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Conserved domains on  [gi|2541254367|ref|WP_297366849|]
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OmpA family protein [Acidocella sp.]

Protein Classification

OmpA family protein( domain architecture ID 1000806)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes, similar to peptidoglycan-associated lipoprotein that is involved in maintenance of the integrity of the cell cell envelope

CATH:  3.30.1330.60
Gene Ontology:  GO:0042834|GO:0015288
SCOP:  4001470
TCDB:  1.B.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA_C-like super family cl30079
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 113-199 7.75e-10

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


The actual alignment was detected with superfamily member pfam00691:

Pssm-ID: 453091 [Multi-domain]  Cd Length: 95  Bit Score: 53.90  E-value: 7.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 113 FAPQSAALPDSAAQALAPYCQA------KVRLTISAHAPLTGSAPsAAMRLSLARAQAVQAALEACGVPAANIIPRALGp 186
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLlkfpelKNTITIEGHTDTVGSAA-YNWELSQRRAEAVRRYLVNFGVPPSRISVVGYG- 78

                          90
                  ....*....|...
gi 2541254367 187 APTPADDDTVSVG 199
Cdd:pfam00691  79 ATKPITDNKTPEG 91
 
Name Accession Description Interval E-value
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 113-199 7.75e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 53.90  E-value: 7.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 113 FAPQSAALPDSAAQALAPYCQA------KVRLTISAHAPLTGSAPsAAMRLSLARAQAVQAALEACGVPAANIIPRALGp 186
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLlkfpelKNTITIEGHTDTVGSAA-YNWELSQRRAEAVRRYLVNFGVPPSRISVVGYG- 78

                          90
                  ....*....|...
gi 2541254367 187 APTPADDDTVSVG 199
Cdd:pfam00691  79 ATKPITDNKTPEG 91
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 108-195 1.40e-09

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 53.33  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 108 PLRLSFAPQSAALPDSAAQALAPYCQA-----KVRLTISAHAPLTGSAPSAaMRLSLARAQAVQAALEACGVPAANIIPR 182
Cdd:cd07185     1 LITIYFDFGSAELTPEAKPLLDKLAEVlkknpDAKIRIEGHTDSRGSDAYN-QELSERRAEAVADYLVSKGVDASRITAV 79

                          90
                  ....*....|...
gi 2541254367 183 ALGPAPTPADDDT 195
Cdd:cd07185    80 GYGESRPIASNDT 92
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 113-195 3.96e-08

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 52.09  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 113 FAPQSAALPDSAAQAL---APYCQA--KVRLTISAHAPLTGSApSAAMRLSLARAQAVQAALEACGVPAANIIPRALGPA 187
Cdd:COG2885   191 FDFDSAELTPEAKAALdelAALLKEnpDLRIEIEGHTDSRGSD-AYNLALSERRAEAVKDYLVSKGIPASRITAVGYGES 269


                  ....*...
gi 2541254367 188 PTPADDDT 195
Cdd:COG2885   270 RPVASNDT 277
 
Name Accession Description Interval E-value
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 113-199 7.75e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 53.90  E-value: 7.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 113 FAPQSAALPDSAAQALAPYCQA------KVRLTISAHAPLTGSAPsAAMRLSLARAQAVQAALEACGVPAANIIPRALGp 186
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLlkfpelKNTITIEGHTDTVGSAA-YNWELSQRRAEAVRRYLVNFGVPPSRISVVGYG- 78

                          90
                  ....*....|...
gi 2541254367 187 APTPADDDTVSVG 199
Cdd:pfam00691  79 ATKPITDNKTPEG 91
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 108-195 1.40e-09

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 53.33  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 108 PLRLSFAPQSAALPDSAAQALAPYCQA-----KVRLTISAHAPLTGSAPSAaMRLSLARAQAVQAALEACGVPAANIIPR 182
Cdd:cd07185     1 LITIYFDFGSAELTPEAKPLLDKLAEVlkknpDAKIRIEGHTDSRGSDAYN-QELSERRAEAVADYLVSKGVDASRITAV 79

                          90
                  ....*....|...
gi 2541254367 183 ALGPAPTPADDDT 195
Cdd:cd07185    80 GYGESRPIASNDT 92
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 113-195 3.96e-08

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 52.09  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541254367 113 FAPQSAALPDSAAQAL---APYCQA--KVRLTISAHAPLTGSApSAAMRLSLARAQAVQAALEACGVPAANIIPRALGPA 187
Cdd:COG2885   191 FDFDSAELTPEAKAALdelAALLKEnpDLRIEIEGHTDSRGSD-AYNLALSERRAEAVKDYLVSKGIPASRITAVGYGES 269


                  ....*...
gi 2541254367 188 PTPADDDT 195
Cdd:COG2885   270 RPVASNDT 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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