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Conserved domains on  [gi|2542594439|ref|WP_298554638|]
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flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [uncultured Streptomyces sp.]

Protein Classification

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase( domain architecture ID 10011395)

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, part of an alternative non-mevalonate pathway for isoprenoid biosynthesis

CATH:  3.30.413.10|3.20.20.20
EC:  1.17.7.-
Gene Ontology:  GO:0016114|GO:0046429|GO:0005506|GO:0051539|GO:0019288
SCOP:  4001495|4003972|4004884

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
11-370 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


:

Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 655.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  11 VPARPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 90
Cdd:PRK00366    1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  91 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVE 170
Cdd:PRK00366   81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 171 SALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVS 250
Cdd:PRK00366  161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 251 LSAPPAEEVKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLG 330
Cdd:PRK00366  241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2542594439 331 VASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAERM 370
Cdd:PRK00366  321 IAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
11-370 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 655.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  11 VPARPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 90
Cdd:PRK00366    1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  91 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVE 170
Cdd:PRK00366   81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 171 SALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVS 250
Cdd:PRK00366  161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 251 LSAPPAEEVKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLG 330
Cdd:PRK00366  241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2542594439 331 VASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAERM 370
Cdd:PRK00366  321 IAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
 14-374 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 614.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  14 RPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPV 93
Cdd:COG0821     3 SSPIPRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  94 IADIHFQPKYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESAL 173
Cdd:COG0821    83 VADIHFDYRLALEAAEAGVDKLRINPGNIG-SDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 174 WEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSA 253
Cdd:COG0821   162 EHARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 254 PPAEEVKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVAS 333
Cdd:COG0821   242 DPVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGPGEAKEADIGIAG 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2542594439 334 GNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAERMEQDG 374
Cdd:COG0821   322 GGGEGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEG 362
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
 22-362 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 585.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  22 SRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQP 101
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 102 KYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESALWEASLFEE 181
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIG-SEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 182 HGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEEVKV 261
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 262 GIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIF 341
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGEGLLF 319

                         330       340
                  ....*....|....*....|.
gi 2542594439 342 VKGEVIKTVPESKIVETLIEE 362
Cdd:pfam04551 320 KKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
 19-362 1.95e-150

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 428.77  E-value: 1.95e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  19 RRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIH 98
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  99 FQPKYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESALWEASL 178
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIG-FEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 179 FEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEE 258
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 259 VKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVA-SGNGK 337
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGPGEAKHADIGISgPGTGF 319

                         330       340
                  ....*....|....*....|....*
gi 2542594439 338 GQIFVKGEVIKTVPESKIVETLIEE 362
Cdd:TIGR00612 320 AWLFKHGKPKAKVPETDMVDELIKL 344
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
11-370 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 655.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  11 VPARPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 90
Cdd:PRK00366    1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  91 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVE 170
Cdd:PRK00366   81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 171 SALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVS 250
Cdd:PRK00366  161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 251 LSAPPAEEVKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLG 330
Cdd:PRK00366  241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2542594439 331 VASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAERM 370
Cdd:PRK00366  321 IAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
 14-374 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 614.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  14 RPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPV 93
Cdd:COG0821     3 SSPIPRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  94 IADIHFQPKYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESAL 173
Cdd:COG0821    83 VADIHFDYRLALEAAEAGVDKLRINPGNIG-SDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 174 WEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSA 253
Cdd:COG0821   162 EHARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 254 PPAEEVKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVAS 333
Cdd:COG0821   242 DPVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGPGEAKEADIGIAG 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2542594439 334 GNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAERMEQDG 374
Cdd:COG0821   322 GGGEGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEG 362
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
 22-362 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 585.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  22 SRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQP 101
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 102 KYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESALWEASLFEE 181
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIG-SEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 182 HGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEEVKV 261
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 262 GIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIF 341
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGEGLLF 319

                         330       340
                  ....*....|....*....|.
gi 2542594439 342 VKGEVIKTVPESKIVETLIEE 362
Cdd:pfam04551 320 KKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
 19-362 1.95e-150

