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Conserved domains on  [gi|2541256199|ref|WP_297368681|]
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peptide chain release factor 1 [Acidocella sp.]

Protein Classification

peptide chain release factor 1( domain architecture ID 11479061)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0005829|GO:0043022|GO:0006415|GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
prfA PRK00591
peptide chain release factor 1; Validated
 3-354 0e+00

peptide chain release factor 1; Validated


:

Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 605.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   3 PALEQKLDRILARAEELRFHLGQGGL--SGEAFVKASKELSELEPVEAQVTALRQAETSLADAQALL---LDPEMKDLAE 77
Cdd:PRK00591    2 PSMLDKLEALEERYEELEALLSDPEVisDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLeeeSDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  78 AEIAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGI 157
Cdd:PRK00591   82 EELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 158 KGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNKT 237
Cdd:PRK00591  162 KEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 238 ESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTDH 317
Cdd:PRK00591  242 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDH 321

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2541256199 318 RINLTLYKIDRVMQGEMDEIIDALIAEDQAARLAEAE 354
Cdd:PRK00591  322 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
 
Name Accession Description Interval E-value
prfA PRK00591
peptide chain release factor 1; Validated
 3-354 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 605.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   3 PALEQKLDRILARAEELRFHLGQGGL--SGEAFVKASKELSELEPVEAQVTALRQAETSLADAQALL---LDPEMKDLAE 77
Cdd:PRK00591    2 PSMLDKLEALEERYEELEALLSDPEVisDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLeeeSDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  78 AEIAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGI 157
Cdd:PRK00591   82 EELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 158 KGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNKT 237
Cdd:PRK00591  162 KEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 238 ESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTDH 317
Cdd:PRK00591  242 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDH 321

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2541256199 318 RINLTLYKIDRVMQGEMDEIIDALIAEDQAARLAEAE 354
Cdd:PRK00591  322 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 5-354 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 604.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   5 LEQKLDRILARAEELRFHLGQGGLSG--EAFVKASKELSELEPVEAQVTALRQAETSLADAQALL---LDPEMKDLAEAE 79
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISdqKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLeeeSDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  80 IAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKG 159
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 160 AMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNKTES 239
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 240 AVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTDHRI 319
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2541256199 320 NLTLYKIDRVMQGEMDEIIDALIAEDQAARLAEAE 354
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-352 2.16e-175

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 491.13  E-value: 2.16e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   1 MTPALEQKLDRILARAEELRFHLGQGGLSGEA--FVKASKELSELEPVEAQVTALRQAETSLADAQALL--LDPEMKDLA 76
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQdkLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILeeSDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  77 EAEIAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGG 156
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 157 IKGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNK 236
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 237 TESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTD 316
Cdd:TIGR00019 241 TDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTD 320

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2541256199 317 HRINLTLYKIDRVMQGEMDEIIDALIAEDQAARLAE 352
Cdd:TIGR00019 321 HRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAA 356
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-201 1.09e-82

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 249.22  E-value: 1.09e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  12 ILARAEELRFHLGQGGLSG--EAFVKASKELSELEPVEAQVTALRQAETSLADAQALLLDPEMKDLAEAEIAELRAHLPA 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDdqKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAELAEEELEELEKRLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  90 LEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSV 169
Cdd:pfam03462  81 LEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGA 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2541256199 170 FAKLKFESGVHRVQRVPATETQGRIHTSTITV 201
Cdd:pfam03462 161 YGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
69-176 5.24e-41

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 139.52  E-value: 5.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   69 DPEMKDLAEAEIAELRAHL-PALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVL 147
Cdd:smart00937   8 DDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKVEVL 87

                           90       100
                   ....*....|....*....|....*....
gi 2541256199  148 EYDESELGGIKGAMAEITGRSVFAKLKFE 176
Cdd:smart00937  88 DESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfA PRK00591
peptide chain release factor 1; Validated
 3-354 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 605.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   3 PALEQKLDRILARAEELRFHLGQGGL--SGEAFVKASKELSELEPVEAQVTALRQAETSLADAQALL---LDPEMKDLAE 77
Cdd:PRK00591    2 PSMLDKLEALEERYEELEALLSDPEVisDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLeeeSDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  78 AEIAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGI 157
Cdd:PRK00591   82 EELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 158 KGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNKT 237
Cdd:PRK00591  162 KEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 238 ESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTDH 317
Cdd:PRK00591  242 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDH 321

