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Conserved domains on  [gi|2541334991|ref|WP_297443161|]
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glycosyltransferase [Acidocella sp.]

Protein Classification

GT_2_like_c and Glyco_trans_1_4 domain-containing protein( domain architecture ID 10135616)

GT_2_like_c and Glyco_trans_1_4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
356-619 7.59e-36

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 134.74  E-value: 7.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 356 PVVSVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCAGLTLLRLGENIGFLKAANLALAHARA 433
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELlaALAFPRVRVIRNPENLGFAAARNLGLRAAGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 434 PAVLYLNNDIElgfgavaaalarlraaPDIGAVcakvvrthGRLQEAGGMiwrdgttsgylrdgaplapeanfvrdvafg 513
Cdd:COG1216    83 DYLLFLDDDTV----------------VEPDWL--------ERLLAAACL------------------------------ 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 514 sgvflLCRTGAVQALGGFDEDYaPAYYEDVDLCVRLRAAGLRVVYDPAVTLTHMEFGSAvTAEASMALMRRARRIFRHKH 593
Cdd:COG1216   109 -----LIRREVFEEVGGFDERF-FLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGGASS-GPLLRAYYLGRNRLLFLRKH 181

                         250       260
                  ....*....|....*....|....*.
gi 2541334991 594 EGILAGLpeasaAGALRARSVSGRRR 619
Cdd:COG1216   182 GPRPLLR-----LALLRGLRLRLRGR 202
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
806-943 1.89e-15

Glycosyl transferases group 1;


:

Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 74.08  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 806 LLFVGAVHqedsPNLDSLRWYVaEILPELAA--------LMGTPPVLHVAGHVAagqGLDIAspfVVAHGEVADLAPLYA 877
Cdd:pfam13692   4 ILFVGRLH----PNVKGVDYLL-EAVPLLRKrdndvrlvIVGDGPEEELEELAA---GLEDR---VIFTGFVEDLAELLA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2541334991 878 RARVFVAPTRFaAGTPYKIYEAVAFGVPVVASDLLA-GQLGWGDELLSAPVHDAAGFARQIARLYGD 943
Cdd:pfam13692  73 AADVFVLPSLY-EGFGLKLLEAMAAGLPVVATDVGGiPELVDGENGLLVPPGDPEALAEAILRLLED 138
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 619-975 3.84e-15

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03801:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 366  Bit Score: 78.35  E-value: 3.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 619 RVLFIeDTVPLRRLGSGFVRAHDIVRAMAAAGWEVQVLPLNGAPYDVMSLYGALPEGVEVLADREFTQAETFFAERGGI- 697
Cdd:cd03801     1 KILLL-SPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 698 ---YDLVWVSRTHNFRRLWPWLKGLKARLVVDSEAVAANRAAARAALRGEVfdagvaVKAEFAGLPRRAVVLAVNEAEAA 774
Cdd:cd03801    80 lrkFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRL------LARAEALLRRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 775 QIRGTGH---KRVSVLGTGRGLCLGATGFGAREG-------LLFVGAVHQEDSPNLdslrwyVAEILPELAAlMGTPPVL 844
Cdd:cd03801   154 ELRALGGippEKIVVIPNGVDLERFSPPLRRKLGippdrpvLLFVGRLSPRKGVDL------LLEALAKLLR-RGPDVRL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 845 HVAGHV-----AAGQGLDIASPFVVAHGEV--ADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQ 915
Cdd:cd03801   227 VIVGGDgplraELEELELGLGDRVRFLGFVpdEELPALYAAADVFVLPSRYE-GFGLVVLEAMAAGLPVVATDVggLPEV 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 916 LGWGDELLSAPVHDAAGFARQIARLYGDEALWVACRERAAARLVAEHDPAVFAARVAEIL 975
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
356-619 7.59e-36

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 134.74  E-value: 7.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 356 PVVSVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCAGLTLLRLGENIGFLKAANLALAHARA 433
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELlaALAFPRVRVIRNPENLGFAAARNLGLRAAGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 434 PAVLYLNNDIElgfgavaaalarlraaPDIGAVcakvvrthGRLQEAGGMiwrdgttsgylrdgaplapeanfvrdvafg 513
Cdd:COG1216    83 DYLLFLDDDTV----------------VEPDWL--------ERLLAAACL------------------------------ 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 514 sgvflLCRTGAVQALGGFDEDYaPAYYEDVDLCVRLRAAGLRVVYDPAVTLTHMEFGSAvTAEASMALMRRARRIFRHKH 593
Cdd:COG1216   109 -----LIRREVFEEVGGFDERF-FLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGGASS-GPLLRAYYLGRNRLLFLRKH 181

