALATLLHLGGIDLEDIVAALEKFRG 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 431 VKGRMTVIDKGQPFELIVDYAHTPSSFETIFPPLRRRCSGKMFALFGSGGERDLKKRPLQGEIAARFCDVVILTDEDPRG 510
Cdd:TIGR01085 319 VPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDNPRG 398
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 511 EDSVELLKMIAAGAEKAGKVldkdlFITPDRPSAIRQAFKMAGKDDIVLLLGKAHENSIIYKDRVMPYDE 580
Cdd:TIGR01085 399 EDPEQIIADILAGISEKEKV-----VIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDD 463
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
27-591 |
2.29e-150 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 440.72 E-value: 2.29e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 27 QEESANPEISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESELSvsseqlavsnskgkavqaqpspr 106
Cdd:PRK00139 7 RDLLAPVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGE----------------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 107 laqnsprefcpasgslPIPHAPVfIRVDNARKVMAPVAAQFYDNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSGHKAGF 186
Cdd:PRK00139 64 ----------------AGTGVPV-IIVPDLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTAL 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 187 ISTVQYSLGGEAIanPQHQTTPEATIIQRQLHEMVENGCEYAVVETSSHGLspKLNRTGNLLFDAGIFMNVTLEHLEFHG 266
Cdd:PRK00139 127 IGTLGNGIGGELI--PSGLTTPDALDLQRLLAELVDAGVTYAAMEVSSHAL--DQGRVDGLKFDVAVFTNLSRDHLDYHG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 267 TFEQYRDDKANLFRKLDehnhektilgkkvtvpSFGIVNLEDPSAEYFIKATKqpVLGFTTEGKAgksaaegaeaaplpk 346
Cdd:PRK00139 203 TMEDYLAAKARLFSELG----------------LAAVINADDEVGRRLLALPD--AYAVSMAGAD--------------- 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 347 ipasipvLLGRNIASARFGLTFDMtephvidshakplppkVFHVKSSLPGAFNTYNLMAAIeAVSRLTGTEIEKIAALVE 426
Cdd:PRK00139 250 -------LRATDVEYTDSGQTFTL----------------VTEVESPLIGRFNVSNLLAAL-AALLALGVPLEDALAALA 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 427 KLTPVKGRMTVIDKGQPFELIVDYAHTPSSFETIFPPLRRRCSGKMFALFGSGGERDLKKRPLQGEIAARFCDVVILTDE 506
Cdd:PRK00139 306 KLQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVTSD 385
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 507 DPRGEDSVELLKMIAAGAEKagkvldkdlfITPDRPSAIRQAFKMAGKDDIVLLLGKAHENSIIYKDRVMPYDEISEAEK 586
Cdd:PRK00139 386 NPRSEDPAAIIADILAGIYD----------VIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDDREVARE 455
|
....*
gi 2540711011 587 ALKEL 591
Cdd:PRK00139 456 ALAER 460
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-590 |
3.66e-105 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 338.99 E-value: 3.66e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 27 QEESANPEISSL----------VFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESElsvsseqlavsnskg 96
Cdd:PRK11929 11 KLEELLQALAWLrgcvaatadlRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAE--------------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 97 kavqaqpsprlaqnsprefcpasGSLPIPHAPV-FIRVDNARKVMAPVAAQFYDNPSSKLAVIGVTGTEGKSSTVSFVWQ 175
