|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-423 |
3.10e-83 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 260.63 E-value: 3.10e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 43 YKKYFLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFL 122
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 123 LGVLTIFGWITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGA 202
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 203 FILNALSYIAVLFALKKIKIDSVIKTHLPNPIV--AIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFH 280
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 281 VDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANT 360
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543366760 361 TIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFL 423
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
51-424 |
6.99e-57 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 195.74 E-value: 6.99e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 51 LISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFG 130
Cdd:pfam05977 20 LASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 131 WITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSY 210
Cdd:pfam05977 100 LLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSY 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 211 IAVLFALKKIKIDSVIKTHLPNPIV-AIKEGLDYSFKHPIIRTLFL---VIGIVSIFGWSyttVLPVIAKKVFHVDAAGL 286
Cdd:pfam05977 180 FAVIAALWRWKRAAPASPLPRERIFgAVRAGLRFTAMSRELRSVLVrafAFGLSASAVWA---LLPLVARDLLDGDAIFY 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 287 GYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLV 366
Cdd:pfam05977 257 GILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSV 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366760 367 KSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:pfam05977 337 PRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFR 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
47-382 |
7.04e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 151.28 E-value: 7.04e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVL 126
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 127 TifgwiTIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILN 206
Cdd:COG2814 96 P-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 207 ALSYIAVLFALKKikidsVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGL 286
Cdd:COG2814 171 AVLALLALLLLLR-----LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 287 GYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLV 366
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330
....*....|....*.
gi 2543366760 367 KSEFRGRVMSIYVLMF 382
Cdd:COG2814 326 PPEARGRASGLYNSAF 341
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
47-424 |
1.48e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 118.45 E-value: 1.48e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILfatqIASMILAFLLGVL 126
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLL----LLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 127 TIFGwITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFIL- 205
Cdd:cd17325 78 FAFA-TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVc 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 206 NALSYIAVLFALKKIKIDSVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAG 285
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 286 LGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQML 365
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 366 VKSEFRGRVMSIY-VLMFIGLTpFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17325 317 VPPEGRGTAMGLFnTAFSLGMV-LGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
75-424 |
2.80e-24 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 106.16 E-value: 2.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 75 VFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWitIWEICTISFLLGTVNAIDAPA 154
Cdd:PRK08633 46 VILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGW--FWLAFAVTFLLGAQSAIYSPA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 155 RQAFVSELVNKEQLASA---------------IALNSGVFNSARVIGPTVAGIMIAIIGtggaFILNALSYIAVLFALKK 219
Cdd:PRK08633 124 KYGIIPELVGKENLSRAnglleaftivailagTALFSFLFESVNGNTPSEILGRIAPAG----LVLLAVAVLGLIFAYRL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 220 IKIDSVIKTHLP----NPIVAIKEGLDYSFKHpiiRTLFL-VIGIvSIFgWS----YTTVLPVIAKKVFHV-DAAGLGYL 289
Cdd:PRK08633 200 PKVPAAAPEVFDkkkyLFPKLLWRNLKLLRSD---RVLWLaIIGL-SYF-WFisqlAQANFPAYAKEVLGLdNTFQVQYL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 290 YAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSE 369
Cdd:PRK08633 275 LAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEK 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543366760 370 FRGRVMS-------IYVLMFIGLTP-FGNLQIGWVSEYFGTSFALQAGaTIVMVSGLVIFFLR 424
Cdd:PRK08633 355 ELGKVLAannflqnVGMLLFLALTTlFSGLGLSPAGLFYLIALVTLIG-TLYTLLLLPDSLLR 416
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
47-382 |
1.27e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.96 E-value: 1.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQIVAQSWLVLQ-LTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATqiasmILAFLLGV 125
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG-----LLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 126 LTIFGWITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFIL 205
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 206 NALsyIAVLFALKKIKIDSVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIA--KKVFHVDA 283
Cdd:pfam07690 157 LAI--LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPlyQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 284 AGLGYLYAASGLGSLLATITIALYSKKFSP---LYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANT 360
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340
....*....|....*....|..