                         250       260
                  ....*....|....*....|....*.
gi 2541334991 594 EGILAGLpeasaAGALRARSVSGRRR 619
Cdd:COG1216   182 GPRPLLR-----LALLRGLRLRLRGR 202
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 360-568 1.22e-35

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 132.68  E-value: 1.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 360 VIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDT-SRIELFCAGLTLLRLGENIGFLKAANLALAHARAPAVLY 438
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSvELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 439 LNNDIELGFGAVAAALARLRAAPDIGAVCAKVvrthgrlqeaggmiwrdgttsgylrdgaplapeanfvrdvafgSGVFL 518
Cdd:cd04186    81 LNPDTVVEPGALLELLDAAEQDPDVGIVGPKV-------------------------------------------SGAFL 117

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2541334991 519 LCRTGAVQALGGFDEDYAPaYYEDVDLCVRLRAAGLRVVYDPAVTLTHME 568
Cdd:cd04186   118 LVRREVFEEVGGFDEDFFL-YYEDVDLCLRARLAGYRVLYVPQAVIYHHG 166
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
806-943 1.89e-15

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 74.08  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 806 LLFVGAVHqedsPNLDSLRWYVaEILPELAA--------LMGTPPVLHVAGHVAagqGLDIAspfVVAHGEVADLAPLYA 877
Cdd:pfam13692   4 ILFVGRLH----PNVKGVDYLL-EAVPLLRKrdndvrlvIVGDGPEEELEELAA---GLEDR---VIFTGFVEDLAELLA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2541334991 878 RARVFVAPTRFaAGTPYKIYEAVAFGVPVVASDLLA-GQLGWGDELLSAPVHDAAGFARQIARLYGD 943
Cdd:pfam13692  73 AADVFVLPSLY-EGFGLKLLEAMAAGLPVVATDVGGiPELVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 619-975 3.84e-15

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 78.35  E-value: 3.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 619 RVLFIeDTVPLRRLGSGFVRAHDIVRAMAAAGWEVQVLPLNGAPYDVMSLYGALPEGVEVLADREFTQAETFFAERGGI- 697
Cdd:cd03801     1 KILLL-SPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 698 ---YDLVWVSRTHNFRRLWPWLKGLKARLVVDSEAVAANRAAARAALRGEVfdagvaVKAEFAGLPRRAVVLAVNEAEAA 774
Cdd:cd03801    80 lrkFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRL------LARAEALLRRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 775 QIRGTGH---KRVSVLGTGRGLCLGATGFGAREG-------LLFVGAVHQEDSPNLdslrwyVAEILPELAAlMGTPPVL 844
Cdd:cd03801   154 ELRALGGippEKIVVIPNGVDLERFSPPLRRKLGippdrpvLLFVGRLSPRKGVDL------LLEALAKLLR-RGPDVRL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 845 HVAGHV-----AAGQGLDIASPFVVAHGEV--ADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQ 915
Cdd:cd03801   227 VIVGGDgplraELEELELGLGDRVRFLGFVpdEELPALYAAADVFVLPSRYE-GFGLVVLEAMAAGLPVVATDVggLPEV 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 916 LGWGDELLSAPVHDAAGFARQIARLYGDEALWVACRERAAARLVAEHDPAVFAARVAEIL 975
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 875-975 1.23e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 68.48  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 875 LYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSAPVHDAAGFARQIARLYGDEALWVACRE 952
Cdd:COG0438    17 LLAAADVFVLPSRSE-GFGLVLLEAMAAGLPVIATDVggLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                          90       100
                  ....*....|....*....|...
gi 2541334991 953 RAAARLVAEHDPAVFAARVAEIL 975
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALY 118
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 841-966 4.03e-11

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 65.81  E-value: 4.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 841 PPVLHVAGHvaaGQGLDIAS----PFVVAHGEV--ADLAPLYARARVFVAPTRFAAGTPYKIYEAVAFGVPVVASDLLAG 914
Cdd:cd03823   220 DIELVIAGH---GPLSDERQieggRRIAFLGRVptDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLGGI 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2541334991 915 QLGWGDELLS--APVHDAAGFARQIARLYGDEALWVacRERAAARLVAEHDPAV 966
Cdd:cd03823   297 AELIQPGVNGllFAPGDAEDLAAAMRRLLTDPALLE--RLRAGAEPPRSTESQA 348
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 359-445 6.15e-11

