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Conserved domains on  [gi|2543350141|ref|WP_299239713|]
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ankyrin repeat domain-containing protein [uncultured Actinomyces sp.]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-134 1.52e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.29  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  18 IASGDVEAVARAVARceiGAYL--RGSAYEPRLMH--FPASEEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPM 93
Cdd:COG0666    95 ARNGDLEIVKLLLEA---GADVnaRDKDGETPLHLaaYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2543350141  94 LIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADP 134
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-134 1.52e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.29  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  18 IASGDVEAVARAVARceiGAYL--RGSAYEPRLMH--FPASEEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPM 93
Cdd:COG0666    95 ARNGDLEIVKLLLEA---GADVnaRDKDGETPLHLaaYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2543350141  94 LIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADP 134
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-176 2.16e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  48 LMHF--PASEEITDFLLARGEDINSRDRYQRTPIHARVQSRC-LDQIPMLIARGGDINARDTSDQTALF----GVVERFP 120
Cdd:PHA03095   54 YLHYssEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvylsGFNINPK 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2543350141 121 VADVsrMIAWGADplvVADSRVYGKATLvesvvawHNFLDTPRA-LAVIRLLLSVGA 176
Cdd:PHA03095  134 VIRL--LLRKGAD---VNALDLYGMTPL-------AVLLKSRNAnVELLRLLIDAGA 178
Ank_5 pfam13857
Ankyrin repeats (many copies);
61-112 1.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2543350141  61 LLARG-EDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTAL 112
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-134 1.52e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.29  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  18 IASGDVEAVARAVARceiGAYL--RGSAYEPRLMH--FPASEEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPM 93
Cdd:COG0666    95 ARNGDLEIVKLLLEA---GADVnaRDKDGETPLHLaaYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2543350141  94 LIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADP 134
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-176 2.16e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  48 LMHF--PASEEITDFLLARGEDINSRDRYQRTPIHARVQSRC-LDQIPMLIARGGDINARDTSDQTALF----GVVERFP 120
Cdd:PHA03095   54 YLHYssEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvylsGFNINPK 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2543350141 121 VADVsrMIAWGADplvVADSRVYGKATLvesvvawHNFLDTPRA-LAVIRLLLSVGA 176
Cdd:PHA03095  134 VIRL--LLRKGAD---VNALDLYGMTPL-------AVLLKSRNAnVELLRLLIDAGA 178
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-139 5.19e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 5.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  55 EEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADP 134
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245


                  ....*
gi 2543350141 135 LVVAD 139
Cdd:COG0666   246 NAKDK 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-189 1.95e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.80  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  48 LMHFPASEEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQ--IPMLIARGGDINARDTSDQTALFGVVE--RFPVAD 123
Cdd:PHA03095   90 YLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGMTPLAVLLKsrNANVEL 169

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141 124 VSRMIAWGADPLVVADSRvygkatlvesVVAWHNFLDTPRALA-VIRLLLSVG---APVGERVPTALRSM 189
Cdd:PHA03095  170 LRLLIDAGADVYAVDDRF----------RSLLHHHLQSFKPRArIVRELIRAGcdpAATDMLGNTPLHSM 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-178 5.08e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 5.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  55 EEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADP 134
Cdd:COG0666    67 LLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2543350141 135 LVVADsrvYGKATLVesVVAWHNFLDtpralaVIRLLLSVGAPV 178
Cdd:COG0666   147 NAQDN---DGNTPLH--LAAANGNLE------IVKLLLEAGADV 179
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-146 8.71e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 8.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  61 LLARGEDINSRDRYQRTPIHARVQSRC-LDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVsrMIAWGADplvVAD 139
Cdd:PHA02876  428 LIDRGANVNSKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNI--LLHYGAE---LRD 502


                  ....*..
gi 2543350141 140 SRVYGKA 146
Cdd:PHA02876  503 SRVLHKS 509
PHA03095 PHA03095
ankyrin-like protein; Provisional
 61-181 1.04e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  61 LLARGEDINSRDRYQRTPIHARVQSRC---LDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVSR-MIAWGADplv 136
Cdd:PHA03095   33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKlLIKAGAD--- 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2543350141 137 VADSRVYGKATLvesvvawHNFLDTPRALA-VIRLLLSVGAPVGER 181
Cdd:PHA03095  110 VNAKDKVGRTPL-------HVYLSGFNINPkVIRLLLRKGADVNAL 148
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 56-181 1.76e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  56 EITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQ-IPMLIARGGDINARDTSDQTALFGVVER-FPVADVSRMIAWGAD 133
Cdd:PHA02876  254 ETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNgYDTENIRTLIMLGAD 333

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2543350141 134 plVVADSRVYgkatlvesVVAWHNFLDTPRALAVIRLLLSVGAPVGER 181
Cdd:PHA02876  334 --VNAADRLY--------ITPLHQASTLDRNKDIVITLLELGANVNAR 371
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-178 7.10e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 7.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  61 LLARGEDINSRDRYQRTPIH-ARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGADplVVAD 139
Cdd:PHA02876  327 LIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD--IEAL 404

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543350141 140 SRVYGKA---------------TLVE---SVVAWHNFLDTPRALA--------VIRLLLSVGAPV 178
Cdd:PHA02876  405 SQKIGTAlhfalcgtnpymsvkTLIDrgaNVNSKNKDLSTPLHYAckknckldVIEMLLDNGADV 469
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-133 5.84e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 5.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543350141  55 EEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVSRMIAWGAD 133
Cdd:COG0666   199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-178 2.23e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.95  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  49 MHFPAS---EEITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVERFPVADVS 125
Cdd:PHA02878  172 LHYATEnkdQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDIL 251

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2543350141 126 RM-IAWGADplVVADSRVYGkatlvesVVAWHNFLDTPRalaVIRLLLSVGAPV 178
Cdd:PHA02878  252 KLlLEHGVD--VNAKSYILG-------LTALHSSIKSER---KLKLLLEYGADI 293
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 57-112 9.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 9.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2543350141  57 ITDFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTAL 112
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVL 215
PHA03095 PHA03095
ankyrin-like protein; Provisional
 59-118 1.07e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543350141  59 DFLLARGEDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTALFGVVER 118
Cdd:PHA03095  241 LPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRN 300
Ank_5 pfam13857
Ankyrin repeats (many copies);
61-112 1.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2543350141  61 LLARG-EDINSRDRYQRTPIHARVQSRCLDQIPMLIARGGDINARDTSDQTAL 112
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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