gi 2543366760 361 TIQMLVKSEFRGRVMSIYVLMF 382
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAG 336
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
40-423 |
1.01e-22 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 99.67 E-value: 1.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 40 SENYKKYFLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFP-KKDILFATQIASmi 118
Cdd:PRK10489 16 HPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDrKKLILLARGTCG-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 119 LAFL-LGVLTIFGWITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAII 197
Cdd:PRK10489 94 LGFIgLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 198 GTGGAFILNALSYIAVLFALKKIKIDSVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGwSYTTVLPVIAKK 277
Cdd:PRK10489 174 GVAWNYGLAAAGTFITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMAS-AVRVLYPALADE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 278 VFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTAsiLLFFSGFGLLSFASQ 357
Cdd:PRK10489 253 VWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILA--VLCLALFGYLSAISS 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2543366760 358 --ANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFL 423
Cdd:PRK10489 331 llQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLV 398
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-424 |
1.14e-20 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 93.06 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQI-VAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGV 125
Cdd:cd17329 5 LIGSFLNRLGFFMVWpFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 126 LTIFgwitiWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGgAFIL 205
Cdd:cd17329 85 AHSP-----WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-LFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 206 NALSYIaVLFALKKIKIDSVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAG 285
Cdd:cd17329 159 AAVLFL-LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 286 LGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQML 365
Cdd:cd17329 238 LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2543366760 366 VKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17329 318 APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
78-427 |
1.10e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.93 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 78 IGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTifgwiTIWEICTISFLLGTVNAIDAPARQA 157
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT-----SFWQLLLLRFLLGLGEAGFFPAALK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 158 FVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALsyIAVLFALkkikidsvikthlpnpivai 237
Cdd:COG2271 122 LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL--PGLLLAL-------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 238 kegldysfkhPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKF--SPLY 315
Cdd:COG2271 180 ----------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 316 FIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGW 395
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329
|
330 340 350
....*....|....*....|....*....|..
gi 2543366760 396 VSEYFGTSFALQAGATIVMVSGLVIFFLRKRI 427
Cdd:COG2271 330 LLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
70-423 |
5.51e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.01 E-value: 5.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 70 QLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWEictisFLLGTVNA 149
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR-----ALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 150 IDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGImIAIIGTGGAFILNALSYIAVLFALKKIKIDSVIKTH 229
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 230 LPNPIVAIKEGLdySFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYS- 308
Cdd:cd17474 182 SSSATKLRDLKK--ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLk 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 309 KKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIY-VLMFIGLTp 387
Cdd:cd17474 260 KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYnFVRFLGQA- 338
|
330 340 350
....*....|....*....|....*....|....*.
gi 2543366760 388 FGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFL 423
Cdd:cd17474 339 VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-424 |
3.37e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 3.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 73 DSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILfatqIASMILAFLLGVLTIFGwITIWEICTISFLLGTVNAIDA 152
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLL----IAGLLLYGIGGVAGLFL-DSLYALLASRALLGIGVAGIM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 153 PARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGiMIAIIGTGGAFILNALSYIAVLFALKKIKIDSVIKTHLPN 232
Cdd:cd17473 107 TLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 233 PIVAIKEgldySFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFS 312
Cdd:cd17473 186 PGAATAA----ALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 313 PLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLM-FIG--LTPFg 389