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 62.03  E-value: 6.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 359 SVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCA--GLTLLRLGENIGFLKAANLALAHARAP 434
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIaeEYAKKdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90
                  ....*....|.
gi 2541334991 435 AVLYLNNDIEL 445
Cdd:pfam00535  81 YIAFLDADDEV 91
mycofact_glyco TIGR03965
mycofactocin system glycosyltransferase; Members of this protein family are putative ...
 355-566 4.12e-10

mycofactocin system glycosyltransferase; Members of this protein family are putative glycosyltransferases, members of pfam00535 (glycosyl transferase family 2). Members appear mostly in the Actinobacteria, where they appear to be part of a system for converting a precursor peptide (TIGR03969) into a novel redox carrier designated mycofactocin. A radical SAM enzyme, TIGR03962, is a proposed to be a key maturase for mycofactocin.


Pssm-ID: 274884 [Multi-domain]  Cd Length: 466  Bit Score: 63.24  E-value: 4.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 355 PPVVSVIMVAHNRFELTMQALASLRQNF--AGPMQVVLADNGSTDDTSRIELFCAGLTL--LRLGENIGFLKAANLALAH 430
Cdd:TIGR03965  73 PPSVTVVVPVRNRPAGLARLLAALLALDypRDRLEVIVVDDGSEDPVPTRAARGARLPVrvIRHPRRQGPAAARNAGARA 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 431 ARAPAVLYLNNDIELGFGAVAAALARLRAaPDIGAVCAKVVRthgrLQEAGGMIWRDGTTSGYL---RDGAPLAPEANfv 507
Cdd:TIGR03965 153 ARTEFVAFTDSDVVPRPGWLRALLAHFDD-PGVALVAPRVVA----LPAADTRLARYEAVRSSLdlgPEEAVVRPRGP-- 225

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2541334991 508 rdVAFGSGVFLLCRTGAVQALGGFDEDYAPAyyEDVDLCVRLRAAGLRVVYDPAVTLTH 566
Cdd:TIGR03965 226 --VSYVPSAALLVRRRALLEVGGFDERLEVG--EDVDLCWRLCEAGGRVRYEPAAVVAH 280
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
356-619 7.59e-36

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 134.74  E-value: 7.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 356 PVVSVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCAGLTLLRLGENIGFLKAANLALAHARA 433
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELlaALAFPRVRVIRNPENLGFAAARNLGLRAAGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 434 PAVLYLNNDIElgfgavaaalarlraaPDIGAVcakvvrthGRLQEAGGMiwrdgttsgylrdgaplapeanfvrdvafg 513
Cdd:COG1216    83 DYLLFLDDDTV----------------VEPDWL--------ERLLAAACL------------------------------ 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 514 sgvflLCRTGAVQALGGFDEDYaPAYYEDVDLCVRLRAAGLRVVYDPAVTLTHMEFGSAvTAEASMALMRRARRIFRHKH 593
Cdd:COG1216   109 -----LIRREVFEEVGGFDERF-FLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGGASS-GPLLRAYYLGRNRLLFLRKH 181

                         250       260
                  ....*....|....*....|....*.
gi 2541334991 594 EGILAGLpeasaAGALRARSVSGRRR 619
Cdd:COG1216   182 GPRPLLR-----LALLRGLRLRLRGR 202
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 360-568 1.22e-35

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 132.68  E-value: 1.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 360 VIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDT-SRIELFCAGLTLLRLGENIGFLKAANLALAHARAPAVLY 438
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSvELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 439 LNNDIELGFGAVAAALARLRAAPDIGAVCAKVvrthgrlqeaggmiwrdgttsgylrdgaplapeanfvrdvafgSGVFL 518
Cdd:cd04186    81 LNPDTVVEPGALLELLDAAEQDPDVGIVGPKV-------------------------------------------SGAFL 117

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2541334991 519 LCRTGAVQALGGFDEDYAPaYYEDVDLCVRLRAAGLRVVYDPAVTLTHME 568
Cdd:cd04186   118 LVRREVFEEVGGFDEDFFL-YYEDVDLCLRARLAGYRVLYVPQAVIYHHG 166
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
806-943 1.89e-15