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 428.77  E-value: 1.95e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  19 RRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIH 98
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  99 FQPKYVFAAIEAGCAAVRVNPGNIKqFDDRIKEIAQAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALVESALWEASL 178
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIG-FEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 179 FEEHGFRDIKISVKHNDPVVMIEAYRQLAESCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEE 258
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 259 VKVGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVA-SGNGK 337
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGPGEAKHADIGISgPGTGF 319

                         330       340
                  ....*....|....*....|....*
gi 2542594439 338 GQIFVKGEVIKTVPESKIVETLIEE 362
Cdd:TIGR00612 320 AWLFKHGKPKAKVPETDMVDELIKL 344
PRK00694 PRK00694
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
 12-267 3.03e-61

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated


Pssm-ID: 234812  Cd Length: 606  Bit Score: 207.38  E-value: 3.03e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  12 PARPLAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATI-----A 86
Cdd:PRK00694    5 PCIQNAFRRKTHPVRIGNLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLKEAQACEHIkerliQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  87 RKSQIPVIADIHFQPKyvfAAIE-AGCA-AVRVNPGNI--------------KQFDD---RIKE----IAQAAKDHGTPI 143
Cdd:PRK00694   85 QGISIPLVADIHFFPQ---AAMHvADFVdKVRINPGNYvdkrnmftgkiytdEQYAHsllRLEEkfspLVEKCKRLGKAM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 144 RIGVNAGSLDRRLLQKYGRaTPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESCD-----YPLHLGV 218
Cdd:PRK00694  162 RIGVNHGSLSERVMQRYGD-TIEGMVYSALEYIEVCEKLDYRDVVFSMKSSNPKVMVAAYRQLAKDLDargwlYPLHLGV 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2542594439 219 TEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEEVKVGIQILQ 267
Cdd:PRK00694  241 TEAGSGTDGIIKSAVGIGTLLSEGLGDTIRCSLTGCPTNEIPVCISLLK 289
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
 18-261 9.14e-59

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 200.83  E-value: 9.14e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  18 ERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATI-----ARKSQIP 92
Cdd:PRK02048    7 SRRKTSVVNIGATPLGGPNPIRIQSMTNTSTMDTEACVAQAKRIIDAGGEYVRLTTQGVREAENLMNIniglrSQGYMVP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  93 VIADIHFQPKYV-FAAIEAgcAAVRVNPGN---------------------IKQFDDRIKEIAQAAKDHGTPIRIGVNAG 150
Cdd:PRK02048   87 LVADVHFNPKVAdVAAQYA--EKVRINPGNyvdpgrtfkkleytdeeyaqeIQKIRDRFVPFLNICKENHTAIRIGVNHG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 151 SLDRRLLQKYGRaTPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQL-----AESCDYPLHLGVTEAGPAF 225
Cdd:PRK02048  165 SLSDRIMSRYGD-TPEGMVESCMEFLRICVEEHFTDVVISIKASNTVVMVRTVRLLvavmeAEGMHYPLHLGVTEAGDGE 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2542594439 226 QGTIKSAVAFGALLSRGIGDTIRVSLSAPPAEEVKV 261
Cdd:PRK02048  244 DGRIKSAVGIGALLADGIGDTIRVSLSEEPEAEIPV 279
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
 19-259 1.48e-58

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 202.68  E-value: 1.48e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  19 RRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATI-----ARKSQIPV 93
Cdd:PLN02925   77 RRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIkntlvQKGYNIPL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  94 IADIHFQPKyvFAAIEAGC-AAVRVNPGNI----KQF-------DDRIKEIA----------QAAKDHGTPIRIGVNAGS 151
Cdd:PLN02925  157 VADIHFAPS--VALRVAECfDKIRVNPGNFadrrAQFekleyteDDYQKELEhieevftplvEKCKKYGRAMRIGTNHGS 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 152 LDRRLLQKYGRaTPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMIEAYRQLAESC-----DYPLHLGVTEAGPAFQ 226
Cdd:PLN02925  235 LSDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLVAEMyvlgwDYPLHLGVTEAGEGED 313

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2542594439 227 GTIKSAVAFGALLSRGIGDTIRVSLSAPPAEEV 259
Cdd:PLN02925  314 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 346
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
 229-361 1.41e-20