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAfFLGqfLSPL- 340
|
330 340 350
....*....|....*....|....*....|....*
gi 2543366760 390 nLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17473 341 -VLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-424 |
1.94e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 80.33 E-value: 1.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVL 126
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 127 TifgwiTIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILN 206
Cdd:cd17489 82 T-----SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 207 ALSYIAVLFALKKIKIdsvikthlPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIF-GWSYTTVLPVIAKKVFHVDAAG 285
Cdd:cd17489 157 AVLALLALLLVFLVKD--------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLaSIAYGAISTFLPLYAAERGISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 286 LGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQML 365
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 366 VKSEFRGRVMSIY-VLMFIGLTpFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17489 309 VPPHRRGAANGTFfIFFDLGIG-LGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
46-422 |
2.60e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 2.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 46 YFLGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGV 125
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 126 LTIFGWITIWeictiSFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTG--GAF 203
Cdd:cd06174 81 APSFWLLLLG-----RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 204 ILNALSYIAVLFALKKIKID---SVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFH 280
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDppeSARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 281 VDAAGLGYLYAASGLGSLLATITIA-LYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQAN 359
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGlLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543366760 360 TTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFF 422
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
78-426 |
3.90e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.76 E-value: 3.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 78 IGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTifgwiTIWEICTISFLLGTVNAIDAPARQA 157
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV-----SYWLLLLLGLLLGIGGGGSFAVGIA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 158 FVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSY--IAVLFALKKIKIDSVIKTHLPNPIV 235
Cdd:COG2223 117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLlvVAVLAWLFLRDPPAGAAAAAKASLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 236 AIKEgldySFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLY 315
Cdd:COG2223 197 DQLE----ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 316 FIVGGTLIFSISIFLFSFTdnihTASILLFFSGFGLLSFASQAN-----TTIQMLVKSEFRGRVMSIyVLMFIGLTPF-G 389
Cdd:COG2223 273 VLLIVFALMALGLLLLALA----LGSLWLFLVLFLLLGLALGGGngavfALVPDIFPTKNAGAVYGL-VGAAGGLGGFlG 347
|
330 340 350
....*....|....*....|....*....|....*...
gi 2543366760 390 NLQIGWVSEYFGT-SFALQAGATIVMVSGLVIFFLRKR 426
Cdd:COG2223 348 PLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-421 |
9.11e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.12 E-value: 9.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILfatqIASMILAFLLGVLTIFGWiTIWEICTISFLLGTVNAIDAP 153
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL----LVLLLLFILGNLLAALAP-SFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 154 ARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLFALKKIKIDSVIKTHLPNP 233
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 234 IVAIKEGLdysFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSP 313
Cdd:cd17324 187 LLSSLLLL---LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 314 LYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKsEFRGRVMSIYVL-MFIGLTPFGNLQ 392
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAaYNLGGALGAALG 342
|
330 340
....*....|....*....|....*....
gi 2543366760 393 iGWVSEYFGTSFALQAGATIVMVSGLVIF 421
Cdd:cd17324 343 -GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-421 |
1.41e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 68.72 E-value: 1.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPK-KDILFATQIASMILAFLLGVLTifgwiTIWEICTISFLLGTVNAIDA 152
Cdd:cd17370 32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPLLALAG-----SWQLVLLLRILERLGKGIRT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 153 PARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTG--GAFILNALSYIAVLFALKKIKIDSVIKTHL 230
Cdd:cd17370 107 PPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEYPRPPKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 231 PNPIVAIK-EGLDYSFKhpiirtlfLVIGIVSIFGWSYTTV-LPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYS 308
Cdd:cd17370 187 RKKSKKTSlKKLPKAFW--------LYLLAVALFALGNFSFaFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 309 KKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPF 388
Cdd:cd17370 259 DRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLL 338
|
330 340 350
....*....|....*....|....*....|...