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 74.08  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 806 LLFVGAVHqedsPNLDSLRWYVaEILPELAA--------LMGTPPVLHVAGHVAagqGLDIAspfVVAHGEVADLAPLYA 877
Cdd:pfam13692   4 ILFVGRLH----PNVKGVDYLL-EAVPLLRKrdndvrlvIVGDGPEEELEELAA---GLEDR---VIFTGFVEDLAELLA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2541334991 878 RARVFVAPTRFaAGTPYKIYEAVAFGVPVVASDLLA-GQLGWGDELLSAPVHDAAGFARQIARLYGD 943
Cdd:pfam13692  73 AADVFVLPSLY-EGFGLKLLEAMAAGLPVVATDVGGiPELVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 619-975 3.84e-15

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 78.35  E-value: 3.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 619 RVLFIeDTVPLRRLGSGFVRAHDIVRAMAAAGWEVQVLPLNGAPYDVMSLYGALPEGVEVLADREFTQAETFFAERGGI- 697
Cdd:cd03801     1 KILLL-SPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 698 ---YDLVWVSRTHNFRRLWPWLKGLKARLVVDSEAVAANRAAARAALRGEVfdagvaVKAEFAGLPRRAVVLAVNEAEAA 774
Cdd:cd03801    80 lrkFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRL------LARAEALLRRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 775 QIRGTGH---KRVSVLGTGRGLCLGATGFGAREG-------LLFVGAVHQEDSPNLdslrwyVAEILPELAAlMGTPPVL 844
Cdd:cd03801   154 ELRALGGippEKIVVIPNGVDLERFSPPLRRKLGippdrpvLLFVGRLSPRKGVDL------LLEALAKLLR-RGPDVRL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 845 HVAGHV-----AAGQGLDIASPFVVAHGEV--ADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQ 915
Cdd:cd03801   227 VIVGGDgplraELEELELGLGDRVRFLGFVpdEELPALYAAADVFVLPSRYE-GFGLVVLEAMAAGLPVVATDVggLPEV 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 916 LGWGDELLSAPVHDAAGFARQIARLYGDEALWVACRERAAARLVAEHDPAVFAARVAEIL 975
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 875-975 1.23e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 68.48  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 875 LYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSAPVHDAAGFARQIARLYGDEALWVACRE 952
Cdd:COG0438    17 LLAAADVFVLPSRSE-GFGLVLLEAMAAGLPVIATDVggLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                          90       100
                  ....*....|....*....|...
gi 2541334991 953 RAAARLVAEHDPAVFAARVAEIL 975
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALY 118
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 355-560 2.98e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 69.73  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 355 PPVVSVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI-ELFCAG---LTLLRLGENIGFLKAANLALAH 430
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEIlRELAAKdprIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 431 ARAPAVLYLNNDIELgfgavaaalarlraAPDIGAVCAKVVRTHGRLQEAGGMIWRDGtTSGYLRDGAPLAPEANFVRDV 510
Cdd:COG0463    81 ARGDYIAFLDADDQL--------------DPEKLEELVAALEEGPADLVYGSRLIREG-ESDLRRLGSRLFNLVRLLTNL 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2541334991 511 AFGSGVFLLCRTGAVQALgGFDEDyapaYYEDVDLcVRLRAAGLRVVYDP 560
Cdd:COG0463   146 PDSTSGFRLFRREVLEEL-GFDEG----FLEDTEL-LRALRHGFRIAEVP 189
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 340-566 5.31e-13

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 70.93  E-value: 5.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 340 LALFARQRLEFGEQAPPVVSVIMVAHNRFELTMQALASL-RQNF-AGPMQVVLADNGSTDDTSRI----ELFCAGLTLLR 413
Cdd:COG1215    13 LLLLALARRRRAPADLPRVSVIIPAYNEEAVIEETLRSLlAQDYpKEKLEVIVVDDGSTDETAEIarelAAEYPRVRVIE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 414 LGENIGFLKAANLALAHARAPAVLYLNNDIELgfgavaaalarlraapdigavcakvvrTHGRLQEAggmiwrdgttSGY 493
Cdd:COG1215    93 RPENGGKAAALNAGLKAARGDIVVFLDADTVL---------------------------DPDWLRRL----------VAA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2541334991 494 LRDgaplapeanfvRDVAFgSGVFLLCRTGAVQALGGFDEDyapAYYEDVDLCVRLRAAGLRVVYDPAVTLTH 566
Cdd:COG1215   136 FAD-----------PGVGA-SGANLAFRREALEEVGGFDED---TLGEDLDLSLRLLRAGYRIVYVPDAVVYE 193
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 841-966 4.03e-11