Cdd:PRK11929 76 -----------------------GEDQVAAADAlVLPVADLRKALGELAARWYGRPSEQLSLVAVTGTNGKTSCAQLLAQ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 176 LLQLSGHKAGFISTVQYSLGGEAIanPQHQTTPEATIIQRQLHEMVENGCEYAVVETSSHGLspKLNRTGNLLFDAGIFM 255
Cdd:PRK11929 133 LLTRLGKPCGSIGTLGARLDGRLI--PGSLTTPDAIILHRILARMRAAGADAVAMEASSHGL--EQGRLDGLRIAVAGFT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 256 NVTLEHLEFHGTFEQYRDDKANLFRKLDEhnhektiLGkkvtvpsFGIVNLEDPSAEYFIKAtkqpvlgfttEGKAGKSA 335
Cdd:PRK11929 209 NLTRDHLDYHGTMQDYEEAKAALFSKLPG-------LG-------AAVINADDPAAARLLAA----------LPRGLKVG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 336 AEGAEAaplpkiPASIPVllgRNIASARFGLTFDMTEPHvidshakplppKVFHVKSSLPGAFNTYNLMAAIEAVSRLtG 415
Cdd:PRK11929 265 YSPQNA------GADVQA---RDLRATAHGQVFTLATPD-----------GSYQLVTRLLGRFNVSNLLLVAAALKKL-G 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 416 TEIEKIAALVEKLTPVKGRMTVID----KGQPFeLIVDYAHTPSSFETIFPPLR---RRCSGKMFALFGSGGERDLKKRP 488
Cdd:PRK11929 324 LPLAQIARALAAVSPVPGRMERVGptagAQGPL-VVVDYAHTPDALAKALTALRpvaQARNGRLVCVFGCGGDRDKGKRP 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 489 LQGEIAARFCDVVILTDEDPRGEDSVELLKMIAAGAEKAGKVldkdlFITPDRPSAIRQAFKMAGKDDIVLLLGKAHENS 568
Cdd:PRK11929 403 EMGRIAAELADRVVVTSDNPRSEAPEAIIDQILAGIPAGARV-----FVISDRAEAIRQAIWMAAPGDVILIAGKGHETY 477
|
570 580
....*....|....*....|..
gi 2540711011 569 IIYKDRVMPYDEISEAEKALKE 590
Cdd:PRK11929 478 QEIGGRKLFFDDREWARRALLA 499
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
32-566 |
4.04e-68 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 228.77 E-value: 4.04e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 32 NPEISSLVFDSRDVKPGSLFFALPGThtTGNVFIPKAIENGASAIVFESELSVSSEQLAVSNSKgkavqaqpsprlaqns 111
Cdd:PRK14022 31 GVQFDDISYDSRTADEGTLFFAKGAY--FKHKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIK---------------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 112 prefcpasgslpiphapvfirvdnarKVMAPVAAQFYDNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSgHKAGFISTVQ 191
Cdd:PRK14022 93 --------------------------KAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQL-HKPAMLSTMN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 192 YSLGGEAIANPQHqTTPEATIIQRQLHEMVENGCEYAVVETSSHGLSpkLNRTGNLLFDAGIFMNVTLEHLEF--HGTFE 269
Cdd:PRK14022 146 TTLDGETFFKSAL-TTPESLDLFKMMAEAVDNGMTHLIMEVSSQAYL--VGRVYGLTFDVGVFLNITPDHIGPieHPTFE 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 270 QYRDDKANLFRkldehnHEKTIlgkkvtvpsfgIVNLE-DPSAEYFIKATKQPVLGFttegkagksaaeGAEAAPlpkip 348
Cdd:PRK14022 223 DYFYHKRLLME------NSKAV-----------VVNSDmDHFSELLEQVTPQEHDFY------------GIDSEN----- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 349 asipvllgrniasarfgltfDMTEPHVIDSHAKPLPPKVFHVKssLPGAFNTYNLMAAIEAVSRLtGTEIEKIAALVEKl 428
Cdd:PRK14022 269 --------------------QIMASNAFSFEATGKLAGTYDIQ--LIGKFNQENAMAAGLACLRL-GASLEDIQKGIAQ- 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 429 TPVKGRMTVIDKGQPFELIVDYAHTPSSFETIFPPLRRRCSGKMFALFGSGGERDLKKRPLQGEIAARFCDV-VILTDED 507
Cdd:PRK14022 325 TPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLqVILTADD 404