gi 2543366760 389 GNLQIGWVSEYFGTSFALQAGATIVMVSGLVIF 421
Cdd:cd17370 339 ASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
76-424 |
2.01e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 62.23 E-value: 2.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 76 FLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDIlfatqIASMILAFLLGVLTIFGWITIWEICTISFLLGTvNAIDAPAr 155
Cdd:cd17472 32 TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPV-----ILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVV- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 156 QAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNA-LSYIAVLFALKKIKIDSVIKTHLPNPI 234
Cdd:cd17472 105 MALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAiLSLVSLLILLFFVPDPPKIVQISEKEK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 235 VAIKEGLdysfKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHvDAAGLGYLYAASGLGSLLATITIALYSKKFSPL 314
Cdd:cd17472 185 KKLKKLL----KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGG-GKGQLWKVYLPAILIGFILMVPFVIYAEKKGKM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 315 Y--FIVGGTLIFSISIFLFSFTDNIHTASILL--FFSGFGLLSfaSQANTTIQMLVKSEFRGRVMSIYVLM-FIGlTPFG 389
Cdd:cd17472 260 KqvFVSSILLIAVGFLLLLFAATSLWLLIIGLiiFFIGFNLLE--ALLPSLVSKIAPKEYRGTAMGIYNTSqFLG-SFLG 336
|
330 340 350
....*....|....*....|....*....|....*
gi 2543366760 390 NLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17472 337 GALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-351 |
2.66e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 2.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 46 YFLGQLISMIGTWMQivaQSWLVLQLTD----SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKD------ILFATqIA 115
Cdd:COG2211 15 YGLGDLGLNLAFGLL---SAYLLYFYTDvlglSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGA-IP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 116 SMILAFLLGVLTIFGWIT-IWEICTISFLLGTVNAIDAPARQAFVSELV-NKEQLASAIALNSGVFNSARVIGPTVAGIM 193
Cdd:COG2211 91 LALSFVLLFTAPDLSPTGkLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 194 IAIIG-------TGGAFILNALSYIAVLFALKKIKIDSVIKTHLPNpivaIKEGLDYSFKHPIIRTLFLVIGIVSIFGWS 266
Cdd:COG2211 171 VAAFGgdaalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----LKESLKALLKNRPFLLLLLAYLLFFLALAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 267 YTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFF 346
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLA 326
|
....*
gi 2543366760 347 SGFGL 351
Cdd:COG2211 327 ALAGI 331
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
244-423 |
5.36e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.76 E-value: 5.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 244 SFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKvFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLI 323
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 324 FSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTS 403
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|
gi 2543366760 404 FALQAGATIVMVSGLVIFFL 423
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL 184
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
253-426 |
1.02e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 253 LFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFS 332
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 333 FTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATI 412
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....
gi 2543366760 413 VMVSGLVIFFLRKR 426
Cdd:pfam07690 161 SLLAAVLLLLPRPP 174
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
47-422 |
1.05e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 59.97 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGT-----WMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAF 121
Cdd:cd17391 2 WLGNFFTGIGFsliapFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 122 LLGVLTifgwiTIWEICTISFLLGTVNAIdAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGG 201
Cdd:cd17391 82 LMAFVT-----NVWQLLILRLLQGVFSGY-VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 202 AFILNA----LSYIAVLFALKKIKIDSVIKTHLPnpivaIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKK 277
Cdd:cd17391 156 VFFITGgllfLAFLLTLFFVKEDFKPVEKKKMVS-----TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 278 VfHVDAAGL----GYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLS 353
Cdd:cd17391 231 L-MGDASNLafisGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543366760 354 FASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFF 422
Cdd:cd17391 310 LLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
48-327 |
1.66e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 58.67 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 48 LGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLT 127
Cdd:COG0477 21 LGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 128 ifgwiTIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNA 207
Cdd:COG0477 101 -----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 208 LSYIAVLFALKKIKIDSVIKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLG 287
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2543366760 288 YLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSIS 327
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
74-426 |
2.01e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.10 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWeictiSFLLGTVNAIDAP 153
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLA-----LFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 154 ARQAFVSELVNKEQlASAIALNSGVFNSARVIGPTVAGIMIAI---IGTGGAFILNALSYIAVLFALKKIKIDSVIKTHl 230
Cdd:COG0738 116 AANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 231 pNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKK 310
Cdd:COG0738 194 -EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 311 FSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTpFGN 390
Cdd:COG0738 273 FGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGA-IGP 351
|
330 340 350
....*....|....*....|....*....|....*.