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 65.81  E-value: 4.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 841 PPVLHVAGHvaaGQGLDIAS----PFVVAHGEV--ADLAPLYARARVFVAPTRFAAGTPYKIYEAVAFGVPVVASDLLAG 914
Cdd:cd03823   220 DIELVIAGH---GPLSDERQieggRRIAFLGRVptDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLGGI 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2541334991 915 QLGWGDELLS--APVHDAAGFARQIARLYGDEALWVacRERAAARLVAEHDPAV 966
Cdd:cd03823   297 AELIQPGVNGllFAPGDAEDLAAAMRRLLTDPALLE--RLRAGAEPPRSTESQA 348
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 359-445 6.15e-11

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 62.03  E-value: 6.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 359 SVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCA--GLTLLRLGENIGFLKAANLALAHARAP 434
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIaeEYAKKdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90
                  ....*....|.
gi 2541334991 435 AVLYLNNDIEL 445
Cdd:pfam00535  81 YIAFLDADDEV 91
mycofact_glyco TIGR03965
mycofactocin system glycosyltransferase; Members of this protein family are putative ...
 355-566 4.12e-10

mycofactocin system glycosyltransferase; Members of this protein family are putative glycosyltransferases, members of pfam00535 (glycosyl transferase family 2). Members appear mostly in the Actinobacteria, where they appear to be part of a system for converting a precursor peptide (TIGR03969) into a novel redox carrier designated mycofactocin. A radical SAM enzyme, TIGR03962, is a proposed to be a key maturase for mycofactocin.


Pssm-ID: 274884 [Multi-domain]  Cd Length: 466  Bit Score: 63.24  E-value: 4.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 355 PPVVSVIMVAHNRFELTMQALASLRQNF--AGPMQVVLADNGSTDDTSRIELFCAGLTL--LRLGENIGFLKAANLALAH 430
Cdd:TIGR03965  73 PPSVTVVVPVRNRPAGLARLLAALLALDypRDRLEVIVVDDGSEDPVPTRAARGARLPVrvIRHPRRQGPAAARNAGARA 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 431 ARAPAVLYLNNDIELGFGAVAAALARLRAaPDIGAVCAKVVRthgrLQEAGGMIWRDGTTSGYL---RDGAPLAPEANfv 507
Cdd:TIGR03965 153 ARTEFVAFTDSDVVPRPGWLRALLAHFDD-PGVALVAPRVVA----LPAADTRLARYEAVRSSLdlgPEEAVVRPRGP-- 225

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2541334991 508 rdVAFGSGVFLLCRTGAVQALGGFDEDYAPAyyEDVDLCVRLRAAGLRVVYDPAVTLTH 566
Cdd:TIGR03965 226 --VSYVPSAALLVRRRALLEVGGFDERLEVG--EDVDLCWRLCEAGGRVRYEPAAVVAH 280
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 360-468 5.83e-10

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 59.06  E-value: 5.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 360 VIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRIELFCAGL----TLLRLGENIGFLKAANLALAHARAPA 435
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKdprvIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2541334991 436 VLYLNNDIELGFGAVAAALARLRAAPDIGAVCA 468
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 360-534 8.82e-09

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 56.08  E-value: 8.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 360 VIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELFCAG---LTLLRLGENIGflKAANL--ALAHAR 432
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEIleELAALYirrVLVVRDKENGG--KAGALnaGLRHAK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 433 APAVLYLNNDIELGFGAVAAALARLRAAPDIGAVCAKVV------RTHGRLQEAGGMIWRDGTTSGYLRDGAPLAPeanf 506
Cdd:cd06423    79 GDIVVVLDADTILEPDALKRLVVPFFADPKVGAVQGRVRvrngseNLLTRLQAIEYLSIFRLGRRAQSALGGVLVL---- 154

                         170       180
                  ....*....|....*....|....*...
gi 2541334991 507 vrdvafgSGVFLLCRTGAVQALGGFDED 534
Cdd:cd06423   155 -------SGAFGAFRREALREVGGWDED 175
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 866-963 1.01e-07

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 55.29  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 866 HGEVADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL-------LAGQLGwgdelLSAPVHDAAGFARQIA 938
Cdd:cd03808   251 LGFRSDVPELLAESDVFVLPSYRE-GLPRSLLEAMAAGRPVITTDVpgcrelvIDGVNG-----FLVPPGDVEALADAIE 324