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 508 PRGEDSVELLKMIAAGAekagkvlDKDLFITPDRPSAIRQAFKMA-GKDDIVLLLGKAHE 566
Cdd:PRK14022 405 PNNEDPKMITQEIASHI-------THPVEIIDDRAEAIKHAMSITeGPGDAVIIAGKGAD 457
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
160-410 |
1.84e-39 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 143.21 E-value: 1.84e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 160 VTGTEGKSSTVSFVWQLLQLSGhkaGFISTVQYSLggeaiaNPQHQTTPEATIIQRQLHEMVENGCEYAVVETSSHGLsp 239
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAG---GVIGTIGTYI------GKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGL-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 240 KLNRTGNLL-FDAGIFMNVTLEHLEFHGTFEQYRDDKANLFRKLDEHNhektilgkkvtvpsFGIVNLEDPSAEYFIKAT 318
Cdd:pfam08245 70 GEGRLSGLLkPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDG--------------IAVINADDPYGAFLIAKL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 319 K---QPVLGFTTEGKAgksaaegaeaaplpkipasipVLLGRNIASARFGLTFDMTEPhvidshakplPPKVFHVKSSLP 395
Cdd:pfam08245 136 KkagVRVITYGIEGEA---------------------DLRAANIELSSDGTSFDLFTV----------PGGELEIEIPLL 184
|
250
....*....|....*
gi 2540711011 396 GAFNTYNLMAAIEAV 410
Cdd:pfam08245 185 GRHNVYNALAAIAAA 199
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
30-560 |
8.90e-29 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 119.44 E-value: 8.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 30 SANPEISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESELSVSSEQLAVSNSKgKAVQaqpspRLAQ 109
Cdd:COG0770 19 DPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVVDDTL-KALQ-----QLAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 110 nsprefcpasgslpiphapvFIRvdnarkvmapvaAQFydnpssKLAVIGVTGTEGKSSTVSFVWQLLQLSGHkagfist 189
Cdd:COG0770 93 --------------------AHR------------ARF------NIPVIAITGSNGKTTTKEMLAAVLSTKGK------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 190 VQYSLGgeaiaN-------PQhqttpeaTIIQrqlhemVENGCEYAVVE--TSSHG----LS----PklnrtgnllfDAG 252
Cdd:COG0770 128 VLATPG-----NfnneigvPL-------TLLR------LPEDHEFAVLEmgMNHPGeiayLAriarP----------DIA 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 253 IFMNVTLEHLEFHGTFEQYRDDKANLFRKLDEHnhektilgkkvtvpSFGIVNLEDPSAEYFIKATKQPVLGFTTEGKAG 332
Cdd:COG0770 180 VITNIGPAHLEGFGSLEGIARAKGEIFEGLPPG--------------GVAVLNADDPLLAALAERAKARVLTFGLSEDAD 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 333 ksaaegaeaaplpkipasipvLLGRNIASARFGLTFDMTephvidshakpLPPKVFHVKSSLPGAFNTYNLMAAIeAVSR 412
Cdd:COG0770 246 ---------------------VRAEDIELDEDGTRFTLH-----------TPGGELEVTLPLPGRHNVSNALAAA-AVAL 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 413 LTGTEIEKIAALVEKLTPVKGRMTVIDKGQPFELIVD-Y-AhTPSSF----ETI--FPPLRRRCS--GKMFALfGSGGE- 481
Cdd:COG0770 293 ALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDsYnA-NPDSMkaalDVLaqLPGGGRRIAvlGDMLEL-GEESEe 370
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 482 --RDLkkrplqGEIAARF-CDVVILTdedprGEDSVELLKmiAAGAEKAGKVLDKDlfitpdrpSAIRQAFKMAGKDDIV 558
Cdd:COG0770 371 lhREV------GELAAELgIDRLFTV-----GELARAIAE--AAGGERAEHFEDKE--------ELLAALKALLRPGDVV 429
|
..