gi 2543366760 391 LQIGWVSEYFGTSFALQAGATIVMVSGLVIFFLRKR 426
Cdd:COG0738 352 PLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-381 |
1.99e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.03 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 48 LGQLISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDIlFATQIASMILAFLLGVLT 127
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRV-FLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 128 IFGWITIweicTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNA 207
Cdd:cd17321 82 PSLAFLI----AARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 208 LSYIAVLFAlkkikidsvikthlpnpivaikegldysfkHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLG 287
Cdd:cd17321 158 PIGLVALLL------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 288 YLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFT---DNIHTASILLFFSGFGLLSFASQANTTIQM 364
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALS 287
|
330
....*....|....*..
gi 2543366760 365 LVKSEFRGRVMSIYVLM 381
Cdd:cd17321 288 SVPKEKAGAASGILNTA 304
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
253-423 |
4.98e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 4.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 253 LFLVIGIVSIFGWSYTTVLPVIA---KKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIF 329
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAApplQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 330 LFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAG 409
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170
....*....|....
gi 2543366760 410 ATIVMVSGLVIFFL 423
Cdd:COG2271 171 GLPGLLLALLRFWL 184
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
69-415 |
5.64e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.51 E-value: 5.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 69 LQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWeictiSFLLGTVN 148
Cdd:cd17330 27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA-----RFLDGLTG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 149 AIDAPArQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGG----AFILNALSYIAVLFALKKIKids 224
Cdd:cd17330 102 GNVSVA-QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALpflvAAALALLNLVLVLFFLPPLR--- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 225 vikthlpnpivaikegldysfkhpiirtLFLVIGIVSIFGWS-YTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATIT 303
Cdd:cd17330 178 ----------------------------RLLLVYFLIALAFAgLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 304 IALYS-KKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIY---- 378
Cdd:cd17330 230 LIPRLaKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIqslq 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 2543366760 379 -VLMFIGLTPFGNLQIGWvseYFGTSFALQAGATIVMV 415
Cdd:cd17330 310 sLARIIGPLLAGPLYSFL---GPGVPFLLAAGLLLIAL 344
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
69-424 |
8.54e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.73 E-value: 8.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 69 LQLTDSVFLIGlvMALSTLptllftlFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWeictiSFLLGTVN 148
Cdd:cd17320 36 VQLTLSAYLLG--FALGQL-------LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA-----RFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 149 AIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAF----ILNALSYIAVLFALKKIKIDS 224
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvflaLLGLLLLLLVLLFLPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 225 VIKTHLPNPIVAIKegldYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITI 304
Cdd:cd17320 182 KRKPLLSSLLRAYK----RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 305 ALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFA---SQANTTIQMLVKSEFR-GRVMSIYVL 380
Cdd:cd17320 258 GRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGfglIFPNATSLALEPFPHVaGTASALLGF 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2543366760 381 MFIGLTPFGNLQIGWVseYFGTSFALQAGATIVMVSGLVIFFLR 424
Cdd:cd17320 338 LQFLIGALAGALVGLL--PNGTALPMGLLILVLGLLALLLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-217 |
8.88e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 8.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 51 LISMIGTWMQIVAQSWLVLQLTD----SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFatqIASMILAFLLGVL 126
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEvrglSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV---LAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 127 TIFGWITIWEICTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILN 206
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
170
....*....|.
gi 2543366760 207 ALSYIAVLFAL 217
Cdd:COG2271 344 AALALLAALLA 354
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
66-421 |
1.46e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 66 WLVLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDR-FPKKDILFATQIASMILAFLLGVLTIFgwitiWEICTISFLL 144
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNY-----WVLLLVGVVL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 145 GTVNAIDAPARQAFVSELVNKEQLASAIALNS---GVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLF-ALKKI 220
Cdd:cd17471 97 LSLGAAAFPQLFALAREYADRSSGRDATLFNSvlrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALlVLFLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 221 KIDSVIKTHLPNPIVAIKEGldysfKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYaasGLGSLL- 299
Cdd:cd17471 177 PSVKPPAQKATPASSLVKAP-----VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALe 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 300 --ATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKsEFRGRVMSI 377
Cdd:cd17471 249 ipIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2543366760 378 YVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIF 421
Cdd:cd17471 328 YSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
74-422 |
3.12e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWItiweiCTISFLLGTVNAIDAP 153
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-----LLLVALAGIGSAAFHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 154 ARQAFVSeLVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLFALKKIKidSVIKTHLPNP 233
Cdd:cd17478 104 EGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--PLKKPEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 234 IVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFhVDAAGLGYLYAASGLGSLLATITIALYSKKFSP 313
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 314 LYFIVGGTLIFSISIFLFSFTDNIHTAsILLFFSGFGLLSFASQANTTIQMLVKsEFRGRVMSIYVLMFIGLTPFGNLQI 393
Cdd:cd17478 260 RRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVL 337
|
330 340
....*....|....*....|....*....