                          90       100
                  ....*....|....*....|....*
gi 2541334991 939 RLYGDEALWVACRERAAARLVAEHD 963
Cdd:cd03808   325 KLIEDPELRKEMGEAARKRVEEKFD 349
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 388-571 3.32e-07

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 52.29  E-value: 3.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 388 VVLADNGST-DDTSRIELFCAGLTLLRLGENIGFLKAANLALAHA---RAPAVLYLNNDIELG---FGAVAAALARLRAA 460
Cdd:cd02526    27 VVVVDNSSGnDIELRLRLNSEKIELIHLGENLGIAKALNIGIKAAlenGADYVLLFDQDSVPPpdmVEKLLAYKILSDKN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 461 PDIGAVCAKVVrtHGRLQEAGGMIwrdgTTSGYLRDGAPLAPEAnfVRDVAFG--SGVFLlcRTGAVQALGGFDEDYAPA 538
Cdd:cd02526   107 SNIGAVGPRII--DRRTGENSPGV----RKSGYKLRIQKEGEEG--LKEVDFLitSGSLI--SLEALEKVGGFDEDLFID 176

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2541334991 539 YYeDVDLCVRLRAAGLRVVYDPAVTLTHmEFGS 571
Cdd:cd02526   177 YV-DTEWCLRARSKGYKIYVVPDAVLKH-ELGD 207
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
881-975 6.58e-06

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 45.29  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 881 VFVAPTRFAAGTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSApvHDAAGFARQIARLYGDEALWVACRERAAARL 958
Cdd:pfam13524   1 IVLNPSRRPDSPNMRVFEAAACGAPLLTDRTpgLEELFEPGEEILLY--RDPEELAEKIRYLLEHPEERRAIAAAGRERV 78

                          90
                  ....*....|....*..
gi 2541334991 959 VAEHDPavfAARVAEIL 975
Cdd:pfam13524  79 LAEHTY---AHRAEQLL 92
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 870-958 1.59e-05

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 48.13  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 870 ADLAPLYARARVFVAPTRFAA-GTPykIYEAVAFGVPVVASDL-----LAGqlgwGDELLSAPvHDAAGFARQIARLYGD 943
Cdd:cd03809   261 EDLPALYRGARAFVFPSLYEGfGLP--VLEAMACGTPVIASNIsvlpeVAG----DAALYFDP-LDPESIADAILRLLED 333

                          90
                  ....*....|....*
gi 2541334991 944 EALWVACRERAAARL 958
Cdd:cd03809   334 PSLREELIRKGLERA 348
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 871-957 2.48e-05

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 45.34  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 871 DLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSAPVHDAAGFARQIARLYGDEALWV 948
Cdd:pfam00534  71 DLPELLKIADVFVLPSRYE-GFGIVLLEAMACGLPVIASDVggPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRE 149


                  ....*....
gi 2541334991 949 ACRERAAAR 957
Cdd:pfam00534 150 RLGENARKR 158
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 870-972 3.76e-05

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 47.34  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 870 ADLAPLYARARVFVAPTR----FAAGTPYKIYEAVAFGVPVVASDllagqLGWGDEL-------LSAPVHDAAGFARQIA 938
Cdd:cd03794   283 EEVPELLSAADVGLVPLKdnpaNRGSSPSKLFEYMAAGKPILASD-----DGGSDLAveingcgLVVEPGDPEALADAIL 357

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2541334991 939 RLYGDEALWVACRERAAARLVAEHDPAVFAARVA 972
Cdd:cd03794   358 ELLDDPELRRAMGENGRELAEEKFSREKLADRLL 391
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 863-962 1.05e-04

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 45.69  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 863 VVAHGEVADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDLLAG--QLGWGDE--LLsAPVHDAAGFARQIA 938
Cdd:cd03820   240 VKLLGPTKNIAEEYANSSIFVLSSRYE-GFPMVLLEAMAYGLPIISFDCPTGpsEIIEDGEngLL-VPNGDVDALAEALL 317

                          90       100
                  ....*....|....*....|....*.
gi 2541334991 939 RLYGDEALwvacRER--AAARLVAEH 962
Cdd:cd03820   318 RLMEDEEL----RKKmgKNARKNAER 339
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 340-588 1.21e-04