gi 2540711011 559 LL 560
Cdd:COG0770 430 LV 431
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
431-515 |
6.53e-22 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 90.10 E-value: 6.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 431 VKGRMTVIDKGQPFELIVDYAHTPSSFETIFPPLRRRCSGKMFALFGSGGERDLKKRPLQGEIAARFCDVVILTDEDPRG 510
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYPRA 80
|
....*
gi 2540711011 511 EDSVE 515
Cdd:pfam02875 81 EDPGA 85
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
125-435 |
2.83e-19 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 90.53 E-value: 2.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 125 PHAPVFIRvdnARKVMAPV------AAQFYDNPssklaVIGVTGTEGKSSTVSFVWQLLQLSGHKAGfistvqysLGG-- 196
Cdd:COG0771 77 PDHPLLKA---ARAAGIPVigeielAYRLSPAP-----IIAITGTNGKTTTTTLIGHILKAAGLRVA--------VGGni 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 197 -----EAIANPQhqttpeatiiqrqlhemvenGCEYAVVETSS------HGLSPklnrtgnllfDAGIFMNVTLEHLEFH 265
Cdd:COG0771 141 gtpllDLLLEPE--------------------PPDVYVLELSSfqlettPSLRP----------DVAVILNITPDHLDRH 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 266 GTFEQYRDDKANLFRKLdehnhektilgkkvTVPSFGIVNLEDPSAEYFIKATKQPVLGFTTEGKAGKSAaegaeaaplp 345
Cdd:COG0771 191 GSMEAYAAAKARIFANQ--------------TPDDYAVLNADDPLTRALAEEAKARVVPFSLKEPLEGGA---------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 346 kipasipVLLGRNIasarfgltfdmtephVIDSHAKPLppkvFHVKS-SLPGAFNTYNLMAAIeAVSRLTGTEIEKIAAL 424
Cdd:COG0771 247 -------GLEDGKL---------------VDRASGEEL----LPVDDlRLPGRHNLENALAAL-AAARALGVPPEAIREA 299
|
330
....*....|.
gi 2540711011 425 VEKLTPVKGRM 435
Cdd:COG0771 300 LRSFKGLPHRL 310
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
40-457 |
5.63e-19 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 89.63 E-value: 5.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 40 FDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVfeselsVSSEQLavsnskgkavqaqPSPRLAQnsprefcpas 119
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVV------VDREVG-------------PDNGLPQ---------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 120 gslpiphapvfIRVDNARKVMAPVAAQFYDNPSSKlaVIGVTGTEGKSSTVSFVWQLLQlsgHKAGFISTvQYSLGGEaI 199
Cdd:TIGR01143 52 -----------ILVDDTLEALQALARAKRAKFSGK--VIGITGSSGKTTTKEMLAAILS---HKYKVFAT-PGNFNNE-I 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 200 ANPQhqttpeaTIIQrqlhemVENGCEYAVVEtssHGLSpKLNRTGNLLF----DAGIFMNVTLEHLEFHGTFEQYRDDK 275
Cdd:TIGR01143 114 GLPL-------TLLR------APGDHDYAVLE---MGAS-HPGEIAYLAEiakpDIAVITNIGPAHLEGFGSLEGIAEAK 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 276 ANLFRKLDEHnhektilgkkvtvpSFGIVNLEDPSAEYFIKATKQ-PVLGFTTEGKAGKSAaegaeaaplpkipasipVL 354
Cdd:TIGR01143 177 GEILQGLKEN--------------GIAVINADDPAFADLAKRLPNrNILSFGFEGGDFVAK-----------------DI 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 355 LGRNIASARFGLtfdmtepHVIDSHAK-PLPpkvfhvkssLPGAFNTYNLMAAIeAVSRLTGTEIEKIAALVEKLTPVKG 433