gi 2543366760 394 GWVSEYFGTSFALQAgATIVMVSGLVIFF 422
Cdd:cd17478 338 GALADAFGLESVLLI-LALLPLLGALLAF 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
253-425 |
7.07e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 7.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 253 LFLVIGIVSIFGWSYTTVLPVIAKKvFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFS 332
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 333 FTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALqaGATI 412
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLI--AAVL 157
|
170
....*....|...
gi 2543366760 413 VMVSGLVIFFLRK 425
Cdd:cd17477 158 LLLALVPLLLTRR 170
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
153-377 |
7.95e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.07 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 153 PARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLF-------ALKKIKIDSV 225
Cdd:cd17331 105 QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVlvillipSNTKSKREKE 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 226 IKTHLPNPIVAIKEGLDYSFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLAT-ITI 304
Cdd:cd17331 185 AKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQgLLV 264
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2543366760 305 ALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSI 377
Cdd:cd17331 265 GPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGL 337
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
51-219 |
8.41e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.65 E-value: 8.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 51 LISMIGTWMQIVAQSWLVLQLTDSVFLIGLVMALSTLPTLLF-TLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIF 129
Cdd:cd17330 185 LIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSV 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 130 GWITIweictISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALS 209
Cdd:cd17330 265 PLLVL-----AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGL 339
|
170
....*....|
gi 2543366760 210 YIAVLFALKK 219
Cdd:cd17330 340 LLIALFLLSL 349
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
69-423 |
4.69e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 69 LQLTDSVFliGLVMALSTLPTLLFTLFGGVIVDRF-PKKDILFAT---QIASMILAFLLGVLTIFgwitiweicTISFLL 144
Cdd:cd17319 33 LGLSPTQY--GLIASAFFLGYALFQVPGGWLLDRFgARKVLAVSMllwSLFTALTGFATSLTSLY---------VLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 145 GTVNAIDAPARQAFVSELVNKEQLASAialnSGVFNSARVIGPTVAG-IMIAIIGTGG---AFIL-NALSYIAVLFALKK 219
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFPARERGRA----TGLFNSGAPLGAAIGPpLSGWLLLLFGwrwAFIIeGLLGLLLAVLWWFY 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 220 IKidsvikthlpnpivaikegldysfkhpiiRTLFLVIG--IVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGS 297
Cdd:cd17319 178 LR-----------------------------QVWGLALGyfGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 298 LLATITIALYSKKFSPL---YFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRV 374
Cdd:cd17319 229 AIGMILGGRLSDRLLRGarrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2543366760 375 MSIYVLMFIGLTPFGNLQIGWVSEYFGT-SFALQAGATIVMVSGLVIFFL 423
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDATGSyTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-346 |
9.66e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 47 FLGQLISMIGTWMQIvaqSWLVLQLTD---SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKdilFATQIASMILAFLL 123
Cdd:cd17477 2 LLSVALLGLGSGLLL---PLLSLRLERegvSTALIGLVASAYYLGILLGSPLVPRLIRRVGHI---RAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 124 GVLTIFGWITIWeiCTISFLLGTVNAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPtvagIMIAIIGTGGAF 203
Cdd:cd17477 76 LLLALTDSPWVW--FLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP----LLLALVGTAGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 204 ILnALSYIAVLFALkkikidsVIKTHLPNPIVAIKEGLDYSFKH--PIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVfHV 281
Cdd:cd17477 150 PF-LIAAVLLLLAL-------VPLLLTRRAAPEIEEAESISLRRllRIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GL 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2543366760 282 DAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFF 346