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 44.88  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 340 LALFARQRLEFGEQAP----PVVSVIMVAHN---RFELTMQALASLRQnfagP---MQVVLADNGSTDDTSRI-ELFCA- 407
Cdd:cd06439     9 LKLLARLRPKPPSLPDpaylPTVTIIIPAYNeeaVIEAKLENLLALDY----PrdrLEIIVVSDGSTDGTAEIaREYADk 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 408 GLTLLRLGENIGFLKAANLALAHARAPAVL------YLNNDIELgfgavaaALARLRAAPDIGAVCA-KVVRTHGRLQEA 480
Cdd:cd06439    85 GVKLLRFPERRGKAAALNRALALATGEIVVftdanaLLDPDALR-------LLVRHFADPSVGAVSGeLVIVDGGGSGSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 481 GGMIWRdgttsgYlrdgaplapeANFVR--DVAFGS-----GVFLLCRTGAVQalgGFDEDYAPayyEDVDLCVRLRAAG 553
Cdd:cd06439   158 EGLYWK------Y----------ENWLKraESRLGStvganGAIYAIRRELFR---PLPADTIN---DDFVLPLRIARQG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2541334991 554 LRVVYDPAVTLthMEfgsAVTAEASMALMRRARRI 588
Cdd:cd06439   216 YRVVYEPDAVA--YE---EVAEDGSEEFRRRVRIA 245
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 842-975 3.84e-04

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 43.91  E-value: 3.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 842 PVLHVAGH---------VAAGQGLDIASPFVVA--HGEVADLaplYARARVFVAPTRfAAGTPYKIYEAVAFGVPVVASD 910
Cdd:cd03798   232 VVLLIVGDgplrealraLAEDLGLGDRVTFTGRlpHEQVPAY---YRACDVFVLPSR-HEGFGLVLLEAMACGLPVVATD 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2541334991 911 lLAGQ---LGWGDELLSAPVHDAAGFARQIARLYgDEALWVACRERAAARLVAEHDPAVFAARVAEIL 975
Cdd:cd03798   308 -VGGIpevVGDPETGLLVPPGDADALAAALRRAL-AEPYLRELGEAARARVAERFSWVKAADRIAAAY 373
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 358-563 3.86e-04

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 42.94  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 358 VSVIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTsrIELFCAGLTLLRLGEnIGFLKAANLALAHARAPAVL 437
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGT--VAIARSAGVVVISSP-KGRARQMNAGAAAARGDWLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 438 YLNNDIELGFGAVAAALARLRAAPDIGAvcakvvrtHGRLQ-EAGGMIWRDGTTSGYLRdgaplapeANFVRdVAFGSGV 516
Cdd:cd02522    78 FLHADTRLPPDWDAAIIETLRADGAVAG--------AFRLRfDDPGPRLRLLELGANLR--------SRLFG-LPYGDQG 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2541334991 517 FLLCRTgAVQALGGFDEDYapaYYEDVDLCVRLRAAG-LRVVYDPAVT 563
Cdd:cd02522   141 LFIRRE-LFEELGGFPELP---LMEDVELVRRLRRRGrPALLPSPVTT 184
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 509-590 3.96e-04

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 42.71  E-value: 3.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 509 DVAFGSGVFLLCRTGAVQALGGFDEDyapAYYEDVDLCVRLRAAGLRVVYDPAVtLTHMEFGSAVTAEasmalMRRARRI 588
Cdd:pfam13632  68 RVLPFVGSGAFLRRSALQEVGGWDDG---SVSEDFDFGLRLQRAGYRVRFAPYS-AVYEKSPLTFRDF-----LRQRRRW 138


                  ..
gi 2541334991 589 FR 590
Cdd:pfam13632 139 AY 140
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 867-963 5.42e-04

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 43.46  E-value: 5.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 867 GEVADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASD------LLAGQLGWGdellsAPVHDAAGFARQIARL 940
Cdd:cd03807   253 GERSDVPALLPAMDIFVLSSRTE-GFPNALLEAMACGLPVVATDvggaaeLVDDGTGFL-----VPAGDPQALADAIRAL 326

                          90       100
                  ....*....|....*....|...
gi 2541334991 941 YGDEALWVACRERAAARLVAEHD 963
Cdd:cd03807   327 LEDPEKRARLGRAARERIANEFS 349
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 510-575 7.17e-04