Cdd:TIGR01143 226 SYSALGSTSFTL-------VAPGGEFEvSLP---------LLGRHNVMNALAAA-ALALELGIPLEEIAEGLAELKLVKG 288
|
410 420
....*....|....*....|....*
gi 2540711011 434 RMTVIDKgQPFELIVD-YAHTPSSF 457
Cdd:TIGR01143 289 RFEVQTK-NGLTLIDDtYNANPDSM 312
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
143-438 |
1.53e-18 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 88.17 E-value: 1.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 143 VAAQFYDNPssklaVIGVTGTEGKSSTVSFVWQLLQLSGHKAGfistvqysLGGEaIANPQhqttpeatiiqrqLHEMVE 222
Cdd:TIGR01087 95 LFLRLVPLP-----VVAITGTNGKTTTTSLLYHLLKAAGLKAF--------LGGN-IGTPA-------------LEVLDQ 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 223 NGCEYAVVETSSHglspKLNRTGNLLFDAGIFMNVTLEHLEFHGTFEQYRDDKANLFRKLDEHnhektilgkkvtvpSFG 302
Cdd:TIGR01087 148 EGAELYVLELSSF----QLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEG--------------DVA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 303 IVNLEDPSAEYFIKATKQPVLGFTTEGKAGKSAaegaeaaplpKIPASIPVLlgrniasarfgltfdmtephvidshakp 382
Cdd:TIGR01087 210 VLNADDPRFARLAQKSKAQVIWFSVEKDAERGL----------CIRDGGLYL---------------------------- 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2540711011 383 lppKVFHVKSSLPGAFNTYNLMAAIeAVSRLTGTEIEKIAALVEKLTPVKGRMTVI 438
Cdd:TIGR01087 252 ---KPNDLEGSLLGLHNAENILAAI-ALAKSLGLNLEAILEALRSFKGLPHRLEYV 303
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
157-562 |
8.52e-15 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 77.03 E-value: 8.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 157 VIGVTGTEGKSSTVSFVWQLLQLSGHKAGFIstvqysLGGEaianpqhqttpeatiiqrqlhemVEN--------GCEYA 228
Cdd:COG0773 106 SIAVAGTHGKTTTTSMLAHILEEAGLDPTFL------IGGI-----------------------LNNfgtnarlgDGDYF 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 229 VVE-----TSSHGLSPklnrtgnllfDAGIFMNVTLEHLEFHGTFEQYRDdkAnlFRKLDEhnhektilgkkvTVPSFG- 302
Cdd:COG0773 157 VAEadesdGSFLHYSP----------DIAVVTNIEADHLDIYGDLEAIKE--A--FHEFAR------------NVPFYGl 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 303 -IVNLEDPSAEYFIKATKQPVLGFTTEGKAGKSAaegaeaaplpkipasipvllgRNIASARFGLTFDMTEPHVidshak 381
Cdd:COG0773 211 lVLCADDPGLRELLPRCGRPVITYGFSEDADYRA---------------------ENIRIDGGGSTFDVLRRGE------ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 382 plppKVFHVKSSLPGAFNTYNLMAAIeAVSRLTGTEIEKIAALVEKLTPVKGRMTVIDKGQPFELIVDYAHTPS------ 455
Cdd:COG0773 264 ----ELGEVELNLPGRHNVLNALAAI-AVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDYAHHPTeiaatl 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 456 -SFETIFPplrrrcSGKMFALFgsggE-------RDLKKrplqgEIAARF--CDVVILTDEDPRGEDSVE--LLKMIAAG 523
Cdd:COG0773 339 aAAREKYP------DRRLVAVF----QphrysrtRDFLD-----EFAEALslADEVILLDIYAAREKPIPgvSSEDLAEA 403
|
410 420 430
....*....|....*....|....*....|....*....