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
270-426 |
1.23e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.16 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 270 VLPVIAKkVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGF 349
Cdd:cd17324 21 LLPDIAR-DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2543366760 350 GLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFG--TSFALQAGATIVmVSGLVIFFLRKR 426
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwrAAFLAIAVLALL-AALLLWRLLPSL 177
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
97-423 |
2.46e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 97 GVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWEIctisfLLGTVNAIDAPARQAFVSELVNKEQLASAIALNS 176
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI-----LQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 177 GVFNSARVIGPTVAGIMIAIIGTGGAFilnalsYIAVLFALKKIKIDSVIKTHLpnpivaikegldysFKHPIIRTLFLV 256
Cdd:cd17503 127 LVILLAPAIGPTLGGWLTDNLSWRWIF------YINLPIGILALLLAPLLDLRL--------------FKDRNFTLGLLL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 257 IGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSF--- 333
Cdd:cd17503 187 SFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltp 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 334 TDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIY-VLMFIG-----------LTPFGNLQIGWVSEYFG 401
Cdd:cd17503 267 DTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGgsigtallatlLTNRTQFHHSRLSELLA 346
|
330 340
....*....|....*....|..
gi 2543366760 402 TSFALQAGATIVMVSGLVIFFL 423
Cdd:cd17503 347 QQVQKQALIIAFNDAFLVSAIL 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
249-377 |
7.51e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.84 E-value: 7.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 249 IIRTLFLVIGIVSifgWSYTTVLPVIaKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISI 328
Cdd:COG0738 12 AIYLLFFLWGFAT---ALWGPLIPAL-KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2543366760 329 FLFSFTDNIHTASILLFFSGFGLLSFASQANTTIQMLVKsEFRGRVMSI 377
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNL 135
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
77-350 |
7.99e-05 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 45.34 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 77 LIGLVMALSTLPTLLFTLFGGVIVDRFPKK---DILFATQIASMILAfLLGvltiFGWITIWEICTISFLLGTVNAIDAP 153
Cdd:PRK06814 53 LVTLAGAVFILPFFIFSALAGQLADKYDKAklaKILKFAEIGIAALA-IYG----FHLNSVPLLFAALFLMGIHSALFGP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 154 ARQAFVSELVNKEQLASAIALNSGVFNSARVIGpTVAGiMIAIIGTGGAFILNALSYIAV---LFAL---------KKIK 221
Cdd:PRK06814 128 IKYSILPDHLNKDELLGANALVEAGTFIAILLG-TIIG-GLATISGNFVILVALLMGIAVlgwLASLfipktgnaaPDLK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 222 IDsvikthlPNPIVAIKEGLDYSFKHpiiRTLFLVIGIVSIF---GWSYTTVLPVIAKKVFHVDAAGLGYLYA----ASG 294
Cdd:PRK06814 206 ID-------RNIIRSTITLLKYAKAD---KRIWLAILGISWFwlvGAVVLSQLPLLAKETLGGDENVATLFLAvfsvGVA 275
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2543366760 295 LGSLLATitiALYSKKFSPLYFIVGGTL--IFSISIFLF---SFTDNIHTASILLFFSGFG 350
Cdd:PRK06814 276 VGSFLAS---KLSEGRITLLYVPIGALLmgLFGLDLAFAsssVPAEPAQLKSILVFLSKRH 333
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
254-428 |
1.04e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 254 FLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSF 333
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 334 TDNIHTASILLFFSGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFalQAGATIV 413
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW--RAVFLIA 158
|
170
....*....|....*
gi 2543366760 414 MVSGLVIFFLRKRII 428
Cdd:cd06174 159 AALALLAAILLLLVV 173
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
74-351 |
1.19e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.23 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILfatqiasmILAFLLGVLTIFGWITIWEICTIS---FLLGTVNAI 150
Cdd:cd17333 29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTL--------ILGLLLISLALALIFATPSIYLFVvlmFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 151 DAPARQAFVSELVNKEQlASAIALNSGVFNSARVIGPTVAGIMIAIIGT-----GGAFILNALSYIAVLFALKKIKIDSV 225