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 42.36  E-value: 7.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2541334991 510 VAFGSGVFLLCRTGAVQALGGFDEDYAPAyyEDVDLCVRLRAAGLRVVYDPAVTLTHmEFGSAVTA 575
Cdd:pfam13641 157 VLPLSGAGSAIRREVLKELGLFDPFFLLG--DDKSLGRRLRRHGWRVAYAPDAAVRT-VFPTYLAA 219
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 856-956 7.20e-04

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 43.12  E-value: 7.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 856 LDIAsPFVVAHGEVADLAPLYARARVFVAPTRFAaGTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSAPVHDAAGF 933
Cdd:cd03811   241 LGLA-ERVIFLGFQSNPYPYLKKADLFVLSSRYE-GFPNVLLEAMALGTPVVSTDCpgPREILDDGENGLLVPDGDAAAL 318

                          90       100
                  ....*....|....*....|...
gi 2541334991 934 ARQIARLYGDEALwVACRERAAA 956
Cdd:cd03811   319 AGILAALLQKKLD-AALRERLAK 340
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 360-442 1.40e-03

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 41.01  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 360 VIMVAHN---RFELTMQ-ALASLRQNFAGPMQVVLADNGSTDDTSRI-----ELFCAGLTLLRLGENIGFLKAANLALAH 430
Cdd:cd04188     1 VVIPAYNeekRLPPTLEeAVEYLEERPSFSYEIIVVDDGSKDGTAEVarklaRKNPALIRVLTLPKNRGKGGAVRAGMLA 80

                          90
                  ....*....|..
gi 2541334991 431 ARAPAVLYLNND 442
Cdd:cd04188    81 ARGDYILFADAD 92
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 870-960 1.84e-03

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 41.84  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 870 ADLAPLYARARVFVAPTRFAagtPYKI--YEAVAFGVPVVASD-------LLAGQLGwgdeLLSAPvHDAAGFARQIARL 940
Cdd:cd03800   294 DDLPELYRAADVFVVPSLYE---PFGLtaIEAMACGTPVVATAvgglqdiVRDGRTG----LLVDP-HDPEALAAALRRL 365

                          90       100
                  ....*....|....*....|
gi 2541334991 941 YGDEALWVACRERAAARLVA 960
Cdd:cd03800   366 LDDPALWQRLSRAGLERARA 385
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 360-419 1.94e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 40.70  E-value: 1.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2541334991 360 VIMVAHNRFELTMQALASLRQNFAGPMQVVLADNGSTDDTSRI--ELF-CAGLTLLRLGENIG 419
Cdd:cd04185     1 AVVVTYNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWltSLGdLDNIVYLRLPENLG 63
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 870-974 2.42e-03

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 41.28  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 870 ADLAPLYARARVFVAPTRFAA-----GTPYKIYEAVAFGVPVVASDL--LAGQLGWGDELLSAPVHDAAGFARQIARLYG 942
Cdd:cd05844   254 AEVQDWMRRAEIFCLPSVTAAsgdseGLGIVLLEAAACGVPVVSSRHggIPEAILDGETGFLVPEGDVDALADALQALLA 333

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2541334991 943 DEALWVACRERAAARLVAEHDPAVFAARVAEI 974
Cdd:cd05844   334 DRALADRMGGAARAFVCEQFDIRVQTAKLEAI 365
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 833-970 4.30e-03

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 40.39  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2541334991 833 ELAALMGTPP--VLHVAGHVAAgqgLDIASPF-VVAHGEVAD---LAPLYARARVFVAPTRfAAGTPYKIYEAVAFGVPV 906
Cdd:cd03825   215 EALKLLATKDdlLLVVFGKNDP---QIVILPFdIISLGYIDDdeqLVDIYSAADLFVHPSL-ADNLPNTLLEAMACGTPV 290

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2541334991 907 VASD-------LLAGQLGWgdellSAPVHDAAGFARQIARLYGDEALWVACRERAAARLVAEHDPAVFAAR 970
Cdd:cd03825   291 VAFDtggspeiVQHGVTGY-----LVPPGDVQALAEAIEWLLANPKERESLGERARALAENHFDQRVQAQR 356
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 891-957 5.54e-03

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 40.40  E-value: 5.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2541334991 891 GTPYKIYEAVAFGVPVVASD------LLAGQLgwgDELLSA----PVHDAAGFARQIARLYGDEALWVACRERAAAR 957
Cdd:cd03813   382 GQPLVILEAMASGVPVVATDvgscreLIYGAD---DALGQAglvvPPADPEALAEALIKLLRDPELRQAFGEAGRKR 455
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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