gi 2540711011 524 AEKAGkvldKDLFITPDRPSAIRQAFKMAGKDDIVLLLG 562
Cdd:COG0773 404 IRKRG----KDVVYVPDLDELVEALAEIARPGDVVLTMG 438
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
24-481 |
5.79e-14 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 75.13 E-value: 5.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 24 ELSQEESANPEISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFEselsvsseqlavsnskgkavQAQP 103
Cdd:PRK11929 515 SNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVE--------------------RQVA 574
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 104 SPRLAQnsprefcpasgslpiphapvfIRVDNARKVMAPVAAQFYDNPSSKlaVIGVTGTEGKSSTVSFVWQLLQlsghK 183
Cdd:PRK11929 575 DVDLPQ---------------------IVVDDTRAALGRLATAWRARFSLP--VVAITGSNGKTTTKEMIAAILA----A 627
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 184 AGFISTVQYSLGgeaiaNPQHQTTPEATIIQrqlhemVENGCEYAVVETSshglspkLNRTGNLLF-------DAGIFMN 256
Cdd:PRK11929 628 WQGEDRVLATEG-----NFNNEIGVPLTLLR------LRAQHRAAVFELG-------MNHPGEIAYlaaiaapTVALVTN 689
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 257 VTLEHLEFHGTFEQYRDDKANLFRKLDEhnhektilgKKVTVpsfgiVNLEDPSAEYFIKATKQPVLGFTTEGKAGKSAA 336
Cdd:PRK11929 690 AQREHQEFMHSVEAVARAKGEIIAALPE---------DGVAV-----VNGDDPYTAIWAKLAGARRVLRFGLQPGADVYA 755
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 337 EgAEAAPLPKIPASipvllgrniaSARFGLtfdmtepHVIDSHAK-PLPpkvfhvkssLPGAFNTYNLMAAIeAVSRLTG 415
Cdd:PRK11929 756 E-KIAKDISVGEAG----------GTRCQV-------VTPAGSAEvYLP---------LIGEHNLRNALAAI-ACALAAG 807
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2540711011 416 TEIEKIAALVEKLTPVKGRMTVIDKGQPFELIVD-YAHTPSSFETIFPPLRRRCSGKMFALFGSGGE 481
Cdd:PRK11929 808 ASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGDMLE 874
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
149-562 |
5.93e-10 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 61.66 E-value: 5.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 149 DNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSGHKAG-FIS------TVQYSLGGEAIanpqhqttPEATIIQ-----RQ 216
Cdd:COG0285 34 GNPQRKLPVIHVAGTNGKGSTAAMLESILRAAGYRVGlYTSphlvrfNERIRINGEPI--------SDEELVEaleevEP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 217 LHEMV--------------------ENGCEYAVVETsshGL----------SPklnrtgnllfDAGIFMNVTLEHLEFHG 266
Cdd:COG0285 106 AVEEVdagpptffevttaaaflyfaEAPVDVAVLEV---GLggrldatnviDP----------LVSVITSIGLDHTDFLG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 267 T------FEqyrddKAnlfrkldehnhektilgkkvtvpsfGIvnledpsaeyfIKATKQPVLGFTTEGkAGKSAAEGAE 340
Cdd:COG0285 173 DtleeiaRE-----KA-------------------------GI-----------IKPGVPVVTGDQQPE-ALEVIEERAA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 341 A--APLpkipasipVLLGRNiasarFGLTFDMTEPHVIDSHAKPLPpkvfHVKSSLPGAFNTYNLMAAIEAVSRLT--GT 416
Cdd:COG0285 211 ElgAPL--------YRAGRD-----FSVEEREGAVFSYQGPGGEYE----DLPLPLLGAHQAENAALALAALEALRelGL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 417 EI--EKIAALVEKLTpVKGRMTVIDKGqPfELIVDYAHTP-------SSFETIFPPlrrrcsGKMFALFGSGGERDLKK- 486
Cdd:COG0285 274 PIseEAIREGLANAR-WPGRLEVLSRG-P-LVILDGAHNPagaralaETLKELFPF------RKLHLVFGMLADKDIEGm 344
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2540711011 487 -RPLqgeiaARFCDVVILTD-EDPRGEDSVELLKMIAAgaekagkvLDKDLFITPDRPSAIRQAFKMAGKDDIVLLLG 562
Cdd:COG0285 345 lAAL-----APLADEVIVTTpPSPRALDAEELAEAARE--------LGLRVEVAPDVEEALEAALELADPDDLILVTG 409
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
34-81 |