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2541256199 318 RINLTLYKIDRVMQGEMDEIIDALIAEDQAARLAEAE 354
Cdd:PRK00591  322 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 5-354 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 604.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   5 LEQKLDRILARAEELRFHLGQGGLSG--EAFVKASKELSELEPVEAQVTALRQAETSLADAQALL---LDPEMKDLAEAE 79
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISdqKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLeeeSDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  80 IAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKG 159
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 160 AMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNKTES 239
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 240 AVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTDHRI 319
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2541256199 320 NLTLYKIDRVMQGEMDEIIDALIAEDQAARLAEAE 354
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-352 2.16e-175

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 491.13  E-value: 2.16e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   1 MTPALEQKLDRILARAEELRFHLGQGGLSGEA--FVKASKELSELEPVEAQVTALRQAETSLADAQALL--LDPEMKDLA 76
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQdkLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILeeSDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  77 EAEIAELRAHLPALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGG 156
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 157 IKGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEAEEVDVAINDSDLRIDVYRASGAGGQHVNK 236
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 237 TESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAADRKSQVGTGDRSERIRTYNFPQGRVTD 316
Cdd:TIGR00019 241 TDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTD 320

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2541256199 317 HRINLTLYKIDRVMQGEMDEIIDALIAEDQAARLAE 352
Cdd:TIGR00019 321 HRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAA 356
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-201 1.09e-82

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 249.22  E-value: 1.09e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  12 ILARAEELRFHLGQGGLSG--EAFVKASKELSELEPVEAQVTALRQAETSLADAQALLLDPEMKDLAEAEIAELRAHLPA 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDdqKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAELAEEELEELEKRLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  90 LEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSV 169
Cdd:pfam03462  81 LEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGA 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2541256199 170 FAKLKFESGVHRVQRVPATETQGRIHTSTITV 201
Cdd:pfam03462 161 YGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 4-342 3.59e-79

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 246.61  E-value: 3.59e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   4 ALEQKLDRILARAEELRFHLGQgglsgeafVKASKELSELEPVEAQVTALRQAETSLADAQALL-LDPEMKDlaEAEIAE 82
Cdd:TIGR00020  27 KKKARLEELEKEMEDPNFWNDQ--------ERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLeLAVEEDD--EETFNE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  83 LRAHLPALEHEVR---LALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKG 159
Cdd:TIGR00020  97 LDAELKALEKKLAeleLRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 160 AMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTITVAVLPEA-EEVDVAINDSDLRIDVYRASGAGGQHVNKTE 238
Cdd:TIGR00020 177 VTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 239 SAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASSTRAA--DRKSQVGTGDrseRIRTYNF-PQGRVT 315
Cdd:TIGR00020 257 SAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAkeGEKSEIGWGS---QIRSYVLhPYSMVK 333

                         330       340
                  ....*....|....*....|....*..
gi 2541256199 316 DHRINLTLYKIDRVMQGEMDEIIDALI 342
Cdd:TIGR00020 334 DLRTGYETGNVQAVLDGDIDQFIEAYL 360
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 46-340 2.16e-66

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 212.21  E-value: 2.16e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  46 VEAQVTALRQAETSLADAQALLLDPEM---KDLAEAEIAEL---RAHLPALEHEVRLAllprDEADARAGILEIRPAAGG 119
Cdd:PRK08787    2 LEKTVIGIADVLSGLADAGELLDLAESeqdEDTALAVIADLdkyQAHVEKLEFQRMFS----GQMDGANAFVDIQAGAGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 120 DEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSVFAKLKFESGVHRVQRVPATETQGRIHTSTI 199
Cdd:PRK08787   78 TEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 200 TVAVLPEAEE-VDVAINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDA 278
Cdd:PRK08787  158 SVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYEL 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2541256199 279 --QRHAASSTRAADRKSQVGTGdrsERIRTYNFPQGRVTDHRINLTLYKIDRVMQGEMDEIIDA 340
Cdd:PRK08787  238 evQKRNAEKDALEATKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 208-318 5.15e-66

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 203.81  E-value: 5.15e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 208 EEVDVAINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQHKNRAKAMKILRSRLYDAQRHAASStR 287
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEE-K 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2541256199 288 AADRKSQVGTGDRSERIRTYNF-PQGRVTDHR 318
Cdd:pfam00472  80 KRRIKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 35-344 1.57e-63

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 205.50  E-value: 1.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  35 KASKELSELEPVEAQVTALRQAETSLADAQALLL------DPEMKDLAEAEIAELRAHLPALEHEVRLAllprDEADARA 108
Cdd:PRK07342   14 EAQKLMRERQQLDDSINGINHLEQTLNDNIELIAmgeeegDKSIVEDAEKTIRDLKDEIDRRQIDALLS----GEADAND 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 109 GILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSVFAKLKFESGVHRVQRVPAT 188
Cdd:PRK07342   90 TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 189 ETQGRIHTSTITVAVLPEAEE-VDVAINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQHKNRAKA 267
Cdd:PRK07342  170 DSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 268 MKILRSRLYDAQ---RHAASSTRAADrKSQVGTGdrsERIRTYNF-PQGRVTDHRINLTLYKIDRVMQGEMDEIIDALIA 343
Cdd:PRK07342  250 WSMLRARLYEEElkkREEATNAAAAS-KTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAALA 325