Cdd:cd17333 101 LDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATSLLTSELSwswayLIIGLIYLLLAILILLTLFPELPSAR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 226 IKTHLPNPIVAIKEGLdysFKHPIIRTLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIA 305
Cdd:cd17333 180 NPQQSVGAFSASASRL---LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGG 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2543366760 306 LYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGL 351
Cdd:cd17333 257 PISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-217 |
1.47e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 68 VLQLTDSVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATqiasmILAFLLGVLTIFGWITIWEICTISFLLGTV 147
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG-----YLSLALAYLGFALGSSLWLLLLGFILWGLY 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 148 NAIDAPARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLFAL 217
Cdd:cd17370 301 MGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-217 |
6.17e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 6.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIweicTISFLLGTVNAIDAP 153
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL----VLLFLWGGAAGPLYT 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2543366760 154 ARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTGGAFILNALSYIAVLFAL 217
Cdd:cd17477 297 LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
259-427 |
6.35e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 6.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 259 IVSIFGWSYTTVLPVIAKKvFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIH 338
Cdd:cd17478 7 LNDFYQGFLPALLPLLIAK-LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 339 TASILLFFSGFGLLSFASQANTTIQMLVKSEfRGRVMSIYVLM-FIGLTpFGNLQIGWVSEYFGTSFALQAGATIVMVSG 417
Cdd:cd17478 86 LLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGgNLGFA-LGPLIAAALVALFGGLGLLILLIIPGLAVA 163
|
170
....*....|
gi 2543366760 418 LVIFFLRKRI 427
Cdd:cd17478 164 LLLLRLRPLK 173
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
249-350 |
1.71e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 249 IIRTLFLVIGIVsiFGwSYTTVLPVIaKKVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISI 328
Cdd:cd17393 3 AVAAFFFINGIL--MA-SWATRIPAI-KDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLAL 78
|
90 100
....*....|....*....|..
gi 2543366760 329 FLFSFTDNIHTASILLFFSGFG 350
Cdd:cd17393 79 LLLGLAPSVPALALALFLFGAA 100
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
267-423 |
2.44e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 267 YTTVLPVIAKkVFHVDAAGLGYLYAASGLGSLLATITIALYSKKFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFF 346
Cdd:COG0477 33 VNVALPSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2543366760 347 SGFGLLSFASQANTTIQMLVKSEFRGRVMSIYVLMFIGLTPFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIFFL 423
Cdd:COG0477 112 QGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
74-421 |
7.06e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 74 SVFLIGLVMALSTLPTLLFTLFGGVIVDRFPKKDILFATQIASMILAFLLGVLTIFGWITIWEictisFLLGTVNAIDAP 153
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLR-----FLQGIGIGGEYP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 154 ARQAFVSELVNKEQLASAIALNSGVFNSARVIGPTVAGIMIAIIGTG----GAFILNALSYIAVLFALKKIKIdsvikth 229
Cdd:cd17316 109 GASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTLL------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 230 lpnpivaikegldysfkhpiirtLFLVIGIVSIFGWSYTTVLPVIAKKVFHVDAAGLGYLYAASGLGSLLATITIALYSK 309
Cdd:cd17316 182 -----------------------LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2543366760 310 KFSPLYFIVGGTLIFSISIFLFSFTDNIHTASILLFFSGFGLLSFASQAN--TTIQMLVKSEFRGRVMSI-YVLMFIGLT 386
Cdd:cd17316 239 RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLsYNLGRLGGG 318
|
330 340 350
....*....|....*....|....*....|....*
gi 2543366760 387 PFGNLQIGWVSEYFGTSFALQAGATIVMVSGLVIF 421
Cdd:cd17316 319 GAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| |