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 93.36  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 229 IKSAVAFGALLSRGIGDTIRV----SLSAPPAEEVKVGIqiLQSLGLKERRLEIVSCPSCGRAQVDVYKLA---EEVTAG 301
Cdd:PRK02048  467 LKAAADMGALIFDGLCDGIFLfnqgKLSHVVVDATAFGI--LQAGRLRTSKTEYISCPGCGRTLYDLQSTIariKEATSH 544

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2542594439 302 LDGmevpLRVAVMGCVVNGPGEAREADLG-VASGNGKGQIFVKGE-VIKTVPESKIVETLIE 361
Cdd:PRK02048  545 LKG----LKIGIMGCIVNGPGEMADADYGyVGAGRGKISLYKQKEcVEKNIPEEEAVERLIE 602
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
 229-361 1.89e-13

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 71.71  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 229 IKSAVAFGALLSRGIGDTIRVSLSAPPAEEVK-VGIQILQSLGLKERRLEIVSCPSCGRAQVDVYKLAEEV---TAGLDG 304
Cdd:PLN02925  584 IQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRnTSFGLLQGCRMRNTKTEYVSCPSCGRTLFDLQEVSAEIrekTSHLPG 663

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2542594439 305 MEVplrvAVMGCVVNGPGEAREADLG-VASGNGKGQIFVKGEVIK-TVPESKIVETLIE 361
Cdd:PLN02925  664 VSI----AIMGCIVNGPGEMADADFGyVGGAPGKIDLYVGKEVVKrGIAMEEATDALIQ 718
YcjR COG1082
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];
37-269 7.14e-04

Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 440699 [Multi-domain]  Cd Length: 254  Bit Score: 40.77  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439  37 PVSVQSMTTtRTSDVGATLQQIAELTASGCQIVRVAcPTQDDADALATIARKSQIPVIA------DIHFQPKYVFAAIEA 110
Cdd:COG1082     2 KLGLSTYSL-PDLDLEEALRAAAELGYDGVELAGGD-LDEADLAELRAALADHGLEISSlhapglNLAPDPEVREAALER 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 111 -----------GCAAVRVNPG-----------NIKQFDDRIKEIAQAAKDHGtpIRIGV--NAGSLDRrllqkygraTPE 166
Cdd:COG1082    80 lkraidlaaelGAKVVVVHPGsppppdlppeeAWDRLAERLRELAELAEEAG--VTLALenHEGTFVN---------TPE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 167 ALVEsalweasLFEEHGFRDIKI-------SVKHNDPVVMIEAYRQLAES---CDYPLHLGVteagPAFQGTIKSAVAFG 236
Cdd:COG1082   149 EALR-------LLEAVDSPNVGLlldtghaLLAGEDPVELLRKLGDRIKHvhlKDADGDQHL----PPGEGDIDFAAILR 217

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2542594439 237 ALlsRGIGDTIRVSL-----SAPPAEEVKVGIQILQSL 269
Cdd:COG1082   218 AL--KEAGYDGWLSLevesdPDDPEEAARESLEYLRKL 253
RME-8_N pfam19432
DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in ...
 124-210 8.34e-03

DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in Arabidopsis) is involved in membrane trafficking through early endosomes and in the regulation of endosomal membrane tubulation. It regulates the dynamics of SNX1 (sorting nexin 1) on the endosomal membrane. It coordinates the function of the WASH complex and the retromer SNX dimer through its interaction with FAM21 subunit in WASH complex. This is the N-terminal domain of RME-8, which is required for membrane association and interaction with FAM21 tail domain. It contains critical residues mediating phosphatidylinositol 3-phosphate (PI(3)P) binding, required for its association with endosomes.


Pssm-ID: 466078  Cd Length: 819  Bit Score: 38.36  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2542594439 124 QFDDRIKEIAQAAKDH-GTPIRIGVNAGSLDRRLLQKYGRATPEALVESalweaslFEEhgFRDIKISVKHNDPVVMIEA 202
Cdd:pfam19432 176 NRDELIKKIRENAAEYiGIPIKVAKEPITLDQFKLTRLGKYSSDEHLTS-------LAE--FPVQKISPRHPDPVRRLLC 246


                  ....*...
gi 2542594439 203 yrqLAESC 210
Cdd:pfam19432 247 ---LSETC 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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