                  .
gi 2541256199 344 E 344
Cdd:PRK07342  326 H 326
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 35-340 1.99e-60

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 196.95  E-value: 1.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  35 KASKELSELEPVEAQVTALRQAETSLADAQAL--LLDPEMKDLAEAEIAELRAhlpaLEHEV---RLALLPRDEADARAG 109
Cdd:PRK05589   12 EAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLceMMSEEDDEMKKEIISEVKN----IKEEIdrfKIETLLSGEYDRNNA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 110 ILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSVFAKLKFESGVHRVQRVPATE 189
Cdd:PRK05589   88 ILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 190 TQGRIHTSTITVAVLPE-AEEVDVAINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQHKNRAKAM 268
Cdd:PRK05589  168 ANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAM 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2541256199 269 KILRSRLYDAQRhaasstRAADRKSQVGTGDRSE-----RIRTYNF-PQGRVTDHRINLTLYKIDRVMQGEMDEIIDA 340
Cdd:PRK05589  248 KMLKSKLVELKE------RAHKEKIEDLTGELKDmgwgsQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFITQ 319
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 36-342 3.24e-56

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 186.09  E-value: 3.24e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199  36 ASKELSELEPVEAQVTALRQAETSLAD---AQALLLDPEMKDLAEAEIAELRAHLPALeHEVRLALLPRDEADARAGILE 112
Cdd:PRK06746   13 AQAVINEANALKDMVGKFRQLDETFENleiTHELLKEEYDEDLHEELESEVKGLIQEM-NEYELQLLLSDPYDKNNAILE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 113 IRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGIKGAMAEITGRSVFAKLKFESGVHRVQRVPATETQG 192
Cdd:PRK06746   92 LHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 193 RIHTSTITVAVLPE-AEEVDVAINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQHKNRAKAMKIL 271
Cdd:PRK06746  172 RRHTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKML 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2541256199 272 RSRLYDAQRHAASSTRAADRKSQVGTGDRSErIRTYNF-PQGRVTDHRINLTLYKIDRVMQGEMDEIIDALI 342
Cdd:PRK06746  252 KAKLYQKKLEEQQAELDEIRGEQKEIGWGSQ-IRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYL 322
PCRF smart00937
This domain is found in peptide chain release factors;
69-176 5.24e-41

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 139.52  E-value: 5.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199   69 DPEMKDLAEAEIAELRAHL-PALEHEVRLALLPRDEADARAGILEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVL 147
Cdd:smart00937   8 DDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKVEVL 87

                           90       100
                   ....*....|....*....|....*....
gi 2541256199  148 EYDESELGGIKGAMAEITGRSVFAKLKFE 176
Cdd:smart00937  88 DESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 211-318 1.86e-35

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 126.01  E-value: 1.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 211 DVAINDSDLRIDVYRASGAGGQHVNKTESAVRITH------------IPSGIVVAMQEERSQHKNRAKAMKILRSRLYDA 278
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2541256199 279 -----QRHAASSTRAAdrKSQVGTGDrseRIRtynfpqGRVTDHR 318
Cdd:COG1186   100 elepkERRATKPTRGS--KKRRLWGK---QIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 111-291 6.44e-28

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 107.94  E-value: 6.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 111 LEIRPAAGGDEAGLFAAELFAAYQKYAALQGWRFEVLEYDESELGGikgamaeiTGRSVFAKLKFESGVHRVQRVPAT-- 188
Cdd:TIGR03072   3 LQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPG--------TLRSALVSLDGEAAAALADRWEGTll 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 189 ---ETQGRIHTST----ITVAVLPEAEEvdvaINDSDLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVAMQEERSQH 261
Cdd:TIGR03072  75 wicPSPYRPHHRRknwfIGVQRFSASEE----ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQH 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 2541256199 262 KNRAKAMKILRSRLYDAQRHAASSTRAADR 291
Cdd:TIGR03072 151 ANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
211-292 1.97e-10

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 58.24  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541256199 211 DVAINDSDLRIDVYRASGAGGQHVNKTESAV-------------------------RIThiPSG-IVVAMQEERSQHKNR 264
Cdd:PRK09256    7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerllalaghRIT--KDGvIVIKAQEFRSQERNR 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2541256199 265 AKAMKILRSRLYDA-----QRHAASSTRAADRK 292
Cdd:PRK09256   85 EDALERLVALIREAlkppkKRRATKPTRGSKER 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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