1.79e-09 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 54.55 E-value: 1.79e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2540711011 34 EISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESE 81
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDA 48
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
32-177 |
1.08e-06 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 51.88 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 32 NPEISSLVFDSRDVK--PGSLFFALPGTHTTGNVFIPKAIENGASAIVfeselsvsseqlavsnskgkaVQAQPSPrlaq 109
Cdd:PRK11930 21 DAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFV---------------------VSEEKHP---- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2540711011 110 nsPREFCPASgslpiphapvFIRVDNARKVMAPVAA----QFydnpssKLAVIGVTGTEGKSSTVSFVWQLL 177
Cdd:PRK11930 76 --EESYPDAN----------FLKVKDPLKALQELAAyhrsQF------DIPVIGITGSNGKTIVKEWLYQLL 129
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
153-284 |
4.20e-06 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 49.58 E-value: 4.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 153 SKLAVIGVTGTEGKSSTVSFVWQLLQLSGHK---AG-----FISTVQyslggeaianpqhqTTPEATIIqrqlhemveng 224
Cdd:PRK14106 106 SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKtlvAGnigypLIDAVE--------------EYGEDDII----------- 160
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2540711011 225 ceyaVVETSS------HGLSPKLnrtgnllfdaGIFMNVTLEHLEFHGTFEQYRDDKANLFRKLDE 284
Cdd:PRK14106 161 ----VAEVSSfqletiKEFKPKV----------GCILNITPDHLDRHKTMENYIKAKARIFENQRP 212
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
31-95 |
9.41e-06 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 48.49 E-value: 9.41e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2540711011 31 ANPEISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESELSVSSEQLAVSNSK 95
Cdd:PRK10773 20 ADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVVKDTR 84
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
137-437 |
9.86e-06 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 48.61 E-value: 9.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 137 RKVMAPVAAQ-FYDNPSSKLAVIGVTGTEGKSSTVSFVWQLLQLSGHKAGFISTvqyslGGEAIANPQHQTT----PEAT 211
Cdd:PRK14016 461 RNVGEAIVDMlFPEGDDGRIPIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTT-----DGVYIDGRLIDKGdctgPKSA 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 212 iiQRQL-HEMVengcEYAVVETSSHGLspkLnRTGnLLFD---AGIFMNVTLEHLEFHGTFEQyrDDKANLFRkldehnh 287
Cdd:PRK14016 536 --RRVLmNPDV----EAAVLETARGGI---L-REG-LAYDrcdVGVVTNIGEDHLGLGGINTL--EDLAKVKR------- 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 288 ekTILgkKVTVPS-FGIVNLEDPSAEYFIKATKQPVLGFTTEG---------KAGKSA----------AEGAEAAPLPKI 347
Cdd:PRK14016 596 --VVV--EAVKPDgYAVLNADDPMVAAMAERCKGKVIFFSMDPdnpviaehrAQGGRAvyvegdyivlAEGGWEIRIISL 671
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2540711011 348 pASIPVLLGRNIasarfgltfdmtephvidshakplppkvfhvksslpgAFNTYNLMAAIEAVSRLtGTEIEKIAALVEK 427
Cdd:PRK14016 672 -ADIPLTLGGKA-------------------------------------GFNIENALAAIAAAWAL-GIDIELIRAGLRT 712
|
330
....*....|....
gi 2540711011 428 LTP----VKGRMTV 437
Cdd:PRK14016 713 FVSdaaqAPGRFNL 726
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
35-81 |
9.49e-03 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 38.60 E-value: 9.49e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2540711011 35 ISSLVFDSRDVKPGSLFFALPGTHTTGNVFIPKAIENGASAIVFESE 81
Cdd:PRK14093 28 VTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERA 74
|
|
| |
